217 results on '"Ros, Martine M."'
Search Results
2. Adherence to the World Cancer Research Fund/American Institute for Cancer Research guidelines and risk of death in Europe: results from the European Prospective Investigation into Nutrition and Cancer cohort study
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Vergnaud, Anne-Claire, Romaguera, Dora, Peeters, Petra H, van Gils, Carla H, Chan, Doris SM, Romieu, Isabelle, Freisling, Heinz, Ferrari, Pietro, Clavel-Chapelon, Françoise, Fagherazzi, Guy, Dartois, Laureen, Li, Kuanrong, Tikk, Kaja, Bergmann, Manuela M, Boeing, Heiner, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Dahm, Christina C, Redondo, Maria Luisa, Agudo, Antonio, Sánchez, María-José, Amiano, Pilar, Chirlaque, María-Dolores, Ardanaz, Eva, Khaw, Kay-Tee, Wareham, Nick J, Crowe, Francesca, Trichopoulou, Antonia, Orfanos, Philippos, Trichopoulos, Dimitrios, Masala, Giovanna, Sieri, Sabina, Tumino, Rosario, Vineis, Paolo, Panico, Salvatore, Bueno-de-Mesquita, H Bas, Ros, Martine M, May, Anne, Wirfält, Elisabet, Sonestedt, Emily, Johansson, Ingegerd, Hallmans, Göran, Lund, Eiliv, Weiderpass, Elisabete, Parr, Christine L, Riboli, Elio, and Norat, Teresa
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- 2013
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3. Dietary fiber intake and risk of hormonal receptor–defined breast cancer in the European Prospective Investigation into Cancer and Nutrition study
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Ferrari, Pietro, Rinaldi, Sabina, Jenab, Mazda, Lukanova, Annekatrin, Olsen, Anja, Tjønneland, Anne, Overvad, Kim, Clavel-Chapelon, Françoise, Fagherazzi, Guy, Touillaud, Marina, Kaaks, Rudolf, von Rüsten, Anne, Boeing, Heiner, Trichopoulou, Antonia, Lagiou, Pagona, Benetou, Vassiliki, Grioni, Sara, Panico, Salvatore, Masala, Giovanna, Tumino, Rosario, Polidoro, Silvia, Bakker, Marije F, van Gils, Carla H, Ros, Martine M, Bueno-de-Mesquita, H Bas, Krum-Hansen, Sanda, Engeset, Dagrun, Skeie, Guri, Pilar, Amiano, Sánchez, Maria-José, Buckland, Genevieve, Ardanaz, Eva, Chirlaque, Dolores, Rodriguez, Laudina, Travis, Ruth, Key, Tim, Khaw, Kay-Tee, Wareham, Nicholas J, Sund, Malin, Lenner, Per, Slimani, Nadia, Norat, Teresa, Aune, Dagfinn, Riboli, Elio, and Romieu, Isabelle
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- 2013
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4. Anthropometric characteristics and risk of lymphoid and myeloid leukemia in the European Prospective Investigation into Cancer and Nutrition (EPIC)
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Hosnijeh, Fatemeh Saberi, Romieu, Isabelle, Gallo, Valentina, Riboli, Elio, Tjønneland, Anne, Halkjær, Jytte, Fagherazzi, Guy, Clavel-Chapelon, Françoise, Dossus, Laure, Lukanova, Annie, Kaaks, Rudolf, Trichopoulou, Antonia, Lagiou, Pagona, Katsoulis, Michael, Panico, Salvatore, Tagliabue, Giovanna, Bonet, Catalina, Dorronsoro, Miren, Huerta, José María, Ardanaz, Eva, Sánchez, Maria-José, Johansen, Dorthe, Borgquist, Signe, Peeters, Petra, Bueno-de-Mesquita, H. Bas, Ros, Martine M., Travis, Ruth C., Key, Timothy J., Vineis, Paolo, and Vermeulen, Roel
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- 2013
5. Plasma carotenoids and vitamin C concentrations and risk of urothelial cell carcinoma in the European Prospective Investigation into Cancer and Nutrition
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Ros, Martine M, Bueno-de-Mesquita, H Bas, Kampman, Ellen, Aben, Katja KH, Büchner, Frederike L, Jansen, Eugene HJM, van Gils, Carla H, Egevad, Lars, Overvad, Kim, Tjønneland, Anne, Roswall, Nina, Boutron-Ruault, Marie Christine, Kvaskoff, Marina, Perquier, Florence, Kaaks, Rudolf, Chang-Claude, Jenny, Weikert, Steffen, Boeing, Heiner, Trichopoulou, Antonia, Lagiou, Pagona, Dilis, Vardis, Palli, Domenico, Pala, Valeria, Sacerdote, Carlotta, Tumino, Rosario, Panico, Salvatore, Peeters, Petra HM, Gram, Inger T, Skeie, Guri, Huerta, José María, Barricarte, Aurelio, Quirós, José Ramón, Sánchez, María José, Buckland, Genevieve, Larrañaga, Nerea, Ehrnström, Roy, Wallström, Peter, Ljungberg, Börje, Hallmans, Göran, Key, Timothy J, Allen, Naomi E, Khaw, Kay-Tee, Wareham, Nick, Brennan, Paul, Riboli, Elio, and Kiemeney, Lambertus A
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- 2012
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6. Personal hair dye use and the risk of bladder cancer: a case-control study from The Netherlands
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Ros, Martine M., Gago-Dominguez, Manuela, Aben, Katja K. H., Bueno-de-Mesquita, H. Bas, Kampman, Ellen, Vermeulen, Sita H., and Kiemeney, Lambertus A.
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- 2012
7. Fiber intake and total and cause-specific mortality in the European Prospective Investigation into Cancer and Nutrition cohort
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Chuang, Shu-Chun, Norat, Teresa, Murphy, Neil, Olsen, Anja, Tjønneland, Anne, Overvad, Kim, Boutron-Ruault, Marie Christine, Perquier, Florence, Dartois, Laureen, Kaaks, Rudolf, Teucher, Birgit, Bergmann, Manuela M, Boeing, Heiner, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Grioni, Sara, Sacerdote, Carlotta, Panico, Salvatore, Palli, Domenico, Tumino, Rosario, Peeters, Petra HM, Bueno-de-Mesquita, Bas, Ros, Martine M, Brustad, Magritt, Åsli, Lene Angell, Skeie, Guri, Quirós, J Ramón, González, Carlos A, Sánchez, María-José, Navarro, Carmen, Ardanaz Aicua, Eva, Dorronsoro, Miren, Drake, Isabel, Sonestedt, Emily, Johansson, Ingegerd, Hallmans, Göran, Key, Timothy, Crowe, Francesca, Khaw, Kay-Tee, Wareham, Nicholas, Ferrari, Pietro, Slimani, Nadia, Romieu, Isabelle, Gallo, Valentina, Riboli, Elio, and Vineis, Paolo
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- 2012
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8. Circulating Biomarkers of One-Carbon Metabolism in Relation to Renal Cell Carcinoma Incidence and Survival
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Johansson, Mattias, Fanidi, Anouar, Muller, David C., Bassett, Julie K., Midttun, Øivind, Vollset, Stein Emil, Travis, Ruth C., Palli, Domenico, Mattiello, Amalia, Sieri, Sabina, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Ljungberg, Börje, Hallmans, Göran, Weiderpass, Elisabete, Skeie, Guri, González, Carlos A., Dorronsoro, Miren, Peeters, Petra H., Bueno-de-Mesquita, H. B(as)., Ros, Martine M., Boutron Ruault, Marie-Christine, Fagherazzi, Guy, Clavel, Françoise, Sánchez, María-José, Gurrea, Aurelio Barricarte, Navarro, Carmen, Quiros, J. Ramon, Overvad, Kim, Tjønneland, Anne, Aleksandrova, Krassimira, Vineis, Paolo, Gunter, Marc J., Kaaks, Rudolf, Giles, Graham, Relton, Caroline, Riboli, Elio, Boeing, Heiner, Ueland, Per Magne, Severi, Gianluca, and Brennan, Paul
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- 2014
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9. Alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
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Duell, Eric J, Travier, Noémie, Lujan-Barroso, Leila, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Morois, Sophie, Palli, Domenico, Krogh, Vittorio, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Quirós, J Ramón, Sánchez-Cantalejo, Emilio, Navarro, Carmen, Gurrea, Aurelio Barricarte, Dorronsoro, Miren, Khaw, Kay-Tee, Allen, Naomi E, Key, Timothy J, Bueno-de-Mesquita, H Bas, Ros, Martine M, Numans, Mattijs E, Peeters, Petra HM, Trichopoulou, Antonia, Naska, Androniki, Dilis, Vardis, Teucher, Birgit, Kaaks, Rudolf, Boeing, Heiner, Schütze, Madlen, Regner, Sara, Lindkvist, Björn, Johansson, Ingegerd, Hallmans, Göran, Overvad, Kim, Egeberg, Rikke, Tjønneland, Anne, Lund, Eiliv, Weiderpass, Elisabete, Braaten, Tonje, Romieu, Isabelle, Ferrari, Pietro, Jenab, Mazda, Stenling, Roger, Aune, Dagfinn, Norat, Teresa, Riboli, Elio, and González, Carlos A
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- 2011
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10. Fruit and Vegetable Consumption and Lymphoma Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)
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Rohrmann, Sabine, Becker, Nikolaus, Linseisen, Jakob, Nieters, Alexandra, Rüdiger, Thomas, Raaschou-Nielsen, Ole, Tjønneland, Anne, Johnsen, Hans E., Overvad, Kim, Kaaks, Rudolf, Bergmann, Manuela M., Boeing, Heiner, Benetou, Vasiliki, Psaltopoulou, Theodora, Trichopoulou, Antonia, Masala, Giovanna, Mattiello, Amalia, Krogh, Vittorio, Tumino, Rosario, Van Gils, Carla H., Peeters, Petra H. M., Bueno-De-Mesquita, H. Bas, Ros, Martine M., Lund, Eiliv, Ardanaz, Eva, Chirlaque, María-Dolores, Jakszyn, Paula, Larrañaga, Nerea, Losada, A., Martínez-García, Carmen, Ågren, Åsa, Hallmans, Göran, Berglund, Göran, Manjer, Jonas, Allen, Naomi E., Key, Timothy J., Bingham, Sheila, Khaw, Kay Tee, Slimani, Nadia, Ferrari, Pietro, Boffetta, Paolo, Norat, Teresa, Vineis, Paolo, and Riboli, Elio
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- 2007
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11. Coffee and tea intake and risk of brain tumors in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort study
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Michaud, Dominique S, Gallo, Valentina, Schlehofer, Brigitte, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Dahm, Christina C, Teucher, Birgit, Lukanova, Annekatrin, Boeing, Heiner, Schütze, Madlen, Trichopoulou, Antonia, Lagiou, Pagona, Kyrozis, Andreas, Sacerdote, Carlotta, Krogh, Vittorio, Masala, Giovanna, Tumino, Rosario, Mattiello, Amalia, Bueno-de-Mesquita, H Bas, Ros, Martine M, Peeters, Petra HM, van Gils, Carla H, Skeie, Guri, Engeset, Dagrun, Parr, Christine L, Ardanaz, Eva, Chirlaque, Maria-Dolores, Dorronsoro, Miren, Sánchez, Maria José, Argüelles, Marcial, Jakszyn, Paula, Nilsson, Lena M, Melin, Beatrice S, Manjer, Jonas, Wirfält, Elisabet, Khaw, Kay-Tee, Wareham, Nick, Allen, Naomi E, Key, Timothy J, Romieu, Isabelle, Vineis, Paolo, and Riboli, Elio
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- 2010
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12. Plasma carotenoids, vitamin C, retinol and tocopherols levels and pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition: A nested case–control study: Plasma micronutrients and pancreatic cancer risk
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Jeurnink, Suzanne M., Ros, Martine M., Leenders, Max, van Duijnhoven, Franzel J.B., Siersema, Peter D., Jansen, Eugene H.J.M., van Gils, Carla H., Bakker, Marije F., Overvad, Kim, Roswall, Nina, Tjønneland, Anne, Boutron-Ruault, Marie-Christine, Racine, Antoine, Cadeau, Claire, Grote, Verena, Kaaks, Rudolf, Aleksandrova, Krasimira, Boeing, Heiner, Trichopoulou, Antonia, Benetou, Vasiliki, Valanou, Elisavet, Palli, Domenico, Krogh, Vittorio, Vineis, Paolo, Tumino, Rosario, Mattiello, Amalia, Weiderpass, Elisabete, Skeie, Guri, Castaño, José María Huerta, Duell, Eric J., Barricarte, Aurelio, Molina-Montes, Esther, Argüelles, Marcial, Dorronsoro, Mire, Johansen, Dorthe, Lindkvist, Björn, Sund, Malin, Crowe, Francesca L., Khaw, Kay-Tee, Jenab, Mazda, Fedirko, Veronika, Riboli, E., and Bueno-de-Mesquita, H. B(as)
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- 2015
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13. Fruit, vegetables, and colorectal cancer risk: the European Prospective Investigation into Cancer and Nutrition
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van Duijnhoven, Fränzel JB, Bueno-De-Mesquita, H Bas, Ferrari, Pietro, Jenab, Mazda, Boshuizen, Hendriek C, Ros, Martine M, Casagrande, Corinne, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Thorlacius-Ussing, Ole, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Morois, Sophie, Kaaks, Rudolf, Linseisen, Jakob, Boeing, Heiner, Nöthlings, Ute, Trichopoulou, Antonia, Trichopoulos, Dimitrios, Misirli, Gesthimani, Palli, Domenico, Sieri, Sabina, Panico, Salvatore, Tumino, Rosario, Vineis, Paolo, Peeters, Petra HM, van Gils, Carla H, Ocké, Marga C, Lund, Eiliv, Engeset, Dagrun, Skeie, Guri, Suárez, Laudina Rodríguez, González, Carlos A, Sánchez, María-José, Dorronsoro, Miren, Navarro, Carmen, Barricarte, Aurelio, Berglund, Göran, Manjer, Jonas, Hallmans, Göran, Palmqvist, Richard, Bingham, Sheila A, Khaw, Kay-Tee, Key, Timothy J, Allen, Naomi E, Boffetta, Paolo, Slimani, Nadia, Rinaldi, Sabina, Gallo, Valentina, Norat, Teresa, and Riboli, Elio
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- 2009
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14. Anthropometric characteristics and risk of lymphoid and myeloid leukemia in the European Prospective Investigation into Cancer and Nutrition (EPIC)
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Saberi Hosnijeh, Fatemeh, Romieu, Isabelle, Gallo, Valentina, Riboli, Elio, Tjønneland, Anne, Halkjær, Jytte, Fagherazzi, Guy, Clavel-Chapelon, Françoise, Dossus, Laure, Lukanova, Annie, Kaaks, Rudolf, Trichopoulou, Antonia, Lagiou, Pagona, Katsoulis, Michael, Panico, Salvatore, Tagliabue, Giovanna, Bonet, Catalina, Dorronsoro, Miren, Huerta, José María, Ardanaz, Eva, Sánchez, Maria-José, Johansen, Dorthe, Borgquist, Signe, Peeters, Petra, Bueno-de-Mesquita, H. Bas, Ros, Martine M., Travis, Ruth C., Key, Timothy J., Vineis, Paolo, and Vermeulen, Roel
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- 2013
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15. Serum B vitamin levels and risk of lung cancer
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Johansson, Mattias, Relton, Caroline, Ueland, Per Magne, Vollset, Stein Emil, Midttun, Oivind, Boffetta, Paolo, Jenab, Mazda, Clavel-Chapelon, Francoise, Nygard, Ottar, Slimani, Nadia, Boutron-Ruault, Marie-Christine, Rohrmann, Sabine, Boeing, Heiner, Weikert, Cornelia, Fagherazzi, Guy, Kaaks, Rudolf, Buenode-Mesquita, Bas, Agudo, Antonio, Barricarte, Aurelio, Navarro, Carmen, Ros, Martine M., van Gils,Carla H., Peeters, Petra H.M., Rodriguez, Laudina, Norat, Teresa, Krogh, Vittorio, Masala, Giovanna, Wareham, Nick, Allen, Naomi E., Crowe, Francesca, Gallo, Valentina, Sanchez, Maria-Jose, Larranaga, Nerea, Khaw, Kay-Tee, Panico, Salvatore, Sacerdote, Carlotta, Tumino, Rosario, Trichopoulou, Antonia, Lagiou, Pagona, Hallmans, Goran, Riboli, Elio, Vineis, Paolo, Brennan, Paul, Trichopoulos, Dimitrios, and Rasmuson, Torgny
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Lung cancer -- Risk factors ,Serum -- Health aspects ,Gene expression -- Analysis - Abstract
A study was conducted to evaluate the association, if any between serum B vitamin levels such as 1-carbon metabolism factors and the risk of lung cancer. Results indicated that such levels and methionine were inversely associated with the risk of lung cancer.
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- 2010
16. Fruit and Vegetable Consumption and Mortality: European Prospective Investigation Into Cancer and Nutrition
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Leenders, Max, Sluijs, Ivonne, Ros, Martine M., Boshuizen, Hendriek C., Siersema, Peter D., Ferrari, Pietro, Weikert, Cornelia, Tjønneland, Anne, Olsen, Anja, Boutron-Ruault, Marie-Christine, Clavel-Chapelon, Françoise, Nailler, Laura, Teucher, Birgit, Li, Kuanrong, Boeing, Heiner, Bergmann, Manuela M., Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Palli, Domenico, Pala, Valeria, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Peeters, Petra H. M., van Gils, Carla H., Lund, Eiliv, Engeset, Dagrun, Redondo, Maria Luisa, Agudo, Antonio, Sánchez, Maria José, Navarro, Carmen, Ardanaz, Eva, Sonestedt, Emily, Ericson, Ulrika, Nilsson, Lena Maria, Khaw, Kay-Tee, Wareham, Nicholas J., Key, Timothy J., Crowe, Francesca L., Romieu, Isabelle, Gunter, Marc J., Gallo, Valentina, Overvad, Kim, Riboli, Elio, and Bueno-de-Mesquita, H. Bas
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- 2013
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17. Macronutrient intake and risk of urothelial cell carcinoma in the European prospective investigation into cancer and nutrition
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Allen, Naomi E., Appleby, Paul N., Key, Timothy J., Bueno-de-Mesquita, H. B., Ros, Martine M., Kiemeney, Lambertus A.L.M., Tjnneland, Anne, Roswall, Nina, Overvad, Kim, Weikert, Steffen, Boeing, Heiner, Chang-Claude, Jenny, Teucher, Birgit, Panico, Salvatore, Sacerdote, Carlotta, Tumino, Rosario, Palli, Domenico, Sieri, Sabina, Peeters, Petra, Quirós, Jose Ramón, Jakszyn, Paula, Molina-Montes, Esther, Chirlaque, María-Dolores, Ardanaz, Eva, Dorronsoro, Miren, Khaw, Kay-Tee, Wareham, Nick, Ljungberg, Börje, Hallmans, Göran, Ehrnström, Roy, Ericson, Ulrika, Gram, Inger Torhild, Parr, Christine L., Trichopoulou, Antonia, Karapetyan, Tina, Dilis, Vardis, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Fagherrazzi, Guy, Romieu, Isabelle, Gunter, Marc J., and Riboli, Elio
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- 2013
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18. Variety in vegetable and fruit consumption and risk of bladder cancer in the European Prospective Investigation into Cancer and Nutrition
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Büchner, Frederike L., Bueno-de-Mesquita, Bas H., Ros, Martine M., Kampman, Ellen, Egevad, Lars, Overvad, Kim, Tjønneland, Anne, Roswall, Nina, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Touillaud, Marina, Kaaks, Rudolf, Chang-Claude, Jenny, Boeing, Heiner, Weikert, Steffen, Trichopoulou, Antonia, Naska, Ada, Benetou, Vicky, Palli, Domenico, Sieri, Sabina, Vineis, Paolo, Tumino, Rosario, Panico, Salvatore, van Duijnhoven, Fränzel J.B., Peeters, Petra H.M., van Gils, Carla H., Lund, Eiliv, Gram, Inger T., Sánchez, Maria-José, Jakszyn, Paula, Larrañaga, Nerea, Ardanaz, Eva, Navarro, Carmen, Rodríguez, Laudina, Manjer, Jonas, Ehrnström, Roy, Hallmans, Göran, Ljungberg, Börje, Key, Tim J., Allen, Naomi E., Khaw, Kay-Tee, Wareham, Nicholas, Slimani, Nadia, Jenab, Mazda, Boffetta, Paolo, Kiemeney, Lambertus A.L.M, and Riboli, Elio
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- 2011
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19. Fluid intake and the risk of urothelial cell carcinomas in the European Prospective Investigation into Cancer and Nutrition (EPIC)
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Ros, Martine M., Bas Bueno-de-Mesquita, H. B., Büchner, Frederike L., Aben, Katja K.H., Kampman, Ellen, Egevad, Lars, Overvad, Kim, Tjnneland, Anne, Roswall, Nina, Clavel-Chapelon, Francoise, Kaaks, Rudolf, Chang-Claude, Jenny, Boeing, Heiner, Weikert, Steffen, Trichopoulou, Antonia, Orfanos, Philippos, Stasinopulou, Georgia, Saieva, Calogero, Krogh, Vittorio, Vineis, Paolo, Tumino, Rosario, Mattiello, Amalia, Peeters, Petra H.M., van Duijnhoven, Fränzel J.B., Lund, Eiliv, Gram, Inger T, Chirlaque, Maria D, Barricarte, Aurelio, Rodríguez, Laudina, Molina, Esther, Gonzalez, Carlos, Dorronsoro, Miren, Manjer, Jonas, Ehrnström, Roy, Ljungberg, Börje, Allen, Naomi E., Roddam, Andrew W., Khaw, Kay-Tee, Wareham, Nick, Boffetta, Paolo, Slimani, Nadia, Michaud, Dominique S., Kiemeney, Lambertus A.L.M., and Riboli, Elio
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- 2011
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20. Association between pre-diagnostic circulating vitamin D concentration and risk of colorectal cancer in European populations: a nested case-control study
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Jenab, Mazda, Bueno-de-Mesquita, Bas H, Ferrari, Pietro, van Duijnhoven, Franzel J B, Norat, Teresa, Pischon, Tobias, Jansen, Eugène H J M, Slimani, Nadia, Byrnes, Graham, Rinaldi, Sabina, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Boutron-Ruault, Marie-Christine, Clavel-Chapelon, Françoise, Morois, Sophie, Kaaks, Rudolf, Linseisen, Jakob, Boeing, Heiner, Bergmann, Manuela M, Trichopoulou, Antonia, Misirli, Gesthimani, Trichopoulos, Dimitrios, Berrino, Franco, Vineis, Paolo, Panico, Salvatore, Palli, Domenico, Tumino, Rosario, Ros, Martine M, van Gils, Carla H, Peeters, Petra H, Brustad, Magritt, Lund, Eiliv, Tormo, María-José, Ardanaz, Eva, Rodríguez, Laudina, Sánchez, Maria-José, Dorronsoro, Miren, Gonzalez, Carlos A, Hallmans, Göran, Palmqvist, Richard, Roddam, Andrew, Key, Timothy J, Khaw, Kay-Tee, Autier, Philippe, Hainaut, Pierre, and Riboli, Elio
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- 2010
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21. Consumption of vegetables and fruit and the risk of bladder cancer in the European Prospective Investigation into Cancer and Nutrition
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Büchner, Frederike L., Bueno-de-Mesquita, Bas H., Ros, Martine M., Kampman, Ellen, Egevad, Lars, Overvad, Kim, Raaschou-Nielsen, Ole, Tjnneland, Anne, Roswall, Nina, Clavel-Chapelon, Francoise, Boutron-Ruault, Marie-Christine, Touillaud, Marina, Chang-Claude, Jenny, Kaaks, Rudolf, Boeing, Heiner, Weikert, Steffen, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Palli, Domenico, Sieri, Sabina, Vineis, Paolo, Tumino, Rosario, Panico, Salvatore, Vrieling, Alina, Peeters, Petra H.M., van Gils, Carla H., Lund, Eiliv, Gram, Inger T., Engeset, Dagrun, Martinez, Carmen, Gonzalez, Carlos A., Larrañaga, Nerea, Ardanaz, Eva, Navarro, Carmen, Rodríguez, Laudina, Manjer, Jonas, Ehrnström, Roy A., Hallmans, Goran, Ljungberg, Borje, Allen, Naomi E., Roddam, Andrew W., Bingham, Sheila, Khaw, Kay-Tee, Slimani, Nadia, Boffetta, Paolo, Jenab, Mazda, Mouw, Traci, Michaud, Dominique S., Kiemeney, Lambertus A.L.M., and Riboli, Elio
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- 2009
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22. Epidemiology and genetic susceptibility to bladder cancer
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Wu, Xifeng, Ros, Martine M., Gu, Jian, and Kiemeney, Lambertus
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- 2008
23. One-carbon metabolism biomarkers and risk of urothelial cell carcinoma in the European prospective investigation into cancer and nutrition
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Vrieling, Alina Bueno-De-Mesquita, H. Bas Ros, Martine M. and Kampman, Ellen Aben, Katja K. Buchner, Frederike L. Jansen, Eugene H. Roswall, Nina Tjonneland, Anne Boutron-Ruault, Marie-Christine Cadeau, Claire Chang-Claude, Jenny Kaaks, Rudolf Weikert, Steffen Boeing, Heiner Trichopoulou, Antonia and Lagiou, Pagona Trichopoulos, Dimitrios Sieri, Sabina and Palli, Domenico Panico, Salvatore Peeters, Petra H. and Weiderpass, Elisabete Skeie, Guri Jakszyn, Paula Chirlaque, Maria-Dolores Ardanaz, Eva Sanchez, Maria-Jose Ehrnstrom, Roy Malm, Johan Ljungberg, Borje Khaw, Kay-Tee Wareham, Nick J. Brennan, Paul Johansson, Mattias Riboli, Elio and Kiemeney, Lambertus A.
- Abstract
Published associations between dietary folate and bladder cancer risk are inconsistent. Biomarkers may provide more accurate measures of nutrient status. This nested case-control analysis within the European Prospective Investigation into Cancer and Nutrition (EPIC) investigated associations between pre-diagnostic serum folate, homocysteine, vitamins B6 and B12 and the risk of urothelial cell carcinomas of the bladder (UCC). A total of 824 patients with newly diagnosed UCC were matched with 824 cohort members. Serum folate, homocysteine, and vitamins B6 and B12 were measured. Odds ratios (OR) and 95% confidence intervals (CI) for total, aggressive, and non-aggressive UCC were estimated using conditional logistic regression with adjustment for smoking status, smoking duration and intensity, and other potential confounders. Additionally, statistical interaction with smoking status was assessed. A halving in serum folate concentrations was moderately associated with risk of UCC (OR: 1.18; 95% CI: 0.98-1.43), in particular aggressive UCC (OR: 1.34; 95% CI: 1.02-1.75; p-heterogeneity = 0.19). Compared to never smokers in the highest quartile of folate concentrations, this association seemed only apparent among current smokers in the lowest quartile of folate concentrations (OR: 6.26; 95% CI: 3.62-10.81, p-interaction = 0.07). Dietary folate was not associated with aggressive UCC (OR: 1.26; 95% CI: 0.81-1.95; p-heterogeneity = 0.14). No association was observed between serum homocysteine, vitamins B6 and B12 and risk of UCC. This study suggests that lower serum folate concentrations are associated with increased UCC risk, in particular aggressive UCC. Residual confounding by smoking cannot be ruled out and these findings require confirmation in future studies with multiple measurements.
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- 2019
24. One-carbon metabolism biomarkers and risk of urothelial cell carcinoma in the European prospective investigation into cancer and nutrition
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Vrieling, Alina, Bueno-De-Mesquita, H. Bas, Ros, Martine M., Kampman, Ellen, Aben, Katja K., Buchner, Frederike L., Jansen, Eugene H., Roswall, Nina, Tjonneland, Anne, Boutron-Ruault, Marie-Christine, Cadeau, Claire, Chang-Claude, Jenny, Kaaks, Rudolf, Weikert, Steffen, Boeing, Heiner, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Sieri, Sabina, Palli, Domenico, Panico, Salvatore, Peeters, Petra H., Weiderpass, Elisabete, Skeie, Guri, Jakszyn, Paula, Chirlaque, Maria-Dolores, Ardanaz, Eva, Sanchez, Maria-Jose, Ehrnstrom, Roy, Malm, Johan, Ljungberg, Börje, Khaw, Kay-Tee, Wareham, Nick J., Brennan, Paul, Johansson, Mattias, Riboli, Elio, Kiemeney, Lambertus A., Vrieling, Alina, Bueno-De-Mesquita, H. Bas, Ros, Martine M., Kampman, Ellen, Aben, Katja K., Buchner, Frederike L., Jansen, Eugene H., Roswall, Nina, Tjonneland, Anne, Boutron-Ruault, Marie-Christine, Cadeau, Claire, Chang-Claude, Jenny, Kaaks, Rudolf, Weikert, Steffen, Boeing, Heiner, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Sieri, Sabina, Palli, Domenico, Panico, Salvatore, Peeters, Petra H., Weiderpass, Elisabete, Skeie, Guri, Jakszyn, Paula, Chirlaque, Maria-Dolores, Ardanaz, Eva, Sanchez, Maria-Jose, Ehrnstrom, Roy, Malm, Johan, Ljungberg, Börje, Khaw, Kay-Tee, Wareham, Nick J., Brennan, Paul, Johansson, Mattias, Riboli, Elio, and Kiemeney, Lambertus A.
- Abstract
Published associations between dietary folate and bladder cancer risk are inconsistent. Biomarkers may provide more accurate measures of nutrient status. This nested case-control analysis within the European Prospective Investigation into Cancer and Nutrition (EPIC) investigated associations between pre-diagnostic serum folate, homocysteine, vitamins B6 and B12 and the risk of urothelial cell carcinomas of the bladder (UCC). A total of 824 patients with newly diagnosed UCC were matched with 824 cohort members. Serum folate, homocysteine, and vitamins B6 and B12 were measured. Odds ratios (OR) and 95% confidence intervals (CI) for total, aggressive, and non-aggressive UCC were estimated using conditional logistic regression with adjustment for smoking status, smoking duration and intensity, and other potential confounders. Additionally, statistical interaction with smoking status was assessed. A halving in serum folate concentrations was moderately associated with risk of UCC (OR: 1.18; 95% CI: 0.98-1.43), in particular aggressive UCC (OR: 1.34; 95% CI: 1.02-1.75; p-heterogeneity = 0.19). Compared to never smokers in the highest quartile of folate concentrations, this association seemed only apparent among current smokers in the lowest quartile of folate concentrations (OR: 6.26; 95% CI: 3.62-10.81, p-interaction = 0.07). Dietary folate was not associated with aggressive UCC (OR: 1.26; 95% CI: 0.81-1.95; p-heterogeneity = 0.14). No association was observed between serum homocysteine, vitamins B6 and B12 and risk of UCC. This study suggests that lower serum folate concentrations are associated with increased UCC risk, in particular aggressive UCC. Residual confounding by smoking cannot be ruled out and these findings require confirmation in future studies with multiple measurements.
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- 2019
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25. One-carbon metabolism biomarkers and risk of urothelial cell carcinoma in the European prospective investigation into cancer and nutrition
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MS MDL 1, Epi Kanker Team 1, Cancer, JC onderzoeksprogramma Kanker, Vrieling, Alina, Bueno-De-Mesquita, H. Bas, Ros, Martine M., Kampman, Ellen, Aben, Katja K., Büchner, Frederike L., Jansen, Eugène H., Roswall, Nina, Tjønneland, Anne, Boutron-Ruault, Marie Christine, Cadeau, Claire, Chang-Claude, Jenny, Kaaks, Rudolf, Weikert, Steffen, Boeing, Heiner, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Sieri, Sabina, Palli, Domenico, Panico, Salvatore, Peeters, Petra H., Weiderpass, Elisabete, Skeie, Guri, Jakszyn, Paula, Chirlaque, María Dolores, Ardanaz, Eva, Sánchez, María José, Ehrnström, Roy, Malm, Johan, Ljungberg, Börje, Khaw, Kay Tee, Wareham, Nick J., Brennan, Paul, Johansson, Mattias, Riboli, Elio, Kiemeney, Lambertus A., MS MDL 1, Epi Kanker Team 1, Cancer, JC onderzoeksprogramma Kanker, Vrieling, Alina, Bueno-De-Mesquita, H. Bas, Ros, Martine M., Kampman, Ellen, Aben, Katja K., Büchner, Frederike L., Jansen, Eugène H., Roswall, Nina, Tjønneland, Anne, Boutron-Ruault, Marie Christine, Cadeau, Claire, Chang-Claude, Jenny, Kaaks, Rudolf, Weikert, Steffen, Boeing, Heiner, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Sieri, Sabina, Palli, Domenico, Panico, Salvatore, Peeters, Petra H., Weiderpass, Elisabete, Skeie, Guri, Jakszyn, Paula, Chirlaque, María Dolores, Ardanaz, Eva, Sánchez, María José, Ehrnström, Roy, Malm, Johan, Ljungberg, Börje, Khaw, Kay Tee, Wareham, Nick J., Brennan, Paul, Johansson, Mattias, Riboli, Elio, and Kiemeney, Lambertus A.
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- 2019
26. Plasma carotenoids, vitamin C, tocopherols, and retinol and the risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition cohort
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Bakker, Marije F. Peeters, Petra H. M. Klaasen, Veronique M. and Bueno-de-Mesquita, H. Bas Jansen, Eugene H. J. M. Ros, Martine M. Travier, Noemie Olsen, Anja Tjonneland, Anne Overvad, Kim Rinaldi, Sabina Romieu, Isabelle Brennan, Paul and Boutron-Ruault, Marie-Christine Perquier, Florence Cadeau, Claire Boeing, Heiner Aleksandrova, Krasimira Kaaks, Rudolf and Kuehn, Tilman Trichopoulou, Antonia Lagiou, Pagona and Trichopoulos, Dimitrios Vineis, Paolo Krogh, Vittorio and Panico, Salvatore Masala, Giovanna Tumino, Rosario and Weiderpass, Elisabete Skeie, Guri Lund, Eiliv Ramon Quiros, J. Ardanaz, Eva Navarro, Carmen Amiano, Pilar Sanchez, Maria-Jose Buckland, Genevieve Ericson, Ulrika Sonestedt, Emily Johansson, Matthias Sund, Malin Travis, Ruth C. and Key, Timothy J. Khaw, Kay-Tee Wareham, Nick Riboli, Elio and van Gils, Carla H.
- Abstract
Background: Carotenoids and vitamin C are thought to be associated with reduced cancer risk because of their antioxidative capacity. Objective: This study evaluated the associations of plasma carotenoid, retinol, tocopherol, and vitamin C concentrations and risk of breast cancer. Design: In a nested case-control study within the European Prospective Investigation into Cancer and Nutrition cohort, 1502 female incident breast cancer cases were included, with an oversampling of premenopausal (n = 582) and estrogen receptor-negative (ER-) cases (n = 462). Controls (n = 1502) were individually matched to cases by using incidence density sampling. Prediagnostic samples were analyzed for alpha-carotene, beta-carotene, lycopene, lutein, zeaxanthin, beta-cryptoxanthin, retinol, alpha-tocopherol, gamma-tocopherol, and 454 vitamin C. Breast cancer risk was computed according to hormone receptor status and age at diagnosis (proxy for menopausal status) by using conditional logistic regression and was further stratified by smoking status, alcohol consumption, and body mass index (BMI). All statistical tests were 2-sided. Results: In quintile 5 compared with quintile 1, alpha-carotene (OR: 0.61; 95% CI: 0.39, 0.98) and beta-carotene (OR: 0.41; 95% CI: 0.26, 0.65) were inversely associated with risk of ER- breast tumors. The other analytes were not statistically associated with ER- breast cancer. For estrogen receptor-positive (ER+) tumors, no statistically significant associations were found. The test for heterogeneity between ER- and ER+ tumors was statistically significant only for beta-carotene (P-heterogeneity = 0.03). A higher risk of breast cancer was found for retinol in relation to ER-/progesterone receptor-negative tumors (OR: 2.37; 95% CI: 1.20, 4.67; P-heterogeneity with ER+/progesterone receptor positive = 0.06). We observed no statistically significant interaction between smoking, alcohol, or BMI and all investigated plasma analytes (based on tertile distribution). Conclusion: Our results indicate that higher concentrations of plasma beta-carotene and alpha-carotene are associated with lower breast cancer risk of ER tumors.
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- 2016
27. Plasma carotenoids, vitamin C, retinol and tocopherols levels and pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition: A nested case-control study Plasma micronutrients and pancreatic cancer risk
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Jeurnink, Suzanne M. Ros, Martine M. Leenders, Max van Duijnhoven, Franzel J. B. Siersema, Peter D. Jansen, Eugene H. J. M. van Gils, Carla H. Bakker, Marije F. Overvad, Kim and Roswall, Nina Tjonneland, Anne Boutron-Ruault, Marie-Christine and Racine, Antoine Cadeau, Claire Grote, Verena Kaaks, Rudolf Aleksandrova, Krasimira Boeing, Heiner Trichopoulou, Antonia Benetou, Vasiliki Valanou, Elisavet Palli, Domenico and Krogh, Vittorio Vineis, Paolo Tumino, Rosario Mattiello, Amalia Weiderpass, Elisabete Skeie, Guri Huerta Castano, Jose Maria Duell, Eric J. Barricarte, Aurelio Molina-Montes, Esther Argueelles, Marcial Dorronsoro, Mire Johansen, Dorthe and Lindkvist, Bjorn Sund, Malin Crowe, Francesca L. Khaw, Kay-Tee Jenab, Mazda Fedirko, Veronika Riboli, E. and Bueno-de-Mesquita, H. B(as)
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food and beverages - Abstract
Evidence of a protective effect of several antioxidants and other nutrients on pancreatic cancer risk is inconsistent. The aim of this study was to investigate the association for prediagnostic plasma levels of carotenoids, vitamin C, retinol and tocopherols with risk of pancreatic cancer in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC). 446 incident exocrine pancreatic cancer cases were matched to 446 controls by age at blood collection, study center, sex, date and time of blood collection, fasting status and hormone use. Plasma carotenoids (- and -carotene, lycopene, -cryptoxanthin, canthaxanthin, zeaxanthin and lutein), - and -tocopherol and retinol were measured by reverse phase high-performance liquid chromatography and plasma vitamin C by a colorimetric assay. Incidence rate ratios (IRRs) with 95% confidence intervals (95%CIs) for pancreatic cancer risk were estimated using a conditional logistic regression analysis, adjusted for smoking status, smoking duration and intensity, waist circumference, cotinine levels and diabetes status. Inverse associations with pancreatic cancer risk were found for plasma -carotene (IRR highest vs. lowest quartile 0.52, 95%CI 0.31-0.88, p for trend=0.02), zeaxanthin (IRR highest vs. lowest quartile 0.53, 95%CI 0.30-0.94, p for trend=0.06) and -tocopherol (IRR highest vs. lowest quartile 0.62, 95%CI 0.39-0.99, p for trend=0.08. For - and -carotene, lutein, sum of carotenoids and -tocopherol, heterogeneity between geographical regions was observed. In conclusion, our results show that higher plasma concentrations of -carotene, zeaxanthin and -tocopherol may be inversely associated with risk of pancreatic cancer, but further studies are warranted. What’s new? Fruits and vegetables may play a role in the prevention of pancreatic cancer, but associations between the antioxidants those foods contain and disease risk remain unclear. In this study, pancreatic cancer risk was inversely associated with increased prediagnostic plasma concentrations of the antioxidants -carotene, zeaxanthin, and -tocopherol. Geographic variations were also detected. In Northern European countries, inverse associations with risk were found for blood levels of several carotenoids, whereas the association was strongest for -tocopherol in Southern European countries. The role of carotenoids and vitamins should be considered in subsequent investigations of the etiology of pancreatic cancer.
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- 2015
28. Plasma carotenoids, vitamin C, tocopherols, and retinol and the risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition cohort
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Bakker, Marije F., Peeters, Petra H. M., Klaasen, Veronique M., Bueno-de-Mesquita, H. Bas, Jansen, Eugene H. J. M., Ros, Martine M., Travier, Noemie, Olsen, Anja, Tjønneland, Anne, Overvad, Kim, Rinaldi, Sabina, Romieu, Isabelle, Brennan, Paul, Boutron-Ruault, Marie-Christine, Perquier, Florence, Cadeau, Claire, Boeing, Heiner, Aleksandrova, Krasimira, Kaaks, Rudolf, Kühn, Tilman, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Vineis, Paolo, Krogh, Vittorio, Panico, Salvatore, Masala, Giovanna, Tumino, Rosario, Weiderpass, Elisabete, Skeie, Guri, Lund, Eiliv, Ramon Quirós, J., Ardanaz, Eva, Navarro, Carmen, Amiano, Pilar, Sánchez, María-José, Buckland, Genevieve, Ericson, Ulrika, Sonestedt, Emily, Johansson, Matthias, Sund, Malin, Travis, Ruth C., Key, Timothy J., Khaw, Kay-Tee, Wareham, Nick, Riboli, Elio, van Gils, Carla H., Bakker, Marije F., Peeters, Petra H. M., Klaasen, Veronique M., Bueno-de-Mesquita, H. Bas, Jansen, Eugene H. J. M., Ros, Martine M., Travier, Noemie, Olsen, Anja, Tjønneland, Anne, Overvad, Kim, Rinaldi, Sabina, Romieu, Isabelle, Brennan, Paul, Boutron-Ruault, Marie-Christine, Perquier, Florence, Cadeau, Claire, Boeing, Heiner, Aleksandrova, Krasimira, Kaaks, Rudolf, Kühn, Tilman, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Vineis, Paolo, Krogh, Vittorio, Panico, Salvatore, Masala, Giovanna, Tumino, Rosario, Weiderpass, Elisabete, Skeie, Guri, Lund, Eiliv, Ramon Quirós, J., Ardanaz, Eva, Navarro, Carmen, Amiano, Pilar, Sánchez, María-José, Buckland, Genevieve, Ericson, Ulrika, Sonestedt, Emily, Johansson, Matthias, Sund, Malin, Travis, Ruth C., Key, Timothy J., Khaw, Kay-Tee, Wareham, Nick, Riboli, Elio, and van Gils, Carla H.
- Abstract
Background: Carotenoids and vitamin C are thought to be associated with reduced cancer risk because of their antioxidative capacity. Objective: This study evaluated the associations of plasma carotenoid, retinol, tocopherol, and vitamin C concentrations and risk of breast cancer. Design: In a nested case-control study within the European Prospective Investigation into Cancer and Nutrition cohort, 1502 female incident breast cancer cases were included, with an oversampling of premenopausal (n = 582) and estrogen receptor-negative (ER-) cases (n = 462). Controls (n = 1502) were individually matched to cases by using incidence density sampling. Prediagnostic samples were analyzed for alpha-carotene, beta-carotene, lycopene, lutein, zeaxanthin, beta-cryptoxanthin, retinol, alpha-tocopherol, gamma-tocopherol, and 454 vitamin C. Breast cancer risk was computed according to hormone receptor status and age at diagnosis (proxy for menopausal status) by using conditional logistic regression and was further stratified by smoking status, alcohol consumption, and body mass index (BMI). All statistical tests were 2-sided. Results: In quintile 5 compared with quintile 1, alpha-carotene (OR: 0.61; 95% CI: 0.39, 0.98) and beta-carotene (OR: 0.41; 95% CI: 0.26, 0.65) were inversely associated with risk of ER- breast tumors. The other analytes were not statistically associated with ER- breast cancer. For estrogen receptor-positive (ER+) tumors, no statistically significant associations were found. The test for heterogeneity between ER- and ER+ tumors was statistically significant only for beta-carotene (P-heterogeneity = 0.03). A higher risk of breast cancer was found for retinol in relation to ER-/progesterone receptor-negative tumors (OR: 2.37; 95% CI: 1.20, 4.67; P-heterogeneity with ER+/progesterone receptor positive = 0.06). We observed no statistically significant interaction between smoking, alcohol, or BMI and all investigated plasma analytes (based on tertile distribution). C
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- 2016
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29. Plasma carotenoids, Vitamin C, tocopherols, and retinol and the risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition cohort
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Epi Kanker Team A, Cancer, JC onderzoeksprogramma Kanker, Epi Kanker Team 1, Infection & Immunity, Bakker, Marije F., Peeters, Petra H M, Klaasen, Veronique M., Bueno-De-Mesquita, H. Bas, Jansen, Eugene H J M, Ros, Martine M., Travier, Noémie, Olsen, Anja, Tjønneland, Anne, Overvad, Kim, Rinaldi, Sabina, Romieu, Isabelle, Brennan, Paul, Boutron-Ruault, Marie Christine, Perquier, Florence, Cadeau, Claire, Boeing, Heiner, Aleksandrova, Krasimira, Kaaks, Rudolf, Kühn, Tilman, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Vineis, Paolo, Krogh, Vittorio, Panico, Salvatore, Masala, Giovanna, Tumino, Rosario, Weiderpass, Elisabete, Skeie, Guri, Lund, Eiliv, Quirós, J. Ramón, Ardanaz, Eva, Navarro, Carmen, Amiano, Pilar, Sánchez, María José, Buckland, Genevieve, Ericson, Ulrika, Sonestedt, Emily, Johansson, Matthias, Sund, Malin, Travis, Ruth C., Key, Timothy J., Khaw, Kay Tee, Wareham, Nick, Riboli, Elio, Van Gils, Carla H., Epi Kanker Team A, Cancer, JC onderzoeksprogramma Kanker, Epi Kanker Team 1, Infection & Immunity, Bakker, Marije F., Peeters, Petra H M, Klaasen, Veronique M., Bueno-De-Mesquita, H. Bas, Jansen, Eugene H J M, Ros, Martine M., Travier, Noémie, Olsen, Anja, Tjønneland, Anne, Overvad, Kim, Rinaldi, Sabina, Romieu, Isabelle, Brennan, Paul, Boutron-Ruault, Marie Christine, Perquier, Florence, Cadeau, Claire, Boeing, Heiner, Aleksandrova, Krasimira, Kaaks, Rudolf, Kühn, Tilman, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Vineis, Paolo, Krogh, Vittorio, Panico, Salvatore, Masala, Giovanna, Tumino, Rosario, Weiderpass, Elisabete, Skeie, Guri, Lund, Eiliv, Quirós, J. Ramón, Ardanaz, Eva, Navarro, Carmen, Amiano, Pilar, Sánchez, María José, Buckland, Genevieve, Ericson, Ulrika, Sonestedt, Emily, Johansson, Matthias, Sund, Malin, Travis, Ruth C., Key, Timothy J., Khaw, Kay Tee, Wareham, Nick, Riboli, Elio, and Van Gils, Carla H.
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- 2016
30. Circulating Biomarkers of One-Carbon Metabolism in Relation to Renal Cell Carcinoma Incidence and Survival
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Johansson, Mattias Fanidi, Anouar Muller, David C. Bassett, Julie K. Midttun, Oivind Vollset, Stein Emil Travis, Ruth C. and Palli, Domenico Mattiello, Amalia Sieri, Sabina and Trichopoulou, Antonia Lagiou, Pagona Trichopoulos, Dimitrios and Ljungberg, Borje Hallmans, Goran Weiderpass, Elisabete and Skeie, Guri Gonzalez, Carlos A. Dorronsoro, Miren Peeters, Petra H. Bueno-de-Mesquita, H. B(as). Ros, Martine M. and Ruault, Marie-Christine Boutron Fagherazzi, Guy Clavel, Francoise Sanchez, Maria-Jose Barricarte Gurrea, Aurelio and Navarro, Carmen Ramon Quiros, J. Overvad, Kim Tjonneland, Anne Aleksandrova, Krassimira Vineis, Paolo Gunter, Marc J. and Kaaks, Rudolf Giles, Graham Relton, Caroline Riboli, Elio Boeing, Heiner Ueland, Per Magne Severi, Gianluca and Brennan, Paul
- Abstract
Background The etiology of renal cell carcinoma (RCC) is only partially understood, but a metabolic component appears likely. We investigated biomarkers of one-carbon metabolism and RCC onset and survival. Methods The European Prospective Investigation into Cancer and Nutrition (EPIC) recruited 385 747 participants with blood samples between 1992 and 2000, and this analysis included 556 RCC case-control pairs. A subsequent replication study included 144 case-control pairs nested within the Melbourne Collaborative Cohort Study (MCCS). Plasma concentrations of vitamin B2, vitamin B6, folate, vitamin B12, methionine and homocysteine were measured in prediagnostic samples and evaluated with respect to RCC risk using conditional and unconditional logistic regression models, and to all-cause mortality in RCC cases using Cox regression models. All statistical tests were two-sided. Results EPIC participants with higher plasma concentrations of vitamin B6 had lower risk of RCC, the odds ratio comparing the 4th and 1st quartiles (OR4vs1) being 0.40 95% confidence interval [CI] = 0.28 to 0.57, P-trend < .001. We found similar results after adjusting for potential confounders (adjusted P-trend < .001). In survival analysis, the hazard ratio for all-cause mortality in RCC cases when comparing the 4th and 1st quartiles (HR4vs1) of vitamin B6 was 0.57 (95% CI = 0.37 to 0.87, P-trend < .001). Subsequent replication of these associations within the MCCS yielded very similar results for both RCC risk (OR4vs1 = 0.47, 95% CI = 0.23 to 0.99, P-trend = .07) and all-cause mortality (HR4vs1 = 0.56, 95% CI = 0.27 to 1.17, P-trend = .02). No association was evident for the other measured biomarkers. Conclusion Study participants with higher circulating concentrations of vitamin B6 had lower risk of RCC and improved survival following diagnosis in two independent cohorts.
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- 2014
31. Dietary Intakes and Risk of Lymphoid and Myeloid Leukemia in the European Prospective Investigation into Cancer and Nutrition (EPIC)
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Hosnijeh, Fatemeh Saberi Peeters, Petra Romieu, Isabelle and Kelly, Rachel Riboli, Elio Olsen, Anja Tjonneland, Anne and Fagherazzi, Guy Clavel-Chapelon, Francoise Dossus, Laure and Nieters, Alexandra Teucher, Birgit Trichopoulou, Antonia and Naska, Androniki Valanou, Elisavet Mattiello, Amalia Sieri, Sabina Parr, Christine L. Engeset, Dagrun Skeie, Guri and Dorronsoro, Miren Barricarte, Aurelio Sanchez, Maria-Jose and Ericson, Ulrika Sonestedt, Emily Bueno-de-Mesquita, H. Bas and Ros, Martine M. Travis, Ruth C. Key, Timothy J. Vineis, Paolo Vermeulen, Roel
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hemic and lymphatic diseases - Abstract
The etiology of leukemias cannot entirely be explained by known risk factors, including ionizing radiation, benzene exposure, and infection with human T cell leukemia virus. A number of studies suggested that diet influences the risk of adult leukemias. However, results have been largely inconsistent. We examined the potential association between dietary factors and risk of leukemias among participants of the European Prospective Investigation into Cancer and Nutrition study. Among the 477,325 participants with mean follow-up of 11.34yr (SD = 2.47), 773 leukemias (373 and 342 cases of lymphoid and myeloid leukemia, respectively) were identified. Diet over the previous 12 mo was assessed at baseline using a validated country-specific dietary questionnaire. Cox proportional hazards regression was used to explore the association between dietary factors that have previously been associated with leukemia risk, including red and processed meat, poultry, offal, fish, dairy products, vegetables, fruits, and seeds/nuts, and risk of both lymphoid and myeloid leukemias. No significant associations were observed between dietary measures and total, lymphoid, and myeloid leukemias. Additional subtype analyses showed no dietary association with risk of major subtypes of leukemias. In summary, this study did not support a possible link between selected dietary factors and risk of leukemias.
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- 2014
32. Plasma carotenoids, vitamin C, retinol and tocopherols levels and pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition: A nested case-control study Plasma micronutrients and pancreatic cancer risk
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Unit Opleiding MDL, MS MDL 1, Cancer, MS MDL Oncologie, UMC Utrecht, Epi Kanker Team A, JC onderzoeksprogramma Kanker, Jeurnink, Suzanne M., Ros, Martine M., Leenders, Max, Van Duijnhoven, Franzel J B, Siersema, Peter D., Jansen, Eugene H J M, Van Gils, Carla H., Bakker, Marije F., Overvad, Kim, Roswall, Nina, Tjønneland, Anne, Boutron-Ruault, Marie Christine, Racine, Antoine, Cadeau, Claire, Grote, Verena, Kaaks, Rudolf, Aleksandrova, Krasimira, Boeing, Heiner, Trichopoulou, Antonia, Benetou, Vasiliki, Valanou, Elisavet, Palli, Domenico, Krogh, Vittorio, Vineis, Paolo, Tumino, Rosario, Mattiello, Amalia, Weiderpass, Elisabete, Skeie, Guri, Castão, José María Huerta, Duell, Eric J., Barricarte, Aurelio, Molina-Montes, Esther, Argüelles, Marcial, Dorronsoro, Mire, Johansen, Dorthe, Lindkvist, Björn, Sund, Malin, Crowe, Francesca L., Khaw, Kay Tee, Jenab, Mazda, Fedirko, Veronika, Riboli, E., Bueno-De-Mesquita, H. Bas, Unit Opleiding MDL, MS MDL 1, Cancer, MS MDL Oncologie, UMC Utrecht, Epi Kanker Team A, JC onderzoeksprogramma Kanker, Jeurnink, Suzanne M., Ros, Martine M., Leenders, Max, Van Duijnhoven, Franzel J B, Siersema, Peter D., Jansen, Eugene H J M, Van Gils, Carla H., Bakker, Marije F., Overvad, Kim, Roswall, Nina, Tjønneland, Anne, Boutron-Ruault, Marie Christine, Racine, Antoine, Cadeau, Claire, Grote, Verena, Kaaks, Rudolf, Aleksandrova, Krasimira, Boeing, Heiner, Trichopoulou, Antonia, Benetou, Vasiliki, Valanou, Elisavet, Palli, Domenico, Krogh, Vittorio, Vineis, Paolo, Tumino, Rosario, Mattiello, Amalia, Weiderpass, Elisabete, Skeie, Guri, Castão, José María Huerta, Duell, Eric J., Barricarte, Aurelio, Molina-Montes, Esther, Argüelles, Marcial, Dorronsoro, Mire, Johansen, Dorthe, Lindkvist, Björn, Sund, Malin, Crowe, Francesca L., Khaw, Kay Tee, Jenab, Mazda, Fedirko, Veronika, Riboli, E., and Bueno-De-Mesquita, H. Bas
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- 2015
33. Reliability of Selected Antioxidants and Compounds Involved in One-Carbon Metabolism in Two Dutch Cohorts
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Leenders, Max, Ros, Martine M., Sluijs, Ivonne, Boshuizen, Hendriek C., Van Gils, Carla H., Jansen, Eug̀ene H J M, Bueno-de-Mesquita, H. Bas, LS IRAS EEPI GRA (Gezh.risico-analyse), and LS IRAS EEPI GRA (Gezh.risico-analyse)
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Male ,Cancer Research ,Homocysteine ,Nutrition and Disease ,Intraclass correlation ,design ,Physiology ,Tocopherols ,Medicine (miscellaneous) ,Ascorbic Acid ,Wiskundige en Statistische Methoden - Biometris ,Antioxidants ,Cohort Studies ,chemistry.chemical_compound ,c-reactive protein ,Voeding en Ziekte ,oxidative stress ,Vitamin A ,Netherlands ,Nutrition and Dietetics ,Chemistry ,Retinol ,carotenoids ,Middle Aged ,tocopherol ,European Prospective Investigation into Cancer and Nutrition ,Vitamin B 12 ,Oncology ,Female ,retinol ,Adult ,Regression dilution ,Nutritional Status ,nutritional biomarkers ,Young Adult ,Folic Acid ,Humans ,cancer ,Vitamin B12 ,Mathematical and Statistical Methods - Biometris ,Aged ,Molecular epidemiology Aetiology, screening and detection [NCEBP 1] ,Vitamin C ,Carbon ,Vitamin B 6 ,Diet ,Risk Estimate ,Immunology ,plasma homocysteine ,serum ,Biomarkers - Abstract
Contains fulltext : 117571.pdf (Publisher’s version ) (Closed access) Many epidemiological studies assess nutritional status based on single blood measurements, without verifying if these remain reliable over repeated measurements. This study assessed the reliability over a period of 2 to 5 yr of plasma carotenoids, vitamin C, retinol, tocopherols, and serum compounds involved in 1-carbon metabolism in a subsample of Dutch participants of European Prospective Investigation into Cancer and Nutrition (EPIC). Blood samples from 38 men from MORGEN-EPIC and 35 women from Prospect-EPIC were collected between 1993 and 1997 and again after 2 to 5 yr. The reliability of plasma carotenoids, retinol, vitamin C, and tocopherols, and of serum folate, homocysteine, and vitamins B6 and B12 was estimated using an intraclass correlation coefficient (ICC). Serum homocysteine and vitamin B12 were highly reliable biomarkers, with ICCs of 0.91 and 0.75, respectively. All other analyzed biomarkers had a slight or fair reliability over several years (ICCs ranged from 0.17 to 0.56). Most examined biomarkers showed reliability values that may lead to considerable attenuation of the risk estimate when used as exposure assessment in a risk model. If multiple measurements are not available, the risk estimates can be adjusted for the regression dilution using the ICC as adjustment coefficient.
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- 2013
34. Fruit and Vegetable Consumption and Mortality European Prospective Investigation Into Cancer and Nutrition
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Leenders, Max Sluijs, Ivonne Ros, Martine M. Boshuizen, Hendriek C. Siersema, Peter D. Ferrari, Pietro Weikert, Cornelia Tjonneland, Anne Olsen, Anja Boutron-Ruault, Marie-Christine Clavel-Chapelon, Franoise Nailler, Laura and Teucher, Birgit Li, Kuanrong Boeing, Heiner Bergmann, Manuela M. Trichopoulou, Antonia Lagiou, Pagona and Trichopoulos, Dimitrios Palli, Domenico Pala, Valeria and Panico, Salvatore Tumino, Rosario Sacerdote, Carlotta and Peeters, Petra H. M. van Gils, Carla H. Lund, Eiliv Engeset, Dagrun Redondo, Maria Luisa Agudo, Antonio Sanchez, Maria Jose Navarro, Carmen Ardanaz, Eva Sonestedt, Emily and Ericson, Ulrika Nilsson, Lena Maria Khaw, Kay-Tee Warcham, Nicholas J. Key, Timothy J. Crowe, Francesca L. Romieu, Isabelle Gunter, Marc J. Gallo, Valentina Overvad, Kim and Riboli, Elio Bueno-de-Mesquita, H. Bas
- Abstract
In this study, the relation between fruit and vegetable consumption and mortality was investigated within the European Prospective Investigation Into Cancer and Nutrition. Survival analyses were performed, including 451,151 participants from 10 European countries, recruited between 1992 and 2000 and followed until 2010. Hazard ratios, rate advancement periods, and preventable proportions to respectively compare risk of death between quartiles of consumption, to estimate the period by which the risk of death was postponed among high consumers, and to estimate proportions of deaths that could be prevented if all participants would shift their consumption 1 quartile upward. Consumption of fruits and vegetables was inversely associated with all-cause mortality (for the highest quartile, hazard ratio = 0.90, 95% confidence interval (CI): 0.86, 0.94), with a rate advancement period of 1.12 years (95% CI: 0.70, 1.54), and with a preventable proportion of 2.95%. This association was driven mainly by cardiovascular disease mortality (for the highest quartile, hazard ratio = 0.85, 95% CI: 0.77, 0.93). Stronger inverse associations were observed for participants with high alcohol consumption or high body mass index and suggested in smokers. Inverse associations were stronger for raw than for cooked vegetable consumption. These results support the evidence that fruit and vegetable consumption is associated with a lower risk of death.
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- 2013
35. Anthropometric characteristics and risk of lymphoid and myeloid leukemia in the European Prospective Investigation into Cancer and Nutrition (EPIC)
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Hosnijeh, Fatemeh Saberi Romieu, Isabelle Gallo, Valentina and Riboli, Elio Tjonneland, Anne Halkjaer, Jytte Fagherazzi, Guy Clavel-Chapelon, Francoise Dossus, Laure Lukanova, Annie and Kaaks, Rudolf Trichopoulou, Antonia Lagiou, Pagona and Katsoulis, Michael Panico, Salvatore Tagliabue, Giovanna and Bonet, Catalina Dorronsoro, Miren Maria Huerta, Jose and Ardanaz, Eva Sanchez, Maria-Jose Johansen, Dorthe Borgquist, Signe Peeters, Petra Bueno-de-Mesquita, H. Bas Ros, Martine M. Travis, Ruth C. Key, Timothy J. Vineis, Paolo and Vermeulen, Roel
- Subjects
hemic and lymphatic diseases - Abstract
Overweight and obesity have been suggested as a risk factor for leukemia. Impaired immune function associated with obesity, increased insulin-like growth factor-I activity and stimulating effects of leptin suggest a possible biological link between anthropometric measures and leukemia. However, evidence from epidemiological studies has been inconsistent. We examined the potential association between prospective measurements of body size and risk of leukemia among participants of the European Prospective Investigation into Cancer and Nutrition (EPIC). During follow-up (mean = 11.52 years, standard deviation = 2.63), 671 leukemia (lymphoid leukemia = 50.1 %, myeloid leukemia = 43.2 %) cases were identified. Anthropometric measures including weight, height, body mass index (BMI), waist circumference (WC), hip circumference, and waist-to-hip ratio (WHR) were measured. Cox proportional hazard models were used to explore the association between anthropometric measures and risk of leukemia. No associations were observed between anthropometric measures and total leukemia, and lymphoid leukemia. Risk of myeloid leukemia significantly increased for higher categories of BMI and WC among women. Analyses by subtype of myeloid leukemia showed an increased risk of acute myeloid leukemia (AML) for higher categories of WHR among women. This association seemed to be reversed for chronic myeloid leukemia. No association between anthropometric measures and myeloid leukemia were observed among men except an increased risk of AML with height. The study showed no associations between anthropometric measures and total leukemia, and lymphoid leukemia among men and women. A possible association between BMI as general obesity and WC as abdominal obesity and increased risk of myeloid leukemia among women were observed.
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- 2013
36. North-south gradients in plasma concentrations of B-vitamins and other components of one-carbon metabolism in Western Europe: results from the European Prospective Investigation into Cancer and Nutrition (EPIC) Study
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Eussen, Simone J. P. M. Nilsen, Roy M. Midttun, Oivind and Hustad, Steinar IJssennagger, Noortje Meyer, Klaus and Fredriksen, Ase Ulvik, Arve Ueland, Per M. Brennan, Paul and Johansson, Mattias Bueno-de-Mesquita, Bas Vineis, Paolo and Chuang, Shu-Chun Boutron-Ruault, Marie Christine Dossus, Laure and Perquier, Florence Overvad, Kim Teucher, Birgit Grote, Verena A. Trichopoulou, Antonia Adarakis, George Plada, Maria Sieri, Sabina Tumino, Rosario Santucci de Magistris, Maria Ros, Martine M. Peeters, Petra H. M. Luisa Redondo, Maria Zamora-Ros, Raul Chirlaque, Maria-Dolores Ardanaz, Eva and Sonestedt, Emily Ericson, Ulrika Schneede, Joern van Guelpen, Bethany Wark, Petra A. Gallo, Valentina Norat, Teresa Riboli, Elio Vollset, Stein Emil
- Abstract
Different lifestyle patterns across Europe may influence plasma concentrations of B-vitamins and one-carbon metabolites and their relation to chronic disease. Comparison of published data on one-carbon metabolites in Western European regions is difficult due to differences in sampling procedures and analytical methods between studies. The present study aimed, to compare plasma concentrations of one-carbon metabolites in Western European regions with one laboratory performing all biochemical analyses. We performed the present study in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort among 5446 presumptively healthy individuals. Quantile regression was used to compare sex-specific median concentrations between Northern (Denmark and Sweden), Central (France, Germany, The Netherlands and United Kingdom) and Southern (Greece, Spain and Italy) European regions. The lowest folate concentrations were observed in Northern Europe (men, 10.4 nmol/l; women, 10.7 nmol/l) and highest concentrations in Central Europe. Cobalamin concentrations were slightly higher in Northern Europe (men, 330 pmol/l; women, 352 pmol/l) compared with Central and Southern Europe, but did not show a clear north-south gradient. Vitamin B-2 concentrations were highest in Northern Europe (men, 22.2 nmol/l; women, 26.0 nmol/l) and decreased towards Southern Europe (P-trend < 0.001). Vitamin B-6 concentrations were highest in Central Europe in men (77.3 nmol/l) and highest in the North among women (70.4 nmol/l), with decreasing concentrations towards Southern Europe in women (P-trend < 0.001). In men, concentrations of serine, glycine and sarcosine increased from the north to south. In women, sarcosine increased from Northern to Southern Europe. These findings may provide relevant information for the study of regional differences of chronic disease incidence in association with lifestyle.
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- 2013
37. Dietary fiber intake and risk of hormonal receptor-defined breast cancer in the European Prospective Investigation into Cancer and Nutrition study
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Ferrari, Pietro Rinaldi, Sabina Jenab, Mazda Lukanova, Annekatrin Olsen, Anja Tjonneland, Anne Overvad, Kim and Clavel-Chapelon, Francoise Fagherazzi, Guy Touillaud, Marina and Kaaks, Rudolf von Ruesten, Anne Boeing, Heiner Trichopoulou, Antonia Lagiou, Pagona Benetou, Vassiliki Grioni, Sara and Panico, Salvatore Masala, Giovanna Tumino, Rosario Polidoro, Silvia Bakker, Marije F. van Gils, Carla H. Ros, Martine M. and Bueno-de-Mesquita, H. Bas Krum-Hansen, Sanda Engeset, Dagrun and Skeie, Guri Pilar, Amiano Sanchez, Maria-Jose Buckland, Genevieve Ardanaz, Eva Chirlaque, Dolores Rodriguez, Laudina and Travis, Ruth Key, Tim Khaw, Kay-Tee Wareham, Nicholas J. and Sund, Malin Lenner, Per Slimani, Nadia Norat, Teresa and Aune, Dagfinn Riboli, Elio Romieu, Isabelle
- Abstract
Background: Limited scientific evidence has characterized the association between dietary fiber intake and risk of breast cancer (BC) by menopausal status and hormone receptor expression in tumors. ‘ Objective: We investigated the relation between total dietary fiber and its main food sources (vegetables, fruit, cereals, and legumes) and BC risk by using data from the European Prospective Investigation into Cancer and Nutrition (EPIC). Design: A total of 11,576 invasive BC cases in 334,849 EPIC women mostly aged 35-70 y at baseline were identified over a median follow-up of 11.5 y. Dietary fiber was estimated from country-specific dietary questionnaires. Multivariable Cox proportional hazards regression models were used to quantify the association between dietary variables and BC risk with energy adjustment by using the residual method. Subgroup analyses were performed by menopausal status and estrogen receptor (ER) and progesterone receptor (PR) expression in tumors. Results: BC risk was inversely associated with intakes of total dietary fiber [hazard ratio comparing fifth quintile to first quintile (HRQ5-Q1): 0.95; 95% CI: 0.89, 1.01; P-trend = 0.03] and fiber from vegetables (0.90; 0.84, 0.96; P-trend < 0.01) but not with fiber from fruit, cereals, or legumes. Overall, associations were homogeneous by menopausal status and ER and PR expression in tumors. For vegetable fiber, stronger associations were observed for estrogen receptor-negative and progesterone receptor-negative (HRQ5-Q1: 0.74; 95% CI: 0.59, 0.93; P-trend = 0.01) than for estrogen receptor-positive and progesterone receptor-positive tumors (0.92: 0.81, 1.03; P-trend = 0.05), with P-heterogeneity = 0.09. Conclusion: Diets rich in dietary fiber and, particularly, fiber from vegetables may be associated with a small reduction in risk of BC, independently of menopausal status. Am J Clin Nutr 2013;97:344-53.
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- 2013
38. Macronutrient intake and risk of urothelial cell carcinoma in the European prospective investigation into cancer and nutrition
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Allen, Naomi E. Appleby, Paul N. Key, Timothy J. and Bueno-de-Mesquita, H. B. Ros, Martine M. Kiemeney, Lambertus A. L. M. Tjonneland, Anne Roswall, Nina Overvad, Kim and Weikert, Steffen Boeing, Heiner Chang-Claude, Jenny Teucher, Birgit Panico, Salvatore Sacerdote, Carlotta Tumino, Rosario and Palli, Domenico Sieri, Sabina Peeters, Petra Ramon Quiros, Jose Jakszyn, Paula Molina-Montes, Esther Chirlaque, Maria-Dolores Ardanaz, Eva Dorronsoro, Miren Khaw, Kay-Tee and Wareham, Nick Ljungberg, Borje Hallmans, Goran and Ehrnstrom, Roy Ericson, Ulrika Torhild Gram, Inger Parr, Christine L. Trichopoulou, Antonia Karapetyan, Tina Dilis, Vardis Clavel-Chapelon, Francoise Boutron-Ruault, Marie-Christine Fagherrazzi, Guy Romieu, Isabelle Gunter, Marc J. Riboli, Elio
- Abstract
Previous studies have suggested that dietary factors may be important in the development of bladder cancer. We examined macronutrient intake in relation to risk of urothelial cell carcinoma among 469,339 men and women in the European Prospective Investigation into Cancer and Nutrition. Associations were examined using Cox regression, stratified by sex, age at recruitment and centre and further adjusted for smoking status and duration, body mass index and total energy intake. After an average of 11.3 years of follow-up, 1,416 new cases of urothelial cell carcinoma were identified. After allowing for measurement error, a 3% increase in the consumption of energy intake from animal protein was associated with a 15% higher risk (95% confidence interval [CI]: 330%; ptrend = 0.01) and a 2% increase in energy from plant protein intake was associated with a 23% lower risk (95% CI: 367%, ptrend = 0.006). Dietary intake of fat, carbohydrate, fibre or calcium was not associated with risk. These findings suggest that animal and/or plant protein may affect the risk of urothelial cell carcinoma, and examination of these associations in other studies is needed.
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- 2013
39. Fruit and vegetable consumption and risk of aggressive and non-aggressive urothelial cell carcinomas in the European Prospective Investigation into Cancer and Nutrition
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Ros, Martine M. Bueno-de-Mesquita, H. Bas Kampman, Ellen and Buchner, Frederike L. Aben, Katja K. H. Egevad, Lars and Overvad, Kim Tjonneland, Anne Roswall, Nina Clavel-Chapelon, Francoise Boutron-Ruault, Marie Christine Morois, Sophie and Kaaks, Rudolf Teucher, Birgit Weikert, Steffen von Ruesten, Anne Trichopoulou, Antonia Naska, Androniki Benetou, Vassiliki Saieva, Calogero Pala, Valeria Ricceri, Fulvio and Tumino, Rosario Mattiello, Amalia Peeters, Petra H. M. van Gils, Carla H. Gram, Inger T. Engeset, Dagrun Chirlaque, Maria-Dolores Ardanazx, Eva Rodriguez, Laudina Amanio, Pilar and Gonzalez, Carlos A. Jose Sanchez, Maria Ulmert, David and Ernstrom, Roy Ljungberg, Borje Allen, Naomi E. Key, Timothy J. Khaw, Kee-Tee Wareham, Nick Slimani, Nadia Romieu, Isabelle Kiemeney, Lambertus A. Riboli, Elio
- Abstract
Background: Many epidemiological studies have examined fruit and vegetable consumption in relation to the risk of urothelial cell carcinoma (UCC) of the bladder, but results are inconsistent. The association between fruit and vegetable consumption and UCC risk may vary by bladder tumour aggressiveness. Therefore, we examined the relation between fruit and vegetable consumption and the risk of aggressive and non-aggressive UCC in the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: After 8.9 years of follow-up, 947 UCC were diagnosed among 468,656 EPIC participants. Of these, 421 could be classified as aggressive UCC and 433 as non-aggressive UCC cases. At recruitment, fruit and vegetable consumption was assessed by validated dietary questionnaires. Multivariable hazard ratios were estimated using Cox regression stratified by age, sex and center and adjusted for smoking status, duration and intensity of smoking, and energy intake. Results: Total consumption of fruits and vegetables was not associated with aggressive UCC nor with non-aggressive UCC. A 25 g/day increase in leafy vegetables and grapes consumption was associated with a reduced risk of non-aggressive UCC (hazard ratio (HR) 0.88; 95% confidence interval (CI) 0.78-1.00 and HR 0.87; 95% CI 0.77-0.98, respectively), while the intake of root vegetables was inversely associated with risk of aggressive UCC (HR 0.87; 95% CI 0.77-0.98). Conclusion: Our study did not confirm a protective effect of total fruit and/or vegetable consumption on aggressive or non-aggressive UCC. High consumption of certain types of vegetables and of fruits may reduce the risk of aggressive or non-aggressive UCC; however chance findings cannot be excluded. (C) 2012 Elsevier Ltd. All rights reserved.
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- 2012
40. Fiber intake and total and cause-specific mortality in the European Prospective Investigation into Cancer and Nutrition cohort
- Author
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Chuang, Shu-Chun Norat, Teresa Murphy, Neil Olsen, Anja and Tjonneland, Anne Overvad, Kim Boutron-Ruault, Marie Christine and Perquier, Florence Dartois, Laureen Kaaks, Rudolf and Teucher, Birgit Bergmann, Manuela M. Boeing, Heiner and Trichopoulou, Antonia Lagiou, Pagona Trichopoulos, Dimitrios and Grioni, Sara Sacerdote, Carlotta Panico, Salvatore Palli, Domenico Tumino, Rosario Peeters, Petra H. M. and Bueno-de-Mesquita, Bas Ros, Martine M. Brustad, Magritt and Asli, Lene Angell Skeie, Guri Quiros, J. Ramon Gonzalez, Carlos A. Sanchez, Maria-Jose Navarro, Carmen Aicua, Eva Ardanaz Dorronsoro, Miren Drake, Isabel Sonestedt, Emily and Johansson, Ingegerd Hallmans, Goeran Key, Timothy Crowe, Francesca Khaw, Kay-Tee Wareham, Nicholas Ferrari, Pietro and Slimani, Nadia Romieu, Isabelle Gallo, Valentina Riboli, Elio Vineis, Paolo
- Abstract
Background: Previous studies have shown that high fiber intake is associated with lower mortality. However, little is known about the association of dietary fiber with specific causes of death other than cardiovascular disease (CVD). Objective: The aim of this study was to assess the relation between fiber intake, mortality, and cause-specific mortality in a large European prospective study of 452,7 I 7 men and women. Design: HRs and 95% CIs were estimated by using Cox proportional hazards models, stratified by age, sex, and center and adjusted for education, smoking, alcohol consumption, BMI, physical activity, total energy intake, and, in women, ever use of menopausal hormone therapy. Results: During a mean follow-up of 12.7 y, a total of 23,582 deaths were recorded. Fiber intake was inversely associated with total mortality (HRper (10-g/d) (increase): 0.90; 95% Cl: 0.88, 0.92); with mortality from circulatory (HRper (10-g/d increase): 0.90 and 0.88 for men and women, respectively), digestive (HR: 0.61 and 0.64), respiratory (HR: 0.77 and 0.62), and non-CVD noncancer inflammatory (HR: 0.85 and 0.80) diseases; and with smoking-related cancers (HR: 0.86 and 0.89) but not with non-smoking-related cancers (HR: 1.05 and 0.97). The associations were more evident for fiber from cereals and vegetables than from fruit. The associations were similar across BMI and physical activity categories but were stronger in smokers and participants who consumed >18 g alcohol/d. Conclusions: Higher fiber intake is associated with lower mortality, particularly from circulatory, digestive, and non-CVD noncancer inflammatory diseases. Our results support current recommendations of high dietary fiber intake for health maintenance. Am J Clin Nutr 2012;96:164-74.
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- 2012
41. Plasma carotenoids and vitamin C concentrations and risk of urothelial cell carcinoma in the European Prospective Investigation into Cancer and Nutrition
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Ros, Martine M. Bueno-de-Mesquita, H. Bas Kampman, Ellen and Aben, Katja K. H. Buechner, Frederike L. Jansen, Eugene H. J. M. and van Gils, Carla H. Egevad, Lars Overvad, Kim Tjonneland, Anne Roswall, Nina Boutron-Ruault, Marie Christine Kvaskoff, Marina Perquier, Florence Kaaks, Rudolf Chang-Claude, Jenny and Weikert, Steffen Boeing, Heiner Trichopoulou, Antonia and Lagiou, Pagona Dilis, Vardis Palli, Domenico Pala, Valeria and Sacerdote, Carlotta Tumino, Rosario Panico, Salvatore and Peeters, Petra H. M. Gram, Inger T. Skeie, Guri Huerta, Jose Maria Barricarte, Aurelio Quiros, Jose Ramon Sanchez, Maria Jose Buckland, Genevieve Larranaga, Nerea Ehrnstroem, Roy and Wallstroem, Peter Jungberg, Boerje L. Hallmans, Goeran and Key, Timothy J. Allen, Naomi E. Khaw, Kay-Tee Wareham, Nick and Brennan, Paul Riboli, Elio Kiemeney, Lambertus A.
- Abstract
Background: Published associations between dietary carotenoids and vitamin C and bladder cancer risk are inconsistent. Biomarkers may provide more accurate measures of nutrient status. Objective: We investigated the association between plasma carotenoids and vitamin C and risk of urothelial cell carcinoma (UCC) in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition. Design: A total of 856 patients with newly diagnosed UCC were matched with 856 cohort members by sex, age at baseline, study center, date and time of blood collection, and fasting status. Plasma carotenoids (alpha- and beta-carotene, beta-cryptoxanthin, lycopene, lutein, and zeaxanthin) were measured by using reverse-phase HPLC, and plasma vitamin C was measured by using a colorimetric assay. Incidence rate ratios (IRRs) were estimated by using conditional logistic regression with adjustment for smoking status, duration, and intensity. Results: UCC risk decreased with higher concentrations of the sum of plasma carotenoids (IRR for the highest compared with the lowest quartile: 0.64; 95% CI: 0.44, 0.93; P-trend = 0.04). Plasma beta-carotene was inversely associated with aggressive UCC (IRR: 0.51; 95% CI: 0.30, 0.88; P-trend = 0.02). Plasma lutein was inversely associated with risk of nonaggressive UCC (IRR: 0.56; 95% CI: 0.32, 0.98; P-trend = 0.05). No association was observed between plasma vitamin C and risk of UCC. Conclusions: Although residual confounding by smoking or other factors cannot be excluded, higher concentrations of plasma carotenoids may reduce risk of UCC, in particular aggressive UCC. Plasma lutein may reduce risk of nonaggressive UCC. Am J Clin Nutr 2012;96:902-10.
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- 2012
42. Postmenopausal Serum Sex Steroids and Risk of Hormone Receptor-Positive and -Negative Breast Cancer: a Nested Case-Control Study
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James, Rebecca E. Lukanova, Annekatrin Dossus, Laure Becker, Susen Rinaldi, Sabina Tjonneland, Anne Olsen, Anja and Overvad, Kim Mesrine, Sylvie Engel, Pierre Clavel-Chapelon, Francoise Chang-Claude, Jenny Vrieling, Alina Boeing, Heiner and Schuetze, Madlen Trichopoulou, Antonia Lagiou, Pagona and Trichopoulos, Dimitrios Palli, Domenico Krogh, Vittorio and Panico, Salvatore Tumino, Rosario Sacerdote, Carlotta and Rodriguez, Laudina Buckland, Genevieve Sanchez, Maria-Jose and Amiano, Pilar Ardanaz, Eva Bueno-de-Mesquita, Bas Ros, Martine M. van Gils, Carla H. Peeters, Petra H. Khaw, Kay-Tee Wareham, Nick Key, Timothy J. Allen, Naomi E. and Romieu, Isabelle Siddiq, Afshan Cox, David Riboli, Elio and Kaaks, Rudolf
- Abstract
Prediagnostic endogenous sex steroid hormone levels have well established associations with overall risk of breast cancer. While evidence toward the existence of distinct subtypes of breast cancer accumulates, few studies have investigated the associations of sex steroid hormone levels with risk of hormone receptor [estrogen receptor (ER) and/or progesterone receptor (PR)] defined breast cancer. In a case-control study nested within the EPIC cohort (European Prospective Investigation into Cancer and Nutrition), estradiol, testosterone, and sex hormone-binding globulin levels were measured in prediagnostic serum samples from postmenopausal women not using hormone replacement therapy at blood donation. A total of 554 women who developed invasive breast cancer with information on receptor status were matched with 821 control subjects. Conditional logistic regression models estimated breast cancer risk with hormone concentrations according to hormone receptor status of the tumor. Sex steroid hormones were associated with risks of not only ER+PR+ breast cancer [estradiol OR for highest vs. lowest tertile = 2.91 (95% CI: 1.62-5.23), P-trend 0.002; testosterone OR = 2.27 (95% CI: 1.35-3.81), P-trend 0.002] but also of ER-PR- breast cancer [estradiol OR = 2.11 (95% CI: 1.00-4.46), P-trend = 0.05; testosterone OR = 2.06 (95% CI: 0.95-4.46), P-trend = 0.03], with associations appearing somewhat stronger in the receptor-positive disease. Serum androgens and estrogens are associated with risks of both hormone receptor-negative as well as receptor-positive breast tumors. Further research is needed to establish through which molecular pathways, and during which evolutionary stages of development, androgens and estrogens can promote the occurrence of both receptor-positive and -negative clinical breast tumors. Cancer Prev Res; 4(10); 1626-35. (C)2011 AACR.
- Published
- 2011
43. Fluid intake and the risk of urothelial cell carcinomas in the European Prospective Investigation into Cancer and Nutrition (EPIC)
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Ros, Martine M. Bueno-de-Mesquita, H. B. Bas Buchner, Frederike L. Aben, Katja K. H. Kampman, Ellen Egevad, Lars and Overvad, Kim Tjonneland, Anne Roswall, Nina Clavel-Chapelon, Francoise Kaaks, Rudolf Chang-Claude, Jenny Boeing, Heiner and Weikert, Steffen Trichopoulou, Antonia Orfanos, Philippos and Stasinopulou, Georgia Saieva, Calogero Krogh, Vittorio and Vineis, Paolo Tumino, Rosario Mattiello, Amalia Peeters, Petra H. M. van Duijnhoven, Franzel J. B. Lund, Eiliv Gram, Inger T. Chirlaque, Maria D. Barricarte, Aurelio Rodriguez, Laudina Molina, Esther Gonzalez, Carlos Dorronsoro, Miren and Manjer, Jonas Ehrnstrom, Roy Ljungberg, Borje Allen, Naomi E. Roddam, Andrew W. Khaw, Kay-Tee Wareham, Nick and Boffetta, Paolo Slimani, Nadia Michaud, Dominique S. and Kiemeney, Lambertus A. L. M. Riboli, Elio
- Abstract
Results from previous studies investigating the association between fluid intake and urothelial cell carcinomas (UCC) are inconsistent. We evaluated this association among 233,236 subjects in the European Prospective Investigation into Cancer and Nutrition (EPIC), who had adequate baseline information on water and total fluid intake. During a mean follow-up of 9.3 years, 513 first primary UCC occurred. At recruitment, habitual fluid intake was assessed by a food frequency questionnaire. Multivariable hazard ratios were estimated using Cox regression stratified by age, sex and center and adjusted for energy intake, smoking status, duration of smoking and lifetime intensity of smoking. When using the lowest tertile of intake as reference, total fluid intake was not associated with risk of all UCC (HR 1.12; 95% CI 0.86-1.45, p-trend = 0.42) or with risk of prognostically high-risk UCC (HR 1.28; 95% CI 0.85-1.93, p-trend = 0.27) or prognostically low-risk UCC (HR 0.93; 95% CI 0.65-1.33, p-trend = 0.74). No associations were observed between risk of UCC and intake of water, coffee, tea and herbal tea and milk and other dairy beverages. For prognostically low-risk UCC suggestions of an inverse association with alcoholic beverages and of a positive association with soft drinks were seen. Increased risks were found for all UCC and prognostically low-risk UCC with higher intake of fruit and vegetable juices. In conclusion, total usual fluid intake is not associated with UCC risk in EPIC. The relationships observed for some fluids may be due to chance, but further investigation of the role of all types of fluid is warranted.
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- 2011
44. Alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
- Author
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Duell, Eric J. Travier, Noemie Lujan-Barroso, Leila and Clavel-Chapelon, Francoise Boutron-Ruault, Marie-Christine and Morois, Sophie Palli, Domenico Krogh, Vittorio Panico, Salvatore Tumino, Rosario Sacerdote, Carlotta Ramon Quiros, J. Sanchez-Cantalejo, Emilio Navarro, Carmen Barricarte Gurrea, Aurelio Dorronsoro, Miren Khaw, Kay-Tee Allen, Naomi E. Key, Timothy J. Bueno-de-Mesquita, H. Bas Ros, Martine M. and Numans, Mattijs E. Peeters, Petra H. M. Trichopoulou, Antonia Naska, Androniki Dilis, Vardis Teucher, Birgit and Kaaks, Rudolf Boeing, Heiner Schuetze, Madlen Regner, Sara and Lindkvist, Bjoern Johansson, Ingegerd Hallmans, Goran and Overvad, Kim Egeberg, Rikke Tjonneland, Anne Lund, Eiliv and Weiderpass, Elisabete Braaten, Tonje Romieu, Isabelle and Ferrari, Pietro Jenab, Mazda Stenling, Roger Aune, Dagfinn and Norat, Teresa Riboli, Elio Gonzalez, Carlos A.
- Abstract
Background: Gastric cancer (GC) is the second leading cause of cancer death worldwide. The association between alcohol consumption and GC has been investigated in numerous epidemiologic studies with inconsistent results. Objective: We evaluated the association between alcohol consumption and GC risk. Design: We conducted a prospective analysis in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, which included 444 cases of first primary gastric adenocarcinoma. HRs and 95% CIs for GC were estimated by using multivariable Cox proportional hazards regression for consumption of pure ethanol in grams per day, with stratification by smoking status, anatomic subsite (cardia, noncardia), and histologic subtype (diffuse, intestinal). In a subset of participants, results were further adjusted for baseline Helicobacter pylori serostatus. Results: Heavy (compared with very light) alcohol consumption (>= 60 compared with 0.1-4.9 g/d) at baseline was positively associated with GC risk (HR: 1.65; 95% CI: 1.06, 2.58), whereas lower consumption amounts (= 30 g/d; HR: 1.75; 95% CI: 1.13, 2.73) but not for wine or liquor. Associations were primarily observed at the highest amounts of drinking in men and limited to noncardia subsite and intestinal histology; no statistically significant linear dose-response trends with GC risk were observed. Conclusion: Heavy (but not light or moderate) consumption of alcohol at baseline (mainly from beer) is associated with intestinal-type noncardia GC risk in men from the EPIC cohort. Am J Clin Nutr 2011;94:1266-75.
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- 2011
45. Variety in Fruit and Vegetable Consumption and the Risk of Lung Cancer in the European Prospective Investigation into Cancer and Nutrition
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Buchner, Frederike L. Bueno-de-Mesquita, H. Bas Ros, Martine M. and Overvad, Kim Dahm, Christina C. Hansen, Louise and Tjonneland, Anne Clavel-Chapelon, Francoise Boutron-Ruault, Marie-Christine Touillaud, Marina Kaaks, Rudolf Rohrmann, Sabine Boeing, Heiner Noethlings, Ute Trichopoulou, Antonia and Zylis, Dimosthenis Dilis, Vardis Palli, Domenico Sieri, Sabina Vineis, Paolo Tumino, Rosario Panico, Salvatore and Peeters, Petra H. M. van Gils, Carla H. Lund, Eiliv Gram, Inger T. Braaten, Tonje Sanchez, Maria-Jose Agudo, Antonio and Larranaga, Nerea Ardanaz, Eva Navarro, Carmen and Argueelles, Marcial V. Manjer, Jonas Wirfalt, Elisabet and Hallmans, Goeran Rasmuson, Torgny Key, Tim J. Khaw, Kay-Tee and Wareham, Nick Silimani, Nadia Vergnaud, Anne-Claire Xun, Wei W. Kiemeney, Lambertus A. L. M. Riboli, Elio
- Abstract
Background: We investigated whether a varied consumption of vegetables and fruits is associated with lower lung cancer risk in the European Prospective Investigation into Cancer and Nutrition study. Methods: After a mean follow-up of 8.7 years, 1,613 of 452,187 participants with complete information were diagnosed with lung cancer. Diet diversity scores (DDS) were used to quantify the variety in fruit and vegetable consumption. Multivariable proportional hazards models were used to assess the associations between DDS and lung cancer risk. All models were adjusted for smoking behavior and the total consumption of fruit and vegetables. Results: With increasing variety in vegetable subgroups, risk of lung cancer decreases [hazard ratios (HR), 0.77; 95% confidence interval (CI), 0.64-0.94 highest versus lowest quartile; P trend = 0.02]. This inverse association is restricted to current smokers (HR, 0.73; 95% CI, 0.57-0.93 highest versus lowest quartile; P trend = 0.03). In continuous analyses, in current smokers, lower risks were observed for squamous cell carcinomas with more variety in fruit and vegetable products combined (HR/two products, 0.88; 95% CI, 0.82-0.95), vegetable subgroups (HR/subgroup, 0.88; 95% CI, 0.79-0.97), vegetable products (HR/two products, 0.87; 95% CI, 0.79-0.96), and fruit products (HR/two products, 0.84; 95% CI, 0.72-0.97). Conclusion: Variety in vegetable consumption was inversely associated with lung cancer risk among current smokers. Risk of squamous cell carcinomas was reduced with increasing variety in fruit and/or vegetable consumption, which was mainly driven by the effect in current smokers. Impact: Independent from quantity of consumption, variety in fruit and vegetable consumption may decrease lung cancer risk. Cancer Epidemiol Biomarkers Prev; 19(9); 2278-86. (C) 2010 AACR.
- Published
- 2010
46. Reproductive Factors and Exogenous Hormone Use in Relation to Risk of Glioma and Meningioma in a Large European Cohort Study
- Author
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Michaud, Dominique S. Gallo, Valentina Schlehofer, Brigitte and Tjonneland, Anne Olsen, Anja Overvad, Kim Dahm, Christina C. and Kaaks, Rudolf Lukanova, Annekatrin Boeing, Heiner and Schuetze, Madlen Trichopoulou, Antonia Bamia, Christina and Kyrozis, Andreas Sacerdote, Carlotta Agnoli, Claudia Palli, Domenico Tumino, Rosario Mattiello, Amalia and Bueno-de-Mesquita, H. Bas Ros, Martine M. Peeters, Petra H. M. and van Gils, Carla H. Lund, Eiliv Bakken, Kjersti Gram, Inger T. Barricarte, Aurelio Navarro, Carmen Dorronsoro, Miren Jose Sanchez, Maria Rodriguez, Laudina Duell, Eric J. and Hallmans, Goran Melin, Beatrice S. Manjer, Jonas and Borgquist, Signe Khaw, Kay-Tee Wareham, Nick Allen, Naomi E. and Tsilidis, Konstantinos K. Romieu, Isabelle Rinaldi, Sabina and Vineis, Paolo Riboli, Elio
- Subjects
neoplasms ,nervous system diseases - Abstract
Background: The etiologies of glioma and meningioma tumors are largely unknown. Although reproductive hormones are thought to influence the risk of these tumors, epidemiologic data are not supportive of this hypothesis; however, few cohort studies have published on this topic. We examined the relation between reproductive factors and the risk of glioma and meningioma among women in the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: After a mean of 8.4 years of follow-up, 193 glioma and 194 meningioma cases were identified among 276,212 women. Information on reproductive factors and hormone use was collected at baseline. Cox proportional hazard regression was used to determine hazard ratios (HR) and 95% confidence intervals (95% CI). Results: No associations were observed between glioma or meningioma risk and reproductive factors, including age at menarche, parity, age at first birth, menopausal status, and age at menopause. A higher risk of meningioma was observed among postmenopausal women who were current users of hormone replacement therapy (HR, 1.79; 95% CI, 1.18-2.71) compared with never users. Similarly, current users of oral contraceptives were at higher risk of meningioma than never users (HR, 3.61; 95% CI, 1.75-7.46). Conclusion: Our results do not support a role for estrogens and glioma risk. Use of exogenous hormones, especially current use, seems to increase meningioma risk. However, these findings could be due to diagnostic bias and require confirmation. Impact: Elucidating the role of hormones in brain tumor development has important implications and needs to be further examined using biological measurements. Cancer Epidemiol Biomarkers Prev; 19(10); 2562-9. (C) 2010 AACR.
- Published
- 2010
47. Coffee and tea intake and risk of brain tumors in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort study
- Author
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Michaud, Dominique S. Gallo, Valentina Schlehofer, Brigitte and Tjonneland, Anne Olsen, Anja Overvad, Kim Dahm, Christina C. and Teucher, Birgit Lukanova, Annekatrin Boeing, Heiner and Schutze, Madlen Trichopoulou, Antonia Lagiou, Pagona and Kyrozis, Andreas Sacerdote, Carlotta Krogh, Vittorio Masala, Giovanna Tumino, Rosario Mattiello, Amalia de Mesquita, H. Bas Bueno Ros, Martine M. Peeters, Petra H. M. van Gils, Carla H. Skeie, Guri Engeset, Dagrun Parr, Christine L. and Ardanaz, Eva Chirlaque, Maria-Dolores Dorronsoto, Miren Jose Sanchez, Maria Arguelles, Marcial Jakszyn, Paula Nilsson, Lena M. Melin, Beatrice S. Manjer, Jonas Wirfalt, Elisabet and Khaw, Kay-Tee Wareham, Nick Allen, Naomi E. Key, Timothy J. Romieu, Isabelle Vinets, Paolo Riboli, Elio
- Abstract
Background In a recent US cohort study total coffee and tea consumption was inversely associated with risk of glioma and ex penmental studies showed that caffeine can slow the invasive growth of glioblastoma Objective The objective was to examine the relation between coffee and tea Intake and the risk of glioma and meningioma in a large European cohort study the European Prospective Investigation into Cancer and Nutrition (EPIC) Design Data on coffee and tea intake were collected from men and women recruited Into the EPIC cohort study Over an average of 8 5 y of follow up 343 cases of glioma and 245 cases of meningioma were newly diagnosed in 9 countries We used Cox proportional hazards models to examine the relation between coffee and tea and brain tumors Results We observed no associations between coffee tea or corn billed coffee and tea consumption and risk of either type of brain tumor when using quantiles based on country-specific distributions of Intake However a significant inverse association was observed for glioma risk among those consuming >= 100 mL coffee and tea per day compared with those consuming
- Published
- 2010
48. Fruit, vegetables, and colorectal cancer risk: the European Prospective Investigation into Cancer and Nutrition
- Author
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van Duijnhoven, Fraenzel J. B. Bueno-De-Mesquita, H. Bas and Ferrari, Pietro Jenab, Mazda Boshuizen, Hendriek C. Ros, Martine M. Casagrande, Corinne Tjonneland, Anne Olsen, Anja and Overvad, Kim Thorlacius-Ussing, Ole Clavel-Chapelon, Francoise Boutron-Ruault, Marie-Christine Morois, Sophie and Kaaks, Rudolf Linseisen, Jakob Boeing, Heiner Noethlings, Ute Trichopoulou, Antonia Trichopoulos, Dimitrios Misirli, Gesthimani Palli, Domenico Sieri, Sabina Panico, Salvatore and Tumino, Rosario Vineis, Paolo Peeters, Petra H. M. van Gils, Carla H. Ocke, Marga C. Lund, Eiliv Engeset, Dagrun and Skeie, Guri Rodriguez Suarez, Laudina Gonzalez, Carlos A. and Sanchez, Maria-Jose Dorronsoro, Miren Navarro, Carmen and Barricarte, Aurelio Berglund, Goran Manjer, Jonas Hallmans, Goran Palmqvist, Richard Bingham, Sheila A. Khaw, Kay-Tee and Key, Timothy J. Allen, Naomi E. Boffetta, Paolo Slimani, Nadia Rinaldi, Sabina Gallo, Valentina Norat, Teresa and Riboli, Elio
- Abstract
Background: A high consumption of fruit and vegetables is possibly associated with a decreased risk of colorectal cancer (CRC). However, the findings to date are inconsistent. Objective: We examined the relation between self-reported usual consumption of fruit and vegetables and the incidence of CRC. Design: In the European Prospective Investigation into Cancer and Nutrition (EPIC), 452,755 subjects (131,985 men and 320,770 women) completed a dietary questionnaire in 1992-2000 and were followed up for cancer incidence and mortality until 2006. A multivariate Cox proportional hazard model was used to estimate adjusted hazard ratios (HRs) and 95% CIs. Results: After an average follow-up of 8.8 y, 2,819 incident CRC cases were reported. Consumption of fruit and vegetables was inversely associated with CRC in a comparison of the highest with the lowest EPIC-wide quintile of consumption (HR: 0.86; 95% CI: 0.75, 1.00; P for trend 0.04), particularly with colon cancer risk (HR: 0.76; 95% CI: 0.63, 0.91; P for trend < 0.01). Only after exclusion of the first 2 y of follow-up were these findings corroborated by calibrated continuous analyses for a 100-g increase in consumption: HRs of 0.95 (95% CI: 0.91, 1.00; P 0.04) and 0.94 (95% CI: 0.89, 0.99; P = 0.02), respectively. The association between fruit and vegetable consumption and CRC risk was inverse in never and former smokers, but positive in current smokers. This modifying effect was found for fruit and vegetables combined and for vegetables alone (P for interaction, 0.01 for both). Conclusions: These findings suggest that a high consumption of fruit and vegetables is associated with a reduced risk of CRC, especially of colon cancer. This effect may depend on smoking status. Am J Clin Nutr 2009;89:1441-52.
- Published
- 2009
49. Diabetes and the risk of non-Hodgkin's lymphoma and multiple myeloma in the European Prospective Investigation into Cancer and Nutrition
- Author
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Khan, Aneire E, Gallo, Valentina, Linseisen, Jakob, Kaaks, Rudolf, Rohrmann, Sabine, Raaschou-Nielsen, Ole, Tjønneland, Anne, Johnsen, Hans E, Overvad, Kim, Bergmann, Manuela M, Boeing, Heiner, Benetou, Vasiliki, Psaltopoulou, Theodora, Trichopoulou, Antonia, Masala, Giovanna, Mattiello, Amalia, Grioni, Sara, Tumino, Rosario, Vermeulen, Roel CH, Peeters, Petra HM, Bueno-de-Mesquita, H Bas, Ros, Martine M, Lund, Eiliv, Ardanaz, Eva, Chirlaque, María-Dolores, Jakszyn, Paula, Larrañaga, Nerea, Losada, Adamina, Becker, Nikolaus, Nieters, Alexandra, Martínez-García, Carmen, Agren, Asa, Hallmans, Göran, Berglund, Göran, Manjer, Jonas, Allen, Naomi E, Key, Timothy J, Bingham, Sheila, Khaw, Kay Tee, Slimani, Nadia, Ferrari, Pietro, Boffetta, Paolo, Norat, Teresa, Vineis, Paolo, Riboli, Elio, and EPIC Group
- Subjects
immune system diseases ,hemic and lymphatic diseases - Abstract
BACKGROUND: Non-Hodgkin's lymphomas are a heterogeneous group of neoplasms arising from the lymphopoietic system including a wide range of subtypes of either B-cell or T-cell lymphomas. The few established risk factors for the development of these neoplasms include viral infections and immunological abnormalities, but their etiology remains largely unknown. Evidence suggests that certain medical conditions may be linked, through immunosuppression, to the risk of non-Hodgkin's lymphoma. Multiple myeloma is a neoplasm of plasma cells that accounts for approximately 15% of lymphopoietic cancers. Increases in the incidence of non-Hodgkin's lymphoma and multiple myeloma in the past implicate environmental factors as potential causal agents. DESIGN AND METHODS: In the European Prospective Investigation into Cancer and Nutrition (EPIC), 1,213 histologically confirmed incident cases of non-Hodgkin's lymphoma and multiple myeloma (594 men; 619 women) were identified during a follow-up of 8.5 years. Cox proportional hazard models were used to explore the association between self-reported diabetes, diagnosed after 30 years of age, and the risk of non-Hodgkin's lymphoma overall and multiple myeloma and various lymphoma subtypes. RESULTS: We found no association between a personal history of diabetes and the risk of non-Hodgkin's lymphoma overall in men (HR: 1.28, 95% CI: 0.89-1.84), in women (HR: 0.71, 95% CI: 0.41- 1.24), or in men and women combined (HR: 1.09, 95% CI: 0.80-1.47). Among the B-non-Hodgkin's lymphoma subtypes, we observed a statistically significant increased risk of B-cell chronic lymphocytic leukemia (HR: 2.0, 95% CI: 1.04-3.86) in men, but not in women (HR: 1.07, 95% CI: 0.33-3.43). CONCLUSIONS: This prospective study did not provide evidence for a role of self-reported diabetes in the etiology of non-Hodgkin's lymphoma overall or multiple myeloma. We found an increased risk of B-cell chronic lymphocytic leukemia among men with diabetes, but not among women. We hypothesize that diabetes may not play a causal role in the etiology of B-cell chronic lymphocytic leukemia, though the underlying pathogenic mechanisms of both disorders may include shared genetic, host and/or environmental susceptibility factors.
- Published
- 2008
50. N-acetyltransferase 2 Phenotype, Occupation, and Bladder Cancer Risk : Results from the EPIC Cohort
- Author
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Pesch, Beate, Gawrych, Katarzyna, Rabstein, Sylvia, Weiss, Tobias, Casjens, Swaantje, Rihs, Hans-Peter, Ding, Hui, Angerer, Juergen, Illig, Thomas, Klopp, Norman, Bueno-de-Mesquita, Bas, Ros, Martine M., Kaaks, Rudolf, Chang-Claude, Jenny, Roswall, Nina, Tjonneland, Anne, Overvad, Kim, Clavel-Chapelon, Francoise, Boutron-Ruault, Marie-Christine, Dossus, Laure, Boeing, Heiner, Weikert, Steffen, Trichopoulos, Dimitrios, Palli, Domenico, Sieri, Sabina, Tumino, Rosario, Panico, Salvatore, Ramon Quiros, Jose, Gonzalez, Carlos, Jose Sanchez, Maria, Dorronsoro, Miren, Navarro, Carmen, Barricarte, Aurelio, Ljungberg, Börje, Johansson, Mattias, Ulmert, David, Ehrnstrom, Roy, Khaw, Kay-Tee, Wareham, Nick, Key, Timothy J., Ferrari, Pietro, Romieu, Isabelle, Riboli, Elio, Bruening, Thomas, Vineis, Paolo, Pesch, Beate, Gawrych, Katarzyna, Rabstein, Sylvia, Weiss, Tobias, Casjens, Swaantje, Rihs, Hans-Peter, Ding, Hui, Angerer, Juergen, Illig, Thomas, Klopp, Norman, Bueno-de-Mesquita, Bas, Ros, Martine M., Kaaks, Rudolf, Chang-Claude, Jenny, Roswall, Nina, Tjonneland, Anne, Overvad, Kim, Clavel-Chapelon, Francoise, Boutron-Ruault, Marie-Christine, Dossus, Laure, Boeing, Heiner, Weikert, Steffen, Trichopoulos, Dimitrios, Palli, Domenico, Sieri, Sabina, Tumino, Rosario, Panico, Salvatore, Ramon Quiros, Jose, Gonzalez, Carlos, Jose Sanchez, Maria, Dorronsoro, Miren, Navarro, Carmen, Barricarte, Aurelio, Ljungberg, Börje, Johansson, Mattias, Ulmert, David, Ehrnstrom, Roy, Khaw, Kay-Tee, Wareham, Nick, Key, Timothy J., Ferrari, Pietro, Romieu, Isabelle, Riboli, Elio, Bruening, Thomas, and Vineis, Paolo
- Abstract
Background: An association between N-acetyltransferase 2 (NAT2) slow acetylation and bladder cancer has been consistently observed in epidemiologic studies. However, evidence has been mainly derived from case-control studies and was sparse from cohort studies. We evaluated the association between NAT2 slow acetylation and bladder cancer in a case-control study nested in the European Prospective Investigation into Cancer and Nutrition. Methods: Exposure to aromatic amines and polycyclic aromatic hydrocarbons (PAH) could be assessed for 754 cases and 833 controls for whom occupational information was documented. A semiquantitative job-exposure matrix was applied to at-risk occupations to estimate the exposure as low, medium, or high based on tertiles of the distribution of the exposure score in controls. Using a comprehensive genotyping, NAT2 acetylation status could be categorized from 6-single-nucleotide polymorphism genotypes as slow or fast in 607 cases and 695 controls with DNA from archived blood samples. Results: Occupational exposure to aromatic amines and PAH was associated with an increased bladder cancer risk [upper tertile of the distribution of the exposure score: OR = 1.37; 95% confidence interval (CI), 1.02-1.84, and OR = 1.50; 95% CI, 1.09-2.05, respectively]. NAT2 slow acetylation did not modify these risk estimates and was not itself associated with bladder cancer risk (OR = 1.02; 95% CI, 0.81-1.29). Conclusions: These findings confirm established or suspected occupational risk factors but not the anticipated role of NAT2 slow acetylation in bladder cancer. No interaction was detected between NAT2 and any exposure of interest, including smoking. Impact: Genetic testing for NAT2 would be inappropriate in occupational settings.
- Published
- 2013
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