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1. Retinoblastoma with and without Extraocular Tumor Extension

Author

Swathi Kaliki, MD, Vijitha S. Vempuluru, MD, Ido Didi Fabian, MD, Elhassan Abdallah, MD, Shehu U. Abdullahi, MD, Rula A. Abdulqader, MD, Aminatu A. Abdulrahaman, MD, Sherif Abouelnaga, MD, Dupe S. Ademola-Popoola, FMCOph, FWACS, Adedayo Adio, FWACS, Mahmoud A. Afifi, MD, Armin R. Afshar, MD, Priyanka Aggarwal, MD, Ada E. Aghaji, FMCOph MSc, Alia Ahmad, MRCPCH UK, Marliyanti N.R. Akib, MD, Adeseye M. Akinsete, MBBS, Lamis Al Harby, MD, Saleh A. Al Mesfer, MD, Mouroge H. Al Ani, MD, Silvia Alarcón Portabella, MD, Safaa A.F. Al-Badri, MD, Ana Patricia A. Alcasabas, MD, Saad A. Al-Dahmash, MD, Amanda Alejos, MD, Ernesto Alemany-Rubio, MD, Amadou I. Alfa Bio, MD, Yvania Alfonso Carreras, MD, Christiane E. Al-Haddad, MD, Hamoud H.Y. Al-Hussaini, MD, MSc, Amany M. Ali, MD, Donjeta B. Alia, MD, Mazin F. Al-Jadiry, MD, Usama Al-Jumaly, MD, Hind M. Alkatan, MD, Charlotta All-Eriksson, MD, PhD, Ali A.R.M. Al-Mafrachi, FIBMS, Argentino A. Almeida, MD, Khalifa M. Alsawidi, MD, Athar A.S.M. Al-Shaheen, MD, Entissar H. Al-Shammary, MD, Doreen Amankwaa-Frempong, MBChB, Primawita O. Amiruddin, MD, Inggar Armytasari, MD, Nicholas J. Astbury, FRCS, FRCOphth, Hatice T. Atalay, MD, Eda Ataseven, MD, La-ongsri Atchaneeyasakul, MD, Rose Atsiaya, OCO, Rudolf Autrata, MD, PhD, Julia Balaguer, MD, PhD, Ruhengiz Balayeva, PhD, Honorio Barranco, MD, PhD, Paulina Bartoszek, MD, Katarina Bartuma, MD, PhD, Covadonga Bascaran, MD, MSc, Nikolaos E. Bechrakis, MD, Maja Beck Popovic, MD, Ainura S. Begimkulova, MD, Sarra Benmiloud, MD, Rokia C. Berete, MD, PhD, Jesse L. Berry, MD, Anirban Bhaduri, MD, Sunil Bhat, MBBS, MD, Arpita Bhattacharyya, MD, Eva M. Biewald, MD, Elaine Binkley, MD, Sharon Blum, MD, Nadia Bobrova, MD, H. Culver Boldt, MD, Maria Teresa B.C. Bonanomi, MD, PhD, Gabrielle C. Bouda, MD, Hédi Bouguila, MD, PhD, Rachel C. Brennan, MD, Bénédicte G. Brichard, MD, PhD, Jassada Buaboonnam, MD, Aléine Budiongo, MD, Matthew Burton, FRCOphth, Patricia Calderón-Sotelo, MD, Doris A. Calle Jara, MD, Jayne E. Camuglia, FRANZCO, Miriam R. Cano, MD, MSc, Michael Capra, FRCPI, Shani Caspi, MD, Nathalie Cassoux, MD, PhD, Guilherme Castela, MD, Luis Castillo, MD, Jaume Català-Mora, MD, PhD, Isabel Caviedes, MD, Arthika Chandramohan, MD, Guillermo L. Chantada, MD, PhD, Shabana Chaudhry, MD, Bhavna Chawla, MD, Wensi Chen, MD, Faraja S. Chiwanga, MSc, Tsengelmaa Chuluunbat, MD, PhD, Krzysztof Cieslik, MD, Antony Clark, FRANZCO, Ruellyn L. Cockcroft, MB ChB , M Med Paed, Codruta Comsa, MD, Maria G. Correa Llano, MD, Timothy W. Corson, PhD, Line Couitchere, MD, Kristin E. Cowan-Lyn, MD, MBBS, Monika Csóka, MD, PhD, Wantanee Dangboon, MD, Anirban Das, MD, Pranab Das, MD, Sima Das, MS, Jacquelyn M. Davanzo, BSN, BSPH, Alan Davidson, MBChB, MPhil, Sonia De Francesco, MD, Patrick De Potter, MD, PhD, Karina Q. Delgado, MD, PhD, Hakan Demirci, MD, Laurence Desjardins, MD, Rosdali Y. Diaz Coronado, MD, Helen Dimaras, PhD, Andrew J. Dodgshun, M Phil, Carla R. Donato Macedo, MD, Monica D. Dragomir, MD, PhD, Yi Du, MD, Magritha Du Bruyn, MD, Johannes P. Du Plessis, MMed (Paed), Gagan Dudeja, MBBS, MS, Katrin Eerme, MD, I Wayan Eka Sutyawan, MD, Asmaa El Kettani, MD, Amal M. Elbahi, MD, James E. Elder, MBBS, Alaa M. Elhaddad, MD, PhD, Moawia M.A. Elhassan, MD, Mahmoud M. Elzembely, MD, Connor Ericksen, MD, Vera A. Essuman, FWACS, Ted Grimbert A. Evina, MD, Ifeoma R. Ezegwui, FMCOph, FWACS, FAEH, Zehra Fadoo, MBBS, Adriana C. Fandiño, MD, Mohammad Faranoush, MD, Oluyemi Fasina, FWACS, Delia D.P.G. Fernández, MSc, Ana Fernández-Teijeiro, MD, PhD, Allen Foster, FRCOphth, Shahar Frenkel, MD, PhD, Ligia D. Fu, MD, Soad L. Fuentes-Alabi, MD, MPH, Juan L. Garcia, MSc, David García Aldana, MD, Henry N. Garcia Pacheco, MD, Jennifer A. Geel, MBChB, MMed, Fariba Ghassemi, MD, Ana V. Girón, MD, Marco A. Goenz, MD, Aaron S. Gold, OD, Hila Golberg, MD, Glen A. Gole, MD, FRANZCO, Nir Gomel, MD, Efren Gonzalez, MD, Graciela Gonzalez Perez, MD, Liudmira González-Rodríguez, MD, Malka Gorfine, PhD, Jaime Graells, MD, Pernille A. Gregersen, MD, Nathalia D.A.K. Grigorovski, MD, Koffi M. Guedenon, MD, D Sanjeeva Gunasekera, MD, Ahmet K. Gündüz, MD, Himika Gupta, MD, Sanjiv Gupta, MS, Vineeta Gupta, MD, Theodora Hadjistilianou, MD, Patrick Hamel, MD, Syed A. Hamid, FCPS, Norhafizah Hamzah, MSc, Eric D. Hansen, MD, J William Harbour, MD, M. Elizabeth Hartnett, MD, Murat Hasanreisoglu, MD, Sadiq Hassan, MD, FWACS, Shadab Hassan, FRCS, FCPS, Wojciech Hautz, MD, Huda A. Haydar, CHD, Stanislava Hederova, MD, Laila Hessissen, MD, Hoby Lalaina, MD, Suradej Hongeng, MD, Diriba F. Hordofa, MD, G. Baker Hubbard, MD, Marlies Hummlen, MD, Kristina Husakova, MD, Allawi N. Hussein Al-Janabi, MD, Affiong A. Ibanga, MB.BCh, FMCOph, Russo Ida, MD, Vesna R. Ilic, MD, Ziyavuddin Islamov, MD, Vivekaraj Jairaj, DNB, Teyyeb A. Janjua, MD, FCPS, FRCSEd, Irfan Jeeva, FRCOphth, Xunda Ji, MD, Dong Hyun Jo, MD, PhD, Michael M. Jones, MD, PhD, FRANZCO, Theophile B. Amani Kabesha, MD, PhD, Rolande L. Kabore, MD, Abubakar Kalinaki, MD, Pius Kamsang, MD, Mehmet Kantar, MD, Noa Kapelushnik, MD, Tamar Kardava, PhD, Rejin Kebudi, MD, Jonny Keomisy, MD, Tomas Kepak, MD, Petra Ketteler, MD, Zohora J. Khan, MD, Hussain A. Khaqan, MD, Vikas Khetan, FRCS, FACS, Alireza Khodabande, MD, Zaza Khotenashvili, MD, Jonathan W. Kim, MD, Jeong Hun Kim, MD, PhD, Hayyam Kiratli, MD, Tero T. Kivelä, MD, Artur Klett, MD, PhD, Irem Koç, MD, Jess Elio Kosh Komba Palet, MD, Dalia Krivaitiene, MD, PhD, Mariana Kruger, Mmed Paed, PhD, Kittisak Kulvichit, MD, Mayasari W. Kuntorini, MD, Alice Kyara, BA, Geoffrey C. Lam, FRANZCO, Scott A. Larson, MD, Slobodanka Latinović, MD, PhD, Kelly D. Laurenti, MD, Yotam Lavi, MD, PhD, Alenka Lavric Groznik, MD, Amy A. Leverant, MD, Cairui Li, MD, Kaijun Li, MD, Ben Limbu, MD, Chun-Hsiu Liu, MD, Quah Boon Long, FRCS (Ed), MMed ( Ophth), FAMS, Juan P. López, MD, Robert M. Lukamba, MD, Sandra Luna-Fineman, MD, Delfitri Lutfi, MD, Lesia Lysytsia, MD, Shiran Madgar, MD, George N. Magrath, MD, Amita Mahajan, MD, Puja Maitra, MD, Erika Maka, MD, Emil K. Makimbetov, MD, Azza M.Y. Maktabi, MD, Carlos Maldonado, MD, Ashwin Mallipatna, MD, Rebecca Manudhane, MD, Lyazat Manzhuova, MD, Nieves Martín Begue, MD, PhD, Sidra Masud, MBBS, Ibrahim O. Matende, MD, M. Med (Oph), Clarissa C.D.S. Mattosinho, MD, Marchelo Matua, BAPH, Ismail Mayet, MD, Freddy B. Mbumba, MD, MMed Paed, John D. McKenzie, MD, Azim Mehrvar, MD, Aemero A. Mengesha, MD, Vikas Menon, MD, Gary John V.D.D. Mercado, MD, Marilyn B. Mets, MD, Edoardo Midena, MD, PhD, Audra Miller, MD, Divyansh K.C. Mishra, DNB, Furahini G. Mndeme, MD, Ahmed A. Mohamedani, FRCPath, Mona T. Mohammad, MD, FRCS, Annette C. Moll, MD, PhD, Margarita M. Montero, MD, Claude Moreira, MD, PhD, Prithvi Mruthyunjaya, MD, MHS, Mchikirwa S. Msina, MMed Ophth, Gerald Msukwa, MMed Ophth, Sangeeta S. Mudaliar, DNB Pediatric, Hassan Muhammad, MD, Kangwa I. Muma, MMed Ophth, FCOphth, Francis L. Munier, MD, Timothy G. Murray, MD, MBA, Kareem O. Musa, FWACS, FMCOphth, FICO, Asma Mushtaq, MD, Anne A. Musika, MD, Hamzah Mustak, MD, Tajudeen Mustapha, MBBS, FWACS, Okwen M. Muyen, MD, Khumo H. Myezo, Msc, Gita Naidu, MMed Paed, PhD, Natasha Naidu, MBCHB, FCS Ophthalmol, Akshay Gopinathan Nair, MD, Sundaram Natarajan, FRCS, Larisa Naumenko, MD, PhD, Paule Aïda Ndoye Roth, MD PhD, Yetty M. Nency, MD, Vladimir Neroev, MD, PhD, Yvonne Ng, MBChB ( Auckland) , FRANZCO, Marina Nikitovic, MD, PhD, Elizabeth D. Nkanga, FMCOph, Henry E. Nkumbe, MD, Marcel N. Numbi, MD, Kalle Nummi, MD, Murtuza Nuruddin, FRCS, Mutale Nyaywa, MD, MMed Ophth, FCOphth, Chinsisi Nyirenda, MD, Ghislaine Obono-Obiang, MD, Scott C.N. Oliver, MD, Joaquin Ooporto, MD, Miriam Ortega-Hernández, MD, Alexander Oscar, MD, Diego Ossandon, MD, Halimah Pagarra, MD, PhD, Vivian Paintsil, FWACP, Luisa Paiva, MD, Mahesh Shanmugam Palanivelu, FRCSED, Ruzanna Papyan, MD, Raffaele Parrozzani, MD, PhD, Claudia R. Pascual Morales, MD, Katherine E. Paton, MD, FRCSC, Jacob Pe'er, MD, Jesús Peralta Calvo, MD, Sanja Perić, MD, PhD, Chau T.M. Pham, MD, Remezo Philbert, MD, David A. Plager, MD, Pavel Pochop, MD, PhD, Rodrigo A. Polania, MD, Vladimir Polyakov, MD, Jimena Ponce, MD, Ali O. Qadir, MD, Seema Qayyum, FCPS, Jiang Qian, MD, Ardizal Rahman, MD, Purnima Rajkarnikar, MD, Rajesh Ramanjulu, MD, Aparna Ramasubramanian, MD, Marco A. Ramirez-Ortiz, MD, MPH, Jasmeen K. Randhawa, BA, Léa Raobela, MD, Riffat Rashid, MS, M. Ashwin Reddy, FRCOphth, Lorna A. Renner, FRCPCH (UK), David Reynders, MD, Dahiru Ribadu, FMCOph, Petra Ritter-Sovinz, MD, Anna Rogowska, MD, Duangnate Rojanaporn, MD, Livia Romero, MD, Soma R. Roy, DCO, Raya H. Saab, MD, Svetlana Saakyan, MD, PhD, Ahmed H. Sabhan, MD, Mandeep S. Sagoo, FRCS (Ed), Azza M.A. Said, MD, Rohit Saiju, MD, Beatriz Salas, MD, Sonsoles San Román Pacheco, MD, Gissela L. Sánchez, MD, Alma Janeth Sanchez Orozco, MD, Phayvanh Sayalith, MD, Trish A. Scanlan, MRCPI, MSc, Christoph Schwab, MD, Ahad Sedaghat, MD, Rachna Seth, DNB MNAMS, Mariana Sgroi, MD, Ankoor S. Shah, MD, PhD, Shawkat A. Shakoor, MS, Manoj K. Sharma, MD, Sadik T. Sherief, MD, Carol L. Shields, MD, David Sia, MB ChB, FRANZCO, Sorath Noorani Siddiqui, MD, Sidi Sidi cheikh, MD, PhD, Sónia Silva, MD, Arun D. Singh, MD, Usha Singh, MS, Penny Singha, MD, Rita S. Sitorus, MD, PhD, Alison H. Skalet, MD, PhD, Hendrian D. Soebagjo, MD, PhD, Tetyana Sorochynska, MD, PhD, Grace Ssali, MD, Andrew W. Stacey, MD, Sandra E. Staffieri, PhD, Erin D. Stahl, MD, David M. Steinberg, PhD, David K. Stones, MBChB, FCPaed, Caron Strahlendorf, MD, Maria Estela Coleoni Suarez, MD, Sadia Sultana, FCPS, Xiantao Sun, MD, Rosanne Superstein, MD, Eddy Supriyadi, MD, PhD, Supawan Surukrattanaskul, MD, Shigenobu Suzuki, MD, PhD, Karel Svojgr, MD, PhD, Fatoumata Sylla, MD, Gevorg Tamamyan, MD, PhD, Deborah Tan, MBBS, Alketa Tandili, MD, PhD, Jing Tang, MD, Fanny F. Tarrillo Leiva, MD, Maryam Tashvighi, MD, Bekim Tateshi, MD, PhD, Kok Hoi Teh, MD, Edi S. Tehuteru, MD, Luiz F. Teixeira, MD, Manca Tekavcic Pompe, MD, PhD, Abdullah Dahan M. Thawaba, MD, Tuyisabe Theophile, MSc, Helen Toledano, MBChB, Doan L. Trang, MD, Fousseyni Traoré, MD, Devjyoti Tripathy, MD, Samuray Tuncer, MD, Harba Tyau-Tyau, MD, Ali B. Umar, MD, FMCPath, Emel Unal, MD, Ogul E. Uner, BA, Steen F. Urbak, MD, PhD, Tatiana L. Ushakova, MD, Rustam H. Usmanov, MD, Sandra Valeina, MD, Paola Valente, MD, Milo van Hoefen Wijsard, MD, Jacqueline Karina Vasquez Anchaya, MD, Leon O. Vaughan, FRCS (Ed), Nevyana V. Veleva-Krasteva, MD, PhD, Nishant Verma, MD, Andi A. Victor, MD, PhD, Maris Viksnins, MD, Edwin G. Villacís Chafla, MD, Victor M. Villegas, MD, Victoria Vishnevskia-Dai, MD, Keith Waddell, DM, FRCP, FRCS, FRCOphth, Amina H. Wali, MD, FMCOph Nigeria, Yi-Zhuo Wang, MD, Nutsuchar Wangtiraumnuay, MD, FICO, Julie A. Wetter, MMed Rad Onc, FCRad Onc, Widiarti P. Riono, MD, Matthew W. Wilson, MD, Amelia D.C. Wime, MD, Atchareeya Wiwatwongwana, MD, Damrong Wiwatwongwana, MD, Charlotte Wolley Dod, MD, Emily S. Wong, FCOphth HK, FHKAM, Phanthipha Wongwai, MD, PhD, Si-qi Wu, MSc, Daoman Xiang, MD, PhD, Yishuang Xiao, MSc, Bing Xu, MD, Kang Xue, MD, Antonio Yaghy, MD, Jason C. Yam, FRCSEd, Huasheng Yang, MD, Jenny M. Yanga, MD, Muhammad A. Yaqub, MD, FCPS, FRCSEd, Vera A. Yarovaya, MD, Andrey A. Yarovoy, MD, PhD, Huijing Ye, MD, Roberto I. Yee, MD, Yacoub A. Yousef, MD, Putu Yuliawati, MD, Arturo M. López, MD, Ekhtelbenina Zein, MD, Yi Zhang, MD, PhD, Katsiaryna Zhilyaeva, MD, Nida Zia, MBBS, MCPS, Othman A.O. Ziko, MD, PhD, Marcia Zondervan, MBA, Sabrina Schlüter, MD, and Richard Bowman, FRCOphth

Subjects
External beam radiotherapy, Extraocular extension, Multimodal treatment, Retinoblastoma, Tumor, Ophthalmology, RE1-994
Abstract

Purpose: To study the treatment and outcomes of children with retinoblastoma (RB) with extraocular tumor extension (RB-EOE) and compare them with RB without extraocular tumor extension (RB-w/o-EOE). Design: Multicenter intercontinental collaborative prospective study from 2017 to 2020. RB-EOE cases included those with overt orbital tumor extension in treatment-naive patients. Cases with microscopic orbital extension detected postenucleation were excluded from the study. Participants: A total of 319 children with RB-EOE and 3116 children with RB-w/o-EOE. Intervention: Chemotherapy, enucleation, exenteration, radiotherapy. Main Outcome Measures: Systemic metastasis and death. Results: Of the 3435 RB patients included in this study, 309 (9%) were from low-income countries (LIC), 1448 (42%) from lower-middle income, 1012 (29%) from upper-middle income, and 666 (19%) patients from high-income countries. There was an inverse relationship between the percentage of RB-EOE and national income level, with 96 (31%) patients from LIC, 197 (6%) lower-middle income, 20 (2%) upper-middle income, and 6 (1%) patients from high-income countries (P = 0.0001). The outcomes were statistically significant for RB-EOE compared with RB-w/o-EOE: systemic metastasis (32% vs. 4% respectively; P = 0.0001) and metastasis-related death (63% vs. 6% respectively; P = 0.0001). Multimodal treatment was the most common form of treatment (n = 177; 54%) for RB-EOE, with most cases undergoing a combination of intravenous chemotherapy and enucleation (n = 97; 30%). Adjuvant external beam radiotherapy (EBRT) after surgery (enucleation/orbital exenteration) was given in only 68 (21%) cases. Kaplan–Meier analysis for systemic metastasis and metastasis-related death in RB-EOE was 28% and 57% at 1 year, 29% and 60% at 2 years, and 29% and 61% at 3 years, respectively. Cox regression analysis revealed that the risk of death from RB-EOE was greater in patients aged >4 years than

Published
2025
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2. Anti-proliferative and anti-tumour effects of lymphocyte-derived microparticles are neither species- nor tumour-type specific

Author

Chun Yang, Wei Xiong, Qian Qiu, Houda Tahiri, Rosanne Superstein, Anne-Sophie Carret, Przemyslaw Sapieha, and Pierre Hardy

Subjects
microparticles, lymphocytes, tumour growth, anti-proliferation, cell cycle, Cytology, QH573-671
Abstract

Background: Unregulated cell proliferation or growth is a prominent characteristic of cancer. We have previously demonstrated that LMPs (cell membrane microparticles derived from apoptotic human CEM T lymphoma cells stimulated with actinomycin D) strongly suppress the proliferation of not only human endothelial cells but also mouse Lewis lung carcinoma cells. Methods: LMPs were generated either from CEM T cells using different stimuli or from 3 different types of lymphocytes. The effects of LMPs on cancer cell proliferation were examined using cell lines from different species and tissues. The cell cycle kinetics was evaluated by FACS and the expression of cell cycle-related genes was determined using quantitative RT-PCR. The in vivo anti-tumor effect of LMPs was investigated using xenografts and allografts. Results: LMPs at doses far above physiological levels dramatically suppressed the proliferation of cancer cells in a non species-specific manner. LMPs selectively target high proliferating cells and their anti-proliferative effect is not dependent on parental cell origin or stimuli. The anti-proliferative effect of LMPs was due to induction of cell-cycle arrest in G0/G1, with associated increases in expression of the cyclin-dependent kinase inhibitors p15INK4b, p16INK4a, and p21Cip1. In vivo, LMPs significantly suppressed tumor growth in animal tumor models. Conclusion: These results highlight the potential role of LMPs in modulating the growth of high proliferating cells. Given that cell-based therapies are considered less toxic than pharmacologic approaches and have the potential to target multiple pathways in a synergistic manner, LMPs may serve as a veritable option for cancer treatment.

Published
2014
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3. The Pediatric Optic Neuritis Prospective Outcomes Study

Author

Stacy L. Pineles, Robert J. Henderson, Michael X. Repka, Gena Heidary, Grant T. Liu, Amy T. Waldman, Mark S. Borchert, Sangeeta Khanna, Jennifer S. Graves, Janine E. Collinge, Julie A. Conley, Patricia L. Davis, Raymond T. Kraker, Susan A. Cotter, Jonathan M. Holmes, Melinda Y. Chang, Dilshad Contractor, Emily J. Zolfaghari, Aarti Vyas, Tiffany Yuen, Veeral S. Shah, Evelyn A. Paysse, Gihan Romany, Jason H. Peragallo, Judy L. Brower, Aparna Raghuram, Bilal Al Wattar, Ryan Chinn, Srishti Kothari, R. Michael Siatkowski, Maria E. Lim, Alisha N. Brewer, Annette M. Doughty, Sonny W. Icks, Shannon Almeida, Alejandra de Alba Campomanes, Premilla Banwait, Leila Hajkazemshirazi, Yizhuo Bastea-Forte, Jennifer K. Arjona, Jeremy Chen, Karen Cooper, Rafif Ghadban, Sophia M. Chung, Oscar A. Cruz, Traci A. Christenson, Lisa L. Breeding, Dawn M. Govreau, Beth A. Wallis, Brooke E. Geddie, Elisabeth T. Wolinski, Indre M. Rudaitis, Jacqueline Twite, Carrie S. Bloomquist, Sarah R. Laboy, Jackie M. Twite, Michelle V. Doan, Marianne J. Bernardo, Michael C. Brodsky, John J. Chen, Suzanne M. Wernimont, Lindsay L. Czaplewski, Stacy L. Eastman, Moriah A. Keehn, Debbie M. Priebe, Don L. Bremer, Richard P. Golden, Catherine O. Jordan, Mary Lou McGregor, Rachel E. Reem, David L. Rogers, Amanda N. Schreckengost, Sara A. Maletic, Mays A. Dairi, Laura B. Enyedi, Sarah K. Jones, Navajyoti R. Barman, Robert J. House, David A. Nasrazadani, Sean M. Gratton, Justin D. Marsh, Rebecca J. Dent, Lezlie L. Bond, Lori L. Soske, Padmaja Sudhakar, Christi M. Willen, Deborah Taylor, Nathaniel Q. Moliterno, Michael Nsoesie, Shaista Vally, Paul H. Phillips, Robert S. Lowery, Beth Colon, Nancy L. Stotts, Kelly D. To, Collin M. McClelland, Raymond G. Areaux, Ann M. Holleschau, Kim S. Merrill, Luis H. Ospina, Rosanne Superstein, Maryse Thibeault, Helene Gagnon, Sean P. Donahue, Scott T. Ruark, Lisa A. Fraine, Petrice A. Sprouse, Ronald J. Biernacki, Robert A. Avery, Brian J. Forbes, Imran Jivraj, Anita A. Kohli, Meg M. Richter, Agnieshka Baumritter, Ellen B. Mitchell, Ken K. Nischal, Lauren M. Runkel, Bianca Blaha, Whitney Churchfield, Christina Fulwylie, Melissa W. Ko, Luis J. Mejico, Muhammad Iqbal, Catherine E. Attanasio, Lena F. Deb, Courtney B. Goodrich, Alisha M. Hartwell, Jennifer A. Moore, Lisa Bohra, Alexandra O. Apkarian, Elena M. Gianfermi, John D. Roarty, Leemor B. Rotberg, Susan N. Perzyk, Roy W. Beck, Darrell S. Austin, Nicole M. Boyle, Danielle L. Chandler, Patricia L. Connelly, Courtney L. Conner, Trevano W. Dean, Quayleen Donahue, Brooke P. Fimbel, Amra Hercinovic, James E. Hoepner, Joseph D. Kaplon, Zhuokai Li, Gillaine Ortiz, Julianne L. Robinson, Kathleen M. Stutz, David O. Toro, Victoria C. Woodard, Rui Wu, Laura Balcer, Mark Kupersmith, Elizabeth L. Lazar, Amy Waldman, David K. Wallace, Eileen E. Birch, Angela M. Chen, Stephen P. Christiansen, S. Ayse Erzurum, Donald F. Everett, Sharon F. Freedman, William V. Good, Katherine A. Lee, Richard London, Vivian M. Manh, Ruth E. Manny, David G. Morrison, Bonita R. Schweinler, Jayne L. Silver, Lisa C. Verderber, Katherine K. Weise, Ari Green, Marie Diener-West, John D. Baker, Barry Davis, Dale L. Phelps, Stephen W. Poff, Richard A. Saunders, and Lawrence Tychsen

Subjects
Ophthalmology
Published
2022
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4. Long-term outcomes of type 1 retinopathy of prematurity following monotherapy with bevacizumab: a Canadian experience

Author

Maram Isaac, Kamiar Mireskandari, Nicole Fallaha, Luis H. Ospina, Eileen Javidi, Sarah Chorfi, Rosanne Superstein, Patrick Hamel, and Nasrin N. Tehrani

Subjects
Ophthalmology, General Medicine
Abstract

To report long-term structural, visual, and refractive outcomes after monotherapy with intravitreal bevacizumab injection.Cohort retrospective chart review.A total of 56 premature infants with type 1 retinopathy of prematurity.This is a chart review at 2 Canadian institutions. Inclusion criteria were single injection of 0.625 mg intravitreal bevacizumab and minimum age at last follow-up of 3 years. Primary outcome was retinal structure. Secondary outcomes were refractive error in spherical equivalent, monocular visual acuity, strabismus, and amblyopia.Fifty-six infants (101 eyes) met inclusion criteria. Mean birth weight was 707 ± 178 g (range, 420-1520 g). Mean gestational age was 25.0 ± 1.3 weeks (range, 22.9-29.7 weeks). Twenty-four eyes were in zone I (24%) and 77 in zone II (76%). Mean postmenstrual age at treatment was 36.9 ± 2.1 weeks (range, 32.8-42.0 weeks). At a mean age of 5.4 ± 1.6 years (range, 3.0-8.0 years), all eyes had a favourable structural outcome with no reactivation requiring treatment. Mean monocular visual acuity was 0.29 ± 0.27 logMAR (range, 0.0-1.3 logMAR; 89 of 101 eyes). Mean spherical equivalent was -1.98 ± 4.91 D (range, -16.63 to +5.38 D; 101 of 101 eyes). Prevalence of emmetropia (-1.0 to ≤1 D) was 43.6%; low myopia (≥1.0 to5 D) was 17.8%; high myopia (≥5 to8 D) was 8.9 %; very high myopia (≥8.0 D) was 12.9%; and hyperopia (1 D) was 16.8%. Twelve children (23%) had amblyopia, and 17 (32%) developed strabismus.All patients demonstrated a favourable structural outcome with a single bevacizumab injection without the need for additional laser. We suggest regular monitoring following regression of acute retinopathy of prematurity as an alternative to universal, preplanned delayed prophylactic laser treatment. Future studies to evaluate other aspects of visual function are needed.

Published
2022
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5. Three‐year observation of children 12 to 35 months old with untreated intermittent exotropia

Author

Jonathan M. Holmes, Raymond T. Kraker, B. Michele Melia, Danielle L. Chandler, Eric R. Crouch, Brian G. Mohney, Evelyn A. Paysse, Rosanne Superstein, Susan A. Cotter, David K. Wallace, and Rui Wu

Subjects
Male, Pediatrics, medicine.medical_specialty, Time Factors, medicine.medical_treatment, Visual Acuity, Article, Occlusion, medicine, Humans, Strabismus, Vision, Binocular, business.industry, Clinical course, Infant, medicine.disease, Sensory Systems, Confidence interval, Ophthalmology, Child, Preschool, Chronic Disease, Disease Progression, Exotropia, Female, business, Motor deterioration, Intermittent exotropia, Watchful waiting, Follow-Up Studies, Optometry
Abstract

PURPOSE: To describe the clinical course of untreated intermittent exotropia (IXT) in children 12 to 35 months of age followed for three years. METHODS: We enrolled 97 children 12 to 35 months of age with previously untreated IXT who had been randomly assigned to the observation arm of a randomised trial of short-term occlusion versus observation. Participants were observed unless deterioration criteria were met at a follow-up visit occurring at 3 months, 6 months, and 6-month intervals thereafter for three years. The primary outcome was deterioration of the IXT by three years, defined as (1) a constant exotropia ≥10 prism dioptres (∆) at distance and near (i.e., motor deterioration) or (2) treatment prescribed despite not having met motor deterioration. The primary analysis used the Kaplan-Meier method to determine the cumulative proportion of participants meeting deterioration by three years and 95% confidence interval (CI). RESULTS: The cumulative probability of deterioration by three years was 28% (95% CI = 20% to 39%). Of the 24 participants meeting the primary outcome of deterioration, seven met motor deterioration and 17 were prescribed treatment without meeting motor deterioration. The cumulative probability of motor deterioration by three years was 10% (95% CI = 5% to 19%). CONCLUSIONS: Given the modest rate of motor deterioration over three years, watchful waiting may be a reasonable management approach in 12- to 35-month-old children with IXT. To confirm this recommendation would require a long-term randomised trial of immediate treatment versus observation followed by deferred treatment if needed.

Published
2020
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6. Pediatric ocular injuries: a 3-year review of patients presenting to an emergency department in Canada

Author

Caroline Bélanger, Caroline Gabias, Rosanne Superstein, Nicole Fallaha, and Cyril Archambault

Subjects
Male, Canada, Pediatrics, medicine.medical_specialty, Visual acuity, Adolescent, Population, Visual Acuity, MEDLINE, Eye Injuries, Age groups, medicine, Humans, Child, education, Retrospective Studies, education.field_of_study, business.industry, Incidence, Incidence (epidemiology), Retrospective cohort study, General Medicine, Emergency department, Ophthalmology, Child, Preschool, Female, medicine.symptom, Presentation (obstetrics), Emergency Service, Hospital, business, Follow-Up Studies
Abstract

Background Ocular traumas represent the most common cause of noncongenital blindness in children. Sports are the second most common cause in children less than 14 years old in Canada. To our knowledge, there have not yet been any reports regarding the causes of pediatric ocular trauma in the Quebec population. The goal of our study was to gather data from the Quebec pediatric population to determine high-risk age groups, sports, or other activities. Methods A retrospective study evaluating all patients younger than 18 years who presented with ocular trauma to the Ste-Justine Hospital emergency department between 2007 and 2010. Data obtained included age, sex, activity at the time of injury, mechanism of injury, and visual outcomes. Results Trauma was more common in males (65%). The mean age was 7.2 years. Injuries occurred more often in the 5–9 year age group, at home, and during free play. Sports-related injuries occurred more often in the 10–18 year age group, with hockey being associated most often with injuries. Visual acuity at presentation was variable, but final acuity was 20/30 or better in 86.7% of cases. In 89% of cases, there was no mention of ocular protection and prevention of injuries in the chart by emergency physicians. Conclusion Our study suggests that ocular injuries may be prevented by better supervision and parental education in the younger population and by mandating ocular protection for sports in high school–aged patients.

Published
2019
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8. Pediatric Ocular Injuries: A 3-Year Follow-up Study of Patients Presenting to a Tertiary Care Clinic in Canada

Author

Patrick Hamel, Cyril Archambault, Assia Mekliche, Jordan Isenberg, Rosanne Superstein, and Nicole Fallaha

Subjects
Male, Pediatrics, medicine.medical_specialty, Canada, Visual acuity, Time Factors, MEDLINE, Visual Acuity, Tertiary care, Tertiary Care Centers, 03 medical and health sciences, Ice hockey, 0302 clinical medicine, Eye Injuries, Risk Factors, 030225 pediatrics, medicine, Electronic Health Records, Humans, Strabismus, Child, Retrospective Studies, business.industry, Incidence, Follow up studies, Electronic medical record, Infant, Newborn, Infant, General Medicine, Ophthalmology, Child, Preschool, Pediatrics, Perinatology and Child Health, Cohort, 030221 ophthalmology & optometry, Female, Seasons, medicine.symptom, business, human activities, Follow-Up Studies
Abstract

Purpose: To identify age groups or activities at risk for ocular injuries to provide parents, sports teams, schools, and hospitals with the appropriate tools for prevention strategies. Methods: A retrospective chart review was conducted of all trauma-related cases from 2013 to 2015 and data were obtained with the use of an electronic medical record. All patients younger than 18 years who presented to the ophthalmology clinic with traumatic ocular injuries were included. Results: A total of 409 patients met the inclusion criteria and all were included in this study. The mean age was 7.74 years. Boys were injured more frequently than girls (60.4%). Most ocular injuries occurred between the ages of 2 and 9 years (51.8%). The most common sport was soccer, followed by ball/ice hockey, which differs from previous study findings. This may highlight the increasing popularity of soccer and the risk it may entail. Injuries occurred at home in 23.2% of cases. Final visual acuity was 20/40 or better in 77% of patients. Conclusions: These findings are comparable to the authors' previous data and to those of the only other Canadian study done on this subject, with the exception of an increased incidence of soccer-related injuries in the current cohort, highlighting an area important to future prevention strategies. [ J Pediatr Ophthalmol Strabismus . 2020;57(3):185–189.]

Published
2019

9. Co-delivery of miR-181a and melphalan by lipid nanoparticles for treatment of seeded retinoblastoma

Author

Rabeb Mouna Derbali, Pierre Hardy, Chun Yang, Patrick Hamel, Seyed Nasrollah Tabatabaei, Jeanne Leblond Chain, Rosanne Superstein, Université de Montréal (UdeM), and Université de Montréal [Montréal]

Subjects
Melphalan, Male, [SDV.BIO]Life Sciences [q-bio]/Biotechnology, Retinal Neoplasms, Cell, Pharmaceutical Science, Apoptosis, 02 engineering and technology, Rats, Sprague-Dawley, 03 medical and health sciences, [SDV.SP.MED]Life Sciences [q-bio]/Pharmaceutical sciences/Medication, Cell Line, Tumor, microRNA, medicine, Cytotoxic T cell, Animals, Humans, [CHIM]Chemical Sciences, Antineoplastic Agents, Alkylating, 030304 developmental biology, Cell Proliferation, 0303 health sciences, Liposome, Retinoblastoma, Chemistry, [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences, 021001 nanoscience & nanotechnology, medicine.disease, Lipids, Xenograft Model Antitumor Assays, 3. Good health, Rats, Gene Expression Regulation, Neoplastic, MicroRNAs, medicine.anatomical_structure, [SDV.SP.PG]Life Sciences [q-bio]/Pharmaceutical sciences/Galenic pharmacology, Cell culture, Cancer research, Nanoparticles, 0210 nano-technology, medicine.drug
Abstract

International audience; Melphalan is an efficient chemotherapeutic agent that is currently used to treat retinoblastoma (Rb); however, the inherent risk of immunogenicity and the hazardous integration of this drug in healthy cells is inevitable. MicroRNAs are short non-coding single-stranded RNAs that affect a vast range of biological processes. Previously, we focused on the regulatory role of miR-181a during cancer development and progression. In this manuscript, 171 nm switchable lipid nanoparticles (LNP) co-delivered melphalan and miR-181a with en-capsulation efficiencies of 93%. Encapsulation of melphalan in LNP significantly improved its therapeutic efficiency. Gene analysis shows that miR-181a decreases the expression of anti-proliferative gene MAPK1 and anti-apoptotic gene Bcl-2, but significantly increased the expression of pro-apoptotic gene BAX. Our results suggest that the two agents have a complementary effect in reducing the viability of cultured Rb cells (primary and cell line) and decreasing Rb cell counts in an in-vivo xenograft Rb model in rats. Our results suggest that the proposed co-delivery technique significantly increases the therapeutic impact, allows for lower administration of melphalan, and consequently, could minimize the cytotoxic side-effects of this drug.

Published
2019
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10. Adjustable surgical treatment of adult exotropia: postoperative target angles and surgical success

Author

Emmanuelle Chalifoux, Shamim Sabzevari, Rosanne Superstein, Maan Alkharashi, Michael Flanders, Claire Blais, and Melissa Louis

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, genetic structures, Visual Acuity, Ophthalmologic Surgical Procedures, Refraction, Ocular, 03 medical and health sciences, 0302 clinical medicine, Prism diopters, medicine, Humans, Surgical treatment, Aged, Retrospective Studies, Diplopia, Vision, Binocular, business.industry, Suture Techniques, Retrospective cohort study, General Medicine, Middle Aged, medicine.disease, eye diseases, Surgery, Ophthalmology, Oculomotor Muscles, 030221 ophthalmology & optometry, Exotropia, Female, medicine.symptom, business, Orthoptic, 030217 neurology & neurosurgery, Ophthalmologic Surgical Procedure, Cohort study
Abstract

This study had 3 objectives: (i) to characterize clinical profiles of adults with consecutive exotropia (CXT), intermittent exotropia (IXT), and sensory exotropia (SXT); (ii) to correlate immediate postoperative target angles with successful long-term ocular alignment; and (iii) to compare the efficacy of adjustable versus nonadjustable medial rectus resection ± advancement.Retrospective, observational, and interventional cohort study.A total of 133 adult exotropic patients treated surgically at 3 different hospitals between July 2012 and June 2013.The patients were divided according to clinical profiles (CXT, IXT, and SXT) based on ophthalmic and orthoptic assessments. Two treatment groups were established: group I-adjustable medial rectus resection ± advancement and adjustable lateral rectus recession; group II-nonadjustable medial resection ± advancement and adjustable lateral rectus recession. Measurements of immediate postadjustment alignment (target angle) and 4-6 months of follow-up alignment were performed and compared between groups. Surgical success was defined as distance primary position alignment within 10 prism diopters (PD) of orthotropia 4-6 months postoperatively.Comparison of clinical profile groups showed that CXT patients had more hyperopia and amblyopia and smaller preoperative deviations; IXT patients had more diplopia and larger preoperative deviations (neardistance); and SXT patients had poor vision in the deviating eye and larger preoperative deviations. Immediate postoperative alignment was 5.2 PD of esodeviation in group I and 3.2 PD of esodeviation in group II. Overall success rates for ocular alignment at 4-6 months postoperatively were comparable with both surgical techniques (74.6% for group I and 74.3% for group II). Patients with a preoperative deviation ≥40 PD had a lower surgical success rate (63.8%) than patients with a deviation40 PD (80%). Patients presenting with a significant (-1 or worse) abduction deficit in the operated eye at their first visit after surgery had a better success rate at 4-6 months' follow-up (83.3% vs 67.8%).Adjustable and nonadjustable medial rectus surgeries seem equally successful. Creation of an abduction deficit in the early postoperative period seems predictive of a better outcome. Larger preoperative angles (≥40 PD) were associated with more exotropic drift and a lower percentage of surgical success. Future studies will continue to search for surgical strategies and the ideal target angle that will produce the best long-term alignment stability.

Published
2016
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11. Tonic pupil after botulinum toxin-A injection for treatment of esotropia in children

Author

Rosanne Superstein, David K. Wallace, Raymond T. Kraker, Katherine A. Lee, Alejandra G. de Alba Campomanes, Stephen P. Christiansen, Julie Morin, Danielle L. Chandler, and Erick D. Bothun

Subjects
Male, medicine.medical_specialty, Adolescent, genetic structures, Pilot Projects, Tonic Pupil, Injections, Intramuscular, Article, Botulinum toxin a, 03 medical and health sciences, 0302 clinical medicine, Humans, Medicine, Botulinum Toxins, Type A, Child, Strabismus, Anisocoria, Esotropia, Tonic pupil, business.industry, Infant, Mean age, medicine.disease, eye diseases, Surgery, Ophthalmology, Left eye, Neuromuscular Agents, Oculomotor Muscles, Child, Preschool, Anesthesia, Pediatrics, Perinatology and Child Health, 030221 ophthalmology & optometry, Female, medicine.symptom, Complication, business, 030217 neurology & neurosurgery
Abstract

A total of 27 children with esotropia (mean age, 3.9 years; range, 9 months to 13.8 years) were enrolled in a 9-month observational study following botulinum toxin A (BTX-A) injection of one (n = 7) or both (n = 20) medial rectus muscles. BTX-A dosage ranged from 3.0 to 6.0 units per muscle. Three participants developed tonic pupil, noted at the first follow-up visit, occurring 12-19 days after injection. All 3 cases occurred in the left eye of participants who underwent bilateral BTX-A injection by the same surgeon. Anisocoria diminished from a maximum of 4 mm at the 2-week visit to 1–2 mm in all patients over the 9-month postinjection data collection period. No adverse visual outcomes were noted. Tonic pupil is an infrequently reported complication of BTX-A injection for strabismus. The experience of our investigator group suggests the need for careful injection technique and thorough preinjection counseling.

Published
2016
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12. A Randomized Clinical Trial Of Immediate versus Delayed Spectacles for Moderate Hyperopia in 1- and 2-Year-Olds

Author

John M. Avallone, Donny W. Suh, David B. Petersen, S. Ayse Erzurum, Alex Christoff, Trevano W. Dean, Raymond T. Kraker, Marjean Taylor Kulp, Jonathan M. Holmes, Ruth E. Manny, Tawna L Roberts, Rosanne Superstein, David K. Wallace, Susan A. Cotter, David A. Leske, and Deborah R. Fishman

Subjects
Male, Pediatrics, medicine.medical_specialty, genetic structures, Visual Acuity, Article, law.invention, Anisometropia, Time-to-Treatment, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, medicine, Humans, Vision test, Prospective Studies, Strabismus, Dioptre, 030304 developmental biology, 0303 health sciences, Depth Perception, business.industry, Vision Tests, Astigmatism, Infant, medicine.disease, Confidence interval, eye diseases, Stereoscopic acuity, Ophthalmology, Eyeglasses, Hyperopia, Prescriptions, Child, Preschool, 030221 ophthalmology & optometry, Patient Compliance, Female, business, Strabismus surgery, Follow-Up Studies
Abstract

OBJECTIVE: Two strategies were compared for managing moderate hyperopia without manifest strabismus among 1- and 2-year-old children: 1) immediate prescription of glasses vs 2) observation without glasses unless reduced distance visual acuity (VA), reduced stereoacuity, or manifest strabismus. DESIGN: Prospective randomized clinical trial PARTICIPANTS: 130 children 1 to 2 years old with hyperopia between +3.00 diopters (D) and +6.00D spherical equivalent (SE) in at least one eye, anisometropia ≤1.50D SE and astigmatism ≤1.50D based on cycloplegic refraction, and no manifest strabismus. METHODS: Participants were randomly assigned to glasses (1.00D less than full cycloplegic hyperopia) versus observation and followed every 6 months for 3 years. Glasses were prescribed to those assigned to observation if they met pre-specified deterioration criteria of distance VA or near stereoacuity below age norms, or development of manifest strabismus. MAIN OUTCOME MEASURE: At the 3-year primary outcome examination, participants were classified as failing the randomized management regimen if distance VA or stereoacuity were below age norms, or manifest strabismus was observed (each with and without correction in trial frames, confirmed by masked retest, irrespective of whether deterioration had occurred previously), or if strabismus surgery had been performed. RESULTS: Of the 106 (82%) participants completing the 3-year primary outcome examination, failure occurred in 11 (21%) of 53 in the glasses group and 18 (34%) of 53 in the observation group (difference = −13%; 95% CI = −31% to 4%; p=0.14). The reasons for failure in the glasses and observation groups were reduced stereoacuity in 6 (11%) and 16 (30%) respectively, reduced VA in 3 (6%) and 4 (8%), and manifest strabismus in 5 (9%) in each group. Fifty-eight percent (95% CI = 46% to 70%) in the observation group, and 33% (95% CI = 22% to 46%) in the glasses group met deterioration criteria (requiring glasses if not wearing). CONCLUSION: For 1- and 2-year-olds with uncorrected moderate hyperopia (+3.00D to +6.00D SE), our estimates of failure, after 3 years of 6-monthly follow-up, are inconclusive, and consistent with either a small to moderate benefit or no benefit of immediate prescription of glasses compared with careful observation (with glasses only if deteriorated).

Published
2019

13. The effects of the age of onset of strabismus on monocular and binocular visual function in genetically identical twins

Author

Rosanne Superstein, Robert F. Hess, Nicolas Cadet, Robert K. Koenekoop, and Pi-Chun Huang

Subjects
Adult, medicine.medical_specialty, genetic structures, Adolescent, media_common.quotation_subject, Ocular dominance, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Vision, Monocular, Ophthalmology, medicine, Diseases in Twins, Contrast (vision), Humans, Genetic Testing, Sibling, Strabismus, Child, media_common, Vision, Binocular, Monocular, business.industry, Age Factors, Infant, Newborn, Infant, General Medicine, Twins, Monozygotic, medicine.disease, Twin study, eye diseases, Child, Preschool, 030221 ophthalmology & optometry, Evoked Potentials, Visual, Female, sense organs, Age of onset, business, Esotropia, 030217 neurology & neurosurgery
Abstract

Objective Both genetic and environmental factors are thought to play a role in the pathogenesis of strabismus and subsequent ocular dominance and amblyopia. Our purpose was to compare the characteristics of sensory visual function in 2 adult monozygotic (genetically identical) twins who presented with esotropia at different ages. Methods Monocular and binocular visual function was measured in the twins. Contrast sensitivity was used to assess monocular function. Suppressive and stereoscopic measurements were undertaken to assess binocular function. All tests were run using a 2-alternative forced choice psychophysical procedure. Eighteen short tandem repeats (STR) were genotyped across the genome in both twins to determine their exact relationship. Results Twin 1 (nondominant eye OD) was diagnosed with esotropia at 6 months of age, whereas twin 2 (nondominant eye OS) was diagnosed with esotropia at 5 years of age. They underwent a similar corrective surgical intervention soon after diagnosis to correct their esodeviations. Monocular contrast sensitivity was poorer for twin 1, particularly at intermediate spatial frequencies. In addition, twin 1 demonstrated complete suppression and unmeasurable stereoscopic function (>300 seconds). On the other hand, twin 2 demonstrated fusion, exhibited only mild suppression, and had near-normal (28 seconds) stereoscopic function. All STR alleles were identical in the twins, proving monozygosity. Conclusions Sensory measurements of monocular and binocular visual function in these genetically proven monozygotic twins were significantly different, with the earlier onset of esotropia associated with reduced visual function. Twin 2, whose esotropia was diagnosed at the age of 5 years, had near-normal visual function, both monocularly and binocularly. To the best of our knowledge, this represents the first study of a genetically identical sibling pair with strabismus. By eliminating the genetic differences between these patients, we are able to make powerful observations about the effect of environment on visual function in strabismus.

Published
2017

14. Relationship among clinical factors in childhood intermittent exotropia

Author

Rosanne Superstein, Jonathan M. Holmes, Raymond T. Kraker, David K. Wallace, B. Michele Melia, R. Grey Weaver, Eileen E. Birch, Danielle L. Chandler, Sean P. Donahue, Susan A. Cotter, Brian G. Mohney, and Trevano W. Dean

Subjects
Male, medicine.medical_specialty, Visual acuity, Distance exotropia, Visual Acuity, Fixation, Ocular, Near exotropia, Article, Anisometropia, 03 medical and health sciences, 0302 clinical medicine, Ophthalmology, medicine, Humans, 030212 general & internal medicine, Child, Analysis of Variance, Depth Perception, business.industry, medicine.disease, Stereoscopic acuity, Child, Preschool, Pediatrics, Perinatology and Child Health, 030221 ophthalmology & optometry, Optometry, Exotropia, Minimum deviation, Female, medicine.symptom, business, Intermittent exotropia
Abstract

To determine the relationships between stereoacuity, control of exotropia, and angle of deviation in children with intermittent exotropia (IXT).Data collected for 652 participants 3 to11 years of age with IXT meeting eligibility criteria for enrollment into one of two multicenter, randomized clinical trials were used to evaluate relationships between stereoacuity, control, and angle of deviation at enrollment.Any level of stereoacuity and angle of deviation could be accompanied by any level of control. Worse distance exotropia control was weakly associated with poorer distance stereoacuity (R = 0.26; 99% CI, 0.17-0.36) and larger angles of deviation at distance (R = 0.27; 99% CI, 0.17-0.36). Worse near exotropia control was weakly associated with poorer near stereoacuity (R = 0.17; 99% CI, 0.07-0.27) and moderately associated with larger angles of deviation at near (R = 0.37; 99% CI, 0.28-0.45). There was no association between stereoacuity and angle of deviation at distance (R = 0.07; 99% CI, -0.03 to 0.17) or at near (R = 0.02; 99% CI, -0.08 to 0.12).Although weak and moderate associations were found between stereoacuity, control, and angle of deviation, a child may exhibit any combination of stereoacuity, control, and angle of deviation. The specific roles of control, stereoacuity, and angle of deviation in the diagnosis, management, and pathogenesis of IXT are unclear, and each appears to yield somewhat independent information.

Published
2017

15. Multiple Cranial Nerve Palsies in Giant Cell Arteritis

Author

Lulu L. C. D. Bursztyn, Rosanne Superstein, Mark Gans, and Michael G. Ross

Subjects
Male, Pathology, medicine.medical_specialty, Retinal Artery Occlusion, Eye Movements, Ocular motor, Biopsy, Giant Cell Arteritis, 03 medical and health sciences, 0302 clinical medicine, Ocular Motility Disorders, Medicine, Humans, Aged, Aged, 80 and over, medicine.diagnostic_test, business.industry, Ischemic optic neuropathy, medicine.disease, Cranial Nerve Diseases, Temporal Arteries, Ophthalmology, Giant cell arteritis, Oculomotor Muscles, 030221 ophthalmology & optometry, Neurology (clinical), Complication, business, 030217 neurology & neurosurgery, Systemic vasculitis
Abstract

Giant cell arteritis (GCA) is a systemic vasculitis of medium and large arteries often with ophthalmic involvement, including ischemic optic neuropathy, retinal artery occlusion, and ocular motor cranial nerve palsies. This last complication occurs in 2%-15% of patients, but typically involves only 1 cranial nerve. We present 2 patients with biopsy-proven GCA associated with multiple cranial nerve palsies.

Published
2017

17. Neurodevelopmental Outcomes Following Bevacizumab Injections for Retinopathy of Prematurity

Author

Prakesh S. Shah, Marie-Noëlle Simard, Vibhuti Shah, Luis H. Ospina, Julie Morin, Francine Lefebvre, Rosanne Superstein, Thuy Mai Luu, and Edmond Kelly

Subjects
Male, Canada, Pediatrics, medicine.medical_specialty, Composite score, Bevacizumab, Developmental Disabilities, Angiogenesis Inhibitors, Bayley Scales of Infant Development, 03 medical and health sciences, 0302 clinical medicine, Interquartile range, 030225 pediatrics, medicine, Humans, Retinopathy of Prematurity, Toddler, Retrospective Studies, business.industry, Infant, Newborn, Infant, Retinopathy of prematurity, Retrospective cohort study, medicine.disease, Motor Skills, Intravitreal Injections, Pediatrics, Perinatology and Child Health, 030221 ophthalmology & optometry, Female, Observational study, business, Infant, Premature, medicine.drug
Abstract

BACKGROUND AND OBJECTIVE: Bevacizumab intravitreal injection, a vascular endothelial growth factor inhibitor, is used to treat retinopathy of prematurity (ROP). However, concerns have been raised regarding its systemic absorption and effect on developing tissues including brain. This study compared neurodevelopment at 18 months’ corrected age in preterm infants of METHODS: Data from the Canadian Neonatal Network and the Canadian Neonatal Follow-Up Network databases were retrospectively reviewed. Infants born at RESULTS: Of 125 treated infants, 27 received bevacizumab and 98 laser. The bevacizumab group, compared with laser, obtained a median Bayley Scales of Infant and Toddler Development Third Edition motor composite score of 81 (interquartile range, 70–91) versus 88 (79–97), a language composite score of 79 (65–97) versus 89 (74–97), and a cognitive score of 90 (80–100) versus 90 (85–100). Difference was detected on the motor score only (P = .02). Odds of severe neurodevelopmental disabilities (Bayley scores CONCLUSIONS: Preterm infants treated with bevacizumab versus laser had higher odds of severe neurodevelopmental disabilities. Further investigation on the long-term safety of antivascular endothelial growth factor treatment of ROP is needed.

Published
2016
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18. Two Cases of Retinoblastoma Invading the Optic Nerve Sheath

Author

Anne Sophie Carret, Rosanne Superstein, Benjamin Ellezam, Patrick Hamel, and Lina H. Raffa

Subjects
medicine.medical_specialty, Optic nerve sheath, genetic structures, business.industry, Adjuvant chemotherapy, Retinoblastoma, General Medicine, medicine.disease, eye diseases, Metastasis, 03 medical and health sciences, Ophthalmology, 0302 clinical medicine, Pediatrics, Perinatology and Child Health, 030221 ophthalmology & optometry, Medicine, sense organs, Radiology, business, Strabismus, 030217 neurology & neurosurgery
Abstract

The authors report two cases of retinoblastoma with extension along the optic nerve sheath with negative surgical margins, a pattern not considered in current classifications but suggesting a high risk of metastasis. Both patients were treated with adjuvant chemotherapy alone and remain free of extraocular disease 15 and 22 months later. [ J Pediatr Ophthalmol Strabismus . 2016;53:e51–e53.]

Published
2016

19. Treatment of Periocular Infantile Hemangiomas with Propranolol: Case Series of 18 Children

Author

Rosanne Superstein, Ariane Milet, Julie Powell, Nicole Fallaha, François Codère, Line Chevrette, Rola Al Dhaybi, Patrick Hamel, Josée Dubois, Afshin Hatami, Catherine McCuaig, and Luis H. Ospina

Subjects
Male, medicine.medical_specialty, Vasodilator Agents, medicine.medical_treatment, Administration, Oral, Propranolol, Antiarrhythmic agent, Astigmatism, Eyelid Neoplasms, Hemangioma, Lesion, Occlusion, Humans, Medicine, Hemangioma, Capillary, Ultrasonography, Doppler, Color, Retrospective Studies, Dose-Response Relationship, Drug, business.industry, Vascular disease, Infant, medicine.disease, Magnetic Resonance Imaging, eye diseases, Surgery, Ophthalmology, Treatment Outcome, medicine.anatomical_structure, Female, Eyelid, Neoplasm Recurrence, Local, medicine.symptom, business, Follow-Up Studies, medicine.drug
Abstract

Purpose To study the efficacy of propranolol in the treatment of periocular infantile hemangiomas (IHs). Design Retrospective interventional case series. Participants Eighteen children presenting periocular IH with occlusion of the pupil, anisometropic astigmatism, proliferating eyelid IH, or cosmetically disfiguring periocular IH. Methods All patients received treatment with propranolol started at 0.5 mg/kg/day with an incremental increase by 0.5 mg/kg/day every 4 days, up to a maximum of 2 to 3 mg/kg/day. Complete eye examinations and serial photographs were obtained before, during, and after treatment. Doppler ultrasound and magnetic resonance imaging performed pre- and post-treatment were compared when available. Main Outcome Measures Evolution of the treated IH was evaluated with respect to astigmatism, amblyopia, and size of the lesion. Results The IH size decreased in 17 of 18 patients. We noted a greater reduction when treatment was administered during the proliferative phase of growth of IHs. At the conclusion of treatment, none of our patients had amblyopia. The mean value of amblyogenic astigmatism (n = 7) decreased from 2.71 diopters (D) pretreatment to 1.03 D post-treatment. On radiology, 8 patients had significant regression of the lesion size of their IH and 1 patient had a limited progression. Propranolol had to be temporarily discontinued in only 1 patient because of symptomatic hypotension. Conclusions Propranolol seems to be an effective modality of treatment for periocular IH. It seems to be most efficacious when initiated in the proliferative phase of IH but may be beneficial even in the later stage. Financial Disclosure(s) The author(s) have no proprietary or commercial interest in any materials discussed in this article.

Published
2011
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20. Treatment of Infantile Hemangiomas

Author

Suqin Guo, Michael G. Hunt, and Rosanne Superstein

Subjects
medicine.medical_specialty, business.industry, General Medicine, Propranolol, Eyelid Neoplasm, Astigmatism, medicine.disease, Surgery, Hemangioma, Ophthalmology, Pediatrics, Perinatology and Child Health, medicine, business, medicine.drug
Published
2010
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22. SYK is a target of lymphocyte-derived microparticles in the induction of apoptosis of human retinoblastoma cells

Author

Wei Xiong, Houda Tahiri, Anne-Sophie Carret, Qian Qiu, Pierre Hardy, Patrick Hamel, Benjamin Ellezam, Chun Yang, Guoxiang Liu, Mark Vezina, Mathieu Payeur, Bussières Martin, Rosanne Superstein, and Przemyslaw Sapieha

Subjects
Cyclin-Dependent Kinase Inhibitor p21, Cancer Research, Programmed cell death, Clinical Biochemistry, Pharmaceutical Science, Syk, Apoptosis, Biology, Proto-Oncogene Mas, Cell Line, Epigenesis, Genetic, Downregulation and upregulation, Cell-Derived Microparticles, Cell Line, Tumor, medicine, Cytotoxic T cell, Humans, Syk Kinase, Lymphocytes, Pharmacology, Retinoblastoma, Caspase 3, Biochemistry (medical), Intracellular Signaling Peptides and Proteins, Cell Biology, Protein-Tyrosine Kinases, medicine.disease, Cell biology, Up-Regulation, Cell culture, Cancer cell, Cancer research, Tumor Suppressor Protein p53
Abstract

Retinoblastoma (Rb) is an aggressive childhood cancer of the developing retina. This disease is associated with epigenetic deregulation of several cancer pathways including upregulation of the proto-oncogene spleen tyrosine kinase (SYK). We have previously demonstrated that lymphocyte-derived microparticles (LMPs) possess strong cytotoxic effect on cancer cells. This report demonstrated that LMPs have potent pro-apoptotic properties on human Rb cells, which was associated with a strong reduction of SYK expression. Perturbing SYK activity in Rb cells induced cell apoptosis and upregulated expression of p53 and p21. Interestingly, inhibition of p53 or knockdown of p21, abolished LMP-induced caspase-3 activity and cell death. Blocking oxidized phospholipid-rich LMPs with a specific antibody significantly prevented LMP-induced Rb apoptosis and reversed the expression patterns of SYK, p53, p21. In summary, our results suggest that LMPs are important pro-apoptotic regulators for Rb cells through reduction of SYK expression and upregulation of the p53-p21 pathway which ultimately activates caspase-3. These data may open unexpected avenues for the development of LMPs as a novel therapeutic strategy that would be particularly useful and relevant for the treatment of Rb.

Published
2015

23. First case of type IV hypersensitivity to periocular topotecan

Author

Anne-Sophie Carret, Rosanne Superstein, Anne Des Roches, Louis Paradis, Patrick Hamel, and François Graham

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, biology, business.industry, Camptotheca, Retinoblastoma, Immunology, biology.organism_classification, medicine.disease, Dermatology, Type IV hypersensitivity, 03 medical and health sciences, 0302 clinical medicine, 030228 respiratory system, 030221 ophthalmology & optometry, Immunology and Allergy, Medicine, Topotecan, business, medicine.drug
Published
2016
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24. Minimal myopic shift in pseudophakic versus aphakic pediatric cataract patients

Author

Steven M. Archer, Rosanne Superstein, and Monte A. Del Monte

Subjects
Adult, Refractive error, medicine.medical_specialty, Adolescent, Pseudophakia, genetic structures, medicine.medical_treatment, Emmetropia, Intraocular lens, Aphakia, Postcataract, Refraction, Ocular, Aphakia, Ophthalmology, Myopia, medicine, Humans, Child, Retrospective Studies, business.industry, Medical record, Infant, medicine.disease, eye diseases, Child, Preschool, Pediatrics, Perinatology and Child Health, Cohort, sense organs, Pediatric cataract, business
Abstract

To evaluate postoperative refractive changes in aphakic and pseudophakic children in a comparative case series.The medical records of pediatric patients with aphakia and pseudophakia were reviewed retrospectively. The mean change in refractive error from one postoperative examination to the next was calculated at each age to give aggregate curves of postoperative refractive change for each group.A total of 233 aphakic and 92 pseudophakic eyes were studied. The median age at the time of surgery was 0.8 years (range, 0.0-16 years) for patients with aphakia and 7.3 years (range, 1.5-19.9 years) for patients with pseudophakia (P.0001). The postoperative refraction curves at comparable ages of 2 to 20 years showed a total mean myopic shift of 1.5 D for patients with pseudophakia and 7.8 D for patients with aphakia. An age-matched subset of patients with aphakia also showed more myopic shift than those with pseudophakia.Pseudophakic eyes show less postoperative myopic shift than aphakic eyes. Selecting intraocular lens powers aimed at producing initial emmetropic refractions has been a good strategy in our cohort of patients with pseudophakia. However, our data are insufficient for conclusions regarding children with pseudophakia younger than 2 years, in whom larger myopic shifts may occur.

Published
2002
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25. Indications for cataract surgery

Author

Rosanne Superstein

Subjects
Cross-Cultural Comparison, Automobile Driving, medicine.medical_specialty, Activities of daily living, genetic structures, medicine.medical_treatment, Visual Acuity, MEDLINE, Cataract Extraction, Cataract, symbols.namesake, Sex Factors, Cataracts, Sickness Impact Profile, Activities of Daily Living, medicine, Humans, Vision test, Hippocratic Oath, business.industry, General surgery, General Medicine, Cataract surgery, medicine.disease, eye diseases, Review article, Ophthalmology, Harm, symbols, sense organs, business
Abstract

This review article will attempt to guide ophthalmologists in deciding the indications for cataract surgery. It will consider this year's visual function questionnaires, ancillary vision tests, and postoperative outcome measures to assess visual function. Cultural factors, age, and gender are a few of the confounding variables in trying to assess visual function. The indications for cataract surgery in the 21st century have evolved dramatically since cataract surgery was first performed in the 1700s. The physicians' dictum in the Hippocratic oath of "do no harm" has determined the indications for cataract surgery over time. Today, doing no harm means operating on cataracts earlier than previously, as this is technically easier than in previous years, when poorer surgical techniques prevailed. However, are we operating on cataracts too early? This review will attempt to highlight the relevant factors that will help to determine the indications for cataract surgery.

Published
2001
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26. A child with bilateral orbital cellulitis one day after strabismus surgery

Author

Rosanne Superstein and Ahmed Basheikh

Subjects
Male, medicine.medical_specialty, genetic structures, Streptococcus pyogenes, Postoperative Complications, Streptococcal Infections, medicine, Humans, Sinusitis, business.industry, Ceftriaxone, Orbital Cellulitis, medicine.disease, eye diseases, Anti-Bacterial Agents, Surgery, Strabismus, Ophthalmology, Child, Preschool, Concomitant, Pediatrics, Perinatology and Child Health, sense organs, Orbital cellulitis, Tomography, X-Ray Computed, business, Complication, Esotropia, Strabismus surgery
Abstract

Orbital cellulitis is a rare complication of strabismus surgery. We report a case of a 4-year-old boy with bilateral orbital cellulitis after uneventful surgery to correct esotropia. Concomitant sinusitis was the likely source of infection. To our knowledge, this is the first case of bilateral orbital cellulitis following strabismus surgery.

Published
2009
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27. Functional complaints, visual acuity,spatial contrast sensitivity, and glare disability in preoperative and postoperative cataract patients

Author

Don Boyaner, Olga Overbury, and Rosanne Superstein

Subjects
Adult, Male, medicine.medical_specialty, Visual acuity, genetic structures, medicine.medical_treatment, Eye disease, media_common.quotation_subject, Visual Acuity, Cataract, Glare, Contrast Sensitivity, Disability Evaluation, Surveys and Questionnaires, Ophthalmology, medicine, Humans, Contrast (vision), Vision test, Aged, media_common, Aged, 80 and over, Phacoemulsification, business.industry, Vision Tests, Glare (vision), Middle Aged, Cataract surgery, medicine.disease, eye diseases, Sensory Systems, Treatment Outcome, Patient Satisfaction, Decreased Visual Acuity, Optometry, Female, Surgery, sense organs, medicine.symptom, business, Follow-Up Studies
Abstract

Purpose: To quantify cataract patients' functional visual complaints and correlate them with their objective glare disability and spatial contrast sensitivity (SCS) scores. Setting: Sir Mortimer B. Davis Jewish General Hospital, Montreal, Quebec, Canada. Methods: Thirty patients scheduled for cataract surgery with a visual acuity of 20/70or better at the time of patient selection and no other ocular pathology were evaluated objectively and subjectively for visual function preoperatively and within 3 months postoperatively. Objective measures of SCS and visual acuity in the presence and absence of glare were obtained with the Optec 3000 vision tester. Subjective visual function was evaluated with the Activities of Daily Vision Scale (ADVS), a questionnaire that evaluates patients' visual function by assessing the degree of difficulty they experience in performing tasks involving distance vision, near vision, and glare conditions. Results: Preoperatively, patients had decreased visual acuity and SCS in the presence of glare. The ADVS scores were correlated with visual performance. Postoperatively, there was a statistically significant improvement in all dependent measures (i.e., visual acuity and SCS in the presence of glare) as well as in the subjective report of visual performance assessed by the ADVS. Conclusion: Spatial contrast sensitivity, glare disability, and the ADVS questionnaire should be considered as adjuncts to visual acuity testing in evaluating certain cataract patients.

Published
1999
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28. 81: Neurodevelopmental Outcomes of Extremely Preterm Infants Treated with Bevacizumab for Severe Retinopathy of Prematurity

Author

Marie-Noëlle Simard, Francine Lefebvre, Thuy Mai Luu, E Kelly, Julie Morin, V Shah, Prachi E. Shah, and Rosanne Superstein

Subjects
Pediatrics, medicine.medical_specialty, Bevacizumab, business.industry, Objective (goal), Birth weight, Extremely preterm, Retinopathy of prematurity, medicine.disease, Bayley Scales of Infant Development, Laser therapy, Pediatrics, Perinatology and Child Health, Medicine, business, medicine.drug
Published
2015
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29. Evaluation of the Intermittent Exotropia Questionnaire Using Rasch Analysis

Author

Daniel J. Karr, Michelle Bass, Rebecca Dent, Richard London, Laura B. Enyedi, Annette Bade, Wanda Pfeifer, Aaron M. Miller, Matthew D. Gearinger, B. Michele Melia, Monica Pacheco, Susan A. Cotter, Heather A Anderson, Heather Klem, Kenneth Adams, Joan Roberts, Donny W. Suh, Tammy Price, Sergul Erzurum, Ruth E. Manny, Ronald G.W. Teed, Peter Macdowell, Elise Harb, Melanie Christian, Reena Patel, Ann U. Stout, Troy Kieser, Raymond H. Chu, Anesu Mvududu, Vivian Wong, Tawna L Roberts, Angela Chen, Tamara S Oechslin, Richard L. Weaver, Michele Whitaker, Paula Rauch, Nancy Stevens, Elias I. Traboulsi, Karen Pollack, Noelle S. Matta, Robert P. Rutstein, Cheryl Capobianco, Paul G. Steinkuller, Gaylord Ventura, Carol Bradham, Mei Mellott, Darren L. Hoover, Jacqueline Rodena, Heidi Martin, Brian J. Forbes, Jill S. Anderson, Mary Louise Z. Collins, Robert Peters, Gil Binenbaum, Stephen P. Christiansen, Jayne Silver, Phoebe D. Lenhart, Marcela Frazier, Yasmin S. Bradfield, Kimberly G. Yen, Sara Meeder, Eileen Dittman, Lisa Fraine, Emi Sanders, Don Lyon, Nandini G. Gandhi, Wendy Marsh-Tootle, Pamela A. Huston, Ilana B Friedman, Lori Cooke, Beth Colon, Jonathan M. Holmes, Shelley Klein, Rosanne Superstein, Susannah Q. Longmuir, Sarah R. Hatt, Joan Do, Carmen Barnhardt, William F. Astle, Daniel E. Neely, Robert Duckman, Benjamin H. Ticho, Dipali Dave, Susanna M. Tamkins, Vanessa Vazquez, Rebecca Nielsen, Marilyn Vricella, Lernik Mesropian, Robert L. Estes, Gregory Ostrow, Laura Kirkeby, David G. Morrison, Andrew J. Toole, Nicole Fallaha, Paul J. Rychwalski, Kristy Dunlap, Susan Parker, Jeanine Romeo, David K. Wallace, Aaliyah Hamidullah, Edward Cheeseman, Mitchell Scheiman, David A. Leske, Caroline Belanger, Diana McOwen, Brian W. Arthur, Hee Jung Park, David I. Silbert, Tammy L. Yanovitch, David B. Petersen, Alex Christoff, Lesley Macsween, Sean P. Donahue, Xiaonong Liu, Eric Hein, David Robbins Tien, Lori Ann F. Kehler, Evelyn Koestenblatt, Indre M. Rudaitis, Jan Hilbrands, Sarah K. Jones, C. Gail Summers, Catherine Heyman, Jennifer Brady, Maynard Wheeler, Katherine K. Weise, Jorie Jackson, Ann M. Holleschau, Allison I. Summers, Kenneth Romanchuk, Megan Allen, Christie L. Morse, Inge De Becker, Sarah Downes, Tomohiko Yamada, Mitchell B. Strominger, Brian G. Mohney, David K. Coats, Susan Hayes, Freda Dallas, Amy K. Hutchinson, Deborah Clausius, Maryse Thibeault, Stacy L. Pineles, Lingkun Kong, Airaj Fasiuddin, Jeffery Colburn, Paula Handford, Blair Spencer, Tamiesha Frempong, Mae Millicent W. Peterseim, Hawke Yoon, Angela Alfaro, Catherine McDaniel, Jean E. Ramsey, Laura Liebermann, Laura Graham, Karen A. Karp, Stephen Van Iderstine, Earl R. Crouch, Evelyn A. Paysse, Alexander Khammar, Patricia L. Davis, J. McMurtrey, Bahram Rahmani, Judy Brower, Todd Goldblum, Yana Kiesau, Stephen R. Glaser, Scott R. Lambert, Karen D. Fern, Tara Cronin, Justin Smith, Maureen Flanagan, Marjean Taylor Kulp, Susan Crowe, Allison Jensen, Michael X. Repka, Adriana P. Grigorian, Nausheen Khuddus, Michael Bartiss, Ross Roegner, Faruk Ogre, Erick D. Bothun, Kristine Huang, Erin Herlihy, Daniel M. Laby, Mary A O'Hara, Tennille McGaw, Nicholas A. Sala, Samantha Garner, Mohamed A.W. Hussein, Barbara Soderling, Marianne Esguerra, and Yi Pang

Subjects
Male, medicine.medical_specialty, Adolescent, Cross-sectional study, Health Status, Article, Proxy (climate), Sickness Impact Profile, Surveys and Questionnaires, Humans, Medicine, Child, Rasch model, business.industry, Infant, Reproducibility of Results, medicine.disease, Ophthalmology, Cross-Sectional Studies, Child, Preschool, Cohort, Quality of Life, Physical therapy, Exotropia, Female, business, Intermittent exotropia, Psychosocial, Cohort study
Abstract

Importance The Intermittent Exotropia Questionnaire (IXTQ) is a patient, proxy, and parental report of quality of life specific to children with intermittent exotropia. We refine the IXTQ using Rasch analysis to improve reliability and validity. Observation Rasch analysis was performed on responses of 575 patients with intermittent exotropia enrolled from May 15, 2008, through July 24, 2013, and their parents from each of the 4 IXTQ health-related quality-of-life questionnaires (child 5 through 7 years of age and child 8 through 17 years of age, proxy, and parent questionnaires). Questionnaire performance and structure were confirmed in a separate cohort of 379 patients with intermittent exotropia. One item was removed from the 12-item child and proxy questionnaires, and response options in the 8- to 17-year-old child IXTQ and proxy IXTQ were combined into 3 response options for both questionnaires. Targeting was relatively poor for the child and proxy questionnaires. For the parent questionnaire, 3 subscales (psychosocial, function, and surgery) were evident. One item was removed from the psychosocial subscale. Resulting subscales had appropriate targeting. Conclusions and Relevance The Rasch-revised IXTQ may be a useful instrument for determining how intermittent exotropia affects health-related quality of life of children with intermittent exotropia and their parents, particularly for cohort studies.

Published
2015
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30. Retrobulbar hemorrhage following strabismus surgery

Author

Chantal Arès and Rosanne Superstein

Subjects
Male, medicine.medical_specialty, genetic structures, Ophthalmologic Surgical Procedures, Postoperative Hemorrhage, Diagnosis, Differential, Retrobulbar Hemorrhage, Medicine, Humans, Orbital hemorrhage, Esotropia, business.industry, Magnetic Resonance Imaging, eye diseases, Surgery, body regions, Periocular Injections, Ophthalmology, Retrobulbar injection, Oculomotor Muscles, Child, Preschool, Pediatrics, Perinatology and Child Health, sense organs, business, Complication, Tomography, X-Ray Computed, Strabismus surgery, Follow-Up Studies
Abstract

Retrobulbar hemorrhage, although a well-known complication of retrobulbar injection, periocular injections, and periocular surgeries, is not routinely associated with strabismus surgery. We present a case of delayed orbital hemorrhage occurring in a young boy 2 days after strabismus surgery.

Published
2005

32. Diverses modalités de traitement des troubles d’apprentissage scolaire par thérapies visuelles: quelles sont les évidences scientifiques?

Author

Isabelle Denault, Rosanne Superstein, Nicole Fallaha, and Amélie Ganivet

Subjects
General Medicine
Abstract

Les troubles d’apprentissage sont des désordres complexes qui entravent le développement normal des processus d’acquisition et de traitement de l’information. ils sont couramment rencontrés au sein de la population pédiatrique et peuvent se manifester sous diverses formes dont la plus fréquente est la dyslexie. Les troubles d’apprentissage ont une nature chronique et n’ont pas pour cause première des handicaps visuels, auditifs et/ ou moteurs, la déficience intellectuelle, la perturbation affective ni même un milieu défavorisé. Cependant, il est possible que ces troubles puissent coexister avec l’un ou l’autre de ces problèmes. Puisque les enfants qui en sont atteints rencontrent souvent des difficultés de taille lors des apprentissages fondamentaux dès leur entrée à l’école primaire, il est essentiel de leur offrir un soutien adapté, un diagnostic précoce et une intervention efficace. Plusieurs hypothèses impliquant divers problèmes visuels ont été émises quant à la cause de la dyslexie et des troubles d’apprentissage. La présente revue de littérature traite de ces diverses hypothèses de traitement des troubles d’apprentissage scolaire par thérapies visuelles. L’analyse démontre qu’il n’y a pas de preuves scientifiques suffisantes à ce jour prouvant que la thérapie visuelle, les lunettes d’entraînement, les exercices de poursuites et de saccades, les exercices perceptuels, les lunettes grossissantes, les filtres ou lentilles colorées ainsi que les prismes peuvent améliorer significativement les troubles d’apprentissage.

Published
2014
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34. Anterior dislocation of a posterior chamber intraocular lens after blunt trauma

Author

Mark Gans and Rosanne Superstein

Subjects
Male, Reoperation, medicine.medical_specialty, Visual acuity, genetic structures, Anterior Chamber, medicine.medical_treatment, Eye disease, Visual Acuity, Intraocular lens, Wounds, Nonpenetrating, Eye Injuries, Foreign-Body Migration, Lens Implantation, Intraocular, Ophthalmology, medicine, Humans, Aged, Aged, 80 and over, Lenses, Intraocular, business.industry, Sequela, equipment and supplies, medicine.disease, eye diseases, Sensory Systems, Surgery, Posterior chamber intraocular lens, Blunt trauma, sense organs, medicine.symptom, business
Abstract

An 85-year-old man developed an anterior dislocation of a posterior chamber intraocular lens (IOL) after blunt trauma. The dislocated IOL was exchanged for an anterior chamber IOL. Visual acuity was 20/40 at the 6 month follow-up. This case presents an unusual sequela of trauma to a pseudophakic eye and discusses management issues that should be considered.

Published
1999

35. Glare disability and contrast sensitivity before and after cataract surgery

Author

Don Boyaner, Charles A. Collin, Rosanne Superstein, and Olga Overbury

Subjects
Adult, Male, medicine.medical_specialty, Visual acuity, genetic structures, medicine.medical_treatment, Eye disease, media_common.quotation_subject, Vision Disorders, Visual Acuity, After cataract, Cataract Extraction, Cataract, Glare, Contrast Sensitivity, Ophthalmology, medicine, Postoperative results, Contrast (vision), Humans, media_common, Aged, Aged, 80 and over, business.industry, Glare (vision), Cataract surgery, Middle Aged, medicine.disease, eye diseases, Sensory Systems, Surgery, Glare disability, Female, sense organs, medicine.symptom, business
Abstract

Purpose: To determine whether brightness-induced glare decreases spatial contrast sensitivity and visual acuity in preoperative cataract patients with functional visual complaints and to compare preoperative with postoperative results. Setting: Sir Mortimer B. Davis Jewish General Hospital, Montreal, Quebec, Canada. Methods: Twenty patients with a visual acuity of 20/70 or better at the time of chart selection and no other ocular pathology who were referred for cataract surgery were evaluated with the Optec 3000 vision tester to assess contrast sensitivity and visual acuity in the presence and absence of glare. Testing was done preoperatively and 1 and 3 months postoperatively. Results: An analysis of variance indicated that there were statistically significant double interactions between the preoperative/postoperative and glare/no-glare variables and between the preoperative/postoperative and spatial frequency variables. Postoperatively, visual acuity and contrast sensitivity improved to within normal limits. There were no statistically significant differences in visual acuity and spatial contrast sensitivity between 1 and 3 months postoperatively. Conclusion: Spatial contrast sensitivity and glare testing provided objective assessment of patients who had good visual acuity yet also had functional complaints.

Published
1997

36. Real-time Ophthalmoscopic Findings of Intraophthalmic Artery Chemotherapy in Retinoblastoma

Author

Anne Sophie Carret, Josée Dubois, Patrick Hamel, Rosanne Superstein, S.A. Callejo, and Nicole Fallaha

Subjects
medicine.medical_specialty, Chemotherapy, medicine.diagnostic_test, business.industry, Retinoblastoma, medicine.medical_treatment, medicine.disease, Chemotherapy regimen, Ophthalmoscopy, Ophthalmology, medicine.anatomical_structure, Medicine, Radiology, business, Artery
Published
2012
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37. Propranolol for the treatment of periocular capillary hemangiomas

Author

Afshin Hatami, Rosanne Superstein, Josée Dubois, Patrick Hamel, François Codère, Rola Al Dhaybi, Lyne Chevrette, Julie Powell, Nicole Fallaha, Ariane Milet, Luis H. Ospina, and Catherine McCuaig

Subjects
Ophthalmology, medicine.medical_specialty, business.industry, Capillary hemangioma, Pediatrics, Perinatology and Child Health, Medicine, Propranolol, business, medicine.disease, medicine.drug
Published
2010
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