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4. Personalized pathology test for Cardio-vascular disease: Approximate Bayesian computation with discriminative summary statistics learning

Author

Dutta, Ritabrata, Zouaoui-Boudjeltia, Karim, Kotsalos, Christos, Rousseau, Alexandre, de Sousa, Daniel Ribeiro, Desmet, Jean-Marc, Van Meerhaeghe, Alain, Mira, Antonietta, and Chopard, Bastien

Subjects
Statistics - Methodology, Statistics - Computation, Statistics - Machine Learning
Abstract

Cardio/cerebrovascular diseases (CVD) have become one of the major health issue in our societies. But recent studies show that the present pathology tests to detect CVD are ineffectual as they do not consider different stages of platelet activation or the molecular dynamics involved in platelet interactions and are incapable to consider inter-individual variability. Here we propose a stochastic platelet deposition model and an inferential scheme to estimate the biologically meaningful model parameters using approximate Bayesian computation with a summary statistic that maximally discriminates between different types of patients. Inferred parameters from data collected on healthy volunteers and different patient types help us to identify specific biological parameters and hence biological reasoning behind the dysfunction for each type of patients. This work opens up an unprecedented opportunity of personalized pathology test for CVD detection and medical treatment.

Published
2020

5. Direct measurement of the electron energy relaxation dynamics in metallic wires

Author

Pinsolle, Edouard, Rousseau, Alexandre, Lupien, Christian, and Reulet, Bertrand

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

We present measurements of the dynamical response of thermal noise to an ac excitation in conductors at low temperature. From the frequency dependence of this response function - the noise thermal impedance - in the range 1 kHz-1 GHz we obtain direct determinations of the inelastic relaxation times relevant in metallic wires at low temperature: the electron-phonon scattering time and the diffusion time of electrons along the wires. Combining these results with that of resistivity provides a measurement of heat capacity of samples made of thin film. The simplicity and reliability of this technique makes it very promising for future applications in other systems., Comment: 5 pages, 4 figures

Published
2016
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6. Les aptitudes organisationnelles et d’affaires: pour faire rayonner votre expertise juridique!

Author

ROUSSEAU, ALEXANDRE

Subjects
ORGANIZATIONAL accountability, NOTARIES, PROFESSIONALISM, PRACTICE of law, NOTARIES' offices
Abstract

The article focuses on the importance of organizational and business skills for notaries to enhance their professional effectiveness. Topics include the definition and relevance of these skills, strategies for developing them, and how they can help notaries adapt to a changing environment and improve their practice.

Published
2024

23. Les pas d'allure de Alexandre Leblanc (2022).

Author

ROUSSEAU, ALEXANDRE FONTAINE

Subjects
ANIMATED films, SILENT films, DISILLUSIONMENT, FRUSTRATION, FILMMAKERS, FILMMAKING, SPECIAL effects (Motion pictures)
Abstract

The article provides an overview of the film "Les pas d'allure," which explores themes of anger, disillusionment, and media manipulation. The director, Alexandre Leblanc, expresses his frustration with the world through the film and uses animation to create special effects. Despite limited resources, the film was made with the help of friends and a talented cast and crew. The narrative structure of the film was developed during the editing process, with improvisation playing a significant role. Approximately 75% of the film, including dialogue and performances, was improvised. "Les pas d'allure" was presented at the Fantasia festival and is described as a comedy that defies categorization. The director draws inspiration from other Quebecois filmmakers and artistic movements, such as silent films and the psychedelic culture of the 1960s. The production of the film took five years, allowing for the development of ideas and influence from external sources. [Extracted from the article]

Published
2023

27. Red Blood Cell Shape and Deformability in Patients With COVID-19 Acute Respiratory Distress Syndrome.

Author

Piagnerelli, Michaël, Vanderelst, Jean-Christophe, Rousseau, Alexandre, Monteyne, Daniel, Perez-Morga, David, Biston, Patrick, Zouaoui Boudjeltia, Karim, Piagnerelli, Michaël, Vanderelst, Jean-Christophe, Rousseau, Alexandre, Monteyne, Daniel, Perez-Morga, David, Biston, Patrick, and Zouaoui Boudjeltia, Karim

Abstract

Acute respiratory distress syndrome due to coronavirus disease 2019 (COVID-19) is associated with high mortality. Several studies have reported that the microcirculation responds adequately to hypoxia in COVID-19 patients by increasing oxygen availability, in contrast to the inadequate response observed in patients with bacterial sepsis. Red blood cells (RBCs), the key cells for oxygen transport, and notably their rheology, are altered during bacterial sepsis, but few data are available in patients with COVID-19., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2022

28. Personalized pathology test for Cardiovascular disease: Approximate Bayesian computation with discriminative summary statistics learning

Author

Dutta, Ritabrata, Zouaoui Boudjeltia, Karim, Kotsalos, Christos, Rousseau, Alexandre, Ribeiro De Sousa, Daniel, Desmet, Jean-Marc, Van Meerhaeghe, Alain, Mira, Antonietta, Chopard, Bastien, Dutta, Ritabrata, Zouaoui Boudjeltia, Karim, Kotsalos, Christos, Rousseau, Alexandre, Ribeiro De Sousa, Daniel, Desmet, Jean-Marc, Van Meerhaeghe, Alain, Mira, Antonietta, and Chopard, Bastien

Abstract

Cardio/cerebrovascular diseases (CVD) have become one of the major health issue in our societies. But recent studies show that the present pathology tests to detect CVD are ineffectual as they do not consider different stages of platelet activation or the molecular dynamics involved in platelet interactions and are incapable to consider inter-individual variability. Here we propose a stochastic platelet deposition model and an inferential scheme to estimate the biologically meaningful model parameters using approximate Bayesian computation with a summary statistic that maximally discriminates between different types of patients. Inferred parameters from data collected on healthy volunteers and different patient types help us to identify specific biological parameters and hence biological reasoning behind the dysfunction for each type of patients. This work opens up an unprecedented opportunity of personalized pathology test for CVD detection and medical treatment., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2022

29. Three-dimensional analysis of blood platelet spreading using digital holographic microscopy: a statistical study of the differential effect of coatings in healthy volunteers and dialyzed patients

Author

Dohet-Eraly, Jérôme, Zouaoui Boudjeltia, Karim, Rousseau, Alexandre, Queeckers, Patrick, Lelubre, Christophe, Desmet, Jean-Marc, Chopard, Bastien, Yourassowsky, Catherine, Dubois, Frank, Dohet-Eraly, Jérôme, Zouaoui Boudjeltia, Karim, Rousseau, Alexandre, Queeckers, Patrick, Lelubre, Christophe, Desmet, Jean-Marc, Chopard, Bastien, Yourassowsky, Catherine, and Dubois, Frank

Abstract

In cardiovascular disorders, the study of thrombocytes, commonly known as platelets, is highly important since they are involved in blood clotting, essential in hemostasis, and they can in pathological situations affect the blood circulation. In this paper, single deposited platelets are measured using interferometric digital holographic microscopy. We have shown that the average optical height of platelets is significantly lower in healthy volunteers than in dialyzed patients, meaning a better spreading. It demonstrates the great interest for assessing this parameter in any patients, and therefore the high potential of analyzing single spread platelets using digital holographic microscopy in fundamental research as well as a diagnostic tool in routine laboratories, for usual blood tests., info:eu-repo/semantics/published

Published
2022

31. Simultaneous measurement of protein-bound 3-chlorotyrosine and homocitrulline by LC–MS/MS after hydrolysis assisted by microwave: Application to the study of myeloperoxidase activity during hemodialysis

Author

Delporte, Cédric, Franck, Thierry, Noyon, Caroline, Dufour, Damien, Rousseau, Alexandre, Madhoun, Philippe, Desmet, Jean-Marc, Serteyn, Didier, Raes, Martine, Nortier, Joëlle, Vanhaeverbeek, Michel, Moguilevsky, Nicole, Nève, Jean, Vanhamme, Luc, Van Antwerpen, Pierre, and Zouaoui Boudjeltia, Karim

Published
2012
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38. Three-dimensional analysis of blood platelet spreading using digital holographic microscopy: a statistical study of the differential effect of coatings in healthy volunteers and dialyzed patients

Author

Dohet-Eraly, Jérôme, primary, Boudjeltia, Karim Zouaoui, additional, Rousseau, Alexandre, additional, Queeckers, Patrick, additional, Lelubre, Christophe, additional, Desmet, Jean-Marc, additional, Chopard, Bastien, additional, Yourassowsky, Catherine, additional, and Dubois, Frank, additional

Published
2021
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40. Contributors

Author

Abbott, Jonathan A., primary, Adamantos, Sophie, additional, Adin, Christopher A., additional, Allen-Durrance, Ashley E., additional, Armentano, Robert A., additional, Aronson, Lillian R., additional, Balakrishnan, Anusha, additional, Beal, Matthew W., additional, Berent, Allyson, additional, Boag, Amanda K., additional, Boller, Elise Mittleman, additional, Boller, Manuel, additional, Boothe, Dawn Merton, additional, Borchers, Angela, additional, Boysen, Søren R., additional, Brainard, Benjamin M., additional, Brown, Andrew J., additional, Brown, Scott, additional, Burkitt, Jamie M., additional, Casal, Margret L., additional, Caulfield, Ann M., additional, Chan, Daniel L., additional, Chapman, Peter S., additional, Chastain, C.B., additional, Chew, Dennis J., additional, Clarke, Dana L., additional, Claus, Melissa A., additional, Cohn, Leah A., additional, Cooper, Edward, additional, Côté, Etienne, additional, Crane, M. Bronwyn, additional, Culp, William T.N., additional, Daly, Meredith L., additional, Davis, Emily, additional, Davis, Harold, additional, de Laforcade, Armelle, additional, DeFrancesco, Teresa, additional, Dixon-Jimenez, Amy, additional, Donahue, Suzanne, additional, Dowling, Patricia M., additional, Drobatz, Kenneth J., additional, Eatroff, Adam E., additional, Edwards, Melissa, additional, Eirmann, Laura, additional, Epstein, Steven, additional, Fletcher, Daniel J., additional, Francey, Thierry, additional, Fudge, Mack, additional, Garzotto, Caroline K., additional, Gaynor, Alison R., additional, Giger, Urs, additional, Giunti, Massimo, additional, Goggs, Robert A.N., additional, Goldstein, Richard E., additional, Green, Todd A., additional, Groman, Reid P., additional, Guillaumin, Julien, additional, Hackett, Tim B., additional, Hackner, Susan G., additional, Haldane, Sarah, additional, Hallowell, Terry C., additional, Harvey, Ralph C., additional, Haskins, Steve C., additional, Hayes, Galina, additional, Hess, Rebecka S., additional, Hoareau, Guillaume L., additional, Hogan, Daniel F., additional, Hollingsworth, Steven R., additional, Holmberg, Bradford J., additional, Holt, David, additional, Hopper, Kate, additional, Hughes, Dez, additional, Hume, Daniel Z., additional, Humm, Karen R., additional, Jandrey, Karl E., additional, Jasani, Shailen, additional, Johnson, Lynelle R., additional, Jutkowitz, L. Ari, additional, Kanakubo, Kayo, additional, Kerl, Marie E., additional, King, Lesley G., additional, Knipe, Marguerite F., additional, Koenig, Amie, additional, Labato, Mary Anna, additional, Langston, Catherine E., additional, Larsen, Jennifer A., additional, Larson, Victoria S., additional, LeCouteur, Richard A., additional, Lee, Justine A., additional, Lewis, Daniel Huw, additional, Li, Ronald, additional, Liu, Debra T., additional, MacDonald, Kristin A., additional, Machen, Maggie C., additional, Madden, Valerie, additional, Maglaras, Christina, additional, Mandell, Deborah C., additional, Mann, F.A. (Tony), additional, Martin, Linda G., additional, Massicotte, Christiane, additional, Mathews, Karol A., additional, Mazzaferro, Elisa M., additional, McIntyre, Robin L., additional, McMichael, Maureen, additional, Mehl, Margo, additional, Mellema, Matthew S., additional, Michel, Kathryn E., additional, Miller, Carrie J., additional, Miller, James B., additional, Moeser, Adam, additional, Otto, Cynthia M., additional, Oura, Trisha J., additional, Oyama, Mark A., additional, Palm, Carrie A., additional, Papich, Mark G., additional, Pariaut, Romain, additional, Perkowski, Sandra, additional, Pich, Michele, additional, Platt, Simon R., additional, Powell, Lisa Leigh, additional, Prošek, Robert, additional, Pypendop, Bruno H., additional, Quandt, Jane, additional, Rahilly, Louisa J., additional, Ralph, Alan G., additional, Rankin, Shelley C., additional, Rebar, Alan H., additional, Reineke, Erica L., additional, Reiss, Adam J., additional, Reynolds, Caryn, additional, Riordan, Laura L., additional, Robben, Joris H., additional, Robinson, Narda G., additional, Rondeau, Mark P., additional, Rosenstein, Patricia G., additional, Rousseau, Alexandre, additional, Rozanski, Elizabeth A., additional, Rudloff, Elke, additional, Santoro-Beer, Kari, additional, Sauvé, Valérie, additional, Savino, Emily, additional, Schaer, Michael, additional, Serrano, Sergio, additional, Sharp, Claire R., additional, Shaw, Scott P., additional, Sigrist, Nadja E., additional, Silverstein, Deborah C., additional, Sleeper, Meg, additional, Smarick, Sean, additional, Smart, Lisa, additional, Sorrell-Raschi, Laurie, additional, Steinberg, Sheldon A., additional, Stewart, Randolph H., additional, Sturges, Beverly K., additional, Sykes, Jane E., additional, Syring, Rebecca S., additional, Todd, Jeffrey M., additional, Trotman, Tara K., additional, Vernau, Karen M., additional, Villaverde, Cecilia, additional, Vite, Charles H., additional, Volk, Susan W., additional, Waddell, Lori S., additional, Wang, Andrea, additional, Ward, Cynthia R., additional, Ware, Wendy A., additional, Wey, Aaron C., additional, Willard, Michael D., additional, Winkler, Kevin P., additional, Wright, Annie Malouin, additional, Wright, Bonnie, additional, and Wright, Kathy N., additional

Published
2015
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44. Les pas d'allure.

Author

ROUSSEAU, ALEXANDRE FONTAINE

Subjects
LIBERALISM, REVENGE, CREATIVE ability, JOY, LIBERTY
Abstract

"Les pas d'allure" is a film that tells a chaotic and fantastical story of revenge and heist. The film is improvised and filled with spontaneous moments, creating a sense of freedom and creativity. While the plot may not withstand close analysis, the film captures a certain sentiment of alienation in a Quebec society dominated by economic liberalism. Despite its apocalyptic ending, the film is not defeatist, but rather showcases a unique energy and joy of creation in the current landscape of Quebec cinema. [Extracted from the article]

Published
2023

49. Investigating the two regimes of fibrin clot lysis: an experimental and computational approach

Author

Raynaud, Franck, Rousseau, Alexandre, Monteyne, Daniel, Perez-Morga, David, Zouaoui Boudjeltia, Karim, Chopard, Bastien, Raynaud, Franck, Rousseau, Alexandre, Monteyne, Daniel, Perez-Morga, David, Zouaoui Boudjeltia, Karim, and Chopard, Bastien

Abstract

It has been observed in vitro that complete clot lysis is generally preceded by a slow phase of lysis during which the degradation seems to be inefficient. However, this slow regime was merely noticed, but not yet quantitatively discussed. In our experiments, we observed that the lysis ubiquitously occurred in two distinct regimes, a slow and a fast lysis regime. We quantified extensively the duration of these regimes for a wide spectrum of experimental conditions and found that on average, the slow regime lasts longer than the fast one, meaning that during most of the process, the lysis is ineffective. We proposed a computational model in which the properties of the binding of the proteins change during the lysis: first, the biochemical reactions take place at the surface of the fibrin fibers, then in the bulk, resulting in the observed fast lysis regime. This simple hypothesis appeared to be sufficient to reproduce with a great accuracy the lysis profiles obtained experimentally., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2021

50. M2 Monocyte Polarization in Dialyzed Patients Is Associated with Increased Levels of M-CSF and Myeloperoxidase-Associated Oxidative Stress: Preliminary Results.

Author

Pireaux, Valérie, Delporte, Cédric, Rousseau, Alexandre, Desmet, Jean-Marc, Van Antwerpen, Pierre, Raes, Martine, Zouaoui Boudjeltia, Karim, Pireaux, Valérie, Delporte, Cédric, Rousseau, Alexandre, Desmet, Jean-Marc, Van Antwerpen, Pierre, Raes, Martine, and Zouaoui Boudjeltia, Karim

Abstract

Cardiovascular diseases represent a major issue in terms of morbidity and mortality for dialysis patients. This morbidity is due to the accelerated atherosclerosis observed in these patients. Atherosclerosis is a chronic inflammatory disease characterized by key players such as monocytes, macrophages, or oxidized LDLs. Monocytes-macrophages are classified into subsets of polarized cells, with M1 and M2 macrophages considered, respectively, as pro- and anti-inflammatory. (1) Methods: The monocyte subsets and phenotypes were analyzed by flow cytometry. These data were completed by the quantification of plasma M-CSF, IL-8, CRP, Mox-LDLs, Apo-B, Apo-AI, chloro-tyrosine, and homocitrulline concentrations. The statistical differences and associations between two continuous variables were assessed using the Mann-Whitney U test and Spearman's correlation coefficient, respectively. (2) Results: Hemodialyzed patients showed a significant increase in their concentrations of CRP, M-CSF, and IL-8 (inflammation biomarkers), as well as chloro-tyrosine and homocitrulline (myeloperoxidase-associated oxidative stress biomarkers). Moreover, we observed a higher percentage of M2 monocytes in the plasma of hemodialysis patients as compared to the controls. (3) Conclusions: Our data suggest that oxidative stress and an inflammatory environment, which is amplified in hemodialysis patients, seems to favor an increase in the concentration of circulating M-CSF, therefore leading to an increase in M2 polarization among circulating monocytes., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2021

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