Search

Your search keyword '"Rusch, Elisa"' showing total 20 results
Start Over Author "Rusch, Elisa"
20 results on '"Rusch, Elisa"'

2. Actively personalized vaccination trial for newly diagnosed glioblastoma

Author

Hilf, Norbert, Kuttruff-Coqui, Sabrina, Frenzel, Katrin, Bukur, Valesca, Stevanović, Stefan, Gouttefangeas, Cécile, Platten, Michael, Tabatabai, Ghazaleh, Dutoit, Valerie, van der Burg, Sjoerd H., thor Straten, Per, Martínez-Ricarte, Francisco, Ponsati, Berta, Okada, Hideho, Lassen, Ulrik, Admon, Arie, Ottensmeier, Christian H., Ulges, Alexander, Kreiter, Sebastian, von Deimling, Andreas, Skardelly, Marco, Migliorini, Denis, Kroep, Judith R., Idorn, Manja, Rodon, Jordi, Piró, Jordi, Poulsen, Hans S., Shraibman, Bracha, McCann, Katy, Mendrzyk, Regina, Löwer, Martin, Stieglbauer, Monika, Britten, Cedrik M., Capper, David, Welters, Marij J. P., Sahuquillo, Juan, Kiesel, Katharina, Derhovanessian, Evelyna, Rusch, Elisa, Bunse, Lukas, Song, Colette, Heesch, Sandra, Wagner, Claudia, Kemmer-Brück, Alexandra, Ludwig, Jörg, Castle, John C., Schoor, Oliver, Tadmor, Arbel D., Green, Edward, Fritsche, Jens, Meyer, Miriam, Pawlowski, Nina, Dorner, Sonja, Hoffgaard, Franziska, Rössler, Bernhard, Maurer, Dominik, Weinschenk, Toni, Reinhardt, Carsten, Huber, Christoph, Rammensee, Hans-Georg, Singh-Jasuja, Harpreet, Sahin, Ugur, Dietrich, Pierre-Yves, and Wick, Wolfgang

Published
2019
Full Text
View/download PDF

4. A new synthetic toll-like receptor 1/2 ligand is an efficient adjuvant for peptide vaccination in a human volunteer

Author

Rammensee, Hans-Georg, Wiesmüller, Karl-Heinz, Chandran, P. Anoop, Zelba, Henning, Rusch, Elisa, Gouttefangeas, Cécile, Kowalewski, Daniel J., Di Marco, Moreno, Haen, Sebastian P., Walz, Juliane S., Gloria, Yamel Cardona, Bödder, Johanna, Schertel, Jill-Marie, Tunger, Antje, Müller, Luise, Kießler, Maximilian, Wehner, Rebekka, Schmitz, Marc, Jakobi, Meike, Schneiderhan-Marra, Nicole, Klein, Reinhild, Laske, Karoline, Artzner, Kerstin, Backert, Linus, Schuster, Heiko, Schwenck, Johannes, Weber, Alexander N. R., Pichler, Bernd J., Kneilling, Manfred, la Fougère, Christian, Forchhammer, Stephan, Metzler, Gisela, Bauer, Jürgen, Weide, Benjamin, Schippert, Wilfried, Stevanović, Stefan, and Löffler, Markus W.

Published
2019
Full Text
View/download PDF

8. Publisher Correction: Actively personalized vaccination trial for newly diagnosed glioblastoma

Author

Hilf, Norbert, Kuttruff-Coqui, Sabrina, Frenzel, Katrin, Bukur, Valesca, Stevanović, Stefan, Gouttefangeas, Cecile, Platten, Michael, Tabatabai, Ghazaleh, Dutoit, Valerie, van der Burg, Sjoerd H., Straten, Per thor, Martinez-Ricarte, Francisco, Ponsati, Berta, Okada, Hideho, Lassen, Ulrik, Admon, Arie, Ottensmeier, Christian H., Ulges, Alexander, Kreiter, Sebastian, von Deimling, Andreas, Skardelly, Marco, Migliorini, Denis, Kroep, Judith R., Idorn, Manja, Rodon, Jordi, Piro, Jordi, Poulsen, Hans S., Shraibman, Bracha, McCann, Katy, Mendrzyk, Regina, Lower, Martin, Stieglbauer, Monika, Britten, Cedrik M., Capper, David, Welters, Marij J. P., Sahuquillo, Juan, Kiesel, Katharina, Derhovanessian, Evelyna, Rusch, Elisa, Bunse, Lukas, Song, Colette, Heesch, Sandra, Wagner, Claudia, Kemmer-Bruck, Alexandra, Ludwig, Jorg, Castle, John C., Schoor, Oliver, Tadmor, Arbel D., Green, Edward, Fritsche, Jens, Meyer, Miriam, Pawlowski, Nina, Dorner, Sonja, Hoffgaard, Franziska, Rossler, Bernhard, Maurer, Dominik, Weinschenk, Toni, Reinhardt, Carsten, Huber, Christoph, Rammensee, Hans-Georg, Singh-Jasuja, Harpreet, Sahin, Ugur, Dietrich, Pierre-Yves, and Wick, Wolfgang

Published
2019
Full Text
View/download PDF

9. Simultaneous Identification of Functional Antigen-Specific CD8 + and CD4 + Cells after In Vitro Expansion Using Elongated Peptides.

Author

Schuhmacher, Juliane, Kleemann, Leon, Richardson, Jennifer Rebecca, Rusch, Elisa, Rammensee, Hans-Georg, and Gouttefangeas, Cécile

Subjects
T cells, PEPTIDES, CD8 antigen, CD4 antigen, FUNCTIONAL analysis, EPITOPES
Abstract

Elongated peptides (EPs), containing possibly one or multiple epitope/s, are increasingly used for the screening of antigen-specific CD8+ and CD4+ cell responses. Here, we present an in vitro protocol that allows the amplification of antigen-specific cells and the subsequent functional analysis of both T cell types using EPs. Known viral-derived epitopes were elongated to 20 mer EPs on the N-, C-, and both termini for HLA class I binders, or on the N- and C- termini for HLA class II binders. With EP stimulation only, the percentage of responding CD8+ T cells was dependent on the elongation site of the EP, whereas CD4+ T cell responses were completely lost in 22% of the tests performed ex vivo. A short-term amplification step plus the addition of a TLR3 agonist (Poly-ICLC) together with an increased EP concentration improved markedly the detection of CD8+ and CD4+ T cell reactivities. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

10. Actively personalized vaccination trial for newly diagnosed glioblastoma

Author

Hilf, Norbert, primary, Kuttruff-Coqui, Sabrina, additional, Frenzel, Katrin, additional, Bukur, Valesca, additional, Stevanović, Stefan, additional, Gouttefangeas, Cécile, additional, Platten, Michael, additional, Tabatabai, Ghazaleh, additional, Dutoit, Valerie, additional, van der Burg, Sjoerd H., additional, thor Straten, Per, additional, Martínez-Ricarte, Francisco, additional, Ponsati, Berta, additional, Okada, Hideho, additional, Lassen, Ulrik, additional, Admon, Arie, additional, Ottensmeier, Christian H., additional, Ulges, Alexander, additional, Kreiter, Sebastian, additional, von Deimling, Andreas, additional, Skardelly, Marco, additional, Migliorini, Denis, additional, Kroep, Judith R., additional, Idorn, Manja, additional, Rodon, Jordi, additional, Piró, Jordi, additional, Poulsen, Hans S., additional, Shraibman, Bracha, additional, McCann, Katy, additional, Mendrzyk, Regina, additional, Löwer, Martin, additional, Stieglbauer, Monika, additional, Britten, Cedrik M., additional, Capper, David, additional, Welters, Marij J. P., additional, Sahuquillo, Juan, additional, Kiesel, Katharina, additional, Derhovanessian, Evelyna, additional, Rusch, Elisa, additional, Bunse, Lukas, additional, Song, Colette, additional, Heesch, Sandra, additional, Wagner, Claudia, additional, Kemmer-Brück, Alexandra, additional, Ludwig, Jörg, additional, Castle, John C., additional, Schoor, Oliver, additional, Tadmor, Arbel D., additional, Green, Edward, additional, Fritsche, Jens, additional, Meyer, Miriam, additional, Pawlowski, Nina, additional, Dorner, Sonja, additional, Hoffgaard, Franziska, additional, Rössler, Bernhard, additional, Maurer, Dominik, additional, Weinschenk, Toni, additional, Reinhardt, Carsten, additional, Huber, Christoph, additional, Rammensee, Hans-Georg, additional, Singh-Jasuja, Harpreet, additional, Sahin, Ugur, additional, Dietrich, Pierre-Yves, additional, and Wick, Wolfgang, additional

Published
2018
Full Text
View/download PDF

11. Activated integrins identify functional antigen-specific CD8 + T cells within minutes after antigen stimulation

Author

Dimitrov, Stoyan, primary, Gouttefangeas, Cécile, additional, Besedovsky, Luciana, additional, Jensen, Anja T. R., additional, Chandran, P. Anoop, additional, Rusch, Elisa, additional, Businger, Ramona, additional, Schindler, Michael, additional, Lange, Tanja, additional, Born, Jan, additional, and Rammensee, Hans-Georg, additional

Published
2018
Full Text
View/download PDF

13. Activated integrins identify functional antigen-specific CD8+ T cells within minutes after antigen stimulation.

Author

Dimitrov, Stoyan, Gouttefangeasd, Cécile, Besedovsky, Luciana, Jensen, Anja T. R., Chandran, P. Anoop, Rusch, Elisa, Businger, Ramona, Schindler, Michael, Lange, Tanja, Born, Jan, and Rammensee, Hans-Georg

Subjects
T cells, CELL adhesion molecules, INTEGRINS, T cell receptors, ANTIGENS
Abstract

Immediate β2-integrin activation upon T cell receptor stimulation is critical for effective interaction between T cells and their targets and may therefore be used for the rapid identification and isolation of functional T cells. We present a simple and sensitive flow cytometry-based assay to assess antigen-specific T cells using fluorescent intercellular adhesion molecule (ICAM)-1 multimers that specifically bind to activated β2-integrins. The method is compatible with surface and intracellular staining; it is applicable for monitoring of a broad range of virus-, tumor-, and vaccine-specific CD8+ T cells, and for isolating viable antigen-reacting cells. ICAM-1 binding correlates with peptide-MHC multimer binding but, notably, it identifies the fraction of antigen-specific CD8+ T cells with immediate and high functional capability (i.e., expressing high levels of cytotoxic markers and cytokines). Compared with the currently available methods, staining of activated β2-integrins presents the unique advantage of requiring activation times of only several minutes, therefore delivering functional information nearly reflecting the in vivo situation. Hence, the ICAM-1 assay is most suitable for rapid and precise monitoring of functional antigen-specific T cell responses, including for patient samples in a variety of clinical settings, as well as for the isolation of functional T cells for adoptive cell-transfer immunotherapies. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

15. MOESM7 of A new synthetic toll-like receptor 1/2 ligand is an efficient adjuvant for peptide vaccination in a human volunteer

Author

Hans-Georg Rammensee, Karl-Heinz Wiesmüller, P. Chandran, Zelba, Henning, Rusch, Elisa, Gouttefangeas, Cécile, Kowalewski, Daniel, Marco, Moreno, Haen, Sebastian, Walz, Juliane, Yamel Gloria, Bödder, Johanna, Jill-Marie Schertel, Tunger, Antje, Müller, Luise, Kießler, Maximilian, Wehner, Rebekka, Schmitz, Marc, Jakobi, Meike, Schneiderhan-Marra, Nicole, Klein, Reinhild, Laske, Karoline, Artzner, Kerstin, Backert, Linus, Schuster, Heiko, Schwenck, Johannes, Weber, Alexander, Pichler, Bernd, Kneilling, Manfred, Fougère, Christian, Forchhammer, Stephan, Metzler, Gisela, Bauer, Jürgen, Weide, Benjamin, Schippert, Wilfried, Stevanović, Stefan, and Löffler, Markus

Subjects
3. Good health
Abstract

Additional file 7: Table S1. Induction of cytokine release by XS15. Table S2. Antibody responses to XS15.

16. MOESM7 of A new synthetic toll-like receptor 1/2 ligand is an efficient adjuvant for peptide vaccination in a human volunteer

Author

Hans-Georg Rammensee, Karl-Heinz Wiesmüller, P. Chandran, Zelba, Henning, Rusch, Elisa, Gouttefangeas, Cécile, Kowalewski, Daniel, Marco, Moreno, Haen, Sebastian, Walz, Juliane, Yamel Gloria, Bödder, Johanna, Jill-Marie Schertel, Tunger, Antje, Müller, Luise, Kießler, Maximilian, Wehner, Rebekka, Schmitz, Marc, Jakobi, Meike, Schneiderhan-Marra, Nicole, Klein, Reinhild, Laske, Karoline, Artzner, Kerstin, Backert, Linus, Schuster, Heiko, Schwenck, Johannes, Weber, Alexander, Pichler, Bernd, Kneilling, Manfred, Fougère, Christian, Forchhammer, Stephan, Metzler, Gisela, Bauer, Jürgen, Weide, Benjamin, Schippert, Wilfried, Stevanović, Stefan, and Löffler, Markus

Subjects
3. Good health
Abstract

Additional file 7: Table S1. Induction of cytokine release by XS15. Table S2. Antibody responses to XS15.

17. MOESM1 of A new synthetic toll-like receptor 1/2 ligand is an efficient adjuvant for peptide vaccination in a human volunteer

Author

Hans-Georg Rammensee, Karl-Heinz Wiesmüller, P. Chandran, Zelba, Henning, Rusch, Elisa, Gouttefangeas, Cécile, Kowalewski, Daniel, Marco, Moreno, Haen, Sebastian, Walz, Juliane, Yamel Gloria, Bödder, Johanna, Jill-Marie Schertel, Tunger, Antje, Müller, Luise, Kießler, Maximilian, Wehner, Rebekka, Schmitz, Marc, Jakobi, Meike, Schneiderhan-Marra, Nicole, Klein, Reinhild, Laske, Karoline, Artzner, Kerstin, Backert, Linus, Schuster, Heiko, Schwenck, Johannes, Weber, Alexander, Pichler, Bernd, Kneilling, Manfred, Fougère, Christian, Forchhammer, Stephan, Metzler, Gisela, Bauer, Jürgen, Weide, Benjamin, Schippert, Wilfried, Stevanović, Stefan, and Löffler, Markus

Subjects
3. Good health
Abstract

Additional file 1. Supplementary Materials and Methods.

18. MOESM8 of A new synthetic toll-like receptor 1/2 ligand is an efficient adjuvant for peptide vaccination in a human volunteer

Author

Hans-Georg Rammensee, Karl-Heinz Wiesmüller, P. Chandran, Zelba, Henning, Rusch, Elisa, Gouttefangeas, Cécile, Kowalewski, Daniel, Marco, Moreno, Haen, Sebastian, Walz, Juliane, Yamel Gloria, Bödder, Johanna, Jill-Marie Schertel, Tunger, Antje, Müller, Luise, Kießler, Maximilian, Wehner, Rebekka, Schmitz, Marc, Jakobi, Meike, Schneiderhan-Marra, Nicole, Klein, Reinhild, Laske, Karoline, Artzner, Kerstin, Backert, Linus, Schuster, Heiko, Schwenck, Johannes, Weber, Alexander, Pichler, Bernd, Kneilling, Manfred, Fougère, Christian, Forchhammer, Stephan, Metzler, Gisela, Bauer, Jürgen, Weide, Benjamin, Schippert, Wilfried, Stevanović, Stefan, and Löffler, Markus

Subjects
3. Good health
Abstract

Additional file 8: Fig. S1. Impact of XS15 on slanMo-mediated T-cell polarization. Fig. S2. Impact of XS15 on slanMo-mediated IFNγ expression by WT1 peptide-specific CD8+ T cells. Fig. S3. Ex vivo phenotype of granuloma infiltrating cells (GICs). Fig. S4. Ex vivo assessment of regulatory T cells (Treg) in granuloma infiltrating cells (GICs) and PBMCs. Fig. S5. Ex vivo phenotype of checkpoint receptors in granuloma infiltrating cells (GICs) and PBMCs. Fig. S6. Detection of vaccinated peptides in granuloma tissue by mass spectrometry.

19. MOESM8 of A new synthetic toll-like receptor 1/2 ligand is an efficient adjuvant for peptide vaccination in a human volunteer

Author

Hans-Georg Rammensee, Karl-Heinz Wiesmüller, P. Chandran, Zelba, Henning, Rusch, Elisa, Gouttefangeas, Cécile, Kowalewski, Daniel, Marco, Moreno, Haen, Sebastian, Walz, Juliane, Yamel Gloria, Bödder, Johanna, Jill-Marie Schertel, Tunger, Antje, Müller, Luise, Kießler, Maximilian, Wehner, Rebekka, Schmitz, Marc, Jakobi, Meike, Schneiderhan-Marra, Nicole, Klein, Reinhild, Laske, Karoline, Artzner, Kerstin, Backert, Linus, Schuster, Heiko, Schwenck, Johannes, Weber, Alexander, Pichler, Bernd, Kneilling, Manfred, Fougère, Christian, Forchhammer, Stephan, Metzler, Gisela, Bauer, Jürgen, Weide, Benjamin, Schippert, Wilfried, Stevanović, Stefan, and Löffler, Markus

Subjects
3. Good health
Abstract

Additional file 8: Fig. S1. Impact of XS15 on slanMo-mediated T-cell polarization. Fig. S2. Impact of XS15 on slanMo-mediated IFNγ expression by WT1 peptide-specific CD8+ T cells. Fig. S3. Ex vivo phenotype of granuloma infiltrating cells (GICs). Fig. S4. Ex vivo assessment of regulatory T cells (Treg) in granuloma infiltrating cells (GICs) and PBMCs. Fig. S5. Ex vivo phenotype of checkpoint receptors in granuloma infiltrating cells (GICs) and PBMCs. Fig. S6. Detection of vaccinated peptides in granuloma tissue by mass spectrometry.

20. MOESM1 of A new synthetic toll-like receptor 1/2 ligand is an efficient adjuvant for peptide vaccination in a human volunteer

Author

Hans-Georg Rammensee, Karl-Heinz Wiesmüller, P. Chandran, Zelba, Henning, Rusch, Elisa, Gouttefangeas, Cécile, Kowalewski, Daniel, Marco, Moreno, Haen, Sebastian, Walz, Juliane, Yamel Gloria, Bödder, Johanna, Jill-Marie Schertel, Tunger, Antje, Müller, Luise, Kießler, Maximilian, Wehner, Rebekka, Schmitz, Marc, Jakobi, Meike, Schneiderhan-Marra, Nicole, Klein, Reinhild, Laske, Karoline, Artzner, Kerstin, Backert, Linus, Schuster, Heiko, Schwenck, Johannes, Weber, Alexander, Pichler, Bernd, Kneilling, Manfred, Fougère, Christian, Forchhammer, Stephan, Metzler, Gisela, Bauer, Jürgen, Weide, Benjamin, Schippert, Wilfried, Stevanović, Stefan, and Löffler, Markus

Subjects
3. Good health
Abstract

Additional file 1. Supplementary Materials and Methods.

Catalog

Books, media, physical & digital resources
See catalog results