Author: "S. Mudaliar" - Searchworks@Jio Institute Digital Library Search Results

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200 results on '"S. Mudaliar"'

1. Hyper IGD syndrome: A case report

Author: Mohammed Naseer, P. Taur, A. Parmar, P. Kanvinde, S. Mudaliar, N. Dighe, P. Keni, A. Pandrowala, M. Madkaikar, A. Dalvi, A. Mishra, B. Agarwal, Y. Amdekar, and M. Desai
Subjects: Pediatrics, RJ1-570
Published: 2016
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2. An interesting case of fever-neonatal onset multi systemic inflammatory disorder

Author: Mohammed Naseer, P. Taur, A. Parmar, P. Kanvinde, A. Hedge, M. Madkaikar, R.G. Mansky, S. Mudaliar, A. Swami, N. Shah, B. Agarwal, and M. Desai
Subjects: Pediatrics, RJ1-570
Published: 2016
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3. Retinoblastoma with and without Extraocular Tumor Extension

Author: Swathi Kaliki, MD, Vijitha S. Vempuluru, MD, Ido Didi Fabian, MD, Elhassan Abdallah, MD, Shehu U. Abdullahi, MD, Rula A. Abdulqader, MD, Aminatu A. Abdulrahaman, MD, Sherif Abouelnaga, MD, Dupe S. Ademola-Popoola, FMCOph, FWACS, Adedayo Adio, FWACS, Mahmoud A. Afifi, MD, Armin R. Afshar, MD, Priyanka Aggarwal, MD, Ada E. Aghaji, FMCOph MSc, Alia Ahmad, MRCPCH UK, Marliyanti N.R. Akib, MD, Adeseye M. Akinsete, MBBS, Lamis Al Harby, MD, Saleh A. Al Mesfer, MD, Mouroge H. Al Ani, MD, Silvia Alarcón Portabella, MD, Safaa A.F. Al-Badri, MD, Ana Patricia A. Alcasabas, MD, Saad A. Al-Dahmash, MD, Amanda Alejos, MD, Ernesto Alemany-Rubio, MD, Amadou I. Alfa Bio, MD, Yvania Alfonso Carreras, MD, Christiane E. Al-Haddad, MD, Hamoud H.Y. Al-Hussaini, MD, MSc, Amany M. Ali, MD, Donjeta B. Alia, MD, Mazin F. Al-Jadiry, MD, Usama Al-Jumaly, MD, Hind M. Alkatan, MD, Charlotta All-Eriksson, MD, PhD, Ali A.R.M. Al-Mafrachi, FIBMS, Argentino A. Almeida, MD, Khalifa M. Alsawidi, MD, Athar A.S.M. Al-Shaheen, MD, Entissar H. Al-Shammary, MD, Doreen Amankwaa-Frempong, MBChB, Primawita O. Amiruddin, MD, Inggar Armytasari, MD, Nicholas J. Astbury, FRCS, FRCOphth, Hatice T. Atalay, MD, Eda Ataseven, MD, La-ongsri Atchaneeyasakul, MD, Rose Atsiaya, OCO, Rudolf Autrata, MD, PhD, Julia Balaguer, MD, PhD, Ruhengiz Balayeva, PhD, Honorio Barranco, MD, PhD, Paulina Bartoszek, MD, Katarina Bartuma, MD, PhD, Covadonga Bascaran, MD, MSc, Nikolaos E. Bechrakis, MD, Maja Beck Popovic, MD, Ainura S. Begimkulova, MD, Sarra Benmiloud, MD, Rokia C. Berete, MD, PhD, Jesse L. Berry, MD, Anirban Bhaduri, MD, Sunil Bhat, MBBS, MD, Arpita Bhattacharyya, MD, Eva M. Biewald, MD, Elaine Binkley, MD, Sharon Blum, MD, Nadia Bobrova, MD, H. Culver Boldt, MD, Maria Teresa B.C. Bonanomi, MD, PhD, Gabrielle C. Bouda, MD, Hédi Bouguila, MD, PhD, Rachel C. Brennan, MD, Bénédicte G. Brichard, MD, PhD, Jassada Buaboonnam, MD, Aléine Budiongo, MD, Matthew Burton, FRCOphth, Patricia Calderón-Sotelo, MD, Doris A. Calle Jara, MD, Jayne E. Camuglia, FRANZCO, Miriam R. Cano, MD, MSc, Michael Capra, FRCPI, Shani Caspi, MD, Nathalie Cassoux, MD, PhD, Guilherme Castela, MD, Luis Castillo, MD, Jaume Català-Mora, MD, PhD, Isabel Caviedes, MD, Arthika Chandramohan, MD, Guillermo L. Chantada, MD, PhD, Shabana Chaudhry, MD, Bhavna Chawla, MD, Wensi Chen, MD, Faraja S. Chiwanga, MSc, Tsengelmaa Chuluunbat, MD, PhD, Krzysztof Cieslik, MD, Antony Clark, FRANZCO, Ruellyn L. Cockcroft, MB ChB , M Med Paed, Codruta Comsa, MD, Maria G. Correa Llano, MD, Timothy W. Corson, PhD, Line Couitchere, MD, Kristin E. Cowan-Lyn, MD, MBBS, Monika Csóka, MD, PhD, Wantanee Dangboon, MD, Anirban Das, MD, Pranab Das, MD, Sima Das, MS, Jacquelyn M. Davanzo, BSN, BSPH, Alan Davidson, MBChB, MPhil, Sonia De Francesco, MD, Patrick De Potter, MD, PhD, Karina Q. Delgado, MD, PhD, Hakan Demirci, MD, Laurence Desjardins, MD, Rosdali Y. Diaz Coronado, MD, Helen Dimaras, PhD, Andrew J. Dodgshun, M Phil, Carla R. Donato Macedo, MD, Monica D. Dragomir, MD, PhD, Yi Du, MD, Magritha Du Bruyn, MD, Johannes P. Du Plessis, MMed (Paed), Gagan Dudeja, MBBS, MS, Katrin Eerme, MD, I Wayan Eka Sutyawan, MD, Asmaa El Kettani, MD, Amal M. Elbahi, MD, James E. Elder, MBBS, Alaa M. Elhaddad, MD, PhD, Moawia M.A. Elhassan, MD, Mahmoud M. Elzembely, MD, Connor Ericksen, MD, Vera A. Essuman, FWACS, Ted Grimbert A. Evina, MD, Ifeoma R. Ezegwui, FMCOph, FWACS, FAEH, Zehra Fadoo, MBBS, Adriana C. Fandiño, MD, Mohammad Faranoush, MD, Oluyemi Fasina, FWACS, Delia D.P.G. Fernández, MSc, Ana Fernández-Teijeiro, MD, PhD, Allen Foster, FRCOphth, Shahar Frenkel, MD, PhD, Ligia D. Fu, MD, Soad L. Fuentes-Alabi, MD, MPH, Juan L. Garcia, MSc, David García Aldana, MD, Henry N. Garcia Pacheco, MD, Jennifer A. Geel, MBChB, MMed, Fariba Ghassemi, MD, Ana V. Girón, MD, Marco A. Goenz, MD, Aaron S. Gold, OD, Hila Golberg, MD, Glen A. Gole, MD, FRANZCO, Nir Gomel, MD, Efren Gonzalez, MD, Graciela Gonzalez Perez, MD, Liudmira González-Rodríguez, MD, Malka Gorfine, PhD, Jaime Graells, MD, Pernille A. Gregersen, MD, Nathalia D.A.K. Grigorovski, MD, Koffi M. Guedenon, MD, D Sanjeeva Gunasekera, MD, Ahmet K. Gündüz, MD, Himika Gupta, MD, Sanjiv Gupta, MS, Vineeta Gupta, MD, Theodora Hadjistilianou, MD, Patrick Hamel, MD, Syed A. Hamid, FCPS, Norhafizah Hamzah, MSc, Eric D. Hansen, MD, J William Harbour, MD, M. Elizabeth Hartnett, MD, Murat Hasanreisoglu, MD, Sadiq Hassan, MD, FWACS, Shadab Hassan, FRCS, FCPS, Wojciech Hautz, MD, Huda A. Haydar, CHD, Stanislava Hederova, MD, Laila Hessissen, MD, Hoby Lalaina, MD, Suradej Hongeng, MD, Diriba F. Hordofa, MD, G. Baker Hubbard, MD, Marlies Hummlen, MD, Kristina Husakova, MD, Allawi N. Hussein Al-Janabi, MD, Affiong A. Ibanga, MB.BCh, FMCOph, Russo Ida, MD, Vesna R. Ilic, MD, Ziyavuddin Islamov, MD, Vivekaraj Jairaj, DNB, Teyyeb A. Janjua, MD, FCPS, FRCSEd, Irfan Jeeva, FRCOphth, Xunda Ji, MD, Dong Hyun Jo, MD, PhD, Michael M. Jones, MD, PhD, FRANZCO, Theophile B. Amani Kabesha, MD, PhD, Rolande L. Kabore, MD, Abubakar Kalinaki, MD, Pius Kamsang, MD, Mehmet Kantar, MD, Noa Kapelushnik, MD, Tamar Kardava, PhD, Rejin Kebudi, MD, Jonny Keomisy, MD, Tomas Kepak, MD, Petra Ketteler, MD, Zohora J. Khan, MD, Hussain A. Khaqan, MD, Vikas Khetan, FRCS, FACS, Alireza Khodabande, MD, Zaza Khotenashvili, MD, Jonathan W. Kim, MD, Jeong Hun Kim, MD, PhD, Hayyam Kiratli, MD, Tero T. Kivelä, MD, Artur Klett, MD, PhD, Irem Koç, MD, Jess Elio Kosh Komba Palet, MD, Dalia Krivaitiene, MD, PhD, Mariana Kruger, Mmed Paed, PhD, Kittisak Kulvichit, MD, Mayasari W. Kuntorini, MD, Alice Kyara, BA, Geoffrey C. Lam, FRANZCO, Scott A. Larson, MD, Slobodanka Latinović, MD, PhD, Kelly D. Laurenti, MD, Yotam Lavi, MD, PhD, Alenka Lavric Groznik, MD, Amy A. Leverant, MD, Cairui Li, MD, Kaijun Li, MD, Ben Limbu, MD, Chun-Hsiu Liu, MD, Quah Boon Long, FRCS (Ed), MMed ( Ophth), FAMS, Juan P. López, MD, Robert M. Lukamba, MD, Sandra Luna-Fineman, MD, Delfitri Lutfi, MD, Lesia Lysytsia, MD, Shiran Madgar, MD, George N. Magrath, MD, Amita Mahajan, MD, Puja Maitra, MD, Erika Maka, MD, Emil K. Makimbetov, MD, Azza M.Y. Maktabi, MD, Carlos Maldonado, MD, Ashwin Mallipatna, MD, Rebecca Manudhane, MD, Lyazat Manzhuova, MD, Nieves Martín Begue, MD, PhD, Sidra Masud, MBBS, Ibrahim O. Matende, MD, M. Med (Oph), Clarissa C.D.S. Mattosinho, MD, Marchelo Matua, BAPH, Ismail Mayet, MD, Freddy B. Mbumba, MD, MMed Paed, John D. McKenzie, MD, Azim Mehrvar, MD, Aemero A. Mengesha, MD, Vikas Menon, MD, Gary John V.D.D. Mercado, MD, Marilyn B. Mets, MD, Edoardo Midena, MD, PhD, Audra Miller, MD, Divyansh K.C. Mishra, DNB, Furahini G. Mndeme, MD, Ahmed A. Mohamedani, FRCPath, Mona T. Mohammad, MD, FRCS, Annette C. Moll, MD, PhD, Margarita M. Montero, MD, Claude Moreira, MD, PhD, Prithvi Mruthyunjaya, MD, MHS, Mchikirwa S. Msina, MMed Ophth, Gerald Msukwa, MMed Ophth, Sangeeta S. Mudaliar, DNB Pediatric, Hassan Muhammad, MD, Kangwa I. Muma, MMed Ophth, FCOphth, Francis L. Munier, MD, Timothy G. Murray, MD, MBA, Kareem O. Musa, FWACS, FMCOphth, FICO, Asma Mushtaq, MD, Anne A. Musika, MD, Hamzah Mustak, MD, Tajudeen Mustapha, MBBS, FWACS, Okwen M. Muyen, MD, Khumo H. Myezo, Msc, Gita Naidu, MMed Paed, PhD, Natasha Naidu, MBCHB, FCS Ophthalmol, Akshay Gopinathan Nair, MD, Sundaram Natarajan, FRCS, Larisa Naumenko, MD, PhD, Paule Aïda Ndoye Roth, MD PhD, Yetty M. Nency, MD, Vladimir Neroev, MD, PhD, Yvonne Ng, MBChB ( Auckland) , FRANZCO, Marina Nikitovic, MD, PhD, Elizabeth D. Nkanga, FMCOph, Henry E. Nkumbe, MD, Marcel N. Numbi, MD, Kalle Nummi, MD, Murtuza Nuruddin, FRCS, Mutale Nyaywa, MD, MMed Ophth, FCOphth, Chinsisi Nyirenda, MD, Ghislaine Obono-Obiang, MD, Scott C.N. Oliver, MD, Joaquin Ooporto, MD, Miriam Ortega-Hernández, MD, Alexander Oscar, MD, Diego Ossandon, MD, Halimah Pagarra, MD, PhD, Vivian Paintsil, FWACP, Luisa Paiva, MD, Mahesh Shanmugam Palanivelu, FRCSED, Ruzanna Papyan, MD, Raffaele Parrozzani, MD, PhD, Claudia R. Pascual Morales, MD, Katherine E. Paton, MD, FRCSC, Jacob Pe'er, MD, Jesús Peralta Calvo, MD, Sanja Perić, MD, PhD, Chau T.M. Pham, MD, Remezo Philbert, MD, David A. Plager, MD, Pavel Pochop, MD, PhD, Rodrigo A. Polania, MD, Vladimir Polyakov, MD, Jimena Ponce, MD, Ali O. Qadir, MD, Seema Qayyum, FCPS, Jiang Qian, MD, Ardizal Rahman, MD, Purnima Rajkarnikar, MD, Rajesh Ramanjulu, MD, Aparna Ramasubramanian, MD, Marco A. Ramirez-Ortiz, MD, MPH, Jasmeen K. Randhawa, BA, Léa Raobela, MD, Riffat Rashid, MS, M. Ashwin Reddy, FRCOphth, Lorna A. Renner, FRCPCH (UK), David Reynders, MD, Dahiru Ribadu, FMCOph, Petra Ritter-Sovinz, MD, Anna Rogowska, MD, Duangnate Rojanaporn, MD, Livia Romero, MD, Soma R. Roy, DCO, Raya H. Saab, MD, Svetlana Saakyan, MD, PhD, Ahmed H. Sabhan, MD, Mandeep S. Sagoo, FRCS (Ed), Azza M.A. Said, MD, Rohit Saiju, MD, Beatriz Salas, MD, Sonsoles San Román Pacheco, MD, Gissela L. Sánchez, MD, Alma Janeth Sanchez Orozco, MD, Phayvanh Sayalith, MD, Trish A. Scanlan, MRCPI, MSc, Christoph Schwab, MD, Ahad Sedaghat, MD, Rachna Seth, DNB MNAMS, Mariana Sgroi, MD, Ankoor S. Shah, MD, PhD, Shawkat A. Shakoor, MS, Manoj K. Sharma, MD, Sadik T. Sherief, MD, Carol L. Shields, MD, David Sia, MB ChB, FRANZCO, Sorath Noorani Siddiqui, MD, Sidi Sidi cheikh, MD, PhD, Sónia Silva, MD, Arun D. Singh, MD, Usha Singh, MS, Penny Singha, MD, Rita S. Sitorus, MD, PhD, Alison H. Skalet, MD, PhD, Hendrian D. Soebagjo, MD, PhD, Tetyana Sorochynska, MD, PhD, Grace Ssali, MD, Andrew W. Stacey, MD, Sandra E. Staffieri, PhD, Erin D. Stahl, MD, David M. Steinberg, PhD, David K. Stones, MBChB, FCPaed, Caron Strahlendorf, MD, Maria Estela Coleoni Suarez, MD, Sadia Sultana, FCPS, Xiantao Sun, MD, Rosanne Superstein, MD, Eddy Supriyadi, MD, PhD, Supawan Surukrattanaskul, MD, Shigenobu Suzuki, MD, PhD, Karel Svojgr, MD, PhD, Fatoumata Sylla, MD, Gevorg Tamamyan, MD, PhD, Deborah Tan, MBBS, Alketa Tandili, MD, PhD, Jing Tang, MD, Fanny F. Tarrillo Leiva, MD, Maryam Tashvighi, MD, Bekim Tateshi, MD, PhD, Kok Hoi Teh, MD, Edi S. Tehuteru, MD, Luiz F. Teixeira, MD, Manca Tekavcic Pompe, MD, PhD, Abdullah Dahan M. Thawaba, MD, Tuyisabe Theophile, MSc, Helen Toledano, MBChB, Doan L. Trang, MD, Fousseyni Traoré, MD, Devjyoti Tripathy, MD, Samuray Tuncer, MD, Harba Tyau-Tyau, MD, Ali B. Umar, MD, FMCPath, Emel Unal, MD, Ogul E. Uner, BA, Steen F. Urbak, MD, PhD, Tatiana L. Ushakova, MD, Rustam H. Usmanov, MD, Sandra Valeina, MD, Paola Valente, MD, Milo van Hoefen Wijsard, MD, Jacqueline Karina Vasquez Anchaya, MD, Leon O. Vaughan, FRCS (Ed), Nevyana V. Veleva-Krasteva, MD, PhD, Nishant Verma, MD, Andi A. Victor, MD, PhD, Maris Viksnins, MD, Edwin G. Villacís Chafla, MD, Victor M. Villegas, MD, Victoria Vishnevskia-Dai, MD, Keith Waddell, DM, FRCP, FRCS, FRCOphth, Amina H. Wali, MD, FMCOph Nigeria, Yi-Zhuo Wang, MD, Nutsuchar Wangtiraumnuay, MD, FICO, Julie A. Wetter, MMed Rad Onc, FCRad Onc, Widiarti P. Riono, MD, Matthew W. Wilson, MD, Amelia D.C. Wime, MD, Atchareeya Wiwatwongwana, MD, Damrong Wiwatwongwana, MD, Charlotte Wolley Dod, MD, Emily S. Wong, FCOphth HK, FHKAM, Phanthipha Wongwai, MD, PhD, Si-qi Wu, MSc, Daoman Xiang, MD, PhD, Yishuang Xiao, MSc, Bing Xu, MD, Kang Xue, MD, Antonio Yaghy, MD, Jason C. Yam, FRCSEd, Huasheng Yang, MD, Jenny M. Yanga, MD, Muhammad A. Yaqub, MD, FCPS, FRCSEd, Vera A. Yarovaya, MD, Andrey A. Yarovoy, MD, PhD, Huijing Ye, MD, Roberto I. Yee, MD, Yacoub A. Yousef, MD, Putu Yuliawati, MD, Arturo M. López, MD, Ekhtelbenina Zein, MD, Yi Zhang, MD, PhD, Katsiaryna Zhilyaeva, MD, Nida Zia, MBBS, MCPS, Othman A.O. Ziko, MD, PhD, Marcia Zondervan, MBA, Sabrina Schlüter, MD, and Richard Bowman, FRCOphth
Subjects: External beam radiotherapy, Extraocular extension, Multimodal treatment, Retinoblastoma, Tumor, Ophthalmology, RE1-994
Abstract: Purpose: To study the treatment and outcomes of children with retinoblastoma (RB) with extraocular tumor extension (RB-EOE) and compare them with RB without extraocular tumor extension (RB-w/o-EOE). Design: Multicenter intercontinental collaborative prospective study from 2017 to 2020. RB-EOE cases included those with overt orbital tumor extension in treatment-naive patients. Cases with microscopic orbital extension detected postenucleation were excluded from the study. Participants: A total of 319 children with RB-EOE and 3116 children with RB-w/o-EOE. Intervention: Chemotherapy, enucleation, exenteration, radiotherapy. Main Outcome Measures: Systemic metastasis and death. Results: Of the 3435 RB patients included in this study, 309 (9%) were from low-income countries (LIC), 1448 (42%) from lower-middle income, 1012 (29%) from upper-middle income, and 666 (19%) patients from high-income countries. There was an inverse relationship between the percentage of RB-EOE and national income level, with 96 (31%) patients from LIC, 197 (6%) lower-middle income, 20 (2%) upper-middle income, and 6 (1%) patients from high-income countries (P = 0.0001). The outcomes were statistically significant for RB-EOE compared with RB-w/o-EOE: systemic metastasis (32% vs. 4% respectively; P = 0.0001) and metastasis-related death (63% vs. 6% respectively; P = 0.0001). Multimodal treatment was the most common form of treatment (n = 177; 54%) for RB-EOE, with most cases undergoing a combination of intravenous chemotherapy and enucleation (n = 97; 30%). Adjuvant external beam radiotherapy (EBRT) after surgery (enucleation/orbital exenteration) was given in only 68 (21%) cases. Kaplan–Meier analysis for systemic metastasis and metastasis-related death in RB-EOE was 28% and 57% at 1 year, 29% and 60% at 2 years, and 29% and 61% at 3 years, respectively. Cox regression analysis revealed that the risk of death from RB-EOE was greater in patients aged >4 years than
Published: 2025
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4. Higher burden of cardiometabolic and socioeconomic risk factors in women with type 2 diabetes: an analysis of the Glycemic Reduction Approaches in Diabetes (GRADE) baseline cohort

Author: C Wright, C Sanders, C Wilson, L Tucker, S Jones, S Douglass, C Patel, A Kumar, S Smith, A Ghosh, C Adams, R Hill, D Martin, J Hu, M Lee, N Patel, O Smith, J Cook, J Day, M Jackson, G Riera, P McGee, J Park, J Jiménez, S Yang, A Carlson, C Martin, H Liu, Y Li, A Krol, K Wright, S Golden, A Sood, J Martinez, D Sanchez, K Burton, Y Gao, S Martin, O Sanchez, C DeSouza, M Johnson, L Estrada, A Jackson, J Higgins, K Martin, J Craig, A Kuhn, L Ngo, Deborah J Wexler, R Chatterjee, E Walker, J Kerr, W Taylor, J Lim, M Perez, R Henry, Vanita R Aroda, R Fraser, Cyrus Desouza, E King, C Campbell, J González, E Diaz, P Zhang, J Marks, S Abraham, A Ross, M Khalid, T Young, J Myers, J Barzilay, B Chambers, G Montes, C Jensen, J McConnell, R Nelson, L Prosser, S Morton, M Curtis, P Wilson, L Young, M Fürst, S Warren, C Newman, S Kuo, N Rasouli, A Werner, L Morton, A Ghazi, M Salam, F Ismail-Beigi, P Kringas, C Baker, E Ellis, A Cherian, L Holloway, M Madden, B Hollis, G Fuller, B Steiner, K Stokes, R Ayala, T Lowe, K Chu, S Durán, D Dyer, A Alfred, J Leger, Nicole M Butera, T Hamilton, J Costello, E Burgess, R Garg, A Maxwell, C Stevens, W Ye, T Tran, L Fischer, M Hurtado, H Schneier, C Lund, R Lorch, M Mullen, J Bantle, K Arnold, D Wexler, A TURCHIN, MS Lee, D Howard, J Tejada, S Hernandez, Tasma Harindhanavudhi, E Schroeder, K Pham, S Kunkel, A Fagan, G Lord, H CHONG, A Smiley, E Debnam, H Petrovitch, M Bäckman, B Kauffman, V Jenkins, B Cramer, JP Crandall, MD McKee, S Behringer-Massera, J Brown-Friday, E Xhori, K Ballentine-Cargill, H Estrella, S Gonzalez de la torre, J Lukin, LS Phillips, D Olson, M Rhee, TS Raines, J Boers, C Gullett, M Maher-Albertelli, R Mungara, L Savoye, CA White, F Morehead, S Person, M Sibymon, S Tanukonda, A Balasubramanyam, R Gaba, P Hollander, E Roe, P Burt, K Chionh, C Falck-Ytter, L Sayyed Kassem, M Tiktin, T Kulow, KA Stancil, J Iacoboni, MV Kononets, L Colosimo, R Goland, J Pring, L Alfano, C Hausheer, K Gumpel, A Kirpitch, JB Green, H AbouAssi, MN Feinglos, J English Jones, RP Zimmer, BM Satterwhite, K Evans Kreider, CR Thacker, CN Mariash, KJ Mather, A Lteif, V Pirics, D Aguillar, S Hurt, R Bergenstal, T Martens, J Hyatt, H Willis, W Konerza, K Kleeberger, R Passi, S Fortmann, M Herson, K Mularski, H Glauber, J Prihoda, B Ash, C Carlson, PA Ramey, E Schield, B Torgrimson-Ojerio, E Panos, S Sahnow, K Bays, K Berame, D Ghioni, J Gluth, K Schell, J Criscola, C Friason, S Nazarov, N Rassouli, R Puttnam, B Ojoawo, C Sanders-Jones, Z El-Haqq, A Kolli, J Meigs, A Dushkin, G Rocchio, M Yepes, H Dulin, M Cayford, A DeManbey, M Hillard, N Thangthaeng, L Gurry, R Kochis, E Raymond, V Ripley, V Aroda, A Loveland, M Hamm, HJ Florez, WM Valencia, S Casula, L Oropesa-Gonzalez, L Hue, AK Riccio Veliz, R Nieto-Martinez, M Gutt, A Ahmann, D Aby-Daniel, F Joarder, V Morimoto, C Sprague, D Yamashita, N Cady, N Rivera-Eschright, P Kirchhoff, B Morales Gomez, J Adducci, A Goncharova, SH Hox, M Matwichyna, NO Bermudez, L Broadwater, RR Ishii, DS Hsia, WT Cefalu, FL Greenway, C Waguespack, N Haynes, A Thomassie, B Bourgeois, C Hazlett, S Mudaliar, S Boeder, J Pettus, D Garcia-Acosta, S Maggs, C DeLue, E Castro, J Krakoff, JM Curtis, T Killean, E Joshevama, K Tsingine, T Karshner, J Albu, FX Pi-Sunyer, S Frances, C Maggio, J Bastawrose, X Gong, MA Banerji, D Lorber, NM Brown, DH Josephson, LL Thomas, M Tsovian, MH Jacobson, MM Mishko, MS Kirkman, JB Buse, J Dostou, K Bergamo, A Goley, JF Largay, S Guarda, J Cuffee, D Culmer, H Almeida, S Coffer, L Kiker, K Josey, WT Garvey, A Agne, S McCullars, RM Cohen, MC Rogge, K Kersey, S Lipp, MB Vonder Meulen, C Underkofler, S Steiner, E Cline, WH Herman, R Pop-Busui, MH Tan, A Waltje, A Katona, L Goodhall, R Eggleston, K Whitley, S Bule, N Kessler, E LaSalle, ER Seaquist, A Bantle, T Harindhanavudhi, B Redmon, M Coe, M Mech, A Taddese, L Lesne, L Kuechenmeister, V Shivaswamy, AL Morales, K Seipel, J Eggert, R Tillson, DS Schade, A Adolphe, M Burge, E Duran-Valdez, P August, MG Rodriguez, O Griffith, A Naik, Barbara I Gulanski, Heidi Krause-Steinrauf, Judith H Lichtman, Jennifer B Green, Colleen E Suratt, Hiba AbouAssi, Andrew J Ahmann, E Gonzalez Hattery, A Ideozu, G McPhee, SA Khan, JB Kimpel, HM Ismail, ME Larkin, M Magee, A Ressing, L Manandhar, F Mwicigi, V Lagari-Libhaber, A Cuadot, YJ Kendal, B Veciana, G Fry, A Dragg, B Gildersleeve, J Arceneaux, M Pavlionis, A Stallings, S Machineni, AL Cherrington, MCR Lawson, C Adkins, T Onadeko, M Razzaghi, C Lyon, R Penaloza, WI Sivitz, LK Knosp, S Bojescu, S Burbach, A Bancroft, FA Jamaleddin Ahmad, D Hernandez McGinnis, B Pucchetti, E Scripsick, A Zamorano, RA DeFronzo, E Cersosimo, M Abdul-Ghani, C Triplitt, D Juarez, RI Garza, H Verastiqui, C Puckett, P Raskin, C Rhee, LF Jordan, S Sao, L Osornio Walker, L Schnurr-Breen, RB Kreymer, D Sturgess, KM Utzschneider, SE Kahn, L Alarcon-Casas Wright, EJ Boyko, EC Tsai, DL Trence, S Trikudanathan, BN Fattaleh, BK Montgomery, KM Atkinson, A Kozedub, T Concepcion, C Moak, N Prikhodko, S Rhothisen, TA Elasy, L Shackelford, R Goidel, N Hinkle, C Lovell, J Lipps Hogan, JB McGill, T Schweiger, S Kissel, C Recklein, MJ Clifton, W Tamborlane, A Camp, B Gulanski, SE Inzucchi, M Alguard, P Gatcomb, K Lessard, L Iannone, A Montosa, E Magenheimer, J Fradkin, HB Burch, AA Bremer, DM Nathan, JM Lachin, H Krause-Steinrauf, N Younes, I Bebu, N Butera, CJ Buys, MR Gramzinski, SD Hall, E Kazemi, E Legowski, C Suratt, M Tripputi, A Arey, J Bethepu, P Mangat Dhaliwal, E Mesimer, M Steffes, J Seegmiller, A Saenger, V Arends, D Gabrielson, T Conner, J Huminik, A Scrymgeour, EZ Soliman, Y Pokharel, ZM Zhang, L Keasler, S Hensley, R Mihalcea, DJ Min, V Perez-Rosas, K Resnicow, H Shao, J Luchsinger, S Assuras, E Groessl, F Sakha, N Hillery, BM Everett, I Abdouch, G Bahtiyar, P Brantley, FE Broyles, G Canaris, P Copeland, JJ Craine, WL Fein, A Gliwa, L Hope, R Meiners, V Meiners, H O’Neal, JE Park, A Sacerdote, E Sledge, L Soni, J Steppel-Reznik, B Brooks-Worrell, CS Hampe, JP Palmer, A Shojaie, L Doner Lotenberg, JM Gallivan, and DM Tuncer
Subjects: Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract: Introduction Type 2 diabetes mellitus (T2DM) is a powerful risk factor for cardiovascular disease (CVD), conferring a greater relative risk in women than men. We sought to examine sex differences in cardiometabolic risk factors and management in the contemporary cohort represented by the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE).Research design and methods GRADE enrolled 5047 participants (1837 women, 3210 men) with T2DM on metformin monotherapy at baseline. The current report is a cross-sectional analysis of baseline data collected July 2013 to August 2017.Results Compared with men, women had a higher mean body mass index (BMI), greater prevalence of severe obesity (BMI≥40 kg/m2), higher mean LDL cholesterol, greater prevalence of low HDL cholesterol, and were less likely to receive statin treatment and achieve target LDL, with a generally greater prevalence of these risk factors in younger women. Women with hypertension were equally likely to achieve blood pressure targets as men; however, women were less likely to receive ACE inhibitors or angiotensin receptor blockers. Women were more likely to be divorced, separated or widowed, and had fewer years of education and lower incomes.Conclusions This contemporary cohort demonstrates that women with T2DM continue to have a greater burden of cardiometabolic and socioeconomic risk factors than men, particularly younger women. Attention to these persisting disparities is needed to reduce the burden of CVD in women.Trial registration number ClinicalTrials.gov (NCT01794143)
Published: 2023
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5. Shape of the OGTT glucose response curve: relationship with β-cell function and differences by sex, race, and BMI in adults with early type 2 diabetes treated with metformin

Author: C Wright, C Wilson, L Tucker, S Jones, S Douglass, C Patel, A Kumar, S Smith, C Adams, R Hill, D Martin, M Lee, N Patel, J Cook, M Jackson, G Riera, E González, J Park, S Yang, A Carlson, C Martin, A Krol, A Sood, J Martinez, C DeSouza, M Johnson, L Estrada, A Jackson, K Martin, SA Khan, J Craig, A Kuhn, Deborah J Wexler, R Chatterjee, J Kerr, W Taylor, R Henry, R Fraser, Kieren J Mather, M Larkin, E King, E Diaz, J Marks, A Ross, M Khalid, J Barzilay, B Chambers, G Montes, C Jensen, J McConnell, R Nelson, S Morton, M Curtis, P Wilson, L Young, M Fürst, C Newman, S Kuo, N Rasouli, A Werner, A Ghazi, F Ismail-Beigi, P Kringas, C Baker, E Ellis, Philip Raskin, A Cherian, L Holloway, M Madden, B Hollis, G Fuller, B Steiner, K Stokes, T Lowe, K Chu, S Durán, A Alfred, John M Lachin, T Hamilton, J Costello, E Burgess, R Garg, C Stevens, T Tran, M Hurtado, H Schneier, R Lorch, M Mullen, J Bantle, K Arnold, D Wexler, Neda Rasouli, D Howard, J Tejada, S Hernandez, E Schroeder, S Kunkel, G Lord, A Smiley, E Debnam, H Petrovitch, B Kauffman, V Jenkins, B Cramer, Kristina M Utzschneider, Naji Younes, Joshua I Barzilay, Mary Ann Banerji, Robert M Cohen, Erica V Gonzalez, Faramarz Ismail-Beigi, Steven E Kahn, JP Crandall, MD McKee, S Behringer-Massera, J Brown-Friday, E Xhori, K Ballentine-Cargill, H Estrella, S Gonzalez de la torre, J Lukin, LS Phillips, D Olson, M Rhee, TS Raines, J Boers, C Gullett, M Maher-Albertelli, R Mungara, L Savoye, CA White, F Morehead, S Person, M Sibymon, S Tanukonda, A Balasubramanyam, R Gaba, P Hollander, E Roe, P Burt, K Chionh, C Falck-Ytter, L Sayyed Kassem, M Tiktin, T Kulow, KA Stancil, J Iacoboni, MV Kononets, G McPhee AMaxwell, L Colosimo, R Goland, J Pring, L Alfano, C Hausheer, K Gumpel, A Kirpitch, JB Green, H AbouAssi, MN Feinglos, J English Jones, RP Zimmer, BM Satterwhite, K Evans Kreider, CR Thacker, CN Mariash, KJ Mather, A Lteif, V Pirics, D Aguillar, S Hurt, R Bergenstal, T Martens, J Hyatt, H Willis, W Konerza, K Kleeberger, R Passi, S Fortmann, M Herson, K Mularski, H Glauber, J Prihoda, B Ash, C Carlson, PA Ramey, E Schield, B Torgrimson-Ojerio, E Panos, S Sahnow, K Bays, K Berame, D Ghioni, J Gluth, K Schell, J Criscola, C Friason, S Nazarov, N Rassouli, R Puttnam, B Ojoawo, C Sanders-Jones, Z El-Haqq, A Kolli, J Meigs, A Dushkin, G Rocchio, M Yepes, H Dulin, M Cayford, A DeManbey, M Hillard, N Thangthaeng, L Gurry, R Kochis, E Raymond, V Ripley, V Aroda, Ann Ressing, A Loveland, M Hamm, F Mofor, HJ Florez, WM Valencia, S Casula, L Oropesa-Gonzalez, L Hue, AK Riccio Veliz, R Nieto-Martinez, M Gutt, A Ahmann, D Aby-Daniel, F Joarder, V Morimoto, C Sprague, D Yamashita, N Cady, N Rivera-Eschright, P Kirchhoff, B Morales Gomez, J Adducci, A Goncharova, SH Hox, M Matwichyna, NO Bermudez, L Broadwater, RR Ishii, DS Hsia, WT Cefalu, FL Greenway, C Waguespack, N Haynes, A Thomassie, B Bourgeois, C Hazlett, S Mudaliar, S Boeder, J Pettus, D Garcia-Acosta, S Maggs, C DeLue, E Castro, J Krakoff, JM Curtis, T Killean, E Joshevama, K Tsingine, T Karshner, J Albu, FX Pi-Sunyer, S Frances, C Maggio, J Bastawrose, X Gong, MA Banerji, D Lorber, NM Brown, DH Josephson, LL Thomas, M Tsovian, MH Jacobson, MM Mishko, MS Kirkman, JB Buse, J Dostou, K Bergamo, A Goley, JF Largay, S Guarda, J Cuffee, D Culmer, H Almeida, S Coffer, L Kiker, K Josey, WT Garvey, A Cherrington, D Golson, MC Robertson, A Agne, S McCullars, RM Cohen, MC Rogge, K Kersey, S Lipp, MB Vonder Meulen, C Underkofler, S Steiner, W Sivitz, E Cline, L Knosp, WH Herman, R Pop-Busui, MH Tan, A Waltje, A Katona, L Goodhall, R Eggleston, K Whitley, S Bule, N Kessler, E LaSalle, ER Seaquist, A Bantle, T Harindhanavudhi, B Redmon, M Coe, M Mech, A Taddese, L Lesne, L Kuechenmeister, V Shivaswamy, AL Morales, K Seipel, J Eggert, R Tillson, DS Schade, A Adolphe, M Burge, E Duran-Valdez, P August, MG Rodriguez, JB Kimpel, and O Griffith
Subjects: Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract: Introduction The shape of the glucose curve during an oral glucose tolerance test (OGTT) reflects β-cell function in populations without diabetes but has not been as well studied in those with diabetes. A monophasic shape has been associated with higher risk of diabetes, while a biphasic pattern has been associated with lower risk. We sought to determine if phenotypic or metabolic characteristics were associated with glucose response curve shape in adults with type 2 diabetes treated with metformin alone.Research design and methods This is a cross-sectional analysis of 3108 metformin-treated adults with type 2 diabetes diagnosed
Published: 2021
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6. Pseudomonas aeruginosa Alters Its Transcriptome Related to Carbon Metabolism and Virulence as a Possible Survival Strategy in Blood from Trauma Patients

Author: Moamen M. Elmassry, Nithya S. Mudaliar, Kameswara Rao Kottapalli, Sharmila Dissanaike, John A. Griswold, Michael J. San Francisco, Jane A. Colmer-Hamood, and Abdul N. Hamood
Subjects: Pseudomonas aeruginosa, blood, metabolism, metabolome, sepsis, transcriptome, Microbiology, QR1-502
Abstract: ABSTRACT Trauma patients (TPs) are highly susceptible to infections, which often lead to sepsis. Among the numerous causative agents, Pseudomonas aeruginosa is especially important, as P. aeruginosa sepsis is often fatal. Understanding the mechanism of its pathogenesis in bloodstream infections is imperative; however, this mechanism has not been previously described. To examine the effect of trauma-induced changes in blood on the expression of P. aeruginosa genes, we grew strain UCBPP-PA14 (PA14) in blood samples from eight TPs and seven healthy volunteers (HVs). Compared with its growth in blood from HVs, the growth of PA14 in blood from TPs significantly altered the expression of 285 genes. Genes whose expression was significantly increased were related to carbon metabolism, especially malonate utilization and mannitol uptake, and efflux of heavy metals. Genes whose expression was significantly reduced included genes of the type VI secretion system, genes related to uptake and metabolism of amino acids, and genes related to biosynthesis and transport of the siderophores pyoverdine and pyochelin. These results suggest that during systemic infection in trauma patients, and to adapt to the trauma-induced changes in blood, P. aeruginosa adjusts positively and negatively the expression of numerous genes related to carbon metabolism and virulence, respectively. IMPORTANCE While a considerable body of knowledge regarding sepsis in trauma patients is available, the potential influence of trauma-induced changes in the blood of these patients on the pathogenesis of Pseudomonas aeruginosa is basically an unexplored area. Rather than using standard laboratory media, we grew P. aeruginosa in whole blood from either healthy volunteers or trauma patients. The specific changes in the P. aeruginosa transcriptome in response to growth in blood from trauma patients reflect the adaptation of this organism to the bloodstream environment. This knowledge is vital for understanding the strategies this pathogen uses to adapt and survive within the host during systemic infection. Such information will help researchers and clinicians to develop new approaches for treatment of sepsis caused by P. aeruginosa in trauma patients, especially in terms of recognizing the effects of specific therapies (e.g., iron, zinc, or mannitol) on the organism. Further, this information can most likely be extrapolated to all patients with P. aeruginosa septicemia. Author Video: An author video summary of this article is available.
Published: 2019
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7. Hereditary hemochromatosis promotes colitis and colon cancer and causes bacterial dysbiosis in mice

Author: Abdul N. Hamood, Kameswara Rao Kottapalli, Vadivel Ganapathy, Jane A. Colmer-Hamood, Bojana Ristic, Sathish Sivaprakasam, Anna G. Nevels, Mitchell S. Wachtel, and Nithya S. Mudaliar
Subjects: Colorectal cancer, colitis, Antimicrobial peptides, Inflammation, Biochemistry, hemochromatosis, 03 medical and health sciences, Mice, 0302 clinical medicine, Proteobacteria, medicine, Animals, Microbiome, Colitis, Hemochromatosis Protein, Molecular Biology, Hemochromatosis, Research Articles, 030304 developmental biology, Cancer, Mice, Knockout, 0303 health sciences, business.industry, iron/heme overload, Cell Biology, dysbiosis, medicine.disease, digestive system diseases, Gastrointestinal Microbiome, colon cancer, 030220 oncology & carcinogenesis, Hereditary hemochromatosis, Colonic Neoplasms, Cancer research, medicine.symptom, HFE-null mouse, business, Dysbiosis
Abstract: Hereditary hemochromatosis (HH), an iron-overload disease, is a prevalent genetic disorder. As excess iron causes a multitude of metabolic disturbances, we postulated that iron overload in HH disrupts colonic homeostasis and colon–microbiome interaction and exacerbates the development and progression of colonic inflammation and colon cancer. To test this hypothesis, we examined the progression and severity of colitis and colon cancer in a mouse model of HH (Hfe−/−), and evaluated the potential contributing factors. We found that experimentally induced colitis and colon cancer progressed more robustly in Hfe−/− mice than in wild-type mice. The underlying causes were multifactorial. Hfe−/− colons were leakier with lower proliferation capacity of crypt cells, which impaired wound healing and amplified inflammation-driven tissue injury. The host/microflora axis was also disrupted. Sequencing of fecal 16S RNA revealed profound changes in the colonic microbiome in Hfe−/− mice in favor of the pathogenic bacteria belonging to phyla Proteobacteria and TM7. There was an increased number of bacteria adhered onto the mucosal surface of the colonic epithelium in Hfe−/− mice than in wild-type mice. Furthermore, the expression of innate antimicrobial peptides, the first-line of defense against bacteria, was lower in Hfe−/− mouse colon than in wild-type mouse colon; the release of pro-inflammatory cytokines upon inflammatory stimuli was also greater in Hfe−/− mouse colon than in wild-type mouse colon. These data provide evidence that excess iron accumulation in colonic tissue as happens in HH promotes colitis and colon cancer, accompanied with bacterial dysbiosis and loss of function of the intestinal/colonic barrier.
Published: 2020

8. Effects of powdered rifampin and vancomycin solutions on biofilm production of staphylococcus aureus on orthopedic implants

Author: Abdul N. Hamood, Nithya S. Mudaliar, Christian Douthit, Cyrus Caroom, Mark Jenkins, and Brent M. Gudenkauf
Subjects: Colony-forming unit, 030222 orthopedics, biology, business.industry, medicine.drug_class, Antibiotics, Biofilm, biochemical phenomena, metabolism, and nutrition, biology.organism_classification, medicine.disease_cause, Microbiology, 03 medical and health sciences, 0302 clinical medicine, Staphylococcus aureus, Confocal laser scanning microscopy, Medicine, Vancomycin, Orthopedics and Sports Medicine, 030212 general & internal medicine, business, Rifampicin, Bacteria, medicine.drug
Abstract: Purpose Hardware infections in orthopedic surgery, specifically those involving biofilm producing bacteria, are troublesome and are highly resistant to systemic antibiotics. The purpose of this study was to demonstrate the power of rifampin and vancomycin solutions in inhibiting as well as eliminating in vitro on staphylococcus aureus (S. aureus) biofilm in vitro on stainless-steel implants. Methods A suspension of either S. aureus or a S. aureus containing a plasmid that cods for the green fluorescence protein containing fluorescent protein plasmid was applied to 1 × 1cm sterile stainless steel orthopedic plating material (coupon). Biofilm development was confirmed by; the quantitative assay (colony forming unit [CFU/coupon]) and visualized using confocal laser scanning microscopy. With this established method of biofilm development, we determined the minimum biofilm inhibitory concentration (MBIC) and the minimum biofilm eradication concertation (MBEC) of Rifampicin and Vancomycin. To determine the MBIC, stainless steel plates were subjected to different concentrations of antibiotic solution and inoculated with overnight cultures of S. aureus. After 24 h of incubation at 37 °C, the biofilms on the untreated and antibiotic-treated coupons were quantified. To determine the MBEC, partial S. aureus biofilms were developed on the coupons and then treated with the different concentrations of each antibiotic for 24 h. The number of bacteria within the control untreated as well as treated coupons was determined. Results Both rifampin and vancomycin solutions inhibited biofilm production of S. aureus on stainless steel mediums; the MBIC for rifampin and vancomycin were 80 ng/mL and 1 μg/mL respectively. The MBEC for Rifampicin was similar to the MBIC. However, the MBEC for Vancomycin was 6 mg/ml. Conclusions When applied to orthopedic stainless steel hardware in vitro, solutions of rifampin and vancomycin powder separately or in combination can completely prevent and eliminate biofilm produced by S. aureus. Level of evidence II
Published: 2020
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9. A Space-angle Discontinuous Galerkin Method for Two-Dimensional Radiative Transfer Equation with Reflective Boundary Conditions

Author: H. Wang, R. Abedi, and S. Mudaliar
Published: 2022
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10. Application of Lactobacillus gasseri 63 AM supernatant to Pseudomonas aeruginosa-infected wounds prevents sepsis in murine models of thermal injury and dorsal excision

Author: Joshua Stanbro, Jane A. Colmer-Hamood, Abdul N. Hamood, John C. Zak, Gary Ventolini, Aatiya Ahmad, Nithya S. Mudaliar, Taylor D. Lenzmeier, Chase Watters, and Mark P. Simons
Subjects: 0301 basic medicine, Microbiology (medical), medicine.drug_class, 030106 microbiology, Antibiotics, Ceftazidime, medicine.disease_cause, Lactobacillus gasseri, Microbiology, law.invention, Sepsis, 03 medical and health sciences, Probiotic, In vivo, law, medicine, biology, Pseudomonas aeruginosa, business.industry, Biofilm, General Medicine, biology.organism_classification, medicine.disease, 030104 developmental biology, business, medicine.drug
Abstract: Introduction. Severely burned patients are susceptible to bacterial infection within their burn wounds, which frequently leads to sepsis, multiple organ failure and death. The opportunistic pathogen Pseudomonas aeruginosa , an organism inherently resistant to multiple antibiotics, is a common cause of sepsis in these patients. Aim. Development of a topical treatment unrelated to conventional antibiotics is essential for prevention of P. aeruginosa infection and sepsis, leading to a role for the direct application of probiotics or their by-products. Methodology. We examined the effectiveness of 20× concentrated supernatant from Lactobacillus gasseri strain 63 AM (LgCS) grown in de Man, Rogosa and Sharpe broth in inhibiting P. aeruginosa biofilms in vitro, as well as in reducing wound bioburden and P. aeruginosa sepsis in vivo. Results. LgCS inhibited the growth of P. aeruginosa strain PAO1, prevented its biofilm development and eliminated partially developed PAO1 biofilms. In the murine model of thermal injury, a single injection of LgCS following injury and PAO1 infection reduced mortality to 0 % and prevented systemic spread (sepsis). Furthermore, a second injection of LgCS 24 h after the first eliminated PAO1 from the wound. In the murine dorsal excision infection model, either LgCS or ceftazidime treatment of the PAO1-infected wound significantly reduced the mortality rate among infected mice, while combining LgCS with ceftazidime eliminated mortality. Conclusion. These results suggest the potential of LgCS in preventing sepsis from P. aeruginosa infection in severely burned and other immunocompromised patients.
Published: 2019
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11. Professor Valerian Ill’ich Tatarskii – an appreciation

Author: R. Lataitis, Akira Ishimaru, Mikhail Charnotskii, V.G. Irisov, C. Rino, R. Hill, Lev A. Ostrovsky, Gary S. Brown, Iosif M. Fuks, Yu. A. Kravtsov, James H. Churnside, V. Ostashev, Valentin Freilikher, Alexander G. Voronovich, S. Mudaliar, and Valery U. Zavorotny
Subjects: Valerian, biology, Philosophy, General Engineering, General Physics and Astronomy, Random media, 02 engineering and technology, biology.organism_classification, 01 natural sciences, 010305 fluids & plasmas, 020303 mechanical engineering & transports, 0203 mechanical engineering, 0103 physical sciences, Classics
Abstract: On October 13, 2019 is the ninetieth birthday of the renowned physicist Professor Valerian I. Tatarskii. He is one of the founders of the international journal Waves in Random and Complex Media and...
Published: 2019
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12. New markers for sepsis caused by Pseudomonas aeruginosa during burn infection

Author: Moamen M. Elmassry, Jane A. Colmer-Hamood, Nithya S. Mudaliar, Sharmila Dissanaike, Michael San Francisco, Abdul N. Hamood, and John A. Griswold
Subjects: Chromatography, Gas, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Burn, medicine.disease_cause, 01 natural sciences, Biochemistry, Mass Spectrometry, Microbiology, Sepsis, Mice, 03 medical and health sciences, chemistry.chemical_compound, Metabolomics, medicine, Metabolome, Animals, Gas chromatography with time-of-flight mass spectrometry, 030304 developmental biology, 0303 health sciences, Methionine, Pseudomonas aeruginosa, business.industry, 010401 analytical chemistry, medicine.disease, Uridine, 0104 chemical sciences, Glutamine, Disease Models, Animal, chemistry, Pyrimidine metabolism, Wound Infection, Original Article, Female, Infection, Burns, business, Biomarkers
Abstract: Introduction Sepsis is a leading cause of mortality in burn patients. One of the major causes of sepsis in burn patients is Pseudomonas aeruginosa. We hypothesized that during dissemination from infected burn wounds and subsequent sepsis, P. aeruginosa affects the metabolome of the blood resulting in changes to specific metabolites that would serve as biomarkers for early diagnosis of sepsis caused by P. aeruginosa. Objectives To identify specific biomarkers in the blood after sepsis caused by P. aeruginosa infection of burns. Methods Gas chromatography with time-of-flight mass spectrometry was used to compare the serum metabolome of mice that were thermally injured and infected with P. aeruginosa (B–I) to that of mice that were neither injured nor infected, mice that were injured but not infected, and mice that were infected but not injured. Results Serum levels of 19 metabolites were significantly increased in the B–I group compared to controls while levels of eight metabolites were significantly decreased. Thymidine, thymine, uridine, and uracil (related to pyrimidine metabolism), malate and succinate (a possible sign of imbalance in the tricarboxylic acid cycle), 5-oxoproline (related to glutamine and glutathione metabolism), and trans-4-hydroxyproline (a major component of the protein collagen) were increased. Products of amino acid metabolism were significantly decreased in the B–I group, including methionine, tyrosine, indole-3-acetate, and indole-3-propionate. Conclusion In all, 26 metabolites were identified, including a unique combination of five metabolites (trans-4-hydroxyproline, 5-oxoproline, glycerol-3-galactoside, indole-3-acetate, and indole-3-propionate) that could serve as a set of biomarkers for early diagnosis of sepsis caused by P. aeruginosa in burn patients. Electronic supplementary material The online version of this article (10.1007/s11306-020-01658-2) contains supplementary material, which is available to authorized users.
Published: 2020
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13. Iron-catalyzed cross-dehydrogenative C N coupling of thiohydantoins with various amines

Author: Sulochana S. Mudaliar, Kishor H. Chikhalia, Anuj P. Patel, and Janki J. Patel
Subjects: Reaction conditions, 010405 organic chemistry, Iron catalyzed, Organic Chemistry, Substrate (chemistry), 010402 general chemistry, 01 natural sciences, Biochemistry, 0104 chemical sciences, Coupling (electronics), chemistry.chemical_compound, chemistry, Construction method, Drug Discovery, Polymer chemistry, Organic synthesis, Amination
Abstract: A novel iron-catalyzed C N bond construction method for the hetero-cross-dehydrogenative coupling (CDC) of diverse thiohydantoins with amines utilizing TBHP as the oxidant was developed. This sp3 C H amination at the carbons alpha to carbonyl groups of thiohydantoin tolerates the presence of a wide range of functional groups and provides the corresponding N-substituted amines in moderate to good yields. Various substrate scopes and optimum reaction conditions leads inside in organic synthesis.
Published: 2018
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14. Copper catalysed alkylation of heteroaryl chloride via migratory insertion of carbenes

Author: Shailesh N. Zala, Kishor H. Chikhalia, and Sulochana S. Mudaliar
Subjects: 010405 organic chemistry, Organic Chemistry, Migratory insertion, Cyanuric chloride, chemistry.chemical_element, Alkylation, 010402 general chemistry, 01 natural sciences, Biochemistry, Medicinal chemistry, Copper, Chloride, 0104 chemical sciences, Inorganic Chemistry, chemistry.chemical_compound, chemistry, Reagent, Materials Chemistry, medicine, Organic chemistry, Physical and Theoretical Chemistry, Carbene, Stoichiometry, medicine.drug
Abstract: Cross-coupling reaction involving Cu catalysed carbene migratory insertion with N-tosylhydrazones as the reaction partner with various substituted cyanuric chloride were studied, which has been recognized as a new type of cross-coupling reaction. Cu-carbene migratory insertion is proposed to play the key role in this transformation to form C-C bond from heterohalides with various tosylhydrazones. Salient features of this reactions are (i) no stoichiometric organometallic reagents are required (ii) less toxic and step economical reaction (iii) easy to handle, to get moderate to excellent yields. Outcome of this reaction produces 1,1-heterodiaryl alkanes.
Published: 2017
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15. An Efficient Synthetic Strategy for sp3 (C)-N Amination on 4-thiazolidinone with Primary Heteroaryl Amines

Author: Kishor H. Chikhalia, Sulochana S. Mudaliar, and Mohammedumar M. Shaikh
Subjects: Primary (chemistry), 010405 organic chemistry, Chemistry, 4-thiazolidinone, Organic chemistry, Surface modification, Single step, Amine gas treating, General Chemistry, 010402 general chemistry, 01 natural sciences, Amination, 0104 chemical sciences
Abstract: An efficient sp3(C)-N amination reaction between 4-thiazolidinone and primary heteroaryl amine has been developed under C−H functionalization. Cross-coupling reaction between non-prefunctionalized slightly more acidic sp3 C−H bond of 4-thiazolidinone and different heteroaryl amines involving one-pot synthetic strategy, single step reaction as well as aerial oxidation make this amination more effective than existing methods for the construction of sp3(C)-N bond.
Published: 2017
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16. Application of

Author: Taylor D, Lenzmeier, Nithya S, Mudaliar, Joshua A, Stanbro, Chase, Watters, Aatiya, Ahmad, Mark P, Simons, Gary, Ventolini, John C, Zak, Jane A, Colmer-Hamood, and Abdul N, Hamood
Subjects: Mice, Inbred BALB C, Biological Therapy, Disease Models, Animal, Mice, Lactobacillus gasseri, Biofilms, Sepsis, Antibiosis, Pseudomonas aeruginosa, Superficial Back Muscles, Wound Infection, Animals, Humans, Female, Pseudomonas Infections, Burns
Published: 2019

17. Pseudomonas aeruginosa Alters Its Transcriptome Related to Carbon Metabolism and Virulence as a Possible Survival Strategy in Blood from Trauma Patients

Author: Abdul N. Hamood, Sharmila Dissanaike, Kameswara Rao Kottapalli, Moamen M. Elmassry, Nithya S. Mudaliar, Jane A. Colmer-Hamood, John A. Griswold, and Michael San Francisco
Subjects: Physiology, Virulence, medicine.disease_cause, Biochemistry, Microbiology, sepsis, Transcriptome, Sepsis, Pathogenesis, 03 medical and health sciences, blood, Genetics, Medicine, Novel Systems Biology Techniques, Molecular Biology, Pathogen, Ecology, Evolution, Behavior and Systematics, 030304 developmental biology, Type VI secretion system, Whole blood, 0303 health sciences, business.industry, Pseudomonas aeruginosa, 030302 biochemistry & molecular biology, medicine.disease, QR1-502, Computer Science Applications, virulence, trauma, Modeling and Simulation, metabolome, business, metabolism, transcriptome, Research Article
Abstract: While a considerable body of knowledge regarding sepsis in trauma patients is available, the potential influence of trauma-induced changes in the blood of these patients on the pathogenesis of Pseudomonas aeruginosa is basically an unexplored area. Rather than using standard laboratory media, we grew P. aeruginosa in whole blood from either healthy volunteers or trauma patients. The specific changes in the P. aeruginosa transcriptome in response to growth in blood from trauma patients reflect the adaptation of this organism to the bloodstream environment. This knowledge is vital for understanding the strategies this pathogen uses to adapt and survive within the host during systemic infection. Such information will help researchers and clinicians to develop new approaches for treatment of sepsis caused by P. aeruginosa in trauma patients, especially in terms of recognizing the effects of specific therapies (e.g., iron, zinc, or mannitol) on the organism. Further, this information can most likely be extrapolated to all patients with P. aeruginosa septicemia., Trauma patients (TPs) are highly susceptible to infections, which often lead to sepsis. Among the numerous causative agents, Pseudomonas aeruginosa is especially important, as P. aeruginosa sepsis is often fatal. Understanding the mechanism of its pathogenesis in bloodstream infections is imperative; however, this mechanism has not been previously described. To examine the effect of trauma-induced changes in blood on the expression of P. aeruginosa genes, we grew strain UCBPP-PA14 (PA14) in blood samples from eight TPs and seven healthy volunteers (HVs). Compared with its growth in blood from HVs, the growth of PA14 in blood from TPs significantly altered the expression of 285 genes. Genes whose expression was significantly increased were related to carbon metabolism, especially malonate utilization and mannitol uptake, and efflux of heavy metals. Genes whose expression was significantly reduced included genes of the type VI secretion system, genes related to uptake and metabolism of amino acids, and genes related to biosynthesis and transport of the siderophores pyoverdine and pyochelin. These results suggest that during systemic infection in trauma patients, and to adapt to the trauma-induced changes in blood, P. aeruginosa adjusts positively and negatively the expression of numerous genes related to carbon metabolism and virulence, respectively. IMPORTANCE While a considerable body of knowledge regarding sepsis in trauma patients is available, the potential influence of trauma-induced changes in the blood of these patients on the pathogenesis of Pseudomonas aeruginosa is basically an unexplored area. Rather than using standard laboratory media, we grew P. aeruginosa in whole blood from either healthy volunteers or trauma patients. The specific changes in the P. aeruginosa transcriptome in response to growth in blood from trauma patients reflect the adaptation of this organism to the bloodstream environment. This knowledge is vital for understanding the strategies this pathogen uses to adapt and survive within the host during systemic infection. Such information will help researchers and clinicians to develop new approaches for treatment of sepsis caused by P. aeruginosa in trauma patients, especially in terms of recognizing the effects of specific therapies (e.g., iron, zinc, or mannitol) on the organism. Further, this information can most likely be extrapolated to all patients with P. aeruginosa septicemia.
Published: 2019
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18. Synthesis of 2-, 3- or 4-phenylsubtituted Chalcones Based on 4- phenylamino-6-nitro-2-[(E)-2-phenylvinyl]quinoline, Evaluation of their Antimicrobial and Antifungal Activity

Author: Nisha K. Shah, Kishor H. Chikhalia, and Sulochana S. Mudaliar
Subjects: Antifungal, 010405 organic chemistry, medicine.drug_class, Chemistry, Quinoline, Pharmaceutical Science, Antimicrobial, 01 natural sciences, Combinatorial chemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, Drug Discovery, medicine, Nitro, Molecular Medicine
Published: 2016
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19. An efficient alkynylation of 4-thiazolidinone with terminal alkyne under C–H functionalisation

Author: Kishor H. Chikhalia, Sulochana S. Mudaliar, and Mohammedumar M. Shaikh
Subjects: chemistry.chemical_classification, Reaction conditions, 010405 organic chemistry, Chemistry, Stereochemistry, General Chemical Engineering, One-pot synthesis, Alkyne, chemistry.chemical_element, General Chemistry, 010402 general chemistry, 01 natural sciences, Combinatorial chemistry, Coupling reaction, 0104 chemical sciences, Alkynylation, 4-thiazolidinone, Moiety, Palladium
Abstract: A method of palladium catalysed efficient alkynylation through the cross coupling reaction of terminal alkynes with the slightly more acidic C–H bonds of 4-thiazolidinone has been developed. This method allows the direct introduction of an ethynyl group into the 4-thiazolidinone moiety. Mild reaction conditions involving aerial oxidation and one pot synthesis make this reaction more efficient for the formation of sp3(C)–sp(C) bond.
Published: 2016
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20. Intrawound Vancomycin Powder Reduces Bacterial Load in Contaminated Open Fracture Model

Author: Michael Fry, Abdul N. Hamood, Nithya S. Mudaliar, Jefferson Murphree, Jessica M. Tullar, Ian Ratheal, Cyrus Caroom, Dustin Moore, Craig Winkler, and Mark Jenkins
Subjects: Open fracture, Staphylococcus aureus, medicine.drug_class, medicine.medical_treatment, Antibiotics, Dentistry, Bacterial growth, medicine.disease_cause, Statistics, Nonparametric, Rats, Sprague-Dawley, 03 medical and health sciences, Fractures, Open, Random Allocation, 0302 clinical medicine, Vancomycin, Tobramycin, medicine, Animals, Humans, Surgical Wound Infection, Orthopedics and Sports Medicine, 030222 orthopedics, Debridement, Intraoperative Care, business.industry, 030208 emergency & critical care medicine, General Medicine, Contamination, Rats, Disease Models, Animal, Treatment Outcome, Surgery, Powders, business, Femoral Fractures, medicine.drug
Abstract: OBJECTIVES To compare the effectiveness of both vancomycin powder and antibiotic bead placement to irrigation and debridement alone in prevention of infection in a contaminated open fracture model in rats. METHODS In a previously described model of contaminated open fractures, 45 rats had simulated open fractures created, stabilized, and contaminated with Staphylococcus aureus. They were then treated 6 hours later with 3 interventions: irrigation and debridement alone (control group) or in combination with placement of polymethyl methacrylate beads containing vancomycin and tobramycin powders (antibiotic bead group) or placement of 10 mg of intrawound vancomycin powder (powder group). Rats were allowed to recover and then killed 14 days later for harvest of femurs and plates. Femurs and plates were both incubated overnight, and bacterial colonies were counted in each group for comparison. RESULTS Quantitative counts of bacteria in bone showed significantly reduced growth in both bead and powder groups when compared with control group (P < 0.0001). Quantitative counts of bacteria in plates showed significantly reduced growth in both bead and powder groups when compared with control group (P < 0.0003; 0.029). No significant differences were seen in bacterial growth between bead and powder groups for either bones (P = 0.13) or plates (P = 0.065). CONCLUSIONS When compared with irrigation and debridement alone, placement of intrawound vancomycin powder significantly decreased bacterial load in a contaminated open fracture model in rats similar to placing antibiotic beads. This may provide an additional adjuvant treatment that does not require a secondary surgery for bead removal.
Published: 2018

21. Oxidative Stress and Cardiovascular Risk in Type 1 Diabetes Mellitus: Insights From the DCCT/EDIC Study

Author: W.H. Wilson Tang, Paula McGee, John M. Lachin, Daniel Y. Li, Byron Hoogwerf, Stanley L. Hazen, D.M. Nathan, B. Zinman, O. Crofford, S. Genuth, J. Brown‐Friday, J. Crandall, H. Engel, S. Engel, H. Martinez, M. Phillips, M. Reid, H. Shamoon, J. Sheindlin, R. Gubitosi‐Klug, L. Mayer, S. Pendegast, H. Zegarra, D. Miller, L. Singerman, S. Smith‐Brewer, M. Novak, J. Quin, Saul Genuth, M. Palmert, E. Brown, J. McConnell, P. Pugsley, P. Crawford, W. Dahms, N.S. Gregory, M.E. Lackaye, S. Kiss, R. Chan, A. Orlin, M. Rubin, D. Brillon, V. Reppucci, T. Lee, M. Heinemann, S. Chang, B. Levy, L. Jovanovic, M. Richardson, B. Bosco, A. Dwoskin, R. Hanna, S. Barron, R. Campbell, A. Bhan, D. Kruger, J.K. Jones, P.A. Edwards, J.D. Carey, E. Angus, A. Thomas, A. Galprin, M. McLellan, F. Whitehouse, R. Bergenstal, M. Johnson, K. Gunyou, L. Thomas, J. Laechelt, P. Hollander, M. Spencer, D. Kendall, R. Cuddihy, P. Callahan, S. List, J. Gott, N. Rude, B. Olson, M. Franz, G. Castle, R. Birk, J. Nelson, D. Freking, L. Gill, W. Mestrezat, D. Etzwiler, K. Morgan, L.P. Aiello, E. Golden, P. Arrigg, V. Asuquo, R. Beaser, L. Bestourous, J. Cavallerano, R. Cavicchi, O. Ganda, O. Hamdy, R. Kirby, T. Murtha, D Schlossman, S. Shah, G. Sharuk, P. Silva, P. Silver, M. Stockman, J. Sun, E. Weimann, H. Wolpert, L.M. Aiello, A. Jacobson, L. Rand, J. Rosenzwieg, M.E. Larkin, M. Christofi, K. Folino, J. Godine, P. Lou, C. Stevens, E. Anderson, H. Bode, S. Brink, C. Cornish, D. Cros, L. Delahanty, eManbey, C. Haggan, J. Lynch, C. McKitrick, D. Norman, D. Moore, M. Ong, C. Taylor, D. Zimbler, S. Crowell, S. Fritz, K. Hansen, C. Gauthier‐Kelly, F.J. Service, G. Ziegler, A. Barkmeier, L. Schmidt, B. French, R. Woodwick, R. Rizza, W.F. Schwenk, M. Haymond, J. Pach, J. Mortenson, B. Zimmerman, A. Lucas, R. Colligan, L. Luttrell, M. Lopes‐Virella, S. Caulder, C. Pittman, N. Patel, K. Lee, M. Nutaitis, J. Fernandes, K. Hermayer, S. Kwon, A Blevins, J. Parker, J. Colwell, D. Lee, J. Soule, P. Lindsey, M. Bracey, A. Farr, S. Elsing, T. Thompson, J. Selby, T. Lyons, S. Yacoub‐Wasef, M. Szpiech, D. Wood, R. Mayfield, M. Molitch, D. Adelman, S. Colson, L. Jampol, A. Lyon, M. Gill, Z. Strugula, L. Kaminski, R. Mirza, E. Simjanoski, D. Ryan, C. Johnson, A. Wallia, S. Ajroud‐Driss, P. Astelford, N. Leloudes, A. Degillio, B. Schaefer, S. Mudaliar, G Lorenzi, M. Goldbaum, K. Jones, M. Prince, M. Swenson, I. Grant, R. Reed, R. Lyon, O. Kolterman, M. Giotta, T. Clark, G. Friedenberg, W.I. Sivitz, B. Vittetoe, J. Kramer, M. Bayless, R. Zeitler, H. Schrott, N. Olson, L. Snetselaar, R. Hoffman, J. MacIndoe, T. Weingeist, C. Fountain, R. Miller, S. Johnsonbaugh, M. Patronas, M. Carney, S. Mendley, P. Salemi, R. Liss, M. Hebdon, D. Counts, T. Donner, J. Gordon, R. Hemady, A. Kowarski, D. Ostrowski, S. Steidl, B. Jones, W.H. Herman, C.L. Martin, R. Pop‐Busui, D.A. Greene, M.J. Stevens, N. Burkhart, T. Sandford, J. Floyd, J. Bantle, N. Flaherty, J. Terry, D. Koozekanani, S. Montezuma, N. Wimmergren, B. Rogness, M. Mech, T. Strand, J. Olson, L. McKenzie, C. Kwong, F. Goetz, R. Warhol, D. Hainsworth, D. Goldstein, S. Hitt, J. Giangiacomo, D.S Schade, J.L. Canady, M.R. Burge, A. Das, R.B. Avery, L.H. Ketai, J.E. Chapin, M.L. Schluter, J. Rich, C. Johannes, D. Hornbeck, M. Schutta, P.A. Bourne, A. Brucker, S. Braunstein, S. Schwartz, B.J. Maschak‐Carey, L. Baker, T. Orchard, L. Cimino, T. Songer, B. Doft, S. Olson, D. Becker, D. Rubinstein, R.L. Bergren, J. Fruit, R. Hyre, C. Palmer, N. Silvers, L. Lobes, P. Paczan Rath, P.W. Conrad, S. Yalamanchi, J. Wesche, M. Bratkowksi, S. Arslanian, J. Rinkoff, J. Warnicki, D. Curtin, D. Steinberg, G. Vagstad, R. Harris, L. Steranchak, J. Arch, K. Kelly, P. Ostrosaka, M. Guiliani, M. Good, T. Williams, K. Olsen, A. Campbell, C. Shipe, R. Conwit, D. Finegold, M. Zaucha, A. Drash, A. Morrison, J.I. Malone, M.L. Bernal, P.R. Pavan, N. Grove, E.A. Tanaka, D. McMillan, J. Vaccaro‐Kish, L. Babbione, H. Solc, T.J. DeClue, S. Dagogo‐Jack, C. Wigley, H. Ricks, A. Kitabchi, E. Chaum, M.B. Murphy, S. Moser, D. Meyer, A. Iannacone, S. Yoser, M. Bryer‐Ash, S. Schussler, H. Lambeth, P. Raskin, S. Strowig, M. Basco, S. Cercone, A. Barnie, R. Devenyi, M. Mandelcorn, M. Brent, S. Rogers, A. Gordon, N. Bakshi, B. Perkins, L. Tuason, F. Perdikaris, R. Ehrlich, D. Daneman, K. Perlman, S Ferguson, J. Palmer, R. Fahlstrom, I.H. de Boer, J. Kinyoun, L. Van Ottingham, S. Catton, J. Ginsberg, C. McDonald, J. Harth, M. Driscoll, T. Sheidow, J. Mahon, C. Canny, D. Nicolle, P. Colby, J. Dupre, I. Hramiak, N.W. Rodger, M. Jenner, T. Smith, W. Brown, M. May, J. Lipps Hagan, A. Agarwal, T. Adkins, R. Lorenz, S. Feman, L. Survant, N.H. White, L. Levandoski, G. Grand, M. Thomas, D. Joseph, K. Blinder, G. Shah, D. Burgess, I. Boniuk, J. Santiago, W. Tamborlane, P. Gatcomb, K. Stoessel, P. Ramos, K. Fong, P. Ossorio, J. Ahern, L. Meadema‐Mayer, C. Beck, K. Farrell, J Quin, P. Gaston, R. Trail, J. Lachin, J. Backlund, I. Bebu, B. Braffett, L. Diminick, X. Gao, W. Hsu, K. Klumpp, H. Pan, V. Trapani, P. Cleary, P. McGee, W. Sun, S. Villavicencio, K. Anderson, L. Dews, Naji Younes, B. Rutledge, K. Chan, D. Rosenberg, B. Petty, A. Determan, D. Kenny, C. Williams, C. Cowie, C. Siebert, M. Steffes, V. Arends, J. Bucksa, M. Nowicki, B. Chavers, D. O'Leary, J. Polak, A. Harrington, L. Funk, R Crow, B. Gloeb, S. Thomas, C. O'Donnell, E.Z. Soliman, Z.M. Zhang, Y. Li, C. Campbell, L. Keasler, S. Hensley, J. Hu, M. Barr, T. Taylor, R. Prineas, E.L. Feldman, J.W. Albers, P. Low, C. Sommer, K. Nickander, T. Speigelberg, M. Pfiefer, M. Schumer, M. Moran, J. Farquhar, C. Ryan, D. Sandstrom, M. Geckle, E. Cupelli, F. Thoma, B. Burzuk, T. Woodfill, R. Danis, B. Blodi, D. Lawrence, H. Wabers, S. Gangaputra, S. Neill, M. Burger, J. Dingledine, V. Gama, R. Sussman, M. Davis, L. Hubbard, M. Budoff, S. Darabian, P. Rezaeian, N. Wong, M. Fox, R. Oudiz, L Kim, R. Detrano, K. Cruickshanks, D. Dalton, K. Bainbridge, J. Lima, D. Bluemke, E. Turkbey, der Geest, C. Liu, A. Malayeri, A. Jain, C. Miao, H. Chahal, R. Jarboe, V. Monnier, D. Sell, C. Strauch, S. Hazen, A. Pratt, W. Tang, J. Brunzell, J. Purnell, R. Natarajan, F. Miao, L. Zhang, Z. Chen, A. Paterson, A. Boright, S. Bull, L. Sun, S. Scherer, T.J. Lyons, A. Jenkins, R. Klein, G. Virella, A. Jaffa, R. Carter, J. Stoner, W.T. Garvey, D. Lackland, M. Brabham, D. McGee, D. Zheng, R.K. Mayfield, J. Maynard, H. Wessells, A Sarma, R. Dunn, S. Holt, J. Hotaling, C. Kim, Q. Clemens, J. Brown, and K. McVary
Subjects: medicine.medical_specialty, endocrine system diseases, 030209 endocrinology & metabolism, Disease, 030204 cardiovascular system & hematology, Lower risk, medicine.disease_cause, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Diabetes mellitus, medicine, Diseases of the circulatory (Cardiovascular) system, Coronary Heart Disease, Glycemic, Original Research, free radical, Inflammation, Type 1 diabetes, biology, business.industry, Paraoxonase, medicine.disease, paraoxonase, 3. Good health, RC666-701, Cohort, diabetes mellitus, biology.protein, Cardiology and Cardiovascular Medicine, business, Oxidant Stress, Oxidative stress, F2Isoprostane, Biomarkers
Abstract: Background Hyperglycemia leading to increased oxidative stress is implicated in the increased risk for the development of macrovascular and microvascular complications in patients with type 1 diabetes mellitus. Methods and Results A random subcohort of 349 participants was selected from the DCCT / EDIC (Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications) cohort. This included 320 controls and 29 cardiovascular disease cases that were augmented with 98 additional known cases to yield a case cohort of 447 participants (320 controls, 127 cases). Biosamples from DCCT baseline, year 1, and closeout of DCCT , and 1 to 2 years post‐ DCCT ( EDIC years 1 and 2) were measured for markers of oxidative stress, including plasma myeloperoxidase, paraoxonase activity, urinary F 2α isoprostanes, and its metabolite, 2,3 dinor‐8 iso prostaglandin F 2α . Following adjustment for glycated hemoblobin and weighting the observations inversely proportional to the sampling selection probabilities, higher paraoxonase activity, reflective of antioxidant activity, and 2,3 dinor‐8 iso prostaglandin F 2α , an oxidative marker, were significantly associated with lower risk of cardiovascular disease (−4.5% risk for 10% higher paraoxonase, P iso prostaglandin F 2α , P =0.0092). In contrast, the oxidative markers myeloperoxidase and F 2α isoprostanes were not significantly associated with cardiovascular disease after adjustment for glycated hemoblobin. There were no significant differences between DCCT intensive and conventional treatment groups in the change in all biomarkers across time segments. Conclusions Heightened antioxidant activity (rather than diminished oxidative stress markers) is associated with lower cardiovascular disease risk in type 1 diabetes mellitus, but these biomarkers did not change over time with intensification of glycemic control. Clinical Trial Registration URL : https://www.clinicaltrials.gov . Unique identifiers: NCT 00360815 and NCT 00360893.
Published: 2018

22. Improving Access to Minimal Residual Disease Assessment: Lessons Learnt!

Author: Poonam Bagai, Shruti Jain, S. Mudaliar, Amitabh Singh, Nita Radhakrishnan, K. Sehgal, Haresh Gupta, P. Jain, Shruti Kakkar, K.L. Garg, Minu Singh, N. Dang, S.K. Digra, Jagdish Chandra, A. Rajendran, Amita Mahajan, and Nishant Verma
Subjects: medicine.medical_specialty, Oncology, business.industry, Pediatrics, Perinatology and Child Health, Medicine, Hematology, business, Intensive care medicine, Minimal residual disease
Published: 2019
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23. Choice of early treatment regimen and impact on β-cell preservation in type 2 diabetes

Author: S Mudaliar
Subjects: medicine.medical_specialty, medicine.medical_treatment, Decision Making, Type 2 diabetes, Diabetes Complications, Insulin resistance, Insulin-Secreting Cells, Internal medicine, Diabetes mellitus, Insulin Secretion, medicine, Humans, Hypoglycemic Agents, Insulin, Prediabetes, Intensive care medicine, Prospective cohort study, business.industry, Type 2 Diabetes Mellitus, General Medicine, medicine.disease, Clinical trial, Early Diagnosis, Endocrinology, Diabetes Mellitus, Type 2, Disease Progression, business, Risk Reduction Behavior
Abstract: The progressive deterioration of glycaemic control in individuals with type 2 diabetes mellitus (T2DM) results from insulin resistance combined with the ongoing loss of β-cell function. Although it had been suggested that most β-cell dysfunction occurs after the development of T2DM, studies have documented a substantial early loss of β-cell function, particularly during the prediabetic state. In patients diagnosed with T2DM, β-cell function continues to decline despite treatment with commonly prescribed antihyperglycaemic medications, and ultimately exogenous insulin administration is required to maintain optimal glycaemic control. Thus, interventions to address the early decline in β-cell function could potentially alter the course of T2DM, preventing or delaying its onset and decreasing the incidence of complications. Original research and review articles on this topic were identified in a PubMed search from January 2000 through August 2012. Data from prospective studies and clinical trials suggest that lifestyle modifications and certain antihyperglycaemic medications, including thiazolidinediones (TZDs), glucagon-like peptide-1 (GLP-1) agonists, dipeptidyl peptidase-4 (DPP-4) inhibitors and insulin, may preserve or enhance β-cell function. The implication of current data is that early initiation of lifestyle modifications and antihyperglycaemic agents that preserve β-cell function might reverse or delay progression to T2DM in those with prediabetes. Moreover, improved β-cell function may confer more durable glucose control and perhaps reduce/delay the incidence of diabetic complications. Long-term studies are needed to validate this hypothesis.
Published: 2013
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24. ChemInform Abstract: An Efficient Alkynylation of 4-Thiazolidinone with Terminal Alkyne under C-H Functionalization

Author: Sulochana S. Mudaliar, Kishor H. Chikhalia, and Mohammedumar M. Shaikh
Subjects: chemistry.chemical_classification, Alkynylation, Terminal (electronics), Chemistry, 4-thiazolidinone, Surface modification, Alkyne, General Medicine, Combinatorial chemistry
Published: 2016
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25. Development of a Serum Therapy to Protect Severely Burned Patients from Pseudomonas Aeruginosa

Author: Sharmila Dissanaike, Abdul N. Hamood, Emily Bouffard, Jane A. Colmer-Hamood, Nithya S. Mudaliar, and John A. Griswold
Subjects: business.industry, Pseudomonas aeruginosa, Medicine, Surgery, business, medicine.disease_cause, Microbiology
Published: 2018
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26. On the Application of the Radiative Transfer Approach to Scattering from a Random Medium Layer with Rough Boundaries

Author: S. Mudaliar
Subjects: Surface (mathematics), Scattering, Operator (physics), Mathematical analysis, General Physics and Astronomy, Boundary (topology), Geometry, Electronic, Optical and Magnetic Materials, Radiative transfer, Boundary value problem, Electrical and Electronic Engineering, Layer (object-oriented design), Intensity (heat transfer), Mathematics
Abstract: For studying the problem of scattering from a random medium layer with rough boundaries the radiative transfer (RT) approach is widely used. In order to better understand this procedure we compared it with the statistical wave approach. Two such wave approaches are presented in this paper: the surface scattering operator (SSO) approach, and the unified approach. In both wave approaches two conditions are essential for arriving at RT system: the ladder approximation to the intensity operator, and the quasi-stationary approximation of fields. With these approximations one arrives at the integro-differential equations of the RT system. However, to arrive at the RT boundary conditions, one has to impose further approximations. In the SSO approach weak surface correlation must be imposed. In the unified approach, one has to ignore the terms involving volumetric spectral densities, and consider only single scattering from the rough boundary when deriving the boundary conditions.
Published: 2006
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27. Some Properties of Green's Functions of Waves At Boundaries

Author: S. Mudaliar
Subjects: Wave propagation, Mathematical analysis, Isotropy, General Physics and Astronomy, Boundary (topology), Dirac delta function, Geometry, Acoustic wave, Disjoint sets, Electronic, Optical and Magnetic Materials, symbols.namesake, Perfectly matched layer, symbols, Boundary value problem, Electrical and Electronic Engineering, Mathematics
Abstract: Some properties of Green's functions of waves at boundaries are presented in this paper. Of particular interest is their behaviour like Dirac delta distributions whose domain is the manifold of the boundary under consideration. We have obtained relations involving dyadic Green's functions for electromagnetic wave scattering problems with PEC, PMC and penetrable boundaries. Both isotropic and anisotropic homogeneous media are considered. Situations with multiple bodies with disjoint smooth boundaries are also part of our study. Some similar results for acoustic waves are given without proofs.
Published: 2002
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28. Incoherent intensities of electromagnetic waves in a random medium layer and radiative transfer theory

Author: S. Mudaliar
Subjects: Physics, Bethe–Salpeter equation, Wave propagation, Incoherent scatter, Random media, Electromagnetic radiation, Atomic and Molecular Physics, and Optics, Computational physics, Matrix (mathematics), Quantum electrodynamics, Radiative transfer, Radiative transfer theory, Boundary value problem, Mueller calculus, Layer (electronics)
Abstract: Equations for incoherent intensities are obtained for electromagnetic waves in a random medium layer with plane parallel boundaries. These are based on the Bethe–Salpeter equation under the ladder approximation. These equations are then compared with the radiative transfer equations for this problem. Differences between these two approaches are pointed out and discussed. The Muller matrix is derived based on a first-order approximation to the equations for incoherent intensities which is then used to highlight the significance of the above-mentioned differences in radar cross-section computations.
Published: 2001
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29. Diffuse waves in a random medium layer with rough boundaries

Author: S Mudaliar
Subjects: Heterogeneous random walk in one dimension, Scattering, Integro-differential equation, Operator (physics), Mathematical analysis, General Physics and Astronomy, Random media, Summation equation, Layer (object-oriented design), Integral equation, Mathematics
Abstract: The problem of scattering from a random medium layer with rough boundaries is formulated as an integral equation in which the random fluctuations are represented as a zero-mean random operator. The analysis for the diffuse fields is based on the ladder-approximated Bethe–Salpeter equation. An integral equation for the diffuse intensities thus derived displays the various multiple-scattering processes involved in our problem. Transport equations are also derived and several special cases are considered to illustrate the characteristics of the results and to compare them with those in the literature.
Published: 2001
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30. Coherent Scattering of Electromagnetic Waves From a Layer of Random Medium With Rough Boundaries

Author: S. Mudaliar
Subjects: Surface (mathematics), Operator (computer programming), Scattering, Mathematical analysis, General Physics and Astronomy, Boundary value problem, Electrical and Electronic Engineering, Fresnel equations, Electromagnetic radiation, Integral equation, Smoothing, Electronic, Optical and Magnetic Materials, Mathematics
Abstract: This paper is concerned about coherent waves in a random medium layer with randomly rough boundaries which on the average are parallel planes. The fluctuations of the problem are assumed to be small and smooth. All the statistical parameters of the problem are stationary and independent of each other. The bottom surface is assumed to be perfectly conducting. Using transferred boundary conditions the problem of electromagnetic wave scattering from this layer is formulated as a single integral equation where the random fluctuations of the problem are represented as a zero mean random operator. Smoothing leads to an integral equation for the coherent fields. Various operators are employed to this equation to obtain expressions for the principal parameters of the coherent fields such as propagation constants and Fresnel coefficients. Some examples are considered to illustrate the characteristics of our results.
Published: 2001
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31. Radar cross sections of a random medium layer

Author: S. Mudaliar
Subjects: Permittivity, business.industry, Gaussian, Mathematical analysis, General Physics and Astronomy, Random media, law.invention, symbols.namesake, Optics, law, symbols, Radar, Layer (object-oriented design), business, Mathematics
Abstract: Analytic expressions are derived for the normalized radar cross sections (NRCS) of a random medium layer. These are calculated from the first-order solutions for diffuse intensities which are based on a multiple-scattering wave theoretical analysis. The permittivity fluctuations are assumed to be small and to obey stationary Gaussian statistics. On studying the expressions for the NRCS, some of their characteristics are pointed out. Three different correlation functions are considered and expressions for the coherent propagation constants are provided. Numerical examples are used to verify theoretical results and highlight some interesting characteristics of NRCS.
Published: 2000
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32. Transformations for a Class of Hypergeometric Functions

Author: S. Mudaliar
Subjects: Basic hypergeometric series, Pure mathematics, Confluent hypergeometric function, Hypergeometric function of a matrix argument, Bilateral hypergeometric series, Appell series, Mathematical analysis, Mathematics::Classical Analysis and ODEs, General Physics and Astronomy, Generalized hypergeometric function, Electronic, Optical and Magnetic Materials, Barnes integral, Hypergeometric identity, Electrical and Electronic Engineering, Mathematics
Abstract: This paper is concerned about power series expansions for hypergeometric functions in two variables. The usual power series representations for such functions have limited range of validity. Of particular interest is the case when the magnitude of one of the variables becomes large. Using a Barnes-type integral representation the region of convergence is transferred to the desired domain. The poles that occur in the Barnes-type integral are assumed to be simple. Thus explicit expansions are obtained for each of the fourteen hypergeometric functions that belong to this class.
Published: 2000
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33. Scattering from a rough layer of a random medium

Author: S Mudaliar
Subjects: symbols.namesake, Partial differential equation, Scattering, Helmholtz free energy, Mathematical analysis, symbols, General Physics and Astronomy, Boundary (topology), Boundary value problem, Integral equation, Poincaré–Steklov operator, Fourier integral operator, Mathematics
Abstract: This paper deals with scattering from a random-medium layer with rough boundaries. The fluctuations of the surface heights and medium permittivity are assumed to be small and smooth. All random quantities are assumed to be stationary and independent of each other. After the introduction of approximate boundary conditions, the system of partial differential equations is transformed into an integral equation where the fluctuations of the problem are represented as a zero-mean random operator. Employing smoothing, integral equations for the coherent fields are obtained. Use of the Helmholtz operator leads to solution for the coherent propagation constant while the boundary operators lead to coherent Fresnel coefficients. The characteristics of the results are illustrated by considering several examples.
Published: 1999
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34. PPAR-gamma gene expression is elevated in skeletal muscle of obese and type II diabetic subjects

Author: K. S. Park, T. P. Ciaraldi, L. Abrams-Carter, S. Mudaliar, S. E. Nikoulina, and R. R. Henry
Subjects: Endocrinology, Diabetes and Metabolism, Internal Medicine
Published: 1997
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35. Regulation of glycogen synthase activity in cultured skeletal muscle cells from subjects with type II diabetes: role of chronic hyperinsulinemia and hyperglycemia

Author: S. E. Nikoulina, T. P. Ciaraldi, L. Abrams-Carter, S. Mudaliar, K. S. Park, and R. R. Henry
Subjects: Endocrinology, Diabetes and Metabolism, Internal Medicine
Published: 1997
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36. Acoustic wave scattering from a randomly rough surface

Author: S. Mudaliar
Subjects: Surface (mathematics), Physics, Acoustic wave scattering, Optics, Scattering, business.industry, Rough surface, General Physics and Astronomy, Acoustic wave equation, Boundary value problem, business, Computational physics
Abstract: Acoustic wave scattering from a randomly rough surface is studied using a multiple scattering analysis. Assuming the surface asperities to be small, approximate boundary conditions are used to derive a pair of coupled integral equations for the velocity potentials. The Dyson equation is next derived on introducing symbolic operators. Using the bilocal approximation the Dyson equation is solved, thereby obtaining explicit expressions for the coherent reflection and transmission coefficients. The analysis is similarly carried on further to compute the incoherent intensity by using the ladder approximation, and hence an expression for the scattering coefficient is obtained.
Published: 1996
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37. Acquired defects of glycogen synthase activity in cultured human skeletal muscle cells: influence of high glucose and insulin levels

Author: R. R. Henry, T. P. Ciaraldi, S. Mudaliar, L. Abrams, and S. E. Nikoulina
Subjects: Endocrinology, Diabetes and Metabolism, Internal Medicine
Published: 1996
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38. Communication through a plasma sheath around a fast moving vehicle

Author: V. Sotnikov, Bryan V. Oliver, S. Mudaliar, Thomas Alan Mehlhorn, and T. C. Genoni
Subjects: Physics, Scattering, Turbulence, Wave turbulence, Scattering length, Mechanics, Plasma oscillation, Electromagnetic radiation, Physics::Fluid Dynamics, Classical mechanics, Flow velocity, Physics::Plasma Physics, Physics::Space Physics, Electromagnetic electron wave
Abstract: Investigation of the complicated problem of scattering of electromagnetic waves on turbulent pulsations induced by a sheared flow inside a plasma sheath is important for many applications including communication with hypersonic and reentry vehicles. Theoretical and computational work aimed at improving the understanding of electromagnetic wave scattering processes in such turbulent plasmas is presented. We analyze excitation of low frequency ion-acoustic type oscillations in a compressible plasma flow with flow velocity shear and influence of such turbulent pulsations on scattering of high frequency electromagnetic waves used for communication purposes. The nonlinear system of equations which describes excitation and nonlinear dynamics of low frequency wave turbulence inside a plasma sheath was solved numerically. Results of numerical solutions for plasma density and electric field perturbations for different velocity profiles have been used in the derived expressions for scattered wave energy and scattering cross section. We have appropriately included in our analysis the presence of electron and ion collisions with neutrals as well as electron - ion collisions. An exact expression for the scattering cross section is derived within the framework of single-scattering perturbation theory and the case of incident wave with p-polarization is considered in detail. This approach allows investigation of the scattering process for profiles with different flow velocity shear when representation of excited density and wave field turbulence in analytical form is difficult to obtain.
Published: 2011
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39. Scattering of electromagnetic waves in the presence of wave turbulence inside a plasma sheath around a hypersonic vehicle

Author: V.I. Sotnikov, J.N. Leboeuf, and S. Mudaliar
Subjects: Physics::Fluid Dynamics, Physics, Classical mechanics, Flow velocity, Scattering, Turbulence, Wave propagation, Wave turbulence, Physics::Space Physics, Electromagnetic electron wave, Mechanics, Scattering theory, Electromagnetic radiation
Abstract: Summary form only given. Investigation of the complicated problem of scattering of electromagnetic waves on turbulent pulsations induced by a sheared flow inside a plasma sheath is important for many applications including communication with hypersonic and re-entry vehicles. Theoretical and computational work aimed at improving the understanding of electromagnetic wave scattering processes in such turbulent plasmas is presented. We analyze excitation of low frequency ion-acoustic type oscillations and vortices in a compressible plasma flow with flow velocity shear and influence of such turbulent pulsations on scattering of high frequency electromagnetic waves used for communication purposes. The nonlinear system of equations which describes excitation and nonlinear dynamics of low frequency wave turbulence inside a plasma sheath was solved numerically. For these purposes the numerical code IAW2D was developed. Results of numerical solutions for plasma density and electric field perturbations for different velocity profiles have been used in the derived expressions for scattered wave energy and scattering cross section. An exact expression for the scattering cross section is derived within the framework of single-scattering perturbation theory and the case of incident wave with p-polarization is considered in detail. This approach allows investigation of the scattering process for profiles with different flow velocity shear when representation of excited density and wave field turbulence in analytical form is difficult to obtain.
Published: 2009
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40. Detection of antibodies to Brucella abortus in animal handlers

Author: S, Mudaliar, A, Bhore, and D, Pandit
Subjects: Occupational Diseases, Veterinary Medicine, Dairying, Brucella abortus, Humans, India, Animal Husbandry, Antibodies, Bacterial, Brucellosis
Abstract: 1. Our study showed a prevalence of 5.33% in animal handlers working in an urban city like Pune. The prevalence would definitely be higher in a population from a rural area. 2. All these cases who showed presence of antibodies to B. abortus, had varied clinical manifestations, characteristic of the protean manifestations in brucellosis. Likewise in our study we had cases ranging from arthritis, abortions and genito urinary manifestations. 3. All the antibody positive cases had significant antibody titres. The clinicians miss many cases of brucellosis because it is not considered as an alternative diagnosis. The clinician should keep in mind the possibility of an occupational or environmental exposure in cases of P.U.O. It would also be worthwhile to create awareness of the disease in such professions so that necessary precautions and periodic screening of such occupationally exposed people can be done. Studies are needed to assess the role of brucellosis as a cause of morbidity in India, which had not received the attention it deserved. Prevention of human brucellosis focuses mainly on elimination of infection in cattle along with hygiene, vaccine, and effective heating and pasteurization of dairy products and related foods.
Published: 2003

41. Glucosamine regulation of glucose metabolism in cultured human skeletal muscle cells: divergent effects on glucose transport/phosphorylation and glycogen synthase in non-diabetic and type 2 diabetic subjects

Author: T P, Ciaraldi, L, Carter, S, Nikoulina, S, Mudaliar, D A, McClain, and R R, Henry
Subjects: Adult, Glucosamine, Glucose, Glycogen Synthase, Diabetes Mellitus, Type 2, Monosaccharide Transport Proteins, Reference Values, Humans, Biological Transport, Phosphorylation, Muscle, Skeletal, Cells, Cultured
Abstract: Chronic exposure (48 h) to glucosamine resulted in a dose-dependent reduction of basal and insulin-stimulated glucose uptake activities in human skeletal muscle cell cultures from nondiabetic and type 2 diabetic subjects. Insulin responsiveness of uptake was also reduced. There was no change in total membrane expression of either GLUT1, GLUT3, or GLUT4 proteins. While glucosamine treatment had no significant effects on hexokinase activity measured in cell extracts, glucose phosphorylation in intact cells was impaired after treatment. Under conditions where glucose transport and phosphorylation were down regulated, the fractional velocity (FV) of glycogen synthase was increased by glucosamine treatment. Neither the total activity nor protein expression of glycogen synthase were influenced by glucosamine treatment. The stimulation of glycogen synthase by glucosamine was not due totally to soluble mediators. Reflective of the effects on transport/phosphorylation, total glycogen content and net glycogen synthesis were reduced after glucosamine treatment. These effects were similar in nondiabetic and type 2 cells. In summary: 1) Chronic treatment with glucosamine reduces glucose transport/phosphorylation and storage into glycogen in skeletal muscle cells in culture and impairs insulin responsiveness as well. 2) Down-regulation of glucose transport/phosphorylation occurs at a posttranslational level of GLUTs. 3) Glycogen synthase activity increases with glucosamine treatment. 4) Nondiabetic and type 2 muscle cells display equal sensitivity and responsiveness to glucosamine. Increased exposure of skeletal muscle to glucosamine, a substrate/precursor of the hexosamine pathway, alters intracellular glucose metabolism at multiple sites and can contribute to insulin resistance in this tissue.
Published: 1999

42. Effects of tumor necrosis factor-alpha on glucose metabolism in cultured human muscle cells from nondiabetic and type 2 diabetic subjects

Author: T P, Ciaraldi, L, Carter, S, Mudaliar, P A, Kern, and R R, Henry
Subjects: Adult, Glucose, Glycogen Synthase, Diabetes Mellitus, Type 2, Monosaccharide Transport Proteins, Reference Values, Tumor Necrosis Factor-alpha, Humans, Middle Aged, Muscle, Skeletal, Cells, Cultured, Glycogen
Abstract: The effects of tumor necrosis factor-alpha (TNF alpha) on glucose uptake and glycogen synthase (GS) activity were studied in human skeletal muscle cell cultures from nondiabetic and type 2 diabetic subjects. In nondiabetic muscle cells, acute (90-min) exposure to TNF alpha (5 ng/ml) stimulated glucose uptake (73 +/- 14% increase) to a greater extent than insulin (37 +/- 4%; P0.02). The acute uptake response to TNF alpha in diabetic cells (51 +/- 6% increase) was also greater than that to insulin (31 +/- 3%; P0.05). Prolonged (24-h) exposure of nondiabetic muscle cells to TNF alpha resulted in a further stimulation of uptake (152 +/- 31%; P0.05), whereas the increase in cells from type 2 diabetics was not significant compared with that in cells receiving acute treatment. After TNF alpha treatment, the level of glucose transporter-1 protein was elevated in nondiabetic (4.6-fold increase) and type 2 (1.7-fold) cells. Acute TNF alpha treatment had no effect on the fractional velocity of GS in either nondiabetic or type 2 cells. Prolonged exposure reduced the GS fractional velocity in both nondiabetic and diabetic cells. In summary, both acute and prolonged treatment with TNF alpha up-regulate glucose uptake activity in cultured human muscle cells, but reduce GS activity. Increased skeletal muscle glucose uptake in conditions of TNF alpha excess may serve as a compensatory mechanism in the insulin resistance of type 2 diabetes.
Published: 1998

43. Troglitazone effects on gene expression in human skeletal muscle of type II diabetes involve up-regulation of peroxisome proliferator-activated receptor-gamma

Author: K S, Park, T P, Ciaraldi, K, Lindgren, L, Abrams-Carter, S, Mudaliar, S E, Nikoulina, S R, Tufari, J H, Veerkamp, A, Vidal-Puig, and R R, Henry
Subjects: Adult, Tumor Suppressor Proteins, Gene Expression, Receptors, Cytoplasmic and Nuclear, Middle Aged, Fatty Acid-Binding Proteins, Myelin P2 Protein, Neoplasm Proteins, Up-Regulation, Thiazoles, Troglitazone, Diabetes Mellitus, Type 2, Gene Expression Regulation, Humans, Hypoglycemic Agents, Thiazolidinediones, RNA, Messenger, Chromans, Carrier Proteins, Fatty Acid-Binding Protein 7, Muscle, Skeletal, Cells, Cultured, Transcription Factors
Abstract: Troglitazone, besides improving insulin action in insulin-resistant subjects, is also a specific ligand for the nuclear receptor peroxisome proliferator-activated receptor-gamma (PPARgamma). To determine whether troglitazone might enhance insulin action by stimulation of PPARgamma gene expression in muscle, total PPARgamma messenger RNA (mRNA), and protein were determined in skeletal muscle cultures from nondiabetic control and type II diabetic subjects before and after treatment of cultures with troglitazone (4 days +/- troglitazone, 11.5 microM). Troglitazone treatment increased PPARgamma mRNA levels up to 3-fold in muscle cultures from type II diabetics (277 +/- 63 to 630 +/- 100 x 10(3) copies/microg total RNA, P = 0.003) and in nondiabetic control subjects (200 +/- 42 to 490 +/- 81, P = 0.003). PPARgamma protein levels in both diabetic (4.7 +/- 1.6 to 13.6 +/- 3.0 AU/10 microg protein, P0.02) and nondiabetic cells (7.4 +/- 1.0 to 12.7 +/- 1.8, P0.05) were also upregulated by troglitazone treatment. Increased PPARgamma was associated with stimulation of human adipocyte lipid binding protein (ALBP) and muscle fatty acid binding protein (mFABP) mRNA, without change in the mRNA for glycerol-3-phosphate dehydrogenase, PPARdelta, myogenin, uncoupling protein-2, or sarcomeric alpha-actin protein. In summary, we showed that troglitazone markedly induces PPARgamma, ALBP, and mFABP mRNA abundance in muscle cultures from both nondiabetic and type II diabetic subjects. Increased expression of PPARgamma protein and other genes involved in glucose and lipid metabolism in skeletal muscle may account, in part, for the insulin sensitizing effects of troglitazone in type II diabetes.
Published: 1998

44. Troglitazone regulation of glucose metabolism in human skeletal muscle cultures from obese type II diabetic subjects

Author: K S, Park, T P, Ciaraldi, L, Abrams-Carter, S, Mudaliar, S E, Nikoulina, and R R, Henry
Subjects: Adult, Glucose Transporter Type 1, Monosaccharide Transport Proteins, Middle Aged, Thiazoles, Troglitazone, Glucose, Glycogen Synthase, Diabetes Mellitus, Type 2, Diabetes Mellitus, Humans, Hypoglycemic Agents, Insulin, Thiazolidinediones, Obesity, RNA, Messenger, Chromans, Muscle, Skeletal, Cells, Cultured
Abstract: To determine the effects of troglitazone on abnormal skeletal muscle glucose metabolism, muscle cultures from type II diabetic patients were grown for 4-6 weeks and then fused for 4 days either without or with troglitazone (1-5 micrograms/mL; chronic studies) or had troglitazone added for 90 min (1-5 micrograms/mL) at completion of fusion (acute studies). Acute troglitazone treatment stimulated glucose uptake, but not glycogen synthase (GS) activity 2-fold (P0.05) in a dose-dependent fashion and to the same extent as the addition of maximal (33 nmol/L) insulin. Maximal chronic troglitazone (5 micrograms/mL for 4 days) increased both glucose uptake (from 9.0 +/- 1.5 to 40.9 +/- 8.1 pmol/mg protein.min; P0.05) and GS fractional velocity (from 5.4 +/- 0.7% to 20.6 +/- 6.3%; P0.05) by approximately 4-fold. At each concentration of chronic troglitazone, glucose uptake rates were similar in the absence and presence of maximal (33 nmol/L) insulin concentrations. In contrast, insulin-stimulated GS activity was greater (P0.05) when maximal chronic troglitazone and acute insulin were combined than when chronic troglitazone alone was used. After 4 days of troglitazone, GLUT1 messenger ribonucleic acid and protein increased about 2-fold (P0.05) without a change in GLUT4 or GS messenger ribonucleic acid and protein. We conclude that troglitazone has both acute and chronic effects to improve skeletal muscle glucose metabolism of obese type II diabetic subjects. These effects involve direct insulin mimetic stimulatory actions as well as indirect insulin-sensitizing properties.
Published: 1998

45. Lack of effect of leptin on glucose transport, lipoprotein lipase, and insulin action in adipose and muscle cells

Author: S, Ranganathan, T P, Ciaraldi, R R, Henry, S, Mudaliar, and P A, Kern
Subjects: Leptin, Male, Mice, Obese, Proteins, Biological Transport, 3T3 Cells, Lipids, Cell Line, Rats, Rats, Sprague-Dawley, Lipoprotein Lipase, Mice, Glucose, Adipocytes, Animals, Humans, Insulin, Muscle, Skeletal
Abstract: The effect of leptin on glucose transport, lipogenesis, and lipoprotein lipase activity was studied in cultured rat adipocytes and 3T3-L1 adipocytes. Leptin had no effect on basal and insulin stimulated glucose transport in isolated adipocytes from the rat and the genetically obese mouse. The incorporation of glucose into lipids was also unaffected. Lipoprotein lipase (LPL) activity remained unchanged in response to leptin in these cells, as well as in minced adipose tissue. Leptin also had no effect on both basal and insulin-stimulated glucose transport in cultured rat and human skeletal muscle cells. These studies showed that leptin had no effect on glucose transport, lipoprotein lipase activity, and insulin action in fat and muscle cells in vitro.
Published: 1998

46. Shear flow instability in a partially-ionized plasma sheath around a fast-moving vehicle

Author: D. V. Rose, S. Mudaliar, T. C. Genoni, V.I. Sotnikov, Bryan V. Oliver, and Thomas Alan Mehlhorn
Subjects: Physics, Debye sheath, Acoustic wave, Plasma, Mechanics, Condensed Matter Physics, Ion acoustic wave, Instability, symbols.namesake, Shooting method, Two-stream instability, Physics::Plasma Physics, symbols, Atomic physics, Shear flow
Abstract: The stability of ion acoustic waves in a sheared-flow, partially-ionized compressible plasma sheath around a fast-moving vehicle in the upper atmosphere, is described and evaluated for different flow profiles. In a compressible plasma with shear flow, instability occurs for any velocity profile, not just for profiles with an inflection point. A second-order differential equation for the electrostatic potential of excited ion acoustic waves in the presence of electron and ion collisions with neutrals is derived and solved numerically using a shooting method with boundary conditions appropriate for a finite thickness sheath in contact with the vehicle. We consider three different velocity flow profiles and find that in all cases that neutral collisions can completely suppress the instability.
Published: 2011
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47. TOTAL RECONSTRUCTION OF THE VESICO-URETHRAL JUNCTION: TECHNIQUE FOR EARLY RETURN OF URINARY CONTINENCE IN PATIENTS UNDERGOING ROBOTIC PROSTATECTOMY

Author: E.D. Vaughan, S. Mudaliar, John A. Libertino, Jay Jhaveri, Sandhya Rao, A. Tewari, M. Pineda, E. Ioffe, Rajiv Yadav, N. Lang, A.E. Te, and G. Bartsch
Subjects: medicine.medical_specialty, Urinary continence, business.industry, Vesico urethral, Urology, medicine, In patient, Robotic prostatectomy, business
Published: 2008
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48. CONTINUOUS BASAL INSULIN INFUSION SIGNIFICANTLY REDUCES OXIDATIVE STRESS IN PATIENTS WITH TYPE 2 DIABETES

Author: P Theuma, V A Fonseca, C A Leissinger, S. Clejan, S Mudaliar, and R R Henry
Subjects: General Medicine, General Biochemistry, Genetics and Molecular Biology
Published: 2004
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49. Skeletal Muscle Glut1 Transporter Protein and Basal Leg Glucose Uptake is Reduced in Type 2 Diabetes

Author: T. P. Ciaraldi, S. Mudaliar, J. A. Macievic, A. Barzin, S. V. Edelman, K. P. Park, and R. R. Henry
Subjects: General Medicine, General Biochemistry, Genetics and Molecular Biology
Published: 2001
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50. Continuous Basal Insulin Infusion Significantly Reduces Oxidative Stress in Patients with Type 2 Diabetes

Author: P Theuma, VA Fonseca, CA Leissinger, S. Clejan, S Mudaliar, and RR Henry
Subjects: General Medicine, General Biochemistry, Genetics and Molecular Biology
Published: 2001
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