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In recent period of time, mankind has been giving more and more effort towards dietary supplements because now people are more concerned about their health. So, the availability and uses are also increased. For enhancing the frequency and effect of the dietary supplements, synthetic products like Phosphodiesterase Type 5 (PDE-5) Inhibitor, Cocaine, Fluoxetine, or some unwanted steroids are added to the supplements to enhance their market value. The consumption of these adulterated supplements has been linked to health problems and has had a negative impact on the quality and safety of dietary supplements as well as public health. To stop such dishonest practises, analytical techniques that enable quick and accurate testing of dietary supplements for the presence of synthetic drugs are required. For the determination of adulterated products in dietary supplements there are so many hyphenated techniques are available among all Gas Chromatography and Mass Spectrometry (GC-MS) is more specific and delicate because of its unique combination of Mass Spectrometry and Gas chromatography which helps in the field of Separation and structural identification of the adulterant. The role of GC-MS in the detection, quantification, conformation analysis of adulterants in dietary supplements is evaluated critically in the current review.

Herbal plants are marvelous source of traditional & modern medicine, useful for primary health care system globally. Herbal plants are also massive sources of neutraceuticals prevent the different disease and maintain healthy life style. The study of diseases and their treatment are important part of our ancient time worldwide. The awareness of medicinal plants must have been accumulated in the course of many centuries. Herbal medicine prepare different part of plant are used. Hygrophila difformis Blume is well known as water wisteria. It is tropical aquarium plant used as environmental ornaments. It is found in different part of India and Indian subcontinent including Bangladesh, Bhutan and Nepal. The plant is used as coagulant by tribal people of East Medinipur, dist West Bengal, India. The aerial part of the plant showed good anti-oxidant property, anthelmintic activity. Also ethanolic extract of aerial parts of the plant also showed CNS depressant activity. The main aims of this research are Preliminary physico– phytochemical & phytocognostical evaluation of the aerial parts of Hygrophila difformis Blume. The current study deals with the characterization of morphological features, determination of physical parameter such as the total ash value, water soluble ash, acid insoluble ash value were 14%, 5.25%, 6.81% respectively. Loss of drying was 13%, foaming index < 100, swelling index were 0.3cm, the percent yield for petroleum ether 3.29%, cyclo hexane 2.57% chloroform 1.99%, ethanol 9.15%, and aqueous 5.46%. Also determine the presence or absence of phytochemicals such as glycosides, tannins, steroids, flavonoids and saponins.

Two hydrogen-bonded crosslinked organic frameworks (HCOFs) were synthesized via free radical reactions utilizing butadiene and isoprene as crosslinkers. These HCOFs exhibit high crystallinity, enabling detailed structural characterization via single-crystal X-ray diffraction analysis. Subsequently, one of the olefin-rich HCOFs was converted to a hydroxylated framework through hydroboration–oxidation while maintaining the high crystallinity. [ABSTRACT FROM AUTHOR]

This study reports the synthesis of cofacial organic cage molecules containing aggregation‐induced emissive (AIE) luminogens (AIEgens) through four‐fold Cu(I)‐catalyzed azide–alkyne cycloaddition (CuAAC) "click" reactions. The shorter AIEgen, tetraphenylethylene (TPE), afforded two orientational isomers (TPE‐CC‐1A and TPE‐CC‐1B). The longer AIEgen, tetrabiphenylethylene (TBPE), afforded a single isomer (TBPE‐CC‐2). The click reaction employed is irreversible, yet it yielded remarkable four‐fold click products above 40 %. The phenyl rings around the ethylene core generate propeller‐shaped chirality owing to their orientation, which influences the chirality of the resulting cages. The shorter cages are a mixture of PP/MM isomers, while the longer ones are a mixture of PM/MP isomers, as evidenced by their x‐ray structures. The newly synthesized cage molecules are emissive even in dilute solutions (THF) and exhibit enhanced AIE upon the addition of water. The aggregated cage molecules in aqueous solution exhibit turn‐off emission sensing of nitroaromatic explosives, with selectivity to picric acid in the 25–38 nanomolar detection range. [ABSTRACT FROM AUTHOR]

Chiral self‐sorting during the formation of cage‐like molecules continues to fascinate and advance our understanding of the phenomenon in general. Herein, we report the chiral self‐sorting in the Pd6L12‐type metal‐organic cages. When a racemic mixture of axially chiral bis‐pyridyl ligands undergo coordination‐driven self‐assembly with Pd(II) ions to form Pd6L12‐type cages, the system has the option of chiral self‐sorting to afford any of at least 70 pairs of (one homochiral and 69 heterochiral) enantiomers and 5 meso isomers or a statistical mixture of everything. However, the system resulted in diastereoselective self‐assembly through a high‐fidelity chiral social self‐sorting to form a racemic mixture of D3 symmetric heterochiral [Pd6(L6R/6S)12]12+/[Pd6(L6S/6R)12]12+ cages. [ABSTRACT FROM AUTHOR]

The study of present research work is to be formulated and evaluate an herbal face pack for glowing skin by using natural herbalingredients. Everybody wants to get a fair and charming skin. Now a day, acne, black heads, pimples are common among persons who sufferfrom it. According to Ayurveda, skin problems are normally due to impurity in blood. Herbal ingredients Such as Multani mitti, Gram Flour, Rice flour, Lemon peel Powder, Manjishta, saffron, Turmeric, Aloe Vera, Milk powder were purchased from local market in theform of dried powder. All powdered natural ingredients were sieved using #120 mesh Particle size of the powder was found to be 20 -25µm., weighed accurately and mixed geometrically for uniform formulation and then evaluated for parameters including Organoleptic, physicochemical, physical, phytochemical, irritancy along with stability examination. The dried powder of combined form had passable flow property which is suitable for a face pack. In this study it is concluded that all the formulations of face packs found to be good in physical parameters, free from skin irritations so we found good properties forth face packs and further optimization studies are required on this study to find the useful benefits of face packs on human use as cosmetic product. [ABSTRACT FROM AUTHOR]

This work reports chiral social self-sorting in the diastereoselective self-assembly of Pd SB 6 sb L SB 12 sb metal-organic cages with a racemic mixture of axially chiral bis-pyridyl ligand with Pd(II) ions. Chiral self-sorting, chirality, coordination-driven self-assembly, metal-organic cages, self-assembly Keywords: chiral self-sorting; chirality; coordination-driven self-assembly; metal-organic cages; self-assembly EN chiral self-sorting chirality coordination-driven self-assembly metal-organic cages self-assembly 1 1 1 04/19/23 20230417 NES 230417 B The origin of chiral self-sorting b in the building blocks of life remains a fundamental question. [Extracted from the article]

This study reports the synthesis of cofacial organic cage molecules containing aggregation-induced emissive (AIE) luminogens (AIEgens) through four-fold Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) "click" reactions. The shorter AIEgen, tetraphenylethylene (TPE), afforded two orientational isomers (TPE-CC-1A and TPE-CC-1B). The longer AIEgen, tetrabiphenylethylene (TBPE), afforded a single isomer (TBPE-CC-2). The click reaction employed is irreversible, yet it yielded remarkable four-fold click products above 40 %. The phenyl rings around the ethylene core generate propeller-shaped chirality owing to their orientation, which influences the chirality of the resulting cages. The shorter cages are a mixture of PP/MM isomers, while the longer ones are a mixture of PM/MP isomers, as evidenced by their x-ray structures. The newly synthesized cage molecules are emissive even in dilute solutions (THF) and exhibit enhanced AIE upon the addition of water. The aggregated cage molecules in aqueous solution exhibit turn-off emission sensing of nitroaromatic explosives, with selectivity to picric acid in the 25-38 nanomolar detection range., (© 2023 Wiley-VCH GmbH.)

The ethanol extract of aerial parts of Hygrophila difformis (EEHD) was tested for possible pharmacological effects on experimental animals. EEHD significantly potentiated the sleeping time of mice induced by standard hypnotics, viz. pentobarbital sodium, diazepam, and meprobamate in a dose dependent manner. EEHD showed significant analgesic properties as evidenced by the significant reduction in the number of writhes and stretches induced in mice by 1.2% acetic acid solution. It also potentiated analgesia induced by morphine and pethidine in mice. Pretreatment with EEHD caused significant protection against strychnine and leptazol-induced convulsions. The behavioral studies on mice indicate CNS depressant activity of the ethanol extract of H. difformis.