Search

Relapse and metastasis occur in 30–40% of breast cancer patients, even after targeted treatments like trastuzumab for HER2-positive breast cancer. Accurate individual prognosis is essential for determining appropriate adjuvant treatment and early intervention. This study aims to enhance relapse and metastasis prediction using an innovative framework with machine learning (ML) and ensemble learning (EL) techniques. The developed framework is analyzed using The Cancer Genome Atlas (TCGA) data, which has 123 HER2-positive breast cancer patients. Our two-stage experimental approach first applied six basic ML models (support vector machine, logistic regression, decision tree, random forest, adaptive boosting, and extreme gradient boosting) and then ensembled these models using weighted averaging, soft voting, and hard voting techniques. The weighted averaging ensemble approach achieved enhanced performances of 88.46% accuracy, 89.74% precision, 94.59% sensitivity, 73.33% specificity, 92.11% F-Value, 71.07% Mathew’s correlation coefficient, and an AUC of 0.903. This framework enables the accurate prediction of relapse and metastasis in HER2-positive breast cancer patients using H&E images and clinical data, thereby assisting in better treatment decision-making.

Abstract Cancer has arisen from both genetic mutations and epigenetic changes, making epigenetics a crucial area of research for innovative cancer prevention and treatment strategies. This dual perspective has propelled epigenetics into the forefront of cancer research. This review highlights the important roles of DNA methylation, histone modifications and non-coding RNAs (ncRNAs), particularly microRNAs (miRNAs) and long non-coding RNAs, which are key regulators of cancer-related gene expression. It explores the potential of epigenetic-based therapies to revolutionize patient outcomes by selectively modulating specific epigenetic markers involved in tumorigenesis. The review examines promising epigenetic biomarkers for early cancer detection and prognosis. It also highlights recent progress in oligonucleotide-based therapies, including antisense oligonucleotides (ASOs) and antimiRs, to precisely modulate epigenetic processes. Furthermore, the concept of epigenetic editing is discussed, providing insight into the future role of precision medicine for cancer patients. The integration of nanomedicine into cancer therapy has been explored and offers innovative approaches to improve therapeutic efficacy. This comprehensive review of recent advances in epigenetic-based cancer therapy seeks to advance the field of precision oncology, ultimately culminating in improved patient outcomes in the fight against cancer.

Abstract Stroke prediction remains a critical area of research in healthcare, aiming to enhance early intervention and patient care strategies. This study investigates the efficacy of machine learning techniques, particularly principal component analysis (PCA) and a stacking ensemble method, for predicting stroke occurrences based on demographic, clinical, and lifestyle factors. We systematically varied PCA components and implemented a stacking model comprising random forest, decision tree, and K-nearest neighbors (KNN).Our findings demonstrate that setting PCA components to 16 optimally enhanced predictive accuracy, achieving a remarkable 98.6% accuracy in stroke prediction. Evaluation metrics underscored the robustness of our approach in handling class imbalance and improving model performance, also comparative analyses against traditional machine learning algorithms such as SVM, logistic regression, and Naive Bayes highlighted the superiority of our proposed method.

Abstract Background A thorough psychosocial assessment is time-consuming, often requiring multiple sessions to uncover the psychological factors contributing to mental illness, such as depression. The duration varies depending on the severity of the patient’s condition and how effectively the psychotherapist can establish rapport. However, prolonged assessment periods pose a significant risk of patient deterioration. Methods The comprehensive psychosocial intervention, led by the Multi-Criteria Decision-Making (MCDM) approach utilizing the Multi-Objective Optimization by Ratio Analysis (MOORA) method, played a pivotal role in identifying the key psychological factors contributing to the depression of the client among the 21 factors specified by BDI-II analysis. Results The integration of the MOORA strategy compared to traditional psychotherapy on 254 samples demonstrates a Jaccard similarity coefficient of 0.8, with a minimum error margin of 7% (vulnerability index = 0.57), indicating a significant agreement between the two approaches, both converging towards a similar solution. For patients with extreme depression, the number of sessions reduced from 18 ± 2 to 11 ± 2, showing a 33–35% reduction (χ 2 = 6.94, p = 0.008). Severe depression patients experienced a reduction from 14 ± 2 to 8 ± 1 sessions i.e., 34–39% reduction (χ 2 = 8.32, p = 0.004). Moderate depression patients saw sessions drop from 9 ± 1 to 5 ± 1, i.e., 37–43% reduction (χ 2 = 0.29, p = 0.001). The accuracy for detecting dominant psychological factors improved to 82.88% for extreme, 86.74% for severe, and 90.34% for moderate depression, respectively. Conclusion The implementation of MOORA facilitated the identification and prioritization of key psychosocial intervention strategies, making the process significantly faster compared to traditional methods. This acceleration greatly enhanced the precision and efficacy of the work. Additionally, critical vulnerable factors were identified through ordered statistics and correlation analysis [Pearson (r) = 0.8929 and Spearman’s rank (ρ) = 0.7551] on the Beck Depression Inventory-II model. These findings were supported by other MCDM schemes such as EDAS and TOPSIS, demonstrating high stability and robustness in dynamic decision-making environments, maintaining consistency across scenarios adapted by different psychotherapists. Overall, the combined application of MCDM (MOORA) and targeted psychological interventions yielded substantial positive outcomes in enhancing the well-being of individuals with psychological illnesses, such as depression, cognitive, affective, and somatic syndromes.

Abstract Background Several computational and mathematical models of protein synthesis have been explored to accomplish the quantitative analysis of protein synthesis components and polysome structure. The effect of gene sequence (coding and non-coding region) in protein synthesis, mutation in gene sequence, and functional model of ribosome needs to be explored to investigate the relationship among protein synthesis components further. Ribosomal computing is implemented by imitating the functional property of protein synthesis. Result In the proposed work, a general framework of ribosomal computing is demonstrated by developing a computational model to present the relationship between biological details of protein synthesis and computing principles. Here, mathematical abstractions are chosen carefully without probing into intricate chemical details of the micro-operations of protein synthesis for ease of understanding. This model demonstrates the cause and effect of ribosome stalling during protein synthesis and the relationship between functional protein and gene sequence. Moreover, it also reveals the computing nature of ribosome molecules and other protein synthesis components. The effect of gene mutation on protein synthesis is also explored in this model. Conclusion The computational model for ribosomal computing is implemented in this work. The proposed model demonstrates the relationship among gene sequences and protein synthesis components. This model also helps to implement a simulation environment (a simulator) for generating protein chains from gene sequences and can spot the problem during protein synthesis. Thus, this simulator can identify a disease that can happen due to a protein synthesis problem and suggest precautions for it.

Abstract It has become increasingly difficult for medical practitioners to recognize illness in recent years due to the emergence of new diseases from their myriad causes on a daily basis. Due in large part to inadequate diagnostic and monitoring infrastructure, a substantial amount of illness and death are associated with lung cancer (LC). The aim of the paper is to find lung cancer early and help patients receive curative treatment. Quitting smoking or never starting is the best way to mitigate the potential for disease-related death. As a result, cutting-edge detection and monitoring technologies must be developed to enable rapid, accurate, and timely diagnosis. Fuzzy logic (FL) is one of the best approaches to modeling complex and uncertain systems; therefore, it helps us deal with these challenges. Fuzzy expert system for lung cancer [FES-LC] detection and prediction on Internet of medical things (IoMT) is employed to overcome the challenges. Hence, an enhanced adaptive neuro-fuzzy inference framework [ANF-IF] is proposed in the current research. The cloud-based application of an adaptive neuro-fuzzy inference system yields four risk categories: not at risk, slightly at risk, moderately at risk, and severely at risk. New methods and theoretical frameworks have made it possible to diagnose LC in its earliest stages with the help of magnetic nanoparticles (MNPs), which allow researchers to overcome the limitations of conventionally slow diagnostic efficiency. The proposed system exhibits a precision of 93.4%, accuracy of 95.1%, specificity of 90.6%, sensitivity of 92.8%, false positive rate of 0.22%, false negative ratio of 0.18%, and classification accuracy of 98.2%. The proposed method outperforms all methods and provides better lung cancer detection accuracy than others.

Abstract Background Long non-coding RNAs (lncRNAs) are RNA transcripts of more than 200 nucleotides that do not encode canonical proteins. Their biological structure is similar to messenger RNAs (mRNAs). To distinguish between lncRNA and mRNA transcripts quickly and accurately, we upgraded the PLEK alignment-free tool to its next version, PLEKv2, and constructed models tailored for both animals and plants. Results PLEKv2 can achieve 98.7% prediction accuracy for human datasets. Compared with classical tools and deep learning-based models, this is 8.1%, 3.7%, 16.6%, 1.4%, 4.9%, and 48.9% higher than CPC2, CNCI, Wen et al.’s CNN, LncADeep, PLEK, and NcResNet, respectively. The accuracy of PLEKv2 was > 90% for cross-species prediction. PLEKv2 is more effective and robust than CPC2, CNCI, LncADeep, PLEK, and NcResNet for primate datasets (including chimpanzees, macaques, and gorillas). Moreover, PLEKv2 is not only suitable for non-human primates that are closely related to humans, but can also predict the coding ability of RNA sequences in plants such as Arabidopsis. Conclusions The experimental results illustrate that the model constructed by PLEKv2 can distinguish lncRNAs and mRNAs better than PLEK. The PLEKv2 software is freely available at https://sourceforge.net/projects/plek2/ .

Abstract In this work, we use two unique methodologies, the homotopy perturbation transform method and Yang transform decomposition method, to solve the fractional nonlinear seventh-order Kaup–Kupershmidt (KK) problem. The physical phenomena that arise in chemistry, physics, and engineering are mathematically explained in this equation, in particular, nonlinear optics, quantum mechanics, plasma physics, fluid dynamics, and so on. The provided methods are used to solve the fractional nonlinear seventh-order KK problem along with the Yang transform and fractional Caputo derivative. The results are significant and necessary for exploring a range of physical processes. This paper uses modern approaches and the fractional operator to develop satisfactory approximations to the offered problem. To solve the fractional KK equation, we first use the Yang transform and fractional Caputo derivative. He’s and Adomian polynomials are useful to manage nonlinear terms. It is shown that the suggested approximate solution converges to the exact one. In these approaches, the results are calculated as convergent series. The key advantage of the recommended approaches is that they provide highly precise results with little computational work. The suggested approach results are compared to the precise solution. By comparing the outcomes with the precise solution using graphs and tables we can verify the efficacy of the offered strategies. Also, the outcomes of the suggested methods at various fractional orders are examined, demonstrating that the findings get more accurate as the value moves from fractional order to integer order. Moreover, the offered methods are innovative, simple, and quite accurate, demonstrating that they are effective for resolving differential equations.

Abstract Technology offers a lot of potential that is being used to improve the integrity and efficiency of infrastructures. Crack is one of the major concerns that can affect the integrity or usability of any structure. Oftentimes, the use of manual inspection methods leads to delays which can worsen the situation. Automated crack detection has become very necessary for efficient management and inspection of critical infrastructures. Previous research in crack detection employed classification and localization-based models using Deep Convolutional Neural Networks (DCNNs). This study suggests and compares the effectiveness of transfer learned DCNNs for crack detection as a classification model and as a feature extractor to overcome this restriction. The main objective of this paper is to present various methods of crack detection on surfaces and compare their performance over 3 different datasets. Experiments conducted in this work are threefold: initially, the effectiveness of 12 transfer learned DCNN models for crack detection is analyzed on three publicly available datasets: SDNET, CCIC and BSD. With an accuracy of 53.40%, ResNet101 outperformed other models on the SDNET dataset. EfficientNetB0 was the most accurate (98.8%) model on the BSD dataset, and ResNet50 performed better with an accuracy of 99.8% on the CCIC dataset. Secondly, two image enhancement methods are employed to enhance the images and are transferred learned on the 12 DCNNs in pursuance of improving the performance of the SDNET dataset. The results from the experiments show that the enhanced images improved the accuracy of transfer-learned crack detection models significantly. Furthermore, deep features extracted from the last fully connected layer of the DCNNs are used to train the Support Vector Machine (SVM). The integration of deep features with SVM enhanced the detection accuracy across all the DCNN-dataset combinations, according to analysis in terms of accuracy, precision, recall, and F1-score.

Abstract Parkinson's disease (PD) is challenging for clinicians to accurately diagnose in the early stages. Quantitative measures of brain health can be obtained safely and non-invasively using medical imaging techniques like magnetic resonance imaging (MRI) and single photon emission computed tomography (SPECT). For accurate diagnosis of PD, powerful machine learning and deep learning models as well as the effectiveness of medical imaging tools for assessing neurological health are required. This study proposes four deep learning models with a hybrid model for the early detection of PD. For the simulation study, two standard datasets are chosen. Further to improve the performance of the models, grey wolf optimization (GWO) is used to automatically fine-tune the hyperparameters of the models. The GWO-VGG16, GWO-DenseNet, GWO-DenseNet + LSTM, GWO-InceptionV3 and GWO-VGG16 + InceptionV3 are applied to the T1,T2-weighted and SPECT DaTscan datasets. All the models performed well and obtained near or above 99% accuracy. The highest accuracy of 99.94% and AUC of 99.99% is achieved by the hybrid model (GWO-VGG16 + InceptionV3) for T1,T2-weighted dataset and 100% accuracy and 99.92% AUC is recorded for GWO-VGG16 + InceptionV3 models using SPECT DaTscan dataset.

Abstract Background Dental pathogens play a crucial role in oral health issues, including tooth decay, gum disease, and oral infections, and recent research suggests a link between these pathogens and oral cancer initiation and progression. Innovative therapeutic approaches are needed due to antibiotic resistance concerns and treatment limitations. Methods We synthesized and analyzed piperine-coated zinc oxide nanoparticles (ZnO-PIP NPs) using UV spectroscopy, SEM, XRD, FTIR, and EDAX. Antioxidant and antimicrobial effectiveness were evaluated through DPPH, ABTS, and MIC assays, while the anticancer properties were assessed on KB oral squamous carcinoma cells. Results ZnO-PIP NPs exhibited significant antioxidant activity and a MIC of 50 µg/mL against dental pathogens, indicating strong antimicrobial properties. Interaction analysis revealed high binding affinity with dental pathogens. ZnO-PIP NPs showed dose-dependent anticancer activity on KB cells, upregulating apoptotic genes BCL2, BAX, and P53. Conclusions This approach offers a multifaceted solution to combatting both oral infections and cancer, showcasing their potential for significant advancement in oral healthcare. It is essential to acknowledge potential limitations and challenges associated with the use of ZnO NPs in clinical applications. These may include concerns regarding nanoparticle toxicity, biocompatibility, and long-term safety. Further research and rigorous testing are warranted to address these issues and ensure the safe and effective translation of ZnO-PIP NPs into clinical practice.

Life has become more comfortable in the era of advanced technology in this cutthroat competitive world. However, there are also emerging harmful technologies that pose a threat. Without a doubt, phishing is one of the rising concerns that leads to stealing vital information such as passwords, security codes, and personal data from any target node through communication hijacking techniques. In addition, phishing attacks include delivering false messages that originate from a trusted source. Moreover, a phishing attack aims to get the victim to run malicious programs and reveal confidential data, such as bank credentials, one-time passwords, and user login credentials. The sole intention is to collect personal information through malicious program-based attempts embedded in URLs, emails, and website-based attempts. Notably, this proposed technique detects URL, email, and website-based phishing attacks, which will be beneficial and secure us from scam attempts. Subsequently, the data are pre-processed to identify phishing attacks using data cleaning, attribute selection, and attacks detected using machine learning techniques. Furthermore, the proposed techniques use heuristic-based machine learning to identify phishing attacks. Admittedly, 56 features are used to analyze URL phishing findings, and experimental results show that the proposed technique has a better accuracy of 97.2%. Above all, the proposed techniques for email phishing detection obtain a higher accuracy of 97.4%. In addition, the proposed technique for website phishing detection has a better accuracy of 98.1%, and 48 features are used for analysis.

Wireless Sensor Networks (WSNs) an energy consumption is a significant problematic due to the limited power resources of sensor nodes. Mobile Sinks (MS) rise the system's flexibility and convenience of data collection. The important role of Load balancing techniques plays in extending network lifetime by uniformly spreading energy usage between sensor nodes. WSN Data Collection for Two-Phase Energy Minimized Load Balancing Scheme (TPEMLB) with Sequential Convex Approximation (SCA), the use of a movable sink, is discovered in this research. The MS collects data from nearby sensors called as sub-sinks along a path as it moves. Data collection throughput is enhanced through efficient data distribution among sub-sinks and a data collection schedule. Geometric programming and SCA methods make an algorithm with guaranteed convergence to meet the problematic task. This research employs a SCA method to discover the best locations for sensor nodes while keeping energy restrictions in mind. Using a series of convex optimization difficulties, this technique repeatedly estimates the optimal sensor node positions that minimize energy consumption while ensuring sufficient coverage of the target region. In the second stage, incorporate a mobile drain that traverses the network intelligently to collect data from sensor nodes. The technique considers sensor node energy levels, data collection rates, and distance from the receptacle to balance network traffic and decrease energy consumption. Subsequently, the proposed model TPEMLB has a higher deployment success rate and efficiency, a more extended network lifetime, lower energy consumption, and better load balancing, and is the preferred solution for the unique challenge.

The goal of the current study is to analyze several nonlinear two-dimensional time-fractional Rosenau–Hyman equations. The two-dimensional fractional Rosenau–Hyman equation has extensive use in engineering and applied sciences. The fractional view analysis of two-dimensional time-fractional Rosenau–Hyman equations is discussed using the homotopy perturbation approach, Adomian decomposition method, and Yang transformation. Some examples involving two-dimensional time-fractional Rosenau–Hyman equations are provided to better understand the suggested approaches. The solutions appear as infinite series. We offer a comparison between the accurate solutions and those that are generated employing the proposed approaches to demonstrate the effectiveness and applicability of the proposed techniques. The results are graphically illustrated using two-dimensional and three-dimensional graphs. It has been noted that the obtained results and the targeted problems real solutions are quite similar. Calculated solutions at various fractional levels describe some of the problems useful dynamics. A comparison between the numerical solutions of the models under study and the exact solutions in cases when a solution is known serves as a clear demonstration of the viability and dependability of the suggested approaches. Other fractional problems that arise in other fields of science and engineering can be solved using a modified version of the current techniques.

The surge in Distributed Denial of Service (DDoS) attacks within SDN environments demands more potent defense strategies. While Moving Target Defense (MTD) holds promise, current MTD approaches against DDoS suffer from security gaps due to overwhelming malicious traffic and static detection areas. In order to tackle these difficulties, we have implemented BSDN-HMTD, a combination of deep learning and blockchain technologies within SDN environments, as a framework. Our strategy starts by employing blockchain technology to authenticate users. We use the NTRU-based Nyberg Rueppel Digital Signature Algorithm for this purpose. This ensures that only authenticated user flows are allowed for validation and forwarding. Within the forwarding layer, Quantum Convolutional Neural Networks (QCNN) evaluate authentic flows by analyzing many characteristics, effectively differentiating between regular, malicious, and dubious flows. Utilizing an Enhanced Spotted Hyena Optimization (EHSO) method to activate switches in real-time modifies the vulnerable points of attack, so impeding attackers and simultaneously decreasing energy usage. The Forwarding Layer Organizer (FLO) oversees the detection of possible attacker surveillance activities and transmits the collected information to local controllers in the control layer. The controllers, functioning in a structured controller network, carry out proactive Moving Target Defense (MTD) techniques, such as host virtual IP hopping, which make attacker plans more complex and raise their operational expenses. Reactive MTD actions are implemented based on the results of flow validation. These actions utilize techniques such as secure honeypots and host virtual IP hopping to effectively prevent attacks. The blockchain securely logs all processed data related to packet validation, authentication, and honeypot activities to ensure the protection of data privacy. Our studies, conducted using Network Simulator-3.26 (NS-3.26), show that our proposed framework outperforms existing techniques in terms of several validation criteria.

Abstract Background Lung cancer is the second most common cancer worldwide, with over two million new cases per year. Early identification would allow healthcare practitioners to handle it more effectively. The advancement of computer-aided detection systems significantly impacted clinical analysis and decision-making on human disease. Towards this, machine learning and deep learning techniques are successfully being applied. Due to several advantages, transfer learning has become popular for disease detection based on image data. Methods In this work, we build a novel transfer learning model (VER-Net) by stacking three different transfer learning models to detect lung cancer using lung CT scan images. The model is trained to map the CT scan images with four lung cancer classes. Various measures, such as image preprocessing, data augmentation, and hyperparameter tuning, are taken to improve the efficacy of VER-Net. All the models are trained and evaluated using multiclass classifications chest CT images. Results The experimental results confirm that VER-Net outperformed the other eight transfer learning models compared with. VER-Net scored 91%, 92%, 91%, and 91.3% when tested for accuracy, precision, recall, and F1-score, respectively. Compared to the state-of-the-art, VER-Net has better accuracy. Conclusion VER-Net is not only effectively used for lung cancer detection but may also be useful for other diseases for which CT scan images are available.

Abstract The article introduces a revolutionary Nanorouter structure, which is a crucial component in the Nano communication regime. To complete the connection, many key properties of Nanorouters are investigated and merged. QCA circuits with better speed and reduced power dissipation aid in meeting internet standards. Cryptography based on QCA design methodologies is a novel concept in digital circuit design. Data security in nano-communication is crucial in data transmission and reception; hence, cryptographic approaches are necessary. The data entering the input line is encrypted by an encoder, and then sent to the designated output line, where it is decoded and transferred. The Nanorouter is offered as a data path selector, and the proposed study analyses the cell count of QCA and the circuit delay. In this manuscript, novel designs of (4:1)) Mux and (1:4) Demux designs are utilized to implement the proposed nanorouter design. The proposed (4:1) Mux design requires 3–5% fewer cell counts and 20–25% fewer area, and the propsoed (1:4) Demux designs require 75–80% fewer cell counts and 90–95% fewer area compared to their latest counterparts. The QCAPro utility is used to analyse the power consumption of several components that make up the router. QCADesigner 2.0.3 is used to validate the simulation results and output validity.

Abstract Extensive research is now being conducted on the design and construction of logic circuits utilizing quantum-dot cellular automata (QCA) technology. This area of study is of great interest due to the inherent advantages it offers, such as its compact size, high speed, low power dissipation, and enhanced switching frequency in the nanoscale domain. This work presents a design of a highly efficient RAM cell in QCA, utilizing a combination of a 3-input and 5-input Majority Voter (MV) gate, together with a 2 × 1 Multiplexer (MUX). The proposed design is also investigated for various faults such as single cell deletion, single cell addition and single cell displacement or misalignment defects. The circuit under consideration has a high degree of fault tolerance. The functionality of the suggested design is showcased and verified through the utilization of the QCADesigner tool. Based on the observed performance correlation, it is evident that the proposed design demonstrates effectiveness in terms of cell count, area, and latency. Furthermore, it achieves a notable improvement of up to 76.72% compared to the present configuration in terms of quantum cost. The analysis of energy dissipation, conducted using the QCAPro tool, is also shown for various scenarios. It is seen that this design exhibits the lowest energy dispersion, hence enabling the development of ultra-low power designs for diverse microprocessors and microcontrollers.

Abstract Biological systems can gain complexity over time. While some of these transitions are likely driven by natural selection, the extent to which they occur without providing an adaptive benefit is unknown. At the molecular level, one example is heteromeric complexes replacing homomeric ones following gene duplication. Here, we build a biophysical model and simulate the evolution of homodimers and heterodimers following gene duplication using distributions of mutational effects inferred from available protein structures. We keep the specific activity of each dimer identical, so their concentrations drift neutrally without new functions. We show that for more than 60% of tested dimer structures, the relative concentration of the heteromer increases over time due to mutational biases that favor the heterodimer. However, allowing mutational effects on synthesis rates and differences in the specific activity of homo- and heterodimers can limit or reverse the observed bias toward heterodimers. Our results show that the accumulation of more complex protein quaternary structures is likely under neutral evolution, and that natural selection would be needed to reverse this tendency.

Abstract In this paper, NeuralProphet (NP), an explainable hybrid modular framework, enhances the forecasting performance of pandemics by adding two neural network modules; auto-regressor (AR) and lagged-regressor (LR). An advanced deep auto-regressor neural network (Deep-AR-Net) model is employed to implement these two modules. The enhanced NP is optimized via AdamW and Huber loss function to perform multivariate multi-step forecasting contrast to Prophet. The models are validated with COVID-19 time-series datasets. The NP’s efficiency is studied component-wise for a long-term forecast for India and an overall reduction of 60.36% and individually 34.7% by AR-module, 53.4% by LR-module in MASE compared to Prophet. The Deep-AR-Net model reduces the forecasting error of NP for all five countries, on average, by 49.21% and 46.07% for short-and-long-term, respectively. The visualizations confirm that forecasting curves are closer to the actual cases but significantly different from Prophet. Hence, it can develop a real-time decision-making system for highly infectious diseases.

The study presents a novel method to improve the prediction accuracy of cardiac disease by combining data augmentation techniques with reinforcement learning. The complex nature of cardiac data frequently presents challenges for traditional machine learning models, which results in subpar performance. In response, our fusion methodology improves predictive capabilities by augmenting data and utilizing reinforcement learning's skill at sequential decision-making. Our method predicts cardiac disease with an astounding 94 % accuracy rate, which is an outstanding result. This significant improvement outperforms existing techniques and shows a deeper comprehension of intricate data relationships. The amalgamation of reinforcement learning and data augmentation not only yields superior predictive accuracy but also bears noteworthy consequences for patient care and accurate cardiac diagnosis. Through the efficient combination of these approaches, our method provides a powerful response to the difficulties presented by complicated cardiac data. The potential to transform illness prediction and prevention techniques and ultimately improve patient outcomes is demonstrated by this integration's success.

The rapid identification and categorisation of breast cancers using low-contrast MRI images presents a significant challenge due to the disease’s prevalence among women of all ages. Nowadays, it is very difficult to classify and generalise models from low-contrast MRI datasets due to the prevalence of class imbalance caused by a wide range of symptoms and untrustworthy data sources. Using ensemble learning with optimised k-means helps with these problems; it reduces overfitting and improves reliability by using methods like k-means clustering, frog feap algorithm (FLA), boosting, and bagging to balance datasets and show the complexity of symptoms. In this research, we present a new strategy that makes use of a hybrid optimised K-Means algorithm combined with the FLA, along with thresholding and morphological approaches, and ensemble learning. There are two main stages to our work. In the initial phase, we preprocess low-contrast MRI images and delineate the breast tumour area from the segmented MRI images. Furthermore, we employ Discrete Wavelet Transformation (DWT) to extract the most salient features. In the next step, the retrieved features will be used as input parameters for an ensemble-learned breast tumour classifier. To determine whether a low-contrast breast tumour MRI picture has a benign or malignant tumour after model training, we use a variety of classifiers, such as k-nearest neighbours (KNN), decision trees (DT), gradient boosting (GB), random forests (RF), and artificial neural networks (ANN). Through a voting mechanism that averages the accuracy of all models, our suggested framework achieves a remarkable 98.8% accuracy rate. In addition, proposed model is quite efficient & reliable to detect the kind of breast tumour or cancer with a sensitivity of 98.02% and a specificity of 97.5%.

Cancer remains one of the leading causes of mortality worldwide, necessitating continuous advancements in early diagnosis and treatment. Deep learning, a subset of artificial intelligence, has emerged as a powerful tool in the field of medical image analysis, revolutionizing the way cancer is detected and diagnosed. The study discusses the various modalities employed in lung cancer diagnosis, such as medical imaging (e.g., radiology and pathology), genomics, and clinical data, highlighting the unique challenges associated with each domain. The proposed Multimodal Fusion Deep Neural Network (MFDNN) architecture design effectively integrates information from different modalities (e.g., medical imaging, genomics, clinical data) to enhance lung cancer diagnostic accuracy. Furthermore, it delves into the integration of clinical data, electronic health records, and multimodal approaches to improve the accuracy and reliability of lung cancer diagnosis. Moreover, we highlight the ethical considerations surrounding the deployment of Artificial Intelligence (AI) in clinical settings and the need for robust validation and regulatory guidelines. The Multimodal Fusion Deep Neural Network (MFDNN) achieves an exceptional accuracy rate of 92.5 %, marking a significant breakthrough in the realm of medical AI. MFDNN excels in precision, with 87.4 % accuracy in predicting cancer cases, and equally impresses in recall, capturing approximately 86.4 % of actual cancerous cases. The F1-score of 86.2 further exemplifies MFDNN's ability to strike a harmonious equilibrium, ensuring both diagnostic accuracy and minimized missed diagnoses. The performance is compared with established methods like CNN, DNN, and ResNet. The results underscore MFDNN's pivotal role in revolutionizing lung cancer diagnosis, promising more accurate and timely identification of this critical condition.

This research presents a process for analyzing a hybrid microgrid's dependability using a fuzzy Markov model. The research initiated an analysis of the various microgrid components, such as wind power systems, solar photovoltaic (PV) systems, and battery storage systems. The states that are induced by component failures are represented using a state-space model. The research continues by suggesting a hybrid microgrid reliability model that analyzes data using a Markov process. Problems arise when trying to estimate reliability metrics for the microgrid using data that is both restricted and imprecise. This is why the study takes uncertainties into account to make microgrid reliability estimations more realistic. The importance of microgrid components concerning their overall availability is evaluated using fuzzy sets and reliability assessments. The study uses numerical analysis and then carefully considers the outcomes. The overall availability of hybrid microgrids is 0.99999.

In this article, we present dielectric modulation-based label free detection of biomolecules at a cavity under gate metal located near the tunneling junction of charge plasma based dual metal-double gate tunnel FET (CP-DM DGTFET). The biomolecules that settle down in the cavity act as dielectric above the tunneling junction and cause drain current to increase/ decrease. To eliminate the short channel impact and to enhance ION/IOFF ratio without compromising any other device features, dual metal gate architecture with laterally split dielectric is used. The biosensor is capable of recognizing neutral, positive, and negative charges with the highest drain current sensitivity of $2.9\times 10 ^{9}$ Ccm-2 and highest ION/IOFF ratio of $9.02\times 10 ^{11}$ for biomolecule gelatin with dielectric constant k =12. This work explores the effectiveness of charge-plasma based DM DGTFET for detection of biomolecules such as gelatin (k =12), keratin (k =8), bacteriophage T7 (k =6.3), and APTES (k =3.57) with varied charge distribution at various biasing. The drain current sensitivity, subthreshold slope, drain current, ON/OFF current ratio are computed for various biomolecules and their variations with respect to cavity length, biomolecule charge, etc. are used to detect unknown biomolecules. Finally, RF analysis such as gain bandwidth product, cut-off frequency, transit time, and linearity/selectivity of biosensors are incorporated. The device shows better linearity and less distortion for high –k biomolecules. The results of our studies are reproducible for repeated computed analysis.

Air pollution is a critical global concern, demanding precise air quality forecasting to mitigate its severe consequences. Our study introduces Future Air Quality Prediction using Long Short-Term Memory based on Hyper Heuristic Multi-Chain Model (H2MCM) to project future air quality, considering various meteorological factors (MFs) and pollution-related variables like atmospheric pressure, temperature, humidity, and wind patterns. Leveraging 12 units of Long Short-Term Memory neural networks (LSTMs), H2MCM accurately predicts forthcoming air pollutants (APs) concentrations such as particulate matter with diameter $2.5 \; \mu $ m (PM2.5), carbon monoxide (CO), and nitrogen dioxide (NO2). Additionally, it accounts for spatiotemporal correlations between these APs and MFs, which significantly influence the air quality prediction for the next immediate time interval. H2MCM utilizes a multi-chain mechanism, employing 1-hour prediction models to forecast air quality hourly, enabling approximations for the next 12 hours. Also, for an efficient model selection, Akaike Information Criterion (AIC), Schwarz Bayesian Information Criterion (SBIC), Hannan-Quinn Information Criterion (HQIC), and corrected AIC (AICc) tools are used based on their ability to balance model fit and complexity. Furthermore, it demonstrates the ability to enhance the performance of any predictor. Experimental results substantiate H2MCM’s superiority over various models, including the Support Vector Regressor (SVR), Multi-Layer Perceptron (MLP), Recurrent Air Quality Predictor (RAQP), and Valchogianni models. H2MCM achieves impressive up to 75% better accuracy and consistency compared to SVR, 60% better than MLP, 38% better than RAQP, and 70% better than Valchogianni models.

In the paradigm of Device-to-Device (D2D) and System-on-Chip (SoC) communications, the optimization of high-speed data transfer while minimizing hardware resource utilization imposing paramount importance. Traditional methodologies have often resulted in undesirable outcomes, such as inflated area, latency, and power consumption. Consequently, this study adopts a focused approach by introducing an innovative Route-Controlling Network-on-Chip (RC-NoC) architecture, integrating critical components like FIFO-Buffer, crossbar switching, route control, and arbiter modules. The operational sequence begins with the FIFO-Buffer logic, which strategically manages data storage from diverse devices, allocating and organizing data flow based on distinct IP addresses. Subsequently, the route controller module orchestrates the operation of heterogeneous routers within the crossbar switching fabric, implementing a prioritized scheduling scheme. The arbiter plays a crucial role in overseeing and directing data flow from source to destination, leveraging request-level prioritization for efficient data transmission. Empirical evidence from simulations unequivocally demonstrates the superiority of the proposed RC-NoC architecture. Comparative analysis against essential state-of-the-art NoC architectures reveals significant enhancements in key metrics, notably area efficiency, latency reduction, and power optimization, with over 45% improvement observed across these metrics compared to GALS-NoC, F-NoC, and CE-NoC in the Orion framework. This robust validation substantiates the efficacy and technical prowess of the RC-NoC design paradigm in addressing the challenges of modern D2D and SoC communication paradigms. Furthermore, the optimization process notably decreased routing costs for different packets, with Router2 exhibiting a 40% reduction in Packet1’s routing cost and Router3 displaying a 44% decrease in Packet2’s cost. Moreover, the attained router capacities demonstrated an average increase of 17%, significantly enhancing network efficiency.

The paper investigates the terahertz performance of a mutually injection-locked multi-element high electron mobility avalanche transit time (HEM-ATT) source based on AlGaN/GaN two-dimensional electron gas (2-DEG). Utilizing a nanostrip patch type planar coupling circuit, mutual injection locking between adjacent elements is achieved. The paper provides a comprehensive analysis of the integrated power combining technique in the mutually injection-locked multi-element HEM-ATT oscillator. A ten-element mutually injection-locked integrated power combined source is designed for operation at 1.0 THz, and simulation studies are conducted to examine its DC, large-signal, and avalanche noise characteristics. The capability of generating a narrow-band terahertz wave is verified by introducing various levels of structural mismatches between the elements. Results indicate that the ten-element HEM-ATT oscillator can deliver 2.27 W peak power with a 17% DC to THz conversion efficiency at 1.0 THz. The average noise measure of the oscillator is found to be 12.54 dB. Additionally, the terahertz performance of the mutually injection-locked ten-element HEM-ATT oscillator is compared with other state-of-the-art THz sources to evaluate its potentiality as an excellent integrated THz radiator.

The Smart City (SC) framework has garnered global recognition for its transformative influence on society through innovative solutions. However, the extensive use of Internet of Things (IoT) devices in SCs raises concerns regarding electronic waste and resource consumption. Addressing this challenge necessitates integrating smart grid systems to safeguard SC residents’ environment and well-being. Accurate air quality prediction is essential for informed societal decisions, safe transportation, and disaster preparedness. This study introduces a novel approach: Towards Cleaner Industries: Smart Cities’ Impact on Predictive Air Quality Management (SPAM). The SPAM model utilizes a bidirectional stacking mechanism of long short-term memory neural networks, considering spatiotemporal correlations to forecast future air pollutant concentrations. Surpassing conventional methods, SPAM model enhances accuracy while reducing computational complexity. Experimental findings demonstrate enhanced efficiency and accuracy, underscoring its practicality in industrial contexts. The SPAM model represents a significant advancement in promoting environmental sustainability within the SC framework.

The device dimension down scaling beyond 14 nm technology node utilization of device architecture and new materials is a need of the semiconductors industry. In this paper, three materials, In $_{\mathrm {1-x}}$ GaxAs/ In $_{\mathrm {1-x}}$ GaxP, In $_{1-}$ xGax GAA JL FET developed and analyzed for their analog performance at high temperature. In $_{\mathrm {1-x}}$ GaxAs has a composition of 53% InAs and 47% GaAs with a band gap of 0.75 eV, whereas In $_{\mathrm {1-x}}$ GaxP and In $_{\mathrm {1-x}}$ GaxN exhibit a wider band gap of 1.90 eV and 3.2 eV, respectively, and exhibit different analog performance. An analytical model that is temperature-dependent for the drain current of In $_{\mathrm {1-x}}$ GaxAs, In $_{\mathrm {1-x}}$ GaxP, In $_{\mathrm {1-x}}$ GaxN GAA JL FET with mobility variations has also been developed. The ratio of transconductance-to-normalized drain current (gm/I $_{\mathrm {DS}}$ ) is utilized to examine analog properties. This ratio is a crucial measure of analog performance since it reveals the sensitivity and linearity of the device. All device parameters such as transconductance (g $_{\mathrm {m}}$ ), gm/IDS, cut-off frequency, and intrinsic gain were investigated for higher temperatures ranging from T =300 K to T =500 K. The newly developed device parameters have very low-temperature sensitivity, making these three material devices potential candidates for high temperature applications.

Tunicate Swarm Algorithm (TSA) is a novel swarm intelligence algorithm developed in 2020. Though it has shown superior performance in numerical benchmark function optimization and six engineering design problems over its competitive algorithms, it still needs further improvements. This article proposes two improved TSA algorithms using chaos theory, opposition-based learning (OBL) and Cauchy mutation. The proposed algorithms are termed OCSTA and COCSTA. The static and dynamic OBL are used respectively in the initialization and generation jumping phase of OCTSA, whereas centroid opposition-based computing is used, in the same phases, in COCTSA. The proposed algorithms are tested on 30 IEEE CEC2017 benchmark optimization problems consists of unimodal, multimodal, hybrid, and composite functions with 30, 50, and 100 dimensions. The experimental results are compared with the classical TSA, TSA with the local escaping operator (TSA-LEO), Sine Cosine Algorithm (SCA), Giza-Pyramid Construction Algorithm (GPC), Covariance Matrix Adaptation Evolution Strategy (CMAES), Archimedes Optimization Algorithm (AOA), Opposition-Based Arithmetic Optimization Algorithm (OBLAOA), and Opposition-Based Chimp Optimization Algorithm (ChOAOBL). The statistical analysis of experimental results using the Wilcoxon Signed Rank Test establishes that the proposed algorithms outperform TSA and other algorithms for most of the problems. Moreover, high dimensions are used to validate the scalability of OCTSA and COCTSA, and the results show that the modified TSA algorithms are least impacted by larger dimensions. The experimental results with statistical analysis demonstrate the effectiveness of the proposed algorithms in solving global optimization problems.

For an extended period, a technological architecture known as cloud IoT links IoT devices to servers located in cloud data centers. Real-time data analytic are made possible by this, enabling better, data-driven decision making, optimization, and risk reduction. Since cloud systems are often located at a considerable distance from IoT devices, the rise of time-sensitive IoT applications has driven the requirement to extend cloud architecture for timely delivery of critical services. Balancing the allocation of IoT services to appropriate edge nodes while guaranteeing low latency and efficient resource utilization remains a challenging task. Since edge nodes have lower resource capabilities than the cloud. The primary drawback of current methods in this situation is that they only tackle the scheduling issue from one side. Task scheduling plays a pivotal role in various domains, including cloud computing, operating systems, and parallel processing, enabling effective management of computational resources. In this research, we provide a multiple-factor autonomous IoT-Edge scheduling method based on game theory to solve this issue. Our strategy involves two distinct scenarios. In the first scenario, we introduced an algorithm containing choices for the IoT and edge nodes, allowing them to evaluate each other using factors such as delay and resource usage. The second scenario involves both a centralized and a distributed scheduling approach, leveraging the matching concept and considering each other. In addition, we also introduced a preference-based stable mechanism (PBSM) algorithm for resource allocation. In terms of the execution time for IoT services and the effectiveness of resource consolidation for edge nodes, the technique we use achieves better results compared with the two commonly used Min-Min and Max-Min scheduling algorithms.

Herbal plants have been used, in light of their responsiveness and wide availability, for the construction of a pioneering nanomaterial. In this study, a colloidal suspension of gold nanoparticles (GNPs) was synthesized from an extract of Madhuca longifolia (ML) using chloroauric acid. For biomedical applications, Madhuca longifolia (ML) was used as a bioreductant as well as a capping agent The formed ML-GNPs were analyzed using different analytical techniques, antioxidant assays, and thiazolyl blue formazan assay against A549 cell lines to evaluate clinical relevance. They were further evaluated for their influence on antimicrobial activity using a disc diffusion test against two different microorganisms, Proteus vulgaris and Micrococcus luteus. The ML-GNPs produced had good antioxidant, antibacterial, and anticancer activities. The conformation of the XRD spectra with prominent characteristic planes was indexed to the face-centered cubic (fcc)-structured GNPs. Surface morphology analysis was used to determine the particle size of the GNPs. Fourier transform infrared spectra of the samples were used to determine the analogs for strong H bonding. The MIC values of biogenic GNPs against both strains of Proteus vulgaris and Micrococcus luteus was calculated as 0.29 and 0.96 g/mL, respectively, and triclosan was considered as 0.4 and 2 g/mL, respectively. The findings of this study will be beneficial for future studies of the therapeutic potential of ML-GNPs. Actively, ML-GNPs can be a capable material for formulating nanomedicines after subsequent clinical experiments.

Abstract Breast cancer is one of the most common cancers in women and the second foremost cause of cancer death in women after lung cancer. Recent technological advances in breast cancer treatment offer hope to millions of women in the world. Segmentation of the breast’s Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) is one of the necessary tasks in the diagnosis and detection of breast cancer. Currently, a popular deep learning model, U-Net is extensively used in biomedical image segmentation. This article aims to advance the state of the art and conduct a more in-depth analysis with a focus on the use of various U-Net models in lesion detection in women’s breast DCE-MRI. In this article, we perform an empirical study of the effectiveness and efficiency of U-Net and its derived deep learning models including ResUNet, Dense UNet, DUNet, Attention U-Net, UNet++, MultiResUNet, RAUNet, Inception U-Net and U-Net GAN for lesion detection in breast DCE-MRI. All the models are applied to the benchmarked 100 Sagittal T2-Weighted fat-suppressed DCE-MRI slices of 20 patients and their performance is compared. Also, a comparative study has been conducted with V-Net, W-Net, and DeepLabV3+. Non-parametric statistical test Wilcoxon Signed Rank Test is used to analyze the significance of the quantitative results. Furthermore, Multi-Criteria Decision Analysis (MCDA) is used to evaluate overall performance focused on accuracy, precision, sensitivity, F $$_1$$ 1 -score, specificity, Geometric-Mean, DSC, and false-positive rate. The RAUNet segmentation model achieved a high accuracy of 99.76%, sensitivity of 85.04%, precision of 90.21%, and Dice Similarity Coefficient (DSC) of 85.04% whereas ResNet achieved 99.62% accuracy, 62.26% sensitivity, 99.56% precision, and 72.86% DSC. ResUNet is found to be the most effective model based on MCDA. On the other hand, U-Net GAN takes the least computational time to perform the segmentation task. Both quantitative and qualitative results demonstrate that the ResNet model performs better than other models in segmenting the images and lesion detection, though computational time in achieving the objectives varies.

Abstract Cancer prediction in the early stage is a topic of major interest in medicine since it allows accurate and efficient actions for successful medical treatments of cancer. Mostly cancer datasets contain various gene expression levels as features with less samples, so firstly there is a need to eliminate similar features to permit faster convergence rate of classification algorithms. These features (genes) enable us to identify cancer disease, choose the best prescription to prevent cancer and discover deviations amid different techniques. To resolve this problem, we proposed a hybrid novel technique CSSMO-based gene selection for cancer classification. First, we made alteration of the fitness of spider monkey optimization (SMO) with cuckoo search algorithm (CSA) algorithm viz., CSSMO for feature selection, which helps to combine the benefit of both metaheuristic algorithms to discover a subset of genes which helps to predict a cancer disease in early stage. Further, to enhance the accuracy of the CSSMO algorithm, we choose a cleaning process, minimum redundancy maximum relevance (mRMR) to lessen the gene expression of cancer datasets. Next, these subsets of genes are classified using deep learning (DL) to identify different groups or classes related to a particular cancer disease. Eight different benchmark microarray gene expression datasets of cancer have been utilized to analyze the performance of the proposed approach with different evaluation matrix such as recall, precision, F1-score, and confusion matrix. The proposed gene selection method with DL achieves much better classification accuracy than other existing DL and machine learning classification models with all large gene expression dataset of cancer.

Abstract Intense sun exposure is a major risk factor for the development of melanoma, an abnormal proliferation of skin cells. Yet, this more prevalent type of skin cancer can also develop in less-exposed areas, such as those that are shaded. Melanoma is the sixth most common type of skin cancer. In recent years, computer-based methods for imaging and analyzing biological systems have made considerable strides. This work investigates the use of advanced machine learning methods, specifically ensemble models with Auto Correlogram Methods, Binary Pyramid Pattern Filter, and Color Layout Filter, to enhance the detection accuracy of Melanoma skin cancer. These results suggest that the Color Layout Filter model of the Attribute Selection Classifier provides the best overall performance. Statistics for ROC, PRC, Kappa, F-Measure, and Matthews Correlation Coefficient were as follows: 90.96% accuracy, 0.91 precision, 0.91 recall, 0.95 ROC, 0.87 PRC, 0.87 Kappa, 0.91 F-Measure, and 0.82 Matthews Correlation Coefficient. In addition, its margins of error are the smallest. The research found that the Attribute Selection Classifier performed well when used in conjunction with the Color Layout Filter to improve image quality.

Parkinson's disease (PD) is an age-related neurodegenerative disorder characterized by motor deficits, including tremor, rigidity, bradykinesia, and postural instability. According to the World Health Organization, about 1 % of the global population has been diagnosed with PD, and this figure is expected to double by 2040. Early and accurate diagnosis of PD is critical to slowing down the progression of the disease and reducing long-term disability. Due to the complexity of the disease, it is difficult to accurately diagnose it using traditional clinical tests. Therefore, it has become necessary to develop intelligent diagnostic models that can accurately detect PD. This article introduces a novel hybrid approach for accurate prediction of PD using an ANFIS with two optimizers, namely Adam and PSO. ANFIS is a type of fuzzy logic system used for nonlinear function approximation and classification, while Adam optimizer has the ability to adaptively adjust the learning rate of each individual parameter in an ANFIS at each training step, which helps the model find a better solution more quickly. PSO is a metaheuristic approach inspired by the behavior of social animals such as birds. Combining these two methods has potential to provide improved accuracy and robustness in PD diagnosis compared to existing methods. The proposed method utilized the advantages of both optimization techniques and applied them on the developed ANFIS model to maximize its prediction accuracy. This system was developed by using an open access clinical and demographic data. The chosen parameters for the ANFIS were selected through a comparative experimental analysis to optimize the model considering the number of fuzzy membership functions, number of epochs of ANFIS, and number of particles of PSO. The performance of the two ANFIS models: ANFIS (Adam) and ANFIS (PSO) focusing at ANFIS parameters and various evaluation metrics are further analyzed in detail and presented, The experimental results showed that the proposed ANFIS (PSO) shows better results in terms of loss and precision, whereas, the ANFIS (Adam) showed the better results in terms of accuracy, f1-score and recall. Thus, this adaptive neural-fuzzy algorithm provides a promising strategy for the diagnosis of PD, and show that the proposed models show their suitability for many other practical applications.

Vehicle emissions are responsible for about 30% of all air pollution in the world. Vehicle emissions can be significantly reduced through the use of selective catalyst reduction (SCR). The present work emphasizes the impact of thermal barrier-coated pistons on diesel engine performance as well as emission qualities. A Ni–Cr–Al–Y bond coat was applied to the tested engine piston that was 50 microns thick and a top coat that was 250 microns thick. These coatings were applied using the plasma spray technique to a combination of 2 mol. % of Gadolinium oxide (Gd2O3), 2 mol. % of Neodymium oxide (Nd2O3), 3 mol. % of Yttria (Y2O3), and continuing 93 mol. % of Zirconia (ZrO2). In a 4-stroke, 1-cylinder diesel engine, the testing was carried out utilizing diesel, Mahua, and Jatropha fuels with and without coating. The selective catalytic reduction technique was employed in the current test to reduce NOx emissions. The findings of this analysis indicate that the brake thermal efficiency of an insulated piston engine improved by 3.9%, and when JB 100 was chosen as the fuel, the insulated piston reduced brake-specific fuel consumption by 3.5% in comparison to the normal piston. In engines coated with SCR, hydrocarbon emissions were lowered by 20.1%, while carbon monoxide emissions were dropped by 13.4%. In comparison to the baseline engine, the oxide of nitrogen emissions were reduced by 39.1%.

This study presents the design and implementation of a Fractional Order Proportional, Integral, and Derivative (FOPID) controller intended for the regulation of blood glucose levels in individuals with type 1 diabetes mellitus (T1DM). The efficacy of this controller is evaluated through its application to a nonlinear Stolwijk–Hardy model simulating T1DM patients, accounting for a range of physiological conditions. Utilizing a genetic algorithm, the parameters of the FOPID controller are fine-tuned. By conducting a comparative analysis with previously established control algorithms, the performance of the proposed controller is validated, demonstrating its superior performance. The results underscore the significant improvements achieved by the proposed controller in maintaining blood glucose concentrations within safe thresholds, particularly in scenarios involving disruptions due to meals.

Deep learning is a very important technique in clinical diagnosis and therapy in the present world. Convolutional Neural Network (CNN) is a recent development in deep learning that is used in computer vision. Our medical investigation focuses on the identification of brain tumour. To improve the brain tumour classification performance a Balanced binary Tree CNN (BT-CNN) which is framed in a binary tree-like structure is proposed. It has a two distinct modules-the convolution and the depthwise separable convolution group. The usage of convolution group achieves lower time and higher memory, while the opposite is true for the depthwise separable convolution group. This balanced binarty tree inspired CNN balances both the groups to achieve maximum performance in terms of time and space. The proposed model along with state-of-the-art models like CNN-KNN and models proposed by Musallam et al., Saikat et al., and Amin et al. are experimented on public datasets. Before we feed the data into model the images are pre-processed using CLAHE, denoising, cropping, and scaling. The pre-processed dataset is partitioned into training and testing datasets as per 5 fold cross validation. The proposed model is trained and compared its perforarmance with state-of-the-art models like CNN-KNN and models proposed by Musallam et al., Saikat et al., and Amin et al. The proposed model reported average training accuracy of 99.61% compared to other models. The proposed model achieved 96.06% test accuracy where as other models achieved 68.86%, 85.8%, 86.88%, and 90.41% respectively. Further, the proposed model obtained lowest standard deviation on training and test accuracies across all folds, making it invariable to dataset.

Diabetes is an enduring metabolic condition identified by heightened blood sugar levels stemming from insufficient production of insulin or ineffective utilization of insulin within the body. India is commonly labeled as the “diabetes capital of the world” owing to the widespread prevalence of this condition. To the best of the authors' last knowledge updated on September 2021, approximately 77 million adults in India were reported to be affected by diabetes, reported by the International Diabetes Federation. Owing to the concealed early symptoms, numerous diabetic patients go undiagnosed, leading to delayed treatment. While Computational Intelligence approaches have been utilized to improve the prediction rate, a significant portion of these methods lacks interpretability, primarily due to their inherent black box nature. Rule extraction is frequently utilized to elucidate the opaque nature inherent in machine learning algorithms. Moreover, to resolve the black box nature, a method for extracting strong rules based on Weighted Bayesian Association Rule Mining is used so that the extracted rules to diagnose any disease such as diabetes can be very transparent and easily analyzed by the clinical experts, enhancing the interpretability. The WBBN model is constructed utilizing the UCI machine learning repository, demonstrating a performance accuracy of 95.8%.

Medical life-saving techniques include mechanical ventilation. During the COVID-19 epidemic, the lack of inexpensive, precise, and accessible mechanical ventilation equipment was the biggest challenge. The global need exploded, especially in developing nations. Global researchers and engineers are developing inexpensive, portable medical ventilators. A simpler mechanical ventilator system with a realistic lungs model is simulated in this work. A systematic ventilation study is done using the dynamic simulation of the model. Simulation findings of various medical disorders are compared to standard data. The maximum lung pressure (Pmax) was 15.78 cmH2O for healthy lungs, 17.72 for cardiogenic pulmonary edema, 16.05 for pneumonia, 19.74 for acute respiratory distress syndrome (ARDS), 17.1 for AECOPD, 19.64 for asthma, and 15.09 for acute intracranial illnesses and head traumas. All were below 30 cmH2O, the average maximum pressure. The computed maximum tidal volume (TDVmax) is 0.5849 l, substantially lower than that of the healthy lungs (0.700 l). The pneumonia measurement was 0.4256 l, substantially lower than the typical 0.798 l. TDVmax was 0.3333 l for ARDS, lower than the usual 0.497 l. The computed TDVmax for AECOPD was 0.6084 l, lower than the normal 0.700 l. Asthma had a TDVmax of 0.4729 l, lower than the typical 0.798 l. In individuals with acute cerebral diseases and head traumas, TDVmax is 0.3511 l, lower than the typical 0.700 l. The results show the viability of the model as it performs accurately to the presented medical condition parameters. Further clinical trials are needed to assess the safety and reliability of the simulation model.

Linum usitatissimum commonly known as flax fibers, emerges as a promising reinforcement phase for artificial polymer resins, boasting ecological benefits, low density, and easy accessibility. However, the mechanical behavior of such composites hinges crucially on factors such as fiber mat thickness, nanoTiO2 filler content, and the application of cryogenic treatment. Addressing this complex interplay, this study employs a hand lay-up technique for composite construction, subjecting nanocomposite plates to the challenging liquid nitrogen conditions at 77 K post-manufacture. Recognizing the need for an optimized approach, Response Surface Methodology (RSM) based on Box-Benhken designs is employed to enhance the mixing features of linum usitatissimum polymer composites. The study calculates anticipated mechanical strength values through rigorous ANOVA inferential analysis, uncovering the pivotal roles played by fiber mat thickness, nanofiller content, and cryogenic treatment in the two feature interactions (2FI) model components. The methodology proves robust with high R2 values (0.9670 for tensile, 0.9845 for flexural, and 0.9670 for interlaminar shear strength) consistently aligning with experimental findings. The study culminates in identifying optimized parameters for maximal mechanical properties—300 gsm flax fiber thickness, 5 wt.% nano TiO2 concentration, and a 15-min cryogenic treatment—a result that advances our understanding of fundamental factors influencing composite performance and provides practical guidelines for applications in fields requiring superior mechanical strength in challenging environments.

Abstract Thyroid cancer is a life-threatening condition that arises from the cells of the thyroid gland located in the neck’s frontal region just below the adam’s apple. While it is not as prevalent as other types of cancer, it ranks prominently among the commonly observed cancers affecting the endocrine system. Machine learning has emerged as a valuable medical diagnostics tool specifically for detecting thyroid abnormalities. Feature selection is of vital importance in the field of machine learning as it serves to decrease the data dimensionality and concentrate on the most pertinent features. This process improves model performance, reduces training time, and enhances interpretability. This study examined binary variants of FOX-optimization algorithms for feature selection. The study employed eight transfer functions (S and V shape) to convert the FOX-optimization algorithms into their binary versions. The vision transformer-based pre-trained models (DeiT and Swin Transformer) are used for feature extraction. The extracted features are transformed using locally linear embedding, and binary FOX-optimization algorithms are applied for feature selection in conjunction with the Naïve Bayes classifier. The study utilized two datasets (ultrasound and histopathological) related to thyroid cancer images. The benchmarking is performed using the half-quadratic theory-based ensemble ranking technique. Two TOPSIS-based methods (H-TOPSIS and A-TOPSIS) are employed for initial model ranking, followed by an ensemble technique for final ranking. The problem is treated as multi-objective optimization task with accuracy, F2-score, AUC-ROC and feature space size as optimization goals. The binary FOX-optimization algorithm based on the $$V_1$$ V 1 transfer function achieved superior performance compared to other variants using both datasets as well as feature extraction techniques. The proposed framework comprised a Swin transformer to extract features, a Fox optimization algorithm with a V1 transfer function for feature selection, and a Naïve Bayes classifier and obtained the best performance for both datasets. The best model achieved an accuracy of 94.75%, an AUC-ROC value of 0.9848, an F2-Score of 0.9365, an inference time of 0.0353 seconds, and selected 5 features for the ultrasound dataset. For the histopathological dataset, the diagnosis model achieved an overall accuracy of 89.71%, an AUC-ROC score of 0.9329, an F2-Score of 0.8760, an inference time of 0.05141 seconds, and selected 12 features. The proposed model achieved results comparable to existing research with small features space.

Abstract An abnormal growth or fatty mass of cells in the brain is called a tumor. They can be either healthy (normal) or become cancerous, depending on the structure of their cells. This can result in increased pressure within the cranium, potentially causing damage to the brain or even death. As a result, diagnostic procedures such as computed tomography, magnetic resonance imaging, and positron emission tomography, as well as blood and urine tests, are used to identify brain tumors. However, these methods can be labor-intensive and sometimes yield inaccurate results. Instead of these time-consuming methods, deep learning models are employed because they are less time-consuming, require less expensive equipment, produce more accurate results, and are easy to set up. In this study, we propose a method based on transfer learning, utilizing the pre-trained VGG-19 model. This approach has been enhanced by applying a customized convolutional neural network framework and combining it with pre-processing methods, including normalization and data augmentation. For training and testing, our proposed model used 80% and 20% of the images from the dataset, respectively. Our proposed method achieved remarkable success, with an accuracy rate of 99.43%, a sensitivity of 98.73%, and a specificity of 97.21%. The dataset, sourced from Kaggle for training purposes, consists of 407 images, including 257 depicting brain tumors and 150 without tumors. These models could be utilized to develop clinically useful solutions for identifying brain tumors in CT images based on these outcomes.

Abstract COVID-19, the global pandemic of twenty-first century, has caused major challenges and setbacks for researchers and medical infrastructure worldwide. The CoVID-19 influences on the patients respiratory system cause flooding of airways in the lungs. Multiple techniques have been proposed since the outbreak each of which is interdepended on features and larger training datasets. It is challenging scenario to consolidate larger datasets for accurate and reliable decision support. This research article proposes a chest X-Ray images classification approach based on feature thresholding in categorizing the CoVID-19 samples. The proposed approach uses the threshold value-based Feature Extraction (TVFx) technique and has been validated on 661-CoVID-19 X-Ray datasets in providing decision support for medical experts. The model has three layers of training datasets to attain a sequential pattern based on various learning features. The aligned feature-set of the proposed technique has successfully categorized CoVID-19 active samples into mild, serious, and extreme categories as per medical standards. The proposed technique has achieved an accuracy of 97.42% in categorizing and classifying given samples sets.

Abstract The cultivation of most crops depends upon the regional weather conditions. So, the analysis of the agro-climatic conditions of a zone contributes significantly to deciding the right crop for the right land in the right season to obtain a better yield. Machine learning algorithms facilitate this process to a great extent for better results. In this paper, the authors proposed an ML-based crop selection model based on the weather conditions and soil parameters, collectively. Weather analysis is done using LSTM RNN and the process of crop selection is completed using Random Forest Classifier. This model gives better results for weather prediction in comparison to ANN. With LSTM RNN, the RMSE observed in Min. Temp. prediction is 5.023%, Max. Temp. Prediction is 7.28%, and Rainfall Prediction is 8.24%. In the second phase, the Random Forest Classifier showed 97.235% accuracy for crop selection, 96.437% accuracy in predicting resource dependency, and 97.647 accuracies in giving the appropriate sowing time for the crop. The model construction time taken with a random forest classifier using mentioned data size is 5.34 s. The authors also suggested the future research direction to further improve this work.

Abstract Breast cancer has emerged as the most life-threatening disease among women around the world. Early detection and treatment of breast cancer are thought to reduce the need for surgery and boost the survival rate. The Magnetic Resonance Imaging (MRI) segmentation techniques for breast cancer diagnosis are investigated in this article. Kapur’s entropy-based multilevel thresholding is used in this study to determine optimal values for breast DCE-MRI lesion segmentation using Gorilla Troops Optimization (GTO). An improved GTO, is developed by incorporating Rotational opposition based-learning (RBL) into GTO called (GTORBL) and applied it to the same problem. The proposed approaches are tested on 20 patients’ T2 Weighted Sagittal (T2 WS) DCE-MRI 100 slices. The proposed approaches are compared with Tunicate Swarm Algorithm (TSA), Particle Swarm Optimization (PSO), Arithmetic Optimization Algorithm (AOA), Slime Mould Algorithm (SMA), Multi-verse Optimization (MVO), Hidden Markov Random Field (HMRF), Improved Markov Random Field (IMRF), and Conventional Markov Random Field (CMRF). The Dice Similarity Coefficient (DSC), sensitivity, and accuracy of the proposed GTO-based approach is achieved $$87.04\%$$ 87.04 % , $$90.96\%$$ 90.96 % , and $$98.13\%$$ 98.13 % respectively. Another proposed GTORBL-based segmentation method achieves accuracy values of $$99.31\%$$ 99.31 % , sensitivity of $$95.45\%$$ 95.45 % , and DSC of $$91.54\%$$ 91.54 % . The one-way ANOVA test followed by Tukey HSD and Wilcoxon Signed Rank Test are used to examine the results. Furthermore, Multi-Criteria Decision Making is used to evaluate overall performance focused on sensitivity, accuracy, false-positive rate, precision, specificity, $$F_1$$ F 1 -score, Geometric-Mean, and DSC. According to both quantitative and qualitative findings, the proposed strategies outperform other compared methodologies.

Software reliability growth models (SRGMs) are universally admitted and employed for reliability assessment. The process of software reliability analysis is separated into two components. The first component is model construction, and the second is parameter estimation. This study concentrates on the second segment parameter estimation. The past few decades of literature observance say that the parameter estimation was typically done by either maximum likelihood estimation (MLE) or least squares estimation (LSE). Increasing attention has been noted in stochastic optimization methods in the previous couple of decades. There are various limitations in the traditional optimization criteria; to overcome these obstacles metaheuristic optimization algorithms are used. Therefore, it requires a method of search space and local optima avoidance. To analyze the applicability of various developed meta-heuristic algorithms in SRGMs parameter estimation. The proposed approach compares the meta-heuristic methods for parameter estimation by various criteria. For parameter estimation, this study uses four meta-heuristics algorithms: Grey-Wolf Optimizer (GWO), Regenerative Genetic Algorithm (RGA), Sine-Cosine Algorithm (SCA), and Gravitational Search Algorithm (GSA). Four popular SRGMs did the comparative analysis of the parameter estimation power of these four algorithms on three actual-failure datasets. The estimated value of parameters through meta-heuristic algorithms are approximately near the LSE method values. The results show that RGA and GWO are better on a variety of real-world failure data, and they have excellent parameter estimation potential. Based on the convergence and R2 distribution criteria, this study suggests that RGA and GWO are more appropriate for the parameter estimation of SRGMs. RGA could locate the optimal solution more correctly and faster than GWO and other optimization techniques.