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Your search keyword '"Schmidt, Kyla M."' showing total 7 results
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7 results on '"Schmidt, Kyla M."'

1. Mn (super)2+ binding to factor VIII subunits and its effect on cofactor activity

Author

Wakabayashi, Hironao, Zhen, Zhu, Schmidt, Kyla M., and Fay, Philip J.

Subjects
Biochemistry -- Research, Manganese -- Physiological aspects, Metal ions -- Physiological aspects, Calcium compounds -- Physiological aspects, Proteins -- Physiological aspects, Biological sciences, Chemistry
Abstract

Research has been conducted on metal ions Ca (super)2+ and Mn (super)2+ which are important for cofactor activity generation following factor VIII reconstitution from its isolated light and heavy chains. Results demonstrate that similar to Ca (super)2+, Mn (super)2+ has a high-affinity binding site for factor VIII which does not affect the affinity of heavy or light chains of factor VIII heterodimer.

Published
2003

2. Ca (super)2+ binding to both the heavy and light chains of factor VIII is required for cofactor activity

Author

Wakabayashi, Hironao, Schmidt, Kyla M., and Fay, Philip J.

Subjects
Biochemistry -- Research, Calcium -- Physiological aspects, Carrier proteins -- Physiological aspects, Chemical reactions -- Analysis, Biological sciences, Chemistry
Abstract

Research has been conducted on the factor VIII interactions with Ca (super)2+. Results indicate the existence of Ca (super)2+ binding sites in factor VIII and that Ca (super)2+ must be bound to either heavy or light chain to generate active factor VIII.

Published
2002

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