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1. Transcriptomic and cellular decoding of functional brain connectivity changes reveal regional brain vulnerability to pro- and anti-inflammatory therapies

Author: Martins, D., Dipasquale, O., Davies, K., Cooper, E., Tibble, J., Veronese, M., Frigo, M., Williams, S.C.R., Turkheimer, F., Cercignani, M., Harrison, N.A., King‘s College London, University of Sussex, Brighton and Sussex University Hospitals - NHS Trust (BSUH), Department of Information Engineering [Padova] (DEI), Università degli Studi di Padova = University of Padua (Unipd), Computational Imaging of the Central Nervous System (ATHENA), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Cardiff University's Brain Research Imaging Centre [Cardiff] (CUBRIC), School of Psychology [Cardiff University], Cardiff University-Cardiff University, Cardiff University, DM, OD, MV, FET and SCRM are supported by the NIHR Maudsley’s Biomedical Research Centre at the South London and Maudsley NHS Trust. MF is funded by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (ERC Advanced Grant agreement No 694665: CoBCoM - Computational Brain Connectivity Mapping)., and European Project: 694665,H2020 ERC,ERC-2015-AdG,CoBCoM(2016)
Subjects: Inflammation, Depression, Endocrine and Autonomic Systems, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Immunology, Anti-Inflammatory Agents, Brain, Interferon-alpha, [SDV.IMM.IMM]Life Sciences [q-bio]/Immunology/Immunotherapy, Transcriptomic vulnerability, global brain connectivity, Anti-TNF, Behavioral Neuroscience, [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, Humans, Tumor Necrosis Factor Inhibitors, Imaging transcriptomics, Transcriptome, Interferon-α
Abstract: Background\ud Systemic inflammation induces acute changes in mood, motivation and cognition that closely resemble those observed in depressed individuals. However, the mechanistic pathways linking peripheral inflammation to depression-like psychopathology via intermediate effects on brain function remain incompletely understood.\ud \ud Methods\ud We combined data from 30 patients initiating interferon-α treatment for Hepatitis-C and 20 anti-tumour necrosis factor (TNF) therapy for inflammatory arthritis and used resting-state functional magnetic resonance imaging to investigate acute effects of each treatment on regional global brain connectivity (GBC). We leveraged transcriptomic data from the Allen Human Brain Atlas to uncover potential biological and cellular pathways underpinning regional vulnerability to GBC changes induced by each treatment.\ud \ud Results\ud Interferon-α and anti-TNF therapies both produced differential small-to-medium sized decreases in regional GBC. However, these were observed within distinct brain regions and the regional patterns of GBC changes induced by each treatment did not correlate suggesting independent underlying processes. Further, the spatial distribution of these differential GBC decreases could be captured by multivariate patterns of constitutive regional expression of genes respectively related to: i) neuroinflammation and glial cells; and ii) glutamatergic neurotransmission and neurons. The extent to which each participant expressed patterns of GBC changes aligning with these patterns of transcriptomic vulnerability also correlated with both acute treatment-induced changes in interleukin-6 (IL-6) and, for Interferon-α, longer-term treatment-associated changes in depressive symptoms.\ud \ud Conclusions\ud Together, we present two transcriptomic models separately linking regional vulnerability to the acute effects of interferon-α and anti-TNF treatments on brain function to glial neuroinflammation and glutamatergic neurotransmission. These findings generate hypotheses about two potential brain mechanisms through which bidirectional changes in peripheral inflammation may contribute to the development/resolution of psychopathology.
Published: 2022

2. Sec22b is a critical and non-redundant regulator of plasma cell maintenance

Author: Amélie Bonaud, Laetitia Gargowitsch, Simon M. Gilbert, Elanchezhian Rajan, Pablo Canales-Herrerias, Daniel Stockholm, Nabila F. Rahman, Mark O. Collins, Hakan Taskiran, Danika L. Hill, Andres Alloatti, Nagham Alouche, Stéphanie Balor, Vanessa Soldan, Daniel Gillet, Julien Barbier, Françoise Bachelerie, Kenneth G. C. Smith, Julia Jellusova, Pierre Bruhns, Sebastian Amigorena, Karl Balabanian, Michelle A. Linterman, Andrew A. Peden, Marion Espéli, Institut de Recherche Saint-Louis - Hématologie Immunologie Oncologie (Département de recherche de l’UFR de médecine, ex- Institut Universitaire Hématologie-IUH) (IRSL), Université Paris Cité (UPCité), Microenvironnement des niches tumorales (CNRS GDR 3697 Micronit ), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Inflammation, microbiome, immunosurveillance (MI2), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, University of Cambridge [UK] (CAM), University of Sheffield [Sheffield], Anticorps en thérapie et pathologie - Antibodies in Therapy and Pathology, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL), Centre de Recherche Saint-Antoine (CRSA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), School of Psychology [Cardiff University], Cardiff University, Technische Universität München = Technical University of Munich (TUM), Max Planck Institute of Immunobiology and Epigenetics (MPI-IE), Max-Planck-Gesellschaft, The Babraham Institute [Cambridge, UK], Monash University [Melbourne], Immunité et cancer (U932), Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Universidad Nacional de Rosario [Santa Fe], Centre de Biologie Intégrative (CBI), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Service d'Ingénierie Moléculaire pour la Santé (ex SIMOPRO) (SIMoS), Médicaments et Technologies pour la Santé (MTS), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), ANR-19-CE15-0019,PC-SEC,Impact des SNARE sur la biologie des plasmocytes(2019), ANR-14-ACHN-0008,AUTO-PLASMO,Analyse integrative de la biologie des plasmocytes normaux et pathologiques(2014), ANR-17-CE14-0019,OSTEOVALYMPH,Autocrinie et paracrinie de l'axe de signalisation CXCL12/CXCR4-CXCR7 dans la niche ostéo-vasculaire: impact sur la spécification et l'engagement lymphoïde des cellules souches hématopoïétiques(2017), ANR-18-CE15-0001,Autoimmuni-B,Etude de la rupture de tolérance dans une maladie humaine autoimmune médiée par les lymphocytes B(2018), The study was supported by the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LabEx LERMIT) (M.E. and K.B.), an ANR JCJC grant (ANR-19-CE15-0019-01), an ANR @RAction grant (ANR-14-ACHN-0008), a 'Fondation ARC pour la recherche sur le cancer' grant (P JA20181208173), and a grant from IdEx Université Paris-Cité (ANR-18-IDEX-0001) to M.E., and an ANR PRC grant (ANR-17-CE14-0019) and an INCa grant (PRT-K 2017) to K.B. P.B. acknowledges funding from the French National Research Agency grant ANR-18-CE15-0001 project Autoimmuni-B, by the Institut Carnot Pasteur Microbes et Santé grant ANR-11-CARN-0017-01, the Institut Pasteur, and the Institut National de la Santé et de la Recherche Médicale (INSERM). M.A.L. is supported by Biotechnology and Biological Sciences Research Council (BBS/E/B/000C0427, BBS/E/B/000C0428, and the Campus Capability Core Grant to the Babraham Institute). A.A.P. and M.O.C. were supported by a grant from the Biotechnology and Biological Sciences Research Council (BB/L022389/1). D.L.H. is supported by a National Health and Medical Research Council Australia Early-Career Fellowship (APP1139911). N.A. was supported by a PhD fellowship from the French Ministry for education and by a fourth year PhD fellowship from the 'Fondation ARC pour la recherche sur le cancer.' P.C.-H. was supported partly by a stipend from the Pasteur-Paris University (PPU) International PhD program, and by a fellowship from the French Fondation pour la Recherche Médicale (FRM). K.G.C.S. was supported by the Wellcome Trust (Programme Grant Number 083650/Z/07/Z). J.J’s research is supported by the German Research Foundation project number: 419193696 and through the CRC1335. H.T. is supported through the graduate school of the Max Planck Institute for Immunobiology and Epigenetics (IMPRS-IE) and through the CRC1335. The 'EMiLy' U1160 INSERM unit is a member of the OPALE Carnot institute, The Organization for Partnerships in Leukemia (Institut Carnot OPALE, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Web: www.opale.org. Email: contact@opale.org)., ANR-18-IDEX-0001,Université de Paris,Université de Paris(2018), Bonaud, Amélie [0000-0002-4153-9171], Rajan, Elanchezhian [0000-0002-6257-3678], Canales-Herrerias, Pablo [0000-0002-1865-6476], Stockholm, Daniel [0000-0002-5069-5256], Collins, Mark O [0000-0002-7656-4975], Taskiran, Hakan [0000-0002-2690-3887], Alloatti, Andres [0000-0003-0555-0653], Gillet, Daniel [0000-0003-0477-3599], Bruhns, Pierre [0000-0002-4709-8936], Balabanian, Karl [0000-0002-0534-3198], Linterman, Michelle A [0000-0001-6047-1996], Peden, Andrew A [0000-0003-0144-7712], Espéli, Marion [0000-0001-5005-1664], and Apollo - University of Cambridge Repository
Subjects: R-SNARE Proteins, mitochondria, Mice, endoplasmic reticulum, Multidisciplinary, plasma cell, SNARE, antibody, [SDV]Life Sciences [q-bio], Plasma Cells, Animals, Biological Transport, SNARE Proteins
Abstract: Despite the essential role of plasma cells in health and disease, the cellular mechanisms controlling their survival and secretory capacity are still poorly understood. Here, we identified the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) Sec22b as a unique and critical regulator of plasma cell maintenance and function. In the absence of Sec22b, plasma cells were hardly detectable and serum antibody titers were dramatically reduced. Accordingly, Sec22b -deficient mice fail to mount a protective immune response. At the mechanistic level, we demonstrated that Sec22b contributes to efficient antibody secretion and is a central regulator of plasma cell maintenance through the regulation of their transcriptional identity and of the morphology of the endoplasmic reticulum and mitochondria. Altogether, our results unveil an essential and nonredundant role for Sec22b as a regulator of plasma cell fitness and of the humoral immune response.
Published: 2023

3. Further Evidence That People Rely on Egocentric Information to Guide a Cursor to a Visible Target

Author: Simon Rushton, Martin Bossard, Katja Fiehler, Emily M. Crowe, Harun Karimpur, Eli Brenner, School of Psychology [Cardiff University], Cardiff University, Sensorimotor Control, AMS - Sports, and IBBA
Subjects: Computer science, perturbation, Movement, Experimental and Cognitive Psychology, allocentric, Frame of reference, Cursor (databases), 050105 experimental psychology, 03 medical and health sciences, [SCCO]Cognitive science, 0302 clinical medicine, Artificial Intelligence, Humans, 0501 psychology and cognitive sciences, Computer vision, pointing/hitting, business.industry, perception/action, 05 social sciences, frames of reference, SDG 10 - Reduced Inequalities, Hand, Object (philosophy), Sensory Systems, Short and Sweet, Ophthalmology, Space Perception, Mental Recall, [SCCO.PSYC]Cognitive science/Psychology, Artificial intelligence, business, 030217 neurology & neurosurgery
Abstract: International audience; Everyday movements are guided by objects’ positions relative to other items in the scene (allocentric information) as well as by objects’ positions relative to oneself (egocentric information). Allocentric information can guide movements to the remembered positions of hidden objects, but is it also used when the object remains visible? To stimulate the use of allocentric information, the position of the participant’s finger controlled the velocity of a cursor that they used to intercept moving targets, so there was no one-to-one mapping between egocentric positions of the hand and cursor. We evaluated whether participants relied on allocentric information by shifting all task-relevant items simultaneously leaving their allocentric relationships unchanged. If participants rely on allocentric information they should not respond to this perturbation. However, they did. They responded in accordance with their responses to each item shifting independently, supporting the idea that fast guidance of ongoing movements primarily relies on egocentric information.
Published: 2021

4. Why lockdown and distance learning during the COVID-19 pandemic are likely to increase the social class achievement gap

Author: Sébastien Goudeau, Camille Sanrey, Arnaud Stanczak, Antony Stephen Reid Manstead, Céline Darnon, Centre de Recherches sur la Cognition et l'Apprentissage (CeRCA), Université de Poitiers-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Psychologie Sociale et Cognitive (LAPSCO), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), School of Psychology [Cardiff University], Cardiff University, ANR-19-CE28-0007,PRESCHOOL,Pourquoi l'école maternelle ne réduit pas les inégalités scolaires initiales liées à l'origine sociale ? Examen du rôle des interactions langagières en classe et évaluation d'une intervention à destination des enseignants.(2019), and Centre National de la Recherche Scientifique (CNRS)-Université de Tours-Université de Poitiers
Subjects: Social Psychology, Inequality, [SHS.EDU]Humanities and Social Sciences/Education, media_common.quotation_subject, Distance education, [SHS.PSY]Humanities and Social Sciences/Psychology, CHILDREN, Experimental and Cognitive Psychology, Context (language use), Social class, DIGITAL DIVIDE, 050105 experimental psychology, Education, Distance, MATHEMATICS, Behavioral Neuroscience, Multidisciplinary approach, PARENTAL INVOLVEMENT, ComputingMilieux_COMPUTERSANDEDUCATION, Humans, SOCIOECONOMIC-STATUS, 0501 psychology and cognitive sciences, Sociology, HOME, 10. No inequality, Set (psychology), media_common, Family Characteristics, INCOME, SARS-CoV-2, business.industry, 4. Education, 05 social sciences, COVID-19, 050301 education, SELF-EFFICACY, Public relations, Social Class, Socioeconomic Factors, Work (electrical), Communicable Disease Control, Needs assessment, SUMMER SCHOOL, INTERNET USE, business, 0503 education, Needs Assessment
Abstract: International audience; The COVID-19 pandemic has forced teachers and parents to quickly adapt to a new educational context: distance learning. Teachers developed online academic material while parents taught the exercises and lessons provided by teachers to their children at home. Considering that the use of digital tools in education has dramatically increased during this crisis, and it is set to continue, there is a pressing need to understand the impact of distance learning. Taking a multidisciplinary view, we argue that by making the learning process rely more than ever on families, rather than on teachers, and by getting students to work predominantly via digital resources, school closures exacerbate social class academic disparities. To address this burning issue, we propose an agenda for future research and outline recommendations to help parents, teachers and policymakers to limit the impact of the lockdown on social-class-based academic inequality.
Published: 2021

5. Spatial and temporal integration of 2-probe stimuli

Author: Martin, Nicholas, Rushton, Simon, Bossard, Martin, School of Psychology [Cardiff University], Cardiff University, Institut des Sciences du Mouvement Etienne Jules Marey (ISM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), and Supported by ESRC research grant, ES/S015272/1 awarded to Simon K. Rushton.
Subjects: [SCCO.NEUR]Cognitive science/Neuroscience, [SHS.PSY]Humanities and Social Sciences/Psychology
Abstract: International audience; Integration of signals across space and time by the visual system is well studied in behavioural studies and, within specific limits, is described by Ricco's area and Bloch's law respectively. What is unclear is whether the area of integration changes as a function of time. There are two reasons to hypothesize that it might. First, even during fixation, the eyes continually move. The brain could compensate for small eye movement by increasing the size of the area of integration across time. Second, the receptive fields of some individual neurons shift over time. When neurons are combined in populations, the area of integration might be expected to resemble concentric travelling waves. In our experiment, stimuli consisted of two probes presented with varying spatial (0 to .9dva) and temporal (0 to 100ms) separation, randomly appearing at one of four known-locations. A 4-AFC target detection task was used to identify the luminance thresholds where probes of varying spatial and temporal properties were detected with 75% accuracy. As spatial separation increased, the temporal separation at which the probes are most easily detected also increased. That is, probes with moderate spatial separation are more easily detected when they also have temporal separation than when the two probes are presented simultaneously. These findings indicate an interaction between space and time during integration of signals. The pattern of results is compatible with drifting receptive fields.
Published: 2022

6. On the generalizability of diffusion MRI signal representations across acquisition parameters, sequences and tissue types: chronicles of the MEMENTO challenge

Author: Daniel C. Alexander, Andrada Ianus, Zhijie Zhang, Mingwu Jin, Geert Jan Biessels, Mauro Zucchelli, Santiago Aja-Fernández, Ariel Rokem, Vesna Prchkovska, Rachid Deriche, Alexander Leemans, Matteo Frigo, Vishwesh Nath, Eleftherios Garyfallidis, Rutger Fick, Derek K. Jones, Evren Özarslan, Maryam Afzali, Marco Palombo, Martijn Froeling, Haoze Chen, Jan Sijbers, Abib Alimi, Prasanna Parvathaneni, Paulo Rodrigues, Sara Sedlar, Tomasz Pieciak, Stefan Endres, Markus Nilsson, Fabian Bogusz, Bennett A. Landman, Shreyas Fadnavis, Enes Albay, Noam Shemesh, Jan Morez, Irina Sánchez, Ben Jeurissen, Fengxiang Wang, Alberto De Luca, Samuel Deslauriers-Gauthier, Kurt G. Schilling, Hui Zhang, Image sciences institute - University of Utrecht (ISI), University Medical Center [Utrecht], Utrecht Brain Center [UMC], Champalimaud Centre for the Unknown [Lisbon], Laboratoire des Maladies Neurodégénératives - UMR 9199 (LMN), Service MIRCEN (MIRCEN), Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie François JACOB (JACOB), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie François JACOB (JACOB), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), Centre for Medical Image Computing (CMIC), University College of London [London] (UCL), Department of Forest Ecology and Management, Swedish University of Agricultural Sciences (SLU), Computational Imaging of the Central Nervous System (ATHENA), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Istanbul Technical University (ITÜ), TRIBVN Healthcare, Cardiff University's Brain Research Imaging Centre [Cardiff] (CUBRIC), School of Psychology [Cardiff University], Cardiff University-Cardiff University, Department of Automatics (AGH-UST), AGH University of Science and Technology [Krakow, PL] (AGH UST), Laboratorio de Procesado de Imagen [Valladolid] (LPI), Université de Valladolid, Department of Biomedical Engineering [Linköping], Linköping University (LIU), Taiyuan University of Technology, University of Texas at Arlington [Arlington], NVIDIA (NVIDIA), National Institutes of Health [Bethesda] (NIH), Vision Lab [Antwerp], University of Antwerp (UA), Indiana University [Bloomington], Indiana University System, Institute of Materials Engineering [Bremen] (IWT ), University of Bremen, University of Washington [Seattle], QMENTA Inc, Vanderbilt University [Nashville], Vanderbilt University Medical Center [Nashville], ANR-19-P3IA-0002,3IA@cote d'azur,3IA Côte d'Azur(2019), European Project: 694665,H2020 ERC,ERC-2015-AdG,CoBCoM(2016), UMC Utrecht, Centre National de la Recherche Scientifique (CNRS)-Service MIRCEN (MIRCEN), Université Paris-Saclay-Institut de Biologie François JACOB (JACOB), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Institut de Biologie François JACOB (JACOB), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Department of Physics, The University of Texas at Arlington, United States, and Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville
Subjects: Mean squared error, Databases, Factual, Computer science, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, Cognitive Neuroscience, Neurosciences. Biological psychiatry. Neuropsychiatry, computer.software_genre, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, Mice, 0302 clinical medicine, Bayesian information criterion, Voxel, Encoding (memory), Image Processing, Computer-Assisted, Animals, Humans, Generalizability theory, Computer. Automation, Hyperparameter, Bioinformatics (Computational Biology), business.industry, Physics, Brain, Pattern recognition, Data point, Diffusion Magnetic Resonance Imaging, Neurology, Bioinformatik (beräkningsbiologi), Human medicine, Artificial intelligence, Neural Networks, Computer, business, computer, 030217 neurology & neurosurgery, RC321-571, Diffusion MRI
Abstract: Diffusion MRI (dMRI) has become an invaluable tool to assess the microstructural organization of brain tissue. Depending on the specific acquisition settings, the dMRI signal encodes specific properties of the underlying diffusion process. In the last two decades, several signal representations have been proposed to fit the dMRI signal and decode such properties. Most methods, however, are tested and developed on a limited amount of data, and their applicability to other acquisition schemes remains unknown. With this work, we aimed to shed light on the generalizability of existing dMRI signal representations to different diffusion encoding parameters and brain tissue types. To this end, we organized a community challenge - named MEMENTO, making available the same datasets for fair comparisons across algorithms and techniques. We considered two state-of-the-art diffusion datasets, including single-diffusion-encoding (SDE) spin-echo data from a human brain with over 3820 unique diffusion weightings (the MASSIVE dataset), and double (oscillating) diffusion encoding data (DDE/DODE) of a mouse brain including over 2520 unique data points. A subset of the data sampled in 5 different voxels was openly distributed, and the challenge participants were asked to predict the remaining part of the data. After one year, eight participant teams submitted a total of 80 signal fits. For each submission, we evaluated the mean squared error, the variance of the prediction error and the Bayesian information criteria. The received submissions predicted either multi-shell SDE data (37%) or DODE data (22%), followed by cartesian SDE data (19%) and DDE (18%). Most submissions predicted the signals measured with SDE remarkably well, with the exception of low and very strong diffusion weightings. The prediction of DDE and DODE data seemed more challenging, likely because none of the submissions explicitly accounted for diffusion time and frequency. Next to the choice of the model, decisions on fit procedure and hyperparameters play a major role in the prediction performance, highlighting the importance of optimizing and reporting such choices. This work is a community effort to highlight strength and limitations of the field at representing dMRI acquired with trending encoding schemes, gaining insights into how different models generalize to different tissue types and fiber configurations over a large range of diffusion encodings. Funding Agencies|European Research Council (ERC) under the European UnionEuropean Research Council (ERC) [694665]; French government, through the 3IA Cote DAzur Investments in the Future project [ANR-19-P3IA-0002]; EPSRCUK Research & Innovation (UKRI)Engineering & Physical Sciences Research Council (EPSRC) [EP/N018702/1, MR/T020296/1, ISLRA-2009]; European Space AgencyEuropean Space AgencyEuropean Commission; Belgian Science Policy Office-ProdexBelgian Federal Science Policy Office; Research Foundation Flanders (FWO Vlaanderen)FWO [12M3119N, G0D7216N]; Wellcome Trust Investigator AwardWellcome Trust [096646/Z/11/Z]; Wellcome Trust Strategic AwardWellcome Trust [104943/Z/14/Z]; Polish National Agency for Academic ExchangePolish National Agency for Academic Exchange (NAWA) [PN/BEK/2019/1/00421]; Ministry of Science and Higher Education (Poland)Ministry of Science and Higher Education, Poland [692/STYP/13/2018]; AGH Science and Technology, Poland [16.16.120.773]; Linkoping University (LiU) Center for Industrial Information Technology (CENIIT); LiU Cancer [VINNOVA/ITEA3 17021 IMPACT]; Swedish Foundation for Strategic ResearchSwedish Foundation for Strategic Research [RMX18-0056]; "la Caixa" FoundationLa Caixa Foundation [100010434]; European UnionEuropean Commission [847648, LCF/BQ/PI20/11760029]; Ministerio de Ciencia e Innovacion" of SpainSpanish Government [RTI2018-094569-B-I00]; National Institute for Biomedical Imaging [5R01EB027585-02]
Published: 2021

7. The R1-weighted connectome: complementing brain networks with a myelin-sensitive measure

Author: Ljupco Kocarev, Nikola Stikov, Julien Cohen-Adad, Matteo Mancini, Bratislav Misic, Tommy Boshkovski, Stéphane Lehéricy, Macedonian Academy of Sciences and Arts [Skopje, North Macedonia] (MASA), Université de Montréal (UdeM), Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal (CRIUGM), Montreal Neurological Institute and Hospital, McGill University = Université McGill [Montréal, Canada], Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre de Neuro-Imagerie de Recherche (CENIR), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Montreal Heart Institute - Institut de Cardiologie de Montréal, University of Sussex, Cardiff University's Brain Research Imaging Centre [Cardiff] (CUBRIC), School of Psychology [Cardiff University], Cardiff University-Cardiff University, Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Center for NeuroImaging Research-Human MRI Neuroimaging core facility for clinical research [ICM Paris] (CENIR), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], and Gestionnaire, Hal Sorbonne Université
Subjects: Computer science, [SDV]Life Sciences [q-bio], Early detection, Neurosciences. Biological psychiatry. Neuropsychiatry, Longitudinal Relaxation Rate, Biology, Measure (mathematics), Diffusion MRI, 030218 nuclear medicine & medical imaging, White matter, 03 medical and health sciences, Myelin, 0302 clinical medicine, Artificial Intelligence, Connectome, medicine, 10. No inequality, Brain function, 030304 developmental biology, 0303 health sciences, Applied Mathematics, General Neuroscience, Quantitative MRI, Structural connectome, Computer Science Applications, [SDV] Life Sciences [q-bio], medicine.anatomical_structure, Neuroscience, 030217 neurology & neurosurgery, Research Article, Tractography, RC321-571
Abstract: Myelin plays a crucial role in how well information travels between brain regions. Complementing the structural connectome, obtained with diffusion MRI tractography, with a myelin-sensitive measure could result in a more complete model of structural brain connectivity and give better insight into white-matter myeloarchitecture. In this work we weight the connectome by the longitudinal relaxation rate (R1), a measure sensitive to myelin, and then we assess its added value by comparing it with connectomes weighted by the number of streamlines (NOS). Our analysis reveals differences between the two connectomes both in the distribution of their weights and the modular organization. Additionally, the rank-based analysis shows that R1 can be used to separate transmodal regions (responsible for higher-order functions) from unimodal regions (responsible for low-order functions). Overall, the R1-weighted connectome provides a different perspective on structural connectivity taking into account white matter myeloarchitecture., Author Summary In the present work, we show that by using a myelin-sensitive measure we can complement the diffusion MRI-based connectivity and provide a different picture of the brain organization. We show that the R1-weighted average distribution does not follow the same trend as the number of streamlines strength distribution, and the two connectomes exhibit different modular organization. We also show that unimodal cortical regions tend to be connected by more streamlines, but the connections exhibit a lower R1-weighted average, while the transmodal regions have higher R1-weighted average but fewer streamlines. This could imply that the unimodal regions require more connections with lower myelination, whereas the transmodal regions rely on connections with higher myelination.
Published: 2021

8. SANDI-AMICO: an open-source toolbox for fast Soma And Neurite Density Imaging (SANDI) with AMICO

Author: Schiavi, Simona, Ocampo-Pineda, Mario, Truffet, Raphaël, Caruyer, Emmanuel, Daducci, Alessandro, Palombo, Marco, Department of Computer Science [Verona] (UNIVR | DI), Università degli studi di Verona = University of Verona (UNIVR), Università degli studi di Genova = University of Genoa (UniGe), Vision, Action et Gestion d'informations en Santé (VisAGeS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Inria Rennes – Bretagne Atlantique, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-SIGNAUX ET IMAGES NUMÉRIQUES, ROBOTIQUE (IRISA-D5), Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Neuroimagerie: méthodes et applications (EMPENN), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-SIGNAL, IMAGE ET LANGAGE (IRISA-D6), University College of London [London] (UCL), Cardiff University's Brain Research Imaging Centre [Cardiff] (CUBRIC), School of Psychology [Cardiff University], Cardiff University-Cardiff University, Cardiff University, and Caruyer, Emmanuel
Subjects: [SCCO.COMP] Cognitive science/Computer science, [SCCO.COMP]Cognitive science/Computer science
Abstract: International audience; The soma and neurite density imaging (SANDI) model has been recently introduced to estimate diffusion MRI indices of apparent neurite and soma density noninvasively in the brain. Here, we introduce SANDIAMICO a fast (10 seconds for whole brain images) and robust implementation for estimating SANDI parameters using the Accelerated Microstructure Imaging via Convex Optimization (AMICO) framework. Using numerical simulations and in vivo human data, we show excellent performances of SANDIAMICO in terms of accuracy, precision, robustness to noise and intra-subject reproducibility.
Published: 2021

9. Equalization-cancellation revisited

Author: Culling, John, School of Psychology [Cardiff University], and Cardiff University
Subjects: [PHYS.MECA.VIBR]Physics [physics]/Mechanics [physics]/Vibrations [physics.class-ph], model, masking, binaural, [PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph]
Abstract: International audience; Binaural masking level differences (BMLDs) are improvements in the masked detection thresholds of sounds that require binaural listening and are not attributable to improvements in signal-to-noise ratio. A BMLD can occur when there are differences in interaural phase, delay or level between target and masker. Equalization cancellation (EC) theory has long been a popular framework for explaining BMLDs. Durlach (1963, 1972) developed EC theory mathematically, predicting the results of each experiment using specific equations. His EC theory is admirably simple in concept and has only two fitted parameters, yet it generates many accurate predictions and invariably captures the general pattern of the data. However, some predictions remain grossly inaccurate or ambiguous. Two adapted EC models will be presented. One is a hybrid model that derives internal representations of the speech and noise computationally and then uses a single equation to predict the BMLD. The other is completely computational. The models include broadened auditory filtering, a cost function for the use of large internal delays, and, in the case for the computational model, peripheral non-linearities. The models will be used to demonstrate that a cost function and peripheral non-linearities are essential to provide accurate predictions of classic results in the literature. Broadened auditory filters have some explanatory power, but their role is indistinguishable with broadened from that of delay cost.
Published: 2020

10. ?Turn an ear to hear?: the benefit of head orientation to speech intelligibility in complex acoustic environments

Author: Grange, Jacques, Culling, John, Espaces, Nature et Culture (ENeC), Université Paris-Sorbonne (UP4)-Centre National de la Recherche Scientifique (CNRS), School of Psychology [Cardiff University], and Cardiff University
Subjects: [PHYS.MECA.VIBR]Physics [physics]/Mechanics [physics]/Vibrations [physics.class-ph], cochlear implant, BF, RF, hearing impairment, head-shadow benefit, head-orientation benefit, [PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph]
Abstract: International audience; Spatial release from masking is the speech-reception threshold improvement from the spatial separation of target speech and interferer(s). It has traditionally been studied with listeners facing the target talker, because such attitude had long been assumed to be most natural or required, either for optimal lip-reading performance or to benefit from the directionality of prostheses microphones. In the laboratory, with a single interferer in the rear hemifield, Grange & Culling (JASA 2016a,b) and Grange et al. (Trends in Hearing 2018) showed that a modest, 30ᴼ head orientation away from directly facing the target benefited normal-hearing listeners and cochlear implant users alike by as much as 4.5 dB. The lip-reading benefit was also unaffected by head orientation, such that both benefits are cumulative. Furthermore, because a directional-microphone sensitivity pattern is rotated 30-45ᴼ by the acoustic head-shadow, the head- orientation benefit (HOB) persisted with microphone directionality. Of special interest here is confirming the robustness of HOB in complex acoustic environments. To do so, an advanced simulation of a real restaurant was developed. Acquisition of binaural room impulse responses measured with a head and torso simulator moved across the restaurant enabled the simulation over headphones of a listener sat at one of 6 tables, attending to a talker sat across that table and either facing the talker or with a 30ᴼ head turn either side. Nine interferers were distributed across the restaurant. These could be either continuous target- speech-shaped noise or interfering voices. Studies employing normal-hearing listeners, mildly-moderately impaired listeners or simulated cochlear implant users revealed a 1-2 dB HOB at the best predicted 30ᴼ head orientation for all listeners, regardless of table position in the restaurant. This confirmed the robustness of HOB, even with the diffuse interference generated by the combination of spatially distributed interferers and reverberation typically found in social settings.
Published: 2020

11. How to optimise your speech intelligibility in a noisy restaurant

Author: Culling, John, Grange, Jacques, Bardsley, Barry, Ainge, Eleanor, School of Psychology [Cardiff University], Cardiff University, Espaces, Nature et Culture (ENeC), and Université Paris-Sorbonne (UP4)-Centre National de la Recherche Scientifique (CNRS)
Subjects: [PHYS.MECA.VIBR]Physics [physics]/Mechanics [physics]/Vibrations [physics.class-ph], head orientation, seating position, reverberation, speech intelligibility, [PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph]
Abstract: International audience; A model of spatial release from masking in reverberant environments has proved successful in predicting a wide range of empirical data, particularly for noise interferers or where there are multiple interfering voices. Here, we show how the model can be used to successfully predict optimal behaviour in such environments. Head orientation of around 30° away from the target speaker was predicted, and then shown empirically to improve speech intelligibility for normally hearing listeners, hearing-impaired listeners and cochlear implant users. This degree of head orientation was also shown to be compatible with lip-reading and robust to reverberation. However, location within a room, even one uniformly distributed with interfering sound sources, was predicted to have a strong influence on the effective signal-to-noise ratio and on the benefits of head orientation and directional microphones. Certain locations were predicted to bring all these benefits together and others to largely confound them. These differences were confirmed empirically for the benefits of signal-to-noise ratio and head orientation using virtual acoustics.
Published: 2020

12. Clarity: Machine Learning Challenges to Revolutionise Hearing Device Processing

Author: Graetzer, SN, Akeroyd, M, Barker, J, Cox, TJ, Culling, J, Naylor, G, Porter, E, Viveros Munoz, R, Department of Computer Science [Sheffield], University of Sheffield [Sheffield], School of Psychology [Cardiff University], Cardiff University, Grasslands Research Centre, and AgResearch Ltd
Subjects: [PHYS.MECA.VIBR]Physics [physics]/Mechanics [physics]/Vibrations [physics.class-ph], machine learning, Audio and Speech Processing (eess.AS), hearing, speech, FOS: Electrical engineering, electronic engineering, information engineering, competition, Electrical Engineering and Systems Science - Audio and Speech Processing, [PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph]
Abstract: In the Clarity project, we will run a series of machine learning challenges to revolutionise speech processing for hearing devices. Over five years, there will be three paired challenges. Each pair will consist of a competition focussed on hearing-device processing ("enhancement") and another focussed on speech perception modelling ("prediction"). The enhancement challenges will deliver new and improved approaches for hearing device signal processing for speech. The parallel prediction challenges will develop and improve methods for predicting speech intelligibility and quality for hearing impaired listeners. This Engineering and Physical Sciences Research Council (EPSRC) funded project involves researchers from the Universities of Sheffield, Salford, Nottingham and Cardiff in conjunction with the Hearing Industry Research Consortium, Action on Hearing Loss, Amazon, and Honda. To register interest in the challenges, go to www.claritychallenge.org., Comment: 3 pages, 2 figures
Published: 2020

13. 5′ splice site GC>GT and GT>GC variants differ markedly in terms of their functionality and pathogenicity

Author: Zhuan Liao, Claude Férec, Arnaud Boulling, Matthew J. Hayden, Jin-Huan Lin, Emmanuelle Masson, David N. Cooper, Jian-Min Chen, Université de Brest (UBO), Second Military Medical University, Shanghai Institute of Pancreatic Diseases [Shanghai, China], Service de Genetique Clinique, CHRU Morvan, 29609, Brest, INSERM U1078, Cardiff University's Brain Research Imaging Centre [Cardiff] (CUBRIC), School of Psychology [Cardiff University], Cardiff University-Cardiff University, China Scholarship Council 201706580018, and Institut National de la Sante et de la Recherche Medicale (Inserm)
Subjects: Gene splicing, full-length gene splicing assay, DNA Mutational Analysis, Human Gene Mutation Database, +2C &gt, Biology, Genome, Dystrophin, 03 medical and health sciences, Genetics, Humans, splice, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Genetics (clinical), 030304 developmental biology, C variant, 0303 health sciences, [SDV.GEN]Life Sciences [q-bio]/Genetics, Functional analysis, 030305 genetics & heredity, +2T &gt, 5 ' splice site, Pathogenicity, Cell culture, RNA splicing, Mutation, Human genome, RNA Splice Sites, T variant, noncanonical GC dinucleotide, Thrombospondins
Abstract: International audience; In the human genome, most 5 ' splice sites (similar to 99%) employ the canonical GT dinucleotide whereas a small minority (similar to 1%) use the noncanonical GC dinucleotide. The functionality and pathogenicity of 5 ' splice site GT>GC (+2T>C) variants have been extensively studied but we know very little about 5 ' splice site GC>GT (+2C>T) variants. Herein, we have addressed this deficiency by performing a meta-analysis of reported +2C>T "pathogenic" variants together with a functional analysis of engineered +2C>T substitutions using a cell culture-based full-length gene splicing assay. Our results establish proof of concept that +2C>T variants are qualitatively different from +2T>C variants in terms of their functionality and suggest that, in sharp contrast to +2T>C variants, most if not all +2C>T variants have no pathological relevance. Our findings have important implications for interpreting the clinical relevance of +2C>T variants and understanding the evolutionary switching between GT and GC 5 ' splice sites in mammalian genomes.
Published: 2020

14. Tractostorm: The what, why, and how of tractography dissection reproducibility

Author: Maxime Chamberland, Silvio Sarubbo, Janice Hau, Felix C. Morency, Laurent Petit, Kristofer Pomiecko, Quentin Chenot, Ilyess Zemmoura, Chantal M. W. Tax, Maxime Descoteaux, Alessandro Daducci, Kelly Glavin, Muhamed Barakovic, Guillaume Theaud, François Rheault, Francesco Corrivetti, Chiara Maffei, Kesshi Jordan, Alessandro De Benedictis, Gabriel Girard, Eduardo Caverzasi, Nil Goyette, Franco Pestilli, Philippe Poulin, David Romascano, Sandip S. Panesar, Institut Supérieur de l'Aéronautique et de l'Espace - ISAE-SUPAERO (FRANCE), Sherbrooke Connectivity Imaging Lab [Sherbrooke] (SCIL), Département d'informatique [Sherbrooke] (UdeS), Faculté des sciences [Sherbrooke] (UdeS), Université de Sherbrooke (UdeS)-Université de Sherbrooke (UdeS)-Faculté des sciences [Sherbrooke] (UdeS), Université de Sherbrooke (UdeS)-Université de Sherbrooke (UdeS), Department of Neuroscience and Neurorehabilitation, Neurosurgery Unit, Bambino Ges  u Children’s Hospital – IRCCS, 4 Piazza Sant’Onofrio, Roma, 00165, Italy, Department of Computer Science [Verona] (UNIVR | DI), Università degli studi di Verona = University of Verona (UNIVR), Athinoula A. Martinos Center for Biomedical Imaging, Harvard Medical School [Boston] (HMS)-Massachusetts General Hospital [Boston], Cardiff University's Brain Research Imaging Centre [Cardiff] (CUBRIC), School of Psychology [Cardiff University], Cardiff University-Cardiff University, Signal Processing Laboratory [Lausanne] (LTS5), Ecole Polytechnique Fédérale de Lausanne (EPFL), Department of Neurology (University of California : San Francisco), University of California [San Francisco] (UC San Francisco), University of California (UC)-University of California (UC), Imeka Solutions, Sherbrooke, Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Department of Psychological and Brain Sciences, Indiana University, Imagerie et cerveau (iBrain - Inserm U1253 - UNIV Tours ), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Brain Development Imaging Laboratories, Department of Psychology, San Diego State University, Learning Research & Development Center (LRDC), University of Pittsburgh, Institut Supérieur de l'Aéronautique et de l'Espace (ISAE-SUPAERO), Department of Neurosurgery [Stanford], Stanford Medicine, Stanford University-Stanford University, Department of Neurosciences, Division of Neurosurgery, 'S. Chiara' Hospital, Trento APSS – 9 Largo Medaglie D’Oro, Trento, 38122, Italy, Groupe d'imagerie neurofonctionnelle (GIN), Institut des Maladies Neurodégénératives [Bordeaux] (IMN), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Petit, Laurent, University of Verona (UNIVR), Massachusetts General Hospital [Boston]-Harvard Medical School [Boston] (HMS), University of California [San Francisco] (UCSF), University of California-University of California, Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM), ISAE-SUPAERO, Université de Toulouse, Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut des Maladies Neurodégénératives [Bordeaux] (IMN), and Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Standardization, Computer science, diffusion tractography, tractography, computer.software_genre, diffusion MRI, 0302 clinical medicine, inter-rater, Segmentation, Research Articles, Observer Variation, Radiological and Ultrasound Technology, Dissection, 05 social sciences, White matter, hippocampal segmentation, Bundle segmentation, White Matter, Reproducibility, intra-rater, 3. Good health, Diffusion Tensor Imaging, inter‐rater, Neurology, manual segmentation, Anatomy, adni harmonized protocol, bundle segmentation, Tractography, fractional anisotropy, Research Article, Intra‐rater, Machine learning, 050105 experimental psychology, Diffusion MRI, 03 medical and health sciences, fiber tracking, Fractional anisotropy, Humans, 0501 psychology and cognitive sciences, Radiology, Nuclear Medicine and imaging, intra‐rater, reproducibility, Protocol (science), multi-atlas segmentation, business.industry, [SCCO.NEUR]Cognitive science/Neuroscience, Inter‐rater, [SCCO.NEUR] Cognitive science/Neuroscience, Neurosciences, Reproducibility of Results, cross-correlation, white-matter pathways, Inter-rater reliability, Diffusion Magnetic Resonance Imaging, Bundle, tensor imaging tractography, Anisotropy, Neurology (clinical), Artificial intelligence, business, computer, 030217 neurology & neurosurgery
Abstract: Investigative studies of white matter (WM) brain structures using diffusion MRI (dMRI) tractography frequently require manual WM bundle segmentation, often called “virtual dissection.” Human errors and personal decisions make these manual segmentations hard to reproduce, which have not yet been quantified by the dMRI community. It is our opinion that if the field of dMRI tractography wants to be taken seriously as a widespread clinical tool, it is imperative to harmonize WM bundle segmentations and develop protocols aimed to be used in clinical settings. The EADC‐ADNI Harmonized Hippocampal Protocol achieved such standardization through a series of steps that must be reproduced for every WM bundle. This article is an observation of the problematic. A specific bundle segmentation protocol was used in order to provide a real‐life example, but the contribution of this article is to discuss the need for reproducibility and standardized protocol, as for any measurement tool. This study required the participation of 11 experts and 13 nonexperts in neuroanatomy and “virtual dissection” across various laboratories and hospitals. Intra‐rater agreement (Dice score) was approximately 0.77, while inter‐rater was approximately 0.65. The protocol provided to participants was not necessarily optimal, but its design mimics, in essence, what will be required in future protocols. Reporting tractometry results such as average fractional anisotropy, volume or streamline count of a particular bundle without a sufficient reproducibility score could make the analysis and interpretations more difficult. Coordinated efforts by the diffusion MRI tractography community are needed to quantify and account for reproducibility of WM bundle extraction protocols in this era of open and collaborative science.
Published: 2020

15. The scale of virtual environment influences human perception of distance

Author: Morice, Antoine H. P., Victor Garruchet, Nessrine Harbaoui, Cedric Goulon, Martin Bossard, Daniel Mestre, Franck Ruffier, Institut des Sciences du Mouvement Etienne Jules Marey (ISM), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), School of Psychology [Cardiff University], Cardiff University, Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), and MORICE, Antoine
Subjects: Tunnel, [SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior, Odometry, Optic flow, [SCCO.NEUR]Cognitive science/Neuroscience, [SCCO.NEUR] Cognitive science/Neuroscience, [INFO.INFO-GR] Computer Science [cs]/Graphics [cs.GR], [SDV.NEU.PC] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior, Virtual Reality, CAVE, Geometry, Condensed Matter::Mesoscopic Systems and Quantum Hall Effect, [INFO.INFO-GR]Computer Science [cs]/Graphics [cs.GR], Scale, Condensed Matter::Superconductivity
Abstract: International audience; Participants were instructed to reproduce a previously observed distance by travelling passively at a constant velocity into straight textured tunnels in a CAVE. The diameter of the tunnel into which participants travelled and the egocentric distance to be reproduced were manipulated. Participants' distance perception was sensitive to the tunnel's scale, distance being overestimated with the tunnel's diameter increase and underestimated with the tunnel's diameter decrease.
Published: 2019

16. High phi as a probe of global motion processing

Author: Martin Bossard, Simon Rushton, Mark Wexler, School of Psychology [Cardiff University], and Cardiff University
Subjects: Physics, business.industry, 05 social sciences, Motion processing, 050105 experimental psychology, Sensory Systems, [SCCO]Cognitive science, 03 medical and health sciences, Ophthalmology, 0302 clinical medicine, [SCCO.PSYC]Cognitive science/Psychology, 0501 psychology and cognitive sciences, Computer vision, Artificial intelligence, business, ComputingMilieux_MISCELLANEOUS, 030217 neurology & neurosurgery
Abstract: International audience
Published: 2021

17. Brainhack: Developing a culture of open, inclusive, community-driven neuroscience

Author: Selim Melvin Atay, Iska Moxon-Emre, Anders Eklund, Paula P. Brooks, Nandita Vijayakumar, Anibal Sólon Heinsfeld, Jean-Baptiste Poline, Yaroslav O. Halchenko, David Meunier, Daniela M. Hohmann, Martin Szinte, Arshitha Basavaraj, Andrija Štajduhar, Link Tejavibulya, Michael Dayan, Anisha Keshavan, Chao Jiang, Felix Hoffstaedter, Michael P. Milham, Davide Momi, Hua Xie, Ai Wern Chung, Georg Langs, Hao-Ting Wang, Xenia Kobeleva, Robert Oostenveld, Thomas G. Close, Lena Dorfschmidt, Jesse A. Brown, Serge Koudoro, J.P. Manzano-Patron, Isil P. Bilgin, Shreyas Fadnavis, Sylvain Takerkart, R. Cameron Craddock, Stephan Heunis, Scott Peltier, Kathryn Berluti, Hayli Spence, Pablo F. Damasceno, David H. O’Connor, Eleftherios Garyfallidis, Eugene P. Duff, Rudolph Pienaar, Nicolas Traut, AmanPreet Badhwar, Ali R. Khan, Marissa Laws, Abigail S. Greene, Richard A. I. Bethlehem, Angela R. Laird, Krista DeStasio, Ina Thome, Camille Maumet, Alexandru D. Iordan, P. Christiaan Klink, Damion V. Demeter, John A. Onofrey, Cassandra D. Gould van Praag, Jakub Vohryzek, Suzanne T. Witt, Aysha Motala, Valerie Hayot-Sasson, Geetika Gupta, Alexandre Rosa Franco, John W. VanMeter, Michel Thiebaut de Schotten, James M. Shine, Lucina Q. Uddin, Thomas S. Hartmann, Guillaume Flandin, Clara Moreau, Tomislav Lipic, Claire Bradley, Fernando A. Barrios, Daniel S. Margulies, R. Austin Benn, Sofie Van Den Bossche, Lydia Riedl, Xihe Xie, Christopher R. Madan, Roberto Toro, Viviana Siless, Fabrizio De Vico Fallani, Nikoloz Sirmpilatze, Emily Olafson, Anqi Qiu, Theresa W. Cheng, Valentina Borghesani, Sidhant Chopra, Claire Cury, Giorgio Marinato, Horea-Ioan Ioanas, Giorgia Cona, Michael Joseph, Angela Tam, Mathias Scharinger, Daniel A. Handwerker, Katherine L. Bottenhorn, Sina Mansour L, Kathryn L. Mills, Christopher J. Markiewicz, Elizabeth Levitis, Cyril Pernet, Stephanie J. Forkel, Agah Karakuzu, Edwina R Orchard, Sarah L. Dziura, Saige Rutherford, Kamalaker Dadi, Enrico Glerean, Desiree Lussier, Davide Poggiali, Molly Simmonite, Jason Kai, Jessica Flannery, Ting Xu, Jon Haitz Legarreta, Nasim Anousheh, Marco Bedini, Tristan Glatard, Thomas E. Nichols, Joscelin Rocha-Hidalgo, Erin W. Dickie, Dipankar Bachar, Malin Sandström, Xi-Nian Zuo, Pedro Pinheiro-Chagas, Laura C. Rice, Jakša Vukojević, Javier Gonzalez-Castillo, José C. García Alanis, Lorenzo Pasquini, Yu-Fang Yang, Matteo Mancini, Deena Shariq, Chao-Gan Yan, Laura Tomaz da Silva, César Caballero-Gaudes, Yasmine Bassil, Aurina Arnatkeviciute, Dustin Scheinost, Satrajit S. Ghosh, Gaël Varoquaux, Etienne Combrisson, Bramsh Qamar Chandio, Kelly Garner, Tiago Quendera, Patrick Friedrich, Shawn A. Rhoads, Roxane Licandro, Elizabeth DuPre, Aki Nikolaidis, Simon Schwab, Stephanie Noble, Guillaume Auzias, Daniel J. Lurie, Mahboobeh Parsapoor, Eneko Uruñuela, Andrew Doyle, Peer Herholz, Saampras Ganesan, Vincent Koppelmans, Corey Horien, Samir Das, Junaid S. Merchant, Siyuan Gao, Matheus Marcon, Nathalia Bianchini Esper, B.T. Thomas Yeo, Katja Heuer, Caroline O’Brien, Micaela Y. Chan, Sook-Lei Liew, Lindsay D. Oliver, Kirstie Whitaker, Christoph Vogelbacher, Dylan M. Nielson, Krisanne Litinas, Dorien C. Huijser, Pierre Bellec, R. Todd Constable, David N. Kennedy, Julia Sprenger, Lea-Theresa Mais, Oscar Esteban, Patrick J. Park, Patrick Callahan, Christopher R. Nolan, Johanna Bayer, Guillaume Dumas, Elise Bannier, Elizabeth A. McDevitt, Ariel Rokem, Samuel A. Nastase, Olivia W. Stanley, Ruggero Basanisi, Daniele Marinazzo, Gregory Kiar, Lisa Novello, Samuel Guay, John C. Flournoy, Stefano Moia, Kendra Oudyk, Fang-Cheng Yeh, Gustav Nilsonne, Thomas B. Shaw, Steve Wideman, Saskia Bollmann, Steffen Bollmann, Julia M. Huntenburg, Augusto Buchweitz, Matteo Visconti di Oleggio Castello, Dimitra Maoutsa, Lucy B. Whitmore, Catherine Alice Hahn, Antonino Vallesi, Remi Gau, Felipe Meneguzzi, Université Catholique de Louvain = Catholic University of Louvain (UCL), Yale University [New Haven], Max Planck Institute for Human Cognitive and Brain Sciences [Leipzig] (IMPNSC), Max-Planck-Gesellschaft, Florida International University [Miami] (FIU), University of Reading (UOR), University of Würzburg, Champalimaud Centre for the Unknown [Lisbon], University of Melbourne, University of Cambridge [UK] (CAM), Georgetown University [Washington] (GU), Philipps Universität Marburg = Philipps University of Marburg, Université de Montréal (UdeM), University College of London [London] (UCL), University of Sussex, Universiteit Gent = Ghent University (UGENT), German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Université de Sherbrooke (UdeS), Middle East Technical University [Ankara] (METU), McGill University = Université McGill [Montréal, Canada], Modelling brain structure, function and variability based on high-field MRI data (PARIETAL), Service NEUROSPIN (NEUROSPIN), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Universiteit Leiden, Karolinska Institutet [Stockholm], Princeton University, Universität Zürich [Zürich] = University of Zurich (UZH), University of the Basque Country/Euskal Herriko Unibertsitatea (UPV/EHU), University medical center and campus biotech Geneva, Emory University [Atlanta, GA], Cardiff University's Brain Research Imaging Centre [Cardiff] (CUBRIC), School of Psychology [Cardiff University], Cardiff University-Cardiff University, The University of Sydney, Weill Cornell Medicine [Cornell University], Cornell University [New York], Università degli Studi di Padova = University of Padua (Unipd), Jülich Research Centre, University of Texas at Austin [Austin], Institut Pasteur [Paris] (IP), Centre de Recherche Interdisciplinaire / Center for Research and Interdisciplinarity [Paris, France] (CRI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Basque Center on Cognition Brain and Language [Gipuzkoa, Espagne] (BCBL), Linköping University (LIU), University of Queensland [Brisbane], University of New South Wales [Sydney] (UNSW), Universidad Nacional Autónoma de México = National Autonomous University of Mexico (UNAM), University of Maryland [College Park], University of Maryland System, University of Washington [Seattle], Harvard Medical School [Boston] (HMS), Child Mind Institute, University of Western Ontario (UWO), Indiana University [Bloomington], Indiana University System, Monash university, Institut de Neurosciences de la Timone (INT), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Neuroimagerie: méthodes et applications (Empenn), Institut National de la Santé et de la Recherche Médicale (INSERM)-Inria Rennes – Bretagne Atlantique, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-SIGNAUX ET IMAGES NUMÉRIQUES, ROBOTIQUE (IRISA-D5), Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), National Institute of Mental Health (NIMH), Università degli Studi di Trento (UNITN), Centro Nacional de Investigaciones Cardiovasculares Carlos III [Madrid, Spain] (CNIC), Instituto de Salud Carlos III [Madrid] (ISC), Queensland University of Technology [Brisbane] (QUT), University of California [San Francisco] (UC San Francisco), University of California (UC), Universidade Federal do Rio Grande do Sul [Porto Alegre] (UFRGS), University of Texas at Dallas [Richardson] (UT Dallas), University of Oregon [Eugene], Monash University [Melbourne], Boston Children's Hospital, Algorithms, models and methods for images and signals of the human brain (ARAMIS), Sorbonne Université (SU)-Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut des Maladies Neurodégénératives [Bordeaux] (IMN), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Neuroimagerie: méthodes et applications (EMPENN), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-SIGNAL, IMAGE ET LANGAGE (IRISA-D6), Chinese Academy of Sciences [Beijing] (CAS), Beijing Normal University (BNU), This project has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement no. 867458 awarded to Julia M. Huntenburg, from ANR-19-DATA-0025 NeuroWebLab for Katja Heuer, Roberto Toro, and Nicholas Traut, and from NIH K00MH122372 for Stephanie Noble., Brainhack Community: Nasim Anousheh, Aurina Arnatkeviciute, Guillaume Auzias, Dipankar Bachar, Elise Bannier, Ruggero Basanisi, Arshitha Basavaraj, Marco Bedini, Pierre Bellec, R Austin Benn, Kathryn Berluti, Steffen Bollmann, Saskia Bollmann, Claire Bradley, Jesse Brown, Augusto Buchweitz, Patrick Callahan, Micaela Y Chan, Bramsh Q Chandio, Theresa Cheng, Sidhant Chopra, Ai Wern Chung, Thomas G Close, Etienne Combrisson, Giorgia Cona, R Todd Constable, Claire Cury, Kamalaker Dadi, Pablo F Damasceno, Samir Das, Fabrizio De Vico Fallani, Krista DeStasio, Erin W Dickie, Lena Dorfschmidt, Eugene P Duff, Elizabeth DuPre, Sarah Dziura, Nathalia B Esper, Oscar Esteban, Shreyas Fadnavis, Guillaume Flandin, Jessica E Flannery, John Flournoy, Stephanie J Forkel, Alexandre R Franco, Saampras Ganesan, Siyuan Gao, José C García Alanis, Eleftherios Garyfallidis, Tristan Glatard, Enrico Glerean, Javier Gonzalez-Castillo, Cassandra D Gould van Praag, Abigail S Greene, Geetika Gupta, Catherine Alice Hahn, Yaroslav O Halchenko, Daniel Handwerker, Thomas S Hartmann, Valérie Hayot-Sasson, Stephan Heunis, Felix Hoffstaedter, Daniela M Hohmann, Corey Horien, Horea-Ioan Ioanas, Alexandru Iordan, Chao Jiang, Michael Joseph, Jason Kai, Agah Karakuzu, David N Kennedy, Anisha Keshavan, Ali R Khan, Gregory Kiar, P Christiaan Klink, Vincent Koppelmans, Serge Koudoro, Angela R Laird, Georg Langs, Marissa Laws, Roxane Licandro, Sook-Lei Liew, Tomislav Lipic, Krisanne Litinas, Daniel J Lurie, Désirée Lussier, Christopher R Madan, Lea-Theresa Mais, Sina Mansour L, J P Manzano-Patron, Dimitra Maoutsa, Matheus Marcon, Daniel S Margulies, Giorgio Marinato, Daniele Marinazzo, Christopher J Markiewicz, Camille Maumet, Felipe Meneguzzi, David Meunier, Michael P Milham, Kathryn L Mills, Davide Momi, Clara A Moreau, Aysha Motala, Iska Moxon-Emre, Thomas E Nichols, Dylan M Nielson, Gustav Nilsonne, Lisa Novello, Caroline O'Brien, Emily Olafson, Lindsay D Oliver, John A Onofrey, Edwina R Orchard, Kendra Oudyk, Patrick J Park, Mahboobeh Parsapoor, Lorenzo Pasquini, Scott Peltier, Cyril R Pernet, Rudolph Pienaar, Pedro Pinheiro-Chagas, Jean-Baptiste Poline, Anqi Qiu, Tiago Quendera, Laura C Rice, Joscelin Rocha-Hidalgo, Saige Rutherford, Mathias Scharinger, Dustin Scheinost, Deena Shariq, Thomas B Shaw, Viviana Siless, Molly Simmonite, Nikoloz Sirmpilatze, Hayli Spence, Julia Sprenger, Andrija Stajduhar, Martin Szinte, Sylvain Takerkart, Angela Tam, Link Tejavibulya, Michel Thiebaut de Schotten, Ina Thome, Laura Tomaz da Silva, Nicolas Traut, Lucina Q Uddin, Antonino Vallesi, John W VanMeter, Nandita Vijayakumar, Matteo Visconti di Oleggio Castello, Jakub Vohryzek, Jakša Vukojević, Kirstie Jane Whitaker, Lucy Whitmore, Steve Wideman, Suzanne T Witt, Hua Xie, Ting Xu, Chao-Gan Yan, Fang-Cheng Yeh, B T Thomas Yeo, Xi-Nian Zuo, ANR-19-DATA-0025,NeuroWebLab,Un laboratoire de neuroscience collectif: Au delà de FAIR(2019), European Project: 867458,LC-FMR, Maumet, Camille, Un laboratoire de neuroscience collectif: Au delà de FAIR - - NeuroWebLab2019 - ANR-19-DATA-0025 - DONNEES - VALID, Brainhack: Developing a culture of open, inclusive, community-driven neuroscience - LC-FMR - 867458 - INCOMING, Leiden University, Weill Cornell Medicine [New York], Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPC), Universiteit Gent = Ghent University [Belgium] (UGENT), University Hospital Bonn, Sherbrooke Connectivity Imaging Lab [Sherbrooke] (SCIL), Département d'informatique [Sherbrooke] (UdeS), Faculté des sciences [Sherbrooke] (UdeS), Université de Sherbrooke (UdeS)-Université de Sherbrooke (UdeS)-Faculté des sciences [Sherbrooke] (UdeS), Université de Sherbrooke (UdeS)-Université de Sherbrooke (UdeS), Videos and Images Theory and Analytics Laboratory (VITAL), Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Service NEUROSPIN (NEUROSPIN), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Erasmus University Rotterdam, Origami (Origami), Laboratoire d'InfoRmatique en Image et Systèmes d'information (LIRIS), Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-École Centrale de Lyon (ECL), Université de Lyon-Université Lumière - Lyon 2 (UL2)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Université Lumière - Lyon 2 (UL2), Princeton Neuroscience Institute [Princeton], Human Neuroscience Platform, Brighton and Sussex Medical School (BSMS), Azienda Ospedale Università di Padova = Hospital-University of Padua (AOUP), Institute of Neuroscience and Medicine [Jülich] (INM-1), Département de Neuroscience - Department of Neuroscience, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPC), Queensland Brain Institute, Universidad Nacional Autónoma de México (UNAM), Radboud university [Nijmegen], McGovern Institute for Brain Research [Cambridge], Massachusetts Institute of Technology (MIT), The Brainhack Community - https://pubmed.ncbi.nlm.nih.gov/33932337, Philipps University of Marburg, University of the Basque Country [Bizkaia] (UPV/EHU), Universita degli Studi di Padova, Philipps Universität Marburg, Institut Pasteur [Paris], Empenn, Université de Bretagne Sud (UBS)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National de Recherche en Informatique et en Automatique (Inria)-École normale supérieure - Rennes (ENS Rennes)-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-CentraleSupélec-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Bretagne Sud (UBS)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-École normale supérieure - Rennes (ENS Rennes)-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), University of California [San Francisco] (UCSF), University of California, Geochemistry, and University of Padova [Padova, Italy]
Subjects: 0301 basic medicine, Open science, Community building, Best practice, Neuroscience(all), Brainhack, Article, neuroscience, 03 medical and health sciences, 0302 clinical medicine, best practices, collaboration, community building, hackathon, inclusivity, open science, reproducibility, training, Congresses as Topic, Neurosciences, Practice Guidelines as Topic, Communication, Internet, Research community, Medical Bioscience, Psychology, ddc:610, Sociology, Brainhack Community, Training, Neurology & Neurosurgery, Scientific progress, organization & administration [Neurosciences], General Neuroscience, [SCCO.NEUR]Cognitive science/Neuroscience, [SCCO.NEUR] Cognitive science/Neuroscience, Medicinsk biovetenskap, 030104 developmental biology, [SDV.IB]Life Sciences [q-bio]/Bioengineering, Cognitive Sciences, Engineering ethics, 030217 neurology & neurosurgery
Abstract: Available online 30 April 2021. Brainhack is an innovative meeting format that promotes scientific collaboration and education in an open, inclusive environment. This NeuroView describes the myriad benefits for participants and the research community and how Brainhacks complement conventional formats to augment scientific progress. The present manuscript is part of a growing community effort to collate Brainhack-related insights and expertise into a Jupyter Book (http://brainhack.org/brainhack_jupyter_book/) that will serve as a centralized set of resources for the community; we acknowledge all the individuals who contributed and will make ongoing contributions to these resources. A pre-print version of the present manuscript is available as part of the Jupyter Book. Moreover, we would like to acknowledge all Brainhack organizers, supporters, presenters, and participants for their contribution to growing and maintaining this community. The benefits described in this manuscript would not be possible without them. We also thank all institutions, labs, and organizations who have helped this community grow, meet in stimulating environments, and add an excellent educational resource pool and agenda. With an expanding community, Brainhack’s support network keeps growing, and we thank all labs and individual researchers for their dedication and expertise offered to this community (see http://brainhack.org/brainhack_jupyter_book/acknowledgments.html for a full list of individual acknowledgments; an updated list will be maintained in the Jupyter Book). Grants and funding bodies: This project has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement no. 867458 awarded to Julia M. Huntenburg; from ANR-19-DATA-0025 NeuroWebLab for Katja Heuer, Roberto Toro, and Nicholas Traut; and from NIH K00MH122372 for Stephanie Noble. The Brainhack Community member list and contributions of the different authors are detailed at http://brainhack.org/brainhack_jupyter_book/contributors.html. Our crediting system is described here: http://brainhack.org/brainhack_jupyter_book/neuroview_authorship-agreement.html.
Published: 2021

18. The Superoanterior Fasciculus (SAF): a novel white matter pathway in the human brain?

Author: Francesco Corsini, Szabolcs David, John Evans, Francesco Corrivetti, Anneriet M. Heemskerk, Max A. Viergever, Alexander Leemans, Hubertus Axer, Emmanuel Mandonnet, Tomáš Paus, Alessandro De Benedictis, Silvio Sarubbo, Michel Thiebaut de Schotten, Derek K. Jones, Laurent Petit, Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Image sciences institute - University of Utrecht (ISI), University Medical Center [Utrecht], Hôpital Lariboisière, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Lariboisière-Université Paris Diderot - Paris 7 (UPD7), Centre for Neuroimaging Sciences, Institute of Psychiatry, King‘s College London, Groupe d'imagerie neurofonctionnelle (GIN), Institut des Maladies Neurodégénératives [Bordeaux] (IMN), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), School of Psychology [Cardiff University], Cardiff University, University of Toronto, Université Paris Diderot - Paris 7 (UPD7)-Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut des Maladies Neurodégénératives [Bordeaux] (IMN), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Hôpital Lariboisière-Fernand-Widal [APHP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)
Subjects: 0301 basic medicine, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, Computer science, neuroanatomy, brain, Neuroscience (miscellaneous), Polarized light imaging, fiber tractography, Diffusion MRI, lcsh:RC321-571, lcsh:QM1-695, White matter, diffusion MRI, 03 medical and health sciences, Cellular and Molecular Neuroscience, superoanterior fasciculus, [SCCO]Cognitive science, 0302 clinical medicine, Fasciculus, [SDV.MHEP.AHA]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], medicine, Journal Article, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, ComputingMilieux_MISCELLANEOUS, Original Research, medicine.diagnostic_test, biology, Dissection, [SCCO.NEUR]Cognitive science/Neuroscience, Fiber tractography, Magnetic resonance imaging, lcsh:Human anatomy, Human brain, biology.organism_classification, Superoanterior fasciculus, 030104 developmental biology, medicine.anatomical_structure, Frontal lobe, dissection, Anatomy, Neuroscience, 030217 neurology & neurosurgery, polarized light imaging, Neuroanatomy
Abstract: International audience; Fiber tractography (FT) using diffusion magnetic resonance imaging (dMRI) is widely used for investigating microstructural properties of white matter (WM) fiber-bundles and for mapping structural connections of the human brain. While studying the architectural configuration of the brain's circuitry with FT is not without controversy, recent progress in acquisition, processing, modeling, analysis, and visualization of dMRI data pushes forward the reliability in reconstructing WM pathways. Despite being aware of the well-known pitfalls in analyzing dMRI data and several other limitations of FT discussed in recent literature, we present the superoanterior fasciculus (SAF), a novel bilateral fiber tract in the frontal region of the human brain that-to the best of our knowledge-has not been documented. The SAF has a similar shape to the anterior part of the cingulum bundle, but it is located more frontally. To minimize the possibility that these FT findings are based on acquisition or processing artifacts, different dMRI data sets and processing pipelines have been used to describe the SAF. Furthermore, we evaluated the configuration of the SAF with complementary methods, such as polarized light imaging (PLI) and human brain dissections. The FT results of the SAF demonstrate a long pathway, consistent across individuals, while the human dissections indicate fiber pathways connecting the postero-dorsal with the antero-dorsal cortices of the frontal lobe.
Published: 2019

19. High-Phi and Three-Dimensional Global Motion Processing

Author: Martin Bossard, Simon Rushton, Bossard, Martin, School of Psychology [Cardiff University], and Cardiff University
Subjects: [SCCO]Cognitive science, [SCCO.PSYC]Cognitive science/Psychology, [SCCO.PSYC] Cognitive science/Psychology, [SCCO] Cognitive science
Abstract: International audience; Wexler et al. (2013) discovered a visually remarkable effect they called “high-phi.” When a rotating motion pattern (an inducer) is followed by a few frames of noise, a very fast rotational jump of the stimulus is perceived. We were interested in nature of the high-phi effect, in particular, its relationship to 3D global motion (optic flow) processing.We first established the high-phi effect works with random dots (the original demonstration using textured surfaces). Then, we tested whether the effect occurs with radial motion as well as circular motion (yes). Next, we conducted a series of experiments in which we removed a portion (wedge) of the stimuli and used a probe to test for a high-phi effect in the unstimulated region (cf., the phantom motion after effect).We tested (a) whether the effect occurs in the unstimulated wedge (yes); (b) whether, like the original high-phi effect, the perceived jump direction and magnitude changes as a function of the inducer duration (yes but); (c) whether the effect stores, that is, still occurs if there is a delay between the inducer and the probe presentation (yes, over the period we have tested); (d) whether the effect follows optic flow geometry, whether the magnitude of the effect increases with distance from the focus of expansion (yes but). We are currently exploring whether we can generate a stereo motion-in-depth version of the effect, and whether the magnitude of the effect decreases with the size of the stimuli (cf., surround suppression).ReferencesWexler, M., Glennerster, A., Cavanagh, P., Ito, H., & Seno, T. (2013). Default perception of high speed motion. Proceedings of the National Academy of Sciences, 110, 7080–7085.
Published: 2019

20. PERCEPTION VISUELLE DU MOUVEMENT PROPRE : Effets des mouvements de la tête durant la marche sur l'estimation de la distance parcourue à partir du flux optique

Author: Martin Bossard, School of Psychology [Cardiff University], Cardiff University, Aix-Marseile Université, and Daniel Mestre
Subjects: [SCCO]Cognitive science, intégration de trajet, travelled distance perception, perception du mouvement propre, [SCCO.PSYC]Cognitive science/Psychology, optic flow, path integration, perception de la distance parcourue, flux optique, self-motion perception
Abstract: When exploring their environment, humans and other animals have the ability to use many sources of information to estimate the distance they travel. Several studies have shown that optic flow is a significant cue to perceive distance travelled. Furthermore, it was found that adding various viewpoint oscillations to a purely translational optic flow, simulating forward self-motion, modulated this perception. In a series of experiments, we tested whether the perception of distance travelled was also affected by viewpoint oscillation, similar to head motion during natural walking. A first series of experiments, participants were exposed to an immersive optic flow simulating forward self-motion and they were asked to indicate when they thought they had reached the remembered position of a previously seen target. The main conclusion from these experiments is that viewpoint oscillations improve the perception of distance travelled. Moreover, this effect appears to be linked to an increase in global retinal motion. However, the "ecological" contribution cannot be ruled out. Manipulating different viewpoint oscillation frequencies showed that the optimal performance was observed for a range of frequencies close to that observed for the head motion during natural walking. Two further experiments aimed to test whether the idiosyncrasy of viewpoint oscillations affects the perception of distance travelled in stationary observers and whether the absence of their own viewpoint oscillation played an important role in subjects’ estimates, while they were walking on a treadmill. And finally, in a last experiment we tried to develop a dynamic measure of distance travelled to a previously seen target, with a continuous pointing task method. Overall, our results show that viewpoint oscillations play an important role in visual self-motion perception and that several parameters (including visual information, proprioceptive information and ecological aspects of natural walking) seem to be involved in this process.; Lorsqu’ils explorent leur environnement, les humains comme les autres animaux ont la capacité d’utiliser de nombreuses sources d’information afin d’estimer la distance qu’ils parcourent. De nombreuses études ont montré que le flux optique est un indice important dans la perception de la distance parcourue. De plus, il a été montré que l’ajout d’un point de vue oscillant à une simulation visuelle de mouvement propre vers l’avant modulait cette perception par rapport à une simulation visuelle de mouvement purement linéaire. A travers ce travail doctoral, nous nous sommes intéressés à tester si la perception de la distance parcourue était également affectée par un point de vue oscillant, mimant de manière plus ou moins fidèle les mouvements de la tête lors de la marche. Dans une première série d’expériences, il était demandé aux participants, confrontés à un flux optique immersif simulant leur propre mouvement vers l’avant, d’indiquer quand ils pensaient avoir atteint la position d’une cible distante initialement perçue. La conclusion principale de ces expérimentations est qu’un point de vue oscillant améliore la perception de la distance parcourue. De plus, cet effet semble être lié à une augmentation du mouvement rétinien provoqué par l’oscillation du point de vue. Toutefois la contribution « écologique » ne peut pas être exclue. En effet, la manipulation de la fréquence de cette oscillation montre que les performances optimales sont observées pour une gamme de fréquences proche de celle observée pour le mouvement de la tête résultant de la fréquence de pas pendant la marche naturelle. Deux expériences subséquentes se sont intéressées à déterminer si le caractère idiosyncratique du point de vue oscillant affectait la perception de la distance parcourue d’observateurs stationnaires et si l’absence de ces oscillations jouait un rôle important dans l’estimation de la distance parcourue lorsqu’ils marchaient sur un tapis roulant. Enfin, dans une dernière expérience nous avons essayé de développer une mesure dynamique de la distance parcourue à travers l’utilisation d’une tâche demandant aux participants de pointer continuellement la position d’une cible distante initialement perçue. Dans l’ensemble, nos résultats montrent qu’un point de vue oscillant joue un rôle important dans la perception visuelle du mouvement propre et que de nombreux paramètres semblent être impliqués dans ce processus, incluant les informations visuelles et proprioceptives mais également l’aspect écologique de la marche naturelle.
Published: 2018

21. Analysis of shared heritability in common disorders of the brain

Author: Brainstorm Consortium, Anttila, Verneri, Bulik-Sullivan, Brendan, Finucane, Hilary K, Walters, Raymond K, Bras, Jose, Duncan, Laramie, Escott-Price, Valentina, Falcone, Guido J, Gormley, Padhraig, Malik, Rainer, Patsopoulos, Nikolaos A, Ripke, Stephan, Wei, Zhi, Yu, Dongmei, Lee, Phil H, Turley, Patrick, Grenier-Boley, Benjamin, Chouraki, Vincent, Kamatani, Yoichiro, Berr, Claudine, Letenneur, Luc, Hannequin, Didier, Amouyel, Philippe, Boland, Anne, Deleuze, Jean-François, Duron, Emmanuelle, Vardarajan, Badri N, Reitz, Christiane, Goate, Alison M, Huentelman, Matthew J, Kamboh, M Ilyas, Larson, Eric B, Rogaeva, Ekaterina, St George-Hyslop, Peter, Hakonarson, Hakon, Kukull, Walter A, Farrer, Lindsay A, Barnes, Lisa L, Beach, Thomas G, Demirci, F Yesim, Head, Elizabeth, Hulette, Christine M, Jicha, Gregory A, Kauwe, John SK, Kaye, Jeffrey A, Leverenz, James B, Levey, Allan I, Lieberman, Andrew P, Pankratz, Vernon S, Poon, Wayne W, Quinn, Joseph F, Saykin, Andrew J, Schneider, Lon S, Smith, Amanda G, Sonnen, Joshua A, Stern, Robert A, Van Deerlin, Vivianna M, Van Eldik, Linda J, Harold, Denise, Russo, Giancarlo, Rubinsztein, David C, Bayer, Anthony, Tsolaki, Magda, Proitsi, Petra, Fox, Nick C, Hampel, Harald, Owen, Michael J, Mead, Simon, Passmore, Peter, Morgan, Kevin, Nöthen, Markus M, Rossor, Martin, Lupton, Michelle K, Hoffmann, Per, Kornhuber, Johannes, Lawlor, Brian, McQuillin, Andrew, Al-Chalabi, Ammar, Bis, Joshua C, Ruiz, Agustin, Boada, Mercè, Seshadri, Sudha, Beiser, Alexa, Rice, Kenneth, Van Der Lee, Sven J, De Jager, Philip L, Geschwind, Daniel H, Riemenschneider, Matthias, Riedel-Heller, Steffi, Rotter, Jerome I, Ransmayr, Gerhard, Hyman, Bradley T, Cruchaga, Carlos, Alegret, Montserrat, Winsvold, Bendik, Palta, Priit, Farh, Kai-How, Cuenca-Leon, Ester, Furlotte, Nicholas, Kurth, Tobias, Ligthart, Lannie, Terwindt, Gisela M, Freilinger, Tobias, Ran, Caroline, Gordon, Scott D, Borck, Guntram, Adams, Hieab HH, Lehtimäki, Terho, Wedenoja, Juho, Buring, Julie E, Schürks, Markus, Hrafnsdottir, Maria, Hottenga, Jouke-Jan, Penninx, Brenda, Artto, Ville, Kaunisto, Mari, Vepsäläinen, Salli, Martin, Nicholas G, Montgomery, Grant W, Kurki, Mitja I, Hämäläinen, Eija, Huang, Hailiang, Huang, Jie, Sandor, Cynthia, Webber, Caleb, Muller-Myhsok, Bertram, Schreiber, Stefan, Salomaa, Veikko, Loehrer, Elizabeth, Göbel, Hartmut, Macaya, Alfons, Pozo-Rosich, Patricia, Hansen, Thomas, Werge, Thomas, Kaprio, Jaakko, Metspalu, Andres, Kubisch, Christian, Ferrari, Michel D, Belin, Andrea C, Van Den Maagdenberg, Arn MJM, Zwart, John-Anker, Boomsma, Dorret, Eriksson, Nicholas, Olesen, Jes, Chasman, Daniel I, Nyholt, Dale R, Avbersek, Andreja, Baum, Larry, Berkovic, Samuel, Bradfield, Jonathan, Buono, Russell J, Catarino, Claudia B, Cossette, Patrick, De Jonghe, Peter, Depondt, Chantal, Dlugos, Dennis, Ferraro, Thomas N, French, Jacqueline, Hjalgrim, Helle, Jamnadas-Khoda, Jennifer, Kälviäinen, Reetta, Kunz, Wolfram S, Lerche, Holger, Leu, Costin, Lindhout, Dick, Lo, Warren, Lowenstein, Daniel, McCormack, Mark, Møller, Rikke S, Molloy, Anne, Ng, Ping-Wing, Oliver, Karen, Privitera, Michael, Radtke, Rodney, Ruppert, Ann-Kathrin, Sander, Thomas, Schachter, Steven, Schankin, Christoph, Scheffer, Ingrid, Schoch, Susanne, Sisodiya, Sanjay M, Smith, Philip, Sperling, Michael, Striano, Pasquale, Surges, Rainer, Thomas, G Neil, Visscher, Frank, Whelan, Christopher D, Zara, Federico, Heinzen, Erin L, Marson, Anthony, Becker, Felicitas, Stroink, Hans, Zimprich, Fritz, Gasser, Thomas, Gibbs, Raphael, Heutink, Peter, Martinez, Maria, Morris, Huw R, Sharma, Manu, Ryten, Mina, Mok, Kin Y, Pulit, Sara, Bevan, Steve, Holliday, Elizabeth, Attia, John, Battey, Thomas, Boncoraglio, Giorgio, Thijs, Vincent, Chen, Wei-Min, Mitchell, Braxton, Rothwell, Peter, Sharma, Pankaj, Sudlow, Cathie, Vicente, Astrid, Markus, Hugh, Kourkoulis, Christina, Pera, Joana, Raffeld, Miriam, Silliman, Scott, Boraska Perica, Vesna, Thornton, Laura M, Huckins, Laura M, William Rayner, N, Lewis, Cathryn M, Gratacos, Monica, Rybakowski, Filip, Keski-Rahkonen, Anna, Raevuori, Anu, Hudson, James I, Reichborn-Kjennerud, Ted, Monteleone, Palmiero, Karwautz, Andreas, Mannik, Katrin, Baker, Jessica H, O'Toole, Julie K, Trace, Sara E, Davis, Oliver SP, Helder, Sietske G, Ehrlich, Stefan, Herpertz-Dahlmann, Beate, Danner, Unna N, Van Elburg, Annemarie A, Clementi, Maurizio, Forzan, Monica, Docampo, Elisa, Lissowska, Jolanta, Hauser, Joanna, Tortorella, Alfonso, Maj, Mario, Gonidakis, Fragiskos, Tziouvas, Konstantinos, Papezova, Hana, Yilmaz, Zeynep, Wagner, Gudrun, Cohen-Woods, Sarah, Herms, Stefan, Julià, Antonio, Rabionet, Raquel, Dick, Danielle M, Ripatti, Samuli, Andreassen, Ole A, Espeseth, Thomas, Lundervold, Astri J, Steen, Vidar M, Pinto, Dalila, Scherer, Stephen W, Aschauer, Harald, Schosser, Alexandra, Alfredsson, Lars, Padyukov, Leonid, Halmi, Katherine A, Mitchell, James, Strober, Michael, Bergen, Andrew W, Kaye, Walter, Szatkiewicz, Jin Peng, Cormand, Bru, Ramos-Quiroga, Josep Antoni, Sánchez-Mora, Cristina, Ribasés, Marta, Casas, Miguel, Hervas, Amaia, Arranz, Maria Jesús, Haavik, Jan, Zayats, Tetyana, Johansson, Stefan, Williams, Nigel, Dempfle, Astrid, Rothenberger, Aribert, Kuntsi, Jonna, Oades, Robert D, Banaschewski, Tobias, Franke, Barbara, Buitelaar, Jan K, Arias Vasquez, Alejandro, Doyle, Alysa E, Reif, Andreas, Lesch, Klaus-Peter, Freitag, Christine, Rivero, Olga, Palmason, Haukur, Romanos, Marcel, Langley, Kate, Rietschel, Marcella, Witt, Stephanie H, Dalsgaard, Soeren, Børglum, Anders D, Waldman, Irwin, Wilmot, Beth, Molly, Nikolas, Bau, Claiton HD, Crosbie, Jennifer, Schachar, Russell, Loo, Sandra K, McGough, James J, Grevet, Eugenio H, Medland, Sarah E, Robinson, Elise, Weiss, Lauren A, Bacchelli, Elena, Bailey, Anthony, Bal, Vanessa, Battaglia, Agatino, Betancur, Catalina, Bolton, Patrick, Cantor, Rita, Celestino-Soper, Patrícia, Dawson, Geraldine, De Rubeis, Silvia, Duque, Frederico, Green, Andrew, Klauck, Sabine M, Leboyer, Marion, Levitt, Pat, Maestrini, Elena, Mane, Shrikant, De-Luca, Daniel Moreno, Parr, Jeremy, Regan, Regina, Reichenberg, Abraham, Sandin, Sven, Vorstman, Jacob, Wassink, Thomas, Wijsman, Ellen, Cook, Edwin, Santangelo, Susan, Delorme, Richard, Rogé, Bernadette, Magalhaes, Tiago, Arking, Dan, Schulze, Thomas G, Thompson, Robert C, Strohmaier, Jana, Matthews, Keith, Melle, Ingrid, Morris, Derek, Blackwood, Douglas, McIntosh, Andrew, Bergen, Sarah E, Schalling, Martin, Jamain, Stéphane, Maaser, Anna, Fischer, Sascha B, Reinbold, Céline S, Fullerton, Janice M, Guzman-Parra, José, Mayoral, Fermin, Schofield, Peter R, Cichon, Sven, Mühleisen, Thomas W, Degenhardt, Franziska, Schumacher, Johannes, Bauer, Michael, Mitchell, Philip B, Gershon, Elliot S, Rice, John, Potash, James B, Zandi, Peter P, Craddock, Nick, Ferrier, I Nicol, Alda, Martin, Rouleau, Guy A, Turecki, Gustavo, Ophoff, Roel, Pato, Carlos, Anjorin, Adebayo, Stahl, Eli, Leber, Markus, Czerski, Piotr M, Cruceanu, Cristiana, Jones, Ian R, Posthuma, Danielle, Andlauer, Till FM, Forstner, Andreas J, Streit, Fabian, Baune, Bernhard T, Air, Tracy, Sinnamon, Grant, Wray, Naomi R, MacIntyre, Donald J, Porteous, David, Homuth, Georg, Rivera, Margarita, Grove, Jakob, Middeldorp, Christel M, Hickie, Ian, Pergadia, Michele, Mehta, Divya, Smit, Johannes H, Jansen, Rick, De Geus, Eco, Dunn, Erin, Li, Qingqin S, Nauck, Matthias, Schoevers, Robert A, Beekman, Aartjan Tf, Knowles, James A, Viktorin, Alexander, Arnold, Paul, Barr, Cathy L, Bedoya-Berrio, Gabriel, Bienvenu, O Joseph, Brentani, Helena, Burton, Christie, Camarena, Beatriz, Cappi, Carolina, Cath, Danielle, Cavallini, Maria, Cusi, Daniele, Darrow, Sabrina, Denys, Damiaan, Derks, Eske M, Dietrich, Andrea, Fernandez, Thomas, Figee, Martijn, Freimer, Nelson, Gerber, Gloria, Grados, Marco, Greenberg, Erica, Hanna, Gregory L, Hartmann, Andreas, Hirschtritt, Matthew E, Hoekstra, Pieter J, Huang, Alden, Huyser, Chaim, Illmann, Cornelia, Jenike, Michael, Kuperman, Samuel, Leventhal, Bennett, Lochner, Christine, Lyon, Gholson J, Macciardi, Fabio, Madruga-Garrido, Marcos, Malaty, Irene A, Maras, Athanasios, McGrath, Lauren, Miguel, Eurípedes C, Mir, Pablo, Nestadt, Gerald, Nicolini, Humberto, Okun, Michael S, Pakstis, Andrew, Paschou, Peristera, Piacentini, John, Pittenger, Christopher, Plessen, Kerstin, Ramensky, Vasily, Ramos, Eliana M, Reus, Victor, Richter, Margaret A, Riddle, Mark A, Robertson, Mary M, Roessner, Veit, Rosário, Maria, Samuels, Jack F, Sandor, Paul, Stein, Dan J, Tsetsos, Fotis, Van Nieuwerburgh, Filip, Weatherall, Sarah, Wendland, Jens R, Wolanczyk, Tomasz, Worbe, Yulia, Zai, Gwyneth, Goes, Fernando S, McLaughlin, Nicole, Nestadt, Paul S, Grabe, Hans-Jorgen, Depienne, Christel, Konkashbaev, Anuar, Lanzagorta, Nuria, Valencia-Duarte, Ana, Bramon, Elvira, Buccola, Nancy, Cahn, Wiepke, Cairns, Murray, Chong, Siow A, Cohen, David, Crespo-Facorro, Benedicto, Crowley, James, Davidson, Michael, DeLisi, Lynn, Dinan, Timothy, Donohoe, Gary, Drapeau, Elodie, Duan, Jubao, Haan, Lieuwe, Hougaard, David, Karachanak-Yankova, Sena, Khrunin, Andrey, Klovins, Janis, Kučinskas, Vaidutis, Lee Chee Keong, Jimmy, Limborska, Svetlana, Loughland, Carmel, Lönnqvist, Jouko, Maher, Brion, Mattheisen, Manuel, McDonald, Colm, Murphy, Kieran C, Nenadic, Igor, Van Os, Jim, Pantelis, Christos, Pato, Michele, Petryshen, Tracey, Quested, Digby, Roussos, Panos, Sanders, Alan R, Schall, Ulrich, Schwab, Sibylle G, Sim, Kang, So, Hon-Cheong, Stögmann, Elisabeth, Subramaniam, Mythily, Toncheva, Draga, Waddington, John, Walters, James, Weiser, Mark, Cheng, Wei, Cloninger, Robert, Curtis, David, Gejman, Pablo V, Henskens, Frans, Mattingsdal, Morten, Oh, Sang-Yun, Scott, Rodney, Webb, Bradley, Breen, Gerome, Churchhouse, Claire, Bulik, Cynthia M, Daly, Mark, Dichgans, Martin, Faraone, Stephen V, Guerreiro, Rita, Holmans, Peter, Kendler, Kenneth S, Koeleman, Bobby, Mathews, Carol A, Price, Alkes, Scharf, Jeremiah, Sklar, Pamela, Williams, Julie, Wood, Nicholas W, Cotsapas, Chris, Palotie, Aarno, Smoller, Jordan W, Sullivan, Patrick, Rosand, Jonathan, Corvin, Aiden, Neale, Benjamin M, Schott, Jonathan M, Anney, Richard, Elia, Josephine, Grigoroiu-Serbanescu, Maria, Edenberg, Howard J, Murray, Robin, Massachusetts General Hospital [Boston], Broad Institute of MIT and Harvard (BROAD INSTITUTE), Harvard Medical School [Boston] (HMS)-Massachusetts Institute of Technology (MIT)-Massachusetts General Hospital [Boston], UK Dementia Research Institute (UK DRI), University College of London [London] (UCL), School of Psychology [Cardiff University], Cardiff University, Institute for Stroke and Dementia Research (ISD), Klinikum der Universität [München]-Ludwig Maximilian University [Munich] (LMU), New Jersey Institute of Technology [Newark] (NJIT), Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 (RID-AGE), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), RIKEN Center for Integrative Medical Sciences [Yokohama] (RIKEN IMS), RIKEN - Institute of Physical and Chemical Research [Japon] (RIKEN), Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Laboratoire de Biotechnologie et Microbiologie Appliquée (LBMA), Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de neurologie [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU), Institut de Biologie François JACOB (JACOB), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Gériatrie générale et aigüe [Paris], AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Columbia University [New York], Dpt of Neuroscience [New York], Icahn School of Medicine at Mount Sinai [New York] (MSSM), University of Pittsburgh (PITT), Pennsylvania Commonwealth System of Higher Education (PCSHE), University of Washington [Seattle], Tanz Center Research in Neurodegenerative Diseases [Toronto], University of Toronto, Children’s Hospital of Philadelphia (CHOP ), University of Kentucky (UK), School of medicine, Duke University [Durham], College of medicine, Brigham Young University (BYU), Oregon Health and Science University [Portland] (OHSU), Cleveland Clinic, Department of Neurology, Emory University [Atlanta, GA], Medical School, University of Michigan [Ann Arbor], University of Michigan System-University of Michigan System, Health sciences center, The University of New Mexico [Albuquerque], Institute for Memory Impairments and Neurological Disorders [Irvine], University of California [Irvine] (UC Irvine), University of California (UC)-University of California (UC), Indiana University - Purdue University Indianapolis (IUPUI), Indiana University System, Keck School of Medicine [Los Angeles], University of Southern California (USC), University of South Florida [Tampa] (USF), University of Utah School of Medicine [Salt Lake City], Boston University School of Medicine (BUSM), Boston University [Boston] (BU), Perelman School of Medicine, University of Pennsylvania, Dublin City University [Dublin] (DCU), Functional Genomics Center Zurich, Universität Zürich [Zürich] = University of Zurich (UZH)- Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Cambridge Institute for Medical Research (CIMR), University of Cambridge [UK] (CAM), Aristotle University of Thessaloniki, Maurice Wohl Clinical Neuroscience Institut, King‘s College London, Dementia Research Centre [London] (DRC), Groupe de recherche clinique Alzheimer Precision Medicine (GRC 21 - APM), Sorbonne Université (SU), MRC Centre for Neuropsychiatric Genetics and Genomics, Medical Research Council-Cardiff University, MRC Prion Unit [London], Queen's University [Belfast] (QUB), School of Life Sciences, University of Nottingham, UK (UON), Rheinische Friedrich-Wilhelms-Universität Bonn, Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), QIMR Berghofer Medical Research Institute, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), School of Medicine [Dublin], Trinity College Dublin, Department of Medicine, University of Texas Health Science Center, The University of Texas Health Science Center at Houston (UTHealth), School of Public Health [Boston], Erasmus University Medical Center [Rotterdam] (Erasmus MC), Columbia University Medical Center (CUMC), David Geffen School of Medicine [Los Angeles], University of California [Los Angeles] (UCLA), Saarland University [Saarbrücken], Universität Leipzig, School of Medicine [Los Angeles], Johannes Kepler Universität Linz - Johannes Kepler University Linz [Autriche] (JKU), Department of Neurology [Boston], Harvard Medical School [Boston] (HMS)-Massachusetts General Hospital [Boston], School of Medecine, Washington University in Saint Louis (WUSTL), Oslo University Hospital [Oslo], Institute for Molecular Medicine Finland [Helsinki] (FIMM), Helsinki Institute of Life Science (HiLIFE), Helsingin yliopisto = Helsingfors universitet = University of Helsinki-Helsingin yliopisto = Helsingfors universitet = University of Helsinki, 23andMe Inc., Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Department of Biological Psychology [Amsterdam], Vrije Universiteit Amsterdam [Amsterdam] (VU), Leiden University Medical Center (LUMC), Universiteit Leiden, University-Hospital Munich-Großhadern [München], Karolinska Institutet [Stockholm], Universität Ulm - Ulm University [Ulm, Allemagne], Faculty of Medicine and Life Sciences [Tampere], University of Tampere [Finland], Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Brigham & Women’s Hospital [Boston] (BWH), Harvard Medical School [Boston] (HMS), Landspitali National University Hospital of Iceland, VU University Medical Center [Amsterdam], Boston VA Research Institute (BVARI), Department of Physiology, Anatomy and Genetics [Oxford], University of Oxford, Max Planck Institute of Psychiatry, Max-Planck-Gesellschaft, Christian-Albrechts-Universität zu Kiel (CAU), Institute of Clinical Molecular Biology, Kiel University, National Institute for Health and Welfare [Helsinki], Harvard T.H. Chan School of Public Health, Universitat Autònoma de Barcelona (UAB), Vall d'Hebron University Hospital [Barcelona], University of Tartu, Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg] (UKE), Center for Human and Clinical Genetics, Universiteit Leiden-Universiteit Leiden, University of Copenhagen = Københavns Universitet (UCPH), Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology [Brisbane] (QUT), Discipline of Psychiatry [Dublin], Trinity College Dublin-Trinity College Dublin, Institute of Neurology [London], The University of Hong Kong (HKU), University of Melbourne, Cooper Medical School of Rowan University [Camden] (CMSRU), Centre Hospitalier de l'Université de Montréal (CHUM), Université de Montréal (UdeM), University of Antwerp (UA), Hôpital Erasme [Bruxelles] (ULB), Faculté de Médecine [Bruxelles] (ULB), Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB), New York University School of Medicine (NYU), New York University School of Medicine, NYU System (NYU)-NYU System (NYU), University of Eastern Finland, Universitätsklinikum Bonn (UKB), Hertie Institute for Clinical Brain Research [Tubingen], University of Tübingen, NIHR Biomedical Research Centre [London], Guy's and St Thomas' NHS Foundation Trust-King‘s College London, University Medical Center [Utrecht], Ohio State University [Columbus] (OSU), University of California [San Francisco] (UC San Francisco), University of California (UC), Royal College of Surgeons in Ireland (RCSI), University of Southern Denmark (SDU), United Christian Hospital [Hong Kong] (UCH), University of Cincinnati (UC), University of Cologne, Inselspital Bern, University of Wales, Jefferson University Hospitals, University of Liverpool, Medizinische Universität Wien = Medical University of Vienna, National Institutes of Health [Bethesda] (NIH), German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Institut de Recherche en Santé Digestive (IRSD ), Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Lincoln, University of Newcastle [Callaghan, Australia] (UoN), Fondazione IRCCS Istituto Neurologico 'Carlo Besta', University of Virginia, University of Maryland [Baltimore County] (UMBC), University of Maryland System, Royal Holloway [University of London] (RHUL), University of Edinburgh, Universidade de Lisboa = University of Lisbon (ULISBOA), Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), University of Split, University of North Carolina [Chapel Hill] (UNC), University of North Carolina System (UNC), Center for Genomic Regulation (CRG-UPF), CIBER de Epidemiología y Salud Pública (CIBERESP), McLean Hospital [Belmont, Ma.], Norwegian Institute of Public Health [Oslo] (NIPH), Università degli Studi di Salerno = University of Salerno (UNISA), University of Bristol [Bristol], Technische Universität Dresden = Dresden University of Technology (TU Dresden), Rheinisch-Westfälische Technische Hochschule Aachen University (RWTH), Utrecht University [Utrecht], Azienda Ospedaliera di Padova, Université de Liège, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology (MCMCC), Università degli Studi di Perugia = University of Perugia (UNIPG), Università degli studi della Campania 'Luigi Vanvitelli' = University of the Study of Campania Luigi Vanvitelli, National and Kapodistrian University of Athens (NKUA), Charles University [Prague] (CU), SURFACES, Institut de recherches sur la catalyse et l'environnement de Lyon (IRCELYON), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Flinders University [Adelaide, Australia], Virginia Commonwealth University (VCU), University of Oslo (UiO), University of Bergen (UiB), Weill Medical College of Cornell University [New York], University of North Dakota [Grand Forks] (UND), Oregon Research Institute (ORI), University of California [San Diego] (UC San Diego), Universitat de Barcelona (UB), Centro de Investigación Biomédica en Red Salud Mental [Madrid] (CIBER-SAM), Hospital Universitario Mutua de Terrassa, School of Computer Science and Communication [Stockholm], Royal Institute of Technology [Stockholm] (KTH ), Jefferson (Philadelphia University + Thomas Jefferson University), University Medical Center Göttingen (UMG), Universität Heidelberg [Heidelberg] = Heidelberg University, Radboud University Medical Center [Nijmegen], Universitätsklinikum Frankfurt, Maastricht University [Maastricht], Institute of Psychological Medicine and Clinical Neurosciences, Aarhus University [Aarhus], University of Iowa [Iowa City], Universidade Federal do Rio Grande do Sul [Porto Alegre] (UFRGS), The Hospital for sick children [Toronto] (SickKids), Hospital de Clínicas de Porto Alegre (HCPA), Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), University of British Columbia (UBC), IRCCS Fondazione Stella Maris [Pisa], Institut de Biologie Paris Seine (IBPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Neuroscience Paris Seine (NPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Paris Seine (IBPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Universidade de Coimbra [Coimbra], Academic Centre on Rare Diseases (ACoRD), University College Dublin [Dublin] (UCD), Our Lady's Children's Hospital Crumlin (OLCHC), German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Children’s Hospital Los Angeles [Los Angeles], Yale University [New Haven], Brown University, Institute of Neuroscience [Newcastle] (ION), Newcastle University [Newcastle], Department of Medical Epidemiology and Biostatistics (MEB), Division of Medical Genetics [Seattle], University of Illinois [Chicago] (UIC), University of Illinois System, Maine Medical Center Research Institute (MMCRI), Génétique humaine et fonctions cognitives - Human Genetics and Cognitive Functions (GHFC (UMR_3571 / U-Pasteur_1)), Institut Pasteur [Paris] (IP)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Centre d’Etudes et de Recherches en Psychopathologie et Psychologie de la Santé (CERPPS), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-Toulouse Mind & Brain Institut (TMBI), Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT), Johns Hopkins University School of Medicine [Baltimore], Ludwig Maximilian University [Munich] (LMU), University of Michigan System, Department of Genetic Epidemiology in Psychiatry [Mannhein], Universität Heidelberg [Heidelberg] = Heidelberg University-Central Institute of Mental Health Mannheim, University of Dundee, National University of Ireland [Galway] (NUI Galway), University Hospital Basel [Basel], Neuroscience Research Australia (NeuRA), Forschungszentrum Jülich GmbH | Centre de recherche de Juliers, Helmholtz-Gemeinschaft = Helmholtz Association, UNSW Faculty of Medicine [Sydney], University of New South Wales [Sydney] (UNSW), University of Chicago, Johns Hopkins University (JHU), Johns Hopkins Bloomberg School of Public Health [Baltimore], Dalhousie University [Halifax], Montreal Neurological Institute and Hospital, McGill University = Université McGill [Montréal, Canada], State University of New York (SUNY), University Hospital of Cologne [Cologne], University of Adelaide, James Cook University (JCU), Institute for Molecular Bioscience, University of Queensland [Brisbane], Greifswald University Hospital, The University of Sydney, University Medical Center Groningen [Groningen] (UMCG), University of Calgary, University Health Network, Universidad de Antioquia = University of Antioquia [Medellín, Colombia], Universidade de São Paulo = University of São Paulo (USP), Ospedale San Raffaele, University of Amsterdam [Amsterdam] (UvA), University of Groningen [Groningen], Yale School of Medicine [New Haven, Connecticut] (YSM), Academic Medical Center - Academisch Medisch Centrum [Amsterdam] (AMC), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), University of Cape Town, Cold Spring Harbor Laboratory (CSHL), Universidad de Sevilla / University of Sevilla, University of Florida [Gainesville] (UF), University of Denver, Purdue University [West Lafayette], Centre Hospitalier Universitaire Vaudois [Lausanne] (CHUV), Moscow Institute of Physics and Technology [Moscow] (MIPT), Sunnybrook Health Sciences Centre, Federal Institute of São Paulo (IFSP), Democritus University of Thrace (DUTH), Universiteit Gent = Ghent University (UGENT), Medical University of Warsaw - Poland, Sorbonne Université - Faculté de Médecine - Département d'Enseignement et de Recherche en Médecine Générale, Universitätsklinikum Essen [Universität Duisburg-Essen] (Uniklinik Essen), Vanderbilt University Medical Center [Nashville], Vanderbilt University [Nashville], Institute of Mental Health [Singapore], Universidad de Cantabria [Santander], Tel Aviv University (TAU), University College Cork (UCC), University of Rochester [USA], Statens Serum Institut [Copenhagen], Софийски университет = Sofia University, Russian Academy of Sciences [Moscow] (RAS), Latvian Biomedical Research and Study Centre [Rīga], Vilnius University [Vilnius], Nanyang Technological University [Singapour], Department of Life Sciences, Imperial College London, Jena University Hospital [Jena], Oxford University Hospitals NHS Trust, Schizophrenia Research Institute [Sydney], Faculty of Science, Medicine and Health [Wollongong], University of Wollongong [Australia], City University of Hong Kong [Hong Kong] (CUHK), Lawrence Berkeley National Laboratory [Berkeley] (LBNL), This work was supported by grants 1R01MH10764901 and 5U01MH09443203 from the National Institute of Mental Health, as well as the Orion Farmos Research Foundation (V.A.) and the Fannie and John Hertz Foundation (H.K.F.). Consortium specific funding is detailed in the supplementary materials ('Study-specific acknowledgments')., Brainstorm Consortium, University of Kentucky, University of California [Irvine] (UCI), University of California-University of California, University of Pennsylvania [Philadelphia], Alzheimer Precision Medicine [CHU Pitié-Salpétriêre] (GRC 21 AMP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Universität Leipzig [Leipzig], Johannes Kepler University Linz [Linz] (JKU), University of Helsinki-University of Helsinki, University of Helsinki, University of Oxford [Oxford], University of Copenhagen = Københavns Universitet (KU), University of California [San Francisco] (UCSF), University of California, Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Newcastle [Australia] (UoN), University of Virginia [Charlottesville], Universidade de Lisboa (ULISBOA), Università degli Studi di Salerno (UNISA), Rheinisch-Westfälische Technische Hochschule Aachen (RWTH), Università degli Studi di Perugia (UNIPG), Università degli studi della Campania 'Luigi Vanvitelli', Universität Heidelberg [Heidelberg], Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris]-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Universität Heidelberg [Heidelberg]-Central Institute of Mental Health Mannheim, VU University Amsterdam, Universidade de São Paulo (USP), Yale University School of Medicine, Universidad de Sevilla, Universiteit Gent = Ghent University [Belgium] (UGENT), Service de Psychiatrie de l'Enfant et de l'Adolescent [CHU Pitié-Salpêtrière] (SPEA), Tel Aviv University [Tel Aviv], University of Sofia, Anttila, Verneri, Bulik-Sullivan, Brendan, Finucane, Hilary K., Walters, Raymond K., Bras, Jose, Duncan, Laramie, Escott-Price, Valentina, Falcone, Guido J., Gormley, Padhraig, Malik, Rainer, Patsopoulos, Nikolaos A., Ripke, Stephan, Wei, Zhi, Yu, Dongmei, Lee, Phil H., Turley, Patrick, Grenier-Boley, Benjamin, Chouraki, Vincent, Kamatani, Yoichiro, Berr, Claudine, Letenneur, Luc, Hannequin, Didier, Amouyel, Philippe, Boland, Anne, Deleuze, Jean-Françoi, Duron, Emmanuelle, Vardarajan, Badri N., Reitz, Christiane, Goate, Alison M., Huentelman, Matthew J., Ilyas Kamboh, M., Larson, Eric B., Rogaeva, Ekaterina, George-Hyslop, Peter St, Hakonarson, Hakon, Kukull, Walter A., Farrer, Lindsay A., Barnes, Lisa L., Beach, Thomas G., Yesim Demirci, F., Head, Elizabeth, Hulette, Christine M., Jicha, Gregory A., Kauwe, John S.K., Kaye, Jeffrey A., Leverenz, James B., Levey, Allan I., Lieberman, Andrew P., Pankratz, Vernon S., Poon, Wayne W., Quinn, Joseph F., Saykin, Andrew J., Schneider, Lon S., Smith, Amanda G., Sonnen, Joshua A., Stern, Robert A., Van Deerlin, Vivianna M., Van Eldik, Linda J., Harold, Denise, Russo, Giancarlo, Rubinsztein, David C., Bayer, Anthony, Tsolaki, Magda, Proitsi, Petra, Fox, Nick C., Hampel, Harald, Owen, Michael J., Mead, Simon, Passmore, Peter, Morgan, Kevin, Nöthen, Markus M., Rossor, Martin, Lupton, Michelle K., Hoffmann, Per, Kornhuber, Johanne, Lawlor, Brian, McQuillin, Andrew, Al-Chalabi, Ammar, Bis, Joshua C., Ruiz, Agustin, Boada, Mercè, Seshadri, Sudha, Beiser, Alexa, Rice, Kenneth, Van Der Lee, Sven J., De Jager, Philip L., Geschwind, Daniel H., Riemenschneider, Matthia, Riedel-Heller, Steffi, Rotter, Jerome I., Ransmayr, Gerhard, Hyman, Bradley T., Cruchaga, Carlo, Alegret, Montserrat, Winsvold, Bendik, Palta, Priit, Farh, Kai-How, Cuenca-Leon, Ester, Furlotte, Nichola, Kurth, Tobia, Ligthart, Lannie, Terwindt, Gisela M., Freilinger, Tobia, Ran, Caroline, Gordon, Scott D., Borck, Guntram, Adams, Hieab H.H., Lehtimäki, Terho, Wedenoja, Juho, Buring, Julie E., Schürks, Marku, Hrafnsdottir, Maria, Hottenga, Jouke-Jan, Penninx, Brenda, Artto, Ville, Kaunisto, Mari, Vepsäläinen, Salli, Martin, Nicholas G., Montgomery, Grant W., Kurki, Mitja I., Hämäläinen, Eija, Huang, Hailiang, Huang, Jie, Sandor, Cynthia, Webber, Caleb, Muller-Myhsok, Bertram, Schreiber, Stefan, Salomaa, Veikko, Loehrer, Elizabeth, Göbel, Hartmut, Macaya, Alfon, Pozo-Rosich, Patricia, Hansen, Thoma, Werge, Thoma, Kaprio, Jaakko, Metspalu, Andre, Kubisch, Christian, Ferrari, Michel D., Belin, Andrea C., Van Den Maagdenberg, Arn M. J. M., Zwart, John-Anker, Boomsma, Dorret, Eriksson, Nichola, Olesen, Je, Chasman, Daniel I., Nyholt, Dale R., Avbersek, Andreja, Baum, Larry, Berkovic, Samuel, Bradfield, Jonathan, Buono, Russell, Catarino, Claudia B., Cossette, Patrick, De Jonghe, Peter, Depondt, Chantal, Dlugos, Denni, Ferraro, Thomas N., French, Jacqueline, Hjalgrim, Helle, Jamnadas-Khoda, Jennifer, Kälviäinen, Reetta, Kunz, Wolfram S., Lerche, Holger, Leu, Costin, Lindhout, Dick, Lo, Warren, Lowenstein, Daniel, McCormack, Mark, Møller, Rikke S., Molloy, Anne, Ng, Ping-Wing, Oliver, Karen, Privitera, Michael, Radtke, Rodney, Ruppert, Ann-Kathrin, Sander, Thoma, Schachter, Steven, Schankin, Christoph, Scheffer, Ingrid, Schoch, Susanne, Sisodiya, Sanjay M., Smith, Philip, Sperling, Michael, Striano, Pasquale, Surges, Rainer, Neil Thomas, G., Visscher, Frank, Whelan, Christopher D., Zara, Federico, Heinzen, Erin L., Marson, Anthony, Becker, Felicita, Stroink, Han, Zimprich, Fritz, Gasser, Thoma, Gibbs, Raphael, Heutink, Peter, Martinez, Maria, Morris, Huw R., Sharma, Manu, Ryten, Mina, Mok, Kin Y., Pulit, Sara, Bevan, Steve, Holliday, Elizabeth, Attia, John, Battey, Thoma, Boncoraglio, Giorgio, Thijs, Vincent, Chen, Wei-Min, Mitchell, Braxton, Rothwell, Peter, Sharma, Pankaj, Sudlow, Cathie, Vicente, Astrid, Markus, Hugh, Kourkoulis, Christina, Pera, Joana, Raffeld, Miriam, Silliman, Scott, Perica, Vesna Boraska, Thornton, Laura M., Huckins, Laura M., William Rayner, N., Lewis, Cathryn M., Gratacos, Monica, Rybakowski, Filip, Keski-Rahkonen, Anna, Raevuori, Anu, Hudson, James I., Reichborn-Kjennerud, Ted, Monteleone, Palmiero, Karwautz, Andrea, Mannik, Katrin, Baker, Jessica H., O'Toole, Julie K., Trace, Sara E., Davis, Oliver S. P., Helder, Sietske G., Ehrlich, Stefan, Herpertz-Dahlmann, Beate, Danner, Unna N., Van Elburg, Annemarie A., Clementi, Maurizio, Forzan, Monica, Docampo, Elisa, Lissowska, Jolanta, Hauser, Joanna, Tortorella, Alfonso, Maj, Mario, Gonidakis, Fragisko, Tziouvas, Konstantino, Papezova, Hana, Yilmaz, Zeynep, Wagner, Gudrun, Cohen-Woods, Sarah, Herms, Stefan, Julia, Antonio, Rabionet, Raquel, Dick, Danielle M., Ripatti, Samuli, Andreassen, Ole A., Espeseth, Thoma, Lundervold, Astri J., Steen, Vidar M., Pinto, Dalila, Scherer, Stephen W., Aschauer, Harald, Schosser, Alexandra, Alfredsson, Lar, Padyukov, Leonid, Halmi, Katherine A., Mitchell, Jame, Strober, Michael, Bergen, Andrew W., Kaye, Walter, Szatkiewicz, Jin Peng, Cormand, Bru, Ramos-Quiroga, Josep Antoni, Sánchez-Mora, Cristina, Ribasés, Marta, Casas, Miguel, Hervas, Amaia, Arranz, Maria Jesú, Haavik, Jan, Zayats, Tetyana, Johansson, Stefan, Williams, Nigel, Dempfle, Astrid, Rothenberger, Aribert, Kuntsi, Jonna, Oades, Robert D., Banaschewski, Tobia, Franke, Barbara, Buitelaar, Jan K., Vasquez, Alejandro Aria, Doyle, Alysa E., Reif, Andrea, Lesch, Klaus-Peter, Freitag, Christine, Rivero, Olga, Palmason, Haukur, Romanos, Marcel, Langley, Kate, Rietschel, Marcella, Witt, Stephanie H., Dalsgaard, Soeren, Børglum, Anders D., Waldman, Irwin, Wilmot, Beth, Molly, Nikola, Bau, Claiton H.D., Crosbie, Jennifer, Schachar, Russell, Loo, Sandra K., McGough, James J., Grevet, Eugenio H., Medland, Sarah E., Robinson, Elise, Weiss, Lauren A., Bacchelli, Elena, Bailey, Anthony, Bal, Vanessa, Battaglia, Agatino, Betancur, Catalina, Bolton, Patrick, Cantor, Rita, Celestino-Soper, Patrícia, Dawson, Geraldine, De Rubeis, Silvia, Duque, Frederico, Green, Andrew, Klauck, Sabine M., Leboyer, Marion, Levitt, Pat, Maestrini, Elena, Mane, Shrikant, Moreno-De-Luca, Daniel, Parr, Jeremy, Regan, Regina, Reichenberg, Abraham, Sandin, Sven, Vorstman, Jacob, Wassink, Thoma, Wijsman, Ellen, Cook, Edwin, Santangelo, Susan, Delorme, Richard, Roge, Bernadette, Magalhaes, Tiago, Arking, Dan, Schulze, Thomas G., Thompson, Robert C., Strohmaier, Jana, Matthews, Keith, Melle, Ingrid, Morris, Derek, Blackwood, Dougla, McIntosh, Andrew, Bergen, Sarah E., Schalling, Martin, Jamain, Stéphane, Maaser, Anna, Fischer, Sascha B., Reinbold, Céline S., Fullerton, Janice M., Guzman-Parra, José, Mayoral, Fermin, Schofield, Peter R., Cichon, Sven, Mühleisen, Thomas W., Degenhardt, Franziska, Schumacher, Johanne, Bauer, Michael, Mitchell, Philip B., Gershon, Elliot S., Rice, John, Potash, James B., Zandi, Peter P., Craddock, Nick, Nicol Ferrier, I., Alda, Martin, Rouleau, Guy A., Turecki, Gustavo, Ophoff, Roel, Pato, Carlo, Anjorin, Adebayo, Stahl, Eli, Leber, Marku, Czerski, Piotr M., Cruceanu, Cristiana, Jones, Ian R., Posthuma, Danielle, Andlauer, Till F.M., Forstner, Andreas J., Streit, Fabian, Baune, Bernhard T., Air, Tracy, Sinnamon, Grant, Wray, Naomi R., MacIntyre, Donald J., Porteous, David, Homuth, Georg, Rivera, Margarita, Grove, Jakob, Middeldorp, Christel M., Hickie, Ian, Pergadia, Michele, Mehta, Divya, Smit, Johannes H., Jansen, Rick, De Geus, Eco, Dunn, Erin, Li, Qingqin S., Nauck, Matthia, Schoevers, Robert A., Beekman, Aartjan TF, Knowles, James A., Viktorin, Alexander, Arnold, Paul, Barr, Cathy L., Bedoya-Berrio, Gabriel, Joseph Bienvenu, O., Brentani, Helena, Burton, Christie, Camarena, Beatriz, Cappi, Carolina, Cath, Danielle, Cavallini, Maria, Cusi, Daniele, Darrow, Sabrina, Denys, Damiaan, Derks, Eske M., Dietrich, Andrea, Fernandez, Thoma, Figee, Martijn, Freimer, Nelson, Gerber, Gloria, Grados, Marco, Greenberg, Erica, Hanna, Gregory L., Hartmann, Andrea, Hirschtritt, Matthew E., Hoekstra, Pieter J., Huang, Alden, Huyser, Chaim, Illmann, Cornelia, Jenike, Michael, Kuperman, Samuel, Leventhal, Bennett, Lochner, Christine, Lyon, Gholson J., Macciardi, Fabio, Madruga-Garrido, Marco, Malaty, Irene A., Maras, Athanasio, McGrath, Lauren, Miguel, Eurípedes C., Mir, Pablo, Nestadt, Gerald, Nicolini, Humberto, Okun, Michael S., Pakstis, Andrew, Paschou, Peristera, Piacentini, John, Pittenger, Christopher, Plessen, Kerstin, Ramensky, Vasily, Ramos, Eliana M., Reus, Victor, Richter, Margaret A., Riddle, Mark A., Robertson, Mary M., Roessner, Veit, Rosário, Maria, Samuels, Jack F., Sandor, Paul, Stein, Dan J., Tsetsos, Foti, Van Nieuwerburgh, Filip, Weatherall, Sarah, Wendland, Jens R., Wolanczyk, Tomasz, Worbe, Yulia, Zai, Gwyneth, Goes, Fernando S., McLaughlin, Nicole, Nestadt, Paul S., Grabe, Hans-Jorgen, Depienne, Christel, Konkashbaev, Anuar, Lanzagorta, Nuria, Valencia-Duarte, Ana, Bramon, Elvira, Buccola, Nancy, Cahn, Wiepke, Cairns, Murray, Chong, Siow A., Cohen, David, Crespo-Facorro, Benedicto, Crowley, Jame, Davidson, Michael, DeLisi, Lynn, Dinan, Timothy, Donohoe, Gary, Drapeau, Elodie, Duan, Jubao, Haan, Lieuwe, Hougaard, David, Karachanak-Yankova, Sena, Khrunin, Andrey, Klovins, Jani, Kučinskas, Vaiduti, Keong, Jimmy Lee Chee, Limborska, Svetlana, Loughland, Carmel, Lönnqvist, Jouko, Maher, Brion, Mattheisen, Manuel, McDonald, Colm, Murphy, Kieran C., Nenadic, Igor, Van Os, Jim, Pantelis, Christo, Pato, Michele, Petryshen, Tracey, Quested, Digby, Roussos, Pano, Sanders, Alan R., Schall, Ulrich, Schwab, Sibylle G., Sim, Kang, So, Hon-Cheong, Stögmann, Elisabeth, Subramaniam, Mythily, Toncheva, Draga, Waddington, John, Walters, Jame, Weiser, Mark, Cheng, Wei, Cloninger, Robert, Curtis, David, Gejman, Pablo V., Henskens, Fran, Mattingsdal, Morten, Oh, Sang-Yun, Scott, Rodney, Webb, Bradley, Breen, Gerome, Churchhouse, Claire, Bulik, Cynthia M., Daly, Mark, Dichgans, Martin, Faraone, Stephen V., Guerreiro, Rita, Holmans, Peter, Kendler, Kenneth S., Koeleman, Bobby, Mathews, Carol A., Price, Alke, Scharf, Jeremiah, Sklar, Pamela, Williams, Julie, Wood, Nicholas W., Cotsapas, Chri, Palotie, Aarno, Smoller, Jordan W., Sullivan, Patrick, Rosand, Jonathan, Corvin, Aiden, Neale, Benjamin M., Epidemiology, Radiology & Nuclear Medicine, Anttila, V, Bulik-Sullivan, B, Finucane, H, Walters, R, Bras, J, Duncan, L, Escott-Price, V, Falcone, G, Gormley, P, Malik, R, Patsopoulos, N, Ripke, S, Wei, Z, Yu, D, Lee, P, Turley, P, Grenier-Boley, B, Chouraki, V, Kamatani, Y, Berr, C, Letenneur, L, Hannequin, D, Amouyel, P, Boland, A, Deleuze, J, Duron, E, Vardarajan, B, Reitz, C, Goate, A, Huentelman, M, Ilyas Kamboh, M, Larson, E, Rogaeva, E, George-Hyslop, P, Hakonarson, H, Kukull, W, Farrer, L, Barnes, L, Beach, T, Yesim Demirci, F, Head, E, Hulette, C, Jicha, G, Kauwe, J, Kaye, J, Leverenz, J, Levey, A, Lieberman, A, Pankratz, V, Poon, W, Quinn, J, Saykin, A, Schneider, L, Smith, A, Sonnen, J, Stern, R, Van Deerlin, V, Van Eldik, L, Harold, D, Russo, G, Rubinsztein, D, Bayer, A, Tsolaki, M, Proitsi, P, Fox, N, Hampel, H, Owen, M, Mead, S, Passmore, P, Morgan, K, Nöthen, M, Rossor, M, Lupton, M, Hoffmann, P, Kornhuber, J, Lawlor, B, Mcquillin, A, Al-Chalabi, A, Bis, J, Ruiz, A, Boada, M, Seshadri, S, Beiser, A, Rice, K, Van Der Lee, S, De Jager, P, Geschwind, D, Riemenschneider, M, Riedel-Heller, S, Rotter, J, Ransmayr, G, Hyman, B, Cruchaga, C, Alegret, M, Winsvold, B, Palta, P, Farh, K, Cuenca-Leon, E, Furlotte, N, Kurth, T, Ligthart, L, Terwindt, G, Freilinger, T, Ran, C, Gordon, S, Borck, G, Adams, H, Lehtimäki, T, Wedenoja, J, Buring, J, Schürks, M, Hrafnsdottir, M, Hottenga, J, Penninx, B, Artto, V, Kaunisto, M, Vepsäläinen, S, Martin, N, Montgomery, G, Kurki, M, Hämäläinen, E, Huang, H, Huang, J, Sandor, C, Webber, C, Muller-Myhsok, B, Schreiber, S, Salomaa, V, Loehrer, E, Göbel, H, Macaya, A, Pozo-Rosich, P, Hansen, T, Werge, T, Kaprio, J, Metspalu, A, Kubisch, C, Ferrari, M, Belin, A, Van Den Maagdenberg, A, Zwart, J, Boomsma, D, Eriksson, N, Olesen, J, Chasman, D, Nyholt, D, Avbersek, A, Baum, L, Berkovic, S, Bradfield, J, Buono, R, Catarino, C, Cossette, P, De Jonghe, P, Depondt, C, Dlugos, D, Ferraro, T, French, J, Hjalgrim, H, Jamnadas-Khoda, J, Kälviäinen, R, Kunz, W, Lerche, H, Leu, C, Lindhout, D, Lo, W, Lowenstein, D, Mccormack, M, Møller, R, Molloy, A, Ng, P, Oliver, K, Privitera, M, Radtke, R, Ruppert, A, Sander, T, Schachter, S, Schankin, C, Scheffer, I, Schoch, S, Sisodiya, S, Smith, P, Sperling, M, Striano, P, Surges, R, Neil Thomas, G, Visscher, F, Whelan, C, Zara, F, Heinzen, E, Marson, A, Becker, F, Stroink, H, Zimprich, F, Gasser, T, Gibbs, R, Heutink, P, Martinez, M, Morris, H, Sharma, M, Ryten, M, Mok, K, Pulit, S, Bevan, S, Holliday, E, Attia, J, Battey, T, Boncoraglio, G, Thijs, V, Chen, W, Mitchell, B, Rothwell, P, Sharma, P, Sudlow, C, Vicente, A, Markus, H, Kourkoulis, C, Pera, J, Raffeld, M, Silliman, S, Perica, V, Thornton, L, Huckins, L, William Rayner, N, Lewis, C, Gratacos, M, Rybakowski, F, Keski-Rahkonen, A, Raevuori, A, Hudson, J, Reichborn-Kjennerud, T, Monteleone, P, Karwautz, A, Mannik, K, Baker, J, O'Toole, J, Trace, S, Davis, O, Helder, S, Ehrlich, S, Herpertz-Dahlmann, B, Danner, U, Van Elburg, A, Clementi, M, Forzan, M, Docampo, E, Lissowska, J, Hauser, J, Tortorella, A, Maj, M, Gonidakis, F, Tziouvas, K, Papezova, H, Yilmaz, Z, Wagner, G, Cohen-Woods, S, Herms, S, Julia, A, Rabionet, R, Dick, D, Ripatti, S, Andreassen, O, Espeseth, T, Lundervold, A, Steen, V, Pinto, D, Scherer, S, Aschauer, H, Schosser, A, Alfredsson, L, Padyukov, L, Halmi, K, Mitchell, J, Strober, M, Bergen, A, Kaye, W, Szatkiewicz, J, Cormand, B, Ramos-Quiroga, J, Sánchez-Mora, C, Ribasés, M, Casas, M, Hervas, A, Arranz, M, Haavik, J, Zayats, T, Johansson, S, Williams, N, Dempfle, A, Rothenberger, A, Kuntsi, J, Oades, R, Banaschewski, T, Franke, B, Buitelaar, J, Vasquez, A, Doyle, A, Reif, A, Lesch, K, Freitag, C, Rivero, O, Palmason, H, Romanos, M, Langley, K, Rietschel, M, Witt, S, Dalsgaard, S, Børglum, A, Waldman, I, Wilmot, B, Molly, N, Bau, C, Crosbie, J, Schachar, R, Loo, S, Mcgough, J, Grevet, E, Medland, S, Robinson, E, Weiss, L, Bacchelli, E, Bailey, A, Bal, V, Battaglia, A, Betancur, C, Bolton, P, Cantor, R, Celestino-Soper, P, Dawson, G, De Rubeis, S, Duque, F, Green, A, Klauck, S, Leboyer, M, Levitt, P, Maestrini, E, Mane, S, Moreno-De-Luca, D, Parr, J, Regan, R, Reichenberg, A, Sandin, S, Vorstman, J, Wassink, T, Wijsman, E, Cook, E, Santangelo, S, Delorme, R, Roge, B, Magalhaes, T, Arking, D, Schulze, T, Thompson, R, Strohmaier, J, Matthews, K, Melle, I, Morris, D, Blackwood, D, Mcintosh, A, Bergen, S, Schalling, M, Jamain, S, Maaser, A, Fischer, S, Reinbold, C, Fullerton, J, Guzman-Parra, J, Mayoral, F, Schofield, P, Cichon, S, Mühleisen, T, Degenhardt, F, Schumacher, J, Bauer, M, Mitchell, P, Gershon, E, Rice, J, Potash, J, Zandi, P, Craddock, N, Nicol Ferrier, I, Alda, M, Rouleau, G, Turecki, G, Ophoff, R, Pato, C, Anjorin, A, Stahl, E, Leber, M, Czerski, P, Cruceanu, C, Jones, I, Posthuma, D, Andlauer, T, Forstner, A, Streit, F, Baune, B, Air, T, Sinnamon, G, Wray, N, Macintyre, D, Porteous, D, Homuth, G, Rivera, M, Grove, J, Middeldorp, C, Hickie, I, Pergadia, M, Mehta, D, Smit, J, Jansen, R, De Geus, E, Dunn, E, Li, Q, Nauck, M, Schoevers, R, Beekman, A, Knowles, J, Viktorin, A, Arnold, P, Barr, C, Bedoya-Berrio, G, Joseph Bienvenu, O, Brentani, H, Burton, C, Camarena, B, Cappi, C, Cath, D, Cavallini, M, Cusi, D, Darrow, S, Denys, D, Derks, E, Dietrich, A, Fernandez, T, Figee, M, Freimer, N, Gerber, G, Grados, M, Greenberg, E, Hanna, G, Hartmann, A, Hirschtritt, M, Hoekstra, P, Huang, A, Huyser, C, Illmann, C, Jenike, M, Kuperman, S, Leventhal, B, Lochner, C, Lyon, G, Macciardi, F, Madruga-Garrido, M, Malaty, I, Maras, A, Mcgrath, L, Miguel, E, Mir, P, Nestadt, G, Nicolini, H, Okun, M, Pakstis, A, Paschou, P, Piacentini, J, Pittenger, C, Plessen, K, Ramensky, V, Ramos, E, Reus, V, Richter, M, Riddle, M, Robertson, M, Roessner, V, Rosário, M, Samuels, J, Sandor, P, Stein, D, Tsetsos, F, Van Nieuwerburgh, F, Weatherall, S, Wendland, J, Wolanczyk, T, Worbe, Y, Zai, G, Goes, F, Mclaughlin, N, Nestadt, P, Grabe, H, Depienne, C, Konkashbaev, A, Lanzagorta, N, Valencia-Duarte, A, Bramon, E, Buccola, N, Cahn, W, Cairns, M, Chong, S, Cohen, D, Crespo-Facorro, B, Crowley, J, Davidson, M, Delisi, L, Dinan, T, Donohoe, G, Drapeau, E, Duan, J, Haan, L, Hougaard, D, Karachanak-Yankova, S, Khrunin, A, Klovins, J, Kučinskas, V, Keong, J, Limborska, S, Loughland, C, Lönnqvist, J, Maher, B, Mattheisen, M, Mcdonald, C, Murphy, K, Nenadic, I, Van Os, J, Pantelis, C, Pato, M, Petryshen, T, Quested, D, Roussos, P, Sanders, A, Schall, U, Schwab, S, Sim, K, So, H, Stögmann, E, Subramaniam, M, Toncheva, D, Waddington, J, Walters, J, Weiser, M, Cheng, W, Cloninger, R, Curtis, D, Gejman, P, Henskens, F, Mattingsdal, M, Oh, S, Scott, R, Webb, B, Breen, G, Churchhouse, C, Bulik, C, Daly, M, Dichgans, M, Faraone, S, Guerreiro, R, Holmans, P, Kendler, K, Koeleman, B, Mathews, C, Price, A, Scharf, J, Sklar, P, Williams, J, Wood, N, Cotsapas, C, Palotie, A, Smoller, J, Sullivan, P, Rosand, J, Corvin, A, Neale, B, Kauwe, John S. K., Mcquillin, Andrew, Adams, Hieab H. H., Mccormack, Mark, Bau, Claiton H. D., Mcgough, James J., Mcintosh, Andrew, Andlauer, Till F. M., Macintyre, Donald J., Mcgrath, Lauren, Mclaughlin, Nicole, Delisi, Lynn, Mcdonald, Colm, Université Montpellier 1 (UM1)-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Vrije universiteit = Free university of Amsterdam [Amsterdam] (VU), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement (Inserm U1167 - RID-AGE - Institut Pasteur), RIKEN Center for Integrative Medical Science, Neuropsychiatrie : recherche épidémiologique et clinique, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 1 (UM1)-Université de Montpellier (UM), University of South Florida (USF), University of Zürich [Zürich] (UZH)-Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology in Zürich [Zürich] (ETH Zürich), Alzheimer Precision Medicine GRC n°21 (APM), CHU Pitié-Salpêtrière [APHP], Cardiff University-Medical Research Council, Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Aix Marseille Université (AMU), Johannes Kepler University Linz [linz] (JKU), Washington University in St Louis, Charité - Universitätsmedizin Berlin / Charite - University Medicine Berlin, Universitat Autònoma de Barcelona [Barcelona] (UAB), Hôpital Erasme (Bruxelles), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Jagiellonian University [Krakow] (UJ), Technische Universität Dresden (TUD), National and Kapodistrian University of Athens = University of Athens (NKUA | UoA), Charles University [Prague], Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), University of Bergen (UIB), University Medicine Goettingen, Università di Bologna [Bologna] (UNIBO), Forschungszentrum Jülich GmbH, UNSW Medicine [Sydney], McGill University, Universidad de Antioquia, University of Florida [Gainesville], Universiteit Gent [Ghent], Service Psychiatrie de l'Enfant et de l'Adolescent [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP], University of Wollongong, Alzheimer Precision Medicine [CHU Pitié-Salpétriêre] (GRC 21 APM), Anttila, Verneri [0000-0002-0073-4675], Finucane, Hilary K [0000-0003-3864-9828], Walters, Raymond K [0000-0001-8422-6530], Duncan, Laramie [0000-0003-1131-661X], Escott-Price, Valentina [0000-0003-1784-5483], Falcone, Guido J [0000-0002-6407-0302], Gormley, Padhraig [0000-0002-8908-6968], Malik, Rainer [0000-0001-9212-2520], Ripke, Stephan [0000-0003-3622-835X], Wei, Zhi [0000-0001-6059-4267], Yu, Dongmei [0000-0001-7901-4365], Lee, Phil H [0000-0003-1770-3100], Breen, Gerome [0000-0003-2053-1792], Bulik, Cynthia M [0000-0001-7772-3264], Daly, Mark [0000-0002-0949-8752], Dichgans, Martin [0000-0002-0654-387X], Faraone, Stephen V [0000-0002-9217-3982], Holmans, Peter [0000-0003-0870-9412], Koeleman, Bobby [0000-0001-7749-182X], Mathews, Carol A [0000-0003-2208-7058], Sklar, Pamela [0000-0001-9715-4943], Williams, Julie [0000-0002-4069-0259], Wood, Nicholas W [0000-0002-9500-3348], Cotsapas, Chris [0000-0002-7772-5910], Smoller, Jordan W [0000-0002-0381-6334], Sullivan, Patrick [0000-0002-6619-873X], Rosand, Jonathan [0000-0002-1014-9138], Corvin, Aiden [0000-0001-6717-4089], Neale, Benjamin M [0000-0003-1513-6077], and Apollo - University of Cambridge Repository
Subjects: Etiology, [SDV]Life Sciences [q-bio], MESH: Brain Diseases, body-mass index, genetics [Mental Disorders], Disorders of the Brain, Risks factors, classification [Mental Disorders], MESH: Quantitative Trait, Heritable, MESH: Risk Factors, Risk Factors, MESH: Genetic Variation, alzheimers-disease, 610 Medicine & health, bipolar disorder, Brain Diseases, deficit hyperactivity disorder, Multidisciplinary, Mental Disorders, genetics [Brain Diseases], Brain Disease, Brain, Genetic Variation, Genome-Wide Association Study, Humans, Phenotype, Quantitative Trait, Heritable, Psychiatric Disorders, anorexia-nervosa, Mental Disorder, Psychiatric Genomics, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], long-term survival, Engineering sciences. Technology, Human, General Science & Technology, population-based twin, diagnosis [Mental Disorders], MESH: Phenotype, Neurological Disorders, Quantitative Trait, MD Multidisciplinary, MESH: Mental Disorders, diagnosis [Brain Diseases], Heritable, genetic correlations, [SDV.GEN]Life Sciences [q-bio]/Genetics, MESH: Humans, major depressive disorder, Risk Factor, Brain Diseases/classification, Brain Diseases/diagnosis, Brain Diseases/genetics, Mental Disorders/classification, Mental Disorders/diagnosis, Mental Disorders/genetics, classification [Brain Diseases], Perturbações do Desenvolvimento Infantil e Saúde Mental, ddc:320, MESH: Genome-Wide Association Study, genome-wide association, Brainstorm Consortium, Genetic Factors, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: INTRODUCTION Brain disorders may exhibit shared symptoms and substantial epidemiological comorbidity, inciting debate about their etiologic overlap. However, detailed study of phenotypes with different ages of onset, severity, and presentation poses a considerable challenge. Recently developed heritability methods allow us to accurately measure correlation of genome-wide common variant risk between two phenotypes from pools of different individuals and assess how connected they, or at least their genetic risks, are on the genomic level. We used genome-wide association data for 265,218 patients and 784,643 control participants, as well as 17 phenotypes from a total of 1,191,588 individuals, to quantify the degree of overlap for genetic risk factors of 25 common brain disorders. RATIONALE Over the past century, the classification of brain disorders has evolved to reflect the medical and scientific communities’ assessments of the presumed root causes of clinical phenomena such as behavioral change, loss of motor function, or alterations of consciousness. Directly observable phenomena (such as the presence of emboli, protein tangles, or unusual electrical activity patterns) generally define and separate neurological disorders from psychiatric disorders. Understanding the genetic underpinnings and categorical distinctions for brain disorders and related phenotypes may inform the search for their biological mechanisms. RESULTS Common variant risk for psychiatric disorders was shown to correlate significantly, especially among attention deficit hyperactivity disorder (ADHD), bipolar disorder, major depressive disorder (MDD), and schizophrenia. By contrast, neurological disorders appear more distinct from one another and from the psychiatric disorders, except for migraine, which was significantly correlated to ADHD, MDD, and Tourette syndrome. We demonstrate that, in the general population, the personality trait neuroticism is significantly correlated with almost every psychiatric disorder and migraine. We also identify significant genetic sharing between disorders and early life cognitive measures (e.g., years of education and college attainment) in the general population, demonstrating positive correlation with several psychiatric disorders (e.g., anorexia nervosa and bipolar disorder) and negative correlation with several neurological phenotypes (e.g., Alzheimer’s disease and ischemic stroke), even though the latter are considered to result from specific processes that occur later in life. Extensive simulations were also performed to inform how statistical power, diagnostic misclassification, and phenotypic heterogeneity influence genetic correlations. CONCLUSION The high degree of genetic correlation among many of the psychiatric disorders adds further evidence that their current clinical boundaries do not reflect distinct underlying pathogenic processes, at least on the genetic level. This suggests a deeply interconnected nature for psychiatric disorders, in contrast to neurological disorders, and underscores the need to refine psychiatric diagnostics. Genetically informed analyses may provide important “scaffolding” to support such restructuring of psychiatric nosology, which likely requires incorporating many levels of information. By contrast, we find limited evidence for widespread common genetic risk sharing among neurological disorders or across neurological and psychiatric disorders. We show that both psychiatric and neurological disorders have robust correlations with cognitive and personality measures. Further study is needed to evaluate whether overlapping genetic contributions to psychiatric pathology may influence treatment choices. Ultimately, such developments may pave the way toward reduced heterogeneity and improved diagnosis and treatment of psychiatric disorders.
Published: 2018

22. Viewpoint oscillation improves the perception of distance travelled in static observers but not during treadmill walking

Author: Martin Bossard, Daniel Mestre, Cédric Goulon, School of Psychology [Cardiff University], Cardiff University, Institut des Sciences du Mouvement Etienne Jules Marey (ISM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), and Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)
Subjects: Adult, Male, media_common.quotation_subject, Motion Perception, Optical head-mounted display, Walking, Treadmill walking, 050105 experimental psychology, 03 medical and health sciences, [SCCO]Cognitive science, Young Adult, 0302 clinical medicine, Perception, Humans, 0501 psychology and cognitive sciences, Computer vision, Treadmill, Immersive display, media_common, Head oscillations, business.industry, Oculus rift, Oscillation, General Neuroscience, [SCCO.NEUR]Cognitive science/Neuroscience, Distance Perception, Optic flow, 05 social sciences, Virtual Reality, Proprioception, Viewpoint oscillations, [SCCO.PSYC]Cognitive science/Psychology, Female, Self-motion, Artificial intelligence, business, Psychology, 030217 neurology & neurosurgery, Research Article, Distance travelled estimation
Abstract: Optic flow has been found to be a significant cue for static observers’ perception of distance travelled. In previous research conducted in a large-scale immersive display (CAVE), adding viewpoint oscillations to a radial optic flow simulating forward self-motion was found to modulate this perception. In the present two experiments, we investigated (1) whether the improved distance travelled perceptions observed with an oscillating viewpoint in a CAVE were also obtained when the subjects were wearing a head mounted display (HMD, an Oculus Rift) and (2) whether the absence of viewpoint oscillations during treadmill walking was liable to affect the subjects’ perception of self-motion. In Experiment 1, static observers performed a distance travelled estimation task while facing either a purely linear visual simulation of self-motion (in depth) or the same flow in addition to viewpoint oscillations based on the subjects’ own head oscillations previously recorded during treadmill walking. Results show that the benefits of viewpoint oscillations observed in a CAVE persisted when the participants were wearing an HMD. In Experiment 2, participants had to carry out the same task while walking on a treadmill under two different visual conditions simulating self-motion in depth: the one with and the other without the visual consequences of their head translations. Results showed that viewpoint oscillations did not improve the accuracy of subjects’ distance travelled estimations. A comparison between the two experiments showed that adding internal dynamic information about actual self-motion to visual information did not allow participants better estimates.
Published: 2018

23. Reduced Cancer Incidence in Huntington's Disease: Analysis in the Registry Study

Author: McNulty, Paul, Pilcher, Richard, Ramesh, Raviram, Necuiniate, Renata, Hughes, Alis, Farewell, Daniel, Holmans, Peter, Jones, Lesley, Verny, Christophe, Gohier, Bénédicte, School of Psychology [Cardiff University], Cardiff University, MRC Centre for Neuropsychiatric Genetics and Genomics, Medical Research Council-Cardiff University, Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Laboratoire de Psychologie des Pays de la Loire (LPPL), Université d'Angers (UA)-Université de Nantes - UFR Lettres et Langages (UFRLL), and Université de Nantes (UN)-Université de Nantes (UN)
Subjects: [SHS]Humanities and Social Sciences
Abstract: International audience; BACKGROUND: People with Huntington's disease (HD) have been observed to have lower rates of cancers.OBJECTIVE: To investigate the relationship between age of onset of HD, CAG repeat length, and cancer diagnosis.METHODS: Data were obtained from the European Huntington's disease network REGISTRY study for 6540 subjects. Population cancer incidence was ascertained from the GLOBOCAN database to obtain standardised incidence ratios of cancers in the REGISTRY subjects.RESULTS: 173/6528 HD REGISTRY subjects had had a cancer diagnosis. The age-standardised incidence rate of all cancers in the REGISTRY HD population was 0.26 (CI 0.22-0.30). Individual cancers showed a lower age-standardised incidence rate compared with the control population with prostate and colorectal cancers showing the lowest rates. There was no effect of CAG length on the likelihood of cancer, but a cancer diagnosis within the last year was associated with a greatly increased rate of HD onset (Hazard Ratio 18.94, p CONCLUSIONS: Cancer is less common than expected in the HD population, confirming previous reports. However, this does not appear to be related to CAG length in HTT. A recent diagnosis of cancer increases the risk of HD onset at any age, likely due to increased investigation following a cancer diagnosis.
Published: 2018

24. PERCEPTION VISUELLE DU MOUVEMENT PROPRE : Effets des mouvements de la tête durant la marche sur l’estimation de la distance parcourue à partir du flux optique

Author: Bossard, Martin, School of Psychology [Cardiff University], Cardiff University, Aix-Marseile Université, and Daniel Mestre
Subjects: [SCCO]Cognitive science, intégration de trajet, travelled distance perception, perception du mouvement propre, [SCCO.PSYC]Cognitive science/Psychology, optic flow, path integration, perception de la distance parcourue, flux optique, self-motion perception
Abstract: When exploring their environment, humans and other animals have the ability to use many sources of information to estimate the distance they travel. Several studies have shown that optic flow is a significant cue to perceive distance travelled. Furthermore, it was found that adding various viewpoint oscillations to a purely translational optic flow, simulating forward self-motion, modulated this perception. In a series of experiments, we tested whether the perception of distance travelled was also affected by viewpoint oscillation, similar to head motion during natural walking. A first series of experiments, participants were exposed to an immersive optic flow simulating forward self-motion and they were asked to indicate when they thought they had reached the remembered position of a previously seen target. The main conclusion from these experiments is that viewpoint oscillations improve the perception of distance travelled. Moreover, this effect appears to be linked to an increase in global retinal motion. However, the "ecological" contribution cannot be ruled out. Manipulating different viewpoint oscillation frequencies showed that the optimal performance was observed for a range of frequencies close to that observed for the head motion during natural walking. Two further experiments aimed to test whether the idiosyncrasy of viewpoint oscillations affects the perception of distance travelled in stationary observers and whether the absence of their own viewpoint oscillation played an important role in subjects’ estimates, while they were walking on a treadmill. And finally, in a last experiment we tried to develop a dynamic measure of distance travelled to a previously seen target, with a continuous pointing task method. Overall, our results show that viewpoint oscillations play an important role in visual self-motion perception and that several parameters (including visual information, proprioceptive information and ecological aspects of natural walking) seem to be involved in this process.; Lorsqu’ils explorent leur environnement, les humains comme les autres animaux ont la capacité d’utiliser de nombreuses sources d’information afin d’estimer la distance qu’ils parcourent. De nombreuses études ont montré que le flux optique est un indice important dans la perception de la distance parcourue. De plus, il a été montré que l’ajout d’un point de vue oscillant à une simulation visuelle de mouvement propre vers l’avant modulait cette perception par rapport à une simulation visuelle de mouvement purement linéaire. A travers ce travail doctoral, nous nous sommes intéressés à tester si la perception de la distance parcourue était également affectée par un point de vue oscillant, mimant de manière plus ou moins fidèle les mouvements de la tête lors de la marche. Dans une première série d’expériences, il était demandé aux participants, confrontés à un flux optique immersif simulant leur propre mouvement vers l’avant, d’indiquer quand ils pensaient avoir atteint la position d’une cible distante initialement perçue. La conclusion principale de ces expérimentations est qu’un point de vue oscillant améliore la perception de la distance parcourue. De plus, cet effet semble être lié à une augmentation du mouvement rétinien provoqué par l’oscillation du point de vue. Toutefois la contribution « écologique » ne peut pas être exclue. En effet, la manipulation de la fréquence de cette oscillation montre que les performances optimales sont observées pour une gamme de fréquences proche de celle observée pour le mouvement de la tête résultant de la fréquence de pas pendant la marche naturelle. Deux expériences subséquentes se sont intéressées à déterminer si le caractère idiosyncratique du point de vue oscillant affectait la perception de la distance parcourue d’observateurs stationnaires et si l’absence de ces oscillations jouait un rôle important dans l’estimation de la distance parcourue lorsqu’ils marchaient sur un tapis roulant. Enfin, dans une dernière expérience nous avons essayé de développer une mesure dynamique de la distance parcourue à travers l’utilisation d’une tâche demandant aux participants de pointer continuellement la position d’une cible distante initialement perçue. Dans l’ensemble, nos résultats montrent qu’un point de vue oscillant joue un rôle important dans la perception visuelle du mouvement propre et que de nombreux paramètres semblent être impliqués dans ce processus, incluant les informations visuelles et proprioceptives mais également l’aspect écologique de la marche naturelle.
Published: 2018
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25. Speech intelligibility prediction in reverberation: Towards an integrated model of speech transmission, spatial unmasking, and binaural de-reverberation

Author: Mathieu Lavandier, John F. Culling, Thibaud Leclère, École Nationale des Travaux Publics de l'État (ENTPE), Laboratoire Génie Civil et Bâtiment (LGCB), Ecole Nationale des Travaux Publics de l’Etat, LGCB CNRS 5513 - CeLyA Université de Lyon, Vaulx-en-Velin Cedex, France, School of Psychology [Cardiff University], and Cardiff University
Subjects: Masking (art), Reverberation, Sound Spectrography, Time Factors, Acoustics and Ultrasonics, Voice Quality, Computer science, Acoustics, Ambient noise level, BF, Models, Psychological, Intelligibility (communication), Vibration, Speech Acoustics, Architectural acoustics, Arts and Humanities (miscellaneous), Humans, ComputingMilieux_MISCELLANEOUS, [SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], Speech Reception Threshold Test, Speech Intelligibility, Reproducibility of Results, Noise, Acoustic Stimulation, Facility Design and Construction, Speech Perception, Perceptual Masking, Binaural recording
Abstract: Room acoustic indicators of intelligibility have focused on the effects of temporal smearing of speech by reverberation and masking by diffuse ambient noise. In the presence of a discrete noise source, these indicators neglect the binaural listener's ability to separate target speech from noise. Lavandier and Culling [(2010). J. Acoust. Soc. Am. 127, 387–399] proposed a model that incorporates this ability but neglects the temporal smearing of speech, so that predictions hold for near-field targets. An extended model based on useful-to-detrimental (U/D) ratios is presented here that accounts for temporal smearing, spatial unmasking, and binaural de-reverberation in reverberant environments. The influence of the model parameters was tested by comparing the model predictions with speech reception thresholds measured in three experiments from the literature. Accurate predictions were obtained by adjusting the parameters to each room. Room-independent parameters did not lead to similar performances, suggesting that a single U/D model cannot be generalized to any room. Despite this limitation, the model framework allows to propose a unified interpretation of spatial unmasking, temporal smearing, and binaural de-reverberation.\ud I. INTRODU
Published: 2015

26. Long-term sensorimotor and therapeutical effects of a mild regime of prism adaptation in spatial neglect

Author: Denis Pélisson, Shaun Gallagher, Sophie Jacquin-Courtois, Nadia Alahyane, Jacques Luauté, Gilles Rode, Patrice Revol, Peter W. Halligan, S. Lacour, Laure Pisella, Carine Michel, Yves Rossetti, Médecine Physique et Réadaptation [Hôpital Henry Gabrielle - Lyon], Hôpital Henry Gabrielle [CHU - HCL], Hospices Civils de Lyon ( HCL ) -Hospices Civils de Lyon ( HCL ), Centre de recherche en neurosciences de Lyon ( CRNL ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] ( UJM ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Plate-forme Mouvement et handicap [Hôpital Henry Gabrielle - Lyon], Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] ( CAPS ), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Department of Philosophy [University of Memphis], University of Memphis, School of Psychology [Cardiff University], Cardiff University, Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Centre de recherche en neurosciences de Lyon (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] (CAPS), and Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: Adult, Male, medicine.medical_specialty, genetic structures, media_common.quotation_subject, medicine.medical_treatment, Neglect, law.invention, Perceptual Disorders, Double blind, Physical medicine and rehabilitation, Double-Blind Method, Randomized controlled trial, Feedback, Sensory, law, medicine, Humans, Attention, Orthopedics and Sports Medicine, Stroke, Hemineglect, Aged, media_common, Spatial neglect, Rehabilitation, Cognition, Middle Aged, medicine.disease, Adaptation, Physiological, Functional Independence Measure, Treatment Outcome, Prism adaptation, Space Perception, [ SDV.NEU ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Egocentric reference, Visual Perception, Physical therapy, Female, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Bottom-up, Psychology, Psychomotor Performance, RCT
Abstract: International audience; Spatial neglect (SN) is commonly associated with poor functional outcome. Adaptation to a rightward optical deviation of vision has been shown to benefit to SN rehabilitation. The neurophysiological foundations and the optimal modalities of prism adaptation (PA) therapy however remain to be validated. This study is aimed at exploring the long-term sensory-motor, cognitive and functional effects produced by weekly PA sessions over a period of four weeks. A double-blind, monocentric randomized and controlled trial (RCT) was carried out. Twenty patients with left SN secondary to stroke were included, 10 in the “prism” group and 10 in the “control” group. The sensory-motor effects of PA were evaluated by measurement of manual and visual straight-ahead, and also by precision of pointing without visual feedback before and after each PA session. The functional independence measure (FIM) was evaluated before and at 1, 3 and 6 months after PA, while SN severity was assessed using the Behavioural Inattention Test (BIT) before and 6 months after PA. Before the intervention, only manual straight-ahead pointing constituted a reproducible sensory-motor measurement. During prism exposure, a questionnaire showed that not a single patient were aware of the direct effects of optical deviation on pointing movement performance. The sensory-motor after-effects produced by the PA produced a more rapid reduction of the rightward manual straight-ahead, which was secondarily followed by visual straight-ahead. These sensory-motor effects helped to clarify the action mechanisms of PA on SN. At the conclusion of the 6-month follow-up, the two groups showed similar improvement, indicating that a weekly PA session over 4 weeks was not sufficient to produce long-term functional benefit. This improvement was correlated with the evolution of visual straight-ahead, which can be proposed as a marker for patients outcome.
Published: 2015
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27. Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

Author: John Hardy, Nick C. Fox, Lena Lilius, Christine Van Broeckhoven, Mindy J. Katz, Carlos Cruchaga, Joshua W. Miller, Carol Brayne, Letizia Concari, Christopher Shaw, Minerva M. Carrasquillo, Richard Mayeux, Anne Boland, Charles DeCarli, Helena C. Chui, Laura B. Cantwell, Yoland Aladro Benito, Chuang Kuo Wu, Elaine R. Peskind, Andrew McDavid, M. Ilyas Kamboh, Amanda Smith, Pascual Sánchez-Juan, Jean-François Deleuze, Jayanadra J. Himali, Thomas H. Mosley, Thomas J. Montine, Chuanhai Cao, Andreas J. Forstner, Thomas G. Beach, Robert Barber, Miquel Aguilar, Liming Qu, Jerome I. Rotter, Matthew J. Huentelman, Christiane Reitz, Christopher J. O'Donnell, Steven G. Younkin, Bradley T. Hyman, Bruce L. Miller, Rachelle S. Doody, Eric B. Larson, Ronald L. Hamilton, Todd E. Golde, Steven E. Arnold, Melissa E. Garcia, Rachel Raybould, Lena Kilander, Mark A. Sager, Kevin Morgan, Kathryn L. Lunetta, William Perry, Joseph D. Buxbaum, Craig S. Atwood, Thomas D. Bird, Michael Conlon O'Donovan, Robert Olaso, Juan Fortea, Susanne Moebus, Lisa L. Barnes, Rachel Marshall, Huntington Potter, Mercè Boada, Shahzad Ahmad, Paolo Caffarra, Daniel C. Marson, Jonathan L. Haines, Perrie M. Adams, John M Olichney, Lars Lannfelt, Stefanie Heilmann-Heimbach, Markus M. Nöthen, Shubhabrata Mukherjee, John Malamon, Xue Wang, Christopher S. Carlson, Karen Ritchie, Roger N. Rosenberg, Paul K. Crane, Alexa S. Beiser, Céline Bellenguez, Robert C. Green, Maria Urbano, Petra Proitsi, John Powell, Elisa Majounie, Ammar Al-Chalabi, Hakon Hakonarson, Yogen Patel, Martin Scherer, Julie Williams, Richard B. Lipton, Vincent Dermecourt, Adam L. Boxer, Gerard D. Schellenberg, David G. Clark, Anita L. DeStefano, Joel H. Kramer, Victoria Alvarez, Nandini Badarinarayan, Oscar L. Lopez, Chris Corcoran, Ubaldo Bonuccelli, Donald R. Royall, James Bowen, Monica Diez Fairen, Tricia A. Thornton-Wells, Nilufer Ertekin-Taner, Florence Pasquier, Martin Ingelsson, Yi Zhao, John R. Gilbert, Valentina Escott-Price, Amanda B. Kuzma, Fabienne Garzia, Reinhard Heun, Otto Valladares, Andrew J. Saykin, Sara Ortega-Cubero, Liana G. Apostolova, Henry L. Paulson, John K Kauwe, Imelda Barber, Carolina Ceballos Diaz, Douglas Galasko, M. Arfan Ikram, Lluís Tárraga, Carlo Caltagirone, Joan S. Reisch, Wolfgang Maier, Bruno Vellas, Rebecca Sims, Angela Hodges, Matthew P. Frosch, Isabel Henández, Annakaisa Haapasalo, Thor Aspelund, Håkan Thonberg, Aimee Pierce, Roger L. Albin, Wayne W. Poon, Rebecca Sussams, Amy Braddel, Ranjan Duara, Albert V. Smith, Kirk C. Wilhelmsen, Gianfranco Spalletta, Simon Lovestone, Peter Passmore, Ana Frank-García, Cynthia M. Carlsson, Jade Chapman, Nathan D. Price, Philip L. De Jager, John M. Ringman, Seung Hoan Choi, Nicola Denning, Michael John Owen, Clinton T. Baldwin, Amalia C. Bruni, Denis A. Evans, Rudolph E. Tanzi, Dominique Campion, Laura Fratiglioni, Alberto Lleó, Per Hoffmann, Carole Dufouil, Charlotte Forsell, Alun Meggy, Charlene Thomas, Robert S. Stern, James B. Leverenz, Tatiana Foroud, William W. Seeley, James J. Lah, Brian A. Lawlor, Kenneth B. Fallon, Matthias Riemenschneider, Ryan M. Huebinger, Regina M. Carney, Clinton B. Wright, Didier Hannequin, Deborah Blacker, Anne Kinhult-Ståhlbom, Ekaterina Rogaeva, Andrew P. Lieberman, Bernardino Ghetti, Linda J. Van Eldik, Bernadette McGuinness, Thomas Fairchild, Margaret A. Pericak-Vance, Ashok Raj, Reinhold Schmidt, Ronald C. Petersen, Harald Hampel, María J. Bullido, Steven L. Carroll, Maria Candida Deniz Naranjo, Kathleen A. Welsh-Bohmer, Myriam Fornage, Joseph F. Quinn, Caroline Graff, Claudia L. Satizabal, Patrice L. Whitehead, David Wallon, Christopher Medway, Lindsay A. Farrer, Vilmundur Gudnason, Peter St George-Hyslop, Pau Pastor, Frank Jessen, Erin L. Abner, Johanna Jakobsdottir, Hieab H.H. Adams, Roberta Cecchetti, Walter A. Kukull, Thomas S. Wingo, Michelle K. Lupton, Valur Emilsson, Susan M. McCurry, Simon Mead, Hilkka Soininen, Sandra Weintraub, Amy Gerrish, Lindy E. Harrell, Lina Keller, Jean-Charles Lambert, Denise Harold, Stephen Todd, Wei Gu, Maura Gallo, Najaf Amin, Lenore J. Launer, Eleonora Sacchinelli, Mikko Hiltunen, Cécile Dulary, Eliecer Coto, Xueqiu Jian, Nathalie Fievet, Patrizia Mecocci, Sarah Taylor, Eric Boerwinkle, Maria Serpente, Ronald G. Munger, Ina Giegling, Carlo Masullo, Aoibhinn Lynch, Eliezer Masliah, Anne M. Koivisto, Chang En Yu, Qiong Yang, Benedetta Nacmias, Wayne C. McCormick, Kristelle Brown, Alessio Squassina, Deborah C. Mash, Brian W. Kunkle, Makrina Daniilidou, Alison Goate, David Carrell, Kara L. Hamilton-Nelson, Sandra Barral, Vincent Chouraki, Kristel Sleegers, Frank J. Wolters, Joseph E. Parisi, Iwona Kłoszewska, Ronald C. Kim, Sonia Moreno-Grau, Marina Arcaro, Carmen Muñoz Fernadez, Vernon S. Pankratz, Duane Beekly, Sabrina Pichler, Gislain Septier, Delphine Bacq, Amanda J. Myers, Adam C. Naj, Frank Martiniuk, Sudha Seshadri, Badri N. Vardarajan, Joshua A. Sonnen, M.-Marsel Mesulam, Howard J. Rosen, James T. Becker, Chiara Fenoglio, Ge Li, Alberto Pilotto, Mary Sano, Olivier Hanon, Honghuang Lin, Jean Paul G. Vonsattel, W. T. Longstreth, Daniela Galimberti, David C. Rubinsztein, RoseMarie Brundin, Vilmantas Giedraitis, Christine M. Hulette, Peter Holmans, Martin Dichgans, Maria Vronskaya, Céline Derbois, Michelangelo Mancuso, Constantine G. Lyketsos, Christophe Tzourio, Jacques Epelbaum, Raffaele Maletta, Mariet Allen, Hong-Dong Li, James R. Burke, Rik Vandenberghe, David G. Mann, Bruce M. Psaty, Lawrence S. Honig, Beth A. Dombroski, Erik D. Roberson, Cornelia M. van Duijn, Benjamin Grenier-Boley, Seppo Helisalmi, Jean-François Dartigues, Russell H. Swerdlow, Paola Bossù, Ashley R. Winslow, Elio Scarpini, Lesley Jones, Sebastien Engelborghs, John Q. Trojanowski, Jeffrey Kaye, Jenny Lord, Chiara Cupidi, Janet A. Johnston, Dan Rujescu, Feroze Golamaully, Anne Braae, Rafael Blesa, L. Adrienne Cupples, Dennis W. Dickson, Gail P. Jarvik, David W. Fardo, David H. Cribbs, Michael Gill, Jose Bras, Allan I. Levey, Jennifer Williamson, Rhodri Thomas, John C. Morris, Lei Yu, Debby W. Tsuang, Annette M. Hartmann, John H. Growdon, John Collinge, Claudine Berr, Fernando Rivadeneira, Oliver Peters, Albert Hofman, Frank M. LaFerla, Vivianna M. Van Deerlin, James Uphill, David A. Bennett, Onofre Combarros, Gudny Eiriksdottir, Jeremy D. Burgess, Melanie L. Dunstan, Elizabeth Crocco, Keeley J. Brookes, Robert R. Graham, Lon S. Schneider, Eden R. Martin, Matt Hill, Neill R. Graff-Radford, Joseph T. Hughes, Vincenzo Solfrizzi, Taniesha Morgan, Antonio Ciaramella, Bruno Dubois, Juan C. Troncoso, Paolo Bosco, Jordi Clarimón, Daniel H. Geschwind, Virginia Boccardi, Barry Reisberg, Timothy W. Behrens, Annette L. Fitzpatrick, Salvatore Spina, Alexis Brice, Eileen H. Bigio, Marla Gearing, Jeffrey M. Burns, Carol A. Miller, Marilyn S. Albert, Sven J. van der Lee, Sandro Sorbi, C. Dirk Keene, Daniel Levy, Antonio Daniele, Eric M. Reiman, Paramita Chakrabarty, Oscar Sotolongo-Grau, Helena Schmidt, Francesco Panza, Murray A. Raskind, Rita Guerreiro, Gyungah Jun, Anna Karydas, Markus Leber, Harry V. Vinters, Cory C. Funk, Charles C. White, Jill R. Murrell, Sid E. O'Bryant, Nigel J. Cairns, Josée Dupuis, Ann C. McKee, Julie A. Schneider, Megan L. Grove, Malcolm B. Dick, Bradley F. Boeve, Jennifer A. Brody, Sanjay Asthana, Agustín Ruiz, Stefan Herms, Yuning Chen, David Craig, Neil W. Kowall, Maria Donata Orfei, JoAnn T. Tschanz, Florentino Sanchez Garcia, Manuel Mayhaus, Alfredo Ramirez, James Turton, André G. Uitterlinden, Davide Seripa, Lee-Way Jin, Kelley Faber, Maria C. Norton, Shuo Li, Steven H. Ferris, Steffi G. Riedel-Heller, Joshua C. Bis, Li-San Wang, Johannes Kornhuber, Peter Paul De Deyn, Martin R. Farlow, Randall L. Woltjer, Gary W. Beecham, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Erasmus University Medical Center [Rotterdam] (Erasmus MC), Hospital of the University of Pennsylvania (HUP), Perelman School of Medicine, University of Pennsylvania [Philadelphia]-University of Pennsylvania [Philadelphia], Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 (RID-AGE), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Icelandic Heart Association [Kopavogur, Iceland] (IHA), John P. Hussman Institute for Human Genomics [Miami, FL, USA], University of Miami [Coral Gables], Institut de Biologie François JACOB (JACOB), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Department of Medicine, University of Washington [Seattle], Dr. John T. Macdonald Foundation [Miami, FL, USA] (Department of Human Genetics), Epidémiologie des maladies chroniques : impact des interactions gène environnement sur la santé des populations, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé, Department of Genomics [Bonn, Germany] (Institute of Human Genetics), University of Bonn-Institute of Human Genetics [Bonn, Germany], Department of Molecular Genetics, Institut Català de Neurociències Aplicades [Barcelona, Spain], Well Advanced Solutions, Centre National de Génotypage (CNG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Translational Centre for Regenerative Medicine (TRM), Department of Cell Therapy, Universität Leipzig [Leipzig]-Universität Leipzig [Leipzig], The University of Texas Health Science Center at Houston (UTHealth), Columbia University [New York], University of Eastern Finland, Life & Brain Center - Department of Genomics, Rheinische Friedrich-Wilhelms-Universität Bonn, Génétique, Reproduction et Développement (GReD), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de la Santé et de la Recherche Médicale (INSERM), John P. Hussman Institute for Human Genomics, Neurobiologie de la Croissance et de la Senescence, Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Emmy Noether Project (SFB 833), Eberhard Karls Universität Tübingen = Eberhard Karls University of Tuebingen, Boston University [Boston] (BU), Department of Genomics, Institute for Systems Biology [Seattle, WA, USA], Universitätsklinikum Bonn (UKB), Centre of Excellence for Robotic Vision [Canberra], Australian Research Council [Canberra] (ARC), Neuroscience and Mental Health Research Institute [Cardiff, UK] (School of Medicine), Boston University School of Medicine (BUSM), Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, University of Pennsylvania [Philadelphia], Section of Neuroscience and Clinical Pharmacology, University of Cagliari, Department of Epidemiology and Biostatistics, ERASMUS, Hospital Universitario Doctor Negrín [Las Palmas de Gran Canaria, Spain], Department of Neurodegenerative Diseases, University of Mississippi Medical Center (UMMC), Pathology and Laboratory Medicine [Philadelphia, PA, USA] (Penn Neurodegeneration Genomics Center), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU), Génétique du cancer et des maladies neuropsychiatriques (GMFC), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Bioinformatics, GlaxoSmithKline, Aging Research Center [Karolinska Institutet] (ARC ), Stockholm University-Karolinska Institutet [Stockholm], University of Nottingham, UK (UON), University of Texas Health Science Center, Department of Neurobiology, Caring Sciences and Society (NVS), University of Bari Aldo Moro (UNIBA), Ageing Group, Centre for Public Health, Queen's University [Belfast] (QUB), Mayo Clinic [Jacksonville], Maurice Wohl Clinical Neuroscience Institut, King‘s College London, Istituto di Ricovero e Cura a Carattere Scientifico, Ospedale Casa Sollievo della Sofferenza [San Giovanni Rotondo] (IRCCS), Università degli Studi di Perugia (UNIPG), Framingham Heart Study, Boston University [Boston] (BU)-National Heart, Lung, and Blood Institute [Bethesda] (NHLBI), CHU Rouen, Normandie Université (NU), Universidad Autonoma de Madrid (UAM), Centro de Investigacion Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III [Madrid] (ISC), National Heart, Lung, and Blood Institute [Bethesda] (NHLBI), University of Florida [Gainesville] (UF), University of Parma = Università degli studi di Parma [Parme, Italie], Center for Cognitive Disorders AUSL [Parma, Italy], School of Public Health [Boston], Uppsala University, Institut de la Mémoire et de la Maladie d'Alzheimer [Paris] (IM2A), Université Pierre et Marie Curie - Paris 6 (UPMC), National Institute on Aging [Bethesda, USA] (NIA), National Institutes of Health [Bethesda] (NIH), Xi'an Jiaotong University (Xjtu), Department of Public health and Caring Sciences, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden, Institute of Gerontology and Geriatrics, Troubles cognitifs dégénératifs et vasculaires - U 1171 (TCDV), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Geriatric Medicine and Metabolic Diseases, Departments of Nuclear Medicine, University Medical Centre Hamburg-Eppendorf [Hamburg, Germany], University of Texas Southwestern Medical Center [Dallas], University of Cologne, Laboratoire d'Etudes et de Recherche en Informatique d'Angers (LERIA), Université d'Angers (UA), Johns Hopkins University (JHU), Universität Leipzig [Leipzig], University of Iceland [Reykjavik], Metacohorts Consortium, Harvard School of Public Health, Catholic University of Rome, Medical University Graz, Baylor College of Medicine (BCM), Baylor University, University of North Texas Health Science Center [Fort Worth], Santa Lucia Foundation (IRCCS), Nextel S.A. [Bilbao], Massachusetts General Hospital [Boston], Department of Pathology and Laboratory Medicine and Indiana Alzheimer disease Center, Indiana University School of Medicine, Indiana University System-Indiana University System, Joint Institute for the Study of the Atmosphere and Ocean (JISAO), Beijing University of Technology, University of Pittsburgh (PITT), Pennsylvania Commonwealth System of Higher Education (PCSHE), Saul B. Korey Department of Neurology, Albert Einstein College of Medicine [New York]-Yeshiva University, Utah State University (USU), Fundació per la Recerca Biomèdica i Social Mútua Terrassa [Barcelona, Spain], Hospital Universitario Mutua de Terrassa, Département de neurologie [Montpellier], Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Gui de Chauliac [Montpellier]-Université de Montpellier (UM), Department of neurology, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland, Department of neurology, University of Eastern Finland-University Hospital of Kuopio-University of Eastern Finland-University Hospital of Kuopio, Medical University of Łódź (MUL), University of Leicester, MRC Prion Unit, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, University of Milan, Fondazione Istituto di Ricerca e Cura Carattere Scientifico [Rome], Università degli Studi di Roma Tor Vergata [Roma], Saarland University Hospital, Universitat Autònoma de Barcelona (UAB), Regional Neurogenetic Centre [Lamezia Terme, Italy] (CRN - ASP Catanzaro), Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI), Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, Universidade do Porto, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Experimental and Clinical Pharmacology, St. James Hospital and Trinity College [Dublin, Ireland], School of Medicine [Dublin], Trinity College Dublin, University of Sheffield [Sheffield], Lancaster University, University of Michigan [Ann Arbor], University of Michigan System, David Geffen School of Medicine [Los Angeles], University of California [Los Angeles] (UCLA), University of California-University of California, University of Wisconsin-Madison, Rush Alzheimer Disease Center [Chicago, IL, États-Unis], Rush University Medical Center [Chicago], Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), School of Engineering [Cardiff], Department of Psychiatry [Pittsburgh], University of Pittsburgh School of Medicine, Pennsylvania Commonwealth System of Higher Education (PCSHE)-Pennsylvania Commonwealth System of Higher Education (PCSHE), Northwestern University Feinberg School of Medicine, Mayo Clinic [Rochester], Swedish Medical Center [Seattle, WA, USA], University of California [San Francisco] (UCSF), University of California, Duke University [Durham], University of Kansas Medical Center [Lawrence], Laboratory of Molecular Neuropsychiatry, Icahn School of Medicine at Mount Sinai [New York] (MSSM), Washington University in Saint Louis (WUSTL), University of South Florida [Tampa] (USF), Fred Hutchinson Cancer Research Center [Seattle] (FHCRC), Medical University of South Carolina [Charleston] (MUSC), University of Southern California (USC), Los Alamos National Laboratory (LANL), Centre de biologie du développement (CBD), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre de Biologie Intégrative (CBI), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Neurology Department, University of California, Davis (UCDavis-Neuro), University of California [Davis] (UC Davis), University of California [Irvine] (UCI), Mount Sinai Medical Center, Indiana State University, University of Alabama at Birmingham [ Birmingham] (UAB), University of Kentucky, New York University [New York] (NYU), NYU System (NYU), Department of Medical and Molecular Genetics, Department of Epidemiology and biostatistics, VU University Medical Center [Amsterdam], Emory University [Atlanta, GA], Department of Neurology, University of California-University of California-David Geffen School of Medicine [Los Angeles], Brigham & Women’s Hospital [Boston] (BWH), Harvard Medical School [Boston] (HMS), Department of Medical Genetics, HMNC Brain Health, Alzheimer Disease Research Laboratory, Harvard Medical School [Boston] (HMS)-Massachusetts General Hospital [Boston], Oregon Health and Science University [Portland] (OHSU), Cleveland Clinic, Laboratoire d'Informatique, Systèmes, Traitement de l'Information et de la Connaissance (LISTIC), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Department of Psychiatry, School of Medicine-Johns Hopkins University and Johns Hopkins Bayview Medical Center, Douglas Mental Health University Institute [Montréal], McGill University = Université McGill [Montréal, Canada], Department of neurosciences, University of California [San Diego] (UC San Diego), Department of Physics and Astronomy [Fort Worth], Texas Christian University (TCU), Department of Computer Science [University of California, Davis], Indiana University System, Institute for Aging and Alzheimer’s Disease Research [Fort Worth] (IAADR), Department of Laboratory Medicine and Pathology, Mayo Clinic, Institute for Memory Impairments and Neurological Disorders [Irvine], University of Colorado Anschutz [Aurora], Tanz Center Research in Neurodegenerative Diseases [Toronto], University of Toronto, Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Keck School of Medicine [Los Angeles], Indiana University [South Bend], Massachusetts General Hospital, Novartis Institutes for Biomedical Research [Cambridge, MA, USA], Departments of Pathology and Laboratory Medicine (Neuropathology) and Neurology, UCLA Medical Center-David Geffen School of Medicine [Los Angeles], University of California-University of California-University of California [Los Angeles] (UCLA), University of North Carolina [Chapel Hill] (UNC), University of North Carolina System (UNC), Institut de Génomique d'Evry (IG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, University of Antwerp (UA), Institute Born-Bunge, Karolinska Institutet [Stockholm], Karolinska University Hospital [Stockholm], University of Kuopio, Centre Mémoire de Ressources et de Recherche [Lille-Bailleul] (CMRR), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Hôpital Roger Salengro [Lille], Laboratoire d'Analyse Génomique, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Inserm-U1167, Dpt Gériatrie [CHU Broca], AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Neuroépidémiologie, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), Université Montpellier 1 (UM1)-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Alzheimer Precision Medicine [CHU Pitié-Salpétriêre] (GRC 21 AMP), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Department of Epidemiology, University of Washington, School of Medicine [Los Angeles], Albert Einstein College of Medicine [New York], IdiPAZ - Instituto de Investigación La Paz [Madrid, Spain], Instituto de Física Teórica UAM/CSIC (IFT), Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Department of Internal Medicine, University of Central Asturias [Oviedo, Spain], Human Genome Sequencing Center, Baylor College of Medicine, Baylor University-Baylor University, Department of Epidemiology, Erasmus Medical Centre, Translational Genomics Research Institute [Phoenix, AZ, USA], University of Arizona, Banner Alzheimer's Institute [Phoenix, AZ, États-Unis], University of Texas Health Science Center at San Antonio [San Antonio], Mount Sinai School of Medicine, Department of Psychiatry-Icahn School of Medicine at Mount Sinai [New York] (MSSM), Department. of Neurological Sciences, University of Milan, IRCCS Ospedale Maggiore Policlinico, Centre for Research in Neurodegenerative Diseases, VA Puget Sound Health Care System/GRECC [Seattle, WA, USA], University of Pisa - Università di Pisa, Pfizer Worldwide Research and Development [Cambridge, MA, USA], Università cattolica del Sacro Cuore [Piacenza e Cremona] (Unicatt), Texas Tech University Health Sciences Center, Texas Tech University [Lubbock] (TTU), Saarland University [Saarbrücken], University of Bonn, Department of Public Health and Primary Care, University of Cambridge [UK] (CAM), Cambridge Institute for Medical Research (CIMR), Department of Molecular Neurosciences, Institute of Neurology, UCL, Institute of Psychiatry, Institute of psychiatry, University of British Columbia (UBC), the Clinical Neuroscience Research Group, University of Manchester [Manchester]-Greater Manchester Neurosciences Centre, Aristotle University of Thessaloniki, Memory and Dementia Centre, 3rd Department of Neurology, G. Pa, University of Barcelona, University of Southampton, Department of Psychiatry [Oxford] (POWIC), University of Oxford [Oxford]-The Warneford Hospital, School of Psychology [Cardiff University], Department of Medical Sciences, UCL, Institute of Neurology [London], Washington University School of Medicine, Netherlands Genomics Initiative, Netherlands Consortium for Healthy Aging [Leiden, Netherlands] (NCHA), School of Medecine, Center for Translational and Computational Neuroimmunology [New York, NY, États-Unis] (CTCN), Department of Neurology [New York, NY, États-Unis], Columbia University Medical Center (CUMC), Columbia University [New York]-Columbia University [New York]-Columbia University Medical Center (CUMC), Columbia University [New York]-Columbia University [New York], School of Life Sciences, Department of Neuroscience, Mayo Clinic Jacksonville, Icelandic Heart Association, Heart Preventive Clinic and Research Institute, Klinik für Psychiatrie, Martin-Luther-University Halle-Wittenberg, Epidémiologie et Biostatistique [Bordeaux], Université Bordeaux Segalen - Bordeaux 2-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), The Center for Applied Genomics, Children’s Hospital of Philadelphia (CHOP ), Clínica Universidad de Navarra [Pamplona], Neurodegenerative Brain Diseases Group, VIB, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University-Medical Research Council, Brigham Young University (BYU), Institut de Santé Publique, d'Epidémiologie et de Développement (ISPED), Université Bordeaux Segalen - Bordeaux 2, The Gertrude H Sergivesky Center, Columbia University College of Physicians and Surgeons, Genetic Epidemiology Unit, Section of Clinical and Molecular Neurogenetics, Universität zu Lübeck [Lübeck], University of Pennsylvania - Department of Pathology & Laboratory Medecine, Framingham Heart Study [Framingham, MA, USA], ANR-10-IAHU-0006,IHU-A-ICM,Institut de Neurosciences Translationnelles de Paris(2010), European Project: 29845,LSH-ACC-MENTOR, University of Pennsylvania-University of Pennsylvania, Universität Bonn = University of Bonn-Institute of Human Genetics [Bonn, Germany], Universität Leipzig-Universität Leipzig, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), University of Pennsylvania, Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro (UNIBA), Università degli Studi di Perugia = University of Perugia (UNIPG), Universidad Autónoma de Madrid (UAM), Università degli studi di Parma = University of Parma (UNIPR), Institut de la Mémoire et de la Maladie d'Alzheimer [CHU Pitié-Salpétriêre] (IM2A), Université Pierre et Marie Curie - Paris 6 (UPMC)-CHU Pitié-Salpêtrière [AP-HP], Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 (TCDV), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Universität Leipzig, Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma] (Unicatt), Yeshiva University- Albert Einstein College of Medicine [New York], Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Gui de Chauliac [CHU Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université de Montpellier (UM), Università degli Studi di Milano = University of Milan (UNIMI), Saarland University Hospital (UKS), Università degli Studi di Firenze = University of Florence (UniFI), Universidade do Porto = University of Porto, University of California (UC)-University of California (UC), University of California [San Francisco] (UC San Francisco), University of California (UC), University of Kansas Medical Center [Kansas City, KS, USA], Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Centre de Biologie Intégrative (CBI), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), University of California [Irvine] (UC Irvine), University of Kentucky (UK), University of California (UC)-University of California (UC)-David Geffen School of Medicine [Los Angeles], Department of Computer Science [Univ California Davis] (CS - UC Davis), University of California (UC)-University of California (UC)-University of California [Los Angeles] (UCLA), Université Paris-Saclay-Institut de Biologie François JACOB (JACOB), Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Groupe de recherche clinique Alzheimer Precision Medicine (GRC 21 - APM), Sorbonne Université (SU), Universidad Autónoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), University of Texas Health Science Center at San Antonio [San Antonio, Tx, USA], Universität Bonn = University of Bonn, University of Oxford-The Warneford Hospital, Medical Research Council-Cardiff University, Universität zu Lübeck = University of Lübeck [Lübeck], Epidemiology, Neurology, Gastroenterology & Hepatology, Internal Medicine, Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement (Inserm U1167 - RID-AGE - Institut Pasteur), Génétique, Reproduction et Développement - Clermont Auvergne (GReD), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS), Eberhard Karls Universität Tübingen, IRCCS 'Casa Sollievo della Sofferenza', Centro de Investigación Biomédica en Red para Enfermedades Neurodegenerativas (Ciberned), University of Florida [Gainesville], University of Parma, Troubles cognitifs dégénératifs et vasculaires (U1171), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-INSERM, Yeshiva University- Albert Einstein College of Medicine, Institut d’Électronique, de Microélectronique et de Nanotechnologie (IEMN) - UMR 8520 (IEMN), Centre National de la Recherche Scientifique (CNRS)-Université de Lille-Université Polytechnique Hauts-de-France (UPHF)-Ecole Centrale de Lille-Université Polytechnique Hauts-de-France (UPHF)-Institut supérieur de l'électronique et du numérique (ISEN), Autonomous University of Barcelona (UAB), Università degli Studi di Firenze [Firenze], Universidade do Porto [Porto], Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Washington University in St Louis, University of South Florida (USF), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, McGill University, Charité - Universitätsmedizin Berlin / Charite - University Medicine Berlin, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [APHP]-Centre National de la Recherche Scientifique (CNRS), Neuropsychiatrie : recherche épidémiologique et clinique, Alzheimer Precision Medicine GRC n°21 (APM), CHU Pitié-Salpêtrière [APHP], Albert Einstein College of Medicine, Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Spain] (CSIC), Università Cattolica del S. Cuore - Catholic University of the Sacred Hearth, University of Florence (UNIFI), CIBER de Enfermedades Neurodegenerativas (CIBERNED), Universität zu Lübeck [Lübeck] - University of Lübeck [Lübeck], [ANR-10-IAIHU-06],« Investissements d'avenir » ,Agence nationale de la recherche (ANR), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-CHU Pitié-Salpêtrière [AP-HP], Icahn School of Medicine at Mount Sinai [New York] (MSSM)-Department of Psychiatry, van der Lee, Sven J [0000-0003-1606-8643], Naj, Adam C [0000-0002-9621-2942], Badarinarayan, Nandini [0000-0002-6944-748X], Chouraki, Vincent [0000-0002-4698-1794], Graham, Robert R [0000-0001-7151-4277], Hoffmann, Per [0000-0002-6573-983X], Smith, Albert V [0000-0003-1942-5845], Satizabal, Claudia L [0000-0002-1115-4430], Brody, Jennifer A [0000-0001-8509-148X], Wolters, Frank J [0000-0003-2226-4050], Lupton, Michelle K [0000-0002-7274-7299], Lin, Honghuang [0000-0003-3043-3942], Adams, Hieab H [0000-0003-3687-2508], Giedraitis, Vilmantas [0000-0003-3423-2021], Pasquier, Florence [0000-0001-9880-9788], Chen, Yuning [0000-0002-7358-7055], Bossù, Paola [0000-0002-1432-0078], Ghetti, Bernardino [0000-0002-1842-8019], Yang, Qiong [0000-0002-3658-1375], Aspelund, Thor [0000-0002-7998-5433], Bullido, María J [0000-0002-6477-1117], Rivadeneira, Fernando [0000-0001-9435-9441], Rubinsztein, David C [0000-0001-5002-5263], Al-Chalabi, Ammar [0000-0002-4924-7712], Tsolaki, Magda [0000-0002-2072-8010], De Jager, Philip L [0000-0002-8057-2505], Dickson, Dennis W [0000-0001-7189-7917], Van Broeckhoven, Christine [0000-0003-0183-7665], Ikram, M Arfan [0000-0003-0372-8585], Amouyel, Philippe [0000-0001-9088-234X], Lambert, Jean-Charles [0000-0003-0829-7817], Apollo - University of Cambridge Repository, Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Centre de Biologie Intégrative (CBI), Alzheimer Precision Medicine [CHU Pitié-Salpétriêre] (GRC 21 APM), Berr, Claudine, Institut de Neurosciences Translationnelles de Paris - - IHU-A-ICM2010 - ANR-10-IAHU-0006 - IAHU - VALID, and Mentoring of LifeSciHealth-Multipliers in the Accession Candidate Countries - LSH-ACC-MENTOR - 29845 - OLD
Subjects: 0301 basic medicine, Linkage disequilibrium, [SDV]Life Sciences [q-bio], Medizin, Sequence Homology, Genome-wide association study, genetics [Alzheimer Disease], metabolism [Microglia], Linkage Disequilibrium, 0302 clinical medicine, genetics [Protein Interaction Maps], genetics [Membrane Glycoproteins], Gene Frequency, Immunologic, genetics [Adaptor Proteins, Signal Transducing], Receptors, genetics [Exome], Odds Ratio, Innate, genetics [Receptors, Immunologic], Exome, Protein Interaction Maps, genetics [Genetic Predisposition to Disease], Receptors, Immunologic, ABI3 protein, human, Genetics, Adaptor Proteins, Signal Transducing, Alzheimer Disease, Amino Acid Sequence, Case-Control Studies, Gene Expression Profiling, Genetic Predisposition to Disease, Genotype, Humans, Immunity, Innate, Membrane Glycoproteins, Microglia, Phospholipase C gamma, Sequence Homology, Amino Acid, Polymorphism, Single Nucleotide, Adaptor Proteins, Single Nucleotide, 3. Good health, [SDV] Life Sciences [q-bio], Amino Acid, Settore MED/26 - NEUROLOGIA, genetics [Phospholipase C gamma], [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Alzheimer's disease, Common disease-common variant, Biology, Article, 03 medical and health sciences, ddc:570, medicine, Journal Article, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Polymorphism, Allele frequency, TREM2 protein, human, TREM2, Case-control study, Signal Transducing, Immunity, medicine.disease, R1, Minor allele frequency, genetics [Immunity, Innate], 030104 developmental biology, Human medicine, 030217 neurology & neurosurgery
Abstract: International audience; We identified rare coding variants associated with Alzheimer's disease in a three-stage case-control study of 85,133 subjects. In stage 1, we genotyped 34,174 samples using a whole-exome microarray. In stage 2, we tested associated variants (P < 1 × 10-4) in 35,962 independent samples using de novo genotyping and imputed genotypes. In stage 3, we used an additional 14,997 samples to test the most significant stage 2 associations (P < 5 × 10-8) using imputed genotypes. We observed three new genome-wide significant nonsynonymous variants associated with Alzheimer's disease: a protective variant in PLCG2 (rs72824905: p.Pro522Arg, P = 5.38 × 10-10, odds ratio (OR) = 0.68, minor allele frequency (MAF)cases = 0.0059, MAFcontrols = 0.0093), a risk variant in ABI3 (rs616338: p.Ser209Phe, P = 4.56 × 10-10, OR = 1.43, MAFcases = 0.011, MAFcontrols = 0.008), and a new genome-wide significant variant in TREM2 (rs143332484: p.Arg62His, P = 1.55 × 10-14, OR = 1.67, MAFcases = 0.0143, MAFcontrols = 0.0089), a known susceptibility gene for Alzheimer's disease. These protein-altering changes are in genes highly expressed in microglia and highlight an immune-related protein-protein interaction network enriched for previously identified risk genes in Alzheimer's disease. These genetic findings provide additional evidence that the microglia-mediated innate immune response contributes directly to the development of Alzheimer's disease.
Published: 2017

28. Speeded saccadic and manual visuo-motor decisions: Distinct processes but same principles

Author: Bompas, Aline, Hedge, Craig, Sumner, Petroc, Bompas, Aline, Cardiff University's Brain Research Imaging Centre [Cardiff] (CUBRIC), School of Psychology [Cardiff University], Cardiff University-Cardiff University, Brain Dynamics and Cognition (DYCOG), Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), This research was funded by the ESRC (ES/K002325/1)., Brain Dynamics and Cognition Team (U1028 Inserm - UMR5292 CNRS), Centre de recherche en neurosciences de Lyon (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Reaction time, Linguistics and Language, genetic structures, Action selection, Competition, [SDV]Life Sciences [q-bio], Decision Making, Models, Neurological, BF, Experimental and Cognitive Psychology, Models, Psychological, Q1, Article, Modelling, [SDV] Life Sciences [q-bio], Neuropsychology and Physiological Psychology, Response modalities, Artificial Intelligence, Developmental and Educational Psychology, Saccades, Humans, Neural Networks, Computer, Psychomotor Performance
Abstract: Highlights • Core architecture of visuo-motor selection model generalises across effectors. • Hand and eyes show very different response times, but similar decision times. • Longer non-decision time for visuo-manual responses accounts for longer response times. • Stronger faster transient visual inputs for saccades account for different selection dynamics., Action decisions are considered an emergent property of competitive response activations. As such, decision mechanisms are embedded in, and therefore may differ between, different response modalities. Despite this, the saccadic eye movement system is often promoted as a model for all decisions, especially in the fields of electrophysiology and modelling. Other research traditions predominantly use manual button presses, which have different response distribution profiles and are initiated by different brain areas. Here we tested whether core concepts of action selection models (decision and non-decision times, integration of automatic and selective inputs to threshold, interference across response options, noise, etc.) generalise from saccadic to manual domains. Using two diagnostic phenomena, the remote distractor effect (RDE) and ‘saccadic inhibition', we find that manual responses are also sensitive to the interference of visual distractors but to a lesser extent than saccades and during a shorter time window. A biologically-inspired model (DINASAUR, based on non-linear input dynamics) can account for both saccadic and manual response distributions and accuracy by simply adjusting the balance and relative timings of transient and sustained inputs, and increasing the mean and variance of non-decisional delays for manual responses. This is consistent with known neurophysiological and anatomical differences between saccadic and manual networks. Thus core decision principles appear to generalise across effectors, consistent with previous work, but we also conclude that key quantitative differences underlie apparent qualitative differences in the literature, such as effects being robustly reported in one modality and unreliable in another.
Published: 2017

29. Neurofeedback: One of today's techniques in psychiatry?

Author: M Le-Van-Quyen, François-Benoît Vialatte, Fabien Lotte, Diane Purper-Ouakil, Dominique Drapier, Renaud Jardri, Stéphanie Bioulac, Marco Congedo, J A Micoulaud-Franchi, Thomas Fovet, David M. A. Mehler, C. Daudet, Martijn Arns, J-M Batail, Utrecht University [Utrecht], Centre Hospitalier Guillaume Régnier [Rennes], Comportement et noyaux gris centraux = Behavior and Basal Ganglia [Rennes], CHU Pontchaillou [Rennes]-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université européenne de Bretagne - European University of Brittany (UEB)-Institut des Neurosciences Cliniques de Rennes (INCR), Sommeil, Attention et Neuropsychiatrie [Bordeaux] (SANPSY), Université de Bordeaux (UB)-CHU de Bordeaux Pellegrin [Bordeaux]-Centre National de la Recherche Scientifique (CNRS), GIPSA - Vision and Brain Signal Processing (GIPSA-VIBS), Département Images et Signal (GIPSA-DIS), Grenoble Images Parole Signal Automatique (GIPSA-lab ), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Grenoble Images Parole Signal Automatique (GIPSA-lab ), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Université de Bordeaux (UB), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193 (SCALab), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Bordelais de Recherche en Informatique (LaBRI), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure d'Électronique, Informatique et Radiocommunications de Bordeaux (ENSEIRB), Popular interaction with 3d content (Potioc), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure d'Électronique, Informatique et Radiocommunications de Bordeaux (ENSEIRB)-Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure d'Électronique, Informatique et Radiocommunications de Bordeaux (ENSEIRB)-Inria Bordeaux - Sud-Ouest, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), School of Psychology [Cardiff University], Cardiff University, University of Münster, Analyse Phenotypique, Developpementale et Genetique des Comportements Addictifs, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Diderot - Paris 7 (UPD7), Centre de Recherche Saint-Antoine (CR Saint-Antoine), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL), ANR-15-CE23-0013,REBEL,Redéfinir les Interfaces Cerveau-Ordinateur pour permettre à leurs utilisateurs d'en maitriser le contrôle(2015), Université de Rennes (UR)-Université européenne de Bretagne - European University of Brittany (UEB)-CHU Pontchaillou [Rennes]-Institut des Neurosciences Cliniques de Rennes = Institute of Clinical Neurosciences of Rennes (INCR), Sommeil, Addiction et Neuropsychiatrie [Bordeaux] (SANPSY), Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 (SCALab), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Université de Bordeaux (UB)-École Nationale Supérieure d'Électronique, Informatique et Radiocommunications de Bordeaux (ENSEIRB)-Centre National de la Recherche Scientifique (CNRS), Université de Bordeaux (UB)-École Nationale Supérieure d'Électronique, Informatique et Radiocommunications de Bordeaux (ENSEIRB)-Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB)-École Nationale Supérieure d'Électronique, Informatique et Radiocommunications de Bordeaux (ENSEIRB)-Centre National de la Recherche Scientifique (CNRS)-Inria Bordeaux - Sud-Ouest, Westfälische Wilhelms-Universität Münster = University of Münster (WWU), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche Saint-Antoine (CRSA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université européenne de Bretagne - European University of Brittany (UEB)-CHU Pontchaillou [Rennes]-Institut des Neurosciences Cliniques de Rennes (INCR)
Subjects: TREATING CHILDREN, Electroencephalography, 0302 clinical medicine, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, Troubles psychiatriques, EEG, [INFO.INFO-BT]Computer Science [cs]/Biotechnology, Psychiatry, Brain Mapping, medicine.diagnostic_test, RESOLUTION ELECTROMAGNETIC TOMOGRAPHY, ATTENTION-DEFICIT/HYPERACTIVITY DISORDER, Mental Disorders, 05 social sciences, fMRI, Brain, Cognition, REAL-TIME FMRI, Neurofeedback, Magnetic Resonance Imaging, 3. Good health, Neuropsychopharmacology, Psychiatry and Mental health, [SCCO.PSYC]Cognitive science/Psychology, Biological psychiatry, Psychology, medicine.medical_specialty, Psychotherapist, BRAIN-COMPUTER INTERFACES, SELECTIVE ATTENTION, 050105 experimental psychology, 03 medical and health sciences, Arts and Humanities (miscellaneous), [INFO.INFO-LG]Computer Science [cs]/Machine Learning [cs.LG], medicine, Humans, ADHD, 0501 psychology and cognitive sciences, Électroencéphalographie, Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7], EEG BIOFEEDBACK, Imagerie fonctionnelle par résonance magnétique en temps réel, Brain-computer interaction, [SCCO.NEUR]Cognitive science/Neuroscience, Psychiatric disorder, Evidence-based medicine, SENSORIMOTOR RHYTHM, ELECTROENCEPHALOGRAPHIC NEUROFEEDBACK, ANTERIOR CINGULATE, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, RC0321, Functional magnetic resonance imaging, Neurocognitive, 030217 neurology & neurosurgery
Abstract: International audience; ObjectivesNeurofeedback is a technique that aims to teach a subject to regulate a brain parameter measured by a technical interface to modulate his/her related brain and cognitive activities. However, the use of neurofeedback as a therapeutic tool for psychiatric disorders remains controversial. The aim of this review is to summarize and to comment the level of evidence of electroencephalogram (EEG) neurofeedback and real-time functional magnetic resonance imaging (fMRI) neurofeedback for therapeutic application in psychiatry.MethodLiterature on neurofeedback and mental disorders but also on Brain Computer Interfaces (BCI) used in the field of neurocognitive science has been considered by the group of expert of the NExT (Neurofeedback Evaluation & Training) section of the French Association of Biological Psychiatry and Neuropsychopharmacology (AFPBN).ResultsResults show a potential efficacy of EEG-neurofeedback in the treatment of attentional-deficit/hyperactivity disorder (ADHD) in children, even if this is still debated. For other mental disorders, there is too limited research to warrant the use of EEG-neurofeedback in clinical practice. Regarding fMRI-neurofeedback, the level of evidence remains too weak, for now, to justify clinical use. The literature review highlights various unclear points, such as indications (psychiatric disorders, pathophysiologic rationale), protocols (brain signals targeted, learning characteristics), and techniques (EEG, fMRI, signal processing). ConclusionThe field of neurofeedback involves psychiatrists, neurophysiologists and researchers in the field of brain-computer-interfaces. Future studies should determine the criteria for optimizing neurofeedback sessions. A better understanding of the learning processes underpinning neurofeedback could be a key element to develop the use of this technique in clinical practice.; IntroductionLe neurofeedback consiste à mesurer, chez un sujet, une activité cérébrale et à traiter le signal au moyen d’une interface technique afin d’en extraire un paramètre d’intérêt qui sera présenté en temps réel au participant sous la forme d’une information visuelle ou auditive. L’objectif est d’apprendre au sujet à modifier ce paramètre et donc à moduler son activité cérébrale et cognitive. Cependant, l’utilisation du neurofeedback en pratique clinique pour la prise en charge des troubles psychiatriques reste controversée.MéthodeCet article présente une synthèse de la 1re journée nationale sur le neurofeedback organisé par la section Neurofeedback Evaluation & Training (NExT) de l’Association française de psychiatrie biologique et de neuropharmacologie (AFPBN). Un état des lieux de l’utilisation du neurofeedback en électroencéphalographie (EEG) et en imagerie par résonance magnétique fonctionnelle (IRMf) est proposé. Pour intégrer l’arsenal thérapeutique, cette technique doit en effet répondre aux exigences de l’evidence based medicine.RésultatsLes études montrent une efficacité probable du neurofeedback en EEG pour le trouble du déficit de l’attention/hyperactivité (TDAH) chez les enfants. Pour les autres troubles psychiatriques, le nombre d’études est encore trop limité pour se positionner. En ce qui concerne le neurofeedback en IRMf, le niveau de preuve reste, pour l’heure, trop faible pour justifier une utilisation clinique. Les modalités d’emploi du neurofeedback, notamment en ce qui concerne les indications médicales, les protocoles d’utilisation (activité(s) cérébrale(s) ciblée(s), caractéristiques d’apprentissage) et les outils de mesure employés (EEG, IRMf, mode de traitement du signal) restent donc à clarifier.ConclusionLe vaste champ de recherche du neurofeedback implique à la fois des psychiatres, des neurophysiologistes et des chercheurs du domaine des interfaces cerveaux-ordinateurs. Les futurs travaux devront s’attacher à déterminer les critères permettant d’optimiser les séances de neurofeedback afin de mieux comprendre ses effets, le tout dans l’optique d’une utilisation en pratique clinique dans certaines indications. L’étude des processus d’apprentissage constitue un élément clé autour duquel les futures recherches devront se focaliser.
Published: 2017

30. Neurofeedback: One of today's techniques in psychiatry?

Author: Arns, Martijn, Batail, Jean-Marie, Bioulac, Stéphanie, Congedo, Marco, Daudet, Christophe, Drapier, Dominique, Fovet, Thomas, Jardri, Renaud, van Quyen, Le, Lotte, Fabien, Mehler, David, Micoulaud, Jean-Arthur, Purper-Ouakil, Diane, Vialatte, François Benoît, Lotte, Fabien, Interactions humain-machine, objets connectés, contenus numériques, données massives et connaissance - Redéfinir les Interfaces Cerveau-Ordinateur pour permettre à leurs utilisateurs d'en maitriser le contrôle - - REBEL2015 - ANR-15-CE23-0013 - AAPG2015 - VALID, Utrecht University [Utrecht], Centre Hospitalier Guillaume Régnier [Rennes], Comportement et noyaux gris centraux = Behavior and Basal Ganglia [Rennes], Université de Rennes (UR)-Université européenne de Bretagne - European University of Brittany (UEB)-CHU Pontchaillou [Rennes]-Institut des Neurosciences Cliniques de Rennes (INCR), Sommeil, Addiction et Neuropsychiatrie [Bordeaux] (SANPSY), Université de Bordeaux (UB)-CHU de Bordeaux Pellegrin [Bordeaux]-Centre National de la Recherche Scientifique (CNRS), GIPSA - Vision and Brain Signal Processing (GIPSA-VIBS), Département Images et Signal (GIPSA-DIS), Grenoble Images Parole Signal Automatique (GIPSA-lab ), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Grenoble Images Parole Signal Automatique (GIPSA-lab ), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Université de Bordeaux (UB), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 (SCALab), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Bordelais de Recherche en Informatique (LaBRI), Université de Bordeaux (UB)-École Nationale Supérieure d'Électronique, Informatique et Radiocommunications de Bordeaux (ENSEIRB)-Centre National de la Recherche Scientifique (CNRS), Popular interaction with 3d content (Potioc), Université de Bordeaux (UB)-École Nationale Supérieure d'Électronique, Informatique et Radiocommunications de Bordeaux (ENSEIRB)-Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB)-École Nationale Supérieure d'Électronique, Informatique et Radiocommunications de Bordeaux (ENSEIRB)-Centre National de la Recherche Scientifique (CNRS)-Inria Bordeaux - Sud-Ouest, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), School of Psychology [Cardiff University], Cardiff University, Westfälische Wilhelms-Universität Münster = University of Münster (WWU), Analyse Phenotypique, Developpementale et Genetique des Comportements Addictifs, Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche Saint-Antoine (CRSA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL), and ANR-15-CE23-0013,REBEL,Redéfinir les Interfaces Cerveau-Ordinateur pour permettre à leurs utilisateurs d'en maitriser le contrôle(2015)
Subjects: Imagerie fonctionnelle par résonance magnétique en temps réel, Brain-computer interaction, [INFO.INFO-TS] Computer Science [cs]/Signal and Image Processing, [SCCO.NEUR]Cognitive science/Neuroscience, fMRI, [SCCO.NEUR] Cognitive science/Neuroscience, [SDV.MHEP.PSM] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, [INFO.INFO-LG] Computer Science [cs]/Machine Learning [cs.LG], Neurofeedback, [INFO.INFO-BT] Computer Science [cs]/Biotechnology, [INFO.INFO-LG]Computer Science [cs]/Machine Learning [cs.LG], [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, [SCCO.PSYC] Cognitive science/Psychology, [SCCO.PSYC]Cognitive science/Psychology, ADHD, Troubles psychiatriques, EEG, [INFO.INFO-BT]Computer Science [cs]/Biotechnology, Électroencéphalographie
Abstract: ObjectivesNeurofeedback is a technique that aims to teach a subject to regulate a brain parameter measured by a technical interface to modulate his/her related brain and cognitive activities. However, the use of neurofeedback as a therapeutic tool for psychiatric disorders remains controversial. The aim of this review is to summarize and to comment the level of evidence of electroencephalogram (EEG) neurofeedback and real-time functional magnetic resonance imaging (fMRI) neurofeedback for therapeutic application in psychiatry.MethodLiterature on neurofeedback and mental disorders but also on Brain Computer Interfaces (BCI) used in the field of neurocognitive science has been considered by the group of expert of the NExT (Neurofeedback Evaluation & Training) section of the French Association of Biological Psychiatry and Neuropsychopharmacology (AFPBN).ResultsResults show a potential efficacy of EEG-neurofeedback in the treatment of attentional-deficit/hyperactivity disorder (ADHD) in children, even if this is still debated. For other mental disorders, there is too limited research to warrant the use of EEG-neurofeedback in clinical practice. Regarding fMRI-neurofeedback, the level of evidence remains too weak, for now, to justify clinical use. The literature review highlights various unclear points, such as indications (psychiatric disorders, pathophysiologic rationale), protocols (brain signals targeted, learning characteristics), and techniques (EEG, fMRI, signal processing). ConclusionThe field of neurofeedback involves psychiatrists, neurophysiologists and researchers in the field of brain-computer-interfaces. Future studies should determine the criteria for optimizing neurofeedback sessions. A better understanding of the learning processes underpinning neurofeedback could be a key element to develop the use of this technique in clinical practice., IntroductionLe neurofeedback consiste à mesurer, chez un sujet, une activité cérébrale et à traiter le signal au moyen d’une interface technique afin d’en extraire un paramètre d’intérêt qui sera présenté en temps réel au participant sous la forme d’une information visuelle ou auditive. L’objectif est d’apprendre au sujet à modifier ce paramètre et donc à moduler son activité cérébrale et cognitive. Cependant, l’utilisation du neurofeedback en pratique clinique pour la prise en charge des troubles psychiatriques reste controversée.MéthodeCet article présente une synthèse de la 1re journée nationale sur le neurofeedback organisé par la section Neurofeedback Evaluation & Training (NExT) de l’Association française de psychiatrie biologique et de neuropharmacologie (AFPBN). Un état des lieux de l’utilisation du neurofeedback en électroencéphalographie (EEG) et en imagerie par résonance magnétique fonctionnelle (IRMf) est proposé. Pour intégrer l’arsenal thérapeutique, cette technique doit en effet répondre aux exigences de l’evidence based medicine.RésultatsLes études montrent une efficacité probable du neurofeedback en EEG pour le trouble du déficit de l’attention/hyperactivité (TDAH) chez les enfants. Pour les autres troubles psychiatriques, le nombre d’études est encore trop limité pour se positionner. En ce qui concerne le neurofeedback en IRMf, le niveau de preuve reste, pour l’heure, trop faible pour justifier une utilisation clinique. Les modalités d’emploi du neurofeedback, notamment en ce qui concerne les indications médicales, les protocoles d’utilisation (activité(s) cérébrale(s) ciblée(s), caractéristiques d’apprentissage) et les outils de mesure employés (EEG, IRMf, mode de traitement du signal) restent donc à clarifier.ConclusionLe vaste champ de recherche du neurofeedback implique à la fois des psychiatres, des neurophysiologistes et des chercheurs du domaine des interfaces cerveaux-ordinateurs. Les futurs travaux devront s’attacher à déterminer les critères permettant d’optimiser les séances de neurofeedback afin de mieux comprendre ses effets, le tout dans l’optique d’une utilisation en pratique clinique dans certaines indications. L’étude des processus d’apprentissage constitue un élément clé autour duquel les futures recherches devront se focaliser.
Published: 2017

31. Reverberation limits the release from informational masking obtained in the harmonic and binaural domains

Author: Mathieu Lavandier, Vincent L. Gracco, John F. Culling, Mickael L. D. Deroche, School of Psychology [Cardiff University], Cardiff University, Laboratoire Génie Civil et Bâtiment (LGCB), École Nationale des Travaux Publics de l'État (ENTPE), School of Communication Sciences and Disorders, and McGill University = Université McGill [Montréal, Canada]
Subjects: Adult, Masking (art), Linguistics and Language, Reverberation, Speech perception, Speech recognition, BF, Experimental and Cognitive Psychology, 01 natural sciences, 050105 experimental psychology, Language and Linguistics, 0103 physical sciences, Humans, 0501 psychology and cognitive sciences, Psychoacoustics, Envelope (radar), 010301 acoustics, ComputingMilieux_MISCELLANEOUS, [SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], Communication, business.industry, 05 social sciences, Fundamental frequency, Sensory Systems, Speech Perception, Harmonic, business, Psychology, Perceptual Masking, Binaural recording
Abstract: A difference in fundamental frequency (ΔF0) and a difference in spatial location (ΔSL) are two cues known to provide masking releases when multiple speakers talk at once in a room. We examined situations in which reverberation should have no effect on the mechanisms underlying the releases from energetic masking produced by these two cues. Speech reception thresholds using both unpredictable target sentences and the coordinate response measure followed a similar pattern. Both ΔF0s and ΔSLs provided masking releases in the presence of nonspeech maskers (matched in excitation pattern and temporal envelope to the speech maskers) that, as intended, were robust to reverberation. Larger masking releases were obtained for speech maskers, but critically, they were affected by reverberation. These results suggest that reverberation either limits the amount of informational masking that is present to begin with or affects its release by ΔF0s or ΔSLs.
Published: 2017

32. Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss

Author: Kevin Drenner, Jérôme Sinniger, Mélanie Jambeau, Oliver Sendscheid, Anke Witting, Jelena Scekic-Zahirovic, Tatyana A. Shelkovnikova, Marie-Christine Birling, Albert C. Ludolph, Erik Storkebaum, Sina Mersmann, Caroline Rouaux, Clotilde Lagier-Tourenne, Marina Wagner, Stéphane Dieterlé, Luc Dupuis, Xiang-Dong Fu, Hajer El Oussini, Ying Sun, Hairi Li, Friedemann Kiefer, Yu Zhou, Jinsong Qiu, Sylvie Dirrig-Grosch, Mécanismes Centraux et Périphériques de la Neurodégénérescence, Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Max Planck Institute for Molecular Biomedicine, Max-Planck-Gesellschaft, University of California [San Diego] (UC San Diego), University of California, Institut Clinique de la Souris (ICS), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), School of Psychology [Cardiff University], Cardiff University, University of Ulm (UUlm), Ludwig Institute for Cancer Research, Dieterle, Stéphane, and University of California (UC)
Subjects: 0301 basic medicine, Cytoplasm, amyotrophic lateral sclerosis, PY‐NLS, motor neuron degeneration, [SDV]Life Sciences [q-bio], Mutant, Inbred C57BL, frontotemporal dementia, Medical and Health Sciences, Transgenic, MESH: Spinal Cord, MESH: Heart Conduction System, [SCCO]Cognitive science, Mice, 0302 clinical medicine, Gene expression, News & Views, MESH: Animals, MESH: Xenopus, Amyotrophic lateral sclerosis, Genetics, Motor Neurons, MESH: Middle Aged, MESH: RNA-Binding Protein FUS, General Neuroscience, Neurodegeneration, Brain, Biological Sciences, Cell biology, [SDV] Life Sciences [q-bio], medicine.anatomical_structure, Spinal Cord, MESH: HEK293 Cells, Knockout mouse, MESH: Nucleotide Motifs, MESH: Motor Neurons, MESH: Mutation, MESH: Myotonic Dystrophy, MESH: Mice, Transgenic, Mice, Transgenic, Biology, PY-NLS, General Biochemistry, Genetics and Molecular Biology, MESH: Sodium Channels, 03 medical and health sciences, MESH: Brain, MESH: Mice, Inbred C57BL, Information and Computing Sciences, medicine, Animals, Molecular Biology, Loss function, FUS, MESH: Humans, MESH: Molecular Sequence Data, General Immunology and Microbiology, MESH: Cytoplasm, MESH: NAV1.5 Voltage-Gated Sodium Channel, [SCCO] Cognitive science, Motor neuron, medicine.disease, MESH: Male, Mice, Inbred C57BL, 030104 developmental biology, MESH: RNA-Binding Proteins, Mutation, RC0321, RNA-Binding Protein FUS, MESH: Exons, MESH: Female, 030217 neurology & neurosurgery, Developmental Biology
Abstract: International audience; FUS is an RNA-binding protein involved in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Cytoplasmic FUS-containing aggregates are often associated with concomitant loss of nuclear FUS Whether loss of nuclear FUS function, gain of a cytoplasmic function, or a combination of both lead to neurodegeneration remains elusive. To address this question, we generated knockin mice expressing mislocalized cytoplasmic FUS and complete FUS knockout mice. Both mouse models display similar perinatal lethality with respiratory insufficiency, reduced body weight and length, and largely similar alterations in gene expression and mRNA splicing patterns, indicating that mislocalized FUS results in loss of its normal function. However, FUS knockin mice, but not FUS knockout mice, display reduced motor neuron numbers at birth, associated with enhanced motor neuron apoptosis, which can be rescued by cell-specific CRE-mediated expression of wild-type FUS within motor neurons. Together, our findings indicate that cytoplasmic FUS mislocalization not only leads to nuclear loss of function, but also triggers motor neuron death through a toxic gain of function within motor neurons.
Published: 2016

33. Effets sensori-moteurs et fonctionnels à long terme d’un traitement hebdomadaire par adaptation prismatique dans la négligence

Author: Rode, Gilles, Lacour, S., Jacquin-Courtois, Sophie, Pisella, L., Michel, Carine, Revol, P., Luauté, Jacques, Halligan, P., Pélisson, D., Rossetti, Y., Médecine Physique et Réadaptation [Hôpital Henry Gabrielle - Lyon], Hôpital Henry Gabrielle [CHU - HCL], Hospices Civils de Lyon ( HCL ) -Hospices Civils de Lyon ( HCL ), Centre de recherche en neurosciences de Lyon ( CRNL ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] ( UJM ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Plate-forme Mouvement et handicap [Hôpital Henry Gabrielle - Lyon], Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] ( CAPS ), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), School of Psychology [Cardiff University], Cardiff University, Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Centre de recherche en neurosciences de Lyon (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] (CAPS), and Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: Réhabilitation, [ SDV.NEU ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Adaptation prismatique, Négligence spatiale, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Abstract: International audience; La négligence spatiale (NS) constitue un facteur de mauvais pronostic fonctionnel. L’adaptation à une déviation prismatique de la vision vers la droite améliore la NS. Les bases neurophysiologiques et les modalités optimales de l’adaptation prismatique (AP) restent à valider. Cette étude vise à explorer les effets sensori-moteurs, cognitifs et fonctionnels à long terme produits par une séance d’AP hebdomadaire pendant 4 semaines. Un essai monocentrique, en double insu, randomisé et contrôlé a été réalisé. Vingt patients avec NS gauche secondaire à un accident vasculaire cérébral droit ont été inclus (10 dans le groupe « prisme » et 10 dans le groupe « témoin »). Les effets sensori-moteurs de l’AP ont été évalués par des mesures des droit-devant manuel et visuel, et par la précision du pointage sans rétroaction visuelle avant et après chaque séance d’AP. La mesure de l’indépendance fonctionnelle (MIF) était évaluée avant et 1, 3 et 6 mois après AP, la sévérité de la NS par l’échelle Behavioural Inattention Test (BIT) avant et 6 mois après AP. Au terme des 6 mois de suivi, les deux groupes montraient une amélioration similaire, corrélée à l’évolution du droit-devant visuel, marqueur de l’évolution des patients. Une séance d’AP hebdomadaire pendant 4 semaines s’avère une posologie insuffisante pour produire un bénéfice fonctionnel à long terme. Avant intervention, seul le droit-devant manuel constituait une mesure sensori-motrice reproductible. Pendant l’exposition prismatique, un questionnaire a montré qu’aucun patient n’a perçu les effets directs de la déviation optique sur le déroulement du geste de pointage. Les effets consécutifs sensori-moteurs produits par ce régime d’AP ont favorisé la réduction plus rapide du droit-devant manuel vers la gauche, suivie secondairement par le droit-devant visuel, ce qui permet d’éclairer les mécanismes d’action de l’AP sur la NS.
Published: 2015

34. IFPA Meeting 2011 workshop report III: Placental immunology; epigenetic and microRNA-dependent gene regulation; comparative placentation; trophoblast differentiation; stem cells

Author: Bill Kalionis, Peter Parham, Carolyn J.P. Jones, B.A. Croy, G. P. Collet, Anna Maria Nuzzo, Ornella Parolini, A.M. de Mestre, J. Ducray, J. C. Moreira De Mello, Lawrence W. Chamley, Ashley Moffett, Thaddeus G. Golos, Tamara Tilburgs, Alexander E. P. Heazell, Yoel Sadovsky, William E. Ackerman, Edward B. Chuong, SJ Coleman, Allen C. Enders, Judith N. Bulmer, S. Haider, Rosalind M. John, Aline R. Lorenzon, Guillaume Pidoux, Hiroaki Soma, Margaret G. Petroff, Aldo Rolfo, Olivia J. Holland, Anthony M. Carter, Julia König, Martha Patricia Ramírez-Pinilla, Gendie E. Lash, Berthold Huppertz, Wendy P. Robinson, Norah M. E. Fogarty, C.-P. Chen, Anne Husebekk, Guro M. Johnsen, J. R. Chaillet, Hayley Dickinson, Martin Gauster, J Southcombe, Ohio State University [Columbus] (OSU), Newcastle University [Newcastle], University of Southern Denmark (SDU), University of Pittsburgh School of Medicine, Pennsylvania Commonwealth System of Higher Education (PCSHE), University of Auckland [Auckland], Mackay Memorial Hospital, Stanford University, University of Manchester [Manchester], University of Oxford, Queen's University [Kingston, Canada], Royal Veterinary College [London], University of London [London], Monash University [Melbourne], Durban University of Technology, University of California [Davis] (UC Davis), University of California (UC), University of Cambridge [UK] (CAM), Karl-Franzens-Universität Graz, University of Wisconsin-Madison, Medizinische Universität Wien = Medical University of Vienna, University Hospital of North Norway [Tromsø] (UNN), School of Psychology [Cardiff University], Cardiff University, Oslo University Hospital [Oslo], Centre for Molecular Medicine Norway, Nordic EMBL Partnership, University of Oslo (UiO)-Oslo University Hospital [Oslo], University of Melbourne, The Royal Women's Hospital, Universidade de São Paulo = University of São Paulo (USP), Instituto de Biociências, Universidade de São Paulo, Università degli studi di Torino = University of Turin (UNITO), Stanford School of Medicine [Stanford], Stanford Medicine, Stanford University-Stanford University, Centro di Ricerca E.Menni, Fondazione Poliambulanza, Department of Mathematics (University of Kansas), University of Kansas [Lawrence] (KU), La grossesse normale et pathologique: développement et fonctions du placenta et de l'utérus (UMR_S 767), Institut des sciences du Médicament -Toxicologie - Chimie - Environnement (IFR71), Institut de Recherche pour le Développement (IRD)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Universidad Industrial de Santander [Bucaramanga] (UIS), University of British Columbia (UBC), Saitama Medical School, Harvard University, University of Oxford [Oxford], University of California, Karl-Franzens-Universität [Graz, Autriche], University of São Paulo (USP), University of Turin, Institut National de la Santé et de la Recherche Médicale (INSERM)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Paris Descartes - Paris 5 (UPD5)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Harvard University [Cambridge], and Pidoux, Guillaume
Subjects: Cellular differentiation, [SDV]Life Sciences [q-bio], education, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Biology, Article, 03 medical and health sciences, 0302 clinical medicine, microRNA, medicine, Settore BIO/13 - BIOLOGIA APPLICATA, Epigenetics, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, [SDV.BDLR] Life Sciences [q-bio]/Reproductive Biology, 030304 developmental biology, Epigenesis, Regulation of gene expression, 0303 health sciences, 030219 obstetrics & reproductive medicine, Obstetrics and Gynecology, Trophoblast, Placentation, [SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology, [SDV] Life Sciences [q-bio], medicine.anatomical_structure, Animals, Biomedical Research, Cell Differentiation, Epigenesis, Genetic, Female, Fetal Proteins, Gene Expression Regulation, Developmental, Humans, Immunomodulation, Male, MicroRNAs, Physiology, Comparative, Placenta, Pregnancy, Pregnancy Proteins, Stem Cell Transplantation, Stem Cells, Trophoblasts, Health Status, Reproductive Medicine, Immunology, Stem cell, Developmental Biology
Abstract: International audience; Workshops are an important part of the IFPA annual meeting as they allow for discussion ofspecialised topics. At IFPA meeting 2011 there were twelve themed workshops, five of which aresummarized in this report. These workshops related to various aspects of placental biology: 1)immunology; 2) epigenetics; 3) comparative placentation; 4) trophoblast differentiation; 5) stemcells.
Published: 2012

35. Dissociation in Hysteria and Hypnosis: Evidence from Cognitive Neuroscience

Author: Quinton Deeley, David A. Oakley, Peter W. Halligan, Vaughan Bell, Institute of Psychiatry, King's College London, Division of Psychology and Language Sciences, University College London, School of Psychology [Cardiff University], and Cardiff University
Subjects: FUNCTIONAL IMAGING, Hypnosis, medicine.drug_class, Models, Neurological, Psychogenic amnesia, Dissociative Disorders, Cognitive neuroscience, Dissociative, 050105 experimental psychology, NEUROPSYCHOLOGY, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Paralysis, 0501 psychology and cognitive sciences, Dissociative disorders, Conversion disorder, BRAIN MAPPING, Tomography, Emission-Computed, Single-Photon, NEUROPSYCHIATRY, 05 social sciences, Neuropsychology, Brain, medicine.disease, Magnetic Resonance Imaging, Psychiatry and Mental health, HYSTERIA, Positron-Emission Tomography, Surgery, Amnesia, Neurology (clinical), Psychology, Neurocognitive, 030217 neurology & neurosurgery, Clinical psychology
Abstract: International audience; Jean-Martin Charcot proposed the radical hypothesis that similar brain processes were responsible for the unexplained neurological symptoms of 'hysteria', now typically diagnosed as 'conversion disorder' or 'dissociative (conversion) disorder', and the temporary effects of hypnosis. While this idea has been largely ignored, recent cognitive neuroscience studies indicate that (i) hypnotisability traits are associated with a tendency to develop dissociative symptoms in the sensorimotor domain; (ii) that dissociative symptoms can be modelled with suggestions in highly hypnotisable subjects; and that (iii) hypnotic phenomena engage brain processes similar to those seen in patients with symptoms hysteria. One clear theme to emerge from the findings is that 'symptom' presentation, whether clinically diagnosed or simulated using hypnosis, is associated with increases in prefrontal cortex activity suggesting that intervention by the executive system in both automatic and voluntary cognitive processing is common to both hysteria and hypnosis. Nevertheless, while the recent literature provides some compelling leads into the understanding of these phenomena, the field still lacks well-controlled systematically designed studies to give a clear insight into the neurocognitive processes underlying dissociation in both hysteria and hypnosis. We hope this review provides an agenda for future research.
Published: 2010

36. Lesions to the ventral, but not the dorsal, medial prefrontal cortex enhance latent inhibition

Author: Josephine E. Haddon, David N. George, Helen H. J. Pothuizen, Anaïs M. Duffaud, Simon Killcross, School of Psychology [Cardiff University], Cardiff University, Psychoneuroimmunologie, nutrition et génétique, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), and University of New South Wales [Sydney] (UNSW)
Subjects: Conditioned emotional response, Dorsum, Male, Photomicrography, Reinforcement Schedule, Infralimbic cortex, Conditioning, Classical, Emotions, Prefrontal Cortex, CONDITIONAL EMOTIONAL RESPONSE, INFRALIMBIC CORTEX, Stimulus (physiology), Neuropsychological Tests, 03 medical and health sciences, 0302 clinical medicine, Latent inhibition, medicine, Animals, SCHIZOPHRÉNIE, Reinforcement, Prefrontal cortex, 030304 developmental biology, INTERFERENCE, 0303 health sciences, PERSISTENT LATENT INHIBITION, General Neuroscience, Cognition, HISTOLOGIE, PRELIMBIC CORTEX, Rats, Inhibition, Psychological, medicine.anatomical_structure, RAT, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Psychology, Neuroscience, Reinforcement, Psychology, 030217 neurology & neurosurgery, Cognitive psychology
Abstract: International audience; The acquisition of a conditioned response to a stimulus when it is paired with a reinforcer is retarded if the stimulus has previously been repeatedly pre-exposed in the absence of the reinforcer. This effect, called latent inhibition, has previously been found to be insensitive to lesions of the medial prefrontal cortex (mPFC) in rats. Using an on-baseline conditioned emotional response procedure, which is especially sensitive to small variations in the absolute magnitude of latent inhibition, we found increased latent inhibition following excitotoxic lesions of the mPFC (Experiment 1) or the ventral mPFC alone (Experiment 2) as compared with sham-operated control rats. Lesions restricted to the dorsal mPFC, however, were without effect (Experiment 2). These results are consistent with those of experiments employing another type of interference procedure, extinction. Together, these findings suggest that when different contingencies between a stimulus and a reinforcer are established in separate learning phases, lesions to the ventral mPFC result in increased interference between first-learned and second-learned contingencies. As a consequence, retrieval of the second-learned contingency is impaired, and performance is dominated by the first-learned contingency. These findings are discussed in light of the use of latent inhibition to model cognitive deficits in schizophrenia.
Published: 2010

37. Cocktail-parties dans les salles : de la psychophysique aux cartes dintelligibilité

Author: Lavandier, Mathieu, Culling, John, Jelfs, Sam, Leclere, Quentin, Société Française d'Acoustique - SFA, Département génie civil et batiment (ENTPE) (DGCB), École Nationale des Travaux Publics de l'État (ENTPE)-Centre National de la Recherche Scientifique (CNRS), School of Psychology [Cardiff University], Cardiff University, and Welsh School of Architecture
Subjects: [SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], intelligibilité, [SPI.ACOU] Engineering Sciences [physics]/Acoustics [physics.class-ph], perception binaurale, cocktail-party, [PHYS.MECA.ACOU] Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], acoustique des salles, [PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph]
Abstract: National audience; Les méthodes actuelles de prédiction de lintelligibilité dans les salles sont monaurales. Elles permettent de prédire lintelligibilité dune voix seule en présence dun bruit de fond, mais ne sont pas conçues pour traiter le cas de sources masquantes localisées telles que des voix dans une cocktail-party ou des bureaux en open space, ou une fenêtre ouverte sur du bruit urbain. Pour améliorer lintelligibilité, le système binaural est capable de séparer des sources concurrentes situées à des positions différentes (démasquage spatial), mais cette faculté est sensible à la réverbération. A partir dun modèle de perception binaurale dans le bruit, une méthode de prédiction de lintelligibilité a été développée. Cette méthode prédit les phénomènes de démasquage spatial et linfluence de la coloration due à la salle, à partir de mesures de réponses impulsionnelles binaurales de la salle. La prédiction est valable lorsque la parole est en champ proche et pour un nombre quelconque de sources masquantes de bruit continu. Elle a été validée lors de tests découte impliquant différentes salles (modélisées et réelles), différentes configurations sources-auditeur (distances et azimuts), et jusquà trois sources masquantes simultanées. La corrélation entre mesure et prédiction a toujours été supérieure à 0,95. La méthode est suffisamment efficace pour générer des cartes dintelligibilité à partir de réponses impulsionnelles, et pourra être intégrée aux logiciels de design architectural afin de prédire lintelligibilité à partir de plans.
Published: 2010

38. Prediction of binaural speech intelligibility against noise in rooms

Author: Mathieu Lavandier, John F. Culling, École Nationale des Travaux Publics de l'État (ENTPE), École Nationale des Travaux Publics de l'État (ENTPE)-Ministère de l'Ecologie, du Développement Durable, des Transports et du Logement, Laboratoire Génie Civil et Bâtiment (LGCB), School of Psychology [Cardiff University], Cardiff University, and Ministère de l'Ecologie, du Développement Durable, des Transports et du Logement-École Nationale des Travaux Publics de l'État (ENTPE)
Subjects: Sound localization, Reverberation, Time Factors, business.product_category, Acoustics and Ultrasonics, Computer science, Acoustics, BF, Monaural, Intelligibility (communication), 01 natural sciences, Background noise, 03 medical and health sciences, 0302 clinical medicine, Architectural acoustics, Arts and Humanities (miscellaneous), Architecture, 0103 physical sciences, Humans, Speech, 030223 otorhinolaryngology, 010301 acoustics, Headphones, ComputingMilieux_MISCELLANEOUS, [SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], Analysis of Variance, Auditory Threshold, Ear, Models, Theoretical, Noise, Acoustic Stimulation, Speech Perception, business, Binaural recording, Psychoacoustics
Abstract: In the presence of competing speech or noise, reverberation degrades speech intelligibility not only by its direct effect on the target but also by affecting the interferer. Two experiments were designed to validate a method for predicting the loss of intelligibility associated with this latter effect. Speech reception thresholds were measured under headphones, using spatially separated target sentences and speech-shaped noise interferers simulated in virtual rooms. To investigate the effect of reverberation on the interferer unambiguously, the target was always anechoic. The interferer was placed in rooms with different sizes and absorptions, and at different distances and azimuths from the listener. The interaural coherence of the interferer did not fully predict the effect of reverberation. The azimuth separation of the sources and the coloration introduced by the room also had to be taken into account. The binaural effects were modeled by computing the binaural masking level differences in the studied configurations, the monaural effects were predicted from the excitation pattern of the noises, and speech intelligibility index weightings were applied to both. These parameters were all calculated from the room impulse responses convolved with noise. A 0.95-0.97 correlation was obtained between the speech reception thresholds and their predicted value.
Published: 2010

39. Referees' Decision Making about Transgressions: The Influence of Player Gender at the Highest National Level

Author: Gregory R. Maio, Fabrice Dosseville, Olivier Rascle, Nicolas Souchon, Genevieve Cabagno, Alan Traclet, Centre de Recherche sur le Sport et le Mouvement (CeRSM), Université Paris Nanterre (UPN), Violences, Innovations, Politiques, Socialisations et Sports (VIPS2), Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Le Mans Université (UM)-École normale supérieure - Rennes (ENS Rennes), Institute of Sport Sciences of University of Lausanne (ISSUL), Centre d'étude sport et actions motrices (CesamS), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU), Information, Organisation et Action (IOA), School of Psychology [Cardiff University], Cardiff University, Centre de Recherche sur l'Education, les apprentissages et la didactique (CREAD EA 3875), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université de Brest (UBO)-Institut Brestois des Sciences de l'Homme et de la Société (IBSHS), Université de Brest (UBO), Université de Lausanne (UNIL), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Université de Rouen Normandie (UNIROUEN), Mobilités : Vieillissement, Pathologie, Santé (COMETE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Caen Normandie (UNICAEN), Université de Brest (UBO)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut Brestois des Sciences de l'Homme et de la Société (IBSHS), and Université de Lausanne = University of Lausanne (UNIL)
Subjects: Aggression, Gender relations, 05 social sciences, [SHS.PSY]Humanities and Social Sciences/Psychology, 050109 social psychology, 030229 sport sciences, 16. Peace & justice, [SHS]Humanities and Social Sciences, Gender Studies, 03 medical and health sciences, 0302 clinical medicine, Arts and Humanities (miscellaneous), Developmental and Educational Psychology, Gender bias, medicine, 0501 psychology and cognitive sciences, National level, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, medicine.symptom, Objectivity (science), Psychology, Social psychology, General Psychology, ComputingMilieux_MISCELLANEOUS
Abstract: Affiliation EA 4260 - Intitulé actuel : Centre d’Etude des Stratégies et des Actions Motrices et Sportives (CESAMS) mais entre 2008 et 2011 autre intitulé : Information Organisation et Action (IOA).; International audience; Prior research has found that referees are harsher toward sporting offenses in regional-level matches between women than in regional-level matches between men. We tested whether this bias also occurs at a higher, national level of competition, despite the greater pressures for objectivity and fairness at this level. Referees' decisions were examined in 15 national-level handball matches between women and 15 national-level handball matches between men after transgressions that varied in severity. The results suggest that referees made harsher decisions in female than in male matches. Although more research is needed, this study supported the hypothesis that referees may use the gender of players as a powerful judgmental heuristic for deciding how to respond to aggression.
Published: 2009

40. Speech segregation in rooms: Monaural, binaural, and interacting effects of reverberation on target and interferer

Author: Mattieu N. Lavandier, John F. Culling, École Nationale des Travaux Publics de l'État (ENTPE), Ministère de l'Ecologie, du Développement Durable, des Transports et du Logement-École Nationale des Travaux Publics de l'État (ENTPE), Laboratoire Génie Civil et Bâtiment (LGCB), School of Psychology [Cardiff University], Cardiff University, and École Nationale des Travaux Publics de l'État (ENTPE)-Ministère de l'Ecologie, du Développement Durable, des Transports et du Logement
Subjects: Sound localization, Reverberation, business.product_category, Speech perception, Acoustics and Ultrasonics, Computer science, Acoustics, Monaural, Intelligibility (communication), 01 natural sciences, Speech Reception Threshold Test, 03 medical and health sciences, User-Computer Interface, 0302 clinical medicine, Architectural acoustics, Arts and Humanities (miscellaneous), 0103 physical sciences, Architecture, medicine, Auditory system, Humans, Active listening, 030223 otorhinolaryngology, 010301 acoustics, Headphones, ComputingMilieux_MISCELLANEOUS, [SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], Auditory Threshold, Speech processing, medicine.anatomical_structure, Speech Perception, business, Noise, Binaural recording
Abstract: Speech reception thresholds were measured in virtual rooms to investigate the influence of reverberation on speech intelligibility for spatially separated targets and interferers. The measurements were realized under headphones, using target sentences and noise or two-voice interferers. The room simulation allowed variation of the absorption coefficient of the room surfaces independently for target and interferer. The direct-to-reverberant ratio and interaural coherence of sources were also varied independently by considering binaural and diotic listening. The main effect of reverberation on the interferer was binaural and mediated by the coherence, in agreement with binaural unmasking theories. It appeared at lower reverberation levels than the effect of reverberation on the target, which was mainly monaural and associated with the direct-to-reverberant ratio, and could be explained by the loss of amplitude modulation in the reverberant speech signals. This effect was slightly smaller when listening binaurally. Reverberation might also be responsible for a disruption of the mechanism by which the auditory system exploits fundamental frequency differences to segregate competing voices, and a disruption of the “listening in the gaps” associated with speech interferers. These disruptions may explain an interaction observed between the effects of reverberation on the targets and two-voice interferers.
Published: 2008

41. Speech segregation in rooms: Effects of reverberation on both target and interferer

Author: Mathieu Lavandier, John F. Culling, École Nationale des Travaux Publics de l'État (ENTPE), Ministère de l'Ecologie, du Développement Durable, des Transports et du Logement-École Nationale des Travaux Publics de l'État (ENTPE), Laboratoire Génie Civil et Bâtiment (LGCB), School of Psychology [Cardiff University], Cardiff University, and École Nationale des Travaux Publics de l'État (ENTPE)-Ministère de l'Ecologie, du Développement Durable, des Transports et du Logement
Subjects: Reverberation, business.product_category, Acoustics and Ultrasonics, Acoustics, Intelligibility (communication), Environment, 01 natural sciences, 03 medical and health sciences, 0302 clinical medicine, Architectural acoustics, Arts and Humanities (miscellaneous), 0103 physical sciences, Humans, Speech, Attention, Psychoacoustics, Sound Localization, 030223 otorhinolaryngology, 010301 acoustics, Headphones, ComputingMilieux_MISCELLANEOUS, Physics, [SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], Hearing Tests, Auditory Threshold, Room acoustics, Azimuth, Acoustic Stimulation, business, Binaural recording, Perceptual Masking
Abstract: Speech reception thresholds were measured to investigate the influence of a room on speech segregation between a spatially separated target and interferer. The listening tests were realized under headphones. A room simulation allowed selected positioning of the interferer and target, as well as varying the absorption coefficient of the room internal surfaces. The measurements involved target sentences and speech-shaped noise or 2-voice interferers. Four experiments revealed that speech segregation in rooms was not only dependent on the azimuth separation of sound sources, but also on their direct-to-reverberant energy ratio at the listening position. This parameter was varied for interferer and target independently. Speech intelligibility decreased as the direct-to-reverberant ratio of sources was degraded by sound reflections in the room. The influence of the direct-to-reverberant ratio of the interferer was in agreement with binaural unmasking theories, through its effect on interaural coherence. The effect on the target occurred at higher levels of reverberation and was explained by the intrinsic degradation of speech intelligibility in reverberation.
Published: 2007

42. Moving engagement 'upstream'? Nanotechnologies and the Royal Society and Royal Academy of Engineering's inquiry

Author: Nicholas Frank Pidgeon, Tee Rogers-Hayden, Center for Nanotechnology in Society (CNSI), University of California [Santa Barbara] (UCSB), University of California-University of California, School of Psychology [Cardiff University], and Cardiff University
Subjects: Public awareness of science, business.industry, Communication, 05 social sciences, Stakeholder, Public debate, 050801 communication & media studies, Public relations, 050905 science studies, 0508 media and communications, Framing (social sciences), Arts and Humanities (miscellaneous), Developmental and Educational Psychology, Sociology, Social Sciences & Humanities, 0509 other social sciences, Public engagement, business
Abstract: In response to the impetus that is gathering in the UK for upstream public engagement, we analyze the impacts of the Royal Society and Royal Academy of Engineering report of 2004 on Nanoscience and Nanotechnologies: Opportunities and Uncertainties. The paper presents an analysis of 24 interviews with stakeholders to the nanotechnology debate. It uses these to discuss the inquiry process and the recommendations contained within the report, as well as to explore and critique the notion of “upstream.” We find broad support for the inquiry, which was positioned by many stakeholders itself as upstream, primarily because of its broad framing and wide stakeholder involvement. A number of both explicit and implicit upstream elements are also contained within its recommendations. However, the interviews also suggest that the notion of upstream engagement is a contested concept with a range of associated dilemmas and tensions. In drawing out some of the promise and perils of moving public debate upstream, the paper concludes that there is a risk of merely replacing the perceived deficit in public understanding of science with a perceived deficit in public engagement with science.
Published: 2007

43. Functional anatomy of the therapeutic effects of prism adaptation on left neglect

Author: Luauté, J, Michel, C., Rode, G., Pisella, Laure, Jacquin-Courtois, S., Costes, N., Cotton, F., Le Bars, D., Boisson, D., Halligan, P., Rossetti, Y., Luauté, J., Pisella, L., Centre de Recherche et d'Application en Traitement de l'Image et du Signal (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-École Supérieure Chimie Physique Électronique de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Littoral, Environnement, Télédétection, Géomatique (LETG - Caen), Littoral, Environnement, Télédétection, Géomatique UMR 6554 (LETG), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Université d'Angers (UA)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Brest (UBO)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Géographie et d'Aménagement Régional de l'Université de Nantes (IGARUN), Université de Nantes (UN)-Université de Nantes (UN)-Université de Caen Normandie (UNICAEN), Université de Nantes (UN)-Université de Nantes (UN), Université de Lyon, Hôpital Henry Gabrielle [CHU - HCL], Hospices Civils de Lyon (HCL), Centre d'Etude et de Recherche Multimodal Et Pluridisciplinaire en imagerie du vivant (CERMEP - imagerie du vivant), Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-CHU Saint-Etienne-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), RMN et optique : De la mesure au biomarqueur, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École Supérieure Chimie Physique Électronique de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), School of Psychology [Cardiff University], Cardiff University, Centre de recherche en neurosciences de Lyon (CRNL), and Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Male, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, Brain mapping, 0302 clinical medicine, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, Cortex (anatomy), media_common, Lenses, Temporal cortex, Aged, 80 and over, Brain Mapping, 05 social sciences, Stroke Rehabilitation, Brain, Adaptation, Physiological, [PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], Stroke, medicine.anatomical_structure, Treatment Outcome, Cerebral blood flow, Cerebrovascular Circulation, [INFO.INFO-TI]Computer Science [cs]/Image Processing [eess.IV], [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Female, [SDV.IB]Life Sciences [q-bio]/Bioengineering, Psychology, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, media_common.quotation_subject, education, Posterior parietal cortex, [SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine, 050105 experimental psychology, Neglect, Perceptual Disorders, 03 medical and health sciences, medicine, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, Humans, 0501 psychology and cognitive sciences, Aged, [SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], Recovery of Function, Functional imaging, Positron-Emission Tomography, Neurology (clinical), Prism adaptation, Neuroscience, 030217 neurology & neurosurgery, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: Objective: To investigate the anatomic substrates underlying the beneficial effect of prism adaptation in five patients with persistent left neglect following right stroke. Methods: In a functional imaging PET study, we used a covariation analysis to examine linear changes of regional cerebral blood flow over sessions as a function of left neglect improvement. Results: The network of significant brain regions associated with improvement of left neglect performance produced by prism adaptation involved the right cerebellum, the left thalamus, the left temporo-occipital cortex, the left medial temporal cortex, and the right posterior parietal cortex. Conclusion: Our results suggest that the realignment of visuomotor coordinates is processed by the cerebellum and that low level sensorimotor adaptation actively modulates cerebral areas, albeit now relying on intact cerebellocerebral connections. Hence, our data support the hypothesis that the beneficial effect of prism adaptation on the clinical presentation of left neglect derives from modulation of cortical regions implicated in spatial cognition.
Published: 2006

44. Salivary testosterone and aggression, delinquency, and social dominance in a population-based longitudinal study of adolescent males

Author: Stephanie Helena Maria Van Goozen, Jean-Marc Assaad, Daniel S. Nagin, Frank Vitaro, Louise Arseneault, Herman van Engeland, Benoist Schaal, Richard E. Tremblay, Jean R. Séguin, Irene van Bokhoven, Department of Child and Adolescent Psychiatry (UMCU), UMCU, School of Psychology [Cardiff University], Cardiff University, Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Centre National de la Recherche Scientifique (CNRS)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB), Social, genetic and developmental psychiatry research center Institute of Psychiatry, Queen Mary University of London (QMUL), Research Unit on Children's Psycho-Social Maladjustement, Université de Montréal (UdeM), H.J. Heinz III School of Public Policy and Management, Carnegie Mellon University [Pittsburgh] (CMU), Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS), School of Psychology, Université de Montréal [Montréal], Department of Child and Adolescent Psychiatry ( UMCU ), Centre des Sciences du Goût et de l'Alimentation [Dijon] ( CSGA ), Institut National de la Recherche Agronomique ( INRA ) -Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique ( CNRS ), Queen Mary University of London ( QMUL ), Université de Montréal, and Carnegie Mellon University [Pittsburgh] ( CMU )
Subjects: Adult, Male, Longitudinal study, Adolescent, medicine.drug_class, Psychology, Adolescent, Poison control, Developmental psychology, 03 medical and health sciences, Behavioral Neuroscience, 0302 clinical medicine, Endocrinology, Pubertal development, Reference Values, Injury prevention, medicine, Juvenile delinquency, Humans, 0501 psychology and cognitive sciences, Testosterone, Longitudinal Studies, Child, Saliva, Dominance, Analysis of Variance, Delinquency, Chi-Square Distribution, Endocrine and Autonomic Systems, Aggression, [SCCO.NEUR]Cognitive science/Neuroscience, Puberty, 05 social sciences, Testosterone (patch), Androgen, Dominance (ethology), Social Dominance, Adolescent Behavior, Child, Preschool, Population Surveillance, [ SCCO.NEUR ] Cognitive science/Neuroscience, Juvenile Delinquency, Regression Analysis, medicine.symptom, Psychology, 030217 neurology & neurosurgery, 050104 developmental & child psychology, Demography
Abstract: Testosterone (T) has been found to have a stimulating effect on aggressive behavior in a wide range of vertebrate species. There is also some evidence of a positive relationship in humans, albeit less consistently. In the present study we investigated the relationship between T and aggression, dominance and delinquency over time, covering a period from early adolescence to adulthood. From a large population-based sample (n = 1.161) a subgroup of 96 boys was selected whose behavior had been assessed repeatedly by different informants from age 12 to 21 years, and who had provided multiple T samples over these years of assessment. On the whole, a decrease in aggressive and delinquent behavior was observed in a period in which T rises dramatically. Boys who developed a criminal record, had higher T levels at age 16. In addition, positive associations were observed between T and proactive and reactive aggression and self-reported delinquent behavior. Over the pubertal years different forms of aggressive and delinquent behavior were positively related to T, which may indicate that specific positive links are dependent on the social setting in which this relationship is assessed.
Published: 2006

45. Decoding the auditory nerve to simulate sensorineural pathologies and help refine their diagnosis

Author: Grange, Jacques, Culling, John, Espaces, Nature et Culture (ENeC), Université Paris-Sorbonne (UP4)-Centre National de la Recherche Scientifique (CNRS), School of Psychology [Cardiff University], and Cardiff University
Subjects: [PHYS.MECA.VIBR]Physics [physics]/Mechanics [physics]/Vibrations [physics.class-ph], psychophysics, otorhinolaryngologic diseases, BF, RF, hearing loss simulation, pathology discrimination, RB, QP, sensorineural pathologies, [PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph]
Abstract: International audience; Pathologies underlying sensorineural hearing loss (SNHL) cannot yet be differentially diagnosed. We are developing means of pathology discrimination with an advanced SNHL simulator. The physiologically inspired model of the auditory periphery (MAP, Meddis et al., 1986~2018) simulates stimulus encoding at the auditory nerve (AN) level. Such encoding is then decoded/converted back to an acoustic signal to be presented to young, normally hearing listeners. For a speech-in-noise intelligibility task employing stimuli processed through the normal-hearing model, speech reception thresholds (SRTs) were just 1-2 dB higher than those obtained for unprocessed stimuli. By inserting a specific pathology in the model, we believe one can reveal the psychophysical signature of that pathology. A first study demonstrated the importance of efferent reflexes to the faithful coding of the temporal modulations that carry speech information. With both efferent reflexes knocked out, SRTs grew by 3-4 dB. Simulated AN rate-level functions illustrate how efferent reflexes enable the AN dynamic-range adaptation to context level that prevents information loss. A second study measured the impact of simulated pathologies on SRTs. While deactivating 70% of ANs or halving the endocochlear potential did not lead to any appreciable SRT inflation, total loss of outer haircells led to a significantly smaller SRT inflation than the 3-4 dB found when efferent reflexes were knocked out. A third study measured SRT elevation with growing deafferentiation. ~90% deafferentiation was found to be required to reflect performance found in hearing impaired listeners, an outcome consistent with the stochastic under-sampling predicted by Lopez-Poveda and Barrios (2013). A final study established changes in binaural masking level difference (BMLD) for the pathologies simulated in the second study. Comparing N0S0 to N0Spi thresholds of audibility of a 250 Hz tone in white noise, a significant BMLD drop was found for all simulated pathologies.

46. Risk of Suicide and Suicidality in Patients with Moderate to Severe Psoriasis: results from the British Association of Dermatologists Biologic and Immunomodulators Register (BADBIR).

Author: Williams K, Lada G, Reynolds NJ, Mcelhone K, Evans I, Warren RB, Walton S, Hughes O, Bewley A, Mason K, and Kleyn CE
Abstract: Background: Psoriasis is associated with poor mental health and reduced quality of life. Although the high risk for depression in patients with psoriasis is well-established, their suicidality risk is uncertain. Previous studies provide contrasting results and have not included patients with clinically-confirmed severe disease., Objectives: Our aim was to determine risk of suicide among patients with moderate to severe psoriasis compared with the general population, and investigate if psychiatric comorbidity or history of suicidality increases future suicidality risk in psoriasis. We further estimated the incidence of suicidal and self-injurious behaviours in patients., Methods: Analysis was performed using the British Association of Dermatologists Biologics and Immunomodulators Register (BADBIR). As controls, general population mortality and suicide data were used., Results: There were 9 suicides in BADBIR. The incidence rate of suicide was 12.5 per 100,000 person-years (95% CI 6.53, 24.11) in BADBIR versus 11.0 per 100,000 person-years (95% CI 10.7, 11.3) in the general population in England and Wales. Among patients, psychiatric comorbidity or past suicidality was associated with higher risk for suicidal ideation, suicide attempts and self-injurious behaviours., Conclusions: Suicide rates among patients with moderate to severe psoriasis were not significantly higher compared with the general population. Suicide is a rare event and our results are limited by the uncertainty in the estimate reliability. However, considering the high depression prevalence in psoriasis, our findings support the need for prompt assessment of patients for psychiatric comorbidities and suicidality history. Further research is required on suicidal behaviours and the role of psoriasis severity., (© The Author(s) 2024. Published by Oxford University Press on behalf of British Association of Dermatologists.)
Published: 2024
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47. The who, when, and why of pacifier use.

Author: Mitev K, Frewin KL, Augustinova M, Niedenthal PM, Rychlowska M, and Vanderwert RE
Abstract: Background: Social and familial consequences of pacifier use remain poorly understood. The present study attempts to shed more light on the characteristics of parents using pacifiers with their infants and to explore how pacifier use affects perceptions of infant emotionality, maternal stress, and parental efficacy., Methods: The study sample consisted of 428 mothers (range: 17-49 years) of infants (0-36 months) who completed a comprehensive questionnaire assessing infant and parent characteristics as well as parenting practices and pacifier use. We compared attitudes toward pacifiers, parenting stress, children's levels of reactivity and self-regulation, and maternal efficacy among Pacifier Users, Never-Users, and families that Tried-Pacifiers., Results: The reported results reveal benefits of pacifier use for the family relationships, namely reduced parenting stress (p = 0.018), better parent-child dynamics (p < 0.001), and more positive perceptions of child's affectivity (p = 0.006), which are all important aspects of infant development., Conclusion: Our findings highlight developmental benefits of pacifier use, a practice that is known to have both positive and negative long-term consequences for healthy child development. It is, therefore, important for health professionals to have discussions about the pros and cons of pacifier use with parents., Impact: The study provides novel insights into how and why mothers use pacifiers and into the psychological consequences of this practice. We found pacifier use is associated with less maternal stress, better mother-child dynamics, and more positive perceptions of child's affectivity. Our findings document developmental benefits of pacifier use adding a new perspective to the debate on pacifiers. Doctors, health visitors, pediatric nurses, and midwives may consider this evidence when advising parents on pacifier use., (© 2024. The Author(s).)
Published: 2024
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48. Effect of ambisonic order on spatial release from masking.

Author: Culling JF, Akrofi AO, and Dighton SR
Abstract: In two experiments, spatial release from masking (SRM) was measured using an ambisonic reproduction system for a range of different ambisonic orders. The first experiment used ambisonic panning while the second experiment used impulse responses recorded from a sixth-order ambisonic microphone. Both experiments found a progressive increase in SRM with increasing ambisonic order for speech presented against a single speech-shaped-noise interferer. SRM increased progressively up to at least fourth order and continued to asymptotically improve at higher-ambisonic orders toward the level achieved with point sources. The second experiment found that this effect was robust for different acoustic environments., (© 2024 Author(s). All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).)
Published: 2024
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49. Developmental differences in canonical cortical networks: Insights from microstructure-informed tractography.

Author: Genc S, Schiavi S, Chamberland M, Tax CMW, Raven EP, Daducci A, and Jones DK
Abstract: In response to a growing interest in refining brain connectivity assessments, this study focuses on integrating white matter fiber-specific microstructural properties into structural connectomes. Spanning ages 8-19 years in a developmental sample, it explores age-related patterns of microstructure-informed network properties at both local and global scales. First, the diffusion-weighted signal fraction associated with each tractography-reconstructed streamline was constructed. Subsequently, the convex optimization modeling for microstructure-informed tractography (COMMIT) approach was employed to generate microstructure-informed connectomes from diffusion MRI data. To complete the investigation, network characteristics within eight functionally defined networks (visual, somatomotor, dorsal attention, ventral attention, limbic, fronto-parietal, default mode, and subcortical networks) were evaluated. The findings underscore a consistent increase in global efficiency across child and adolescent development within the visual, somatomotor, and default mode networks ( p < 0.005). Additionally, mean strength exhibits an upward trend in the somatomotor and visual networks ( p < 0.001). Notably, nodes within the dorsal and ventral visual pathways manifest substantial age-dependent changes in local efficiency, aligning with existing evidence of extended maturation in these pathways. The outcomes strongly support the notion of a prolonged developmental trajectory for visual association cortices. This study contributes valuable insights into the nuanced dynamics of microstructure-informed brain connectivity throughout different developmental stages., Competing Interests: Competing Interests: The authors have declared that no competing interests exist., (© 2024 Massachusetts Institute of Technology.)
Published: 2024
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50. Comparison of embryologist stress, somatization, and burnout reported by embryologists working in UK HFEA-licensed ART/IVF clinics and USA ART/IVF clinics.

Author: Murphy A, Lapczynski MS, Proctor G Jr, Glynn TR, Domar AD, Gameiro S, Palmer GA, and Collins MG
Subjects: Adult, Female, Humans, Male, Middle Aged, Cross-Sectional Studies, Embryology, Prevalence, Surveys and Questionnaires, United Kingdom epidemiology, United States epidemiology, Burnout, Professional epidemiology, Burnout, Professional psychology, Occupational Stress epidemiology, Occupational Stress psychology, Somatoform Disorders epidemiology, Somatoform Disorders psychology
Abstract: Study Question: What is the prevalence of occupational stress, somatization, and burnout reported by UK and US, embryologists and the impact of work conditions on these well-being outcomes?, Summary Answer: Surveyed UK and US embryologists reported moderate perceived stress, low somatic symptom severity, high levels of burnout, and overall stressful work conditions, but with differences that could be due to country-specific occupational and employment characteristics., What Is Known Already?: Spanish, UK, US, and international surveys have identified high levels of occupational stress, somatization, burnout, and occupational health issues among embryologists. These issues have been attributed to embryologists' occupational challenges and work conditions., Study Design, Size, Duration: A cross-sectional web-based survey was sent to 253 embryologists working in UK ART/IVF clinics and 487 embryologists working in US ART/IVF clinics., Participants/materials, Setting, Methods: Participants self-reported their stress levels, somatization, burnout, and work conditions. Proportions across the Perceived Stress Scale (PSS), Patient Health Questionnaire (PHQ-15), Maslach Burnout Inventory-General Survey (MBI-GS), a single-item work unit grade (A-F), and customized occupational and sociodemographic questionnaires were calculated using descriptive statistics. Welch's t-test was utilized to compare PSS and PHQ-15 scores between groups. Risk ratios were calculated using log-binomial regression for all models except for levels of anxiety related to performing cryostorage tasks, for which Poisson models were used., Main Results and the Role of Chance: In total, 50.6% (128) of the embryologists in the UK and 50.1% (244) in the US completed the survey. Both groups self-reported moderate PSS and low PHQ-15 scores, although fewer UK embryologists scored high on the MBI cynicism dimension than their US colleagues (43% UK vs 60% US embryologists, P < 0.05). The UK and US embryologists did not differ on the MBI exhaustion dimension with both scoring high for exhaustion (59% UK vs 62% US). Although 81% and 80% of UK and US embryologists, respectively, reported working overtime, more embryologists in the UK reported being adequately compensated. Increasing levels of anxiety-related to cryostorage showed a dose-dependent increased risk of burnout on at least two MBI-GS dimensions only in the UK group, and, a dose-dependent likelihood of higher PSS and PHQ-15 scores in both groups., Limitations, Reasons for Caution: Since the two groups were surveyed 9 months apart and were self-reporting, the study is limited by the differences in responsibilities, scheduling, and workload specific to the time of year., Wider Implications of the Findings: Work-related health issues and occupational challenges shared by UK and US embryologists could be addressed by organizational enhancements and technology. Lower levels of stress and burnout among UK embryologists might be due to the HFEA-provided structure/certainty., Study Funding/competing Interest(s): This study was supported without any external funding by TMRW Life Sciences Inc., which is developing and commercializing an automated platform for embryology. M.G.C. and M.S.L. are full-time employees and stockholders/shareholders with TMRW Life Sciences, and A.M. of Novavax, Inc. was an employee of TMRW Life Sciences. G.P. is a consultant for TMRW Life Sciences. The remaining authors declare no conflict of interest., Trial Registration Number: NCT05326802; NCT05708963., (© The Author(s) 2024. Published by Oxford University Press on behalf of European Society of Human Reproduction and Embryology.)
Published: 2024
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