411 results on '"Schroder K"'
Search Results
2. Carrington cycle 24: The solar chromospheric emission in a historical and stellar perspective
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Schroder, K. -P., Mittag, M., Schmitt, J. H. M. M., Jack, D., Hempelmann, A., and Gonzalez-Perez, J. N.
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Astrophysics - Solar and Stellar Astrophysics - Abstract
We present the solar S-index record of cycle 24, obtained by the TIGRE robotic telescope facility and its high-resolution spectrograph HEROS (R$\approx$20,000), which measures the solar chromospheric Ca II H&K line emission by using moonlight. Our calibration process uses the same set of standard stars as introduced by the Mt. Wilson team, thus giving us a direct comparison with their huge body of observations taken between 1966 and 1992, as well as with other cool stars. Carrington cycle 24 activity started from the unusually deep and long minimum 2008/09, with an S-index average of only 0.154, by 0.015 deeper than the one of 1986 (
=0.169). In this respect,the chromospheric radiative losses differ remarkably from the variation of the coronal radio flux F10.7cm and the sunspot numbers. In addition, the cycle 24 S-amplitude remained small, 0.022 (cycles 21 and 22 averaged: 0.024), and so resulted a very low 2014 maximum of=0.176 (cycles 21 and 22 averaged: 0.193). We argue that this find is significant, since the Ca II H&K line emission is a good proxy for the solar far-UV flux, which plays an important role in the heating of the Earth's stratosphere, and we further argue that the solar far-UV flux changes change s with solar activity much more strongly than the total solar output., Comment: 8 pages, 12 figure, accepted by MNRAS- Published
- 2017
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3. Time series of high resolution spectra of SN 2014J observed with the TIGRE telescope
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Jack, D., Mittag, M., Schroder, K. -P., Schmitt, J. H. M. M., Hempelmann, A., Gonzalez-Perez, J. N., Trinidad, M. A., Rauw, G., and Sixto, J. M. Cabrera
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Solar and Stellar Astrophysics - Abstract
We present a time series of high resolution spectra of the Type Ia supernova 2014J, which exploded in the nearby galaxy M82. The spectra were obtained with the HEROS echelle spectrograph installed at the 1.2 m TIGRE telescope. We present a series of 33 spectra with a resolution of R = 20, 000, which covers the important bright phases in the evolution of SN 2014J during the period from January 24 to April 1 of 2014. The spectral evolution of SN 2014J is derived empirically. The expansion velocities of the Si II P-Cygni features were measured and show the expected decreasing behaviour, beginning with a high velocity of 14,000 km/s on January 24. The Ca II infrared triplet feature shows a high velocity component with expansion velocities of > 20, 000 km/s during the early evolution apart from the normal component showing similar velocities as Si II. Further broad P-Cygni profiles are exhibited by the principal lines of Ca II, Mg II and Fe II. The TIGRE SN 2014J spectra also resolve several very sharp Na I D doublet absorption components. Our analysis suggests interesting substructures in the interstellar medium of the host galaxy M82, as well as in our Milky Way, confirming other work on this SN. We were able to identify the interstellar absorption of M82 in the lines of Ca II H & K at 3933 and 3968 A as well as K I at 7664 and 7698 A. Furthermore, we confirm several Diffuse Interstellar Bands, at wavelengths of 6196, 6283, 6376, 6379 and 6613 A and give their measured equivalent widths., Comment: 11 pages, 10 figures, accepted for publication in MNRAS
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- 2015
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4. Deletion of NADPH oxidase 2 in chondrocytes exacerbates ethanol‐mediated growth plate disruption in mice without major effects on bone architecture or gene expression
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Pedersen, K., primary, Watt, J., additional, Maimone, C., additional, Hang, H., additional, Denys, A., additional, Schroder, K., additional, Suva, L. J., additional, Chen, J.‐R., additional, and Ronis, M. J. J., additional
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- 2023
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5. Revisiting the cycle-rotation connection for late-type stars
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Mittag, M., primary, Schmitt, J.H.M.M., additional, and Schroder, K.-P., additional
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- 2023
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6. NetImmerse - Evaluating User Experience in Immersive Network Exploration
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Schroder, K., Kohl, S., Ajdadilish, B., Duffy, Vincent G., Marketing & Supply Chain Management, and RS: GSBE other - not theme-related research
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Immersive analytics ,Network visualization ,Virtual reality - Abstract
The increasing amount of interconnected data has given rise to a need among researchers and practitioners to develop new approaches to visualizing network structures. The intricacy of such structures vastly exceeds the capacity of most conventional approaches to network visualization in terms of dimensional and resolution restrictions, as they are mostly presented as two-dimensional with on a limited size screen. An additional limitation of traditional network visualization tools from a human-computer interaction standpoint is the limited interaction itself where immersion and "deep-diving" into high-dimensional data is not possible. We built NetImmerse, an application to visualize network data in a virtual environment with the ability to overview, zoom, and request details on-demand. Within the virtual space, users can either walk around the 3D data representation or rotate and move the representation using the two controllers. We tested the application with users and simulated a representative use case. NetImmerse enabled the participants to gain accurate insights based on the defined task. Participants indicated a PU of 5.25 and a PEOU of 5.46. We believe that NetImmerse is an engaging platform for multi-dimensional data exploration and may result in better insights and enhanced network data exploration.
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- 2022
7. Metabolic gene expression changes in astrocytes in Multiple Sclerosis cerebral cortex are indicative of immune-mediated signaling
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Zeis, T., Allaman, I., Gentner, M., Schroder, K., Tschopp, J., Magistretti, P.J., and Schaeren-Wiemers, N.
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- 2015
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8. NLRC5 deficiency impairs MHC class I-dependent lymphocyte killing by cytotoxic T cells: W08.002
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Guarda, G., Staehli, F., Ludigs, K., Heinz, L., Seguín-Estévez, Q., Ferrero, I., Braun, M., Schroder, K., Rebsamen, M., Tardivel, A., Mattmann, C., MacDonald, H. R., Romero, P., Reith, W., and Tschopp, J.
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- 2012
9. P516Leptin improves vascular function by inducing vascular expression of neuronal nitric oxidase synthase (nNOS)
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Schroder, K., Benkhoff, S., Shimokawa, H., Grisk, O., and Brandes, R.P.
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- 2012
10. Physically touching and tasting virtual objects enhances the realism of virtual experiences
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Hoffman, H. G., Hollander, A., Schroder, K., Rousseau, S., and Furness, III, T.
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- 1998
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11. 40 Expression and function of Schlafen-4 in macrophage biology and inflammation
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van Zuijlen, Wendy J.M., Schroder, K., Garceau, V., Sweet, M. J., Kellie, S., and Hume, D. A.
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- 2008
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12. Phase locking of CO2 lasers by the use of diffraction effects
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Schroder, K., Muller, A., and Schuocker, D.
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Phase-locked loops -- Research ,Carbon dioxide lasers -- Research ,Diffraction -- Usage ,Astronomy ,Physics - Abstract
A technique to phase lock C[O.sub.2] lasers with spatially separated active media was investigated. Only reflective optics (except for the output coupler) were used, in view of applications of this method in the field of high-power lasers. Phase locking was established when the beams of two resonator branches were made to propagate very close to each other along the so-called coupling path. As a result of diffraction effects both resonators were exchanging energy, establishing a phase-locked operation mode when several locking conditions were fulfilled. A maximum coupling coefficient (the ratio between the diffracted intensity in the second cavity and the intercavity intensity in the first resonator) of 2.6% could be achieved. Because phase locking was highly dependent on the difference between the two resonator lengths, a length control that uses a piezoelectric translator connected to one of the resonator mirrors was used. To detect phase locking, the intensity maximum of the interference pattern of the two laser beams was monitored with a fast detector. By application of a ramp signal to the piezoelectric translator and detection of the peak intensity, the locking range could be measured. Up to a mismatch of the resonator lengths of [Lambda]/130, locking could be maintained. The measurements were compared with results of a computer simulation with Huygens-Fresnel integrals to describe diffraction and the one-dimensional Maxwellian equations to calculate supermodes and to analyze their stability. The numerical results showed an excellent agreement with the measured values.
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- 1995
13. Chemical micropatterning of polymeric cell culture substrates using low-pressure hydrogen gas discharge plasmas
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Ohl, A., Schroder, K., Keller, D., Meyer-Plath, A., Bienert, H., Husen, B., and Rune, G. M.
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- 1999
14. Unilateral pulmonary oedema complicating supine bicycle exercise echocardiography
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VOLLER, H, DOVIFAT, C, and SCHRODER, K
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- 1999
15. Significance of initial ST segment changes for thrombolytic treatment in first inferior myocardial infarction
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Schroder, K, Wegscheider, K, Neuhaus, K-L, Tebbe, U, and Schroder, R
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- 1997
16. RNA-sequencing analysis of biopsies from chronic liver disease patients identifies gene signatures associated with progressive liver disease
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Ramnath, D., primary, Irvine, K., additional, Lukowski, S., additional, Horsfall, L., additional, Loh, K., additional, Clouston, A., additional, Patel, P., additional, Iyer, A., additional, Lampe, G., additional, Stow, J., additional, Schroder, K., additional, Fairlie, D., additional, Powell, J., additional, Powell, E., additional, and Sweet, M., additional
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- 2018
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17. Salmonella employs multiple mechanisms to subvert the TLR-inducible zinc-mediated antimicrobial response of human macrophages
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Kapetanovic, R, Bokil, NJ, Achard, MES, Ong, CLY, Peters, KM, Stocks, CJ, Phan, MD, Monteleone, M, Schroder, K, Irvine, KM, Saunders, BM, Walker, MJ, Stacey, KJ, McEwan, AG, Schembri, MA, and Sweet, MJ
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Salmonella typhimurium ,Biochemistry & Molecular Biology ,Macrophages ,Cytoplasmic Vesicles ,Toll-Like Receptors ,Gene Expression Regulation, Bacterial ,Cell Line ,Zinc ,RNA, Bacterial ,Bacterial Proteins ,Salmonella ,bacteria ,RNA, Messenger ,Cells, Cultured ,Copper - Abstract
© FASEB. We aimed to characterize antimicrobial zinc trafficking within macrophages and to determine whether the professional intramacrophage pathogen Salmonella enterica serovar Typhimurium (S. Typhimurium) subverts this pathway. Using both Escherichia coli and S. Typhimurium, we show that TLR signaling promotes the accumulation of vesicular zinc within primary human macrophages. Vesicular zinc is delivered to E. coli to promote microbial clearance, whereas S. Typhimurium evades this response via Salmonella pathogenicity island (SPI)-1. Even in the absence of SPI-1 and the zinc exporter ZntA, S. Typhimurium resists the innate immune zinc stress response, implying the existence of additional host subversion mechanisms. We also demonstrate the combinatorial antimicrobial effects of zinc and copper, a pathway that S. Typhimurium again evades. Our use of complementary tools and approaches, including confocal microscopy, direct assessment of intramacrophage bacterial zinc stress responses, specific E. coli and S. Typhimurium mutants, and inductively coupled plasma mass spectroscopy, has enabled carefully controlled characterization of this novel innate immune antimicrobial pathway. In summary, our study provides new insights at the cellular level into the well-documented effects of zinc in promoting host defense against infectious disease, as well as the complex host subversion strategies employed by S. Typhimurium to combat this pathway.
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- 2016
18. Differential expression of NLRP3 among hematopoietic cells
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Guarda G Zenger M Yazdi AS Schroder K Ferrero I Menu P Tardivel A Mattmann C Tschopp J
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integumentary system - Abstract
Although the importance of the NOD like receptor family pyrin domain containing 3 (NLRP3) inflammasome in health and disease is well appreciated a precise characterization of NLRP3 expression is yet undetermined. To this purpose we generated a knock in mouse in which the Nlrp3 coding sequence was substituted for the GFP (enhanced GFP [egfp]) gene. In this way the expression of eGFP is driven by the endogenous regulatory elements of the Nlrp3 gene. In this study we show that eGFP expression indeed mirrors that of NLRP3. Interestingly splenic neutrophils macrophages and in particular monocytes and conventional dendritic cells showed robust eGFP fluorescence whereas lymphoid subsets eosinophils and plasmacytoid dendritic cells showed negligible eGFP levels. NLRP3 expression was highly inducible in macrophages both by MyD88 and Trif dependent pathways. In vivo when mice were challenged with diverse inflammatory stimuli differences in both the number of eGFP expressing cells and fluorescence intensity were observed in the draining lymph node. Thus NLRP3 levels at the site of adaptive response initiation are controlled by recruitment of NLRP3 expressing cells and by NLRP3 induction.
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- 2011
19. Process control of large-scale finite element simulation software
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Spence, P.A., primary, Weingarten, L.I., additional, Schroder, K., additional, Tung, D.M., additional, and Sheaffer, D.A., additional
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- 1996
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20. [BP.10.02] NOX4 DEFICIENCY LEADS TO HYPERTENSION AND VASCULAR-RENAL FIBROSIS WITH ENHANCED EFFECTS IN ANG II-DEPENDENT HYPERTENSION
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Lacchini, S., primary, Harvey, A., additional, Lopes, R., additional, Montezano, A.C., additional, Rios, F., additional, Schroder, K., additional, Brandes, R.P., additional, and Touyz, R.M., additional
- Published
- 2017
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21. The Effect of Fluoroethylene Carbonate as an Additive on the Solid Electrolyte Interphase on Silicon Lithium-Ion Electrodes
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Schroder, K, Alvarado, J, Yersak, TA, Li, J, Dudney, N, Webb, LJ, Meng, YS, and Stevenson, KJ
- Abstract
© 2015 American Chemical Society.Fluoroethylene carbonate (FEC) has become a standard electrolyte additive for use with silicon negative electrodes, but how FEC affects solid electrolyte interphase (SEI) formation on the silicon anode's surface is still not well understood. Herein, SEI formed from LiPF6-based carbonate electrolytes, with and without FEC, were investigated on 50 nm thick amorphous silicon thin film electrodes to understand the role of FEC on silicon electrode surface reactions. In contrast to previous work, anhydrous and anoxic techniques were used to prevent air and moisture contamination of prepared SEI films. This allowed for accurate characterization of the SEI structure and composition by X-ray photoelectron spectroscopy and time-of-flight secondary ion mass spectrometry depth profiling. These results show that FEC reduction leads to fluoride ion and LiF formation, consistent with previous computational and experimental results. Surprisingly, we also find that these species decrease lithium-ion solubility and increase the reactivity of the silicon surface. We conclude that the effectiveness of FEC at improving the Coulombic efficiency and capacity retention is due to fluoride ion formation from reduction of the electrolyte, which leads to the chemical attack of any silicon-oxide surface passivation layers and the formation of a kinetically stable SEI comprising predominately lithium fluoride and lithium oxide. (Figure Presented)
- Published
- 2015
22. Questions and controversies in innate immune research: what is the physiological role of NLRP3?
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Coll, RC, primary, O’Neill, LAJ, additional, and Schroder, K, additional
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- 2016
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23. Strain- and host species-specific inflammasome activation, IL-1β release, and cell death in macrophages infected with uropathogenic Escherichia coli
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Schaale, K, primary, Peters, K M, additional, Murthy, A M, additional, Fritzsche, A K, additional, Phan, M-D, additional, Totsika, M, additional, Robertson, A A B, additional, Nichols, K B, additional, Cooper, M A, additional, Stacey, K J, additional, Ulett, G C, additional, Schroder, K, additional, Schembri, M A, additional, and Sweet, M J, additional
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- 2016
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24. FRI-091 - RNA-sequencing analysis of biopsies from chronic liver disease patients identifies gene signatures associated with progressive liver disease
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Ramnath, D., Irvine, K., Lukowski, S., Horsfall, L., Loh, K., Clouston, A., Patel, P., Iyer, A., Lampe, G., Stow, J., Schroder, K., Fairlie, D., Powell, J., Powell, E., and Sweet, M.
- Published
- 2018
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25. The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line
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FANTOM Consortium, Suzuki H, Forrest AR, van Nimwegen E, Daub CO, Balwierz PJ, Irvine KM, Lassmann T, Ravasi T, Hasegawa Y, de Hoon MJ, Katayama S, Schroder K, Carninci P, Tomaru Y, Kanamori-Katayama M, Kubosaki A, Akalin A, Ando Y, Arner E, Asada M, Asahara H, Bailey T, Bajic VB, Bauer D, Beckhouse AG, Bertin N, Bjxf6rkegren J, Brombacher F, Bulger E, Chalk AM, Chiba J, Cloonan N, Dawe A, Dostie J, Engstrxf6m PG, Essack M, Faulkner GJ, Fink JL, Fredman D, Fujimori K, Furuno M, Gojobori T, Gough J, and Grimmond SM
- Published
- 2009
26. Osteal tissue macrophages are intercalated throughout human and mouse bone lining tissues and regulate osteoblast function in vitro and in vivo
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Chang, M. K., Raggatt, L. J., Alexander, K. A., Kuliwaba, J. S., Fazzalari, N. L., Schroder, K., Maylin, E. R., Ripoll, V. M., Hume, D. A., and Pettit, A. R.
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musculoskeletal diseases ,Calcium/metabolism ,Macrophages/physiology ,Osteocalcin/metabolism ,Osteoblasts/cytology ,Gene Expression ,Macrophages/cytology ,Bone and Bones/physiology ,Cell Differentiation ,Mice, Transgenic ,Macrophages/immunology ,Mice, Inbred C57BL ,Calcification, Physiologic ,Osteoblasts/physiology ,Osteogenesis ,Animals ,Humans ,Lipopolysaccharides/immunology ,Osteocalcin/genetics ,Bone and Bones/cytology ,Cells, Cultured - Abstract
Resident macrophages are an integral component of many tissues and are important in homeostasis and repair. This study examines the contribution of resident tissue macrophages to bone physiology. Using immunohistochemistry, we showed that a discrete population of resident macrophages, OsteoMacs, was intercalated throughout murine and human osteal tissues. OsteoMacs were distributed among other bone lining cells within both endosteum and periosteum. Furthermore, OsteoMacs were coisolated with osteoblasts in murine bone explant and calvarial preparations. OsteoMacs made up 15.9% of calvarial preparations and persisted throughout standard osteoblast differentiation cultures. Contrary to previous studies, we showed that it was OsteoMacs and not osteoblasts within these preparations that responded to pathophysiological concentrations of LPS by secreting TNF. Removal of OsteoMacs from calvarial cultures significantly decreased osteocalcin mRNA induction and osteoblast mineralization in vitro. In a Transwell coculture system of enriched osteoblasts and macrophages, we demonstrated that macrophages were required for efficient osteoblast mineralization in response to the physiological remodeling stimulus, elevated extracellular calcium. Notably, OsteoMacs were closely associated with areas of bone modeling in situ, forming a distinctive canopy structure covering >75% of mature osteoblasts on diaphyseal endosteal surfaces in young growing mice. Depletion of OsteoMacs in vivo using the macrophage-Fas-induced apoptosis (MAFIA) mouse caused complete loss of osteoblast bone-forming surface at this modeling site. Overall, we have demonstrated that OsteoMacs are an integral component of bone tissues and play a novel role in bone homeostasis through regulating osteoblast function. These observations implicate OsteoMacs, in addition to osteoclasts and osteoblasts, as principal participants in bone dynamics.
- Published
- 2008
27. The macrophage-inducible C-type lectin, mincle, is an essential component of the innate immune response to Candida albicans
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Wells, C. A., Salvage-Jones, J. A., Li, X., Hitchens, K., Butcher, S., Rachael Murray, Beckhouse, A. G., Lo, Y. L. S., Manzanero, S., Cobbold, C., Schroder, K., Ma, B., Orr, S., Stewart, L., Lebus, D., Sobieszczuk, P., Hume, D. A., Stow, J., Blanchard, H., and Ashman, R. B.
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Phagosomes/metabolism ,Toll-Like Receptor 2/immunology ,060110 Receptors and Membrane Biology ,Candida albicans/immunology ,Lectins, C-Type/genetics ,Macrophages/immunology ,INCREASES SUSCEPTIBILITY ,Cell Line ,Mice ,Phagocytosis ,Phagosomes/immunology ,Macrophages/metabolism ,INFECTION ,REVEALS ,Animals ,Humans ,Candida albicans/metabolism ,Lectins, C-Type/immunology ,Toll-Like Receptor 2/metabolism ,GENE-EXPRESSION ,TOLL-LIKE RECEPTORS ,GALECTIN-3 ,Mice, Knockout ,Tumor Necrosis Factor-alpha/metabolism ,DECTIN-1 ,Mice, Inbred BALB C ,IDENTIFICATION ,RECOGNITION ,110799 Immunology not elsewhere classified ,Macrophages/cytology ,Tumor Necrosis Factor-alpha/immunology ,Immunity, Innate ,Mice, Inbred C57BL ,MURINE MACROPHAGES ,Candidiasis/immunology ,Disease Susceptibility ,Lectins, C-Type/metabolism - Abstract
The recognition of carbohydrate moieties by cells of the innate immune system is emerging as an essential element in antifungal immunity, but despite the number and diversity of lectins expressed by innate immune cells, few carbohydrate receptors have been characterized. Mincle, a C-type lectin, is expressed predominantly on macrophages, and is here shown to play a role in macrophage responses to the yeast Candida albicans. After exposure to the yeast in vitro, Mincle localized to the phagocytic cup, but it was not essential for phagocytosis. In the absence of Mincle, production of TNF-alpha by macrophages was reduced, both in vivo and in vitro. In addition, mice lacking Mincle showed a significantly increased susceptibility to systemic candidiasis. Thus, Mincle plays a novel and nouredundant role in the induction of inflammatory signaling in response to C. albicans infection.
- Published
- 2008
28. Straits and Channels as key regions of an integrated marine observatory of the Mediterranean: our experience on their long-term monitoring
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Gasparini G.P., Schroder K., and Sparnocchia S.
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integrated marine observations ,Mediterranean Sea ,straits ,channels - Abstract
The monitoring of Mediterranean straits and channels demonstrated its ability to detect the propagation of important anomalies at basin scale, for what concerns the transport of mass heat and salt. The new available technologies are able to significantly improve the present monitoring both in term of space/time resolution and extending the coverage to biogeochemical parameters. The important task of data transmission needs to be evaluated to permit a real time monitoring and the consequent possibility to make the acquired data available for forecasting purposes.
- Published
- 2008
29. Absolute Thermoelectric Power and Electrical Resistivity of Chromium-Rich Chromium-Nickel Alloys
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Schroder, K., primary and Baum, N. P., additional
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- 1968
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30. Is There a Nordic News Media System?: A descriptive comparative analysis of Nordic news audiences
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Schrøder Kim Christian, Blach-Ørsten Mark, and Kæmsgaard Eberholst Mads
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news audiences ,media systems ,nordic countries ,comparative analysis ,online survey ,Communication. Mass media ,P87-96 - Abstract
In media systems theory, the Nordic countries are often held to constitute a specific media system (Brüggemann et al., 2014). In this article, we put this claim to the test in the area of news consumption. Based on findings about the four Nordic countries Denmark, Norway, Sweden, and Finland in the annual Reuters Institute Digital News Report (Newman et al., 2019), and inspired by previous studies of the audience dimension of media systems (Hölig et al., 2016; Peruško et al., 2015; Van Damme et al., 2017), we undertake a descriptive empirical analysis of the 2019 data of this 38-country study. Our study compares news audience practices in the Nordic countries with those of countries belonging to other supranational media systems. We find that while there are some internal differences within the Nordic media system, there are salient news consumption commonalities that are specific to the Nordic countries, such as preferred sources of news, pathways to news, paying for online news, and trust in the news.
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- 2020
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31. The local galactic mass injection from cool winds and superwinds of the 1 to 2.5 M-circle dot mass stars
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Schroder, K
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Astrophysics::Solar and Stellar Astrophysics ,Astrophysics::Earth and Planetary Astrophysics ,Astrophysics::Cosmology and Extragalactic Astrophysics ,Astrophysics::Galaxy Astrophysics - Abstract
For the local field star IMF, and based on a large number of individual stellar evolution models with a constistent description of cool wind (and superwind) mass loss, we discuss the galactic mass injection from the 1 to 2.5 M-circle dot mass stars by means of synthetic stellar samples.
- Published
- 2001
32. AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC
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Sagulenko, V, primary, Thygesen, S J, additional, Sester, D P, additional, Idris, A, additional, Cridland, J A, additional, Vajjhala, P R, additional, Roberts, T L, additional, Schroder, K, additional, Vince, J E, additional, Hill, J M, additional, Silke, J, additional, and Stacey, K J, additional
- Published
- 2013
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33. Xanthine oxidase inhibitor tungsten prevents the development of atherosclerosis in ApoE knockout mice fed a Western-type diet.
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Schroder, K. and Schroder, K.
- Abstract
Hyperlipidemia enhances xanthine oxidase (XO) activity. XO is an important source of reactive oxygen species (ROS). Since ROS are thought to promote atherosclerosis, we hypothesized that XO is involved in the development of atherosclerosis. ApoE(-/-) mice were fed a Western-type (WD) or control diet. In subgroups, tungsten (700 mg/L) was administered to inhibit XO. XO is a secreted enzyme which is formed in the liver as xanthine dehydrogenase (XDH) and binds to the vascular endothelium. High expression of XDH was found in the liver and WD increased liver XDH mRNA and XDH protein expression. WD induced the conversion of XDH to the radical-forming XO. Moreover, WD increased the hepatic expression of CD40, demonstrating activation of hepatic cells. Aortic tissue of ApoE(-/-) mice fed a WD for 6 months exhibited marked atherosclerosis, attenuated endothelium-dependent relaxation to acetylcholine, increased vascular oxidative stress, and mRNA expression of the chemokine KC. Tungsten treatment had no effect on plasma lipids but lowered the plasma XO activity. In animals fed a control diet, tungsten had no effect on radical formation, endothelial function, or atherosclerosis development. In mice fed a WD, however tungsten attenuated the vascular superoxide anion formation, prevented endothelial dysfunction, and attenuated KC mRNA expression. Most importantly, tungsten treatment largely prevented the development of atherosclerosis in the aorta of ApoE(-/-) mice on WD. Therefore, tungsten, potentially via the inhibition of XO, prevents the development of endothelial dysfunction and atherosclerosis in ApoE(-/-) mice on WD
- Published
- 2006
34. NADPH Oxidase-4 Maintains Neuropathic Pain after Peripheral Nerve Injury
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Kallenborn-Gerhardt, W., primary, Schroder, K., additional, Del Turco, D., additional, Lu, R., additional, Kynast, K., additional, Kosowski, J., additional, Niederberger, E., additional, Shah, A. M., additional, Brandes, R. P., additional, Geisslinger, G., additional, and Schmidtko, A., additional
- Published
- 2012
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35. Poster session 3
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Nanka, O., primary, Krejci, E., additional, Pesevski, Z., additional, Sedmera, D., additional, Smart, N., additional, Rossdeutsch, A., additional, Dube, K. N., additional, Riegler, J., additional, Price, A. N., additional, Taylor, A., additional, Muthurangu, V., additional, Turner, M., additional, Lythgoe, M. F., additional, Riley, P. R., additional, Kryvorot, S., additional, Vladimirskaya, T., additional, Shved, I., additional, Schwarzl, M., additional, Seiler, S., additional, Huber, S., additional, Steendijk, P., additional, Maechler, H., additional, Truschnig-Wilders, M., additional, Pieske, B., additional, Post, H., additional, Caprio, C., additional, Baldini, A., additional, Chiavacci, E., additional, Dolfi, L., additional, Verduci, L., additional, Meghini, F., additional, Cremisi, F., additional, Pitto, L., additional, Kuan, T.-C., additional, Chen, M.-C., additional, Yang, T.-H., additional, Wu, W.-T., additional, Lin, C. S., additional, Rai, H., additional, Kumar, S., additional, Sharma, A. K., additional, Mastana, S., additional, Kapoor, A., additional, Pandey, C. M., additional, Agrawal, S., additional, Sinha, N., additional, Orlowska-Baranowska, E. H., additional, Placha, G., additional, Gora, J., additional, Baranowski, R., additional, Abramczuk, E., additional, Hryniewiecki, T., additional, Gaciong, Z., additional, Verschuren, J. J. W., additional, Wessels, J. A. M., additional, Trompet, S., additional, Stott, D. J., additional, Sattar, N., additional, Buckley, B., additional, Guchelaar, H. J., additional, Jukema, J. W., additional, Gharanei, M., additional, Hussain, A., additional, Mee, C. J., additional, Maddock, H. L., additional, Wijnen, W. J., additional, Van Den Oever, S., additional, Van Der Made, I., additional, Hiller, M., additional, Tijsen, A. J., additional, Pinto, Y. M., additional, Creemers, E. E., additional, Nikulina, S. U. 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J., additional, Llacer, A., additional, Galasso, G., additional, Ferrara, N., additional, Akhmedov, A., additional, Klingenberg, R., additional, Brokopp, C., additional, Hof, D., additional, Zoller, S., additional, Corti, R., additional, Gay, S., additional, Von Eckardstein, A., additional, Hoerstrup, S. P., additional, Luescher, T. F., additional, Heijman, J., additional, Zaza, A., additional, Johnson, D. M., additional, Rudy, Y., additional, Peeters, R. L. M., additional, Volders, P. G. A., additional, Westra, R. L., additional, Fujita, S., additional, Okamoto, R., additional, Taniguchi, M., additional, Konishi, K., additional, Goto, I., additional, Sugimoto, K., additional, Nakamura, M., additional, Shiraki, K., additional, Buechler, C., additional, and Ito, M., additional
- Published
- 2012
- Full Text
- View/download PDF
36. Scaling up oral rehydration salts and zinc for the treatment of diarrhoea
- Author
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Sabot, O., primary, Schroder, K., additional, Yamey, G., additional, and Montagu, D., additional
- Published
- 2012
- Full Text
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37. The death domain-containing protein Unc5CL is a novel MyD88-independent activator of the pro-inflammatory IRAK signaling cascade
- Author
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Heinz, L X, primary, Rebsamen, M, additional, Rossi, D C, additional, Staehli, F, additional, Schroder, K, additional, Quadroni, M, additional, Gross, O, additional, Schneider, P, additional, and Tschopp, J, additional
- Published
- 2011
- Full Text
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38. Flexible solar cells in milliseconds: Pulse Thermal Processing of CdTe devices
- Author
-
Murray, S. L., primary, Klein, A. R., additional, Murray, C. S., additional, Schroder, K. A., additional, Rawson, I. M., additional, Ju, T., additional, Evans, B. M., additional, Angelini, J. A., additional, Harper, D. C., additional, Tillett, D., additional, Duty, C. E., additional, Ott, R. D., additional, Blue, C. A., additional, Rivard, J. D., additional, Gessert, T., additional, and Noufi, R., additional
- Published
- 2011
- Full Text
- View/download PDF
39. A Volumetric Approach to Predictive Rendering of Fabrics
- Author
-
Schroder, K., primary, Klein, R., additional, and Zinke, A., additional
- Published
- 2011
- Full Text
- View/download PDF
40. Subacromial corticosteroid injection or acupuncture with home exercises when treating patients with subacromial impingement in primary care--a randomized clinical trial
- Author
-
Johansson, K., primary, Bergstrom, A., additional, Schroder, K., additional, and Foldevi, M., additional
- Published
- 2011
- Full Text
- View/download PDF
41. Photonic Curing Explanation and Application to Printing Copper Traces on Low Temperature Substrates
- Author
-
Schroder, K. A., primary, Rawson, Ian M., additional, Pope, Dave S., additional, and Farnsworth, S., additional
- Published
- 2011
- Full Text
- View/download PDF
42. Advances in robot calibration: Modelling, Parameter Identification, Measurement
- Author
-
Schroder, K., Albright, S.L., Grethlein, M., Lisounkin, A., van Albada, G.D., Lagerberg, J.M., Visser, A., and Computational Science Lab (IVI, FNWI)
- Published
- 1994
43. Calibration applied to quality control in robot production
- Author
-
Schroder, K., Bernhardt, R., Albright, S.L., Worn, H., Kyle, S., van Albada, G.D., Smyth, J., Meyer, R., Zaremba, M., and Computational Science Lab (IVI, FNWI)
- Published
- 1994
44. Update of the FANTOM web resource: from mammalian transcriptional landscape to its dynamic regulation
- Author
-
Kawaji, H., primary, Severin, J., additional, Lizio, M., additional, Forrest, A. R. R., additional, van Nimwegen, E., additional, Rehli, M., additional, Schroder, K., additional, Irvine, K., additional, Suzuki, H., additional, Carninci, P., additional, Hayashizaki, Y., additional, and Daub, C. O., additional
- Published
- 2010
- Full Text
- View/download PDF
45. Evaluation of PulseForge Tool for Processing Metallic Conductive Inks on Low Temperature Substrates Part II: Screen Inks
- Author
-
Farnsworth, S., primary, Rawson, I., additional, Schroder, K. A., additional, and Pope, D., additional
- Published
- 2010
- Full Text
- View/download PDF
46. Radiation emissions during laser processing
- Author
-
Hietanen, M., Schroder, K., and Meijer, J.
- Subjects
METIS-145334 - Published
- 1993
47. Magnetization changes by superimposed stress pulses
- Author
-
Onengut, D and Schroder, K
- Subjects
Solid-State Physics - Abstract
The magnetization of a BiMn alloy with ferromagnetic inclusions changes at constant magnetic field, if the sample is subjected to ultrasonic pulses. The magnetization changes can be described on the basis of the Stoner-Wohlfarth theory of coherent rotation. It is possible to change the magnetization in selected volume elements by superimposing short pulses in those volume elements.
- Published
- 1979
48. A new sampling transfer standard of highest accuracy for AC quantities
- Author
-
Kurten Ihlenfeld, W. G., primary, Iuzzolino, R., additional, Otto, R., additional, Schroder, K., additional, Putensen, U., additional, and Huettemann, H., additional
- Published
- 2008
- Full Text
- View/download PDF
49. Creep at elevated temperatures and high vacuum Final report, 1 Jan. - 30 Nov. 1968
- Author
-
Giannuzzi, A, Gorsha, G, and Schroder, K
- Subjects
Materials, Metallic - Abstract
Effects of elevated temperature and high vacuum on creep rate of copper and silver wires
- Published
- 1968
50. Creep at elevated temperatures and high vacuum Semiannual report no. 4
- Author
-
Giannuzzi, A, Gorsha, G, and Schroder, K
- Subjects
Materials, Metallic - Abstract
Creep tests on high purity copper wires in high vacuum in argon bombarded clean state and after oxidization in air
- Published
- 1966
Catalog
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