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3. Cord blood allergen-specific IgE is associated with reduced IFN-γ production by cord blood cells: The Protection against Allergy—Study in Rural Environments (PASTURE) study

Author

Pfefferle, Petra Ina, Sel, Serdar, Ege, Markus Johannes, Büchele, Gisela, Blümer, Nicole, Krauss-Etschmann, Susanne, Herzum, Ileana, Albers, Christoph E., Lauener, Roger P., Roponen, Marjut, Hirvonen, Maija-Riitta, Vuitton, Dominique A., Riedler, Josef, Brunekreef, Bert, Dalphin, Jean-Charles, Braun-Fahrländer, Charlotte, Pekkanen, Juha, von Mutius, Erika, and Renz, Harald

Published
2008

6. Cord blood allergen-specific IgE is associated with reduced IFN-gamma production by cord blood cells: the Protection against Allergy-Study in Rural Environments (PASTURE) Study

Author

Pfefferle , Petra Ina, Sel , Serdar, Ege , Markus Johannes, Büchele , Gisela, Blümer , Nicole, Krauss-Etschmann , Susanne, Herzum , Ileana, Albers , Christoph E, Lauener , Roger P, Roponen , Marjut, Hirvonen , Maija-Riitta, Vuitton , Dominique A, Riedler , Josef, Brunekreef , Bert, Dalphin , Jean-Charles, Braun-Fahrländer , Charlotte, Pekkanen , Juha, Von Mutius , Erika, Renz , Harald, Renseigné , Non, WHO Collaborating Center on Prevention and Treatment of Human Echinococcosis, SERF Unit, Université de Franche-Comté ( UFC ), Division of Occupational and Environmental Health, Institute for Risk Assessment ( IRAS ), Utrecht University [Utrecht], Laboratoire Chrono-environnement ( LCE ), Université Bourgogne Franche-Comté ( UBFC ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Franche-Comté ( UFC ), European Project : 211911,EC:FP7:KBBE,FP7-KBBE-2007-1,EFRAIM ( 2008 ), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Division of Occupational and Environmental Health, Institute for Risk Assessment (IRAS), Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), European Project: 211911,EC:FP7:KBBE,FP7-KBBE-2007-1,EFRAIM(2008), Laboratoire Chrono-environnement - CNRS - UFC (UMR 6249) (LCE), and Laboratoire Chrono-environnement (UMR 6249) (LCE)

Subjects
Male, Rural Population, Allergy, MESH : Prospective Studies, medicine.disease_cause, Immunoglobulin E, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, Allergic sensitization, MESH: Pregnancy, 0302 clinical medicine, Allergen, MESH: Rural Population, Antibody Specificity, Pregnancy, Immunology and Allergy, MESH : Female, Prospective Studies, Sensitization, MESH : Allergens, MESH : Antibody Specificity, 0303 health sciences, biology, MESH: Immunoglobulin E, MESH: Infant, Newborn, MESH : Adult, Fetal Blood, 3. Good health, Europe, medicine.anatomical_structure, Cord blood, Female, Antibody, Food Hypersensitivity, Adult, MESH : Food Hypersensitivity, MESH: Allergens, MESH : Interleukin-5, MESH: Interferon-gamma, MESH : Male, Immunology, MESH : Europe, MESH : Infant, Newborn, MESH : Immunoglobulin E, 03 medical and health sciences, Interferon-gamma, Immune system, medicine, Humans, MESH: Fetal Blood, MESH: Antibody Specificity, MESH : Interferon-gamma, 030304 developmental biology, MESH : Fetal Blood, MESH: Humans, business.industry, MESH : Humans, Infant, Newborn, MESH: Adult, Allergens, MESH: Interleukin-5, medicine.disease, MESH: Male, MESH: Prospective Studies, MESH : Rural Population, MESH : Pregnancy, 030228 respiratory system, MESH: Food Hypersensitivity, biology.protein, MESH: Europe, Interleukin-5, business, MESH: Female, [ SDV.MHEP.PSR ] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract
Abstract

International audience; BACKGROUND: It is currently discussed whether allergic sensitization may start in utero under the influence of the maternal immune system and environmental determinants. OBJECTIVE: To investigate the relationship between allergen-specific cord blood (CB) IgE levels, parental sensitization, CB cytokine production, and environmental influences. METHODS: As part of an ongoing multicenter birth cohort study, allergen-specific IgE antibodies against 20 common seasonal, perennial, and food allergens were measured in blood samples from 922 neonates, 922 mothers, and 835 fathers. Supernatants from stimulated CB cells were assessed for the production of IL-5, IFN-gamma, IL-10, and TNF-alpha. RESULTS: Allergen-specific IgE antibodies were detectable in 23.9% of newborns. Contamination with maternal serum was excluded by several means of analyses, including the absence of IgA antibodies. Clear correlation between maternal and fetal IgE was found only for hen's egg, cow's milk, and soybean allergen. Fetal IgE correlated negatively with the level of IFN-gamma production, but not with IL-5 and IL-10. CONCLUSION: Allergen-specific IgE antibodies most probably of fetal origin are detectable in CB and correlate with a lowered CB IFN-gamma production.

Published
2008

8. Anti‐ulcer treatment during pregnancy induces food allergy in mouse mothers and a Th2‐bias in their offspring

Author

Schöll, Isabella, primary, Ackermann, Ute, additional, Özdemir, Cevdet, additional, Blümer, Nicole, additional, Dicke, Tanja, additional, Sel, Serdar, additional, Sel, Sarper, additional, Wegmann, Michael, additional, Szalai, Krisztina, additional, Knittelfelder, Regina, additional, Untersmayr, Eva, additional, Scheiner, Otto, additional, Garn, Holger, additional, Jensen-Jarolim, Erika, additional, and Renz, Harald, additional

Published
2007
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11. Cord blood allergen-specific IgE is associated with reduced IFN-gamma production by cord blood cells: the Protection against Allergy-Study in Rural Environments (PASTURE) Study.

Author

Pfefferle PI, Sel S, Ege MJ, Büchele G, Blümer N, Krauss-Etschmann S, Herzum I, Albers CE, Lauener RP, Roponen M, Hirvonen MR, Vuitton DA, Riedler J, Brunekreef B, Dalphin JC, Braun-Fahrländer C, Pekkanen J, von Mutius E, and Renz H

Subjects
Adult, Antibody Specificity immunology, Europe, Female, Fetal Blood immunology, Food Hypersensitivity immunology, Humans, Immunoglobulin E immunology, Infant, Newborn, Interferon-gamma immunology, Interleukin-5 blood, Interleukin-5 immunology, Male, Pregnancy, Prospective Studies, Rural Population, Allergens immunology, Fetal Blood metabolism, Food Hypersensitivity blood, Immunoglobulin E blood, Interferon-gamma biosynthesis
Abstract

Background: It is currently discussed whether allergic sensitization may start in utero under the influence of the maternal immune system and environmental determinants., Objective: To investigate the relationship between allergen-specific cord blood (CB) IgE levels, parental sensitization, CB cytokine production, and environmental influences., Methods: As part of an ongoing multicenter birth cohort study, allergen-specific IgE antibodies against 20 common seasonal, perennial, and food allergens were measured in blood samples from 922 neonates, 922 mothers, and 835 fathers. Supernatants from stimulated CB cells were assessed for the production of IL-5, IFN-gamma, IL-10, and TNF-alpha., Results: Allergen-specific IgE antibodies were detectable in 23.9% of newborns. Contamination with maternal serum was excluded by several means of analyses, including the absence of IgA antibodies. Clear correlation between maternal and fetal IgE was found only for hen's egg, cow's milk, and soybean allergen. Fetal IgE correlated negatively with the level of IFN-gamma production, but not with IL-5 and IL-10., Conclusion: Allergen-specific IgE antibodies most probably of fetal origin are detectable in CB and correlate with a lowered CB IFN-gamma production.

Published
2008
Full Text
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12. Analysis of cytokine levels in human lymphangiomas.

Author

Wiegand S, Eivazi B, Sel S, Renz H, Werner JA, and Folz BJ

Subjects
Biological Assay, Child, Female, Follow-Up Studies, Humans, Infant, Male, Time Factors, Cytokines analysis, Lymphangioma, Cystic immunology, Lymphangioma, Cystic metabolism
Abstract

Background: Different theories concerning the origin of lymphangiomas have been formulated but their precise pathogenesis is still unknown. This study aimed to analyze the levels of different cytokines in lymphangioma cyst fluids., Materials and Methods: Fluid aspirates from lymphangioma cysts of five patients were obtained. The intracystic levels of interleukin (IL)-6, IL-8, IL-2R and tumor necrosis factor alpha (TNFalpha) were determined in four cases before and one case after OK-432 administration using an immunometric assay., Results: Increased IL-6 levels were observed in all cases. Moreover, elevated IL-2R and TNFalpha levels were observed in three out of four and elevated IL-8 levels in two out of four untreated cases. There was a 25-fold increase in IL-6 after repeated OK-432 injections while IL-8, IL-2R and TNFalpha levels did not change significantly., Conclusion: These findings suggest that cytokines may be involved in the pathogenesis of lymphangiomas.

Published
2008

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