33,687 results on '"Severino A"'
Search Results
2. Syringomyelia: Retrospective Analysis of 30 Surgically Treated Patients from the Northeast of Brazil
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Bruna Lisboa do Vale, Maurus Marques de Almeida Holanda, Marcelo Moraes Valença, and Severino Aires de Araújo Neto
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craniocervical junction malformations ,syringomyelia ,Chiari malformation ,basilar impression ,surgery ,malformações da junção craniocervical ,siringomielia ,malformação de Chiari ,impressão basilar ,cirurgia ,Medicine ,Surgery ,RD1-811 - Abstract
Introduction Syringomyelia is a chronic disease characterized by the presence of intramedullary cavity. Chiari malformation (CM) and basilar impression (BI) are conditions usually associated with syringomyelia. Its prevalence has wide geographical variation, being higher in the Northeast of Brazil, making it relevant to study the subject in this region.
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- 2024
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3. Effect of laser photobiomodulation combined with hydroxyapatite nanoparticles on the osteogenic differentiation of mesenchymal stem cells using artificial intelligence: An in vitro study.
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Eloiza Leonardo de Melo, Jéssica Meirinhos Miranda, Vanessa Bastos de Souza Rolim Lima, Wyndly Daniel Cardoso Gaião, Braulio de Vilhena Amorim Tostes, Claudio Gabriel Rodrigues, Márcia Bezerra da Silva, Severino Alves Júnior, Edson Luiz Pontes Perger, Mávio Eduardo Azevedo Bispo, and Marleny Elizabeth Márquez de Martínez Gerbi
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Medicine ,Science - Abstract
AimTo evaluate in vitro the effect of laser photobiomodulation (PBM) combined or not with 30-nm hydroxyapatite nanoparticles (HANp), on the osteogenic differentiation of human umbilical cord mesenchymal stem cells (hUC-MSCs) by morphometric analysis using artificial intelligence programs (TensorFlow and ArcGIS).MethodsUC-MSCs were isolated and cultured until 80% confluence was reached. The cells were then plated according to the following experimental groups: G1 -control (DMEM), G2 -BMP-2, G3 -BMP-7, G4 -PBM (660 nm, 10 mW, 2.5 J/cm2, spot size of 0.08 cm2), G5 -HANp, G6 -HANp + PBM, G7 -BMP-2 + PBM, and G8 -BMP-7 + PBM. The MTT assay was used to analyze cell viability at 24, 48 and 72 h. Osteogenic differentiation was assessed by Alizarin Red staining after 7, 14 and 21 days. For morphometric analysis, areas of osteogenic differentiation (pixel2) were delimited by machine learning using the TensorFlow and ArcGIS 10.8 programs.ResultsThe results of the MTT assay showed high rates of cell viability and proliferation in all groups when compared to control. Morphometric analysis revealed a greater area of osteogenic differentiation in G5 (HANp = 142709,33±36573,39) and G6 (HANp + PBM = 125452,00±24226,95) at all time points evaluated.ConclusionIt is suggested that HANp, whether combined with PBM or not, may be a promising alternative to enhance the cellular viability and osteogenic differentiation of hUC-MSCs.
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- 2024
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4. Gamma radiation effect on the chemical, mechanical and thermal properties of PCL/MCM-48-PVA nanocomposite films
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Marcos Vinícius da Silva Paula, Leandro Araújo de Azevedo, Ivo Diego de Lima Silva, Carlos Alberto Brito da Silva, Jr., Glória Maria Vinhas, and Severino Alves, Jr.
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Polycaprolactone (PCL) ,poly(vinyl alcohol) (PVA) ,Nanocomposite (NC) films ,Gamma radiation ,MCM-48-M ,Chemical properties ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
In this work, poly (vinyl alcohol) (PVA) was employed to produce a Mesoporous Composition of Matter-48 Modified (MCM-48-M or MCM-48-PVA). After surface modification, MCM-48-M was used to produce nanocomposite (NC) films with polycaprolactone (PCL) as a matrix at room temperature. PCL and MCM-48 nanoparticles (NPs) were chosen due to their great biocompatibility and low toxicity. However, MCM-48-M is more compatible with PCL than MCM-48. NC films were sterilized by gamma radiation with a dose of 25 kGy and characterized by experimental techniques to investigate their chemical, mechanical (tensile) and thermal properties. Scanning electron microscopy (SEM) and transmission electronic microscopy (TEM) results indicated that MCM-48-M exhibited a random distribution in the PCL matrix. The PCL chemical structure was preserved in NC films as described by Fourier transform infrared (FT-IR) spectroscopy as well as the tensile and thermal properties of NC films. FT-IR and thermogravimetric analysis (TGA) results showed surface modification. X-ray diffraction (XRD) and differential scanning calorimetry (DSC) showed that crystalline symmetries were preserved and the crystallinity of NC films had small variations in all samples before and after irradiation, respectively. But, our results did not indicate major changes showing that this method is successful for the sterilization of PCL/MCM-48-PVA NC films.
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- 2023
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5. Non-perturbative intertwining between spin and charge correlations: A ``smoking gun' single-boson-exchange result
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Severino Adler, Friedrich Krien, Patrick Chalupa-Gantner, Giorgio Sangiovanni, Alessandro Toschi
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Physics ,QC1-999 - Abstract
We study the microscopic mechanism controlling the interplay between local charge and local spin fluctuations in correlated electron systems via a thorough investigation of the generalized on-site charge susceptibility of several fundamental many-electron models, such as the Hubbard atom, the Anderson impurity model, and the Hubbard model. By decomposing the numerically determined generalized susceptibility in terms of physically transparent single-boson exchange processes, we unveil the microscopic mechanisms responsible for the breakdown of the self-consistent many-electron perturbation expansion. In particular, we unambiguously identify the origin of the significant suppression of its diagonal entries in (Matsubara) frequency space and the slight increase of the off-diagonal ones which cause the breakdown. The suppression effect on the diagonal elements originates directly from the electronic scattering on local magnetic moments, reflecting their increasingly longer lifetime as well as their enhanced effective coupling with the electrons. Instead, the slight and diffuse enhancement of the off-diagonal terms can be mostly ascribed to multiboson scattering processes. The strong intertwining between spin and charge sectors is partly weakened at the Kondo temperature due to a progressive reduction of the effective spin-fermion coupling of local magnetic fluctuations in the low frequency regime. Our analysis, thus, clarifies the precise mechanism through which the physical information is transferred between different scattering channels of interacting electron problems and highlights the pivotal role played by such an intertwining in the physics of correlated electrons beyond the perturbative regime.
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- 2024
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6. Dislocations and Fibrations: The Topological Structure of Knotted Smectic Defects
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Severino, Paul G., Kamien, Randall D., and Bode, Benjamin
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Condensed Matter - Soft Condensed Matter ,Mathematical Physics ,Mathematics - Algebraic Topology ,Mathematics - Geometric Topology - Abstract
In this work, we investigate the topological properties of knotted defects in smectic liquid crystals. Our story begins with screw dislocations, whose radial surface structure can be smoothly accommodated on $S^3$ for fibred knots by using the corresponding knot fibration. To understand how a smectic texture may take on a screw dislocation in the shape of a knot without a fibration, we study first knotted edge defects. Unlike screw defects, knotted edge dislocations force singular points in the system for any non-trivial knot. We provide a lower bound on the number of such point defects required for a given edge dislocation knot and draw an analogy between the point defect structure of knotted edge dislocations and that of focal conic domains. By showing that edge dislocations, too, are sensitive to knot fibredness, we reinterpret the so-called Morse-Novikov points required for non-fibred screw dislocation knots as analogous smectic defects. Our methods are then applied to $+1/2$ and negative-charge disclinations in the smectic phase, furthering the analogy between knotted smectic defects and focal conic domains and uncovering an intricate relationship between point and line defects in smectic liquid crystals. The connection between smectic defects and knot theory not only unravels the uniquely topological knotting of smectic defects but also provides a mathematical and experimental playground for modern questions in knot and Morse-Novikov theory.
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- 2024
7. Upper semicontinuity for a class of nonlocal evolution equations with Neumann condition
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Bezerra, Flank D. M., Sastre-Gomez, Silvia, and da Silva, Severino H.
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Mathematics - Analysis of PDEs - Abstract
In this paper we consider the following nonlocal autonomous evolution equation in a bounded domain $\Omega$ in $\mathbb{R}^N$ \[ \partial_t u(x,t) =- h(x)u(x,t) + g \Big(\int_{\Omega} J(x,y)u(y,t)dy \Big) +f(x,u(x,t)) \] where $h\in W^{1,\infty}(\Omega)$, $g: \mathbb{R} \to \mathbb{R}$ and $f:\mathbb{R}^N\times\mathbb{R} \to \mathbb{R}$ are continuously differentiable function, and $J$ is a symmetric kernel; that is, $J(x,y)=J(y,x)$ for any $x,y\in\mathbb{R}^N$. Under additional suitable assumptions on $f$ and $g$, we study the asymptotic dynamics of the initial value problem associated to this equation in a suitable phase spaces. More precisely, we prove the existence, and upper semicontinuity of compact global attractors with respect to kernel $J$.
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- 2024
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8. Silicon Spin Qubit Control and Readout Circuits in 22nm FDSOI CMOS
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Severino, Raffaele R., Spasaro, Michele, and Zito, Domenico
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Quantum Physics - Abstract
This paper investigates the implementation of microwave and mm-wave integrated circuits for control and readout of electron/hole spin qubits, as elementary building blocks for future emerging quantum computing technologies. In particular, it summarizes the most relevant readout and control techniques of electron/hole spin qubits, addresses the feasibility and reports some preliminary simulation results of two blocks: transimpedance amplifier (TIA) and pulse generator (PG). The TIA exhibits a transimpedance gain of 108.5 dB Ohm over a -3dB bandwidth of 18 GHz, with input-referred noise current spectral density of 0.89 pA/root(Hz) at 10 GHz. The PG provides a mm-wave sinusoidal pulse with a minimum duration time of 20 ps., Comment: The final version of this draft has been appearing in the Proceedings of ISCAS 2020 available on IEEE Explore Digital Library
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- 2024
9. Implementation and Outcomes of Outdoor Science Education in an Urban Setting on Primary and Intermediate Level Students with Emotional and Behavioral Disorders
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Cora Delores, Christopher Roemmele, and Brittany Severino
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The term nature deficit disorder describes the "human costs of alienation from nature" (Louv, 2019). While not meant to be a medical diagnosis, Louv argues that the condition has, "profound implications, not only for the health of future generations but for the health of the earth itself" (Louv, 2008). Children most at risk are those who live or go to school in an urban setting, as well as students diagnosed with Emotional and Behavioral Disorders (EBD). Students diagnosed with EBD are often kept indoors as their teachers and caretakers are frequently trained in the indoor use only of behavior management techniques (Riden et al., 2022). This means that during professional development training, any that pertain to behavior management techniques, procedure, or protocol are routinely taught inside of a classroom, conference room, or recently home office, using an indoor scenario (classroom, auditorium, cafeteria, etc.) as an example of when and how to use these behavior management tools. Outdoor professional development, equipping students with natural tools that can help improve not only their physical but also their mental health, as well as connecting students with nature in a way that teaches them to advocate for the health of the earth, thus becoming citizen stewards are all themes that are part of the massive, currently dysfunctional system that is outdoor education in schools. This study shows that when students are encouraged to interact with nature on their own terms on-task behaviors and motivation increase. Students also retained lesson information and asked follow-up questions after the lesson when taught outside using hands-on activities.
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- 2024
10. A 3D approach to understanding heterogeneity in early developing autisms.
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Mandelli, Veronica, Severino, Ines, Eyler, Lisa, Pierce, Karen, Courchesne, Eric, and Lombardo, Michael
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Clustering ,Gene expression ,Stratification ,Subtypes ,fMRI ,Humans ,Child ,Preschool ,Autistic Disorder ,Female ,Male ,Child ,Phenotype ,Imaging ,Three-Dimensional - Abstract
BACKGROUND: Phenotypic heterogeneity in early language, intellectual, motor, and adaptive functioning (LIMA) features are amongst the most striking features that distinguish different types of autistic individuals. Yet the current diagnostic criteria uses a single label of autism and implicitly emphasizes what individuals have in common as core social-communicative and restricted repetitive behavior difficulties. Subtype labels based on the non-core LIMA features may help to more meaningfully distinguish types of autisms with differing developmental paths and differential underlying biology. METHODS: Unsupervised data-driven subtypes were identified using stability-based relative clustering validation on publicly available Mullen Scales of Early Learning (MSEL) and Vineland Adaptive Behavior Scales (VABS) data (n = 615; age = 24-68 months) from the National Institute of Mental Health Data Archive (NDA). Differential developmental trajectories between subtypes were tested on longitudinal data from NDA and from an independent in-house dataset from UCSD. A subset of the UCSD dataset was also tested for subtype differences in functional and structural neuroimaging phenotypes and relationships with blood gene expression. The current subtyping model was also compared to early language outcome subtypes derived from past work. RESULTS: Two autism subtypes can be identified based on early phenotypic LIMA features. These data-driven subtypes are robust in the population and can be identified in independent data with 98% accuracy. The subtypes can be described as Type I versus Type II autisms differentiated by relatively high versus low scores on LIMA features. These two types of autisms are also distinguished by different developmental trajectories over the first decade of life. Finally, these two types of autisms reveal striking differences in functional and structural neuroimaging phenotypes and their relationships with gene expression and may highlight unique biological mechanisms. LIMITATIONS: Sample sizes for the neuroimaging and gene expression dataset are relatively small and require further independent replication. The current work is also limited to subtyping based on MSEL and VABS phenotypic measures. CONCLUSIONS: This work emphasizes the potential importance of stratifying autism by a Type I versus Type II distinction focused on LIMA features and which may be of high prognostic and biological significance.
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- 2024
11. Machine Learning for Equitable Load Shedding: Real-time Solution via Learning Binding Constraints
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Zhou, Yuqi, Severino, Joseph, Vijayshankar, Sanjana, Ugirumurera, Juliette, and Sanyal, Jibo
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Electrical Engineering and Systems Science - Systems and Control ,Computer Science - Artificial Intelligence - Abstract
Timely and effective load shedding in power systems is critical for maintaining supply-demand balance and preventing cascading blackouts. To eliminate load shedding bias against specific regions in the system, optimization-based methods are uniquely positioned to help balance between economical and equity considerations. However, the resulting optimization problem involves complex constraints, which can be time-consuming to solve and thus cannot meet the real-time requirements of load shedding. To tackle this challenge, in this paper we present an efficient machine learning algorithm to enable millisecond-level computation for the optimization-based load shedding problem. Numerical studies on both a 3-bus toy example and a realistic RTS-GMLC system have demonstrated the validity and efficiency of the proposed algorithm for delivering equitable and real-time load shedding decisions.
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- 2024
12. Port-Hamiltonian Modeling and Control of Electric Vehicle Charging Stations
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Gernandt, Hannes, Severino, Bernardo, Zhang, Xinyi, Mehrmann, Volker, and Strunz, Kai
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Mathematics - Optimization and Control - Abstract
Electric vehicles (EV) are an important part of future sustainable transportation. The increasing integration of EV charging stations (EVCSs) in the existing power grids require new scaleable control algorithms that maintain the stability and resilience of the grid. Here, we present such a control approach using an averaged port-Hamiltonian model. In this approach, the underlying switching behavior of the power converters is approximated by an averaged non-linear system. The averaged models are used to derive various types of stabilizing controllers, including the typically used PI controllers. The pH modeling is showcased by means of a generic setup of an EVCS, where the battery of the vehicle is connected to an AC grid via power lines, converters, and filters. Finally, the control design methods are compared for the averaged pH system and validated using a simulation model of the switched charging station.
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- 2024
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13. Design and First Tests of the Trapped Electrons Experiment T-REX
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Romano, Francesco, Bars, Guillaume Le, Loizu, Joaquim, Nöel, Marc, Hogge, Jean-Philippe, Alberti, Stefano, Genoud, Jeremy, Antonioni, Severino, Naux, Lorraine, Giroud-Garampon, Pierrick, Couturier, Steve, Leresche, Thierry, and Fasel, Damien
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Physics - Plasma Physics - Abstract
Gyrotrons are essential for electron cyclotron resonance heating (ECRH) in fusion reactors, making efficient operation crucial for advancing fusion energy. Past experiments revealed instability issues due to trapped electrons in the magnetron injection gun (MIG) region, causing undesired currents and operational failures. To address this, tight manufacturing tolerances are required for the MIG geometry [1]. We present initial findings of the TRapped Electrons eXperiment (T-REX) developed at the Swiss Plasma Center, designed to understand the physics of electron clouds in gyrotron MIGs. T-REX replicates MIG geometries, as well as their typical electric and magnetic fields, and it is supported by 2D Particle-in-Cell (PIC) simulations with the FENNECS code [2, 3]. The setup includes two coaxial electrodes in a vacuum chamber atop a superconducting magnet, with a central electrode biased to negative DC voltages and an outer one at ground, creating a radial electric field (1 to 2 MV/M) and an axial magnetic field (B < 0.4 T). This setup mimics Penning-Malmberg traps. We present the experimental device and first findings on current distribution and also qualitative comparison with FENNECS simulations [4]. Planned diagnostics include optical emission spectroscopy, phosphor screen imaging, Streak camera imaging, and potentially electric field distribution via the Stark effect. This research aims to enhance gyrotron performance and reliability in fusion energy systems.
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- 2024
14. Folkcomunicação e desenvolvimento local: um estudo sobre a Aruenda da Saudade e suas contribuições para o Folkturismo no município de Pitimbu-PB
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Alexandre Dutra da Silva and Severino Alves de Lucena Filho
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aruenda da saudade ,folkcomunicação ,folkturismo ,local development ,Communication. Mass media ,P87-96 - Abstract
Este trabalho analisa, sob a perspectiva da Folkcomunicação, como a Manifestação Cultural Aruenda da Saudade contribui para o Folkturismo e o Desenvolvimento Local no Município de Pitimbu no estado da Paraíba. A pesquisa é de natureza qualitativa com base em estudo de caso da manifestação cultural. Para obtenção dos dados foram utilizadas entrevistas com roteiro semiestruturado, observações e registros fotográficos. Os resultados da pesquisa evidenciaram que as estratégias de Folkturismo utilizadas pela Aruenda da Saudade, além de promover o turismo, têm contribuído para a consolidação do sentimento de pertencimento, identificação e valorização da cultura local, geração de renda para os artesãos e a consequente promoção do desenvolvimento local.
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- 2020
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15. Estado da Arte e Bibliometria da Folkcomunicação: Folkmarketing no Festival Folclórico de Parintins
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Ana Paula Almeida Miranda and Severino Alves de Lucena Filho
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folkcommunication ,folkmarketing ,marketing communication ,popular culture ,parintins ,Communication. Mass media ,P87-96 - Abstract
A presente pesquisa pretende apresentar os estudos acadêmicos que foram realizados com base na teoria da folkcomunicação com foco em folkmarketing, que é uma estratégia de comunicação organizacional, no período que compreende os anos de 2009 a 2018 (10 anos). O estado da arte proporciona embasamento e comprova a viabilidade de uma pesquisa. Comprova ainda que o estudo contribui para o campo de atuação da Folkcomunicação e do Folkmarketing, como teorias da comunicação. Possui relevância para a área acadêmica, pois, apesar de serem genuinamente brasileiras, seu uso ainda se mostra escasso e precisa ser propagado no campo das pesquisas, especialmente em comunicação, por sua relevância social (estudos que priorizam as minorias que se situam à margem da sociedade). Conclui-se que os estudos bibliométricos são ferramentas de inestimável valor para a área da ciência da informação, por aplicar métodos estatísticos e matemáticos a fim de analisar e construir indicadores sobre a dinâmica e evolução da informação científica e tecnológica quantificando os processos de comunicação escrita, para os periódicos e para o desenvolvimento da ciência como um todo.
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- 2020
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16. Radioactive polymeric nanoparticles for biomedical application
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Shentian Wu, Edward Helal-Neto, Ana Paula dos Santos Matos, Amir Jafari, Ján Kozempel, Yuri José de Albuquerque Silva, Carolina Serrano-Larrea, Severino Alves Junior, Eduardo Ricci-Junior, Frank Alexis, and Ralph Santos-Oliveira
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nanoparticles ,polymers ,nanoradiopharmaceuticals ,radionuclides ,medical imaging ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Nowadays, emerging radiolabeled nanosystems are revolutionizing medicine in terms of diagnostics, treatment, and theranostics. These radionuclides include polymeric nanoparticles (NPs), liposomal carriers, dendrimers, magnetic iron oxide NPs, silica NPs, carbon nanotubes, and inorganic metal-based nanoformulations. Between these nano-platforms, polymeric NPs have gained attention in the biomedical field due to their excellent properties, such as their surface to mass ratio, quantum properties, biodegradability, low toxicity, and ability to absorb and carry other molecules. In addition, NPs are capable of carrying high payloads of radionuclides which can be used for diagnostic, treatment, and theranostics depending on the radioactive material linked. The radiolabeling process of nanoparticles can be performed by direct or indirect labeling process. In both cases, the most appropriate must be selected in order to keep the targeting properties as preserved as possible. In addition, radionuclide therapy has the advantage of delivering a highly concentrated absorbed dose to the targeted tissue while sparing the surrounding healthy tissues. Said another way, radioactive polymeric NPs represent a promising prospect in the treatment and diagnostics of cardiovascular diseases such as cardiac ischemia, infectious diseases such as tuberculosis, and other type of cancer cells or tumors.
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- 2020
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17. A rua é nosso palco: Uma análise do projeto Teatro na Usina à luz das performances folkcomunicacionais e do desenvolvimento local em Bebelândia, Santa Rita (PB)
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Severino Alves de Lucena Filho and Ítalo Rômany de Carvalho Andrade
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local development ,performances ,folk-communication ,education ,Communication. Mass media ,P87-96 - Abstract
This paper analyses the folk-communication performances of project Teatro na Usina (Theater in the Plant), in the district of Bebelândia, Santa Rita city-PB, Brazil’s northeast. The aim is to check how the cultural initiative cooperates with the protagonism, empowerment and citizenship. The applicated method was a study case, during November/2016, including semi-structured interviews, with the intention of reveling the communities’ voices about the proposal and improvements caused by project. The cultural performances, after the conclusions, contribute to the local development, within social and educational aspects.
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- 2019
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18. Malacofauna diversity associated with distribution of Anomalocardia flexuosa (Linnaeus, 1767) (Mollusca: Bivalvia) on a tropical sandy beach
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Severino Adriano Oliveira Lima, Ana Júlia Rufino Freitas, and Humber Agrelli Andrade
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bivalve ,diversidade ,ecologia quantitativa ,macrofauna ,Science ,Biology (General) ,QH301-705.5 - Abstract
Knowledge about biological diversity is essential for the establishment of measures that lead to the protection of natural resources. Sandy beaches are areas of high diversity, with the malacofauna being an important component. Several mollusks are of great economic importance and the spatial distribution of these species on sandy beaches is linked to physical and biological factors. The aim of this study was to analyze the diversity of the malacofauna associated with Anomalocardia flexuosa distribution on a tropical sandy beach. Samples were collected bimonthly between April 2016 and February 2018 at 34 points distributed throughout a sandbar. The frequencies of occurrence of the species were calculated, and diversity indices were estimated and correlated with the densities of A. flexuosa. A total of 4,780 individuals from 11 species were obtained. The most frequent species were A. flexuosa and Neritina virginea. There were significant correlations between A. fleuxosa density and diversity, and overlap occurred between mollusks over the collection months and sites. Therefore, targeted catches for this species should also consider all other mollusks to mitigate future damage to malacofauna diversity in the region.
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- 2019
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19. Effects of gamma radiation on nanocomposite films of polycaprolactone with modified MCM-48
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Marcos Vinícius Paula, Leandro Araújo de Azevedo, Ivo Diego de Lima Silva, Glória Maria Vinhas, and Severino Alves Junior
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gamma radiation ,MCM-48 ,mechanical properties ,polycaprolactone ,Chemical technology ,TP1-1185 - Abstract
Abstract The aim of this investigation was to assess the effects of gamma radiation on nanocomposite films (NC films) formed by PCL (polycaprolactone) with MCM-48 nanoparticles (PCL/MCM-48) and PCL with MCM-48 NPs modified with (3-aminopropyl)triethoxysilane (APTES) (PCL/MCM-48-NH2). The nanocomposite films were obtained using the solvent casting method. After preparing the films, they were irradiated at 25 kGy in the presence of air and analyzed by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and scanning electron microscopy (SEM), transmission electronic microscopy (TEM), as well as for their mechanical properties. The exposure of NC films to gamma radiation at 25 kGy did not cause major changes in either thermal or mechanical properties such as tensile strength and modulus of elasticity. The results revealed that gamma radiation was a successful choice for the sterilization of these materials.
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- 2021
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20. Synthesis and Structural Characterization of an Amorphous and Photoluminescent Mixed Eu/Zr Coordination Compound, a Potential Marker for Gunshot Residues
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Ayla Roberta Borges Serra, Thiago Rui Casagrande, Juliana Fonseca de Lima, Marcelo Firmino de Oliveira, Severino Alves Júnior, Marcos de Oliveira Junior, and Osvaldo Antonio Serra
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mixed-metal coordination compound ,photoluminescence ,solid state NMR ,gun-shot-residue marker ,Science - Abstract
Hydrogels based on mixed zirconium/europium ions and benzene tricarboxylic acid were synthesized by hydrothermal reaction. A solid glass-like material is formed upon drying, showing strong reddish luminescence. The system was characterized by solid-state nuclear magnetic resonance, thermal analyses, and infrared spectroscopy. The results reveal the amorphous character of the structure and the presence of at least four types of binding modes between the metal oxide clusters and benzene tricarboxylic acid. On the other hand, thermogravimetric analysis (TGA) showed high thermal stability, with the material decomposing at temperatures higher than 500 °C. The combination of intense Eu3+ luminescence with large thermal stability makes this material a strong candidate for application as a luminescent red marker for gunshot residue (GSR). As proof of concept, we show the feasibility of this application by performing shooting tests using our compound as a GSR marker. After the shots, the residual luminescent particles could be visualized in the triggered cartridge, inner the muzzle of the firearm, and a lower amount on the hands of the shooter, using a UV lamp (λ = 254 nm). Remarkably, our results also show that the Eu3+ emission for the GSR is very similar to that observed for the original solid material. These characteristics are of huge importance since they provide a chance to use smaller amounts of the marker in the ammunition, lowering the costs of potential industrial manufacturing processes.
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- 2022
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21. E a gente ama esses bracinhos oferecidos: Folkcomunicação política na Campanha de vacinação contra a COVID-19 em Recife- PE.
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Giselle Gomes Souza and Severino Alves Lucena
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Communication. Mass media ,P87-96 - Abstract
O presente trabalho busca apontar o uso de estratégia folkcomunicacional política usando apropriação das mídias digitais pelos grupos populares, colocando em foco os processos informais de comunicação. O objetivo é verificar como a Prefeitura da Cidade do Recife utiliza a rede social para a interação com os leitores- internautas sobre o avanço com a vacinação contra a COVID-19 da população recifense. É na apropriação de elementos da cultura folk de massas que localizamos a utilização das redes sociais como veículo da folkcomunicação política pela Prefeitura da Cidade do Recife. Folkcomunicação política; Pandemia; Mídia.
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- 2021
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22. Distribuição vertical da Anomalocardia flexuosa (Linnaeus, 1767) (Bivalvia: Veneridae) na praia de Mangue Seco (Pernambuco, Brasil)
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Severino Adriano de Oliveira Lima, Humber Agrelli Andrade, Alfredo Leandro Borie Mojica, and Raniere Garcez Costa Sousa
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Berbigão ,Enterramento ,Macrofauna ,Praia arenosa ,Science ,Biology (General) ,QH301-705.5 - Abstract
O objetivo neste trabalho foi estudar a distribuição vertical da Anomalocardia flexuosa em uma praia arenosa do nordeste brasileiro. Foram obtidas 135 amostras em três meses no ano de 2015. Para testar a hipótese entre as densidades nas profundidades de até 5 cm (densidade 5) e entre 5 e 10 cm (densidade 10) foi realizado o teste t-Student. Modelos Lineares Generalizados foram aplicados para estimar a variável resposta densidade 10 com as explicativas espaciais, temporais e de abundância. Os resultados do melhor modelo foram interpolados por métodos geoestatísticos. As densidades foram significativamente maiores na densidade 5 (450 ind.m²) do que na densidade 10 (7 ind.m²). Entre os modelos avaliados, o com Binomial Negativa inflada de zeros foi o selecionado, sendo as predições interpoladas verossímeis com o observado, e as variáveis utilizadas foram: densidade 5, latitude, longitude (transformada) e mês (contínuo). A ocupação de A. flexuosa em camadas mais profundas do substrato pode decorrer de um enterramento acidental e ser atribuída a forçantes físicas, e não ser uma causa comportamental. Dessa maneira, o manejo sobre essa espécie deve considerar meios de captura que não penetrem o substrato além da camada preferencial, para assim não impactar outros organismos não alvo da pesca.
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- 2021
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23. Modelagem matemática aplicada às capturas das principais lagostas desembarcadas em Pernambuco
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Severino Adriano de Oliveira Lima and Humber Agrelli Andrade
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Defeso ,Lagosta espinhosa ,Modelo exponencial ,Palinuridae ,Science ,Biology (General) ,QH301-705.5 - Abstract
A extração de lagostas é considerada a atividade pesqueira mais atrativa economicamente na região Nordeste do Brasil. Neste trabalho, foram avaliadas as variações das capturas das lagostas Panulirus meripurpuratus (lagosta vermelha), Panulirus laevicauda (lagosta verde) e Scyllarides brasiliensis (lagosta sapata) no estado de Pernambuco, nos anos de 1999 a 2006, com intuito de verificar tendências nas produções mensais e a relação entre as capturas realizadas nos meses de defeso e na temporada de pesca. As capturas por temporada foram estudadas a partir de modelos exponenciais e análises de correlações. Modelos exponenciais foram significativos com coeficientes de determinação acima de 0,65 para lagosta vermelha em todos os anos e para a lagosta verde a partir de 2002, e descreveram os decaimentos das capturas do início até o final da temporada. A biomassa da lagosta verde mostrou um decaimento mais acentuado do que a da vermelha, possivelmente porque o coeficiente de capturabilidade seria maior. Já para a lagosta sapata, os modelos tiveram valores dos coeficientes de determinação sempre inferiores a 0,40. A correlação entre a captura legal e ilegal foi significativa apenas para a lagosta verde e apresentou tendência positiva. A magnitude inicial das capturas para a lagosta vermelha com valores abaixo de 25 toneladas no início da temporada de pesca pode ser um indício alarmante, enquanto para lagosta verde, esse valor pode ser de 10 toneladas. Estudos com modelos de excedente de produção são necessários para melhor avaliar os estoques e verificar a hipótese de que a lagosta verde teria um coeficiente de capturabilidade maior que o da lagosta vermelha.
- Published
- 2021
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24. Global subterranean estuaries modify groundwater nutrient loading to the ocean
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Wilson, Stephanie J, Moody, Amy, McKenzie, Tristan, Cardenas, M Bayani, Luijendijk, Elco, Sawyer, Audrey H, Wilson, Alicia, Michael, Holly A, Xu, Bochao, Knee, Karen L, Cho, Hyung‐Mi, Weinstein, Yishai, Paytan, Adina, Moosdorf, Nils, Chen, Chen‐Tung Aurthur, Beck, Melanie, Lopez, Cody, Murgulet, Dorina, Kim, Guebuem, Charette, Mathew A, Waska, Hannelore, Ibánhez, J Severino P, Chaillou, Gwénaëlle, Oehler, Till, Onodera, Shin‐ichi, Saito, Mitsuyo, Rodellas, Valenti, Dimova, Natasha, Montiel, Daniel, Dulai, Henrietta, Richardson, Christina, Du, Jinzhou, Petermann, Eric, Chen, Xiaogang, Davis, Kay L, Lamontagne, Sebastien, Sugimoto, Ryo, Wang, Guizhi, Li, Hailong, Torres, Américo I, Demir, Cansu, Bristol, Emily, Connolly, Craig T, McClelland, James W, Silva, Brenno J, Tait, Douglas, Kumar, BSK, Viswanadham, R, Sarma, VVSS, Silva‐Filho, Emmanoel, Shiller, Alan, Lecher, Alanna, Tamborski, Joseph, Bokuniewicz, Henry, Rocha, Carlos, Reckhardt, Anja, Böttcher, Michael Ernst, Jiang, Shan, Stieglitz, Thomas, Gbewezoun, Houégnon Géraud Vinel, Charbonnier, Céline, Anschutz, Pierre, Hernández‐Terrones, Laura M, Babu, Suresh, Szymczycha, Beata, Sadat‐Noori, Mahmood, Niencheski, Felipe, Null, Kimberly, Tobias, Craig, Song, Bongkeun, Anderson, Iris C, and Santos, Isaac R
- Subjects
Earth Sciences ,Oceanography - Abstract
Abstract: Terrestrial groundwater travels through subterranean estuaries before reaching the sea. Groundwater‐derived nutrients drive coastal water quality, primary production, and eutrophication. We determined how dissolved inorganic nitrogen (DIN), dissolved inorganic phosphorus (DIP), and dissolved organic nitrogen (DON) are transformed within subterranean estuaries and estimated submarine groundwater discharge (SGD) nutrient loads compiling > 10,000 groundwater samples from 216 sites worldwide. Nutrients exhibited complex, nonconservative behavior in subterranean estuaries. Fresh groundwater DIN and DIP are usually produced, and DON is consumed during transport. Median total SGD (saline and fresh) fluxes globally were 5.4, 2.6, and 0.18 Tmol yr−1 for DIN, DON, and DIP, respectively. Despite large natural variability, total SGD fluxes likely exceed global riverine nutrient export. Fresh SGD is a small source of new nutrients, but saline SGD is an important source of mostly recycled nutrients. Nutrients exported via SGD via subterranean estuaries are critical to coastal biogeochemistry and a significant nutrient source to the oceans.
- Published
- 2024
25. Políticas e estratégias de comunicação na comunidade Padre Hildon Bandeira, João Pessoa-PB, Brasil: sobre micro-revoluções cotidianas
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Severino Alves de Lucena Filho and Juliana Freire Bezerra
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folk-activism ,communication ,citizenship ,local development ,Communication. Mass media ,P87-96 - Abstract
Este trabalho teve como objetivo analisar o papel desempenhado por ativistas-folk na comunidade rurbana Padre Hildon Bandeira, situada em João Pessoa-PB, sob a perspectiva do Desenvolvimento Local e da Teoria da Folkcomunicação. Do estudo, evidenciamos em que medida os atores sociais contribuem para a nutrição de redes cívicas e de comunicação, criando oportunidades, democratizando socialmente a comunidade e estabelecendo relações de solidariedade e confiança, bem como angariando benefícios sociais junto aos poderes públicos.
- Published
- 2018
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26. Associação dos genótipos da ACTN3 aos indicadores de desempenho em atletas juvenis da natação brasileira especialistas em curtas distâncias
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Severino Albuquerque Neto, Gislane Ferreira Melo, Glauber Branco Silva, Thiago Santos Rosa, Sandro Soares Almeida, Marcos Pereira Santos, and Alexandre Sérgio Silva
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Medicine ,Sports medicine ,RC1200-1245 - Abstract
Foi objetivo da pesquisa identificar a frequência genotípica da ACTN3 e associa-la ao índice técnico (IT) e ao status de elite em 98 atletas juvenis de natação (16,80 ± 0,63 anos) especialistas em curtas distâncias (≤ 200m). Um grupo controle (GC) com 101 escolares não-atletas (16,52 ± 0,94 anos) foi incluído nas comparações. Os grupos foram analisados sem divisão por sexo. Os atletas foram divididos pelas experiências competitivas em elite (internacionais, n = 15) e sub-elite (nacionais, n = 83). Não verificou-se diferenças significativas (X2) na frequência genotípica entre atletas sub-elite e GC. Os atletas de elite apresentaram supremacia do genótipo RX (60,0%), baixa frequência do genótipo RR (13,3%), supremacia do alelo X (54,2%) e da adição RX+XX (86,7%). O ajuste das frequências genotípicas pelo quartil superior (QS) do IT revelou que os atletas com genótipos RR+RX apresentaram maior pontuação média (820,6 ± 40,0) quando comparados aos atletas XX (806,7 ± 34,8). Atletas de elite do grupo QS (RR+RX) apresentaram valores médios do IT ainda mais expressivos (853,9 ± 31,3). Os genótipos da ACTN3 demonstraram boa associação aos fenótipos da força/potência apenas entre os atletas identificados nos mais altos níveis de desempenho.
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- 2018
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27. EVLearn: Extending the CityLearn Framework with Electric Vehicle Simulation
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Fonseca, Tiago, Ferreira, Luis, Cabral, Bernardo, Severino, Ricardo, Nweye, Kingsley, Ghose, Dipanjan, and Nagy, Zoltan
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Computer Science - Multiagent Systems ,Electrical Engineering and Systems Science - Systems and Control - Abstract
Intelligent energy management strategies, such as Vehicle-to-Grid (V2G) and Grid-to-Vehicle (G2V) emerge as a potential solution to the Electric Vehicles' (EVs) integration into the energy grid. These strategies promise enhanced grid resilience and economic benefits for both vehicle owners and grid operators. Despite the announced prospective, the adoption of these strategies is still hindered by an array of operational problems. Key among these is the lack of a simulation platform that allows to validate and refine V2G and G2V strategies. Including the development, training, and testing in the context of Energy Communities (ECs) incorporating multiple flexible energy assets. Addressing this gap, first we introduce the EVLearn, a simulation module for researching in both V2G and G2V energy management strategies, that models EVs, their charging infrastructure and associated energy flexibility dynamics; second, this paper integrates EVLearn with the existing CityLearn framework, providing V2G and G2V simulation capabilities into the study of broader energy management strategies. Results validated EVLearn and its integration into CityLearn, where the impact of these strategies is highlighted through a comparative simulation scenario., Comment: 10 pages, 7 figures, 3 tables, 11 equations
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- 2024
28. EnergAIze: Multi Agent Deep Deterministic Policy Gradient for Vehicle to Grid Energy Management
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Fonseca, Tiago, Ferreira, Luis, Cabral, Bernardo, Severino, Ricardo, and Praca, Isabel
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Computer Science - Multiagent Systems ,Computer Science - Artificial Intelligence - Abstract
This paper investigates the increasing roles of Renewable Energy Sources (RES) and Electric Vehicles (EVs). While indicating a new era of sustainable energy, these also introduce complex challenges, including the need to balance supply and demand and smooth peak consumptions amidst rising EV adoption rates. Addressing these challenges requires innovative solutions such as Demand Response (DR), energy flexibility management, Renewable Energy Communities (RECs), and more specifically for EVs, Vehicle-to-Grid (V2G). However, existing V2G approaches often fall short in real-world adaptability, global REC optimization with other flexible assets, scalability, and user engagement. To bridge this gap, this paper introduces EnergAIze, a Multi-Agent Reinforcement Learning (MARL) energy management framework, leveraging the Multi-Agent Deep Deterministic Policy Gradient (MADDPG) algorithm. EnergAIze enables user-centric and multi-objective energy management by allowing each prosumer to select from a range of personal management objectives, thus encouraging engagement. Additionally, it architects' data protection and ownership through decentralized computing, where each prosumer can situate an energy management optimization node directly at their own dwelling. The local node not only manages local energy assets but also fosters REC wide optimization. The efficacy of EnergAIze was evaluated through case studies employing the CityLearn simulation framework. These simulations were instrumental in demonstrating EnergAIze's adeptness at implementing V2G technology within a REC and other energy assets. The results show reduction in peak loads, ramping, carbon emissions, and electricity costs at the REC level while optimizing for individual prosumers objectives., Comment: 6 pages, 6 figures, 2 tables
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- 2024
29. Universal Cold RNA Phase Transitions
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Rissone, Paolo, Severino, Aurelien, Pastor, Isabel, and Ritort, Felix
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Quantitative Biology - Biomolecules ,Physics - Biological Physics ,Quantitative Biology - Quantitative Methods ,Statistics - Methodology - Abstract
RNA's diversity of structures and functions impacts all life forms since primordia. We use calorimetric force spectroscopy to investigate RNA folding landscapes in previously unexplored low-temperature conditions. We find that Watson-Crick RNA hairpins, the most basic secondary structure elements, undergo a glass-like transition below $\mathbf{T_G\sim 20 ^{\circ}}$C where the heat capacity abruptly changes and the RNA folds into a diversity of misfolded structures. We hypothesize that an altered RNA biochemistry, determined by sequence-independent ribose-water interactions, outweighs sequence-dependent base pairing. The ubiquitous ribose-water interactions lead to universal RNA phase transitions below $\mathbf{T_G}$, such as maximum stability at $\mathbf{T_S\sim 5 ^{\circ}}$C where water density is maximum, and cold denaturation at $\mathbf{T_C\sim-50^{\circ}}$C. RNA cold biochemistry may have a profound impact on RNA function and evolution., Comment: Main: 21 pages, 5 figures. Supplementary Info: 29 pages, 10 figures, 6 tables
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- 2024
30. Spontaneous assembly of condensate networks during the demixing of structured fluids
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Morimitsu, Yuma, Browne, Christopher A., Liu, Zhe, Severino, Paul G., Gopinadhan, Manesh, Sirota, Eric B., Altintas, Ozcan, Edmond, Kazem V., and Osuji, Chinedum O.
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Condensed Matter - Soft Condensed Matter ,Condensed Matter - Disordered Systems and Neural Networks - Abstract
Liquid-liquid phase separation, whereby two liquids spontaneously demix, is ubiquitous in industrial, environmental, and biological processes. While isotropic fluids are known to condense into spherical droplets in the binodal region, these dynamics are poorly understood for structured fluids. Here, we report the novel observation of condensate networks, which spontaneously assemble during the demixing of a mesogen from a solvent. Condensing mesogens form rapidly-elongating filaments, rather than spheres, to relieve distortion of a simultaneously-forming internal smectic mesophase. As filaments densify, they collapse into bulged discs, lowering the elastic free energy. Additional distortion is relieved by retraction of filaments into the bulged discs, which are straightened under tension to form a ramified network. Understanding and controlling these dynamics may provide new avenues to direct pattern formation or template materials.
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- 2024
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31. Diversidade das pescarias realizadas com rede de emalhar em um estuário tropical do nordeste do Brasil
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Severino Adriano Oliveira Lima, Humber Agrelli Andrade, Marcondes Agostinho Gonzada Junior, and Donovan Filipe Henrique Pinto
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Pesca estuarina ,Pequenos pelágicos ,Engraulidae ,Opisthonema oglinum ,Science ,Biology (General) ,QH301-705.5 - Abstract
O objetivo neste trabalho foi estudar a diversidade da ictiofauna capturada com a rede de emalhar mais utilizada no estado de Pernambuco. No total foram realizadas 14 coletas no Canal de Santa Cruz (CSC) entre os meses de julho de 2013 e junho de 2014. As amostras foram obtidas com rede de emalhar de malha de 30 mm. Os peixes capturados foram retirados e separados na posição margem e centro, e na posição vertical da rede (superior, meio e inferior). Quanto à frequência de ocorrência, as espécies foram classificadas como comuns, acessórias ou ocasionais. Foram realizadas análises de diversidade alfa e beta. No total foram capturadas 19 espécies, sendo Opisthonema oglinum e Anchovia clupeoides as únicas constantes. As diversidades alfa estimadas não apresentaram diferenças significativas nos estratos temporais e espaciais. Na diversidade beta dois grupos se distinguiram, sendo que no maior ocorreu geralmente grandes abundâncias de O. oglinum. A rede avaliada foi eficiente para a espécie alvo O. oglinum e as capturas de outras espécies corresponderam a menos de 13% da icitiofauna já encontrada no CSC. Portanto, medidas de gestão que visem restringir o uso do petrecho para a proteção da diversidade, considerando a sazonalidade e espacialidade no canal, não são recomendadas.
- Published
- 2021
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32. The nutritional value of gliricidia in different fed forms: a systematic review/O valor nutricional da gliric dia em diferentes formas de alimentacao: uma revisao sistematica
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da Silva, Pedro Henrique Ferreira, de Medeiros, Geovergue Rodrigues, de Macedo Carvalho, Chrislanne Barreira, Cavalcante, Iara Tamires Rodrigues, dos Santos, Severino Guilherme Caetano Goncalves, da Silva Neves, Romildo, Ribeiro, Neila Lidiany, Costa, Jose Henrique Souza, and Sales-Silva, Tafnes Bernardo
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- 2024
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33. Voluntad e interés del estudiante universitario: el vínculo entre la motivación en la investigación y la responsabilidad social universitaria
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Severino-González, Pedro, Sarmiento-Peralta, Giusseppe, Guerrero-Miranda, Mary, and Calderón-Morales, Walter
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- 2024
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34. Response assessment in pediatric neurooncology (RAPNO) criteria revisited: a practical navigation guide for neuroradiologists
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Geraldo, Ana Filipa, Maldonado, Francisco, Severino, Mariasavina, Mankad, Kshitij, Dahmoush, Hisham, Soares, Bruno, Rugilo, Carlos, and Rossi, Andrea
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- 2024
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35. Synthesis and characterization of a new biomaterial-based scaffold based on chitosan and cashew gum: an inquiry into structural and physical properties
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de Andrade, Lucas R. Melo, Mota, Wanessa S., de Melo Barbosa, Raquel, Cardoso, Juliana C., Andrade, Luciana N., Pereira, Matheus M., de Albuquerque Junior, Ricardo L. C., Naveros, Beatriz C., Souto, Eliana B., and Severino, Patrícia
- Published
- 2024
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36. Advanced imaging techniques and non-invasive biomarkers in pediatric brain tumors: state of the art
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Iacoban, Catalin George, Ramaglia, Antonia, Severino, Mariasavina, Tortora, Domenico, Resaz, Martina, Parodi, Costanza, Piccardo, Arnoldo, and Rossi, Andrea
- Published
- 2024
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37. Unraveling the complexities of a highly heterogeneous aquifer under convergent radial flow conditions
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Brunetti, Guglielmo Federico Antonio, Maiolo, Mario, Fallico, Carmine, and Severino, Gerardo
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- 2024
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38. Learning Outcomes and Training Satisfaction: A Case Study of Blended Customization in Professional Training
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Torre, Sara, Ulloa Severino, Antonio, and Ligorio, Maria Beatrice
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- 2024
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39. Strategy for an early simultaneous introduction of four-pillars of heart failure therapy: results from a single center experience
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Severino, Paolo, D’Amato, Andrea, Prosperi, Silvia, Mariani, Marco Valerio, Myftari, Vincenzo, Labbro Francia, Aurora, Cestiè, Claudia, Tomarelli, Elisa, Manzi, Giovanna, Birtolo, Lucia Ilaria, Marek-Iannucci, Stefanie, Maestrini, Viviana, Mancone, Massimo, Badagliacca, Roberto, Fedele, Francesco, and Vizza, Carmine Dario
- Published
- 2024
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40. Antimicrobial and antibiofilm activities of Brazilian organic honey against oral microorganisms
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Romário-Silva, Diego, Franchin, Marcelo, Alencar, Severino Matias, Bueno-Silva, Bruno, de Cássia Orlandi Sardi, Janaína, da Silva, Andréa Cristina Barbosa, Cruz-Vieira, Fabiane, da Silva, Priscila Vieira, and Rosalen, Pedro Luiz
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- 2024
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41. Selectivity of a fishing gear used in the catch of Anomalocardia flexuosa in the Northeast of Brazil
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Severino Adriano de Oliveira Lima, Humber Agrelli Andrade, and Alfredo Olivera Gálvez
- Subjects
coastal ecosystem ,mangue seco beach ,Benthic macrofauna ,Anomalocardia brasiliana ,fishing ,dredge ,Agriculture ,Agriculture (General) ,S1-972 - Abstract
ABSTRACT: A type of dredge was introduced as fishing gear along the extractive bank of Mangue Seco - PE from which the largest annual catch of Anomalocardia flexuosa in the world is extracted. This study was carried out with the objective of estimating the selectivity of the new fishing gear and quantitatively evaluating the length classes most compromised by the catches, especially considering 20 mm as the reference value. Specimens larger than this size are most likely to be mature. For the selectivity estimation, the methodology using codends (16 or 20 mm) and small meshed cover (2 mm) was used. To estimate the selectivity parameters, a logistic regression and the Bayesian approach were used. The transition between the state in which the specimen is invulnerable to the fishing gear and vulnerable occurs between 10 and 18 mm, using a 16 mm mesh, and using a 20 mm mesh, this transition is between 14 and 20 mm. Dredgers with 16 mm and 20 mm mesh compromise a large proportion of specimens smaller than 20 mm. If the intention is to protect this part of the population, measures such as total restriction of the 16 mm mesh and use of the 20 mm mesh should be necessary only in the months of less catching incidences, or increasing the mesh to 25 mm.
- Published
- 2020
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42. Cytotoxic Activity of the Mesoionic Compound MIH 2.4Bl in Breast Cancer Cell Lines
- Author
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Luciana Amaral de Mascena Costa, Ashlyn C Harmon, Alvaro Aguiar Coelho Teixeira, Filipe Cássio Silva de Lima, Silvany de Sousa Araújo, Fabio Del Piero, Helivaldo Diógenes da Silva Souza, Petrônio Filgueiras de Athayde Filho, Severino Alves Junior, Maria de Mascena Diniz Maia, Aurea Wischral, Manoel Adrião Gomes Filho, and J Michael Mathis
- Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
In this work, we report the synthesis of a new 1,3-thiazolium-5-thiolate derivative of a mesoionic compound (MIH 2.4Bl) and the characterization of its selective cytotoxicity on a panel of breast cancer cells lines. The cytotoxic effect of MIH 2.4Bl on breast cancer cell lines was determined by XTT and crystal violet assays, flow cytometry analysis, electron microscopy characterization, and terminal deoxynucleotidyl transferase (TdT) deoxyuridine triphosphate (dUTP) nick end labeling (TUNEL) apoptosis assays. As determined using XTT cell growth and survival assays, MIH 2.4Bl exhibited growth inhibition activity on most breast cancer cell lines tested, compared with normal human mammary epithelial cells. Three breast cancer cell lines (MCF-7, T-47D, and ZR-75-1) showed a more potent sensitivity index to growth inhibition by MIH 2.4Bl than the other breast cancer cell lines. Interestingly, these 3 cell lines were derived from tumors of Luminal A origin and have ER (estrogen receptor), PR (progesterone receptor), and HER2 (human epidermal growth factor receptor 2) positive expression. Additional analysis of cytotoxicity mediated by MIH 2.4Bl was performed using the MCF-7 cell line. MCF-7 cells displayed both time- and dose-dependent decreases in cell growth and survival, with a maximum cytotoxic effect observed at 72 and 96 hours. The MCF-7 cells were also characterized for cell cycle changes upon treatment with MIH 2.4Bl. Using flow cytometry analysis of cell cycle distribution, a treatment-dependent effect was observed; treatment of cells with MIH 2.4Bl increased the G2/M population to 34.2% compared with 0.1% in untreated (control) cells. Ultrastructural analysis of MFC-7 cells treated with MIH 2.4Bl at 2 different concentrations (37.5 and 75 μM) was performed by transmission electron microscopy. Cells treated with 37.5 μM MIH 2.4Bl showed morphologic changes beginning at 6 hours after treatment, while cells treated with 75 μM showed changes beginning at 3 hours after treatment. These changes were characterized by an alteration of nuclear morphology and mitochondrial degeneration consistent with apoptotic cell death. Results of a TUNEL assay performed on cells treated for 96 hours with MIH 2.4Bl supported the observation of apoptosis. Together, these results suggest that MIH 2.4Bl is a promising candidate for treating breast cancer and support further in vitro and in vivo investigation.
- Published
- 2020
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43. A Internet como Instrumento de Pesquisa e de Aprendizagem: uma Análise a partir do Ensino de Geografia
- Author
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Severino Alves Coutinho
- Subjects
Geografia ,Internet ,Aprendizagem. ,Geography (General) ,G1-922 - Abstract
Este artigo está pautado num estudo voltado ao ensino de Geografia e o uso da internet como fonte de informação e de pesquisa, tendo em vista sua acessibilidade enquanto interface tecnológica importante para o desenvolvimento de atividades pedagógicas que permita a sua utilização não apenas como mera atratividade, mas, sobretudo, como veículo de comunicação que expressa em tempo real uma diversidade de imagens e informações que podem subsidiar o planejamento e motivar docentes e discentes, gerando mais qualidade no processo de ensino aprendizagem. Ademais, enquanto recurso didático tecnológico, a internet oferece um diversificado fluxo de trabalhos acadêmicos em formato digital, possibilitando a leitura e a reflexão, bem como ainda servindo como suporte teórico para estudos propostos pela disciplina. Sob esse viés de análise, esse artigo foi estruturado a partir de uma pesquisa de campo realizada na Escola Estadual Professora Ocila Bezerril, no município de Montanhas – RN, onde foram aplicados questionários aos alunos do 1º ano do Ensino Médio, buscando verificar se a internet tem sido utilizada como instrumento que proporciona aprendizagem no ensino de Geografia, bem como se os docentes têm orientado estudos que contemplem o uso dessa tecnologia em sala de aula. Pela análise dos dados, constatou-se que apesar dos alunos serem a favor da inserção deste recurso no contexto escolar, nem todos os educadores têm como prática lecionar Geografia em consonância com a dinâmica interativa da internet.
- Published
- 2020
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44. Zoneamento da área extrativista mais produtiva da Anomalocardia flexuosa (Linnaeus, 1767) (Mollusca: Bivalvia) no mundo
- Author
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Severino Adriano Oliveira Lima and Humber Agrelli Andrade
- Subjects
Anomalocardia brasiliana ,Densidade ,Distribuição ,Ecossistema costeiro ,Macrofauna ,Science ,Biology (General) ,QH301-705.5 - Abstract
A praia de Mangue Seco, no estado de Pernambuco, é um local com grande quantidade de ecossistemas e se destaca principalmente pela captura da espécie Anomalocardia flexuosa. Neste trabalho foi proposto um zoneamento dessa praia de acordo com as características mais expressivas e também considerando as densidades da Anomalocardia flexuosa. No delineamento da região foram considerados primeiramente os efeitos das águas circundantes e a proximidade da linha de praia; assim, três principais estratos de localização foram avaliados (borda, interior costa e interior mar), além de estratos secundários com divisões latitudinais e longitudinais. No total foram obtidas 176 amostras em campanhas realizadas no ano de 2015. As médias das densidades foram maiores no setor interior costa em todas as campanhas. As zonas localizadas próximas a estuários pareceram mais propícias ao estabelecimento da espécie quando comparadas a locais com maior interferência marinha. Foi possível diferenciar, principalmente, quatro estratos de localização de acordo com as características morfodinâmicas e as densidades da Anomalocardia flexuosa. O primeiro estrato e o mais abundante seria o interior costa, o segundo o interior mar e o estrato borda seria dividido em dois substratos, um mais afastado da linha de praia e outro mais próximo às saídas de foz.
- Published
- 2018
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45. Multifunctional System Polyaniline-Decorated ZIF‑8 Nanoparticles as a New Chemo-Photothermal Platform for Cancer Therapy
- Author
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Janine S. F. Silva, José Y. R. Silva, Gilberto F. de Sá, Silvany S. Araújo, Manoel A. Gomes Filho, Célia M. Ronconi, Thiago C. Santos, and Severino A. Júnior
- Subjects
Chemistry ,QD1-999 - Published
- 2018
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46. A Queijadinha de Dona Marieta em São Cristóvão/SE no Contexto do Folkturismo como Estratégia para o Desenvolvimento Local
- Author
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Flávio Menezes Santana and Severino Alves de Lucena Filho
- Subjects
folkturismo ,queijadinha ,são cristóvão ,tourism. ,Communication. Mass media ,P87-96 - Abstract
A relação estreita entre mídia, turismo e cultura popular expandiu o olhar dos discípulos de Luiz Beltrão, que a partir da Folkcomunicação, teoria genuinamente brasileira, observaram a apropriação dos bens culturais como atrações turística através de meios de informação e da comunicação. Elementos da produção local como manifestações culturais, religiosas e gastronômicas, por exemplo, passam a se tornar produtos vendáveis que impactam principalmente na economia da região. Dessa forma, esta pesquisa tem por base apontar a Queijada de Dona Marieta como elemento folkturistico na cidade de São Cristóvão, como estratégia para o desenvolvimento local. A contribuição deste debate consiste em fortalecer o reconhecimento da teoria beltraniana, bem como expandir os olhares dos discípulos de Luiz Beltrão.
- Published
- 2018
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47. Marca Paixão de Cristo de nova Jerusalém: uma análise na perspectiva do Folkmarketing e desenvolvimento local em Fazenda Nova/PE
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Simone Maria da Conceição and Severino Alves de Lucena Filho
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folkmarketing ,passion of christ ,marketing communication ,local development ,Communication. Mass media ,P87-96 - Abstract
Folkmarketing becomes extremely current when it comes to market-oriented marketing and horizontal marketing because it aims to communicate and satisfy consumers' needs and desires through the use of appropriations of popular culture. The article proposes to present the results of the analysis of the brand New Passion of Christ as a folkmarketing strategy for the local development of Fazenda Nova, Brejo district of Madre de Deus, Pernambuco. For this, bibliographical, documentary and field researches are used, qualitative method in semistructured questionnaire and studies based on authors such as Luiz Beltrão, Severino Lucena, Daniel Galindo and Paulo de Jesus. The results present the strategies of Folkmarketing as a great differential in marketing communication in front of the promotion of the local culture, potentializing the economy and contributing to the Local Development process.
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- 2017
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48. Neocoronelismo e o discurso popular no Nordeste: uma análise folkcomunicacional nas eleições de 2014 na Paraíba
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Ítalo Rômany de Carvalho Andrade and Severino Alves de Lucena Filho
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coronelism ,folkcommunication ,neocoronelism ,Communication. Mass media ,P87-96 - Abstract
This article examines, through Folkcommunication, the historical and social process of the coronelist regime during the First Republic (1889-1930) in Brazil, and its connotations in present time. The aim was to analyze folkcommunicational and neocoronelist discursive manifestations practiced by Cássio Cunha Lima (from the Brazilian Social Democratic Party, PSDB), during the elections for the governor of the State of Paraíba in 2014, and published at the internet portal of the coalition A Vontade do Povo (People’s Will, in free translation). It is concluded that Coronelism is still a current practice in our country, mastering the power no more by violence, but by the relation between personality and charisma of the politician and the population.
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- 2017
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49. A Ginzburg-Landau approach to the vortex-domain wall interaction in superconductors with nematic order
- Author
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Severino, Ramiro, Mininni, Pablo, Fradkin, Eduardo, Bekeris, Victoria, Pasquini, Gabriela, and Lozano, Gustavo
- Subjects
Condensed Matter - Superconductivity - Abstract
In this work we study the interaction between vortices and nematic domain walls within the framework of a Ginzburg Landau approach. The free energy of the system is written in terms of a complex order parameter characteristic of $s$-wave superconductivity and a real (Ising type) order parameter associated to nematicity. The interaction between both order parameters is described by a biquadratic and a trilinear derivative term. To study the effects of these interactions we solve the time-dependent dissipative Ginzburg Landau equations using a highly performant pseudospectral method by which we calculate the trajectories of a vortex that, for different coupling parameters, is either attracted or repelled by a wall, as well as of the wall dynamics. We show that despite its simplicity, this theory displays many phenomena observed experimentally in Fe-based superconductors. In particular we find that the sign of the biquadratic term determines the attractive (pining) or repulsive (antipining) character of the interaction, as observed in FeSe and BaFeCoAs compounds respectively. The trilinear term is responsible for the elliptical shape of vortex cores as well as for the orientation of the axes of the ellipses and vortex trajectories with respect to the axes of the structural lattice. For the case of pining, we show that the vortex core is well described by a heart-shaped structure in agreement with STM experiments performed in FeSe.
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- 2024
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50. Analysis of genetic divergence in Psidium cattleyanum Sabine accessions based on morphological fruit descriptors
- Author
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da Silva Santos, Paulo César, Gallo, Ricardo, Santos, Marcone Moreira, Nonato, Erika Rayra Lima, da Silva Santos, Ramon, Lira Júnior, José Severino, and Batista, Diego Silva
- Published
- 2024
- Full Text
- View/download PDF
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