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Mosquito vectors such as Aedes spp. are responsible for the transmission of arboviruses that have a major impact on public health. Therefore, it is necessary to search for ways to control these insects, avoiding the use of conventional chemical insecticides that are proven to be toxic to nature. In the last years, there has been growing evidence for the potential of silver nanoparticles (AgNPs) to be ecologically benign alternatives to the commercially available chemical insecticides against vector-borne diseases. Natural seaweed extracts contain metabolites such as polyphenols, terpenoids, and alkaloids. These compounds act as reducing agents and stabilizers to synthesize biogenic AgNPs. The green synthesis of AgNPs has advantages over other methods, such as low cost and sustainable biosynthesis. In the perspective of using AgNPs in the development of novel insecticides for vector control, this review deals with the eco-friendly synthesis of AgNPs through seaweed extracts as reducing and stabilizing agents. In addition, assessment of toxicity of these nanomaterials in non-target species is discussed.

Problema: O Currículo Baseado em Competências para a Medicina de Família e Comunidade (MFC) aponta o desenvolvimento de habilidades em docência como essencial para a formação de um médico de família e comunidade. O Programa de Residência Médica da Universidade Federal do Rio Grande do Norte (UFRN) conta com a preceptoria de alunos do internato de MFC como experiência desenvolvida durante a residência. Foi observado o caráter singular das práticas realizadas na realidade da Atenção Primária à Saúde (APS), devido à grande demanda assistencial da comunidade, sendo necessária a busca do equilíbrio entre o ensino e a assistência. A proposta da equipe foi o uso de metodologias ativas (MAs) de ensino para otimizar a preceptoria em MFC e desenvolver nos alunos habilidades de autonomia no seu processo de aprendizagem. Método: A experiência relatada focou na inserção de MAs durante o internato em MFC. Foram utilizadas duas MAs para a criação de um livro digital sobre temas da APS, sendo elas a Aprendizagem Baseada em Projetos (ABP) e a sala de aula invertida, por meio da criação de um ebook voltado para a APS. Resultados: A equipe produziu e discutiu quatorze capítulos em seis meses de atividades. Os benefícios incluíram o desenvolvimento de habilidades essenciais, a otimização do tempo de estudo e a construção de um produto científico. Os resultados confirmam a relevância das MAs na formação médica, corroborando estudos anteriores. Foi observada a viabilidade do uso das MAs no internato de MFC, enfatizando a importância da Residência Médica no processo de ensino. Conclusão: O projeto serve como exemplo para outras instituições, visando formar médicos autônomos e críticos, em conformidade com as Diretrizes Curriculares Nacionais (DCNs).

Introduction Syringomyelia is a chronic disease characterized by the presence of intramedullary cavity. Chiari malformation (CM) and basilar impression (BI) are conditions usually associated with syringomyelia. Its prevalence has wide geographical variation, being higher in the Northeast of Brazil, making it relevant to study the subject in this region.

AimTo evaluate in vitro the effect of laser photobiomodulation (PBM) combined or not with 30-nm hydroxyapatite nanoparticles (HANp), on the osteogenic differentiation of human umbilical cord mesenchymal stem cells (hUC-MSCs) by morphometric analysis using artificial intelligence programs (TensorFlow and ArcGIS).MethodsUC-MSCs were isolated and cultured until 80% confluence was reached. The cells were then plated according to the following experimental groups: G1 -control (DMEM), G2 -BMP-2, G3 -BMP-7, G4 -PBM (660 nm, 10 mW, 2.5 J/cm2, spot size of 0.08 cm2), G5 -HANp, G6 -HANp + PBM, G7 -BMP-2 + PBM, and G8 -BMP-7 + PBM. The MTT assay was used to analyze cell viability at 24, 48 and 72 h. Osteogenic differentiation was assessed by Alizarin Red staining after 7, 14 and 21 days. For morphometric analysis, areas of osteogenic differentiation (pixel2) were delimited by machine learning using the TensorFlow and ArcGIS 10.8 programs.ResultsThe results of the MTT assay showed high rates of cell viability and proliferation in all groups when compared to control. Morphometric analysis revealed a greater area of osteogenic differentiation in G5 (HANp = 142709,33±36573,39) and G6 (HANp + PBM = 125452,00±24226,95) at all time points evaluated.ConclusionIt is suggested that HANp, whether combined with PBM or not, may be a promising alternative to enhance the cellular viability and osteogenic differentiation of hUC-MSCs.

O objetivo do artigo é discutir a importância do pensamento complexo, da multidisciplinariedade e da epistemologia dialética para a criação, a avaliação e o desenvolvimento de normas ou de instituições jurídicas ambientais. O método científico utilizado na pesquisa será o da argumentação sistemática, que envolve a análise conceitual das ideias do tema, com seu caráter exploratório, qualitativo e de revisão bibliográfica. Conclui-se que o pensamento complexo aliado à epistemologia dialética e ao conhecimento multidisciplinar são indispensáveis à tomada de consciência individual e social dos desafios que movem a humanidade à sua sobrevivência na Terra. Em suma, depreendeu-se que somente com uma interpretação linear e mecânica em relação à lei ou à política ambiental não se alcançará êxito na defesa jurídica do equilíbrio ecológico do meio ambiente.

In this work, poly (vinyl alcohol) (PVA) was employed to produce a Mesoporous Composition of Matter-48 Modified (MCM-48-M or MCM-48-PVA). After surface modification, MCM-48-M was used to produce nanocomposite (NC) films with polycaprolactone (PCL) as a matrix at room temperature. PCL and MCM-48 nanoparticles (NPs) were chosen due to their great biocompatibility and low toxicity. However, MCM-48-M is more compatible with PCL than MCM-48. NC films were sterilized by gamma radiation with a dose of 25 kGy and characterized by experimental techniques to investigate their chemical, mechanical (tensile) and thermal properties. Scanning electron microscopy (SEM) and transmission electronic microscopy (TEM) results indicated that MCM-48-M exhibited a random distribution in the PCL matrix. The PCL chemical structure was preserved in NC films as described by Fourier transform infrared (FT-IR) spectroscopy as well as the tensile and thermal properties of NC films. FT-IR and thermogravimetric analysis (TGA) results showed surface modification. X-ray diffraction (XRD) and differential scanning calorimetry (DSC) showed that crystalline symmetries were preserved and the crystallinity of NC films had small variations in all samples before and after irradiation, respectively. But, our results did not indicate major changes showing that this method is successful for the sterilization of PCL/MCM-48-PVA NC films.

We study the microscopic mechanism controlling the interplay between local charge and local spin fluctuations in correlated electron systems via a thorough investigation of the generalized on-site charge susceptibility of several fundamental many-electron models, such as the Hubbard atom, the Anderson impurity model, and the Hubbard model. By decomposing the numerically determined generalized susceptibility in terms of physically transparent single-boson exchange processes, we unveil the microscopic mechanisms responsible for the breakdown of the self-consistent many-electron perturbation expansion. In particular, we unambiguously identify the origin of the significant suppression of its diagonal entries in (Matsubara) frequency space and the slight increase of the off-diagonal ones which cause the breakdown. The suppression effect on the diagonal elements originates directly from the electronic scattering on local magnetic moments, reflecting their increasingly longer lifetime as well as their enhanced effective coupling with the electrons. Instead, the slight and diffuse enhancement of the off-diagonal terms can be mostly ascribed to multiboson scattering processes. The strong intertwining between spin and charge sectors is partly weakened at the Kondo temperature due to a progressive reduction of the effective spin-fermion coupling of local magnetic fluctuations in the low frequency regime. Our analysis, thus, clarifies the precise mechanism through which the physical information is transferred between different scattering channels of interacting electron problems and highlights the pivotal role played by such an intertwining in the physics of correlated electrons beyond the perturbative regime.

A presente pesquisa pretende apresentar os estudos acadêmicos que foram realizados com base na teoria da folkcomunicação com foco em folkmarketing, que é uma estratégia de comunicação organizacional, no período que compreende os anos de 2009 a 2018 (10 anos). O estado da arte proporciona embasamento e comprova a viabilidade de uma pesquisa. Comprova ainda que o estudo contribui para o campo de atuação da Folkcomunicação e do Folkmarketing, como teorias da comunicação. Possui relevância para a área acadêmica, pois, apesar de serem genuinamente brasileiras, seu uso ainda se mostra escasso e precisa ser propagado no campo das pesquisas, especialmente em comunicação, por sua relevância social (estudos que priorizam as minorias que se situam à margem da sociedade). Conclui-se que os estudos bibliométricos são ferramentas de inestimável valor para a área da ciência da informação, por aplicar métodos estatísticos e matemáticos a fim de analisar e construir indicadores sobre a dinâmica e evolução da informação científica e tecnológica quantificando os processos de comunicação escrita, para os periódicos e para o desenvolvimento da ciência como um todo.

Este trabalho analisa, sob a perspectiva da Folkcomunicação, como a Manifestação Cultural Aruenda da Saudade contribui para o Folkturismo e o Desenvolvimento Local no Município de Pitimbu no estado da Paraíba. A pesquisa é de natureza qualitativa com base em estudo de caso da manifestação cultural. Para obtenção dos dados foram utilizadas entrevistas com roteiro semiestruturado, observações e registros fotográficos. Os resultados da pesquisa evidenciaram que as estratégias de Folkturismo utilizadas pela Aruenda da Saudade, além de promover o turismo, têm contribuído para a consolidação do sentimento de pertencimento, identificação e valorização da cultura local, geração de renda para os artesãos e a consequente promoção do desenvolvimento local.

O presente trabalho examina a temática da responsabilidade intergeracional à luz da obra A Natureza à Margem da Lei: a Ecologia à Prova do Direito do jurista belga François Ost. Objetivar-se-á analisar os seguintes desafios teóricos: há um dever de assegurar o patrimônio ambiental para existência das futuras gerações e para qual geração futura se fala? Para responder ao problema, utilizam-se as teses sobre a natureza-projeto, que é resultado da síntese dialética dos debates antropocentristas e biocentristas existentes há séculos sobre a relação entre estas duas perspectivas teóricas. O método de pesquisa a ser utilizado será o método dedutivo. Conclui-se que será por meio do pensamento sem escalonamento ou de limitações de espaço/tempo sobre o dever e a responsabilidade intergeracional com o patrimônio comum e a humanidade, pela sua extensão ao infinito, que permitirá a conservação e sobrevivência dos seres.

The term nature deficit disorder describes the "human costs of alienation from nature" (Louv, 2019). While not meant to be a medical diagnosis, Louv argues that the condition has, "profound implications, not only for the health of future generations but for the health of the earth itself" (Louv, 2008). Children most at risk are those who live or go to school in an urban setting, as well as students diagnosed with Emotional and Behavioral Disorders (EBD). Students diagnosed with EBD are often kept indoors as their teachers and caretakers are frequently trained in the indoor use only of behavior management techniques (Riden et al., 2022). This means that during professional development training, any that pertain to behavior management techniques, procedure, or protocol are routinely taught inside of a classroom, conference room, or recently home office, using an indoor scenario (classroom, auditorium, cafeteria, etc.) as an example of when and how to use these behavior management tools. Outdoor professional development, equipping students with natural tools that can help improve not only their physical but also their mental health, as well as connecting students with nature in a way that teaches them to advocate for the health of the earth, thus becoming citizen stewards are all themes that are part of the massive, currently dysfunctional system that is outdoor education in schools. This study shows that when students are encouraged to interact with nature on their own terms on-task behaviors and motivation increase. Students also retained lesson information and asked follow-up questions after the lesson when taught outside using hands-on activities.

Abstract The aim of this investigation was to assess the effects of gamma radiation on nanocomposite films (NC films) formed by PCL (polycaprolactone) with MCM-48 nanoparticles (PCL/MCM-48) and PCL with MCM-48 NPs modified with (3-aminopropyl)triethoxysilane (APTES) (PCL/MCM-48-NH2). The nanocomposite films were obtained using the solvent casting method. After preparing the films, they were irradiated at 25 kGy in the presence of air and analyzed by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and scanning electron microscopy (SEM), transmission electronic microscopy (TEM), as well as for their mechanical properties. The exposure of NC films to gamma radiation at 25 kGy did not cause major changes in either thermal or mechanical properties such as tensile strength and modulus of elasticity. The results revealed that gamma radiation was a successful choice for the sterilization of these materials.

Nowadays, emerging radiolabeled nanosystems are revolutionizing medicine in terms of diagnostics, treatment, and theranostics. These radionuclides include polymeric nanoparticles (NPs), liposomal carriers, dendrimers, magnetic iron oxide NPs, silica NPs, carbon nanotubes, and inorganic metal-based nanoformulations. Between these nano-platforms, polymeric NPs have gained attention in the biomedical field due to their excellent properties, such as their surface to mass ratio, quantum properties, biodegradability, low toxicity, and ability to absorb and carry other molecules. In addition, NPs are capable of carrying high payloads of radionuclides which can be used for diagnostic, treatment, and theranostics depending on the radioactive material linked. The radiolabeling process of nanoparticles can be performed by direct or indirect labeling process. In both cases, the most appropriate must be selected in order to keep the targeting properties as preserved as possible. In addition, radionuclide therapy has the advantage of delivering a highly concentrated absorbed dose to the targeted tissue while sparing the surrounding healthy tissues. Said another way, radioactive polymeric NPs represent a promising prospect in the treatment and diagnostics of cardiovascular diseases such as cardiac ischemia, infectious diseases such as tuberculosis, and other type of cancer cells or tumors.

This paper analyses the folk-communication performances of project Teatro na Usina (Theater in the Plant), in the district of Bebelândia, Santa Rita city-PB, Brazil’s northeast. The aim is to check how the cultural initiative cooperates with the protagonism, empowerment and citizenship. The applicated method was a study case, during November/2016, including semi-structured interviews, with the intention of reveling the communities’ voices about the proposal and improvements caused by project. The cultural performances, after the conclusions, contribute to the local development, within social and educational aspects.

Knowledge about biological diversity is essential for the establishment of measures that lead to the protection of natural resources. Sandy beaches are areas of high diversity, with the malacofauna being an important component. Several mollusks are of great economic importance and the spatial distribution of these species on sandy beaches is linked to physical and biological factors. The aim of this study was to analyze the diversity of the malacofauna associated with Anomalocardia flexuosa distribution on a tropical sandy beach. Samples were collected bimonthly between April 2016 and February 2018 at 34 points distributed throughout a sandbar. The frequencies of occurrence of the species were calculated, and diversity indices were estimated and correlated with the densities of A. flexuosa. A total of 4,780 individuals from 11 species were obtained. The most frequent species were A. flexuosa and Neritina virginea. There were significant correlations between A. fleuxosa density and diversity, and overlap occurred between mollusks over the collection months and sites. Therefore, targeted catches for this species should also consider all other mollusks to mitigate future damage to malacofauna diversity in the region.

Hydrogels based on mixed zirconium/europium ions and benzene tricarboxylic acid were synthesized by hydrothermal reaction. A solid glass-like material is formed upon drying, showing strong reddish luminescence. The system was characterized by solid-state nuclear magnetic resonance, thermal analyses, and infrared spectroscopy. The results reveal the amorphous character of the structure and the presence of at least four types of binding modes between the metal oxide clusters and benzene tricarboxylic acid. On the other hand, thermogravimetric analysis (TGA) showed high thermal stability, with the material decomposing at temperatures higher than 500 °C. The combination of intense Eu3+ luminescence with large thermal stability makes this material a strong candidate for application as a luminescent red marker for gunshot residue (GSR). As proof of concept, we show the feasibility of this application by performing shooting tests using our compound as a GSR marker. After the shots, the residual luminescent particles could be visualized in the triggered cartridge, inner the muzzle of the firearm, and a lower amount on the hands of the shooter, using a UV lamp (λ = 254 nm). Remarkably, our results also show that the Eu3+ emission for the GSR is very similar to that observed for the original solid material. These characteristics are of huge importance since they provide a chance to use smaller amounts of the marker in the ammunition, lowering the costs of potential industrial manufacturing processes.

O presente trabalho busca apontar o uso de estratégia folkcomunicacional política usando apropriação das mídias digitais pelos grupos populares, colocando em foco os processos informais de comunicação. O objetivo é verificar como a Prefeitura da Cidade do Recife utiliza a rede social para a interação com os leitores- internautas sobre o avanço com a vacinação contra a COVID-19 da população recifense. É na apropriação de elementos da cultura folk de massas que localizamos a utilização das redes sociais como veículo da folkcomunicação política pela Prefeitura da Cidade do Recife. Folkcomunicação política; Pandemia; Mídia.

O objetivo neste trabalho foi estudar a distribuição vertical da Anomalocardia flexuosa em uma praia arenosa do nordeste brasileiro. Foram obtidas 135 amostras em três meses no ano de 2015. Para testar a hipótese entre as densidades nas profundidades de até 5 cm (densidade 5) e entre 5 e 10 cm (densidade 10) foi realizado o teste t-Student. Modelos Lineares Generalizados foram aplicados para estimar a variável resposta densidade 10 com as explicativas espaciais, temporais e de abundância. Os resultados do melhor modelo foram interpolados por métodos geoestatísticos. As densidades foram significativamente maiores na densidade 5 (450 ind.m²) do que na densidade 10 (7 ind.m²). Entre os modelos avaliados, o com Binomial Negativa inflada de zeros foi o selecionado, sendo as predições interpoladas verossímeis com o observado, e as variáveis utilizadas foram: densidade 5, latitude, longitude (transformada) e mês (contínuo). A ocupação de A. flexuosa em camadas mais profundas do substrato pode decorrer de um enterramento acidental e ser atribuída a forçantes físicas, e não ser uma causa comportamental. Dessa maneira, o manejo sobre essa espécie deve considerar meios de captura que não penetrem o substrato além da camada preferencial, para assim não impactar outros organismos não alvo da pesca.

A extração de lagostas é considerada a atividade pesqueira mais atrativa economicamente na região Nordeste do Brasil. Neste trabalho, foram avaliadas as variações das capturas das lagostas Panulirus meripurpuratus (lagosta vermelha), Panulirus laevicauda (lagosta verde) e Scyllarides brasiliensis (lagosta sapata) no estado de Pernambuco, nos anos de 1999 a 2006, com intuito de verificar tendências nas produções mensais e a relação entre as capturas realizadas nos meses de defeso e na temporada de pesca. As capturas por temporada foram estudadas a partir de modelos exponenciais e análises de correlações. Modelos exponenciais foram significativos com coeficientes de determinação acima de 0,65 para lagosta vermelha em todos os anos e para a lagosta verde a partir de 2002, e descreveram os decaimentos das capturas do início até o final da temporada. A biomassa da lagosta verde mostrou um decaimento mais acentuado do que a da vermelha, possivelmente porque o coeficiente de capturabilidade seria maior. Já para a lagosta sapata, os modelos tiveram valores dos coeficientes de determinação sempre inferiores a 0,40. A correlação entre a captura legal e ilegal foi significativa apenas para a lagosta verde e apresentou tendência positiva. A magnitude inicial das capturas para a lagosta vermelha com valores abaixo de 25 toneladas no início da temporada de pesca pode ser um indício alarmante, enquanto para lagosta verde, esse valor pode ser de 10 toneladas. Estudos com modelos de excedente de produção são necessários para melhor avaliar os estoques e verificar a hipótese de que a lagosta verde teria um coeficiente de capturabilidade maior que o da lagosta vermelha.

O objetivo neste trabalho foi estudar a diversidade da ictiofauna capturada com a rede de emalhar mais utilizada no estado de Pernambuco. No total foram realizadas 14 coletas no Canal de Santa Cruz (CSC) entre os meses de julho de 2013 e junho de 2014. As amostras foram obtidas com rede de emalhar de malha de 30 mm. Os peixes capturados foram retirados e separados na posição margem e centro, e na posição vertical da rede (superior, meio e inferior). Quanto à frequência de ocorrência, as espécies foram classificadas como comuns, acessórias ou ocasionais. Foram realizadas análises de diversidade alfa e beta. No total foram capturadas 19 espécies, sendo Opisthonema oglinum e Anchovia clupeoides as únicas constantes. As diversidades alfa estimadas não apresentaram diferenças significativas nos estratos temporais e espaciais. Na diversidade beta dois grupos se distinguiram, sendo que no maior ocorreu geralmente grandes abundâncias de O. oglinum. A rede avaliada foi eficiente para a espécie alvo O. oglinum e as capturas de outras espécies corresponderam a menos de 13% da icitiofauna já encontrada no CSC. Portanto, medidas de gestão que visem restringir o uso do petrecho para a proteção da diversidade, considerando a sazonalidade e espacialidade no canal, não são recomendadas.

ABSTRACT: A type of dredge was introduced as fishing gear along the extractive bank of Mangue Seco - PE from which the largest annual catch of Anomalocardia flexuosa in the world is extracted. This study was carried out with the objective of estimating the selectivity of the new fishing gear and quantitatively evaluating the length classes most compromised by the catches, especially considering 20 mm as the reference value. Specimens larger than this size are most likely to be mature. For the selectivity estimation, the methodology using codends (16 or 20 mm) and small meshed cover (2 mm) was used. To estimate the selectivity parameters, a logistic regression and the Bayesian approach were used. The transition between the state in which the specimen is invulnerable to the fishing gear and vulnerable occurs between 10 and 18 mm, using a 16 mm mesh, and using a 20 mm mesh, this transition is between 14 and 20 mm. Dredgers with 16 mm and 20 mm mesh compromise a large proportion of specimens smaller than 20 mm. If the intention is to protect this part of the population, measures such as total restriction of the 16 mm mesh and use of the 20 mm mesh should be necessary only in the months of less catching incidences, or increasing the mesh to 25 mm.

In this work, we report the synthesis of a new 1,3-thiazolium-5-thiolate derivative of a mesoionic compound (MIH 2.4Bl) and the characterization of its selective cytotoxicity on a panel of breast cancer cells lines. The cytotoxic effect of MIH 2.4Bl on breast cancer cell lines was determined by XTT and crystal violet assays, flow cytometry analysis, electron microscopy characterization, and terminal deoxynucleotidyl transferase (TdT) deoxyuridine triphosphate (dUTP) nick end labeling (TUNEL) apoptosis assays. As determined using XTT cell growth and survival assays, MIH 2.4Bl exhibited growth inhibition activity on most breast cancer cell lines tested, compared with normal human mammary epithelial cells. Three breast cancer cell lines (MCF-7, T-47D, and ZR-75-1) showed a more potent sensitivity index to growth inhibition by MIH 2.4Bl than the other breast cancer cell lines. Interestingly, these 3 cell lines were derived from tumors of Luminal A origin and have ER (estrogen receptor), PR (progesterone receptor), and HER2 (human epidermal growth factor receptor 2) positive expression. Additional analysis of cytotoxicity mediated by MIH 2.4Bl was performed using the MCF-7 cell line. MCF-7 cells displayed both time- and dose-dependent decreases in cell growth and survival, with a maximum cytotoxic effect observed at 72 and 96 hours. The MCF-7 cells were also characterized for cell cycle changes upon treatment with MIH 2.4Bl. Using flow cytometry analysis of cell cycle distribution, a treatment-dependent effect was observed; treatment of cells with MIH 2.4Bl increased the G2/M population to 34.2% compared with 0.1% in untreated (control) cells. Ultrastructural analysis of MFC-7 cells treated with MIH 2.4Bl at 2 different concentrations (37.5 and 75 μM) was performed by transmission electron microscopy. Cells treated with 37.5 μM MIH 2.4Bl showed morphologic changes beginning at 6 hours after treatment, while cells treated with 75 μM showed changes beginning at 3 hours after treatment. These changes were characterized by an alteration of nuclear morphology and mitochondrial degeneration consistent with apoptotic cell death. Results of a TUNEL assay performed on cells treated for 96 hours with MIH 2.4Bl supported the observation of apoptosis. Together, these results suggest that MIH 2.4Bl is a promising candidate for treating breast cancer and support further in vitro and in vivo investigation.

Foi objetivo da pesquisa identificar a frequência genotípica da ACTN3 e associa-la ao índice técnico (IT) e ao status de elite em 98 atletas juvenis de natação (16,80 ± 0,63 anos) especialistas em curtas distâncias (≤ 200m). Um grupo controle (GC) com 101 escolares não-atletas (16,52 ± 0,94 anos) foi incluído nas comparações. Os grupos foram analisados sem divisão por sexo. Os atletas foram divididos pelas experiências competitivas em elite (internacionais, n = 15) e sub-elite (nacionais, n = 83). Não verificou-se diferenças significativas (X2) na frequência genotípica entre atletas sub-elite e GC. Os atletas de elite apresentaram supremacia do genótipo RX (60,0%), baixa frequência do genótipo RR (13,3%), supremacia do alelo X (54,2%) e da adição RX+XX (86,7%). O ajuste das frequências genotípicas pelo quartil superior (QS) do IT revelou que os atletas com genótipos RR+RX apresentaram maior pontuação média (820,6 ± 40,0) quando comparados aos atletas XX (806,7 ± 34,8). Atletas de elite do grupo QS (RR+RX) apresentaram valores médios do IT ainda mais expressivos (853,9 ± 31,3). Os genótipos da ACTN3 demonstraram boa associação aos fenótipos da força/potência apenas entre os atletas identificados nos mais altos níveis de desempenho.

Este trabalho teve como objetivo analisar o papel desempenhado por ativistas-folk na comunidade rurbana Padre Hildon Bandeira, situada em João Pessoa-PB, sob a perspectiva do Desenvolvimento Local e da Teoria da Folkcomunicação. Do estudo, evidenciamos em que medida os atores sociais contribuem para a nutrição de redes cívicas e de comunicação, criando oportunidades, democratizando socialmente a comunidade e estabelecendo relações de solidariedade e confiança, bem como angariando benefícios sociais junto aos poderes públicos.

A praia de Mangue Seco, no estado de Pernambuco, é um local com grande quantidade de ecossistemas e se destaca principalmente pela captura da espécie Anomalocardia flexuosa. Neste trabalho foi proposto um zoneamento dessa praia de acordo com as características mais expressivas e também considerando as densidades da Anomalocardia flexuosa. No delineamento da região foram considerados primeiramente os efeitos das águas circundantes e a proximidade da linha de praia; assim, três principais estratos de localização foram avaliados (borda, interior costa e interior mar), além de estratos secundários com divisões latitudinais e longitudinais. No total foram obtidas 176 amostras em campanhas realizadas no ano de 2015. As médias das densidades foram maiores no setor interior costa em todas as campanhas. As zonas localizadas próximas a estuários pareceram mais propícias ao estabelecimento da espécie quando comparadas a locais com maior interferência marinha. Foi possível diferenciar, principalmente, quatro estratos de localização de acordo com as características morfodinâmicas e as densidades da Anomalocardia flexuosa. O primeiro estrato e o mais abundante seria o interior costa, o segundo o interior mar e o estrato borda seria dividido em dois substratos, um mais afastado da linha de praia e outro mais próximo às saídas de foz.

A relação estreita entre mídia, turismo e cultura popular expandiu o olhar dos discípulos de Luiz Beltrão, que a partir da Folkcomunicação, teoria genuinamente brasileira, observaram a apropriação dos bens culturais como atrações turística através de meios de informação e da comunicação. Elementos da produção local como manifestações culturais, religiosas e gastronômicas, por exemplo, passam a se tornar produtos vendáveis que impactam principalmente na economia da região. Dessa forma, esta pesquisa tem por base apontar a Queijada de Dona Marieta como elemento folkturistico na cidade de São Cristóvão, como estratégia para o desenvolvimento local. A contribuição deste debate consiste em fortalecer o reconhecimento da teoria beltraniana, bem como expandir os olhares dos discípulos de Luiz Beltrão.

BACKGROUND: Phenotypic heterogeneity in early language, intellectual, motor, and adaptive functioning (LIMA) features are amongst the most striking features that distinguish different types of autistic individuals. Yet the current diagnostic criteria uses a single label of autism and implicitly emphasizes what individuals have in common as core social-communicative and restricted repetitive behavior difficulties. Subtype labels based on the non-core LIMA features may help to more meaningfully distinguish types of autisms with differing developmental paths and differential underlying biology. METHODS: Unsupervised data-driven subtypes were identified using stability-based relative clustering validation on publicly available Mullen Scales of Early Learning (MSEL) and Vineland Adaptive Behavior Scales (VABS) data (n = 615; age = 24-68 months) from the National Institute of Mental Health Data Archive (NDA). Differential developmental trajectories between subtypes were tested on longitudinal data from NDA and from an independent in-house dataset from UCSD. A subset of the UCSD dataset was also tested for subtype differences in functional and structural neuroimaging phenotypes and relationships with blood gene expression. The current subtyping model was also compared to early language outcome subtypes derived from past work. RESULTS: Two autism subtypes can be identified based on early phenotypic LIMA features. These data-driven subtypes are robust in the population and can be identified in independent data with 98% accuracy. The subtypes can be described as Type I versus Type II autisms differentiated by relatively high versus low scores on LIMA features. These two types of autisms are also distinguished by different developmental trajectories over the first decade of life. Finally, these two types of autisms reveal striking differences in functional and structural neuroimaging phenotypes and their relationships with gene expression and may highlight unique biological mechanisms. LIMITATIONS: Sample sizes for the neuroimaging and gene expression dataset are relatively small and require further independent replication. The current work is also limited to subtyping based on MSEL and VABS phenotypic measures. CONCLUSIONS: This work emphasizes the potential importance of stratifying autism by a Type I versus Type II distinction focused on LIMA features and which may be of high prognostic and biological significance.

Abstract: Terrestrial groundwater travels through subterranean estuaries before reaching the sea. Groundwater‐derived nutrients drive coastal water quality, primary production, and eutrophication. We determined how dissolved inorganic nitrogen (DIN), dissolved inorganic phosphorus (DIP), and dissolved organic nitrogen (DON) are transformed within subterranean estuaries and estimated submarine groundwater discharge (SGD) nutrient loads compiling > 10,000 groundwater samples from 216 sites worldwide. Nutrients exhibited complex, nonconservative behavior in subterranean estuaries. Fresh groundwater DIN and DIP are usually produced, and DON is consumed during transport. Median total SGD (saline and fresh) fluxes globally were 5.4, 2.6, and 0.18 Tmol yr−1 for DIN, DON, and DIP, respectively. Despite large natural variability, total SGD fluxes likely exceed global riverine nutrient export. Fresh SGD is a small source of new nutrients, but saline SGD is an important source of mostly recycled nutrients. Nutrients exported via SGD via subterranean estuaries are critical to coastal biogeochemistry and a significant nutrient source to the oceans.

Folkmarketing becomes extremely current when it comes to market-oriented marketing and horizontal marketing because it aims to communicate and satisfy consumers' needs and desires through the use of appropriations of popular culture. The article proposes to present the results of the analysis of the brand New Passion of Christ as a folkmarketing strategy for the local development of Fazenda Nova, Brejo district of Madre de Deus, Pernambuco. For this, bibliographical, documentary and field researches are used, qualitative method in semistructured questionnaire and studies based on authors such as Luiz Beltrão, Severino Lucena, Daniel Galindo and Paulo de Jesus. The results present the strategies of Folkmarketing as a great differential in marketing communication in front of the promotion of the local culture, potentializing the economy and contributing to the Local Development process.

This article examines, through Folkcommunication, the historical and social process of the coronelist regime during the First Republic (1889-1930) in Brazil, and its connotations in present time. The aim was to analyze folkcommunicational and neocoronelist discursive manifestations practiced by Cássio Cunha Lima (from the Brazilian Social Democratic Party, PSDB), during the elections for the governor of the State of Paraíba in 2014, and published at the internet portal of the coalition A Vontade do Povo (People’s Will, in free translation). It is concluded that Coronelism is still a current practice in our country, mastering the power no more by violence, but by the relation between personality and charisma of the politician and the population.

Anarriê, Alavantu! During the month of June, the Northeastern people celebrate the popular festivities dedicated to the saints of June, to the sound of much forró. The gang became the typical dance of the party, where several couples shout, intertwine between tapes and hands, like the Junina Tradition, from Morro da Conceição, on the outskirts of Recife, Pernambuco. However, the gang members of this group use dance not only as fun, but as a space of struggle, resistance, and prejudice. Within this context, the work analyzes the folkcomunicacional performances in the JuninaTradição, that are constructors of the local development, in the social and political scope, according to the obtained results. It is a study from the perspective of Folkcommunication, in which documental analysis and semistructured interview were used.