1. Salivary gland hyalinizing clear-cell carcinoma with cutaneous metastasis: A rare and deceptive tumor.
- Author
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Shaar RA, Zia S, Alhamar M, Romano T, Shaw B, Keller C, and Friedman BJ
- Subjects
- Adenocarcinoma, Clear Cell genetics, Adult, Female, Head and Neck Neoplasms genetics, Humans, Oncogene Proteins, Fusion, Pregnancy, Pregnancy Complications, Neoplastic genetics, Pregnancy Complications, Neoplastic pathology, Salivary Gland Neoplasms genetics, Salivary Glands, Minor pathology, Scalp pathology, Skin Neoplasms genetics, Adenocarcinoma, Clear Cell secondary, Head and Neck Neoplasms secondary, Salivary Gland Neoplasms pathology, Skin Neoplasms secondary
- Abstract
Clear-cell carcinoma (CCC) is an uncommon malignant tumor of minor salivary glands. It characteristically has a low-grade morphology and a favorable outcome by most reports. An EWSR1-ATF1 fusion can be detected in the majority of cases. We present a rare case of CCC, which had an aggressive course with the development of cutaneous metastases. Practicing dermatopathologists should be aware of this tumor given its low-grade appearance and histopathologic resemblance to other primary cutaneous adnexal and metastatic neoplasms., (© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Published
- 2021
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