Search

Your search keyword '"Sharpe, Claire"' showing total 255 results
Start Over Author "Sharpe, Claire"
255 results on '"Sharpe, Claire"'

2. Achieving Benchmarks for National Quality Indicators Reduces Recurrence and Progression in Non–muscle-invasive Bladder Cancer

Author

Mariappan, Paramananthan, Johnston, Allan, Trail, Matthew, Hamid, Sami, Hollins, Graham, Dreyer, Barend A., Ramsey, Sara, Padovani, Luisa, Garau, Roberta, Enriquez, Julia Guerrero, Boden, Alasdair, Maresca, Gianluca, Simpson, Helen, Hasan, Rami, Sharpe, Claire, Thomas, Benjamin G., Chaudhry, Altaf H., Khan, Rehan S., Bhatt, Jaimin R., Ahmad, Imran, Nandwani, Ghulam M., Dimitropoulos, Konstantinos, Makaroff, Lydia, Shaw, Johnstone, Graham, Catriona, and Hendry, David

Published
2024
Full Text
View/download PDF

4. dhb Trail Women's Waterproof Jacket Review

Author

Sharpe, Claire

Subjects
Sports and fitness
Abstract

Byline: Claire Sharpe The dhb Trail Waterproof Jacket lacks some more premium features, but delivers in both form and function A rainy day ride is never a bad idea, especially [...]

Published
2023

5. Albion Women's All Road Pertex Shield Rain Jacket

Author

Sharpe, Claire

Subjects
Sports and fitness
Abstract

Byline: Claire Sharpe Performance wear done right; Albion has pulled it out the bag with this one. A series of soggy and grey afternoons charging across Bristol was the perfect [...]

Published
2023

8. Sickle Cell Trait and Kidney Disease in People of African Ancestry With HIV

Author

Booth, John, Waters, Anele, Hand, James, Clarke, Chris, Murphy, Sarah, Murphy, Maurice, Campbell, Marion, Clarke, Amanda, Richardson, Celia, Knott, Alyson, Weir, Gemma, Cleig, Rebecca, Soviarova, Helena, Barbour, Lisa, Adams, Tanya, Kennard, Vicky, Trevitt, Vittorio, Jones, Rachael, Levy, Jeremy, Schoolmeester, Alexandra, Duro, Serah, Hilton, Rachel, Fox, Julie, Rabuya, May, Hamzah, Lisa, Jordan, Deborah, Solano, Teresa, Uzu, Hiromi, Williams, Karen, Lwanga, Julianne, Reid-Amoruso, Linda Ekaette, Gamlen, Hannah, Stocker, Robert J., Ryan, Fiona, Mahiouz, Karina, Cheetham, Tess, Williams, Claire, Nori, Achyuta, Thomas, Caroline, Venkateshwaran, Sivaraj, Doctor, Jessica, Berlanga, Andrea, Post, Frank, Santana-Suarez, Beatriz, McQueen, Leigh, Bhagwandin, Priya, Campbell, Lucy, Barbini, Bee, Wandolo, Emily, Appleby, Tim, Driver, Lois, Parr, Sophy, Deng, Hongbo, Barber, Julie, Crowe, Andrew, Taylor, Chris, Poulton, Mary, Boateng, Vida, Klein, Marie-Pierre, O’Brien, Caitlin, Ohene-Adomako, Samuel, Buckingham, Christian, Trotman, Daniel, Quinn, Killian, Flanagan, Kate, Sullivan, Verity, Middleditch, Holly, Samuel, Itty, Hamlyn, Elizabeth, McDonald, Candice, Canoso, Ana, Agbasi, Emeka, Liskova, Maria, Barber, Sarah, Samarawickrama, Amanda, Ottaway, Zoe, Norcross, Claire, Oliveira, Amelia, Bramham, Kate, Minton, Jane, Lamont, Gary, Cross, Ruby, Saiyad, Gaushiya, Ahmed, Shadia, Ashworth, Rebecca, Window, Nicola, Murira, J., Phyu, Khine, Ustianowski, Andrew, Lindergard, Gabriella, Shaw, Jonathan, Holland, Sarah, Fox, Claire, Flaherty, Jan, Bevan, Margaret-Anne, George, Valerie, Chadwick, David, Branch, Marie, Lambert, Pauline, Craggs, Adele, Pett, Sarah, Lukha, Hinal, Vora, Nina, Fiorino, Marzia, Nunez, Maria Muller, Sally, Deirdre, Burns, James E., Pool, Erica, Matthews, Rebecca, Price, David Ashley, Stothard, Tara, Patel, Bijal, McVittie, Ian, Kennedy, Ciara, Shwab, Uli, Payne, Brendan, Duncan, Sarah, Dixon, Jill, Schmid, Mathias, Evans, Adam, Duncan, Christopher, Hunter, Ewan, Taha, Yusri, Astill, Natasha, Winkler, Cheryl, Binns-Roemer, Elizabeth, David, Victor, Ainsworth, Jonathan, Vincent, Rachel, Kegg, Stephen, Saad, Chloe, Skinner, Sarah, Azzoug, Hocine, Russell, Judith, Moussaoui, Tarik, Mabonga, Emily, Ward, Donna, Francoise, J., Larbi, W., Mitchell, Sue, Manning, A., Russell, V., Burns, Fiona, Harber, Mark, Ngwu, Nnenna, Edwards, Jonathan, Hemat, Nargis, Fernandez, Tom, Ferro, Filippo, Ferreira, Jorge, Nightingale, Alice, Oakes-Monger, Tasha, Matila, Darwin, Nogueira, Pedro, Mutagwanya, Victoria, Cosgrove, Catherine, Isitt, Catherine Emily, Webb, Helen, Popoola, Joyce, Korley, Kate, Mencias, Mark, Ribeiro, Patricia, Ramkhelawn, Rajeshwar, Lara, Sandra Oliva, Sajijad, Sara, Winston, Alan, Shaw, Amber, Petersen, Claire, Ring, Kyle, Rosenvinge, Melanie, Moyo, Thembi, Odong, Faith, Gantert, Katherine, Ibe, Tina, Onyango, Denis, Sabin, Caroline, Hill, Teresa, Hung, Rachel K.Y., Booth, John W., Price, David A., Sharpe, Claire C., Sabin, Caroline A., Winkler, Cheryl A., and Post, Frank A.

Published
2022
Full Text
View/download PDF

13. Twelve tips to aid interpretation of post-assessment psychometric reports.

Author

Tavakol, Mohsen, O'Brien, David G., Sharpe, Claire C., and Stewart, Claire

Subjects
STATISTICS, STATISTICAL reliability, RESEARCH evaluation, RATING of students, EDUCATIONAL tests & measurements, PSYCHOMETRICS, DATA analysis, EDUCATIONAL outcomes
Abstract

Post-assessments psychometric reports are a vital component of the assessment cycle to ensure that assessments are reliable, valid and fair to make appropriate pass-fail decisions. Students' scores can be summarised by examination of frequency distributions, central tendency measures and dispersion measures. Item discrimination indicies to assess the quality of items, and distractors that differentiate between students achieving or not achieving the learning outcomes are key. Estimating individual item reliability and item validity indices can maximise test-score reliability and validity. Test accuracy can be evaluated by assessing test reliability, consistency and validity and standard error of measurement can be used to measure the variation. Standard setting, even by experts, may be unreliable and reality checks such as the Hofstee method, P values and correlation analysis can improve validity. The Rasch model of student ability and item difficulty assists in modifying assessment questions, pinpointing areas for additional instruction. We propose 12 tips to support test developers in interpreting structured psychometric reports, including analysis and refinement of flawed items and ensuring fair assessments with accurate and defensible marks. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

14. Correction to: COVID-19-related acute kidney injury; incidence, risk factors and outcomes in a large UK cohort

Author

Jewell, Paul D., Bramham, Kate, Galloway, James, Post, Frank, Norton, Sam, Teo, James, Fisher, Richard, Saha, Rohit, Hutchings, Sam, Hopkins, Phil, Smith, Priscilla, Joslin, Jennifer, Jayawardene, Satish, Mackie, Sarah, Mudhaffer, Ali, Holloway, Amelia, Kibble, Henry, Akter, Mosammat, Zuckerman, Benjamin, Palmer, Kieran, Murphy, Ciara, Iatropoulou, Domniki, Sharpe, Claire C., and Lioudaki, Eirini

Published
2021
Full Text
View/download PDF

15. COVID-19-related acute kidney injury; incidence, risk factors and outcomes in a large UK cohort

Author

Jewell, Paul D., Bramham, Kate, Galloway, James, Post, Frank, Norton, Sam, Teo, James, Fisher, Richard, Saha, Rohit, Hutchings, Sam, Hopkins, Phil, Smith, Priscilla, Joslin, Jennifer, Jayawardene, Satish, Mackie, Sarah, Mudhaffer, Ali, Holloway, Amelia, Kibble, Henry, Akter, Mosammat, Zuckerman, Benjamin, Palmer, Kieran, Murphy, Ciara, Iatropoulou, Domniki, Sharpe, Claire C., and Lioudaki, Eirini

Published
2021
Full Text
View/download PDF

30. Severity of COVID-19 after Vaccination among Hemodialysis Patients

Author

Ashby, Damien R., primary, Caplin, Ben, additional, Corbett, Richard W., additional, Asgari, Elham, additional, Kumar, Nicola, additional, Sarnowski, Alexander, additional, Hull, Richard, additional, Makanjuola, David, additional, Cole, Nicholas, additional, Chen, Jian, additional, Nyberg, Sofia, additional, McCafferty, Kieran, additional, Zaman, Faryal, additional, Cairns, Hugh, additional, Sharpe, Claire, additional, Bramham, Kate, additional, Motallebzadeh, Reza, additional, Anwari, Kashif Jamil, additional, Salama, Alan D., additional, and Banerjee, Debasish, additional

Published
2022
Full Text
View/download PDF

31. Sickle Cell Trait and Kidney Disease in People of African Ancestry With HIV

Author

Hung, Rachel K.Y., primary, Binns-Roemer, Elizabeth, additional, Booth, John W., additional, Hilton, Rachel, additional, Fox, Julie, additional, Burns, Fiona, additional, Harber, Mark, additional, Ustianowski, Andrew, additional, Hamzah, Lisa, additional, Burns, James E., additional, Clarke, Amanda, additional, Price, David A., additional, Kegg, Stephen, additional, Onyango, Denis, additional, Santana-Suarez, Beatriz, additional, Campbell, Lucy, additional, Bramham, Kate, additional, Sharpe, Claire C., additional, Sabin, Caroline A., additional, Winkler, Cheryl A., additional, Post, Frank A., additional, Booth, John, additional, Waters, Anele, additional, Hand, James, additional, Clarke, Chris, additional, Murphy, Sarah, additional, Murphy, Maurice, additional, Campbell, Marion, additional, Richardson, Celia, additional, Knott, Alyson, additional, Weir, Gemma, additional, Cleig, Rebecca, additional, Soviarova, Helena, additional, Barbour, Lisa, additional, Adams, Tanya, additional, Kennard, Vicky, additional, Trevitt, Vittorio, additional, Jones, Rachael, additional, Levy, Jeremy, additional, Schoolmeester, Alexandra, additional, Duro, Serah, additional, Rabuya, May, additional, Jordan, Deborah, additional, Solano, Teresa, additional, Uzu, Hiromi, additional, Williams, Karen, additional, Lwanga, Julianne, additional, Reid-Amoruso, Linda Ekaette, additional, Gamlen, Hannah, additional, Stocker, Robert J., additional, Ryan, Fiona, additional, Mahiouz, Karina, additional, Cheetham, Tess, additional, Williams, Claire, additional, Nori, Achyuta, additional, Thomas, Caroline, additional, Venkateshwaran, Sivaraj, additional, Doctor, Jessica, additional, Berlanga, Andrea, additional, Post, Frank, additional, McQueen, Leigh, additional, Bhagwandin, Priya, additional, Barbini, Bee, additional, Wandolo, Emily, additional, Appleby, Tim, additional, Driver, Lois, additional, Parr, Sophy, additional, Deng, Hongbo, additional, Barber, Julie, additional, Crowe, Andrew, additional, Taylor, Chris, additional, Poulton, Mary, additional, Boateng, Vida, additional, Klein, Marie-Pierre, additional, O’Brien, Caitlin, additional, Ohene-Adomako, Samuel, additional, Buckingham, Christian, additional, Trotman, Daniel, additional, Quinn, Killian, additional, Flanagan, Kate, additional, Sullivan, Verity, additional, Middleditch, Holly, additional, Samuel, Itty, additional, Hamlyn, Elizabeth, additional, McDonald, Candice, additional, Canoso, Ana, additional, Agbasi, Emeka, additional, Liskova, Maria, additional, Barber, Sarah, additional, Samarawickrama, Amanda, additional, Ottaway, Zoe, additional, Norcross, Claire, additional, Oliveira, Amelia, additional, Minton, Jane, additional, Lamont, Gary, additional, Cross, Ruby, additional, Saiyad, Gaushiya, additional, Ahmed, Shadia, additional, Ashworth, Rebecca, additional, Window, Nicola, additional, Murira, J., additional, Phyu, Khine, additional, Lindergard, Gabriella, additional, Shaw, Jonathan, additional, Holland, Sarah, additional, Fox, Claire, additional, Flaherty, Jan, additional, Bevan, Margaret-Anne, additional, George, Valerie, additional, Chadwick, David, additional, Branch, Marie, additional, Lambert, Pauline, additional, Craggs, Adele, additional, Pett, Sarah, additional, Lukha, Hinal, additional, Vora, Nina, additional, Fiorino, Marzia, additional, Nunez, Maria Muller, additional, Sally, Deirdre, additional, Pool, Erica, additional, Matthews, Rebecca, additional, Price, David Ashley, additional, Stothard, Tara, additional, Patel, Bijal, additional, McVittie, Ian, additional, Kennedy, Ciara, additional, Shwab, Uli, additional, Payne, Brendan, additional, Duncan, Sarah, additional, Dixon, Jill, additional, Schmid, Mathias, additional, Evans, Adam, additional, Duncan, Christopher, additional, Hunter, Ewan, additional, Taha, Yusri, additional, Astill, Natasha, additional, Winkler, Cheryl, additional, David, Victor, additional, Ainsworth, Jonathan, additional, Vincent, Rachel, additional, Saad, Chloe, additional, Skinner, Sarah, additional, Azzoug, Hocine, additional, Russell, Judith, additional, Moussaoui, Tarik, additional, Mabonga, Emily, additional, Ward, Donna, additional, Francoise, J., additional, Larbi, W., additional, Mitchell, Sue, additional, Manning, A., additional, Russell, V., additional, Ngwu, Nnenna, additional, Edwards, Jonathan, additional, Hemat, Nargis, additional, Fernandez, Tom, additional, Ferro, Filippo, additional, Ferreira, Jorge, additional, Nightingale, Alice, additional, Oakes-Monger, Tasha, additional, Matila, Darwin, additional, Nogueira, Pedro, additional, Mutagwanya, Victoria, additional, Cosgrove, Catherine, additional, Isitt, Catherine Emily, additional, Webb, Helen, additional, Popoola, Joyce, additional, Korley, Kate, additional, Mencias, Mark, additional, Ribeiro, Patricia, additional, Ramkhelawn, Rajeshwar, additional, Lara, Sandra Oliva, additional, Sajijad, Sara, additional, Winston, Alan, additional, Shaw, Amber, additional, Petersen, Claire, additional, Ring, Kyle, additional, Rosenvinge, Melanie, additional, Moyo, Thembi, additional, Odong, Faith, additional, Gantert, Katherine, additional, Ibe, Tina, additional, Sabin, Caroline, additional, and Hill, Teresa, additional

Published
2022
Full Text
View/download PDF

32. Additional file 1 of Stimulated phosphorylation of ERK in mouse kidney mesangial cells is dependent upon expression of Cav3.1

Author

Pandi, Sudha Priya Soundara, Shattock, Michael J., Hendry, Bruce M., and Sharpe, Claire C.

Abstract

Additional file 1: Supplementary material. Bacterial transformation, plasmidpurification and validation, selection and validationof single-cell clones. SupplementaryFigure S1. Confirmation of TTCC isoform in Mouse mesangial cells andmodulation of its proliferation by TTCC blockers. (a, b, c) RT-PCR for the Ttype calcium isoforms were detected in mouse mesangial cells (MES13). The bandin each lane in the agarose gel represent the PCR product of the T type calciumisoforms Cacna1G, Cacna1H and Cacna1I (PCR product size: CaV3.1-376; CaV3.2-594;CaV3.3-528). mRNA of the CaV3.3 in 72 h treatment with PDGF and TGFβ1 aloneshown faint band. Supplementary FigureS2. Validation of CRISPR-cas9- gRNA for cacna1G and Cacna1H. plenti-CRISPR-cas9-cacna1G a) andplenti-CRISPR-cas9-cacna1H b) vector map expressing gRNA mapping to exon 4 of36 exons containing cacna1G gene and on exon 6 of 35 exons containing cacna1Hgene under the control of U6 promoter, with selection markers ampicillin forprokaryotic and puromycin for mammalian cell selection. a) and b) plasmids wereconfirmed by restriction digestion by MluI restriction enzyme and by sangersequencing using primer designed for U6 promoter. (gRNA sequences:Cacnca1G-TCCGTGTGCTGCGACCGCTC, Cacna1H- ACCTGACGAA GGCGCTGTCC). Gel: Panel A:Lane 1-10KB ladder, Lane 2 –circular plasmid, Lane 3-No restriction enzymecontrol, Lane 4- plasmid digested by Mlu. Panel B: Lane 1 –circular plasmid,Lane 2-No restriction enzyme control, Lane 3- plasmid digested by Mlu, Lane4-10KB ladder. Yellow highlight - gRNA sequence. Supplementary Figure S3. Confirmation of CaV3.1 and CaV3.2knockout at the genomic level. a) PCR amplificationfor CaV3.1 (left panel) and CaV3.2 (right panel) genes inthe six clones each from cacna1G and cacna1h by using primers spanning gRNA region. Cacna1G clone 2 and Cacna1H clone 3harbouring indel mutation shows PCR product shift compare to control. b)Sequencing analysis of cacna1G and cacna1H knockout in the clone 2 of cacna1G,clone 3 of cacna1H. Sequencing resultsshow deletion of the gRNA sequence with the frameshift mutation compare to wildtype (WT) control, confirming the knockouts. Right panel-sequencing forcacna1G; left panel- sequencing for cacna1H. Yellow highlight represents the sequencebefore gRNA in the gene and grey highlight represent the gRNA sequence. Supplementary Figure S4. Confirmation of cacna1G and cacna1H knockout at thepost-translational level. Western blot for CaV3.1(a) protein expression in the single-cell clones of CaV3.1 knockoutshow absence of bands in all six CaV3.1 KO clones compared to wildtype cells and the positive control mouse brain. (b) single-cell clone of CaV3.2KO shows the absence of bands in 5 clones compared to wild type and positivecontrol HEK cell overexpressing CaV3.2. Loading control- actin. Supplementary FigureS5: Figure shows the full-length image ofWestern blot for Figure 2a described in the main text. Supplementary Figure S6: Figure shows the full-length image ofWestern blot for Figure 3a described in the main text. Supplementary Figure S7: Figure shows the full-length image ofWestern blot for Figure 4a and 4c described in the main text. Supplementary Table S1: Primers list, 1.28 MB, PDF.

Published
2022
Full Text
View/download PDF

34. Point of care testing using rapid automated antigen testing for SARS-COV-2 in care homes – an exploratory safety, usability and diagnostic agreement evaluation

Author

Micocci, Massimo, primary, Buckle, Peter, additional, Hayward, Gail, additional, Allen, A Joy, additional, Davies, Kerrie, additional, Kierkegaard, Patrick, additional, Spilsbury, Karen, additional, Thompson, Carl, additional, Astle, Anita, additional, Heath, Ros, additional, Sharpe, Claire, additional, Akrill, Cyd, additional, Lasserson, Dan, additional, Perera, Rafael, additional, Body, Richard, additional, and Gordon, Adam L, additional

Published
2021
Full Text
View/download PDF

35. A Phase II, Randomized, Multicenter, Open-Label Study Evaluating the Effect of Crizanlizumab and Standard of Care (SoC) Versus Standard of Care Alone on Renal Function in Patients with Chronic Kidney Disease Due to Sickle Cell Nephropathy (STEADFAST)

Author

Saraf, Santosh L., primary, Ataga, Kenneth I., additional, Derebail, Vimal K., additional, Sharpe, Claire C., additional, Inati, Adlette, additional, Lebensburger, Jeffrey D., additional, DeBonnett, Laurie, additional, Zhang, Yifan, additional, and Bartolucci, Pablo, additional

Published
2021
Full Text
View/download PDF

36. Contributors

Author

Adler, Sharon, Agarwal, Anupam, Agarwal, Rajiv, Aiyagari, Venkatesh, Alberton, Valeria, Anand, Shuchi, Arogundade, Fatiu, Arroyo, Vicente, Ash, Stephen R., Auguste, Bourne, Bailey, Matthew A., Bakris, George L., Bansal, Anip, Bargman, Joanne M., Barlow, Adam D., Barratt, Jonathan, Barsoum, Rashad S., Beaubien-Souligny, William, Beck, Laurence H., Jr, Bello, Aminu K., Benigni, Ariela, Berl, Tomas, Bircher, Gemma, Bockenhauer, Detlef, Boor, Peter, Bouchard, Josée, Bramham, Kate, Bridoux, Frank, Brown, Edwina, Brown, Mark, Burdmann, Emmanuel A., Bushinsky, David A., Cara-Fuentes, Gabriel, Cervelli, Matthew, Chadban, Steven James, Chan, Christopher, Chan, Christopher T., Chan, Melanie M.Y., Chapman, Jeremy R., Charlton, Karen, Chen, Wei, Cherney, David Z., Chua, Annabelle, Cohen-Stein, Debbie, Connolly, John O., Cook, Terence, Cooper, James, D’Agati, Vivette D., Damm, Tiffany L., Davies, Simon J., Davis, Scott, de Boer, Ian H., De Vriese, An S., Derman, Wayne, Drekonja, Dimitri M., Eckardt, Kai-Uwe, Elger, Marlies, Elliott, William J., Ellison, David H., Emmett, Michael, Evenepoel, Pieter, Falk, Ronald J., Fayed, Tarek S., Fermand, Jean-Paul, Fernandez, Javier, Fervenza, Fernando C., Fishbein, Lauren, Fisher, Molly, Floege, Jürgen, Fogazzi, Giovanni B., Foreman, John W., Free, Meghan, Gallagher, Kevin M., Garcia-Trabanino, Ramon, Garigali, Giuseppe, Georgianos, Panagiotis I., Girndt, Matthias, Glassock, Richard, Gorelick, Philip B., Grams, Morgan, Greco, Barbara Ann, Griffith, Megan, Guay-Woodford, Lisa Marie, Harris, Peter C., Heine, Gunnar Henrik, Herzog, Charles A., Hildebrandt, Friedhelm, Harmon, William E., Hooton, Thomas, Houillier, Pascal, Hughes, Jeremy, Inker, Lesley A., Irish, Ashley B., Jain, Koyal, Jefferson, Jonathan Ashley, Jennette, John Charles, Jha, Vivek, Johnson, Richard J., Wilshire Jones, Erika Sherad, Jones, Terry, Judd, Eric, Juncos, Luis A., Kalantar-Zadeh, Kamyar, Kalantari, Kambiz, Kanagasundaram, Nigel Suren, Kanellis, John, Karakala, Nithin, Kashkouli, Ali, Kashtan, Clifford E., Kauffman, Carol A., Kennedy, Claire, Kerr, Peter G., Kestenbaum, Bryan, Ketteler, Markus, Kopp, Jeffrey Burnett, Koratala, Abhilash, Kotanko, Peter, Kriz, Wilhelm, Kuhlmann, Martin K., Kumar, Reeti, Kuypers, Dirk R., Leung, Nelson, Levey, Andrew S., Levin, Nathan W., Levy, Jeremy, Lewington, Andrew, Li, Jennifer, Li, Li, Limonte, Christine P., Linas, Stuart L., Lok, Charmaine E., Macdougall, Iain C., Macedo, Etienne, MacGinley, Robert, Madero, Magdalena M., Magee, Colm, Malvar, Ana, Marshall, Mark, Marx, Nikolaus, Mathews, Ranjiv, Mattoo, Tej K., McCulloch, Mignon Irene, McDonald, Stephen Peter, Mellon, John, Miceli, Marisa H., Mirkov, Sanja, Morath, Christian, Fonseca, Nuno Moreira, Mulley, William R., Murtagh, Fliss, Mühlfeld, Anja Susanne, Nangaku, Masaomi, Nast, Cynthia C., Navarro, David, Neild, Guy H., Nicholson, Michael, Noris, Marina, O’Neill, W. Charles, Paine, Cary, Palmer, Biff F., Pannu, Neesh, Perazella, Mark A., Perico, Norberto, Pham, Phuong-Anh T., Pham, Phuong-Chi T., Pham, Phuong-Thu, Pham, Son, Phelps, Richard G., Pickering, Matthew, Polkinghorne, Kevan, Radhakrishnan, Jai, Rayner, Brian, Rayner, Hugh C., Reich, Heather N., Remuzzi, Giuseppe, DeMauro Renaghan, Amanda, Rheault, Michelle, Richards, A. Mark, Riella, Leonardo, Rodriguez-Iturbe, Bernardo, Ronco, Pierre, Rosenberg, Avi Z., Rosner, Mitchell, Ross, Michael, Rossert, Jerome, Rovin, Brad H., Ruggenenti, Piero L., Salant, David J., Samuels, Martin A., Sanders, Paul W., Sands, Jeff M., Santoriello, Dominick, Sarafidis, Pantelis, Schaenman, Joanna M., Schneider, Ronen, Segal, Mark S., Seifter, Julian Lawrence, Seneschall, Charlotte, Sethi, Sanjeev, Sharma, Kumar, Sharpe, Claire, Speer, Claudius, Sreelatha, M., Sridhar, Vikas S., Srisawat, Nattachai, Stenvinkel, Peter, Stites, Erik, Szerlip, Harold M., Tanaka, Tetsuhiro, Tang, Sydney C.W., Thomas, Chandra, Thurman, Joshua, Tonelli, Marcello, Tong, Li-Li, Topham, Peter S., Tordoir, Jan H.M., Torres, Vicente E., Touchard, Guy, Turner, Neil, Unwin, Robert John, Velez, Juan Carlos Q., Vervloet, Marc, Visweswaran, R. Kasi, Wanner, Christoph, Warner, Ross, Wasse, Haimanot, Weiner, I. David, Wheeler, David C., Wiles, Kate, Wilkie, Martin, Williams, Bryan, Wingo, Charles S., Wiseman, Alexander C., Womer, Karl L., Wong, Germaine, Wyld, Melanie, Wymer, David T.G., Wymer, David C., Yu, Xueqing, Zanella, Monica, Zeier, Martin, and Zhang, Hong

Published
2024
Full Text
View/download PDF

37. An Overview of Solid Organ Transplantation in Patients With Sickle Cell Disease

Author

Sharpe, Claire C., Suddle, Abid, and Stuart-Smith, Sara

Abstract

Sickle cell disease is a common genetic disorder affecting >300 000 people across the world. The vast majority of patients cared for in high-resource settings live well into adulthood, but many develop a high burden of disease complications. Good standard of care including disease-modifying agents and transfusion programs limits the number of patients who develop end-stage organ disease, but for those that do, the prognosis can be very poor. Solid organ transplantation is a well-established mode of treatment for patients with sickle cell disease and kidney or liver failure, but appropriate patient selection and perioperative management are important for achieving good outcomes. Hematopoietic stem cell transplantation and gene therapy may offer novel treatment options for adult patients with chronic organ damage in the future, but these are not yet widely available. For now, good, holistic care and early intervention of end-organ complications can minimize the number of patients requiring solid organ transplantation later in life.

Published
2023
Full Text
View/download PDF

42. Estimated glomerular filtration rate equations in people of self-reported black ethnicity in the United Kingdom: Inappropriate adjustment for ethnicity may lead to reduced access to care

Author

Gama, Rouvick M., primary, Clery, Amanda, additional, Griffiths, Kathryn, additional, Heraghty, Neil, additional, Peters, Adrien M., additional, Palmer, Kieran, additional, Kibble, Henry, additional, Vincent, Royce P., additional, Sharpe, Claire C., additional, Cairns, Hugh, additional, and Bramham, Kate, additional

Published
2021
Full Text
View/download PDF

43. Outcome and effect of vaccination in SARS-CoV-2 Omicron infection in hemodialysis patients: a cohort study.

Author

Ashby, Damien R, Caplin, Ben, Corbett, Richard W, Asgari, Elham, Kumar, Nicola, Sarnowski, Alexander, Hull, Richard, Makanjuola, David, Cole, Nicholas, Chen, Jian, Nyberg, Sofia, Forbes, Suzanne, McCafferty, Kieran, Zaman, Faryal, Cairns, Hugh, Sharpe, Claire, Bramham, Kate, Motallebzadeh, Reza, Anwari, Kashif, and Roper, Tayeba

Subjects
SARS-CoV-2 Omicron variant, HEMODIALYSIS patients, SARS-CoV-2, VACCINE effectiveness, PROPORTIONAL hazards models
Abstract

Background Hemodialysis patients are at high risk of Covid-19, though vaccination has significant efficacy in preventing and reducing the severity of infection. Little information is available on disease severity and vaccine efficacy since the dissemination of the Omicron variant. Methods In a multi-center study, during a period of the epidemic driven by the Omicron variant, all hemodialysis patients positive for SARS-CoV-2 were identified. Outcomes were analyzed according to predictor variables including vaccination status. Risk of infection was analyzed using a Cox proportional hazards model. Results SARS-CoV-2 infection was identified in 1126 patients including 200 (18%) unvaccinated, 56 (5%) post first dose, 433 (38%) post second dose, and 437 (39%) at least 7 days beyond their third dose. The majority of patients had a mild course but 160 (14%) were hospitalized and 28 (2%) died. In regression models adjusted for age and comorbidity, two-dose vaccination was associated with a 39% (95%CI: 2%–62%) reduction in admissions, but third doses provided additional protection, with a 51% (95%CI: 25%–69%) further reduction in admissions. Among 1265 patients at risk at the start of the observation period, SARS-CoV-2 infection was observed in 211 (17%). Two-dose vaccination was associated with a 41% (95%CI: 3%–64%) reduction in the incidence of infection, with no clear additional effect provided by third doses. Conclusions These data demonstrate lower incidence of SARS-CoV-2 infection after vaccination in dialysis patients during an Omicron dominant period of the epidemic. Among those developing infection, severe illness was less common with prior vaccination, particularly after third vaccine doses. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

44. Additional file 1 of COVID-19-related acute kidney injury; incidence, risk factors and outcomes in a large UK cohort

Author

Jewell, Paul D., Bramham, Kate, Galloway, James, Post, Frank, Norton, Sam, Teo, James, Fisher, Richard, Saha, Rohit, Hutchings, Sam, Hopkins, Phil, Smith, Priscilla, Joslin, Jennifer, Jayawardene, Satish, Mackie, Sarah, Mudhaffer, Ali, Holloway, Amelia, Kibble, Henry, Akter, Mosammat, Zuckerman, Benjamin, Palmer, Kieran, Murphy, Ciara, Iatropoulou, Domniki, Sharpe, Claire C., and Lioudaki, Eirini

Abstract

Additional file 1. (PPTX 62 kb)

Published
2021
Full Text
View/download PDF

45. COVID-19-related acute kidney injury; temporal changes in incidence rate and outcomes in a large UK cohort

Author

Jewell, Paul D., primary, Bramham, Kate, additional, Galloway, James, additional, Post, Frank, additional, Norton, Sam, additional, Teo, James, additional, Fisher, Richard, additional, Saha, Rohit, additional, Hutchings, Sam, additional, Hopkins, Phil, additional, Smith, Priscilla, additional, Joslin, Jennifer, additional, Jayawardene, Satish, additional, Mackie, Sarah, additional, Mudhaffer, Ali, additional, Holloway, Amelia, additional, Kibble, Henry, additional, Akter, Mosammat, additional, Zuckerman, Benjamin, additional, Palmer, Kieran, additional, Murphy, Ciara, additional, Iatropoulou, Domniki, additional, Sharpe, Claire C., additional, and Lioudaki, Eirini, additional

Published
2021
Full Text
View/download PDF

46. Is point-of-care testing feasible and safe in care homes in England? An exploratory usability and accuracy evaluation of a point-of-care polymerase chain reaction test for SARS-CoV-2

Author

Micocci, Massimo, primary, Gordon, Adam L, additional, Seo, Mikyung Kelly, additional, Allen, A Joy, additional, Davies, Kerrie, additional, Lasserson, Dan, additional, Thompson, Carl, additional, Spilsbury, Karen, additional, Akrill, Cyd, additional, Heath, Ros, additional, Astle, Anita, additional, Sharpe, Claire, additional, Perera, Rafael, additional, Hayward, Gail, additional, and Buckle, Peter, additional

Published
2021
Full Text
View/download PDF

47. Is Point-of-Care testing feasible and safe in care homes in England? An exploratory usability and accuracy evaluation of Point-of-Care Polymerase Chain Reaction test for SARS-COV-2

Author

Micocci, Massimo, primary, Gordon, Adam, additional, Seo, Mikyung Kelly, additional, Allen, Joy A, additional, Davies, Kerrie, additional, Lasserson, Dan, additional, Thompson, Carl, additional, Spilsbury, Karen, additional, Akrill, Cyd, additional, Heath, Ros, additional, Astle, Anita, additional, Sharpe, Claire, additional, Perera, Rafael, additional, Hayward, Gail, additional, and Buckle, Peter, additional

Published
2020
Full Text
View/download PDF

48. Additional file 1 of Ion-Channel modulator TH1177 reduces glomerular injury and serum creatinine in chronic mesangial proliferative disease in rats

Author

Cove-Smith, Andrea, Sharpe, Claire C., Shattock, Michael J., and Hendry, Bruce M.

Subjects
urologic and male genital diseases
Abstract

Additional file 1: Supplementary Fig. 1. PAS histology of the chronic Thy1 model at days 7, 14, 28 and 42. There is progressive glomerular hypercellularity as quantified in the lower panel. Supplementary Fig. 2. ED1 stain for monocyte/macrophages in the chronic Thy1 model at days 7,14, 28 and 42. Scale bars are 100 μm. There is an early inflammatory increase in ED1 positive cells at day 7. This tends to reduce with few ED1 positive cells in the glomeruli at day 42 of the model. Supplementary Fig. 3. Ki-67 stain of the Chronic Thy1 model as an estimate of cellular proliferation with quantification in the chart at the right. Scale bars are 100 μm. The disease model shows an increase in Ki67 stain at day 28 with later resolution so that there is no difference between disease and vehicle controls by day 42. Supplementary Fig. 4 Plot of serum creatinine against body weight at Day 42 in the therapeutic experiment on the chronic Thy1 model. There was no significant correlation seen.

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results