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In-home or food service antimicrobial treatment options for fresh produce are limited. Hot water treatments for whole (unpeeled) produce have been proposed, but data to support this practice for onions are not available. Separate cocktails of rifampin-resistant Escherichia coli O157:H7, Listeria monocytogenes, and Salmonella were cultured on agar and suspended in sterile water. The outer papery skin at the equator or root or stem ends of the whole yellow onions was spot inoculated at 6 log CFU per onion. After drying for 30 min and, in some cases, storage at 4°C for 6 days, onions were immersed in water at ca. 100°C for 5 s or 85°C for 10 to 180 s. No significant difference (P > 0.05) in the mean decline of Salmonella was found on onions that were exposed to hot water after drying the inoculum for 30 min or after storage at 4°C for 6 days. Exposure of whole onions at 100°C for 5 s reduced E. coli O157:H7 and L. monocytogenes populations by >5 log CFU per onion at all inoculum sites and Salmonella populations by >5 log CFU per onion at the stem end and equator but not consistently at the root end. Mean root-end reductions of ≥5 log CFU per onion of E. coli O157:H7, L. monocytogenes, and Salmonella were achieved consistently when the root end was fully immersed in 85°C hot water for 45 or 60 s except in a small number of cases (4 of 57; 7%) when the root end was oriented upward and above the water line during treatment. When onions were held at 85°C for 180 s with the root end above the water line in an uncovered water bath, no significant declines in Salmonella populations were observed; significant mean declines in Salmonella were achieved (mean, 5 log CFU per onion; range, 3.49 to 6.25 log CFU per onion) when the water bath was covered. Short exposure to hot water can significantly reduce pathogens on the surface of whole onions. Reductions are more consistent when the root end is submerged and when the water bath is covered. HIGHLIGHTS

High reproductive power and short development cycle, in addition to other factors, enable D.gallinae to produce adverse effects in the poultry industry. Not all development stages have the same significance, nor are they equally sensitive to the methods and formulations used for D.gallinae control. Laboratory tests were conducted by exposing eggs, larvae and protonymphs to P 547/17 formulation of inert oils (Pulcap). The testing was carried out with 20% oil-in-water emulsion with short exposure (1 min), and with 10%, 20%, 50% and 100% oil-in-water emulsion with continuous exposure. In the first control group, water was used (with continuous exposure), and in the other control group, eggs, larvae and nymphs were not treated. We determined that in all cases, eggs were laid in high percentage (89-100%). In addition to this, in tested liquids, larvae were present in high percentage and they change into protonymphs (8-89%). In the conditions of full exposure, where parasitic stages cannot leave the emulsion, P 547/17 in time achieves complete efficacy on development stages. In short exposure of eggs, when dirt is present, or on absorbent surfaces, P 547/17 emulsion cannot control them. However, this flaw is not essential in practical conditions. When applied correctly, P 547/17 formulation is efficient in D.gallinae control.

The oxidation behavior of four γ/γ′ Ni-based alloys: without additions, and containing: Hf (1.0 wt%), a combination of Hf and Y (0.3 wt% and 0.03 wt%, respectively), and a combination of Hf and Si (1.0 wt% and 1.0 wt%, respectively) was studied in air under isothermal (50 h) and thermal cycling (up to 2225 1-h cycles) conditions. Samples were characterized using SEM, EDX and XRD techniques. The results indicated that all the additions improved the oxidation resistance of the alloy but only in the case of materials containing the (Hf + Y) combination of additions was a long-term effect achieved. Substantial weight losses were observed on the other unmodified and (Hf + Si)-containing materials during thermal cycling after short exposure periods, while on material containing only additions of Hf, they occurred significantly later. Kinetic studies showed the highest oxidation rate in the case of the (Hf + Si)-containing alloys and the fastest initial oxidation, prior to the parabolic law-obeying stage, of alloy with Hf-additions, only. The results indicate the superior effect of simultaneous application of Hf and Y additions at levels not exceeding their solubility limits and that lowering its effectiveness Hf overdoping (1 wt%) cannot be effectively counteracted by the addition of 1% Si.

Few minutes of hypoxic exposure stabilizes hypoxia-inducible factor-1α, resulting in erythropoietin (EPO) gene transcription and production. The objective of this study was to identify the shortest intermittent hypoxia protocol necessary to increase serum EPO levels in healthy individuals. In a first experiment, spontaneous EPO changes under normoxia (NORM) and the EPO response to five 4-min cycles of intermittent hypoxia (IH5) were determined in six individuals. In a second experiment, the EPO response to eight 4-min cycles of intermittent hypoxia (IH8) and 120 min of continuous hypoxia (CONT) was determined in six individuals. All hypoxic protocols were performed at a targeted arterial oxygen saturation of 80%. There was no significant change in EPO levels in response to normoxia or in response to five cycles of intermittent hypoxia (NORM: 9.5 ± 1.8 to 10.5 ± 1.8, IH5: 11.4 ± 2.3 to 13.4 ± 2.1 mU/mL, main effect for time

Ultrafast Ca2+ imaging using low-affinity fluorescent indicators allows the precise measurement of the kinetics of fast Ca2+ currents mediated by voltage-gated Ca2+ channels. Thus far, only a few indicators provided fluorescence transients with sufficient signal-to-noise ratio necessary to achieve this measurement, with Oregon Green BAPTA-5N exhibiting the best performance. Here we evaluated the performance of the low-affinity Ca2+ indicator Cal-520FF to record fast Ca2+ signals and to measure the kinetics of Ca2+ currents. Compared to Oregon Green BAPTA-5N and to Fluo4FF, Cal-520FF offers a superior signal-to-noise-ratio providing the optimal characteristics for this important type of biophysical measurement. This ability is the result of a relatively high fluorescence at zero Ca2+, necessary to detect enough photons at short exposure windows, and a high dynamic range leading to large fluorescence transients associated with short Ca2+ influx periods. We conclude that Cal-520FF is at present the optimal commercial low-affinity Ca2+ indicator for ultrafast Ca2+ imaging applications.

The efficiency of retrieval of images distorted by atmospheric turbulence formed by single- and multiaperture systems is analyzed. It is shown in numerical simulation that the use of multiaperture observation systems for computer correction of atmospheric distortions under anisoplanatism can significantly reduce the exposure time. The main distortions are well corrected when imaging for a short exposure time, which corresponds to the case of a “frozen” turbulent medium. Correction of residual small-scale distortions requires an-order-of-magnitude shorter time than in the case of long-exposure imaging with the use of common single-aperture observation systems.

To evaluate the influence of light emitted from two Polywave®, LED light-curing units (LCU) on in vivo pulp temperature (PT) rise and signs of acute inflammatory response in pulps of human premolar having deep Class V preparations.Sixty intact, first premolars from 15 volunteers requiring extraction received infiltrative anesthesia. A sterile thermocouple probe was inserted within the pulp tissue through a minute occlusal pulp exposure in only 45 teeth (n = 9) to continuously monitor PT (°C). A deep buccal Class V preparation was created, and the surface was exposed to light from a commercial Polywave LCU (Bluephase 20i (20i), Ivoclar Vivadent) or from an experimental LCU (Exp) using the exposure modes (EM): 1s/Exp and 2s/Exp, 10s/20i, 20s/20i, and 60s/20i. Peak PT and PT rise values above baseline (ΔT) data were evaluated using a one-way ANOVA followed by Tukey's post-hoc test (α = 5%). Teeth used for histological and immunohistochemical analyses (n = 3) were extracted approximately 2 h after exposure to the LCU.No significant difference in peak PT and ΔT values was noted between 2s/Exp and 20s/20i groups, which both exhibited higher values than 1s/Exp and 10s/20i groups (p0.001). Dilated and congested blood vessels were seen after exposure to 1s/Exp, 2s/Exp, or 60s/20i EMs. The expression of IL-1β and TNF-α tended to be more intense when higher irradiance was delivered.Although higher irradiance delivered over a short exposure caused lower PT rise than 5.5 °C, such EMs should be used with caution, as they have more potential to harm the pulp tissue.

The search for radioprotectors is an ambitious goal with many practical applications. Particularly, the improvement of human radioresistance for space is an important task, which comes into view with the recent successes in the space industry. Currently, all radioprotective drugs can be divided into two large groups differing in their effectiveness depending on the type of exposure. The first of these is radioprotectors, highly effective for pulsed, and some types of relatively short exposure to irradiation. The second group consists of long-acting radioprotectors. These drugs are effective for prolonged and fractionated irradiation. They also protect against impulse exposure to ionizing radiation, but to a lesser extent than short-acting radioprotectors. Creating a database on radioprotectors is a necessity dictated by the modern development of science and technology. We have created an open database, Radioprotectors.org, containing an up-to-date list of substances with proven radioprotective properties. All radioprotectors are annotated with relevant chemical and biological information, including transcriptomic data, and can be filtered according to their properties. Additionally, the performed transcriptomics analysis has revealed specific transcriptomic profiles of radioprotectors, which should facilitate the search for potent radioprotectors.

Several studies have demonstrated translational potential of the zebrafish in modeling fetal alcohol spectrum disorders (FASDs), including the less severe forms of this disease. Short exposure to even low doses of alcohol during embryonic development has been shown to disrupt behavior, alter neurochemistry, and expression of neuronal markers and glial cell phenotypes in zebrafish. However, no study to date has systematically analyzed the potential morphological effects of the short- and low-dose embryonic alcohol exposure regimen used before with zebrafish to model milder forms of human FASD. In this study, we use this previously used embryonic alcohol exposure regimen. We immerse intact zebrafish eggs of AB strain and of a genetically variable wild-type population for 2 h into 1% or 0% (vol/vol) ethanol bath at one of five developmental stages (8, 16, 24, 32, or 40 h postfertilization). At 8 days postfertilization, we quantify body length and width and eye diameter of the larvae. We report nonsignificant effects of embryonic alcohol exposure used at all developmental stages in both populations of zebrafish. Our results confirm that visual perception or motor function is unlikely to have contributed to previously reported behavioral abnormalities resulting from embryonic alcohol exposure in zebrafish.

Hydatidosis is a zoonotic disease that commonly occurs in several places around the world, especially in the Middle East, due to infection by the larval stage of Echinococcus granulosus. This disease impacts an immense effect on the economic and public health of both humans and animals. Despite their effectiveness, the unacceptable side effects and progressive resistance to scolicidal agents may limit their use. According to their biopharmaceutical activity and benefits, numerous studies have reported that scorpion venom and its derivatives represent important resources for therapeutic applications. Therefore, this study was designed to investigate the in vitro scolicidal consequences of the crude venom of Androctonus crassicauda on E. granulosus. For this purpose, protoscolices from infected organs of camel containing hydatid cysts were collected, separated, and washed. The scolicidal impacts of three different concentrations of the crude venom (20, 50, and 100 µg/mL) were tested at different times of exposure (30, 60, 120, and 240 min). Particularly, eosin exclusion test was used to examine the viability of the protoscolices. The study results showed that the crude venom at 100 μg/mL destroys all protoscolices after 240 min incubation. Also, the scolicidal activity of venom increased significantly according to the time of exposure. In conclusion, the crude venom of A. crassicauda demonstrated high scolicidal activity in vitro against protoscolices of hydatid cysts in low concentration and short exposure time. However, the efficacy of scorpion venom remains to be evaluated in vivo for the treatment of hydatidosis in both humans and domesticated animals.

In his search to create ‘instantaneously capturable’ paintings, Frank Stella started to use Day-Glo alkyd paints as a vehicle to communicate his simple, striped designs. Up till now, art criticism has neglected the visual impact of these fluorescent colours on this concept of ‘instantaneous art’. By presenting participants with Stella’s designs (fluorescent and conventional variants) for short presentation times (8 to 12 ms), we aimed to find out whether fluorescent colour combinations are seen faster (i.e. yield better performance in identifying the specific design) than their conventional counterparts. In general, participants were very good in identifying the correct design among distractors, which means that the pattern and colour combinations based on Stella’s work do seem to be ‘instantaneously capturable’. However, Stella’s formula for ‘instantaneous’ paintings is not identical for the different combinations. When exploring fluorescence in combination with other aspects of the design (colour and pattern), we found two effects that seemed to predict performance. First, performance seemed to depend on specific design patterns. Second, fluorescence seemed to interact with specific colour combinations in predicting performance. The red-yellow designs yielded better performance for the fluorescent variants, while the opposite was found for the green-orange designs. Contrast differences in luminance between the two colours of each colour combination might explain part of the results. On the other hand, the effect of fluorescent colours might have been watered down by the confusion between the hand printed fluorescent colours and the computer display used for the identification task, which only showed conventional colours. epub ahead of print ispartof: Art and Perception vol:8 issue:2 status: Published online

Although Chimeric Antigen Receptor (CAR) T cells have been proven to be powerful in eradicating tumors. However, its non-specific activity against normal tissues and cells has been a major problem. Here, utilizing the activation of transient receptor potential cation channel subfamily V member 1 (TRPV1) under heat, the translocation of nuclear factor of activated T-cells (NFAT) triggered by Calcium influx, and the recombination effects of Cre-lox system, we have developed a system to remotely manipulate the expression of proteins in cells under the control of both heat and drugs. The significance of this project is to provide a method to precisely control the activities of CAR T cells within targeted local tissues.

BackgroundThe SARS-CoV-2 pandemic urges for cheap, reliable, and rapid technologies for disinfection and decontamination. One frequently proposed method is UV-C irradiation. However, UV-C doses necessary to achieve inactivation of high-titer SARS-CoV-2 are poorly defined.MethodsUsing a box and two handheld systems designed to decontaminate objects and surfaces we evaluated the efficacy of 254 nm UV-C treatment to inactivate surface dried SARS-CoV-2.ResultsDrying for two hours did not have a major impact on the infectivity of SARS-CoV-2, indicating that exhaled virus in droplets or aerosols stays infectious on surfaces at least for a certain amount of time. Short exposure of high titer surface dried virus (3-5*10^6 IU/ml) with UV-C light (16 mJ/cm2) resulted in a total inactivation of SARS-CoV-2. Dose-dependency experiments revealed that 3.5 mJ/cm2 were still effective to achieve a > 6-log reduction in viral titers whereas 1.75 mJ/cm2 lowered infectivity only by one order of magnitude.ConclusionsOur results demonstrate that SARS-CoV-2 is rapidly inactivated by relatively low doses of UV-C irradiation. Furthermore, the data reveal that the relationship between UV-C dose and log-viral titer reduction of surface residing SARS-CoV-2 is non-linear. In the context of UV-C-based technologies used to disinfect surfaces, our findings emphasize the necessity to assure sufficient and complete exposure of all relevant areas by integrated UV-C doses of at least 3.5 mJ/cm2 at 254 nm. Altogether, UV-C treatment is an effective non-chemical possibility to decontaminate surfaces from high-titer infectious SARS-CoV-2.

People are more likely to believe things that are easier to process. Foreign-accented speech is relatively difficult to process, and prior research shows that, correspondingly, people believe information less when it is delivered in a foreign accent rather than a native accent. Here we show that a short exposure to foreign accent can reduce this bias, and that the reduction in bias is due to improvement in the processing of the accent. These results demonstrate how cognitive aspects of language processing can influence attitudes. The results also suggest that ensuring exposure to foreign accent can reduce discrimination against nonnative speakers.

Individuals can perceive the mean emotion or mean identity of a group of faces. It has been considered that individual representations are discarded when extracting a mean representation; for example, the “element-independent assumption” asserts that the extraction of a mean representation does not depend on recognizing or remembering individual items. The “element-dependent assumption” proposes that the extraction of a mean representation is closely connected to the processing of individual items. The processing mechanism of mean representations and individual representations remains unclear. The present study used a classic member-identification paradigm and manipulated the exposure time and set size to investigate the effect of attentional resources allocated to individual faces on the processing of both the mean emotion representation and individual representations in a set and the relationship between the two types of representations. The results showed that while the precision of individual representations was affected by attentional resources, the precision of the mean emotion representation did not change with it. Our results indicate that two different pathways may exist for extracting a mean emotion representation and individual representations and that the extraction of a mean emotion representation may have higher priority. Moreover, we found that individual faces in a group could be processed to a certain extent even under extremely short exposure time and that the precision of individual representations was relatively poor but individual representations were not discarded.

Quality degradation due to inappropriate postharvest handling, including short exposure to high and variable temperature environments and cooling delay, is a critical issue for maintaining the freshness of vegetables and fruits in further marketing chains and final consumption. The goal of this research was to explore the influence of delayed cooling treatments on key quality attributes of tomatoes such as fresh weight, total soluble solids (TSS), firmness, and skin color (L*, a*, and a*/b*). Three treatments were applied to freshly harvested tomatoes: immediate storage (IS) after harvest, delayed cooling (DS) leaving tomatoes without cover for one day, and under cover (DSC) separately in a greenhouse and then storage in a controlled chamber at a temperature of 10 ± 1 ℃ and relative humidity of 90 ± 3%. The quality attributes of the stored tomatoes were examined for 15 storage days at 5-day intervals to examine the effects of cooling delay on the postharvest quality of tomatoes stored in a controlled chamber. After 15 days of storage, tomatoes that underwent the three treatments exhibited a progressive weight loss of 1.41%, 1.86%, and 1.69% for the IS, DS, and DSC treatments, respectively. Slower firmness reduction (31.2%) was observed for tomatoes with the IS treatment than for those with the other treatments over the storage duration. During the storage time, tomatoes that experienced the DS treatment exhibited higher increases in TSS (°Bx) values (4.79 to 5.76) than other tomato samples. Smaller changes in color values (L*, a*, and a*/b*) were observed for IS-treated tomatoes. During the storage time, overall changes were slower for IS-treated tomato samples than for those with other treatments. The results of this research indicate that the accumulation of field heat due to cooling delay could decrease the overall quality attributes of tomatoes in the market chain. The immediate transfer of harvested tomatoes to a cool temperature is strongly recommended.

This work considers the magnetic induction method on rough surfaces (ABNT NBR 10443) to determine the thickness of the patina layer formed on weathering steel (WS) sheets exposed for up to two years at São Paulo atmosphere and on WS sculptures exposed for sixteen and twenty-four years at the same site. A good agreement was found with SEM measurements. It was also found that patina thickening followed a two slopes bilogarithmic law, with a steeper slope for short exposure periods, in agreement with increased corrosion rate. For long-term exposure, it was found a low thickening rate (

Some manufactures made UVC LED Strip as disinfection tool against SARS-CoV2 Therefore, three types of commercially UVC lights were used to evaluate their efficiency to warp bacteria and viruses We tested three commercially available UV lights devices They were put at 4 to 5 cm to spiked sterile Petri dishes (samples) for 10, 20, 30, and 60 seconds and compared it to control (without UV light exposure) Also, the same three UV LED devices were used on Positive SARS-CoV2 swab samples (used for the Petri dishes) Serial dilutions of the cultured microbes were used for the experiment as follows: 1/10 (high concentration), 1/100, 1/1000, 1/10,000, 1/100,000 (low concentration) All three UV LED devices (DA, DB, DC) were found to have no effects on the pathogens (Bacteria or SARS-CoV2), even to the lowest Bacteria Concentration (1/100,000), when pathogens were exposed to UV radiation for 10, 20, 30, and 60 sec at distance a 4 to 5 cm One of the manufacturers of these UVC lights (DB) claims that the device is very effective in killing Bacteria and Virus immediately at a 99 93% killing rate (in 20 sec ) This observation was not noticed False claims may lead to severe spread of SARS-CoV2 as customers may think that the DB was disinfecting, after short exposure, while truly having no effect

In 2017, the US Food and Drug Administration warned that exposure to anesthetic medicines for lengthy periods of time or over multiple surgeries may affect brain development in children aged less than 3 years. Since then, the clinical literature continues to find mixed evidence of pediatric anesthesia-related neurotoxicity. However, several new human studies provide strong evidence that a single short exposure to general anesthesia in young children does not cause detectable neurocognitive injury by neuropsychological testing. These newer findings are reassuring, but cannot be extrapolated to children who are deemed to be at highest risk of neurologic injury after anesthesia.

Purpose In rodents, dextran sulfate sodium (DSS)-induced diarrhea and colonic inflammation have similar symptoms to those of ulcerative colitis in humans. We examined the effects of exposure to mild hyperbaric oxygen (MHO) at an atmospheric pressure of 1317 hPa with 40% oxygen on DSS-induced diarrhea and colonic inflammation in rats. Methods Five-week-old male Kyoto Apc Delta (KAD) rats (n = 12) were administered 2% DSS through drinking water for 1 week. Subsequently, DSS-treated male rats were not subjected to any further treatment (n = 6) or exposed to MHO (n = 6) for 2 weeks. Age-matched KAD rats not subjected to DSS treatment or exposed to MHO were used as the control group (n = 6). Results Control rats did not exhibit diarrhea and colonic inflammation. However, DSS-treated rats exhibited diarrhea and colonic inflammation, regardless of exposure to MHO. Exposure to MHO for 2 weeks led to decreased incidence of diarrhea in DSS-treated rats (p < 0.05). Exposure to MHO had no effect on colonic inflammation in DSS-treated rats (p = 0.12). Conclusion Exposure to MHO for 2 weeks can improve diarrhea but cannot attenuate colonic inflammation, possibly due to the short exposure duration (2 weeks) used in this study.

To investigate the effect of atmospheric corrosion on the fatigue properties of 2024-T4 aluminum alloy structures during the whole corrosion period, atmospheric and accelerated pre-corrosion fatigue tests were carried out. Field exposure tests were carried out for 7, 12, and 20 years. A laboratory accelerated corrosion test method was proposed to simulate the whole atmospheric corrosion period from initial pitting to the subsequent exfoliation corrosion, and the reliability was verified through an analysis of the corrosion morphology, corrosion products, and thickness variation. Pitting and intergranular corrosion occurred after a short exposure to atmospheric corrosion, and intergranular corrosion was the dominant corrosion damage mode. The fatigue cracks initiated at the deepest boundary of intergranular corrosion. The fatigue life decreased dramatically during the initial stage of atmospheric corrosion and then decreased more slowly. Finally, the mechanism through which atmospheric corrosion affected the fatigue properties was analyzed.

Professional long drivers can hit golf balls to a speed of up to 350 km/h. Extremely short exposure time is required to capture the objects moving that fast without blur. The very high frame rate is also required to capture the sufficient sequence of object movements within the field of view in order to predict trajectory, which means a sacrifice in frame image resolution at fixed data throughput. This paper presents a high-speed stereo vision system that is able to track the golf ball motion at the speed of up to 360 km/h under normal indoor lighting conditions. Binocular camera operated at 810 frames/s with 35- $\mu \text{s}$ exposure time, requiring no additional strobe lights in order not to compromise user experiences. Ball markers were designed for spin measurement. To detect balls and identify markers from highly underexposed low resolution images, new algorithms were developed and implemented on field-programmable gate array board with an advanced RISC machines CPU. The experimental results showed high detection rate and high accuracy with overall processing time less than 300 ms.

Listeria monocytogenes has been implicated in many foodborne outbreaks involving fresh produce such as lettuce. In order to contaminate the lettuce, the pathogen must attach to the fresh produce. In this study, the attachment of L. monocytogenes strains O8A06, O8A07 and O8A08 to hydroponically grown lettuce as well as lettuce grown with a soil potting mix was evaluated under different exposure times (1 s, 10 s, 30 s, 60 s, 2 min and 5 min). Attachment of L. monocytogenes O8A08 to hydroponically grown lettuce leaves during 2 and 5 min exposure times was significantly higher (p 0.05) in Listeria attachment to both hydroponic and soil grown lettuce leaves as well as the number attaching to lettuce between the different exposures times tested. The number of L. monocytogenes which attached to both soil and hydroponically grown lettuce leaves within these short exposure times for all the three strains ranged from 0.77 to 1.46 log CFU/cm2. The results indicate that any exposure of lettuce leaves to a source of L. monocytogenes may result in rapid colonisation of the product and therefore, prevention of fresh produce contamination by L. monocytogenes is more important than depending on other control systems to remove contamination.

In an era when it was not possible to achieve quality x-rays with short exposure times, the need to obtain chest images without movement led the French doctor Emre Hyacinthe Guilleminot to construct a machine that repeatedly emitted x-rays only when desired during the respiratory cycle. His aim was to create a satisfactory radiograph from multiple short bursts performed at the moment of inhalation or exhalation, based on Charles Bouchard's research on heart disease. He extended his idea to radiography of the heart, creating a system that enabled images to be obtained disassociating the phases of heartbeat. This article seeks to explain the basic functioning of these mechanisms, and to recover previous research papers that led to their creation. We will also retrieve biographical and personal data of the two people involved - one directly, the other indirectly - in these novel inventions.

Sensory representations are constantly realigned. For instance, in the ventriloquism aftereffect, short exposure to audiovisual stimuli with a consistent spatial disparity results in an adjustment of auditory spatial representations. Here we tested whether repeated audiovisual training over several sessions enhances recalibration in the ventriloquism aftereffect. One group of participants (n = 16) received incremental training in which the presented degree of audiovisual spatial disparity increased over the course of 3 days, whereas a second group (n = 16) was constantly exposed to the largest disparity during all three sessions (constant training). Within each session, a significant ventriloquism aftereffect was observed in both groups. However, the size of the final ventriloquism aftereffect was larger in the constant group, due to an increase over days that was not evident in the incremental group. These findings replicated results obtained in two prestudies that either used a smaller sample size or included constant training only. Taken together, our findings provide strong evidence that recalibration effects are retained and consolidated between sessions, contrary to the intuitive assumption that natural audiovisual stimulation outside the laboratory would immediately overwrite recalibration. Repeated training seems to be particularly effective for consistent changes in cross-modal stimulation. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

Recent achievements in the photoalignment technique for fabrication of optically rewritable electronic paper with high performance characteristics are surveyed with emphasis on temporal constraints on the exposure process. The possibility of creating electrode-free electronic paper has very important practical aspects. However, many existing studies do not include sufficient analysis on how to achieve acceptable reflective characteristics within short exposure time. In order to achieve this goal, we have applied the rotational diffusion model. We find that the parameters of the diffusion model can be adjusted to get acceptable light-reflecting characteristics within 10 s of exposure. In comparison with the long-time exposure, the reflectance coefficient reduces by 24%. The route to material improvements for optimized e-paper device is discussed.

The mechanics of collagenous soft tissues, such as skin, are sensitive to heat. Thus, quantifying and modeling thermo-mechanical coupling of skin is critical to our understanding of skin's physiology, pathophysiology, and its treatment. However, key gaps persist in our knowledge about skin's coupled thermo-mechanics. Among them, we haven't quantified the role of skin's microstructural organization in its response to superphysiological loading. To fill this gap, we conducted a comprehensive set of experiments in which we combined biaxial mechanical testing with histology and two-photon imaging under liquid heat treatment at temperatures ranging from 37∘C to 95∘C lasting between 2 seconds and 5 minutes. Among other observations, we found that unconstrained skin, when exposed to high temperatures, shrinks anisotropically with the principal direction of shrinkage being aligned with collagen's principal orientation. Additionally, we found that when skin is isometrically constrained, it produces significant forces during denaturation that are also anisotropic. Finally, we found that denaturation significantly alters the mechanical behavior of skin. For short exposure times, this alteration is reflected in a reduction of stiffness at high strains. At long exposure times, the tissue softened to a point where it became untestable. We supplemented our findings with confirmation of collagen denaturation in skin via loss of birefringence and second harmonic generation. Finally, we captured all time-, temperature-, and direction-dependent experimental findings in a hypothetical model. Thus, this work fills a fundamental gap in our current understanding of skin thermo-mechanics and will support future developments in thermal injury prevention, thermal injury management, and thermal therapeutics of skin. STATEMENT OF SIGNIFICANCE: Our work experimentally explores how skin reacts to being heated. That is, it measures how much skin shrinks, what forces it produces, and how its mechanical properties change; all as a function of temperature, but also of direction and time. Additionally, our work connects these measurements to changes in skin's microscopic make-up. This knowledge is important to our understanding of skin's function and dysfunction, especially during burn injuries or heat-dependent treatments.

While interactions with global warming and multigenerational effects are considered crucial to improve risk assessment of pesticides, these have rarely been studied in an integrated way. While heat extremes can magnify pesticide toxicity, no studies tested how their combined effects may transmit to the next generation. We exposed mosquito larvae in a full factorial, two-generation experiment to a heat spike followed by chlorpyrifos exposure. As expected, the heat spike magnified the chlorpyrifos-induced lethal and sublethal effects within both generations. Only when preceded by the heat spike, chlorpyrifos increased mortality and reduced the population growth rate. Moreover, chlorpyrifos-induced reductions in heat tolerance (CTmax), acetylcholinesterase (AChE) activity and development time were further magnified by the heat spike. Notably, when parents were exposed to chlorpyrifos, the chlorpyrifos-induced lethal and sublethal effects in the offspring were smaller, indicating increased tolerance to chlorpyrifos. In contrast, there was no such multigenerational effect for the heat spike. Despite the adaptive multigenerational effect to the pesticide, the synergism with the heat spike was still present in the offspring generation. Generally, our results provide important evidence that short exposure to pulse-like global change stressors can strongly affect organisms within and across generations, and highlight the importance of considering multigenerational effects in risk assessment. ispartof: Environmental Pollution vol:292 issue:Pt A ispartof: location:England status: published

Inhaled drugs are routinely used for the treatment of respiratory-supported patients. To date, pressurized metered dose inhalers and nebulizers are the two platforms routinely employed in the clinical setting. The scarce utilization of the dry powder inhaler (DPI) platform is partly due to the lack of in vivo data that proves optimal delivery and drug efficacy are achievable. Additionally, fitting a DPI in-line to the respiratory circuit is not as straightforward as with the other aerosol delivery platforms. Importantly, there is a common misconception that the warm and humidified inspiratory air in respiratory supports, even for a short exposure, will deteriorate powder formulation compromising its delivery and efficacy. However, some recent studies have dispelled this myth, showing successful delivery of dry powders through the humidified circuit of respiratory supports. Compared with other aerosol delivery devices, the use of DPIs during respiratory supports possesses unique advantages such as rapid delivery and high dose. In this review, we presented in vitro studies showing various setups employing commercial DPIs and effects of ventilator parameters on the aerosol delivery. Inclusion of novel DPIs was also made to illustrate characteristics of an ideal inhaler that would give high lung dose with low powder deposition loss in tracheal tubes and respiratory circuits. Clinical trials are urgently needed to confirm the benefits of administration of dry powders in ventilated patients, thus enabling translation of powder delivery into practice.

This paper evaluates the long-term impacts of the national conditional cash transfer program in the Philippines on beneficiaries who were exposed to it during a relatively short but potentially critical period of transitioning from adolescence to adulthood. The paper estimates the impacts of the Pantawid Pamilyang Pilipino Program on men and women who were enrolled in the program for up to 1.5 years when they were between ages 12.5 and 14 and are currently in their early twenties. The analysis finds evidence of impacts on marriage and fertility for women: participation in the program is associated with delay in marriage and the first birth of approximately one year and six months, respectively. No impacts are found on educational or labor market outcomes or proxies for economic welfare. Further, there is no strong and consistent evidence of changes in empowerment or gender norms.

Made available in DSpace on 2021-06-25T10:24:37Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-04-01 We assessed the short-term viability and recovery of zooplankton communities after exposure to glyphosate (active ingredient—a.i.). We conducted a hatching experiment in two steps: Step 1—natural lake sediments containing resting egg banks were placed into individual trays and exposed to a solution medium of glyphosate at three different treatments (LD = Values below the detection limits, LD < 0.05, 0.44, and 0.89 mg a.i./L) for 14 days; and Step 2—we replaced the exposure solution of glyphosate with distilled freshwater, keeping them all trays under freshwater conditions for another 14 day. The results from Step 1 showed significant effects of glyphosate on the emergence patterns of resting eggs, with a reduction in hatching of rotifers, mainly at concentrations of 0.44 and 0.89 mg a.i./L. On the other hand, the results from Step 2 showed an increase in the emergence of viable eggs for rotifers after restoration of freshwater conditions in all treatments; there was no effect for total zooplankton and microcrustaceans. These findings suggest that (i) glyphosate may, effectively, impair zooplankton hatching from resting egg banks; (ii) the magnitude of the negative effects depends on the the zooplanktonic group considered; and (iii) the restoration of freshwater conditions may, in some way, allow the recovery of the zooplankton community from viable egg banks. Our results can be useful in predicting the influence of glyphosate on the distribution patterns of freshwater zooplankton, which can represent vital information for environmental managers. Department of Biodiversity São Paulo State University (UNESP) Department of Biology Aquatic Biology Laboratory São Paulo State University (UNESP) Department of Biodiversity São Paulo State University (UNESP) Department of Biology Aquatic Biology Laboratory São Paulo State University (UNESP)

Interactions between pathogens and the symbiotic microbial communities that reside in hosts can impact disease processes. Symbiotic microbial communities can act to prevent pathogen infection in some instances, while in other instances, pathogens can disrupt these symbiotic communities. We sought to address these interactions between the fungal skin pathogen Batrachochytrium dendrobatidis (Bd) and the skin bacterial communities of adult Spring Peepers (Pseudacris crucifer). In the laboratory, frogs were exposed to Bd zoospores for a 12-hour period and then monitored for five days. Bacterial community composition on the skin was assessed upon initial collection, 24 hours post-exposure, and at the conclusion of the experiment using 16S rRNA gene amplicon sequencing. Little impact on the bacterial community was observed as a result of Bd exposure, suggesting that the timeline was either too short to observe the effects of Bd, or that the skin communities are resilient in the face of such short exposure periods. In contrast, laboratory housing was associated with changes in skin bacterial community composition, in terms of both relative abundances and bacterial taxa that were present. These findings suggest that even a short time away from their natural environment can have strong effects on the composition of amphibian skin communities and that Bd exposure may not always disrupt these skin communities.

The present study deals with photo protection benefit of Evefresh cream. Personal care industries are aggressively competing and crowding the market with wide variety of sun screeners and SPF products to offer sun protection benefit to the customers. We have used a rapid and an extremely sensitive tool- cyanotype paper to study the effect of the cream. The findings show that Evefresh cream provides photo protection and hence may be of great medical use for SLE patients to achieve photo protection from short exposure to sun. Evefresh cream being a face cream is regular use will certainly enable the users to achieve the above benefits. The paper reports the findings in detail. The findings clearly highlight in non-exaggerated manner the medical importance of Evefresh cream for SLE and actinic keratosis patients.

The present study investigates the potential of SARS-CoV-2 inactivation by a copper sulfide (CuS) incorporated three-layer mask design. The mask consisted of the outer, middle, and inner layers to give comfort, strength, shape, and safety. The outer layer contained a total of 4.4 % CuS (w/w) (2.2% CuS coated & 2.2 % CuS impregnated) nylon fibers and the middle entrapment area contain a total of 17.6% CuS (w/w) impregnated nylon. No CuS was present in the inner layer. The antiviral efficacy assessment revealed, CuS incorporated mask is highly effective in inactivating SARS-CoV-2 within 30 min exposure. After, 1h and 2 h exposure, near-complete elimination of virus were observed by cytopathy, fluorescence, and viral copy number. The antiviral activity of the mask material was derived by incorporated solid-state CuS. Noticeably, the antiviral activity of CuS against SARS-CoV-2 was in the form of solid-state CuS, but not as Cu2+ ionic form derived by dissolved CuSO4. The kinetics of droplet entrapment revealed, that the three-layered mask almost completely block virus-containing droplet pass-through for short exposure periods of 1 to 2 min, and 80% efficacy for longer exposure times of 5 to 10 min. We also demonstrated the incorporated CuS is evenly distributed all over the fibers assuring the uniformity of potential antiviral activity and proves, CuS particles are not easily shed out of the fabric fibers. The inactivation efficacy demonstrated against SARS-CoV-2 proves that the CuS incorporated three-layer mask will be a lifesaver during the present intense global pandemic.

Vacuum packed Bratwurst type cooked sausages and sliced or cubed meat products that have limited shelf-life of few days in chilled storage were HP processed (5 min, 600 MPa, 25 °C) and stored at different temperatures (0–15 °C). Color, texture, and microbiological and sensory evaluation were kinetically studied for control and HP treated samples. HP treatment did not alter the color and texture of the treated samples when compared to untreated ones. Lactic acid bacteria were found to be the main spoilage index. The rates of microbiological and organoleptic deterioration were estimated, and their temperature dependence was modeled by the Arrhenius equation. An increase of their shelf life of five to eight times was estimated, compared to untreated ones. A sensory survey on HP treated cooked ham showed that the consumers could not distinguish differences between control and processed samples immediately after processing. Obtained results were used along with appropriate tools relevant to cold chain management to demonstrate that HP treated products are less perishable compared to control ones, allowing for short exposure to temperature deviations during transportation and storage. This has a positive impact on the reduction of the frequency of spoiled products before consumption, acting as a useful tool for the meat product’s loss and waste reduction.

The resolution of short-exposure imaging through turbulence is studied with simulation for two phase tilt definitions, Z-tilt and G-tilt, which are applied to remove the instantaneous aperture averaged tilt in a short exposure. Applying the Z-tilt definition provides results that are consistent with Fried’s short-exposure theory. Applying the G-tilt definition produces narrower point spread functions that can deviate significantly from far-field theory.

Are perceptual chunks in memory central to the process of drawing? This study adopts a simple transcription drawing task in which patterns of dots are viewed and reproduced. Data from two experiments (Haladjian & Mathy, 2015) are re-analysed for evidence of chunking. Chunking was evident with long stimuli exposure time but not short (\(\le \)200 ms). With more opportunity to chunk, various temporal and spatial signals suggest the occurrence chunking, including: actions are temporally clustering into groups with sizes of typical chunks; pauses between actions are longer with long exposure than with short exposure; spatial locations of responses are sometimes clustered as simple geometric shapes; clusters of responses are more likely to occur at the start or end of trials.

Antifouling paints are applied to prevent the growth of marine biofouling. In Indonesia, that paint is widely used for ship which commonly used copper-based biocide. In fact, there is no or little comprehesive studies on antifouling paint in Indonesia compared to other tropical countries. In this study, the evaluation of the performance for antifouling paint was carried out where anticorrosion paint and bare steel were also studied as references. The measurement of corrosion rate on steel was conducted by weight loss method. The panels containing specimens were exposure up to 1-month for immersion in different depth of sea up to 3 meters. Seawater parameters consisting of temperature, pH, salinity, conductivity and dissolved oxygen were measured as well as coating properties. The results showed both surfaces of anticorrosion paint and steel specimens covered by biofouling, but not on antifouling paint. There also is not much different in antifouling paint properties before and after exposure in various depth of sea. The reduction of thickness for antifouling paint is apparently predominant to be affected by sea current. The magnitude of corrosion rate on bare steel is almost the same in different depth of sea which took place due to the effect of dissolved oxygen and biofouling. In the future, the comparison of the paints perfomance all local regions is necessary to be conducted in all local regions of the Indonesia.

The hypothesis was tested that differences in response to water-deficits between low osmotic potential (LOP) and high osmotic potential (HOP) maize (Zea mays L.) near-isolines were associated with differences in transpiration rate sensitivity to abscisic acid (ABA) and/or sulfate. In a series of four experiments, decreases in transpiration rate (DTR) of whole plants and fully expanded leaves were measured in response to treatments of 1.0 &micro, M ABA and 15 mM MgSO4 singly and in combination following long (2 day) and short (180 min) exposures. There was little evidence that intact plants grown on soil were responsive to the treatments. For hydroponically grown plants subjected to long exposure, there was similarly no response to treatments. Further, the short exposure of hydroponically grown plants to solely ABA or a combination of chemicals resulted in no sensitivity in DTR for either of the near-isolines. On the other hand, when these plants were fed sulfate, the transpiration was stimulated by about 20% for the LOP and 60% for the HOP. Detached leaves proved to be the most sensitive to treatment. Treatment with the two chemicals singly caused essentially equivalent DTR in the two near-isolines. However, treatment with ABA plus sulfate resulted in different DTR between the two near-isolines with values of 65% for the LOP and 16% for the HOP near-isoline. Overall, these results showed that the short exposure treatment of hydroponically grown plants or detached leaves supported the hypothesis of different transpiration rate sensitivities of the near-isolines in response to ABA and sulfate treatments.

Background Virtual reality (VR) exergaming has the potential to target sedentary behavior. Immersive environments can distract users from the physical exertion of exercise and can motivate them to continue exergaming. Despite the recent surge in VR popularity, numerous users still experience VR sickness from using head-mounted displays (HMDs). Apart from the commonly assessed self-reported symptoms, depth perception and cognition may also be affected. Considering the potential benefits of VR exergaming, it is crucial to identify the adverse effects limiting its potential and continued uptake. Objective This study aims to investigate the consequences of playing one of the most popular VR exergames for 10 and 50 min on aspects of vision, cognition, and self-reported VR sickness. Methods A total of 36 participants played an exergame, called Beat Saber, using an HMD. A repeated measures within-subject design was conducted to assess changes in vision, cognition, and well-being after short (10 min) and long (50 min) durations of VR exposure. We measured accommodation, convergence, decision speed, movement speed, and self-reported sickness at 3 test periods—before VR, immediately after VR, and 40 min after VR (late). Results Beat Saber was well tolerated, as there were no dropouts due to sickness. For most participants, any immediate aftereffects were short-lived and returned to baseline levels after 40 min of exiting VR. For both short and long exposures, there were changes in accommodation (F1,35=8.424; P=.006) and convergence (F1,35=7.826; P=.008); however, in the late test period, participants returned to baseline levels. Measures on cognition revealed no concern. The total simulator sickness questionnaire (SSQ) scores increased immediately after VR (F1,35=26.515; P Conclusions Irrespective of the duration of exposure, this study found no strong evidence for adverse symptoms 40 min after exiting VR; however, some individuals still reported high levels of VR sickness at this stage. We recommend that users commit to a waiting period after exiting VR to ensure that any aftereffects have deteriorated. Exergames in HMDs have the potential to encourage people to exercise but are understudied, and the aftereffects of exergaming need to be closely monitored to ensure that VR exergames can reach their full potential.