1. [Pharmacokinetics of fentanyl during sevoflurane based general anesthesia in children].
- Author
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Tsypin LE, Lazarev VV, Bryzzheva IA, Shchukin VV, Kochkin VS, Izotov BN, Lisovskaia SB, and Shtyn' NA
- Subjects
- Adolescent, Anesthetics, Intravenous administration & dosage, Anesthetics, Intravenous blood, Child, Child, Preschool, Drug Therapy, Combination, Fentanyl administration & dosage, Fentanyl blood, Hemodynamics drug effects, Humans, Infusions, Intravenous, Injections, Intravenous, Monitoring, Intraoperative, Sevoflurane, Treatment Outcome, Anesthesia, General methods, Anesthetics, Inhalation administration & dosage, Anesthetics, Intravenous pharmacokinetics, Fentanyl pharmacokinetics, Methyl Ethers administration & dosage
- Abstract
The research is based on the analysis of 50 cases of anesthesia during reconstructive surgeries in children. The anesthesia was based on inhalation of sevolflurane and injection of fentanyl by the bolus infusion scheme. During the different stages of anesthesia the opioid concentration in plasma was measured. Analysis of hemodynamic parameters showed no statistically significant differences in changes in performance, indicating the steady flow of anesthesia. Infusion of fentanyl provided a smooth, gradual decrease in its concentration in plasma, while analgesia remained adequate. The combination of sevoflurane in a concentration of 1.3 MAC and infusion of fentanyl to a total dose 6 mkg/kg/h was effective in provisioning stable anesthesia in the given category of patients with surgical pathology.
- Published
- 2011