33 results on '"Siliang Man"'
Search Results
2. Construction of an easy‐to‐use predictive model for ultrasound‐detected tophi to improve the detection of hidden tophi
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Wei Liu, Wen Guo, Kaiping Zhao, Qiang Zang, Husheng Wu, Siliang Man, Hongchao Li, Liang Zhang, and Hui Song
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clinical model ,gout ,nomogram ,tophi ,ultrasound ,Immunologic diseases. Allergy ,RC581-607 ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Abstract Background Musculoskeletal ultrasound is used in clinical practice to evaluate gout patients and is an effective imaging tool for the detection of tophi. The aim of this study was to analyze the factors associated with ultrasound‐detected tophi in gout patients and to construct a clinical model to predict its occurrence and improve the detection of hidden tophi. Methods Data of gout patients admitted to Beijing Jishuitan Hospital from January 2015 to December 2021 were collected. The complete and detailed information from gout cases with completed musculoskeletal ultrasound was included in the analysis. Univariate and multivariate analyses were used to identify independent factors associated with ultrasound‐detected tophi. A nomogram was used to visualize the clinical predictive models. Results Among 517 gout patients, rheumatologists found that 67 patients (13.0%) had subcutaneous tophi by visual observation, while musculoskeletal ultrasound revealed that 123 patients (23.8%) had ultrasound‐detected tophi with odds ratio [OR] (95% confidence intervals [CIs]) = 2.20 (1.81–2.67). Disease duration, upper limb joint flare (ULJF), persistent joint pain (PJP), uric acid, and homocysteine levels were independently associated with ultrasound‐detected tophi, and they had ORs (95% CIs) of 1.092 (1.050–1.136), 3.732 (2.312–6.025), 1.864 (1.086–3.200), 1.003 (1.001–1.004), and 1.015 (1.000–1.030), respectively. After balancing the complexity and accuracy of the model, Model 2 (incorporating disease duration, ULJF, PJP, and uric acid) was chosen to create a nomogram to predict the occurrence of ultrasound‐detected tophi. The nomogram had good discrimination (consistency index [C‐index] = 0.774) and excellent calibration, demonstrated by calibration curves. Conclusion Using easily available indicators, such as disease duration, the nature of the joint pain, and uric acid levels, we successfully developed an easy‐to‐use clinical model to improve the detection of hidden tophi.
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- 2023
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3. Predisposing factors for allogeneic blood transfusion in patients with ankylosing spondylitis undergoing primary unilateral total hip arthroplasty: a retrospective study
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Tao Bian, Liang Zhang, Siliang Man, Hongchao Li, Yong Dou, and Yixin Zhou
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Allogeneic blood transfusion ,Ankylosing spondylitis ,Hemoglobin ,Hip arthroplasty ,Tranexamic acid ,Orthopedic surgery ,RD701-811 ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Abstract Background The transfusion rate is relatively high in patients with ankylosing spondylitis (AS) undergoing total hip arthroplasty (THA). However, relevant studies focusing on the predisposing factors for transfusion with a large sample size are lacking. This study aimed to investigate the incidence of and risk factors for allogeneic blood transfusion in patients with AS undergoing primary unilateral THA. Methods This retrospective study included 331 patients with AS who underwent primary unilateral THA between 2011 and 2021. Relevant parameters were collected through a chart review. Multivariate logistic regression analysis was conducted to identify possible factors associated with perioperative allogeneic blood transfusion. Results A total of 113 (34.1%) patients received perioperative allogeneic blood transfusions. Factors related to receiving an allogeneic blood transfusion included prolonged operative duration (odds ratio [OR] per 10 min = 1.139, P = 0.047), increased estimated intraoperative blood loss (OR per 100 mL = 1.348, P
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- 2023
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4. Risk of infections of biological and targeted drugs in patients with spondyloarthritis: meta-analysis of randomized clinical trials
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Lidong Hu, Siliang Man, Xiaojian Ji, Yiwen Wang, Xingkang Liu, Jiaxin Zhang, Chuan Song, Jian Zhu, Feng Huang, and Lishao Guo
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Medicine - Abstract
Abstract. Background:. Concerns exist regarding the risk of infections in patients with spondyloarthritis (SpA) treated with biologics. We assessed the risk of infections of biological and targeted drugs in patients with SpA by performing a meta-analysis based on randomized controlled trials (RCTs). Methods:. A systematic literature search was conducted in PubMed, Embase, Web of Science, the Cochrane Library, and China Biology Medicine Disc for RCTs evaluating the risk of infections of biological therapy in patients with SpA from inception through August 9, 2021. We calculated a pooled Peto odds ratio (OR) for infections in biologics-treated patients vs. placebo patients. The risk of bias on the included RCTs was assessed by using the Cochrane Risk of Bias Tool. Results:. In total, 62 studies were included in this meta-analysis. Overall, the risk of infection (Peto OR: 1.16, 95% confidence interval [CI]: 1.07–1.26, P
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- 2022
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5. Risk of tuberculosis in patients with rheumatoid arthritis treated with biological and targeted drugs: meta-analysis of randomized clinical trials
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Xiaojian Ji, Lidong Hu, Yiwen Wang, Siliang Man, Xingkang Liu, Chuan Song, Jiaxin Zhang, Jian Zhu, Jianglin Zhang, Feng Huang, and Lishao Guo
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Medicine - Abstract
Abstract. Background:. Concerns exist regarding the potential development of tuberculosis in patients with rheumatoid arthritis (RA) treated with biological and targeted drugs. We assessed systematically whether biological therapy increased the risk of tuberculosis in patients with RA by meta-analysis of randomized controlled trials (RCTs). Methods:. A systematic literature search was conducted in PubMed, Embase, the Cochrane Library, and China Biology Medicine disc for RCTs evaluating biological therapy in patients with RA from inception through August 2021. Traditional meta-analysis and network meta-analysis were performed to compare the risk of tuberculosis for each biologics class in patients with RA. Peto odds ratio (Peto OR) and its 95% confidence interval (CI) were calculated as the primary effect measure. Results:. In total, 39 studies with 20,354 patients were included in this meta-analysis, and 82 patients developed tuberculosis. The risk of tuberculosis was increased in patients treated with biologics compared with non-biologics (Peto OR: 3.86, 95% CI: 2.36–6.32, P
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- 2022
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6. The correlation between volumetric bone mineral density and morphological parameters of the proximal femur and clinical outcomes in ankylosing spondylitis patients with hip involvement
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Xinfeng Wu, Liang Zhang, Tao Bian, Siliang Man, Hongchao Li, Wei Liu, and Yixin Zhou
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ankylosing spondylitis ,bone mineral density ,proximal femur ,quantitative computed tomography ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Abstract Background To measure volumetric bone mineral density (vBMD) with quantitative computed tomography (QCT) in the proximal femur of ankylosing spondylitis (AS) patients with hip involvement and analyze their correlations with radiographic and clinical parameters. Methods Sixty-five AS inpatients were enrolled in this study. The bone mineral density was measured by QCT and dual-energy x-ray absorptiometry (DXA), respectively. The morphological parameters of the proximal femur were measured on digital anteroposterior (AP) radiographs of the pelvis. The correlations between them were analyzed by SPSS software. Results The average trabecular vBMD measured at the femoral neck was 136.38 ± 25.58 mg/cm3. According to the BASRI-Hip score, group A consisted of 39 hips (0–2 score) and group B consisted of 26 hips (3–4 score). There were significant differences regarding trabecular CTXA equivalent T-score between group A and B at the femoral neck (p = 0.004); intertrochanteric region (p
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- 2022
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7. Protrusio acetabuli in ankylosing spondylitis patients with end-stage hip involvement
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Hongchao Li, Liang Zhang, Siliang Man, Tao Bian, Mingxue Chen, Hui Song, Yixin Zhou, and Lishao Guo
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Medicine - Published
- 2022
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8. Assessment of hip involvement in patients with ankylosing spondylitis: reliability and validity of the Hip Inflammation MRI Scoring System
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Siliang Man, Liang Zhang, Tao Bian, Hongchao Li, Zhuyi Ma, and Yixin Zhou
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Ankylosing spondylitis ,Hip ,Classification system ,Reliability ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Abstract Background This study aimed to test the reliability and validity of the Hip Inflammation MRI Scoring System (HIMRISS) in assessing hip involvement of AS patients with AS at different stages of the bath ankylosing spondylitis radiology index (BASRI-hip) scoring system. Methods Fifty-two outpatients with ankylosing spondylitis (AS) were included in this study. The subjects’ data includes demographics, clinical characteristics, disease activity score, and functional index. Based on the Harris hip scoring (HHS) of involved hip and BASRI-hip score, we devided these patients into no hip involvement group((HHS ≥ 80 and BASRI ≤ 1) (Group A), mild hip involvement subgroup (BASRI = 2 or BASRI ≤ 1 and HHS ≤ 79) (Group B), and moderate to advanced hip involvement subgroup (BASRI ≥ 3) (Group C). Data was analyzed statistically by SPSS software. Results In total of 44 patients (88 hips), group A consisted of 21 hips, group B consisted of 42 hips and group C consisted of 25 hips. The test–retest intraclass correlation coefficients (ICCs) in four raters were 0.955 ~ 0.977 and interrater ICC was 0.993. HIMRISS correlated moderately with the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) (r = 0.540, p
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- 2021
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9. Endoscopic vs. Microscopic Transsphenoidal Surgery for the Treatment of Pituitary Adenoma: A Meta-Analysis
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Jia Chen, Hongyan Liu, Siliang Man, Geng Liu, Quan Li, Qingyao Zuo, Lili Huo, Wei Li, and Wei Deng
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pituitary adenoma ,endoscopic ,meta-analysis ,microscopic ,transsphenoidal surgery ,Surgery ,RD1-811 - Abstract
PurposeCurrently, endoscopic transsphenoidal surgery (ETS) and microscopic transsphenoidal surgery (MTS) are commonly applied treatments for patients with pituitary adenomas. This meta-analysis was conducted to evaluate the efficacy and safety of ETS and MTS for these patients.MethodsA computer search of Pubmed, Embase, Cochrane library, Web of Science, and Google Scholar databases was conducted for studies investigating ETS and MTS for patients with pituitary adenomas. The deadline is March 01, 2021. RevMan5.1 software was used to complete this meta-analysis after literature screening, data extraction, and literature quality evaluation.ResultsA total of 37 studies including 5,591 patients were included. There was no significant difference in gross tumor removal (GTR) and hormone-excess secretion remission (HES remission) between two groups [RR = 1.10, 95% CI (0.99–1.22), P = 0.07; RR = 1.09, 95% CI (1.00–1.20), P = 0.05]. ETS was associated with lower incidence of diabetes insipidus (DI) [RR = 0.71, 95% CI (0.58–0.87), P = 0.0008], hypothyroidism [RR = 0.64, 95% CI (0.47–0.89), P = 0.007], and septal perforation [RR = 0.32, 95% CI (0.13–0.79), P = 0.01] than those with MTS.ConclusionThis meta-analysis indicated that ETS cannot significantly improve GTR and HES remission. However, ETS could reduce the incidence of DI, hypothyroidism, and septal perforation without increasing the rate of other complications.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/#myprospero, identifier: CRD42021241217.
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- 2022
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10. Risk of Malignancy and Tuberculosis of Biological and Targeted Drug in Patients With Spondyloarthritis: Systematic Review and Meta-analysis of Randomized Controlled Trials
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Siliang Man, Lidong Hu, Xiaojian Ji, Yiwen Wang, Yingpei Ma, Lei Wang, Jian Zhu, and Feng Huang
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spondyloarthritis ,biologic therapy ,malignancy ,tuberculosis ,systematic review and meta-analysis ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Objective: Concerns exist regarding the potential development of malignancy and tuberculosis in patients with spondyloarthritis (SpA) treated with biologics. We assessed the extent to which biologic therapy may increase the risk of malignancy and tuberculosis in patients with SpA by meta-analysis to derive estimates of sparse harmful events occurring in Randomized Controlled Trials (RCTs).Methods: A systematic literature search was conducted in PubMed, EMbase, Web of Science, the Cochrane Library, and China Biology Medicine disc for RCTs evaluating the risk of sparse harmful events of biologic therapy in patients with SpA from inception through August 9, 2021. We calculated a pooled Peto OR for malignancy and tuberculosis in biologics-treated patients vs. placebo patients. The risk of bias on the included RCTs was assessed by using Cochrane Risk of Bias tool.Results: In total, 63 studies were included in this meta-analysis, and 83 patients and 7 patients developed malignancy and tuberculosis, respectively. Overall, the risk of malignancy and tuberculosis was increased in SpA patients treated with biologics compared to placebo (malignancy: Peto OR: 2.49, 95%CI: 1.61–3.87, p < 0.001; tuberculosis: Peto OR: 5.98, 95%CI: 1.29–27.76, p = 0.022). Remarkably, compared to placebo, there was higher risk of malignancy for IL-17 inhibitors (Peto OR: 3.68, 95%CI: 1.20–11.30, p = 0.023) and small molecule targeted drugs (Peto OR: 3.08, 95%CI: 1.37–6.90, p = 0.043) in peripheral SpA, and for TNF receptor-Fc fusion protein in axial SpA (Peto OR: 7.18, 95%CI: 1.21–42.69, p = 0.030). Besides, the risk of tuberculosis was higher for anti-TNFα antibody in axial SpA (Peto OR: 6.17, 95%CI: 1.03–37.13, p = 0.046).Conclusion: This meta-analysis showed an elevated risk of malignancy in patients with peripheral SpA treated with biologics, especially for IL-17 inhibitors, and small molecule targeted drugs, a slightly increased risk of malignancy in TNF receptor-Fc fusion protein in axial SpA, and increased risk of tuberculosis in patients with axial SpA treated with anti-TNFα antibody. These findings need to be validated by studies with larger population and longer follow-up.
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- 2021
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11. Underweight and obesity are strong predictors of clinical outcomes in patients with ankylosing spondylitis: data from the Smart-phone SpondyloArthritis Management System
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Lidong Hu, Xiaojian Ji, Yiwen Wang, Siliang Man, Xingkang Liu, Lei Wang, Jian Zhu, Jidong Cheng, and Feng Huang
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Diseases of the musculoskeletal system ,RC925-935 - Abstract
Background: The aim of this study was to examine the impact of underweight, overweight and obesity on clinical outcomes and treatment responses to biologics in Chinese patients with ankylosing spondylitis (AS). Methods: Body mass index (BMI) was available in 1074 patients from the Smart-phone SpondyloArthritis Management System. Patients were categorized into four groups based on BMI: underweight, normal weight, overweight and obesity. Multivariable median regression analyses examined the effect of underweight and obesity on clinical outcomes and treatment response to biologics. Results: Among 1074 patients with AS, normal weight accounted for 49.1%, while underweight, overweight, and obesity for 8.1%, 30.1%, and 12.0%, respectively. Compared to patients with normal weight, patients with underweight, overweight and obesity had an increased disease activity, while patients with underweight and obesity had a significantly poor Bath Ankylosing Spondylitis Functional Index and Assessment of Spondyloarthritis International Society Health Index scores. For tumor necrosis factor (TNF)-α inhibitor users, BMI was found to be negatively correlated with changes in disease activity in the multivariate regression model (all p
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- 2021
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12. Effectiveness of Subcutaneous Tumor Necrosis Factor Inhibitors in Patients With Ankylosing Spondylitis: A Real-World Prospective Observational Cohort Study in China
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Xiaojian Ji, Yiwen Wang, Zhengyuan Hu, Yingpei Ma, Siliang Man, Kunpeng Li, Yanyan Wang, Jian Zhu, Jianglin Zhang, and Feng Huang
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tumor necrosis factor ,ankylosing spondylitis disease activity ,real-world study ,adalimumab ,biosimilar etanercept ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Objective: This prospective observational study investigated the efficacy of tumor necrosis factor inhibitors (TNFis) on disease activity, physical functionality, and mobility in patients with ankylosing spondylitis (AS) in a real-world setting.Methods: The Chinese Ankylosing Spondylitis Prospective Imaging Cohort (CASPIC) is an ongoing cohort study. Patients with AS were included to one of two groups: the TNFi user group included those who received TNFi at any time point; the non-TNFi user group included those who did not receive TNFi. Disease activity, physical functionality, and mobility were assessed by AS Disease Activity Scores (ASDAS), Bath AS Functional Index (BASFI), and Bath AS Metrology Index (BASMI), respectively.Results: A total of 804 patients with AS (241 TNFi users and 563 non-TNFi users) were recruited. For TNFi users, 83% received an etanercept biosimilar and 17.0% received adalimumab. Seventy-three TNFi users (30.3%) discontinued TNFis during the follow-up period; the mean duration of TNFi treatment was 6.9 ± 3.2 months. Reductions in ASDAS were significantly greater in TNFi users than in nonusers at 3, 6, and 12 months (differences in ASDAS reduction were 0.61, 0.56, and 0.46 units, respectively, all P < 0.05). Similarly, the improvement in BASFI was significantly greater in users than in nonusers at 3, 6, and 12 months (differences in BASFI improvement: 0.31, 0.75, and 0.74 units, respectively, all P < 0.05). BASMI increased in nonusers at 6 and 12 months (0.27, P = 0.47; 0.66, P < 0.001, respectively), but did not change in users (−0.16 and −0.13, respectively, both P > 0.05). At 12 months, changes in BASMI were significantly greater in nonusers than in users (−0.60, P = 0.47).Conclusion: TNFis are effective against disease activity and improve the physical functionality of patients with AS, even in those who taper or discontinue TNFis. Thus, TNFis may retard the progression of spinal mobility dysfunction in AS patients. TNF may maintain spinal mobility as indicated by the BASMI.
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- 2019
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13. Characteristic of Biochemical Markers of Bone Turnover in Female Patients with Osteitis Condensans Ilii
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Chenjing LIU, Hui SONG, Hongchao LI, Zhe GUO, Siliang MAN
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osteitis ,osteitis condensans ilii ,bone turnover ,tp1np ,β-ctx ,oc ,25- (oh) vd3 ,Medicine - Abstract
Background It is sometimes difficult to distinguish osteitis condensans ilii (OCI) from other diseases, and exploring biochemical markers of bone turnover may contribute to the differential diagnosis. Objective To evaluate the characteristic and significance of biochemical markers of bone turnover in patients with OCI. Methods Participants were retrospectively selected from Beijing Jishuitan Hospital from June 2013 to February 2022, including 61 female outpatients and inpatients with OCI {observation group: 15-50 years old〔mean age of (33.8±6.6) years〕, duration of OCI of two weeks to 15 years}, and 61 healthy female physical examinees{control group: 15-48 years old〔mean age of (35.6±7.6) years〕}. The clinical data and biochemical markers of bone turnover were compared between the two groups. The correlations of biochemical markers of bone turnover with OCI-related indices were analyzed. Results The serum albumin of the observation group was significantly lower than that of the control group〔 (45.4±2.9) g/L vs (46.5±2.8) g/L〕 (t=2.190, P
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- 2022
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14. Patient-reported adherence to physical exercises of patients with ankylosing spondylitis
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Sai Ma, Liang Zhang, Siliang Man, Tao Bian, Hongchao Li, Weiyi Li, Zhuyi Ma, and Da He
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Rheumatology ,Antirheumatic Agents ,Anti-Inflammatory Agents, Non-Steroidal ,Humans ,Patient Compliance ,Spondylitis, Ankylosing ,General Medicine ,Exercise - Abstract
Introduction Studies on adherence to exercise therapy of patients with ankylosing spondylitis (AS) are rare, and the criteria for adherence to exercise are inconsistent. This study aimed to quantify patient-reported adherence to exercise therapy of Chinese outpatients with AS and investigate the factors related to poor adherence. Methods The subjects’ sociodemographic, disease-related, radiographic, and laboratory parameters were collected. Patients’ adherence to exercise therapy was assessed using the Exercise Attitude Questionnaire (EAQ) with a 4-point Likert scale. All cases were grouped as good adherence and poor adherence using a cutoff score of 60, according to a previous study. Univariate analysis was conducted to assess the intergroup differences. Then, we built a multivariate logistic regression model to identify possible significant factors related to poor adherence to exercise therapy. Results A total of 185 outpatients completed the questionnaire. The mean EAQ score was 49.4 (IQR, 40.7–59.3) and 146 patients (78.9%) were considered to have poor adherence, and 39 patients (21.1%) were considered to have good adherence. The rates of current nonsteroidal anti-inflammatory drugs (NSAIDs), conventional synthetic disease-modifying antirheumatic drugs (csDMARDs), and tumor necrosis factor-α inhibitor (TNF-i) use were significantly higher in the poor adherence group (p=0.001, p=0.027, p=0.018, respectively). Our multivariate logistic regression model revealed that the only significant associated factor was current use of NSAIDs (OR=3.517; p=0.016; 95% CI, 1.259–9.827). Conclusions Outpatients with AS had an unacceptable level of adherence to exercise therapy, and current use of NSAIDs was a significantly associated factor. Key Points• Outpatients with AS had an unacceptable level of adherence to exercise therapy.• Current use of NSAIDs exerted a negative impact on patients’ adherence to exercise therapy.
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- 2022
15. Risk of infections of biological and targeted drugs in patients with spondyloarthritis: meta-analysis of randomized clinical trials
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Lidong, Hu, Siliang, Man, Xiaojian, Ji, Yiwen, Wang, Xingkang, Liu, Jiaxin, Zhang, Chuan, Song, Jian, Zhu, and Feng, Huang
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Biological Products ,Nasopharyngitis ,Tumor Necrosis Factor-alpha ,Interleukin-17 ,Spondylarthritis ,Candidiasis ,Humans ,Janus Kinase Inhibitors ,General Medicine ,Randomized Controlled Trials as Topic - Abstract
Concerns exist regarding the risk of infections in patients with spondyloarthritis (SpA) treated with biologics. We assessed the risk of infections of biological and targeted drugs in patients with SpA by performing a meta-analysis based on randomized controlled trials (RCTs).A systematic literature search was conducted in PubMed, Embase, Web of Science, the Cochrane Library, and China Biology Medicine Disc for RCTs evaluating the risk of infections of biological therapy in patients with SpA from inception through August 9, 2021. We calculated a pooled Peto odds ratio (OR) for infections in biologics-treated patients vs. placebo patients. The risk of bias on the included RCTs was assessed by using the Cochrane Risk of Bias Tool.In total, 62 studies were included in this meta-analysis. Overall, the risk of infection (Peto OR: 1.16, 95% confidence interval [CI]: 1.07-1.26, P 0.001), serious infection (Peto OR: 1.65, 95% CI: 1.26-2.17, P 0.001), upper respiratory tract infection (URTI) (Peto OR: 1.17, 95% CI: 1.04-1.32, P = 0.008), nasopharyngitis (Peto OR: 1.25, 95% CI: 1.10-1.42, P 0.001), and Candida infection (Peto OR: 2.64, 95% CI: 1.48-4.71, P = 0.001) were increased in SpA patients treated with biologics compared with placebo. Sensitivity analysis based on biologics classes was conducted, and results demonstrated that compared with placebo, there was a higher risk of infection for tumor necrosis factor (TNF)-a inhibitors (Peto OR: 1.38, 95% CI: 1.13-1.68, P = 0.001) and interleukin (IL)-17 inhibitors (Peto OR: 1.55, 95% CI: 1.08-2.22, P = 0.018) in axial SpA, and for Janus kinase inhibitors in peripheral SpA (Peto OR: 1.39, 95% CI: 1.14-1.69, P = 0.001); higher risk of serious infection for IL-17 inhibitors in peripheral SpA (Peto OR: 3.46, 95% CI: 1.26-9.55, P = 0.016) and axial SpA (Peto OR: 2.01, 95% CI: 1.38-2.91, P 0.001); higher risk of URTI for TNF-a inhibitors in axial SpA (Peto OR: 1.37, 95% CI: 1.05-1.78, P = 0.019), and for apremilast in peripheral SpA (Peto OR: 1.60, 95% CI: 1.08-2.36, P = 0.018); higher risk of nasopharyngitis for TNF-a inhibitors in axial SpA (Peto OR: 1.41, 95% CI: 1.05-1.90, P = 0.022) and peripheral SpA (Peto OR: 1.49, 95% CI: 1.09-2.05, P = 0.013), and for IL-17 inhibitors in axial SpA (Peto OR: 1.35, 95% CI: 1.01-1.82, P = 0.044); higher risk of herpes zoster for Janus kinase inhibitors in peripheral SpA (Peto OR: 2.18, 95% CI: 1.03-4.62, P = 0.043); higher risk of Candida infection for IL-17 inhibitors in peripheral SpA (Peto OR: 2.52, 95% CI: 1.31-4.84, P = 0.006).This meta-analysis shows that biological therapy in patients with SpA may increase the risk of infections, including serious infections, URTI, nasopharyngitis, and Candida infection, which should be paid attention to in our clinical practice.
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- 2021
16. Assessment of hip involvement in patients with ankylosing spondylitis: reliability and validity of the Hip Inflammation MRI Scoring System
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Yixin Zhou, Zhuyi Ma, Tao Bian, Hongchao Li, Liang Zhang, and Siliang Man
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medicine.medical_specialty ,Sports medicine ,Intraclass correlation ,Diseases of the musculoskeletal system ,Severity of Illness Index ,Rheumatology ,Internal medicine ,Epidemiology ,Humans ,Medicine ,Spondylitis, Ankylosing ,Orthopedics and Sports Medicine ,BASDAI ,Inflammation ,Ankylosing spondylitis ,Hip ,business.industry ,Research ,Reproducibility of Results ,medicine.disease ,Reliability ,Magnetic Resonance Imaging ,RC925-935 ,Orthopedic surgery ,business ,BASFI ,Classification system - Abstract
Background This study aimed to test the reliability and validity of the Hip Inflammation MRI Scoring System (HIMRISS) in assessing hip involvement of AS patients with AS at different stages of the bath ankylosing spondylitis radiology index (BASRI-hip) scoring system. Methods Fifty-two outpatients with ankylosing spondylitis (AS) were included in this study. The subjects’ data includes demographics, clinical characteristics, disease activity score, and functional index. Based on the Harris hip scoring (HHS) of involved hip and BASRI-hip score, we devided these patients into no hip involvement group((HHS ≥ 80 and BASRI ≤ 1) (Group A), mild hip involvement subgroup (BASRI = 2 or BASRI ≤ 1 and HHS ≤ 79) (Group B), and moderate to advanced hip involvement subgroup (BASRI ≥ 3) (Group C). Data was analyzed statistically by SPSS software. Results In total of 44 patients (88 hips), group A consisted of 21 hips, group B consisted of 42 hips and group C consisted of 25 hips. The test–retest intraclass correlation coefficients (ICCs) in four raters were 0.955 ~ 0.977 and interrater ICC was 0.993. HIMRISS correlated moderately with the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) (r = 0.540, p Conclusions HIMRISS applied to patients with AS demonstrated a satisfactory reliability, meaning it is a reliable quantitive assessment tool for evaluating early hip involvement in patients with AS.
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- 2021
17. Symptoms compatible with Rome IV functional bowel disorder in patients with ankylosing spondylitis
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Lei, Wang, Chuan, Song, Yiwen, Wang, Lidong, Hu, Xingkang, Liu, Jiaxin, Zhang, Xiaojian, Ji, Siliang, Man, Nana, Zhang, Gang, Li, Yunsheng, Yang, Lihua, Peng, Zhimin, Wei, and Feng, Huang
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Rheumatology - Abstract
Objectives To determine the frequency of symptoms meeting Rome IV functional bowel disorder (FBD) in patients with ankylosing spondylitis (AS), investigate factors associated with FBD symptoms, and assess whether having FBD symptoms might influence AS disease activity. Methods In this cross-sectional study, we enrolled 153 AS patients without known colonic ulcers and 56 sex- and age-matched controls to evaluate FBD (or its subtypes) symptoms. Disease characteristics were also evaluated in the AS group. Results Sixty (39.2%) of 153 AS patients had FBD symptoms, which were more prevalent than controls (23.2%). Besides, symptoms compatible with irritable bowel syndrome (IBS) and chronic diarrhoea were detected in 18 and 43 AS patients, respectively. For the AS group, multivariable logistic regression analyses showed that symptoms of FBD, IBS, and chronic diarrhoea were negatively associated with using non-steroidal anti-inflammatory drugs and positively associated with comorbid fibromyalgia, respectively. In exploration about the effects of FBD (or its subtypes) symptoms on AS disease activity by multivariable linear regression analyses, FBD symptoms and chronic diarrhoea had universal positive associations with assessments of AS disease characteristics, respectively. Conclusions Patients with AS had frequent symptoms compatible with FBD, IBS, and chronic diarrhoea, proportions of which were lower in those with non-steroidal anti-inflammatory drug use. The improvement of FBD symptoms and chronic diarrhoea might be conducive to the disease status of AS patients.
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- 2022
18. Characteristics Associated with the Occurrence and Development of Acute Anterior Uveitis, Inflammatory Bowel Disease, and Psoriasis in Patients with Ankylosing Spondylitis: Data from the Chinese Ankylosing Spondylitis Prospective Imaging Cohort
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Xiaojian Ji, Lei Wang, Siliang Man, Lidong Hu, Feng Huang, Yiwen Wang, Jian Zhu, and Yingpei Ma
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medicine.medical_specialty ,Ankylosing spondylitis ,business.industry ,Hazard ratio ,medicine.disease ,Comorbidity ,Inflammatory bowel disease ,Rheumatology ,Confidence interval ,Acute anterior uveitis ,Internal medicine ,Psoriasis ,Cohort ,Immunology and Allergy ,Medicine ,business ,Original Research - Abstract
Introduction This study aimed to determine the association between extra-articular manifestations (EAMs) and baseline characteristics of patients with ankylosing spondylitis (AS) and identify their potential risk factors in an observational cohort. Methods We analyzed the data of consecutive patients with AS obtained between April 2016 and May 2019 from the ongoing Chinese Ankylosing Spondylitis Prospective Imaging Cohort. Results Among the 1414 patients with AS, 23.1% had experienced EAMs at baseline. The prevalence rates of acute anterior uveitis (AAU), inflammatory bowel disease, and psoriasis among patients with AS were 16.7, 6.9, and 2.6%, respectively, and the prevalence of AAU increased significantly with the disease duration. Patients with comorbidity of AAU and psoriasis had Ankylosing Spondylitis Disease Activity Score (ASDAS) than patients without EAMs (2.16 ± 0.984 vs. 1.99 ± 0.956 [p = 0.025] and 2.36 ± 1.01 vs. 1.99 ± 0.96 [p = 0.025]). Among the 1087 patients with AS without EAMs at baseline, 98 developed EAMs during follow-up. Long disease duration (> 10 years) and high disease activity at baseline (ASDAS > 2.1) were associated with the risk of new-onset EAMs (hazard ratio [HR] [95% confidence interval, CI], 2.150 [1.229–3.762] and 2.896 [1.509–5.561], respectively) and new-onset AAU (HR [95% CI], 2.197 [1.325–3.642] and 3.717 [1.611–8.574], respectively). Conclusions In Chinese patients with AS, patients with comorbidity of AAU and psoriasis had higher disease activity scores than patients without EAMs. Furthermore, the risk of AAU or combined EAMs increases with the duration of AS and appears to be associated with higher cumulative exposure to inflammation. Supplementary Information The online version contains supplementary material available at 10.1007/s40744-021-00293-0.
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- 2021
19. Protrusio acetabuli in ankylosing spondylitis patients with end-stage hip involvement
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Yixin Zhou, Hongchao Li, Tao Bian, Ming-Xue Chen, Siliang Man, Hui Song, and Liang Zhang
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medicine.medical_specialty ,Ankylosing spondylitis ,business.industry ,Protrusio acetabuli ,Acetabulum ,General Medicine ,medicine.disease ,Surgery ,Humans ,Medicine ,Hip Joint ,Spondylitis, Ankylosing ,Hip Prosthesis ,Stage (cooking) ,business - Published
- 2021
20. Predisposing factors for allogeneic blood transfusion in patients with ankylosing spondylitis undergoing primary unilateral total hip arthroplasty: a retrospective study
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Tao Bian, Liang Zhang, Siliang Man, Hongchao Li, Yong Dou, and Yixin Zhou
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Orthopedics and Sports Medicine ,Surgery - Abstract
Background The transfusion rate is relatively high in patients with ankylosing spondylitis (AS) undergoing total hip arthroplasty (THA). However, relevant studies focusing on the predisposing factors for transfusion with a large sample size are lacking. This study aimed to investigate the incidence of and risk factors for allogeneic blood transfusion in patients with AS undergoing primary unilateral THA. Methods This retrospective study included 331 patients with AS who underwent primary unilateral THA between 2011 and 2021. Relevant parameters were collected through a chart review. Multivariate logistic regression analysis was conducted to identify possible factors associated with perioperative allogeneic blood transfusion. Results A total of 113 (34.1%) patients received perioperative allogeneic blood transfusions. Factors related to receiving an allogeneic blood transfusion included prolonged operative duration (odds ratio [OR] per 10 min = 1.139, P = 0.047), increased estimated intraoperative blood loss (OR per 100 mL = 1.348, P P = 0.024). A higher body mass index (BMI) (OR = 0.914, P = 0.012), perioperative tranexamic acid (TXA) use (OR = 0.166, P P = 0.004) decreased the risk of transfusion. Conclusions In patients with AS undergoing THA, prolonged operative duration, increased estimated intraoperative blood loss, and increased postoperative drainage volume were found to be risk factors for transfusion, whereas a higher BMI, perioperative TXA use, and a higher preoperative hemoglobin level were protective factors. These results may aid in developing a better perioperative management strategy, ultimately reducing the need for transfusion.
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- 2022
21. Clinical Efficacy of Acupuncture for the Treatment of Rheumatoid Arthritis: Meta-Analysis of Randomized Clinical Trials
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Hongchao Li, Siliang Man, Liang Zhang, Lidong Hu, and Hui Song
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Complementary and alternative medicine ,Article Subject - Abstract
Objective. Acupuncture has been used by rehabilitation specialists as an adjunctive treatment for the symptomatic treatment of rheumatoid arthritis (RA). This meta-analysis aims to evaluate the efficacy of acupuncture in treating patients with RA. Methods. A comprehensive search was conducted in CBM, CNKI, PubMed, CENTRAL, Web of Science, and Embase from their inception up to March 2022. All randomized controlled trials (RCTs) without the language restriction, concerning the patients with RA treated with acupuncture, were included. Two reviewers independently assessed the risk of bias with the Cochrane Risk of Bias Assessment tool. Weight mean difference (MD) and 95% CI were calculated, and data were pooled with random effects model. Results. A total of eleven RCTs involving 796 patients with RA met the established inclusion criteria. This systematic review indicated the efficacy of acupuncture as an adjunctive treatment for patients with RA. Invasive acupuncture could reduce significantly in pain (MD = -1.00, 95% CI: −1.96 to −0.05, P = 0.040 ), health assessment questionnaire (HAQ, MD = −0.20, 95% CI: −0.30 to −0.11, P < 0.001 ), physician global assessment (PhGA, MD = −0.98, 95% CI: −1.23 to −0.72, P < 0.001 ), tender joint count (TJC, MD = −1.24, 95% CI: −2.11 to −0.37, P = 0.005 ), C-reactive protein (CRP, MD = −1.81, 95% CI: −3.32 to −0.29, P = 0.019 ), and erythrocyte sedimentation rate (ESR, MD = −3.03, 95% CI: −5.80 to −0.26, P = 0.032 ), while compared to control group. Laser acupuncture could reduce HAQ (MD = −0.15, 95% CI: −0.28 to −0.01, P = 0.034 ), the RA quality of life questionnaire (RAQoL, MD = −2.32, 95% CI: −4.40 to −0.25, P = 0.028 ), CRP (MD = −35.24, 95% CI: −36.49 to −33.99, P < 0.001 ), and interleukin-6 (IL-6, MD = −29.63, 95% CI: −49.34 to −9.92, P = 0.003 ), while compared to control group. No adverse events associated with acupuncture were reported. Conclusion. Available evidence suggests that acupuncture is beneficial for relieving pain and ameliorating quality of life and health index in patients with RA; thereby, it should be available as an adjunctive nonpharmacological treatment in rehabilitation programmes.
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- 2022
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22. Improvement of Disease Management and Cost Effectiveness in Chinese Patients with Ankylosing Spondylitis Using a Smart-Phone Management System: A Prospective Cohort Study
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Siliang Man, Zhengyuan Hu, Kunpeng Li, Jinshui Yang, Jian Zhu, Jianglin Zhang, Yingpei Ma, Yiwen Wang, Ying Zhang, Feng Huang, and Xiaojian Ji
- Subjects
Adult ,Male ,China ,medicine.medical_specialty ,Article Subject ,Cost effectiveness ,Cost-Benefit Analysis ,lcsh:Medicine ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,0302 clinical medicine ,Quality of life ,Psoriasis ,Internal medicine ,medicine ,Humans ,Spondylitis, Ankylosing ,030212 general & internal medicine ,Disease management (health) ,Prospective cohort study ,Spondylitis ,030203 arthritis & rheumatology ,Ankylosing spondylitis ,General Immunology and Microbiology ,business.industry ,lcsh:R ,Disease Management ,General Medicine ,Middle Aged ,Inflammatory Bowel Diseases ,medicine.disease ,Uveitis, Anterior ,Antirheumatic Agents ,Cohort ,Female ,Smartphone ,business ,Research Article - Abstract
Objectives. Ankylosing spondylitis (AS) is a chronic disease that decreases mobility, function, and quality of life. This study introduced the “Smart-phone SpondyloArthritis Management System” (SpAMS), an interactive mobile health (mHealth) tool designed for AS/spondyloarthritis (SpA) disease management and used SpAMS data to evaluate clinical characteristics of Chinese patients with AS. Methods. SpAMS integrates patient’s and physician’s portals in a smart phone application. The Chinese Ankylosing Spondylitis Prospective Imaging Cohort was launched using SpAMS in April 2016. Patient self-assessments were completed online at baseline and at every subsequent clinic visit. Physician-reported assessments and treatments were recorded by rheumatologists during each visit. Results. In total, 1201 patients with AS [mean (SD) age, 30.6 (8.7) years; male, 82.6%] were recruited. Mean (SD) disease duration was 8.4 (6.1) years. Past or current symptoms of acute anterior uveitis (AAU), psoriasis, and inflammatory bowel disease (IBD) were observed in 21.0%, 3.7%, and 9.4% of patients, respectively. AAU and IBD occurred significantly more in patients with symptom duration > 10 years. The most commonly used medications at baseline were nonsteroidal anti-inflammatory drugs (98.2%). Patients using tumour necrosis factor inhibitors accounted for 20.8%, and 66.4% of patients used conventional synthetic disease-modifying antirheumatic drugs. At baseline, 57.2% of patients had inactive disease (ID)/low disease activity (LDA); this rate significantly improved to 79.2% after a mean follow-up of 13.3 (5.9) months. Compared with relapsed patients, new achievers of ID/LDA underwent more online patient assessments (P < .001). Problems solved in SpAMS caused 29.1% of clinic visits to a tertiary hospital unnecessary. SpAMS saved an average of 5.3 hours and 327.4 RMB per person on traffic expenses; these expenses equalled 16% of the Chinese monthly disposable personal income. Conclusions. SpAMS is a time- and cost-saving disease management tool that can help patients with AS perform self-management and provide valuable data to clinicians.
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- 2019
23. Simple metabolic markers associated with tophaceous gout
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Siming Gao, Hongchao Li, Siliang Man, Wei Liu, and Hui Song
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medicine.medical_specialty ,Gout ,business.industry ,Incidence (epidemiology) ,Tophus ,General Medicine ,Hyperuricemia ,medicine.disease ,Gastroenterology ,Rheumatology ,Uric Acid ,Internal medicine ,medicine ,Humans ,Metabolic syndrome ,business ,TBIL ,Kidney disease ,Glomerular Filtration Rate - Abstract
INTRODUCTION The relationship between tophaceous gout and metabolic markers is not well understood. The aim of this study was to compare the correlations between different metabolic markers and tophi and evaluate their potential predictive values for tophus. METHOD We analysed the data of gout patients in Beijing Jishuitan Hospital from 2013 to 2020. Ten laboratory indicators (UA, eGFR, underexcretion, GLU, TRIG, HDL-C, ALT, TBIL, γ-GT and UPH) were included to evaluate the relationship between tophaceous gout and metabolic markers. RESULTS Tophi was present in 14.7% (119/808) of gout patients. UA, eGFR, ALT and γ-GT were independently related to the development of tophi; UA and γ-GT were positively correlated. The γ-GT/ALT ratio and UA/eGFR ratio showed a positive correlation with tophi, with (rho, P) of (0.305
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- 2021
24. Underweight and obesity are strong predictors of clinical outcomes in patients with ankylosing spondylitis: data from the Smart-phone SpondyloArthritis Management System
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Jian Zhu, Yiwen Wang, Siliang Man, Feng Huang, Lei Wang, Xiaojian Ji, Jidong Cheng, Xingkang Liu, and Lidong Hu
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0301 basic medicine ,medicine.medical_specialty ,obesity ,Diseases of the musculoskeletal system ,Overweight ,03 medical and health sciences ,0302 clinical medicine ,Rheumatology ,underweight ,Internal medicine ,Weight management ,ankylosing spondylitis ,medicine ,Orthopedics and Sports Medicine ,In patient ,Disease management (health) ,Original Research ,030203 arthritis & rheumatology ,Ankylosing spondylitis ,business.industry ,nutritional and metabolic diseases ,treatment response ,medicine.disease ,Obesity ,030104 developmental biology ,RC925-935 ,Underweight ,medicine.symptom ,business ,Body mass index ,disease activity - Abstract
Background: The aim of this study was to examine the impact of underweight, overweight and obesity on clinical outcomes and treatment responses to biologics in Chinese patients with ankylosing spondylitis (AS). Methods: Body mass index (BMI) was available in 1074 patients from the Smart-phone SpondyloArthritis Management System. Patients were categorized into four groups based on BMI: underweight, normal weight, overweight and obesity. Multivariable median regression analyses examined the effect of underweight and obesity on clinical outcomes and treatment response to biologics. Results: Among 1074 patients with AS, normal weight accounted for 49.1%, while underweight, overweight, and obesity for 8.1%, 30.1%, and 12.0%, respectively. Compared to patients with normal weight, patients with underweight, overweight and obesity had an increased disease activity, while patients with underweight and obesity had a significantly poor Bath Ankylosing Spondylitis Functional Index and Assessment of Spondyloarthritis International Society Health Index scores. For tumor necrosis factor (TNF)-α inhibitor users, BMI was found to be negatively correlated with changes in disease activity in the multivariate regression model (all p Conclusions: Both underweight and obesity except for overweight were associated independently with worse disease activity, physical function and health status. Overweight and obesity might impact on treatment responses to biologics in patients with AS. This argues that weight management, to maintain it at a normal level, should be one of the disease management strategies in patients with AS.
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- 2021
25. Effects of types and degrees of ankylosing spondylitis hip structural damages on post-total hip arthroplasty outcome measurements
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Siliang Man, Yixin Zhou, Hui Song, Liang Zhang, Feng Huang, Zhengyuan Hu, Yanwei Lv, and Xiaojian Ji
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Male ,total hip arthroplasty ,hip ,Intraclass correlation ,medicine.medical_treatment ,Arthroplasty, Replacement, Hip ,Walking ,Severity of Illness Index ,Osteoarthritis, Hip ,Weight-Bearing ,0302 clinical medicine ,Outcome Assessment, Health Care ,structural damage ,030212 general & internal medicine ,Range of Motion, Articular ,joint radiographic score ,Femur Head ,General Medicine ,Middle Aged ,medicine.anatomical_structure ,Treatment Outcome ,030220 oncology & carcinogenesis ,ComputingMethodologies_DOCUMENTANDTEXTPROCESSING ,Female ,Range of motion ,Research Article ,musculoskeletal diseases ,medicine.medical_specialty ,China ,Observational Study ,03 medical and health sciences ,Femoral head ,ankylosing spondylitis ,medicine ,Humans ,Spondylitis, Ankylosing ,Spondylitis ,Retrospective Studies ,Hip surgery ,business.industry ,Acetabulum ,Odds ratio ,Recovery of Function ,medicine.disease ,Arthroplasty ,Confidence interval ,Surgery ,Radiography ,Hip Prosthesis ,business - Abstract
Supplemental Digital Content is available in the text, To determine the effects of ankylosing spondylitis (AS)-associated hip damages on the outcome measurements after total hip arthroplasty (THA). The medical records of 122 patients with AS (181 hips) who underwent THA were retrospectively reviewed. The mean follow-up was 43.9 (32–129) months. The types and degrees of hip damages were evaluated by preoperative hip X-rays. The patients were grouped according to the satisfaction degree after the operation. Univariable and multivariable statistical analyses were conducted. The intraclass correlation coefficients for the assessment between the 2 reviewers in the study were 0.86 to 0.97. Cox regression showed that femoral head erosion severity had an effect on the recovery time of independent walking without crutches postoperatively (odds ratio = 1.467, 95% confidence interval: 1.050–2.409, P = .025). The mean time to recover independent walking in the severe femoral head erosion group was 7.3 ± 0.9 weeks, which was 4.6 ± 0.4 weeks longer than in the non-severe femoral head erosion group, as confirmed by the log-rank (Mantel–Cox) test (Chi-squared = 11.684, P = .001). The multivariable analysis showed that higher acetabular sclerosis scores correlated with lower postoperative dissatisfaction risk (odds ratio = 0.322, 95% confidence interval: 0.136–0.764). The multiple linear regression analysis showed that postoperative range of motion (ROM) improvement was affected by preoperative ROM of the hip, space narrowing degree, and ceramic-ceramic material for the weight-bearing surface (F = 179.81, P
- Published
- 2020
26. Tai Chi exercise can ameliorate physical and mental health of patients with knee osteoarthritis: systematic review and meta-analysis
- Author
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Feng Huang, Xingkang Liu, Siliang Man, Lidong Hu, Xiaojian Ji, Zhengyuan Hu, Jidong Cheng, Yingpei Ma, and Yiwen Wang
- Subjects
030203 arthritis & rheumatology ,medicine.medical_specialty ,business.industry ,Rehabilitation ,Physical Therapy, Sports Therapy and Rehabilitation ,Osteoarthritis ,Osteoarthritis, Knee ,medicine.disease ,Mental health ,03 medical and health sciences ,0302 clinical medicine ,Mental Health ,Meta-analysis ,Physical therapy ,medicine ,Humans ,Tai Ji ,business ,Exercise ,030217 neurology & neurosurgery ,Therapeutic strategy - Abstract
Objective: To systematically review the effects of Tai Chi exercise as a nonpharmacological therapeutic strategy on the physical and mental health in individuals with knee osteoarthritis. Data sources: A systematic literature retrieval has been conducted in PubMed, Web of Science, EMbase, CENTRAL, OVID, CINAHL, Physiotherapy Evidence Database, Chinese Biomedical Database and China National Knowledge Infrastructure up to June 2020 to identify the relevant randomised controlled trials (RCTs). Methods: Two authors assessed independently the risk of bias using the Cochrane Collaboration’s tool. Standardised mean difference (SMD) and 95% CI were calculated and data were combined using the fixed or random-effect model. The strength of evidence was rated with Grading of Recommendations Assessment, Development and Evaluation (GRADE) system. Results: A total of 16 RCTs involving 986 patients with knee osteoarthritis met the established inclusion criteria. The strength of evidence for the main outcomes was low or moderate. The systematic review illustrated the efficacy of Tai Chi exercise in treating and managing knee osteoarthritis. Patients’ outcomes practising Tai Chi exercise were improved significantly, including pain (SMD = ‒0.69, 95%CI: ‒0.95 to ‒0.44, P < 0.001), stiffness (SMD = ‒0.59, 95%CI: ‒0.91 to ‒0.27, P < 0.001), physical function (SMD = ‒0.92, 95%CI: –1.16 to ‒0.69, P < 0.001), dynamic balance (SMD = 0.69, 95%CI: 0.38 to 0.99, P < 0.001), physiological and psychological health (SF-36 PCS: SMD = 0.48, 95%CI: 0.28 to 0.68, P < 0.001; SF-36 MCS: SMD = 0.26, 95%CI: 0.06 to 0.45, P = 0.01). No adverse events associated with Tai Chi exercise were reported. Conclusion: Tai Chi exercise was beneficial for ameliorating physical and mental health of patients with knee osteoarthritis and should be available as an alternative non-pharmacological therapy in rehabilitation programmes.
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- 2020
27. Factors Associated with Radiological Hip Joint Involvement in Patients with Ankylosing Spondylitis
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Wei Liu, Hui Song, Peng Dong, Hongchao Li, and Siliang Man
- Subjects
musculoskeletal diseases ,medicine.medical_specialty ,Ankylosing spondylitis ,Joint involvement ,business.industry ,Internal medicine ,Radiological weapon ,medicine ,In patient ,medicine.disease ,business - Abstract
Background: The associated factors for hip involvement in patients with ankylosing spondylitis (AS) are poorly known. This study was to analyze the clinical data of patients with AS and to explore the potential associated factors of AS-related radiological hip joint.Methods: This was a cross-sectional study of patients diagnosed with AS and treated at the Beijing Jishuitan Hospital between 01/2013 and 12/2019. A BASRI-hip score ≥ 2 was defined as radiological hip joint involvement. Univariable and multivariable logistic regression analyses were performed to analyze the factors associated with radiological hip joint involvement.Results: A total of 350 AS patients were included. Patients with radiological hip joint involvement (BASRI-hip ≥2) accounted for 50.6% (177/350). The proportion of men was 83.7% (293/350). The mean age was 35.0±12.7 years old. The mean duration of the disease was 10.8±8.6 years. The HLA-B27 positive rate was 90.9% (318/350). The multivariable analysis showed that the juvenile onset (OR=4.955, 95%CI: 2.464-9.961, PConclusion: AS with radiological hip joint involvement had worse body function and lower bone density. The associated factors with radiological hip joint involvement in AS patients included juvenile-onset, thin body size. The prognosis of patients with AS who received continuous NSAIDs drug treatment might be improved.
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- 2020
28. Add-On Effects of Conventional Synthetic Disease-Modifying Anti-Rheumatic Drugs in Ankylosing Spondylitis: Data from a Real-World Registered Study in China
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Jian Zhu, Jianglin Zhang, Xiaojian Ji, Yiwen Wang, Yingpei Ma, Feng Huang, Siliang Man, and Zhengyuan Hu
- Subjects
Drug ,Adult ,Male ,medicine.medical_specialty ,China ,media_common.quotation_subject ,Disease ,Blood Sedimentation ,Severity of Illness Index ,Sulfasalazine ,Clinical Research ,Internal medicine ,Surveys and Questionnaires ,medicine ,Humans ,Spondylitis, Ankylosing ,Registries ,media_common ,Ankylosing spondylitis ,medicine.diagnostic_test ,business.industry ,General Medicine ,Middle Aged ,medicine.disease ,Discontinuation ,Thalidomide ,C-Reactive Protein ,Treatment Outcome ,Erythrocyte sedimentation rate ,Antirheumatic Agents ,Disease Progression ,Observational study ,Female ,business ,Biomarkers ,medicine.drug - Abstract
BACKGROUND The aim of this study was to investigate the effects of conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) on patients with ankylosing spondylitis (AS) using real-world data, and to analyze patients' choices of csDMARDs and reasons for discontinuation. MATERIAL AND METHODS This observational study included 320 patients satisfying the modified New York criteria for AS. Patients were grouped according to medication: Group 1: 122 patients receiving non-steroidal anti-inflammatory drug (NSAID) monotherapy; Group 2: 198 patients receiving csDMARDs and NSAIDs. Patients were followed for 18 months at 6-month intervals. The change in AS Disease Activity Score and C-reactive protein (ASDAS-CRP) at each visit was the primary outcome. Secondary outcomes were based on validated disease activity questionnaires, clinical assessment, and acute-phase biomarkers (CRP and erythrocyte sedimentation rate [ESR]). Inter-group relationships were assessed across the 18-month follow-up period using generalized additive mixed models. RESULTS Sulfasalazine and thalidomide were the most commonly used csDMARDs, with cumulative use times of 8.9±4.1 months and 9.1±4.7 months, respectively. In Group 2, 56 patients discontinued or switched csDMARDs during the follow-up period, with lack of efficacy being the primary reason. The ASDAS-CRP was found to decrease significantly in both groups; however, improvements in many parameters (including ASDAS-CRP, disease activity questionnaires and ESR) were greater in Group 2. CONCLUSIONS Use of csDMARDs can improve disease activity in terms of ASDAS-CRP. The addition of csDMARDs may provide increased benefits compared with NSAID monotherapy, particularly in the reduction of AS disease activity, in the Chinese population.
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- 2020
29. Supplementary_materials – Supplemental material for Tai Chi exercise can ameliorate physical and mental health of patients with knee osteoarthritis: systematic review and meta-analysis
- Author
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Lidong Hu, Yiwen Wang, Xingkang Liu, Xiaojian Ji, Yingpei Ma, Siliang Man, Zhengyuan Hu, Jidong Cheng, and Huang, Feng
- Subjects
FOS: Clinical medicine ,food and beverages ,110604 Sports Medicine ,FOS: Health sciences ,110904 Neurology and Neuromuscular Diseases ,110314 Orthopaedics - Abstract
Supplemental material, Supplementary_materials for Tai Chi exercise can ameliorate physical and mental health of patients with knee osteoarthritis: systematic review and meta-analysis by Lidong Hu, Yiwen Wang, Xingkang Liu, Xiaojian Ji, Yingpei Ma, Siliang Man, Zhengyuan Hu, Jidong Cheng and Feng Huang in Clinical Rehabilitation
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- 2020
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30. From the lung to the knee joint: Toxicity evaluation of carbon black nanoparticles on macrophages and chondrocytes
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Siliang Man, Yunjian Zhang, Sijin Liu, Shunhao Wang, Anyi Guo, Yajun Liu, and Juan Ma
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Male ,musculoskeletal diseases ,0301 basic medicine ,Environmental Engineering ,Knee Joint ,Cell Survival ,Health, Toxicology and Mutagenesis ,02 engineering and technology ,Pharmacology ,Matrix metalloproteinase ,Systemic inflammation ,Cell Line ,03 medical and health sciences ,Chondrocytes ,Soot ,Administration, Inhalation ,medicine ,Animals ,Environmental Chemistry ,Lung ,Waste Management and Disposal ,Inflammation ,Inhalation exposure ,Mice, Inbred BALB C ,Metalloproteinase ,Chemistry ,Macrophages ,Synovial Membrane ,021001 nanoscience & nanotechnology ,Pollution ,030104 developmental biology ,medicine.anatomical_structure ,Toxicity ,Nanoparticles ,Matrix Metalloproteinase 3 ,Synovial membrane ,medicine.symptom ,Reactive Oxygen Species ,0210 nano-technology - Abstract
Carbon black (CB), a core elemental carbon component of airborne particles, has been used as a model material to study environmental safety and health impacts of airborne particles. Although potential adverse effects of CB have been reported, limited knowledge is available regarding CB-induced metabolic disorders and secondary effects distant from primary target organs, such as the effects on joints. The knee cavity is a relatively closed space along the peripheral circulation route with a slow rate of interchange of nutrition with blood. While epidemiologic studies have indicated that airborne particle exposure may affect the occurrence and severity of inflammatory knee diseases, no research has been performed to understand the potential hazardous direct/indirect interactions between particles and knee cells. Herein, we have scrutinized the toxicity of four commercial nano-sized CB samples in the lung and a distant site: knee joint. Our results indicated that CB triggered pulmonary and systemic inflammation upon inhalation exposure, and, more strikingly, CB also elicited injuries of the knee joint, as demonstrated by thickened synovial membrane, suggesting disordered cellular metabolism within the knee joint. Our data recognized the CB toxicity profiles to macrophages as characterized by pro-inflammatory reactions, and also defined an activated metabolic state of chondrocytes, as evidenced by metalloproteinase (MMP) induction. Of note, remarkable variations were also found for these changes induced by these four CB samples, due to their distinct physicochemical properties. Collectively, our results uncovered a significant toxicity of CB inhalation exposure to the knee joint, as reflected by metabolic activation of chondrocytes, and, more importantly, these findings unearthed CB-induced metabolic disorders and secondary effects owing to systemic pro-inflammatory conditions upon CB exposure, in addition to the likelihood of direct toxicity to knee cells.
- Published
- 2018
31. Analysis of Bone Strength and Bone Turnover Markers in Ankylosing Spondylitis with Radiological Hip Involvement.
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Wei Liu, Hui Song, Siliang Man, Hongchao Li, and Liang Zhang
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- 2021
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32. Improvement of Disease Management and Cost Effectiveness in Chinese Patients with Ankylosing Spondylitis Using a Smart-phone Management System: A Prospective Cohort Study (Preprint)
- Author
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Xiaojian Ji, Yiwen Wang, Yingpei Ma, Zhengyuan Hu, Siliang Man, Ying Zhang, Kunpeng Li, Jinshui Yang, Jian Zhu, Jianglin Zhang, Yiming Luo, and Feng Huang
- Abstract
BACKGROUND Ankylosing spondylitis (AS) is a chronic disease that mainly affects the axial skeleton, leading to decreased mobility, function, and quality of life. With the advent of mobile health (mHealth) technologies, it is now possible to create more economical, sustainable, and user-friendly communication and health monitoring systems to improve the effectiveness of patient care and to gather real-world clinical data for clinical research. OBJECTIVE To introduce “smart-phone Spondyloarthritis Management System” (SpAMS), an interactive mobile health (mHealth) tool, specifically designed for longitudinal disease management and prospective ankylosing spondylitis (AS)/spondyloarthritis (SpA) and to evaluate the clinical profile of Chinese (AS) patients. METHODS SpAMS integrates the patient’s portal and the physician’s portal in a cell phone application. By using SpAMS, Chinese Ankylosing Spondylitis Prospective Imaging Cohort (CASPIC) was launched from April 2016. All patients fulfilled the 1984 modified New York criteria. Patient self-assessments were completed online at baseline and at every subsequent clinic visit. Physician-reported assessments and treatment regimens were recorded by rheumatologists during each visit. RESULTS In total, 1201 AS patients [mean (SD) age, 30.6 (8.7) years; male, 82.6%] were recruited. The mean (SD) disease duration was 8.4 (6.1) years. A history or current symptoms suggestive of acute anterior uveitis (AAU), psoriasis, and inflammatory bowel disease (IBD) were observed in 21.0%, 3.7%, and 9.4% of the patients, respectively. AAU and IBD were found significantly more in patients with a symptom duration > 10 years (31.1%, 12.5%, respectively). At the baseline visit, the most commonly used medications were non-steroidal anti-inflammatory drugs (NSAIDs) (98.2%). Patients using tumor necrosis factor inhibitors (TNFi) accounted for 20.8% of enrolled patients. Additionally, 66.4% of patients used conventional synthetic disease-modifying anti-rheumatic drugs (DMARDs). At baseline, the percentage of patients with inactive disease (ID)/low disease activity (LDA) was 57.2%, and this value improved significantly to 79.2% after a mean follow-up of 13.3 (5.9) months. Compared with relapsed patients, new achievers of ID/LDA underwent more online patient assessments (P < .001). By solving problems in SpAMS, 29.1% of clinic visits were unnecessary and therefore time had been saved. At least an average of 5.3 hours and 327.4 RMB per person spent on traffic was saved through SpAMS. The saved traffic expenses were equal to 16% of the Chinese monthly disposable personal income. CONCLUSIONS SpAMS is a time- and cost-saving disease management tool, helping AS patients perform self-management and providing valuable data to clinicians. This is the first nationwide real-world study of AS patients in China who use mHealth technology, and our results contribute significantly to characterizing the clinical profiles of Chinese patients with AS.
- Published
- 2018
33. Add-On Effects of Conventional Synthetic Disease-Modifying Anti-Rheumatic Drugs in Ankylosing Spondylitis: Data from a Real-World Registered Study in China.
- Author
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Siliang Man, Xiaojian Ji, Yiwen Wang, Yingpei Ma, Zhengyuan Hu, Jian Zhu, Jianglin Zhang, and Feng Huang
- Published
- 2020
- Full Text
- View/download PDF
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