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1. Correlation Between Long-Term Acetylsalicylic Acid Use and Prostate Cancer Screening with PSA. Should We Reduce the PSA Cut-off for Patients in Chronic Therapy? A Multicenter Study

Author

Mantica G, Chierigo F, Cassim F, Ambrosini F, Tappero S, Malinaric R, Parodi S, Benelli A, Dotta F, Ennas M, Beverini M, Vaccaro C, Smelzo S, Guano G, Mariano F, Paola C, Granelli G, Varca V, Introini C, Dioguardi S, Simonato A, Gregori A, Gaboardi F, Terrone C, and Van der Merwe A

Subjects
prostate-specific antigen, aspirin, inflammation, prostate cancer, prostate biopsy., Diseases of the genitourinary system. Urology, RC870-923
Abstract

Guglielmo Mantica,1 Francesco Chierigo,1,2 Farzana Cassim,3 Francesca Ambrosini,1,2 Stefano Tappero,1,2 Rafaela Malinaric,1,2 Stefano Parodi,1,2 Andrea Benelli,4 Federico Dotta,4 Marco Ennas,4 Martina Beverini,1,2 Chiara Vaccaro,5 Salvatore Smelzo,6 Giovanni Guano,1,2 Federico Mariano,1,2 Calogero Paola,1,2 Giorgia Granelli,1,2 Virginia Varca,5 Carlo Introini,4 Salvatore Dioguardi,7 Alchiede Simonato,7 Andrea Gregori,8 Franco Gaboardi,6 Carlo Terrone,1,2 André Van der Merwe3 1IRCCS Ospedale Policlinico San Martino, U.O. Urologia, Genova, Italy; 2Department of Surgical and Diagnostic Integrated Sciences (DISC), University of Genova, Genova, Italy; 3Department of Urology, Tygerberg Academic Hospital, Stellenbosch University, Cape Town, South Africa; 4Department of Urology, Galliera Hospital, Genoa, Italy; 5Department of Urology, ASST Rhodense, G. Salvini Hospital, Milan, Italy; 6Department of Urology, San Raffaele Turro Hospital, Milan, Italy; 7Department of Surgical, Oncological, and Oral Sciences, Section of Urology, University of Palermo, Palermo, Italy; 8Urology Unit, Ospedale Sacco, Milan, ItalyCorrespondence: Guglielmo Mantica, IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi, 10, Genoa, 16132, Italy, Tel +390105552815, Email guglielmo.mantica@gmail.comPurpose: To evaluate the prostate cancer (PCa) detection rate in men with chronic use of Aspirin and to compare it with the detection rate of non-users.Patients and Methods: Prospectively maintained database regarding patients undergoing prostate biopsy over the last 10 years in five institutions. Patients were divided into two groups according to their exposure to Aspirin. We relied on multivariable linear and logistic regression models to test whether Aspirin administration was associated with lower PSA values at prostate biopsy, higher PCa diagnosis, and higher Gleason Grade Grouping (GGG) at biopsy.Results: Were identified 1059 patients, of whom 803 (76%) did not take Aspirin vs 256 (24%) were taking it. In multivariable log-linear regression analysis, Aspirin administration was associated with lower PSA levels (OR 0.83, 95% CI 0.71– 0.97, p = 0.01), after controlling for age, prostate volume, smoking history, associated inflammation at prostate biopsy, presence of PCa at biopsy, and GGG. In multivariable logistic regression analysis, Aspirin administration was not found to be a predictor of PCa at prostate biopsy (OR 1.40, 95% CI 0.82– 2.40, p = 0.21) after controlling for age, PSA, smoking history, prostate volume, findings at digital rectal examination and the number of biopsy cores. In patients with PCa at prostate biopsy (n = 516), Aspirin administration was found to predict higher GGG (OR 2.24, 95% CI 1.01– 4.87, p = 0.04).Conclusion: Aspirin administration was found to be a predictor of more aggressive GGG. These findings suggest that a lower PSA threshold should be considered in patients taking Aspirin, as, despite low PSA levels, they might harbour aggressive PCa.Keywords: prostate-specific antigen, aspirin, inflammation, prostate cancer, prostate biopsy

Published
2022

5. Correction: The infection post flexible UreteroreNoscopy (I-FUN) predictive model based on machine learning: a new clinical tool to assess the risk of sepsis post retrograde intrarenal surgery for kidney stone disease

Author

Castellani, Daniele, De Stefano, Virgilio, Brocca, Carlo, Mazzon, Giorgio, Celia, Antonio, Bosio, Andrea, Gozzo, Claudia, Alessandria, Eugenio, Cormio, Luigi, Ratnayake, Runeel, Fugini, Andrea Vismara, Morena, Tonino, Tanidir, Yiloren, Sener, Tarik Emre, Choong, Simon, Ferretti, Stefania, Pescuma, Andrea, Micali, Salvatore, Pavan, Nicola, Simonato, Alchiede, Miano, Roberto, Orecchia, Luca, Pirola, Giacomo Maria, Naselli, Angelo, Emiliani, Esteban, Hernandez‑Penalver, Pedro, Di Dio, Michele, Bisegna, Claudio, Campobasso, Davide, Serafin, Emanuele, Antonelli, Alessandro, Rubilotta, Emanuele, Ragoori, Deepak, Balloni, Emanuele, Paolanti, Marina, Gauhar, Vineet, and Galosi, Andrea Benedetto

Published
2024
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6. The infection post flexible UreteroreNoscopy (I-FUN) predictive model based on machine learning: a new clinical tool to assess the risk of sepsis post retrograde intrarenal surgery for kidney stone disease

Author

Castellani, Daniele, De Stefano, Virgilio, Brocca, Carlo, Mazzon, Giorgio, Celia, Antonio, Bosio, Andrea, Gozzo, Claudia, Alessandria, Eugenio, Cormio, Luigi, Ratnayake, Runeel, Vismara Fugini, Andrea, Morena, Tonino, Tanidir, Yiloren, Sener, Tarik Emre, Choong, Simon, Ferretti, Stefania, Pescuma, Andrea, Micali, Salvatore, Pavan, Nicola, Simonato, Alchiede, Miano, Roberto, Orecchia, Luca, Pirola, Giacomo Maria, Naselli, Angelo, Emiliani, Esteban, Hernandez-Peñalver, Pedro, Di Dio, Michele, Bisegna, Claudio, Campobasso, Davide, Serafin, Emanuele, Antonelli, Alessandro, Rubilotta, Emanuele, Ragoori, Deepak, Balloni, Emanuele, Paolanti, Marina, Gauhar, Vineet, and Galosi, Andrea Benedetto

Published
2024
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8. Exploring the role of calf circumference as a predisposing factor for intra-hospital delirium: investigating potential gender differences: revealing potential gender variances

Author

Ceolin, Chiara, Papa, Mario Virgilio, Simonato, Cristina, Cazzavillan, Sara, Vergadoro, Margherita, Trapella, Giulia Salerno, Sermasi, Riccardo, De Rui, Marina, Noale, Marianna, Zanforlini, Bruno Micael, Curreri, Chiara, Bertocco, Anna, Devita, Maria, Sergi, Giuseppe, and Coin, Alessandra

Published
2024
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12. Cancer cell stiffening via CoQ10 and UBIAD1 regulates ECM signaling and ferroptosis in breast cancer

Author

Giovanni Tosi, Alessandro Paoli, Gaia Zuccolotto, Emilia Turco, Manuela Simonato, Daniela Tosoni, Francesco Tucci, Pietro Lugato, Monica Giomo, Nicola Elvassore, Antonio Rosato, Paola Cogo, Salvatore Pece, and Massimo M. Santoro

Subjects
Science
Abstract

Abstract CoQ10 (Coenzyme Q10) is an essential fat-soluble metabolite that plays a key role in cellular metabolism. A less-known function of CoQ10 is whether it may act as a plasma membrane-stabilizing agent and whether this property can affect cancer development and progression. Here, we show that CoQ10 and its biosynthetic enzyme UBIAD1 play a critical role in plasmamembrane mechanical properties that are of interest for breast cancer (BC) progression and treatment. CoQ10 and UBIAD1 increase membrane fluidity leading to increased cell stiffness in BC. Furthermore, CoQ10 and UBIAD1 states impair ECM (extracellular matrix)-mediated oncogenic signaling and reduce ferroptosis resistance in BC settings. Analyses on human patients and mouse models reveal that UBIAD1 loss is associated with BC development and progression and UBIAD1 expression in BC limits CTCs (circulating tumor cells) survival and lung metastasis formation. Overall, this study reveals that CoQ10 and UBIAD1 can be further investigated to develop therapeutic interventions to treat BC patients with poor prognosis.

Published
2024
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13. Exploring the role of calf circumference as a predisposing factor for intra-hospital delirium: investigating potential gender differences: revealing potential gender variances

Author

Chiara Ceolin, Mario Virgilio Papa, Cristina Simonato, Sara Cazzavillan, Margherita Vergadoro, Giulia Salerno Trapella, Riccardo Sermasi, Marina De Rui, Marianna Noale, Bruno Micael Zanforlini, Chiara Curreri, Anna Bertocco, Maria Devita, Giuseppe Sergi, and Alessandra Coin

Subjects
Delirium, Older adults, Calf circumference, Sarcopenia, Nutritional status, Geriatrics, RC952-954.6
Abstract

Abstract Background Malnutrition and sarcopenia significantly increase the risk of intra-hospital delirium, particularly among older adults. Given the potential correlation between calf circumference (CC) and these conditions, CC emerges as a promising predisposing factor for delirium. This study aims to investigate the independent association between delirium and anthropometric parameters, focusing on evaluating CC’s predictive capacity for intra-hospital delirium risk. Additionally, it aims to compare CC’s predictive performance with the widely used Mini Nutritional Assessment (MNA), while also considering potential gender disparities. Methods This is a retrospective study which enrolled patients aged ≥ 65 years from September 2021 to March 2022 at the Padova Hospital (Italy). Physical characteristics, intra-hospital delirium incidence, and body composition were assessed. Sarcopenia was diagnosed using the 2019 European Consensus criteria. Results Among 207 subjects, delirium affected 19% of patients. CC showed a significant association with intra-hospital delirium among the analyzed anthropometric parameters. ROC curves indicated that CC’s predictive capacity for delirium onset was comparable to MNA (p = 0.98), particularly in women. In a multivariable logistic regression model, female gender and higher cognitive and CC scores emerged as protective factors against delirium onset, with each unit increase in CC associated with a 24% reduction in the odds of delirium. Conversely, sarcopenia did not significantly influence delirium onset. Conclusions CC shows promise as a predisposing factor for intra-hospital delirium, similar to MNA, albeit with significant gender differences. CC could serve as a valuable tool for assessing delirium risk among female patients. Further validation of these findings is necessary through larger-scale studies.

Published
2024
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14. Evaluation of Clinical Research on Novel Multiport Robotic Platforms for Urological Surgery According to the IDEAL Framework: A Systematic Review of the Literature

Author

Vincenzo Ficarra, Marta Rossanese, Gianluca Giannarini, Nicola Longo, Silvia Viganò, Domenico Russo, Gabriele Sorce, Alchiede Simonato, Riccardo Bartoletti, Alessandro Crestani, and Ettore Di Trapani

Subjects
New surgical robots, Hugo RAS system, Versius robot, KangDuo robot, Senhance robot, Avatera robot, Diseases of the genitourinary system. Urology, RC870-923, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Background and objective: Several novel multiport robotic systems have been developed and introduced in clinical practice after regulatory approval. The objective of this systematic review was to assess the evolution status of novel robotic platforms approved for clinical use in urological surgery according to the IDEAL framework. Methods: A systematic review was conducted using the Medline and Scopus databases according to the updated Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines (CRD42024503227). Comparative or noncomparative studies reporting on any urological procedures performed with novel robotic platforms (Hugo RAS; Versius, KangDuo, Senhance, REVO-I, Avatera, Hinotori, Dexter, or Toumai) were selected and included in the analysis. Key findings and limitations: Seventy-four eligible studies were included, of which 67 (90.5%) were noncomparative surgical series representing developmental or explorative studies according to the IDEAL criteria. Only one randomised controlled trial (comparing KangDuo vs da Vinci robot-assisted partial nephrectomy) was included. The trial showed comparable perioperative outcomes between the two robotic systems. Four studies assessed clinical outcomes for patients undergoing urological procedures using a REVO-I (1 study), Senhance (2 studies), or Hinotori (1 study) system in comparison to the same procedures performed using a da Vinci system. All studies revealed outcomes comparable to those with the da Vinci system. Limitations include the small sample size in all studies, and assessment of first-generation novel platforms versus the fourth-generation multiarm da Vinci system in most of the comparative studies. Conclusions and clinical implications: A few poor-quality studies have compared the use of novel robotic platforms to da Vinci systems in urological surgery and demonstrated comparable results. Most studies can be classified as developmental or explorative, representing the initial steps of clinical research. Large multicentre series are needed to understand whether these novel robots could offer advantages beyond cost reductions over the da Vinci systems. Patient summary: We reviewed research on new robotic systems for surgery in urology. Several studies have shown the feasibility and safety of these new robots during the most common procedures. Very few studies have assessed clinical outcomes with the new robots in comparison to the reference standard, which is a fourth-generation da Vinci robot. Large multicentre studies are needed to understand whether the new robots could offer advantages other than cost savings over the da Vinci robot.

Published
2024
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15. Clove essential oil decreases antemortem stress and acts as an antioxidant in Nile tilapia

Author

Daniela Kaizer Terto, Amanda Gobeti Barro, Evelyn Rangel dos Santos, Guilherme Agostinis Ferreira, Jéssica Gonçalves Vero, Natália Nami Ogawa, Vanessa Bezerra, Juliana Delatim Simonato Rocha, Rafael Humberto de Carvalho, and Ana Maria Bridi

Subjects
Animal welfare, glutathione, hypothermia, lipid oxidation, protein oxidation, cranial percussion, Veterinary medicine, SF600-1100
Abstract

This study investigated the effect of clove essential oil used prior to stunning by cranial percussion and hypothermia on Nile tilapia (Oreochromis niloticus) welfare and fillet quality. A total of 100 tilapias were divided into four groups in a 2 × 2 factorial design, exploring two stunning methods with and without clove essential oil. Behavioral responses, glucose, lactate, pH, water holding capacity, color parameters, lipid and protein oxidation, and oxidative stress were analyzed. The application of clove essential oil resulted in 100% numbing in swimming and stimulus response behaviors, and 96% in balance and eye vestibule reflex variables. Significant reductions in glucose (12.12 mg dL−1) for hypothermia group (p = 0.001) and lactate (3.36 mmol L−1) for cranial percussion (p = 0.004), 0.028 nmol lipid oxidation in hypothermia treatment (p = 0.009), and 0.134 nmol carbonyls/mg protein (p = 0.001) were observed. There was a reduction in luminosity (p = 0.010) and red intensity (p = 0.001) in the group of fish fillet that received cranial percussion, however, there was no difference in the group stunned by hypothermia. Clove essential oil demonstrates effectiveness in pre-slaughter stress mitigation, influencing the antioxidant system positively. Its usage in pre-slaughter protocols could contribute to improved fillet quality, presenting a promising alternative for enhancing tilapia welfare during slaughter.

Published
2024
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16. Application for Mobile Devices to Measure Daily Protein Intake in the Elderly: PROT + First Results

Author

Silva, F. C. D., Martins, A. P. S., F.C.D.Silva, F. C. D., Simonato, L. E., Magalhães, D. S. F., Magjarević, Ratko, Series Editor, Ładyżyński, Piotr, Associate Editor, Ibrahim, Fatimah, Associate Editor, Lackovic, Igor, Associate Editor, Rock, Emilio Sacristan, Associate Editor, Marques, Jefferson Luiz Brum, editor, Rodrigues, Cesar Ramos, editor, Suzuki, Daniela Ota Hisayasu, editor, Marino Neto, José, editor, and García Ojeda, Renato, editor

Published
2024
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17. Prostate Cancer Detection: Performance of Radiomics Analysis in Multiparametric MRI

Author

Ali, Muhammad, Benfante, Viviana, Cutaia, Giuseppe, Salvaggio, Leonardo, Rubino, Sara, Portoghese, Marzia, Ferraro, Marcella, Corso, Rosario, Piraino, Giovanni, Ingrassia, Tommaso, Tulone, Gabriele, Pavan, Nicola, Di Raimondo, Domenico, Tuttolomondo, Antonino, Simonato, Alchiede, Salvaggio, Giuseppe, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Foresti, Gian Luca, editor, Fusiello, Andrea, editor, and Hancock, Edwin, editor

Published
2024
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18. Grading and Staging of Bladder Tumors Using Radiomics Analysis in Magnetic Resonance Imaging

Author

Benfante, Viviana, Salvaggio, Giuseppe, Ali, Muhammad, Cutaia, Giuseppe, Salvaggio, Leonardo, Salerno, Sergio, Busè, Gabriele, Tulone, Gabriele, Pavan, Nicola, Di Raimondo, Domenico, Tuttolomondo, Antonino, Simonato, Alchiede, Comelli, Albert, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Foresti, Gian Luca, editor, Fusiello, Andrea, editor, and Hancock, Edwin, editor

Published
2024
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21. Revised Tolmachev-Morel-Anderson pseudopotential for layered conventional superconductors with nonlocal Coulomb interaction

Author

Simonato, M., Katsnelson, M. I., and Rösner, M.

Subjects
Condensed Matter - Superconductivity, Condensed Matter - Strongly Correlated Electrons
Abstract

We study the effects of static nonlocal Coulomb interactions in layered conventional superconductors and show that they generically suppress superconductivity and reduce the critical temperature. Although the nonlocal Coulomb interaction leads to a significant structure in the superconducting gap function, we find that most properties can be effectively described by means of an appropriately revised local Coulomb pseudopotential $\tilde{\mu}_C^*$, which is larger than the commonly adopted retarded Tolmachev-Morel-Anderson pseudopotential $\mu^*_C$. To understand this, we analyze the Bethe-Salpeter equation describing the screening of Coulomb interaction in the superconducting state and obtain an expression for $\tilde{\mu}_C^*$, which is valid in the presence of nonlocal Coulomb interactions. This analysis also reveals how the structure of the nonlocal Coulomb interaction weakens the screening effects from high-energy pair fluctuations and therefore yields larger values of the pseudopotential. Our findings are especially important for layered conventional superconductors with small Fermi energies and can be easily taken into account ab initio studies., Comment: 9 pages, 7 figures

Published
2022

22. Prostate Cancer Detection: Performance of Radiomics Analysis in Multiparametric MRI

Author

Ali, Muhammad, primary, Benfante, Viviana, additional, Cutaia, Giuseppe, additional, Salvaggio, Leonardo, additional, Rubino, Sara, additional, Portoghese, Marzia, additional, Ferraro, Marcella, additional, Corso, Rosario, additional, Piraino, Giovanni, additional, Ingrassia, Tommaso, additional, Tulone, Gabriele, additional, Pavan, Nicola, additional, Di Raimondo, Domenico, additional, Tuttolomondo, Antonino, additional, Simonato, Alchiede, additional, and Salvaggio, Giuseppe, additional

Published
2024
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23. Grading and Staging of Bladder Tumors Using Radiomics Analysis in Magnetic Resonance Imaging

Author

Benfante, Viviana, primary, Salvaggio, Giuseppe, additional, Ali, Muhammad, additional, Cutaia, Giuseppe, additional, Salvaggio, Leonardo, additional, Salerno, Sergio, additional, Busè, Gabriele, additional, Tulone, Gabriele, additional, Pavan, Nicola, additional, Di Raimondo, Domenico, additional, Tuttolomondo, Antonino, additional, Simonato, Alchiede, additional, and Comelli, Albert, additional

Published
2024
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25. Orthostatic Ex-Vivo Lung Perfusion (EVLP): A Proof of Concept

Author

Massimo Boffini, Andrea Costamagna, Matteo Marro, Erika Simonato, Paola Cassoni, Luca Bertero, Vito Fanelli, Cristina Barbero, Luca Brazzi, and Mauro Rinaldi

Subjects
lung transplant, animal model, EVLP, organ preservation, perfusion, Specialties of internal medicine, RC581-951
Abstract

The key goal in lung donation remains the improvement of graft preservation with the ultimate objective of increasing the number and quality of lung transplants (LTx). Therefore, in recent years the field of graft preservation focused on improving outcomes related to solid organ regeneration and restoration. In this contest Ex-Vivo Lung Perfusion (EVLP) plays a crucial role with the purpose to increase the donor pool availability transforming marginal and/or declined donor lungs suitable for transplantation. Aim of this proof of concept is to test the safety, suitability and feasibility of a new tilting dome for EVLP designed considering the dorsal lung areas as the “Achilles’ heel” of the EVLP due to a more fluid accumulation than in the supine standard position.

Published
2024
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26. Guidance on mucositis assessment from the MASCC Mucositis Study Group and ISOO: an international Delphi studyResearch in context

Author

Ragda Abdalla-Aslan, Pierluigi Bonomo, Dorothy Keefe, Nicole Blijlevens, Katrina Cao, Yin Ting Cheung, Eduardo Rodrigues Fregnani, Robert Miller, Judith Raber-Durlacher, Joel Epstein, Ysabella Van Sebille, Elisa Kauark-Fontes, Abhishek Kandwal, Emma McCurdy-Franks, Joel Finkelstein, Victoria McCarvell, Yehuda Zadik, Giulia Ottaviani, Rui Amaral Mendes, Caroline Margina Speksnijder, Hannah Rose Wardill, Paolo Bossi, Alexa Laheij, Arghavan Tonkaboni, Jacqui Scott, Rania Abasaeed, Adel Kauzman, Adriana Do Socorro Lima Flato, Adwaita Gore, Anne-Marie Hardman, Agnes Horvath, Allan Hovan, Aisha Al-Jamaei, Aya koizumi, Alan Santos-Silva, Alessandra Majorana, Alexandre Giannini, Aléxia Teixeira, Muhammad Ali Shazib, Alison Melvin, Aluísio Miranda Filho, Amanda Gruza, Amber Brown-Dahl, Amit Harilall, Amr El Maghrabi, Ana Andabak Rogulj, Ana Raphaela Curvo, Ana Laura Soares, Andrea Stringer, Andréa Moreira, Andy Kurtzweil, Angelyn Salaberry, Anne Blazy, Anne Margrete Gussgard, Anne Marie Lynge Pedersen, Annette Freidank, Anura Ariyawardana, Adrian Ramseier, Jann Arends, Ariel Blanchard, Adriana Sesti Paz, Angela Thermann, Augusto Poropat, Azael Freites-Martinez, Abdul Rahman Al-Azri, Bente Brokstad Herlofson, Sitaraman BalajiSubramanian, Barbara Ballantyne, Kivanc Bektas-Kayhan, Bengt Hasséus, Benjamin Kaffenberger, Bernar Benites, Bernice Kwong, Beth Test, Fernando Chiantia, Bo Pettersson, Bomi Framroze, Božana Lončar Brzak, Brittany Dulmage, Sorin Buga, Caroline Spekssnijder, Carlton Brown, Antonio Carlos Moura de Melo, Ana Carolina Ribeiro, Caroline Silva, Caroline Fulop, Carryn Anderson, Catherine Flaitz, Cathy Massoud, Cesar Migliorati, Callie Gross, Chiara Gandini, Charles Loprinzi, Charlotte de Mooij, Catherine Hong, Ying Chu Choi, Maria Choy, Christine Boers-Doets, Leonard Schmeel, Cibele Nagano, Maria Coeli Franco, Courtney Subramaniam, Carolyn Patrick, Catherine Poh, Cristina Neuenschwander, Cesar Virgen, Dorothea Riesenbeck, Dale Weaver, Daniel Cohen Goldemberg, Daniel Sundaresan, Daniela Nunes, Danyel Perez, Daphine Travassos, David Yang, Daniela Ribeiro, Dean Kolbinson, Deborah Buick, Deborah Saunders, Juliane De Bortolli, Deepika Chugh, Denise Markstrom, Denise Travassos, Dianna Weikel, Dimitra Galiti, Dinusha Peiris, Fedja Djordjevic, Pankaj Singhai, Douglas Peterson, Douglas Fonseca, Doreen Pon, Iuliia Kovalenko, Aleksandra Polonskaia, Rogério Caldas, Kevin Saganski, Julia Néri, Dennis Abbott, Abhijna Vithal Yergolkar, Cristina Del Conte, Januaria Passos, Katia Uezu, Paula Silva, Steven Gilbert, Keng Yeoh, Kunal Jain, Madhup Rastogi, Satheeshkumar Poolakkad Sankaran, Deborah Manne, Evgeniya Shatokhina, Esther Adebayo-Olojo, Eszter Somogyi-Ganss, Eli Ehrenpreis, Wilber Bernaola-Paredes, Eduardo Fregnani, Elaci Cardoso, Elena Bardellini, Eleni Arvanitou, Elisa Kauark Fontes, Elise Bruning, Eloise Neumann, Elsa Madureira, Marcia Ramires, Erofili Papadopoulou, Etiene Munhoz, Fred Spijkervet, Fabiana Granzotto, Fabiana Martins, Fabio Alves, Farah Mougeot, Federica Aielli, Fernanda Pigatti, Fernanda Fonseca, Firoozeh Samim, Flavia Carvalho, Florence Cuadra Zelaya, Cesar Freytes, Gabriela da Silveira, Gabriela Torino, Gabriela Martins, Geisa Silva, Gemma Caro, Gemma Bryan, Georgette Radford, Ghanyah Al-Qadami, Giorgia Albini, Gisele Mainville, Georgios Gkardiakos, Gleidston Potter, Gulbin Hoeberechts, Gordon Howarth, Grace Bradley, Gunjan Verma, Gustavo dos Santos, Margaret Randles-Guzzardi, Hanlie Engelbrecht, Hannah Wardill, Heidi Hansen, Iquebal Hasan, Hironobu Hata, Helena Ullgren, Heliton Spindola Antunes, Heloísa Laís dos Santos, Howard Weld, Helen McInnes, Hans Peter Jungbluth, Hsiaofen Weng, Ian Hewson, Ingrid Santos, Jorge Illarramendi, Ines Semendric, Rol Menge, Inger Von Bultzingslowen, Maria da Gloria de Melo, Iona Leong, Isabella Fonseca, Isadora Kalif, James Carroll, Janet Coller, Johann Beck-Mannagetta, Joanne Bowen, Jose Meurer, Ricky McCullough, Jennifer Powers, Jesus Gomez, Jimma Lenjisa, jaya Vangara, Jasna Leko, Jane Fall-Dickson, Jean-Luc Mougeot, Joan Fox, Jolien Robijns, Jonn Wu, Patricio Palma, Jaya Amaram-Davila, Jim Siderov, Juliana Dantas, Juliana Jasper, Juliana Monteiro, Julia Bruno, julie pfeffer, Julija Jovanovic Ristivojevic, Juliana Brito, Jyothsna Kuriakose, Yuji Kabasawa, Kanan Dave, Karin Barczyszyn, Karol Sartori Lima, Kate Secombe, Kate White, Kate Cooper, Kouji Katsura, Karen Biggs, Katharine Ciarrocca, Kristopher Dennis, Ken Tomizuka, Kevin Hendler, Ikuko Komo, Kristina Skallsjö, Kristy Hodgins, Katia Rupel, Keiko Tanaka, Seema Kurup, Luiz Gueiros, Larissa Agatti, Laura Garzona-Navas, Letícia Guerra, Leila Portela, Leilani Iossi, Linda Elting, Lene Baad-Hansen, Leslie Reeder, Leticia Lang, Liciane Menezes, Liliana Braun, Liliane Grando, Mathew Lim, Lina Fernandez, Lucy McKeage, Luana Campos, Luciana Simonato, Luciana Muniz, Leah van Draanen, Mieko Mizutani, Tsai-Wei Huang, Mahfujul Riad, Mahnoor Nazar, Maíra Souza, Mariana Minamisako, Manoela Pereira, Carlos Mantelato, Márcio Diniz-Freitas, Marco Montezuma, Marco Andrade, Marcos Santos, Margherita Gobbo, Maria Caterina Fortuna, Mariana Vitor, Joana Marinho, Alina Markova, Marlyse Knuchel, Marta Carlesimo, Marta Neves, Andrew Mazar, Maria Cristina Gomez Amarilla, Mark Chambers, Melissa de Araujo, Alexandre Melo, Melody Cole, Mohamed Elsayed, Monica Fliedner, Martin Hauer-Jensen, Micaela Bouchacourt, Michael Brennan, Michael Thirlwell, Michio Nakamura, Midori Nakagaki, Camila Rossi, Mireille Kaprilian, Michael Kase, Michael Dougan, Monique Stokman, Ragnhild Monsen, Alisha Morgan, Jocelyn Harding, Maryam Taleghani, Marie-Therese Genot, Mukund Seshadri, Brian Muzyka, Nancy Batista, Nancy Gadd, Naoko Tanda, Narmin Nasr, Natália Garcia, Nathan Lee, Natalia Palmier, Norman Brito-Dellan, Nancy Corbitt, Neli Pieralisi, Verônica Serrano, Nicola Alessandro Iacovelli, Norma Lúcia Sampaio, Nour Karra, Niveditha Venkatesh, Noam Yarom, Renata Cristina Borin, Olivia Lemenchick, Ondina Mendes, Ourania Nicolatou-Galitis, Vasiliy Shchitka, Paula Reis, Paulo Sérgio Santos, Paz Fernandez-Ortega, Ira Parker, Raquel García, Peter Fritz, Edmund Peters, Pamela Gardner, Pierre Saint Girons, Priya Tiwari, Pravin Chaturvedi, Tais de Moraes, Priscila Andrade, Raj Nair, Rachel Gibson, Rachita Gururaj, Raghu Thota, Rajesh Lalla, Raquel Almeida Prado, Ravikiran Ongole, George Taybos, Regina Mackey, Renata Rego, Renata Camilotti, Renata Ferrari, Renato Junior, Rene-Jean Bensadoun, Richard Logan, Roberta Sales, Roberta Zanicotti, Roberta Tunes, Rodolfo Mauceri, Rosiene Feitoza, Kathryn Ruddy, Cynthia Rybczyk, Stephanie Trager, Sachiyo Mitsunaga, Sahani Gunathilake, Rajan Saini, Viola Salvestrini, Sandip Mukhopadhyay, Sandrina Angeloz, Pramod Sankar S, Luciana S Barbosa Barbosa, Elena Volkova, Sharon Elad, Sergio Cantoreggi, Sharon Gordon, Shelly Brown, Shu Yie Janine Tam, Sibelle Faleiro, Silmara da Silva, Silvia de Oliveira, Siri Beier Jensen, Ivana Skrinjar, Sophie Beaumont, Felipe Sperandio, Sandra Reese, Steven Roser, Sachiko Seo, Stephanie van Leeuwen, Stephen Sonis, Stephen Bernard, Stephen Rajan Samuel, Stuart Taylor, Suranjan Maitra, Susanne Skulski, Suzanne Carlisle, Sylvie Louise Avon, Tomoya Yokota, Takashi Yurikusa, Tabata Santos Polvora, Tabitha Kelock, Tauana Fernandes, Taylor Wain, Timothy Brown, Tetsuhito konishi, Thalyta Amanda Ferreira, Tomoko Kataoka, Thomas Kelly, Takehiko Mori, Tomoko Higuchi, Toshiaki Saeki, Nikolaos Tsoukalas, Typhaine Maupoint De Vandeul, Masatoshi Usubuchi, Vanessa Lacerda, Vanessa Tilly, Emmanuelle Vigarios, Alessandro Villa, Vinicius Torregrossa, Vinodh Kumar Selvaraj, Viviane Sarmento, Vivien Heng, Wagner Gomes-Silva, Petter Wilberg, Wanessa Miranda e Silva, Wan Nor I'zzah Wan Mohamad Zain, Wonse Park, Wim Tissing, Yoshihiko Soga, Bella Van Sebille, and Yuhei Matsuda

Subjects
Oral mucositis, Gastrointestinal mucositis, Mucositis assessment tools, Patient-reported outcome measures, Medicine (General), R5-920
Abstract

Summary: Background: Mucositis is a common and highly impactful side effect of conventional and emerging cancer therapy and thus the subject of intense investigation. Although common practice, mucositis assessment is heterogeneously adopted and poorly guided, impacting evidence synthesis and translation. The Multinational Association of Supportive Care in Cancer (MASCC) Mucositis Study Group (MSG) therefore aimed to establish expert recommendations for how existing mucositis assessment tools should be used, in clinical care and trials contexts, to improve the consistency of mucositis assessment. Methods: This study was conducted over two stages (January 2022–July 2023). The first phase involved a survey to MASCC-MSG members (January 2022–May 2022), capturing current practices, challenges and preferences. These then informed the second phase, in which a set of initial recommendations were prepared and refined using the Delphi method (February 2023–May 2023). Consensus was defined as agreement on a parameter by >80% of respondents. Findings: Seventy-two MASCC-MSG members completed the first phase of the study (37 females, 34 males, mainly oral care specialists). High variability was noted in the use of mucositis assessment tools, with a high reliance on clinician assessment compared to patient reported outcome measures (PROMs, 47% vs 3%, 37% used a combination). The World Health Organization (WHO) and Common Terminology Criteria for Adverse Events (CTCAE) scales were most commonly used to assess mucositis across multiple settings. Initial recommendations were reviewed by experienced MSG members and following two rounds of Delphi survey consensus was achieved in 91 of 100 recommendations. For example, in patients receiving chemotherapy, the recommended tool for clinician assessment in clinical practice is WHO for oral mucositis (89.5% consensus), and WHO or CTCAE for gastrointestinal mucositis (85.7% consensus). The recommended PROM in clinical trials is OMD/WQ for oral mucositis (93.3% consensus), and PRO-CTCAE for gastrointestinal mucositis (83.3% consensus). Interpretation: These new recommendations provide much needed guidance on mucositis assessment and may be applied in both clinical practice and research to streamline comparison and synthesis of global data sets, thus accelerating translation of new knowledge into clinical practice. Funding: No funding was received.

Published
2024
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31. Targeted Prostate Biopsy: How, When, and Why? A Systematic Review

Author

Giacomo Rebez, Maria Barbiero, Franco Alchiede Simonato, Francesco Claps, Salvatore Siracusano, Rosa Giaimo, Gabriele Tulone, Fabio Vianello, Alchiede Simonato, and Nicola Pavan

Subjects
targeted prostate biopsy, multiparametric MRI, transrectal ultrasound, diagnostic accuracy, prostate cancer detection, Medicine (General), R5-920
Abstract

Objective: Prostate cancer, the second most diagnosed cancer among men, requires precise diagnostic techniques to ensure effective treatment. This review explores the technological advancements, optimal application conditions, and benefits of targeted prostate biopsies facilitated by multiparametric magnetic resonance imaging (mpMRI). Methods: A systematic literature review was conducted to compare traditional 12-core systematic biopsies guided by transrectal ultrasound with targeted biopsy techniques using mpMRI. We searched electronic databases including PubMed, Scopus, and Web of Science from January 2015 to December 2024 using keywords such as “targeted prostate biopsy”, “fusion prostate biopsy”, “cognitive prostate biopsy”, “MRI-guided biopsy”, and “transrectal ultrasound prostate biopsy”. Studies comparing various biopsy methods were included, and data extraction focused on study characteristics, patient demographics, biopsy techniques, diagnostic outcomes, and complications. Conclusion: mpMRI-guided targeted biopsies enhance the detection of clinically significant prostate cancer while reducing unnecessary biopsies and the detection of insignificant cancers. These targeted approaches preserve or improve diagnostic accuracy and patient outcomes, minimizing the risks associated with overdiagnosis and overtreatment. By utilizing mpMRI, targeted biopsies allow for precise targeting of suspicious regions within the prostate, providing a cost-effective method that reduces the number of biopsies performed. This review highlights the importance of integrating advanced imaging techniques into prostate cancer diagnosis to improve patient outcomes and quality of life.

Published
2024
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35. Guidance on mucositis assessment from the MASCC Mucositis Study Group and ISOO: an international Delphi study

Author

Laheij, Alexa, Tonkaboni, Arghavan, Scott, Jacqui, Abasaeed, Rania, Kauzman, Adel, Flato, Adriana Do Socorro Lima, Gore, Adwaita, Hardman, Anne-Marie, Horvath, Agnes, Hovan, Allan, Al-Jamaei, Aisha, koizumi, Aya, Santos-Silva, Alan, Majorana, Alessandra, Giannini, Alexandre, Teixeira, Aléxia, Shazib, Muhammad Ali, Melvin, Alison, Filho, Aluísio Miranda, Gruza, Amanda, Brown-Dahl, Amber, Harilall, Amit, El Maghrabi, Amr, Rogulj, Ana Andabak, Curvo, Ana Raphaela, Soares, Ana Laura, Stringer, Andrea, Moreira, Andréa, Kurtzweil, Andy, Salaberry, Angelyn, Blazy, Anne, Gussgard, Anne Margrete, Lynge Pedersen, Anne Marie, Freidank, Annette, Ariyawardana, Anura, Ramseier, Adrian, Arends, Jann, Blanchard, Ariel, Paz, Adriana Sesti, Thermann, Angela, Poropat, Augusto, Freites-Martinez, Azael, Al-Azri, Abdul Rahman, Herlofson, Bente Brokstad, BalajiSubramanian, Sitaraman, Ballantyne, Barbara, Bektas-Kayhan, Kivanc, Hasséus, Bengt, Kaffenberger, Benjamin, Benites, Bernar, Kwong, Bernice, Test, Beth, Chiantia, Fernando, Pettersson, Bo, Framroze, Bomi, Bonomo, Pierluigi, Brzak, Božana Lončar, Dulmage, Brittany, Buga, Sorin, Spekssnijder, Caroline, Brown, Carlton, Melo, Antonio Carlos Moura de, Ribeiro, Ana Carolina, Silva, Caroline, Fulop, Caroline, Anderson, Carryn, Flaitz, Catherine, Massoud, Cathy, Migliorati, Cesar, Gross, Callie, Gandini, Chiara, Loprinzi, Charles, de Mooij, Charlotte, Hong, Catherine, Choi, Ying Chu, Choy, Maria, Boers-Doets, Christine, Schmeel, Leonard, Nagano, Cibele, Franco, Maria Coeli, Subramaniam, Courtney, Patrick, Carolyn, Poh, Catherine, Neuenschwander, Cristina, Virgen, Cesar, Riesenbeck, Dorothea, Weaver, Dale, Goldemberg, Daniel Cohen, Sundaresan, Daniel, Nunes, Daniela, Perez, Danyel, Travassos, Daphine, Yang, David, Ribeiro, Daniela, Kolbinson, Dean, Buick, Deborah, Saunders, Deborah, De Bortolli, Juliane, Chugh, Deepika, Markstrom, Denise, Travassos, Denise, Weikel, Dianna, Galiti, Dimitra, Peiris, Dinusha, Djordjevic, Fedja, Singhai, Pankaj, Keefe, Dorothy, Peterson, Douglas, Fonseca, Douglas, Pon, Doreen, Kovalenko, Iuliia, Polonskaia, Aleksandra, Caldas, Rogério, Saganski, Kevin, Néri, Julia, Abbott, Dennis, Yergolkar, Abhijna Vithal, Del Conte, Cristina, Passos, Januaria, Uezu, Katia, Silva, Paula, Gilbert, Steven, Yeoh, Keng, Jain, Kunal, Rastogi, Madhup, Sankaran, Satheeshkumar Poolakkad, Manne, Deborah, Shatokhina, Evgeniya, Adebayo-Olojo, Esther, Somogyi-Ganss, Eszter, Ehrenpreis, Eli, Bernaola-Paredes, Wilber, Fregnani, Eduardo, Cardoso, Elaci, Bardellini, Elena, Arvanitou, Eleni, Fontes, Elisa Kauark, Bruning, Elise, Neumann, Eloise, Madureira, Elsa, Ramires, Marcia, Papadopoulou, Erofili, Munhoz, Etiene, Spijkervet, Fred, Granzotto, Fabiana, Martins, Fabiana, Alves, Fabio, Mougeot, Farah, Aielli, Federica, Pigatti, Fernanda, Fonseca, Fernanda, Samim, Firoozeh, Carvalho, Flavia, Zelaya, Florence Cuadra, Freytes, Cesar, da Silveira, Gabriela, Torino, Gabriela, Martins, Gabriela, Silva, Geisa, Caro, Gemma, Bryan, Gemma, Radford, Georgette, Al-Qadami, Ghanyah, Albini, Giorgia, Mainville, Gisele, Gkardiakos, Georgios, Potter, Gleidston, Hoeberechts, Gulbin, Howarth, Gordon, Ottaviani, Giulia, Bradley, Grace, Verma, Gunjan, Santos, Gustavo dos, Randles-Guzzardi, Margaret, Engelbrecht, Hanlie, Wardill, Hannah, Hansen, Heidi, Hasan, Iquebal, Hata, Hironobu, Ullgren, Helena, Antunes, Heliton Spindola, Laís dos Santos, Heloísa, Weld, Howard, McInnes, Helen, Jungbluth, Hans Peter, Weng, Hsiaofen, Hewson, Ian, Santos, Ingrid, Illarramendi, Jorge, Semendric, Ines, Menge, Rol, Von Bultzingslowen, Inger, Melo, Maria da Gloria de, Leong, Iona, Fonseca, Isabella, Kalif, Isadora, Carroll, James, Coller, Janet, Beck-Mannagetta, Johann, Bowen, Joanne, Meurer, Jose, McCullough, Ricky, Powers, Jennifer, Gomez, Jesus, Lenjisa, Jimma, jaya Vangara, Leko, Jasna, Fall-Dickson, Jane, Mougeot, Jean-Luc, Fox, Joan, Epstein, Joel, Robijns, Jolien, Wu, Jonn, Palma, Patricio, Amaram-Davila, Jaya, Siderov, Jim, Raber-Durlacher, Judith, Dantas, Juliana, Jasper, Juliana, Monteiro, Juliana, Bruno, Julia, julie pfeffer, Ristivojevic, Julija Jovanovic, Brito, Juliana, Kuriakose, Jyothsna, Kabasawa, Yuji, Dave, Kanan, Barczyszyn, Karin, Lima, Karol Sartori, Secombe, Kate, White, Kate, Cooper, Kate, Katsura, Kouji, Biggs, Karen, Ciarrocca, Katharine, Dennis, Kristopher, Tomizuka, Ken, Hendler, Kevin, Komo, Ikuko, Skallsjö, Kristina, Hodgins, Kristy, Rupel, Katia, Tanaka, Keiko, Kurup, Seema, Gueiros, Luiz, Agatti, Larissa, Garzona-Navas, Laura, Guerra, Letícia, Portela, Leila, Iossi, Leilani, Elting, Linda, Baad-Hansen, Lene, Reeder, Leslie, Lang, Leticia, Menezes, Liciane, Braun, Liliana, Grando, Liliane, Lim, Mathew, Fernandez, Lina, McKeage, Lucy, Campos, Luana, Simonato, Luciana, Muniz, Luciana, van Draanen, Leah, Mizutani, Mieko, Huang, Tsai-Wei, Riad, Mahfujul, Nazar, Mahnoor, Souza, Maíra, Minamisako, Mariana, Pereira, Manoela, Mantelato, Carlos, Diniz-Freitas, Márcio, Montezuma, Marco, Andrade, Marco, Santos, Marcos, Gobbo, Margherita, Fortuna, Maria Caterina, Vitor, Mariana, Marinho, Joana, Markova, Alina, Knuchel, Marlyse, Carlesimo, Marta, Neves, Marta, Mazar, Andrew, Gomez Amarilla, Maria Cristina, Chambers, Mark, Araujo, Melissa de, Melo, Alexandre, Cole, Melody, Elsayed, Mohamed, Fliedner, Monica, Hauer-Jensen, Martin, Bouchacourt, Micaela, Brennan, Michael, Thirlwell, Michael, Nakamura, Michio, Nakagaki, Midori, Rossi, Camila, Miller, Robert, Kaprilian, Mireille, Kase, Michael, Dougan, Michael, Stokman, Monique, Monsen, Ragnhild, Morgan, Alisha, Harding, Jocelyn, Taleghani, Maryam, Genot, Marie-Therese, Seshadri, Mukund, Muzyka, Brian, Batista, Nancy, Gadd, Nancy, Tanda, Naoko, Nasr, Narmin, Garcia, Natália, Lee, Nathan, Palmier, Natalia, Brito-Dellan, Norman, Corbitt, Nancy, Pieralisi, Neli, Serrano, Verônica, Iacovelli, Nicola Alessandro, Blijlevens, Nicole, Sampaio, Norma Lúcia, Karra, Nour, Venkatesh, Niveditha, Yarom, Noam, Borin, Renata Cristina, Lemenchick, Olivia, Mendes, Ondina, Nicolatou-Galitis, Ourania, Shchitka, Vasiliy, Bossi, Paolo, Reis, Paula, Santos, Paulo Sérgio, Fernandez-Ortega, Paz, Parker, Ira, García, Raquel, Fritz, Peter, Peters, Edmund, Gardner, Pamela, Girons, Pierre Saint, Tiwari, Priya, Chaturvedi, Pravin, de Moraes, Tais, Andrade, Priscila, Nair, Raj, Gibson, Rachel, Gururaj, Rachita, Abdalla-Aslan, Ragda, Thota, Raghu, Lalla, Rajesh, Mendes, Rui Amaral, Prado, Raquel Almeida, Ongole, Ravikiran, Taybos, George, Mackey, Regina, Rego, Renata, Camilotti, Renata, Ferrari, Renata, Junior, Renato, Bensadoun, Rene-Jean, Logan, Richard, Sales, Roberta, Zanicotti, Roberta, Tunes, Roberta, Mauceri, Rodolfo, Feitoza, Rosiene, Ruddy, Kathryn, Rybczyk, Cynthia, Trager, Stephanie, Mitsunaga, Sachiyo, Gunathilake, Sahani, Saini, Rajan, Salvestrini, Viola, Mukhopadhyay, Sandip, Angeloz, Sandrina, Sankar S, Pramod, Barbosa, Luciana S Barbosa, Volkova, Elena, Elad, Sharon, Cantoreggi, Sergio, Gordon, Sharon, Brown, Shelly, Janine Tam, Shu Yie, Faleiro, Sibelle, da Silva, Silmara, de Oliveira, Silvia, Jensen, Siri Beier, Skrinjar, Ivana, Beaumont, Sophie, Sperandio, Felipe, Reese, Sandra, Roser, Steven, Seo, Sachiko, van Leeuwen, Stephanie, Sonis, Stephen, Bernard, Stephen, Samuel, Stephen Rajan, Taylor, Stuart, Maitra, Suranjan, Skulski, Susanne, Carlisle, Suzanne, Avon, Sylvie Louise, Yokota, Tomoya, Yurikusa, Takashi, Polvora, Tabata Santos, Kelock, Tabitha, Fernandes, Tauana, Wain, Taylor, Brown, Timothy, Tetsuhito konishi, Ferreira, Thalyta Amanda, Kataoka, Tomoko, Kelly, Thomas, Mori, Takehiko, Higuchi, Tomoko, Saeki, Toshiaki, Tsoukalas, Nikolaos, De Vandeul, Typhaine Maupoint, Usubuchi, Masatoshi, Lacerda, Vanessa, Tilly, Vanessa, Vigarios, Emmanuelle, Villa, Alessandro, Torregrossa, Vinicius, Selvaraj, Vinodh Kumar, Sarmento, Viviane, Heng, Vivien, Gomes-Silva, Wagner, Kandwal, Abhishek, Wilberg, Petter, Miranda e Silva, Wanessa, I'zzah Wan Mohamad Zain, Wan Nor, Park, Wonse, Tissing, Wim, Soga, Yoshihiko, Van Sebille, Bella, Matsuda, Yuhei, Zadik, Yehuda, Cao, Katrina, Cheung, Yin Ting, Fregnani, Eduardo Rodrigues, Van Sebille, Ysabella, Kauark-Fontes, Elisa, McCurdy-Franks, Emma, Finkelstein, Joel, McCarvell, Victoria, Amaral Mendes, Rui, Speksnijder, Caroline Margina, and Wardill, Hannah Rose

Published
2024
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38. Cognitive comorbidities in the rat pilocarpine model of epilepsy

Author

Annunziata Guarino, Paola Pignata, Francesca Lovisari, Laila Asth, Michele Simonato, and Marie Soukupova

Subjects
epilepsy, pilocarpine model, cognitive abilities, comorbidity, rats, Neurology. Diseases of the nervous system, RC346-429
Abstract

Patients with epilepsy are prone to cognitive decline, depression, anxiety and other behavioral disorders. Cognitive comorbidities are particularly common and well-characterized in people with temporal lobe epilepsy, while inconsistently addressed in epileptic animals. Therefore, the aim of this study was to ascertain whether there is good evidence of cognitive comorbidities in animal models of epilepsy, in particular in the rat pilocarpine model of temporal lobe epilepsy. We searched the literature published between 1990 and 2023. The association of spontaneous recurrent seizures induced by pilocarpine with cognitive alterations has been evaluated by using various tests: contextual fear conditioning (CFC), novel object recognition (NOR), radial and T-maze, Morris water maze (MWM) and their variants. Combination of results was difficult because of differences in methodological standards, in number of animals employed, and in outcome measures. Taken together, however, the analysis confirmed that pilocarpine-induced epilepsy has an effect on cognition in rats, and supports the notion that this is a valid model for assessment of cognitive temporal lobe epilepsy comorbidities in preclinical research.

Published
2024
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39. Anisotropic superconductivity induced at a hybrid superconducting-semiconducting interface

Author

Kamlapure, Anand, Simonato, Manuel, Sierda, Emil, Steinbrecher, Manuel, Kamber, Umut, Knol, Elze J., Krogstrup, Peter, Katsnelson, Mikhail I., Rösner, Malte, and Khajetoorians, Alexander Ako

Subjects
Condensed Matter - Superconductivity, Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

Epitaxial semiconductor-superconductor heterostructures are promising as a platform for gate-tunable superconducting electronics. Thus far, the superconducting properties in such hybrid systems have been predicted based on simplified hybridization models which neglect the electronic structure that can arise at the interface. Here, we demonstrate that the hybrid electronic structure derived at the interface between semiconducting black phosphorus and atomically thin films of lead can drastically modify the superconducting properties of the thin metallic film. Using ultra-low temperature scanning tunneling microscopy and spectroscopy, we ascertain the moir\'e structure driven by the interface, and observe a strongly anisotropic renormalization of the superconducting gap and vortex structure of the lead film. Based on density functional theory, we attribute the renormalization of the superconductivity to weak hybridization at the interface where the anisotropic characteristics of the semiconductor band structure is imprinted on the Fermi surface of the superconductor. Based on a hybrid two-band model, we link this hybridization-driven renormalization to a weighting of the superconducting order parameter that quantitatively reproduces the measured spectra. These results illustrate the effect of interfacial hybridization at superconductor-semiconductor heterostructures, and pathways for engineering quantum technologies based on gate-tunable superconducting electronics.

Published
2021

40. A Systematic Review of Problematic Internet Use in Children, Adolescents, and Adults with Autism Spectrum Disorder

Author

Claude L. Normand, Marisa H. Fisher, Isabelle Simonato, Stéphanie-M. Fecteau, and Marie-Hélène Poulin

Abstract

This systematic review was conducted to identify the literature examining the prevalence of problematic internet use (PIU) in individuals with autism spectrum disorder (ASD), the difference in prevalence of PIU between those with and without ASD, and the correlates of PIU in ASD. Ten studies were identified. The eight studies with comparison groups reported that individuals with ASD had more symptoms of or scored higher on PIU. Correlates of PIU included time spent online and age at which individuals first went online, as well as depression, inattention, hyperactivity, impulsivity, opposition, and escapism. Results indicate that additional research is needed to examine PIU in adults with ASD and the causal relation of factors related to PIU in ASD through longitudinal studies.

Published
2022
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41. Outcomes and treatment failure after open or robotic ureteral reconstruction for iatrogenic injuries

Author

Marta Rossanese, Gianluca Giannarini, Riccardo Scalia, Luciano Macchione, Alessandro Crestani, Alchiede Simonato, and Vincenzo Ficarra

Subjects
complications, injury, reconstructive surgery, stricture, ureter, Diseases of the genitourinary system. Urology, RC870-923
Abstract

Abstract Objectives The aim of this study is to assess the aetiology, perioperative outcomes and treatment failure of contemporary patients undergoing open or robot‐assisted ureteral reconstruction for iatrogenic injuries. Patients and methods We retrospectively analysed consecutive patients who underwent ureteral reconstruction for iatrogenic injuries at two academic centres 07/2013 and 06/2022. A variety of open or robot‐assisted procedures were performed, including uretero‐cystoneostomy, Boari bladder flap, uretero‐ureterostomy, ileal replacement and pyelo‐ureteroplasty. All procedures were performed by a single surgeon with extensive experience in open and robot‐assisted surgery and preference‐based management. Outcome measures were aetiology, estimated blood loss, length of stay, postoperative complications and treatment failure, defined as upper tract obstruction requiring permanent urinary drainage. We also planned a subgroup analysis comparing the outcomes between open and robot‐assisted procedures. Results Fifty‐nine patients were included. Most injuries were consequent to endourological procedures (44%). The most frequently performed procedures were uretero‐cystoneostomy (49.2%) and Boari bladder flap (32.2%). Forty (67.8%) were open, and 19 (32.2%) were robot‐assisted procedures. Major postoperative complications were recorded in seven (11.9%) patients. After a median follow‐up of 42 months (interquartile range 12–24), treatment failure was observed in seven (11.9%) cases. Robot‐assisted versus open procedures were associated with decreased estimated blood loss (p = 0.01), length of stay (p

Published
2023
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43. The Impact of Selected Ingredients on the Predicted Glycemic Index and Technological Properties of Bread

Author

Ilaria Pasqualoni, Roberta Tolve, Barbara Simonato, and Federico Bianchi

Subjects
low glycemic index, chickpea flour, dietary fiber, resistant starches, red chicory by-product powder, Chemical technology, TP1-1185
Abstract

Bread, a staple food consumed worldwide, plays a pivotal role in nutrition. Nevertheless, it is to be underlined that white bread is classified as a high glycemic index food, and its frequent consumption can lead to rapid increases in blood glucose, potentially causing metabolic stress and contributing to insulin resistance and type 2 diabetes. So, there is a growing interest in bread formulations with ingredients that can lower its GI. With this view, bread was formulated, substituting wheat with chickpea flour, red chicory powder, and three distinct types of resistant starch. The results showed the different resistant starches’ impacts on the glycemic index reduction. Specifically, chemically modified tapioca RS IV produced a bread formulation with a low predicted glycemic index (pGI < 55). Retrograded starch from tapioca (RS III) allows the bread to reach a pGI value of 55, the upper value for classifying a food as low pGI. The retrograded starch from corn (RS III) allows a decrease in the bread’s glycemic index, but the product is still classified as ‘high pGI’ (>70). Moreover, the addition of by-products rich in polyphenols contributes to a lowering of the pGI. Concerning the technological parameters, the outcome revealed an increase in the moisture content across all the newly formulated samples compared to the control. At the same time, the volume and specific volume showed a decrease. The newly formulated samples exhibited a higher baking loss, particularly when incorporating resistant starch, which increased the hardness and chewiness with decreased cohesiveness. In conclusion, incorporating chickpea flour, red chicory powder, and tapioca-resistant starch (RS III and IV) offers a promising strategy for producing high-fiber bread with a low glycemic index, catering to health-conscious consumers.

Published
2024
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44. Fermentation Performances and Aroma Contributions of Selected Non-Saccharomyces Yeasts for Cherry Wine Production

Author

Federico Bianchi, Michele Avesani, Marilinda Lorenzini, Giacomo Zapparoli, and Barbara Simonato

Subjects
cherry wine, yeast, Hanseniaspora, alcoholic beverage, volatile chemical compounds, Chemical technology, TP1-1185
Abstract

This study evaluates the fermentation performances of non-Saccharomyces strains in fermenting cherry must from Italian cherries unsuitable for selling and not intended to be consumed fresh, and their effects on the chemical composition of the resulting wine. Fermentation trials in 100 and 500 mL of must were carried out to select 21 strains belonging to 11 non-Saccharomyces species. Cherry wines obtained by six select strains were chemically analyzed for fixed and volatile compounds. Quantitative data were statistically analyzed by agglomerative hierarchical clustering, partial least squared discriminant analysis, and principal component analysis. Wines revealed significant differences in their composition. Lactic acid and phenylethyl acetate levels were very high in wines produced by Lachancea and Hanseniaspora, respectively. Compared to S. cerevisiae wine, non-Saccharomyces wines had a lower content of fatty acid ethyl esters 4-vinyl guaiacol and 4-vinyl phenol. The multivariate analysis discriminated between wines, demonstrating the different contributions of each strain to aroma components. Specifically, all wines from non-Saccharomyces strains were kept strictly separate from the control wine. This study provided comprehensive characterization traits for non-conventional strains that enhance the aroma complexity of cherry-based wine. The use of these yeasts in cherry wine production appears promising. Further investigation is required to ascertain their suitability for larger-scale fermentation.

Published
2024
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49. The Tenth Visual Object Tracking VOT2022 Challenge Results

Author

Kristan, Matej, Leonardis, Aleš, Matas, Jiří, Felsberg, Michael, Pflugfelder, Roman, Kämäräinen, Joni-Kristian, Chang, Hyung Jin, Danelljan, Martin, Zajc, Luka Čehovin, Lukežič, Alan, Drbohlav, Ondrej, Björklund, Johanna, Zhang, Yushan, Zhang, Zhongqun, Yan, Song, Yang, Wenyan, Cai, Dingding, Mayer, Christoph, Fernández, Gustavo, Ben, Kang, Bhat, Goutam, Chang, Hong, Chen, Guangqi, Chen, Jiaye, Chen, Shengyong, Chen, Xilin, Chen, Xin, Chen, Xiuyi, Chen, Yiwei, Chen, Yu-Hsi, Chen, Zhixing, Cheng, Yangming, Ciaramella, Angelo, Cui, Yutao, Džubur, Benjamin, Dasari, Mohana Murali, Deng, Qili, Dhar, Debajyoti, Di, Shangzhe, Nardo, Emanuel Di, Du, Daniel K., Dunnhofer, Matteo, Fan, Heng, Feng, Zhenhua, Fu, Zhihong, Gao, Shang, Gorthi, Rama Krishna, Granger, Eric, Gu, Q. H., Gupta, Himanshu, He, Jianfeng, He, Keji, Huang, Yan, Jangid, Deepak, Ji, Rongrong, Jiang, Cheng, Jiang, Yingjie, Lawin, Felix Järemo, Kang, Ze, Kiran, Madhu, Kittler, Josef, Lai, Simiao, Lan, Xiangyuan, Lee, Dongwook, Lee, Hyunjeong, Lee, Seohyung, Li, Hui, Li, Ming, Li, Wangkai, Li, Xi, Li, Xianxian, Li, Xiao, Li, Zhe, Lin, Liting, Ling, Haibin, Liu, Bo, Liu, Chang, Liu, Si, Lu, Huchuan, Cruz, Rafael M. O., Ma, Bingpeng, Ma, Chao, Ma, Jie, Ma, Yinchao, Martinel, Niki, Memarmoghadam, Alireza, Micheloni, Christian, Moallem, Payman, Nguyen-Meidine, Le Thanh, Pan, Siyang, Park, ChangBeom, Paudel, Danda, Paul, Matthieu, Peng, Houwen, Robinson, Andreas, Rout, Litu, Shan, Shiguang, Simonato, Kristian, Song, Tianhui, Song, Xiaoning, Sun, Chao, Sun, Jingna, Tang, Zhangyong, Timofte, Radu, Tsai, Chi-Yi, Gool, Luc Van, Verma, Om Prakash, Wang, Dong, Wang, Fei, Wang, Liang, Wang, Liangliang, Wang, Lijun, Wang, Limin, Wang, Qiang, Wu, Gangshan, Wu, Jinlin, Wu, Xiaojun, Xie, Fei, Xu, Tianyang, Xu, Wei, Xu, Yong, Xu, Yuanyou, Xue, Wanli, Xun, Zizheng, Yan, Bin, Yang, Dawei, Yang, Jinyu, Yang, Wankou, Yang, Xiaoyun, Yang, Yi, Yang, Yichun, Yang, Zongxin, Ye, Botao, Yu, Fisher, Yu, Hongyuan, Yu, Jiaqian, Yu, Qianjin, Yu, Weichen, Ze, Kang, Zhai, Jiang, Zhang, Chengwei, Zhang, Chunhu, Zhang, Kaihua, Zhang, Tianzhu, Zhang, Wenkang, Zhang, Zhibin, Zhang, Zhipeng, Zhao, Jie, Zhao, Shaochuan, Zheng, Feng, Zheng, Haixia, Zheng, Min, Zhong, Bineng, Zhu, Jiawen, Zhu, Xuefeng, Zhuang, Yueting, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Karlinsky, Leonid, editor, Michaeli, Tomer, editor, and Nishino, Ko, editor

Published
2023
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