134 results on '"Sinner M"'
Search Results
2. Heart failure, female sex and atrial fibrillation are the main drivers of atrial cardiomyopathy in cardiac surgery patients: results from the CATCH ME consortium
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Winters, J, primary, Zeemering, S, additional, Isaacs, A, additional, Kawczynski, M, additional, Casadei, B, additional, Fabritz, L, additional, Kirchhof, P, additional, Guasch, E, additional, Chua, W, additional, Hatem, S, additional, Sinner, M F, additional, Kaab, S, additional, Verheule, S, additional, Stoll, M, additional, and Schotten, U, additional
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- 2023
- Full Text
- View/download PDF
3. Etiological and molecular determinants of atrial endomysial fibrosis: results from the CATCH ME consortium
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Winters, J, primary, Kawczynski, M, additional, Zeemering, S, additional, Isaacs, A, additional, Casadei, B, additional, Fabritz, L, additional, Kirchhof, P, additional, Chua, W, additional, Guasch, E, additional, Sinner, M F, additional, Kaab, S, additional, Hatem, S, additional, Verheule, S, additional, Stoll, M, additional, and Schotten, U, additional
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- 2023
- Full Text
- View/download PDF
4. High-density Mapping Guided Pulmonary Vein Isolation for Treatment of Atrial Fibrillation - Two-year clinical outcome of a single center experience
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Siebermair, J., Neumann, B., Risch, F., Riesinger, L., Vonderlin, N., Koehler, M., Lackermaier, K., Fichtner, S., Rizas, K., Sattler, S. M., Sinner, M. F., Kääb, S., Estner, H. L., and Wakili, R.
- Published
- 2019
- Full Text
- View/download PDF
5. CLINICAL 1 YEAR EXPERIENCE WITH A NOVEL MULTIPOLAR IRRIGATED ABLATION CATHETER IN AF ABLATION PROCEDURES: 388
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Wakili, R., Siebermair, J., Fichtner, S., Sattler, S., Sinner, M. F., Klocker, E., Kaab, S., and Estner, H. L.
- Published
- 2015
6. Genetik von Vorhofflimmern: seltene Mutationen, häufige Genvarianten und klinische Relevanz?
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Sinner, M. F., Pfeufer, A., and Kääb, S.
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- 2006
- Full Text
- View/download PDF
7. Power increases using wind direction spatial filtering for wind farm control: Evaluation using FLORIS, modified for dynamic settings
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Sinner, M., primary, Simley, E., additional, King, J., additional, Fleming, P., additional, and Pao, L. Y., additional
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- 2021
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- View/download PDF
8. Improving knowledge about prostate cancer: the development of an educational program for African-Americans
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List, MA, Sinner, M, and Chodak, GW
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- 1999
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- View/download PDF
9. Telomere length is associated with atrial fibrillation
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Sinner, M, primary, Kupka, D, additional, Wilfert, W, additional, Waldenberger, M, additional, Peters, A, additional, Holdt, L, additional, and Kaab, S, additional
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- 2020
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- View/download PDF
10. Rationale and design of the EU-CERT-ICD prospective study: comparative effectiveness of prophylactic ICD implantation
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Zabel, Markus, Sticherling, Christian, Willems, Rik, Lubinski, Andrzej, Bauer, Axel, Bergau, Leonard, Braunschweig, Frieder, Brugada, Josep, Brusich, Sandro, Conen, David, Cygankiewicz, Iwona, Flevari, Panagiota, Taborsky, Milos, Hansen, Jim, Hasenfuss, Gerd, Hatala, Robert, Huikuri, Heikki V, Iovev, Svetoslav, Kaeaeb, Stefan, Kaliska, Gabriela, Kasprzak, Jaroslaw D, Luethje, Lars, Malik, Marek, Novotny, Tomas, Pavlovic, Nikola, Schmidt, Georg, Shalganov, Tchavdar, Sritharan, Rajeeva, Schloegl, Simon, Traykov, Vassil, Tuinenburg, Anton E, Velchev, Vasil, Vos, Marc A, Willich, Stefan N, Friede, Tim, Svendsen, Jesper Hastrup, Merkely, Bela, Seegers, J, Munoz-Exposito, P, Tichelbacker, T, Kirovo, A, Joerss, K, Macken, J, Misdaq, M, Rudolph, K, Mueller, A, Dommasch, M, Sinnecker, D, Sinner, M, Dissmann, R, Burmester, U, Behrens, S, Gregor, M, Stefanow, S, Rueb, N, Wolpert, C, Bimmel, D, Lieberz, C, Maier, L, Schwinger, R, Blaschke, F, Pieske, B, Groenefeld, G, Klein, G, Gardiwal, A, Szeplaki, G, Perge, P, Nossan, J Szavits, Rotkvic, L, Manola, S, Vinter, O, Benko, I, Brusic, S, Avdovic, E, Klasan, M, Bakotic, Z, Anic, A, Kowalczyk, E, Kucejko, T, Czechowska, A, Wybor, K, Ptaszynski, P, Qavoq, H, Guzik, P, Krauze, T, Sterlinski, M, Svetlosak, M, Martinek, J, Thamsborg, K, Schloett-Hyldelund, IM, Laage-Petersen, J, Vandenberk, B, van Soest, S, Giesebart, S, Kozak, M, Galuszka, J, Wijers, S, Dunnink, A, Sprenkeler, D, Arbelo, E, Trucco, E, Vidorreta, S, Kentta, T, Pelli, A, Huikuri, P, Koski, P, Karlsson, H, Ersgaard, D, Platonov, P, Klingenheben, T, Scharfe, M, Reinhold, T, Cree, M, Hnatkova, K, Gerhardt, J, Rizas, K, Hamm, W, Roever, C, Harden, M, Kessel, B, Berg, A, Apel, S, Walker, F, Kirchhof, N, Goerlitz, A, Molitor, A, Heinrich, J, Annetzberger, S, Fuchs, B, Landwehr, A, Merk, A, Wilke, A, Hennecke, C, and Mansch, R
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Science & Technology ,Cardiac & Cardiovascular Systems ,SEX-DIFFERENCES ,SEATTLE HEART-FAILURE ,RISK STRATIFICATION ,EJECTION FRACTION ,Sudden cardiac death ,Risk factors ,MYOCARDIAL-INFARCTION ,CARDIOVERTER-DEFIBRILLATOR THERAPY ,Implantable cardioverter defibrillator ,Cardiovascular System & Cardiology ,APPROPRIATE SHOCKS ,Mortality ,PRIMARY PREVENTION ,PROPORTIONAL RISK ,Life Sciences & Biomedicine - Abstract
AIMS: The clinical effectiveness of primary prevention implantable cardioverter defibrillator (ICD) therapy is under debate. The EUropean Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators (EU-CERT-ICD) aims to assess its current clinical value. METHODS AND RESULTS: The EU-CERT-ICD is a prospective investigator-initiated non-randomized, controlled, multicentre observational cohort study performed in 44 centres across 15 European Union countries. We will recruit 2250 patients with ischaemic or dilated cardiomyopathy and a guideline indication for primary prophylactic ICD implantation. This sample will include 1500 patients at their first ICD implantation and 750 patients who did not receive a primary prevention ICD despite having an indication for it (non-randomized control group). The primary endpoint is all-cause mortality; the co-primary endpoint in ICD patients is time to first appropriate shock. Secondary endpoints include sudden cardiac death, first inappropriate shock, any ICD shock, arrhythmogenic syncope, revision procedures, quality of life, and cost-effectiveness. At baseline (and prior to ICD implantation if applicable), all patients undergo 12-lead electrocardiogram (ECG) and Holter ECG analysis using multiple advanced methods for risk stratification as well as detailed documentation of clinical characteristics and laboratory values. Genetic biobanking is also organized. As of August 2018, baseline data of 2265 patients are complete. All subjects will be followed for up to 4.5 years. CONCLUSIONS: The EU-CERT-ICD study will provide a necessary update about clinical effectiveness of primary prophylactic ICD implantation. This study also aims for improved risk stratification and patient selection using clinical and ECG risk markers. ispartof: ESC HEART FAILURE vol:6 issue:1 pages:182-193 ispartof: location:England status: published
- Published
- 2019
11. Production of a high level of cellulase-free xylanase by the thermophilic fungus Thermomyces lanuginosus in laboratory and pilot scales using lignocellulosic materials
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Gomes, J., Purkarthofer, H., Hayn, M., Kapplmüller, J., Sinner, M., and Steiner, W.
- Published
- 1993
- Full Text
- View/download PDF
12. Rationale and design of the EU‐CERT‐ICD prospective study:comparative effectiveness of prophylactic ICD implantation
- Author
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Zabel, M. (Markus), Sticherling, C. (Christian), Willems, R. (Rik), Lubinski, A. (Andrzej), Bauer, A. (Axel), Bergau, L. (Leonard), Braunschweig, F. (Frieder), Brugada, J. (Josep), Brusich, S. (Sandro), Conen, D. (David), Cygankiewicz, I. (Iwona), Flevari, P. (Panagiota), Taborsky, M. (Milos), Hansen, J. (Jim), Hasenfuss, G. (Gerd), Hatala, R. (Robert), Huikuri, H. V. (Heikki V.), Iovev, S. (Svetoslav), Kaeaeb, S. (Stefan), Kaliska, G. (Gabriela), Kasprzak, J. D. (Jaroslaw D.), Luethje, L. (Lars), Malik, M. (Marek), Novotny, T. (Tomas), Pavlovic, N. (Nikola), Schmidt, G. (Georg), Shalganov, T. (Tchavdar), Sritharan, R. (Rajeeva), Schloegl, S. (Simon), Nossan, J. S. (Janko Szavits), Traykov, V. (Vassil), Tuinenburg, A. E. (Anton E.), Velchev, V. (Vasil), Vos, M. A. (Marc A.), Willich, S. N. (Stefan N.), Friede, T. (Tim), Svendsen, J. H. (Jesper Hastrup), Merkely, B. (Bela), Seegers, J. (J.), Munoz-Exposito, P. (P.), Tichelbacker, T. (T.), Kirovo, A. (A.), Sritharan, R. (R.), Joerss, K. (K.), Macken, J. (J.), Misdaq, M. (M.), Rudolph, K. (K.), Schmidt, G. (G.), Mueller, A. (A.), Dommasch, M. (M.), Sinnecker, D. (D.), Sinner, M. (M.), Bauer, A. (A.), Dissmann, R. (R.), Burmester, U. (U.), Behrens, S. (S.), Gregor, M. (M.), Stefanow, S. (S.), Rueb, N. (N.), Wolpert, C. (C.), Bimmel, D. (D.), Lieberz, C. (C.), Maier, L. (L.), Schwinger, R. (R.), Blaschke, F. (F.), Pieske, B. (B.), Groenefeld, G. (G.), Klein, G. (G.), Gardiwal, A. (A.), Merkely, B. (B.), Szeplaki, G. (G.), Perge, P. (P.), Nossan, J. S. (J. Szavits), Rotkvic, L. (L.), Pavlovic, N. (N.), Manola, S. (S.), Vinter, O. (O.), Benko, I. (I.), Brusic, S. (S.), Avdovic, E. (E.), Klasan, M. (M.), Bakotic, Z. (Z.), Anic, A. (A.), Lubinski, A. (A.), Kowalczyk, E. (E.), Kucejko, T. (T.), Czechowska, A. (A.), Wybor, K. (K.), Cygankiewicz, I. (I.), Ptaszynski, P. (P.), Kasprzak, J. (J.), Qavoq, H. (H.), Guzik, P. (P.), Krauze, T. (T.), Sterlinski, M. (M.), Hatala, R. (R.), Svetlosak, M. (M.), Kaliska, G. (G.), Martinek, J. (J.), Thamsborg, K. (K.), Hansen, J. (J.), Schloett-Hyldelund, I. M. (I. M.), Laage-Petersen, J. (J.), Willems, R. (R.), Vandenberk, B. (B.), van Soest, S. (S.), Traykov, V. (V.), Iovev, S. (S.), Shalganov, T. (T.), Sticherling, C. (C.), Conen, D. (D.), Giesebart, S. (S.), Novotny, T. (T.), Kozak, M. (M.), Taborsky, M. (M.), Galuszka, J. (J.), Tuinenburg, A. E. (A. E.), Wijers, S. (S.), Dunnink, A. (A.), Sprenkeler, D. (D.), Brugada, J. (J.), Arbelo, E. (E.), Trucco, E. (E.), Vidorreta, S. (S.), Huikuri, H. (H.), Kentta, T. (T.), Pelli, A. (A.), Huikuri, P. (P.), Koski, P. (P.), Braunschweig, F. (F.), Karlsson, H. (H.), Ersgaard, D. (D.), Platonov, P. (P.), Klingenheben, T. (T.), Scharfe, M. (M.), Reinhold, T. (T.), Cree, M. (M.), Hnatkova, K. (K.), Gerhardt, J. (J.), Rizas, K. (K.), Hamm, W. (W.), Roever, C. (C.), Harden, M. (M.), Kessel, B. (B.), Berg, A. (A.), Apel, S. (S.), Walker, F. (F.), Kirchhof, N. (N.), Goerlitz, A. (A.), Molitor, A. (A.), Heinrich, J. (J.), Annetzberger, S. (S.), Fuchs, B. (B.), Landwehr, A. (A.), Merk, A. (A.), Wilke, A. (A.), Hennecke, C. (C.), Mansch, R. (R.), Zabel, M. (Markus), Sticherling, C. (Christian), Willems, R. (Rik), Lubinski, A. (Andrzej), Bauer, A. (Axel), Bergau, L. (Leonard), Braunschweig, F. (Frieder), Brugada, J. (Josep), Brusich, S. (Sandro), Conen, D. (David), Cygankiewicz, I. (Iwona), Flevari, P. (Panagiota), Taborsky, M. (Milos), Hansen, J. (Jim), Hasenfuss, G. (Gerd), Hatala, R. (Robert), Huikuri, H. V. (Heikki V.), Iovev, S. (Svetoslav), Kaeaeb, S. (Stefan), Kaliska, G. (Gabriela), Kasprzak, J. D. (Jaroslaw D.), Luethje, L. (Lars), Malik, M. (Marek), Novotny, T. (Tomas), Pavlovic, N. (Nikola), Schmidt, G. (Georg), Shalganov, T. (Tchavdar), Sritharan, R. (Rajeeva), Schloegl, S. (Simon), Nossan, J. S. (Janko Szavits), Traykov, V. (Vassil), Tuinenburg, A. E. (Anton E.), Velchev, V. (Vasil), Vos, M. A. (Marc A.), Willich, S. N. (Stefan N.), Friede, T. (Tim), Svendsen, J. H. (Jesper Hastrup), Merkely, B. (Bela), Seegers, J. (J.), Munoz-Exposito, P. (P.), Tichelbacker, T. (T.), Kirovo, A. (A.), Sritharan, R. (R.), Joerss, K. (K.), Macken, J. (J.), Misdaq, M. (M.), Rudolph, K. (K.), Schmidt, G. (G.), Mueller, A. (A.), Dommasch, M. (M.), Sinnecker, D. (D.), Sinner, M. (M.), Bauer, A. (A.), Dissmann, R. (R.), Burmester, U. (U.), Behrens, S. (S.), Gregor, M. (M.), Stefanow, S. (S.), Rueb, N. (N.), Wolpert, C. (C.), Bimmel, D. (D.), Lieberz, C. (C.), Maier, L. (L.), Schwinger, R. (R.), Blaschke, F. (F.), Pieske, B. (B.), Groenefeld, G. (G.), Klein, G. (G.), Gardiwal, A. (A.), Merkely, B. (B.), Szeplaki, G. (G.), Perge, P. (P.), Nossan, J. S. (J. Szavits), Rotkvic, L. (L.), Pavlovic, N. (N.), Manola, S. (S.), Vinter, O. (O.), Benko, I. (I.), Brusic, S. (S.), Avdovic, E. (E.), Klasan, M. (M.), Bakotic, Z. (Z.), Anic, A. (A.), Lubinski, A. (A.), Kowalczyk, E. (E.), Kucejko, T. (T.), Czechowska, A. (A.), Wybor, K. (K.), Cygankiewicz, I. (I.), Ptaszynski, P. (P.), Kasprzak, J. (J.), Qavoq, H. (H.), Guzik, P. (P.), Krauze, T. (T.), Sterlinski, M. (M.), Hatala, R. (R.), Svetlosak, M. (M.), Kaliska, G. (G.), Martinek, J. (J.), Thamsborg, K. (K.), Hansen, J. (J.), Schloett-Hyldelund, I. M. (I. M.), Laage-Petersen, J. (J.), Willems, R. (R.), Vandenberk, B. (B.), van Soest, S. (S.), Traykov, V. (V.), Iovev, S. (S.), Shalganov, T. (T.), Sticherling, C. (C.), Conen, D. (D.), Giesebart, S. (S.), Novotny, T. (T.), Kozak, M. (M.), Taborsky, M. (M.), Galuszka, J. (J.), Tuinenburg, A. E. (A. E.), Wijers, S. (S.), Dunnink, A. (A.), Sprenkeler, D. (D.), Brugada, J. (J.), Arbelo, E. (E.), Trucco, E. (E.), Vidorreta, S. (S.), Huikuri, H. (H.), Kentta, T. (T.), Pelli, A. (A.), Huikuri, P. (P.), Koski, P. (P.), Braunschweig, F. (F.), Karlsson, H. (H.), Ersgaard, D. (D.), Platonov, P. (P.), Klingenheben, T. (T.), Scharfe, M. (M.), Reinhold, T. (T.), Cree, M. (M.), Hnatkova, K. (K.), Gerhardt, J. (J.), Rizas, K. (K.), Hamm, W. (W.), Roever, C. (C.), Harden, M. (M.), Kessel, B. (B.), Berg, A. (A.), Apel, S. (S.), Walker, F. (F.), Kirchhof, N. (N.), Goerlitz, A. (A.), Molitor, A. (A.), Heinrich, J. (J.), Annetzberger, S. (S.), Fuchs, B. (B.), Landwehr, A. (A.), Merk, A. (A.), Wilke, A. (A.), Hennecke, C. (C.), and Mansch, R. (R.)
- Abstract
Aims: The clinical effectiveness of primary prevention implantable cardioverter defibrillator (ICD) therapy is under debate. The EUropean Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators (EU‐CERT‐ICD) aims to assess its current clinical value. Methods and results: The EU‐CERT‐ICD is a prospective investigator‐initiated non‐randomized, controlled, multicentre observational cohort study performed in 44 centres across 15 European Union countries. We will recruit 2250 patients with ischaemic or dilated cardiomyopathy and a guideline indication for primary prophylactic ICD implantation. This sample will include 1500 patients at their first ICD implantation and 750 patients who did not receive a primary prevention ICD despite having an indication for it (non‐randomized control group). The primary endpoint is all‐cause mortality; the co‐primary endpoint in ICD patients is time to first appropriate shock. Secondary endpoints include sudden cardiac death, first inappropriate shock, any ICD shock, arrhythmogenic syncope, revision procedures, quality of life, and cost‐effectiveness. At baseline (and prior to ICD implantation if applicable), all patients undergo 12‐lead electrocardiogram (ECG) and Holter ECG analysis using multiple advanced methods for risk stratification as well as detailed documentation of clinical characteristics and laboratory values. Genetic biobanking is also organized. As of August 2018, baseline data of 2265 patients are complete. All subjects will be followed for up to 4.5 years. Conclusions: The EU‐CERT‐ICD study will provide a necessary update about clinical effectiveness of primary prophylactic ICD implantation. This study also aims for improved risk stratification and patient selection using clinical and ECG risk markers.
- Published
- 2019
13. P5662Development of a prognostic model for prevalent atrial fibrillation using individual patient data: Results of CATCH ME
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Chua, W, primary, Easter, C L, additional, Guasch, E, additional, Sitch, A, additional, Casadei, B, additional, Haase, D, additional, Hatem, S, additional, Kaab, S, additional, Mont, L, additional, Schotten, U, additional, Sinner, M, additional, Hemming, K, additional, Deeks, J J, additional, Kirchhof, P, additional, and Fabritz, L, additional
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- 2019
- Full Text
- View/download PDF
14. Production of Sugars from Lignocellulosic Wastes Basic Research and Pilot Studies
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Esterbauer, H., primary, Hayn, M., additional, Sattler, W., additional, Steiner, W., additional, Steinmüller, H., additional, Steiner, Th., additional, and Sinner, M., additional
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- 1991
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- View/download PDF
15. Screening for Atrial Fibrillation
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Naik, N, Moran, P, Mcmanus, D, Matsumoto, K, Marzona, I, Martinek, M, Mant, J, Ma, C, Løchen, Ml, Kollios, G, Kim, Yh, Keane, K, Kaab, S, Johnson, L, Jackson, R, Heidbuchel, H, Sinner, M, Bernard, Anne, Schilling, R, Babuty, Dominique, Savalieva, I, Angoulvant, Denis, Rudd, A, Clementy, Nicolas, Ribeiro, A, Bernard, Louis, Reidpath, D, Bourguignon, Thierry, Prabhakaran, D, Pericart, Lauriane, Ngarmukos, T, Fauchier, Laurent, Hatala, R, Halcox, J, Guerra, A, Grubb, N, Gray, H, Geanta, M, Frykman, V, Fay, M, Ezekowitz, M, Du, X, Doughty, R, Dixen, U, Davis, S, Crijns, H, Connolly, S, Christophersen, I, Chen, Sa, Chan, Ny, Caorsi, Wr, Bury, G, Breithardt, G, Berge, T, Al-Kalili, F, Al Awwad, A, Yan, Bryan, Wachter, Rolf, Verma, Atul, van Gelder, Isabelle, Uittenbogaart, Steven, Tveit, Arnljot, Turakhia, Mintu, Tieleman, Robert, Themistoclakis, Sakis, Svennberg, Emma, Svendsen, Jesper, Steinhubl, Steven, Siu, Chung-Wah, Schnabel, Renate, Sandhu, Roopinder, Rienstra, Michiel, Puererfellner, Helmut, Potpara, Tatjana, Poppe, Katrina, Piccini, Jonathan, Orchard, Jessica, Neubeck, Lis, Martinez, Carlos, Mairesse, Georges, Lowres, Nicole, Lobban, Trudie, Lip, Gregory, Levin, Lars-Åke, Lee, Vivian, Krieger, Derk, Kowey, Peter, Kirchhof, Paulus, Kamel, Hooman, Hills, Mellanie, Hillis, Graham, Harbison, Joseph, Hankey, Graeme, Gwynne, Kylie, Glotzer, Taya, Gladstone, David, Gersh, Bernard, Friberg, Leif, Fitzmaurice, David, Engdahl, Johan, Conen, David, Chao, Tze-Fan, Brandes, Axel, Brachmann, Johannes, Boriani, Giuseppe, Benjamin, Emelia, Antoniou, Sotiris, Wijeratne, T, Anderson, Craig, Walker, N, Albert, Christine, Verbiest van Gurp, N, Wang, Jiguang, Ushiyama, S, Rosenqvist, Mårten, Topol, E, Healey, Jeffrey, Takahashi, N, Calkins, Hugh, Suwanwela, N, Camm, John, Stewart, S, Freedman, Ben, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Éducation Éthique Santé EA 7505 (EES), Université de Tours (UT), EA4245 - Transplantation, Immunologie, Inflammation [Tours] (T2i), Service de Médecine Interne et Maladies Infectieuses [Tours], Service de Cardiologie (CHU Trousseau, Tours), CHU Trousseau [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Cellules Dendritiques, Immunomodulation et Greffes, Service de Cardiologie B, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), Johns Hopkins University (JHU), Centre for Epidemiological Studies and Clinical Trials, Shanghai Jiao Tong University School of Medicine-Ruijin Hospital, Black Mountain Laboratories, Commonwealth Scientific and Industrial Research Organisation [Canberra] (CSIRO), Biological and Environmental Sciences, University of Stirling, Boston University School of Medicine (BUSM), Boston University [Boston] (BU), Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Coburg Hospital, and Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)
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screening ,atrial fibrillation ,stroke ,[SHS]Humanities and Social Sciences - Abstract
International audience; Approximately 10% of ischemic strokes are associated with atrial fibrillation (AF) first diagnosed at the time of stroke. Detecting asymptomatic AF would provide an opportunity to prevent these strokes by instituting appropriate anticoagulation. The AF-SCREEN international collaboration was formed in September 2015 to promote discussion and research about AF screening as a strategy to reduce stroke and death and to provide advocacy for implementation of country-specific AF screening programs. During 2016, 60 expert members of AF-SCREEN, including physicians, nurses, allied health professionals, health economists, and patient advocates, were invited to prepare sections of a draft document. In August 2016, 51 members met in Rome to discuss the draft document and consider the key points arising from it using a Delphi process. These key points emphasize that screen-detected AF found at a single timepoint or by intermittent ECG recordings over 2 weeks is not a benign condition and, with additional stroke factors, carries sufficient risk of stroke to justify consideration of anticoagulation. With regard to the methods of mass screening, handheld ECG devices have the advantage of providing a verifiable ECG trace that guidelines require for AF diagnosis and would therefore be preferred as screening tools. Certain patient groups, such as those with recent embolic stroke of uncertain source (ESUS), require more intensive monitoring for AF. Settings for screening include various venues in both the community and the clinic, but they must be linked to a pathway for appropriate diagnosis and management for screening to be effective. It is recognized that health resources vary widely between countries and health systems, so the setting for AF screening should be both country- and health system-specific. Based on current knowledge, this white paper provides a strong case for AF screening now while recognizing that large randomized outcomes studies would be helpful to strengthen the evidence base.
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- 2017
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16. P829Bipolar voltage variability in left atrial ultra-high density 3D maps (Rhythmia) in patients undergoing pulmonary vein isolation
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Lackermair, K, primary, Kellner, S, additional, Riesinger, L, additional, Rizas, K, additional, Sinner, M F, additional, Fichtner, S, additional, and Estner, H L, additional
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- 2018
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- View/download PDF
17. 116Acute alcohol consumption and effects on cardiac excitation, conduction, and repolarization. Results from the MunichBREW Study
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Sinner, M F, primary, Drobesch, C, additional, Herbel, R, additional, Rizas, K, additional, Massberg, S, additional, Kaab, S, additional, and Brunner, S, additional
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- 2018
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18. P431Bipolar voltage variability in left atrial ultra-high density 3D maps (Rhythmia) in patients with paroxysmal AF
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Lackermair, K, primary, Kellner, S, additional, Riesinger, L, additional, Rizas, K, additional, Sinner, M F, additional, Fichtner, S, additional, and Estner, H L, additional
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- 2018
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- View/download PDF
19. Genetic loci associated with heart rate variability and their effects on cardiac disease risk
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Nolte, I. M. (Ilja M.), Munoz, M. L. (M. Loretto), Tragante, V. (Vinicius), Amare, A. T. (Azmeraw T.), Jansen, R. (Rick), Vaez, A. (Ahmad), von der Heyde, B. (Benedikt), Avery, C. L. (Christy L.), Bis, J. C. (Joshua C.), Dierckx, B. (Bram), van Dongen, J. (Jenny), Gogarten, S. M. (Stephanie M.), Goyette, P. (Philippe), Hernesniemi, J. (Jussi), Huikari, V. (Ville), Hwang, S.-J. (Shih-Jen), Jaju, D. (Deepali), Kerr, K. F. (Kathleen F.), Kluttig, A. (Alexander), Krijthe, B. P. (Bouwe P.), Kumar, J. (Jitender), van der Laan, S. W. (Sander W.), Lyytikäinen, L.-P. (Leo-Pekka), Maihofer, A. X. (Adam X.), Minassian, A. (Arpi), van der Most, P. J. (Peter J.), Mueller-Nurasyid, M. (Martina), Nivard, M. (Michel), Salvi, E. (Erika), Stewart, J. D. (James D.), Thayer, J. F. (Julian F.), Verweij, N. (Niek), Wong, A. (Andrew), Zabaneh, D. (Delilah), Zafarmand, M. H. (Mohammad H.), Abdellaoui, A. (Abdel), Albarwani, S. (Sulayma), Albert, C. (Christine), Alonso, A. (Alvaro), Ashar, F. (Foram), Auvinen, J. (Juha), Axelsson, T. (Tomas), Baker, D. G. (Dewleen G.), de Bakker, P. I. (Paul I. W.), Barcella, M. (Matteo), Bayoumi, R. (Riad), Bieringa, R. J. (Rob J.), Boomsma, D. (Dorret), Boucher, G. (Gabrielle), Britton, A. R. (Annie R.), Christophersen, I. E. (Ingrid E.), Dietrich, A. (Andrea), Ehret, G. B. (George B.), Ellinor, P. T. (Patrick T.), Eskola, M. (Markku), Felix, J. F. (Janine F.), Floras, J. S. (John S.), Franco, O. H. (Oscar H.), Friberg, P. (Peter), Gademan, M. G. (Maaike G. J.), Geyer, M. A. (Mark A.), Giedraitis, V. (Vilmantas), Hartman, C. A. (Catharina A.), Hemerich, D. (Daiane), Hofman, A. (Albert), Hottenga, J.-J. (Jouke-Jan), Huikuri, H. (Heikki), Hutri-Kähönen, N. (Nina), Jouven, X. (Xavier), Junttila, J. (Juhani), Juonala, M. (Markus), Kiviniemi, A. M. (Antti M.), Kors, J. A. (Jan A.), Kumari, M. (Meena), Kuznetsova, T. (Tatiana), Laurie, C. C. (Cathy C.), Lefrandt, J. D. (Joop D.), Li, Y. (Yong), Li, Y. (Yun), Liao, D. (Duanping), Limacher, M. C. (Marian C.), Lin, H. J. (Henry J.), Lindgren, C. M. (Cecilia M.), Lubitz, S. A. (Steven A.), Mahajan, A. (Anubha), McKnight, B. (Barbara), zu Schwabedissen, H. M. (Henriette Meyer), Milaneschi, Y. (Yuri), Mononen, N. (Nina), Morris, A. P. (Andrew P.), Nalls, M. A. (Mike A.), Navis, G. (Gerjan), Neijts, M. (Melanie), Nikus, K. (Kjell), North, K. E. (Kari E.), O'Connor, D. T. (Daniel T.), Ormel, J. (Johan), Perz, S. (Siegfried), Peters, A. (Annette), Psaty, B. M. (Bruce M.), Raitakari, O. T. (Olli T.), Risbrough, V. B. (Victoria B.), Sinner, M. F. (Moritz F.), Siscovick, D. (David), Smit, J. H. (Johannes H.), Smith, N. L. (Nicholas L.), Soliman, E. Z. (Elsayed Z.), Sotoodehnia, N. (Nona), Staessen, J. A. (Jan A.), Stein, P. K. (Phyllis K.), Stilp, A. M. (Adrienne M.), Stolarz-Skrzypek, K. (Katarzyna), Strauch, K. (Konstantin), Sundström, J. (Johan), Swenne, C. A. (Cees A.), Syvänen, A.-C. (Ann-Christine), Tardif, J.-C. (Jean-Claude), Taylor, K. D. (Kent D.), Teumer, A. (Alexander), Thornton, T. A. (Timothy A.), Tinker, L. E. (Lesley E.), Uitterlinden, A. G. (Andre G.), van Setten, J. (Jessica), Voss, A. (Andreas), Waldenberger, M. (Melanie), Wilhelmsen, K. C. (Kirk C.), Willemsen, G. (Gonneke), Wong, Q. (Quenna), Zhang, Z.-M. (Zhu-Ming), Zonderman, A. B. (Alan B.), Cusi, D. (Daniele), Evans, M. K. (Michele K.), Greiser, H. K. (Halina K.), van der Harst, P. (Pim), Hassan, M. (Mohammad), Ingelsson, E. (Erik), Järvelin, M.-R. (Marjo-Riitta), Kaab, S. (Stefan), Kähönen, M. (Mika), Kivimäki, M. (Mika), Kooperberg, C. (Charles), Kuh, D. (Diana), Lehtimäki, T. (Terho), Lind, L. (Lars), Nievergelt, C. M. (Caroline M.), O'Donnell, C. J. (Chris J.), Oldehinkel, A. J. (Albertine J.), Penninx, B. (Brenda), Reiner, A. P. (Alexander P.), Riese, H. (Harriette), van Roon, A. M. (Arie M.), Rioux, J. D. (John D.), Rotter, J. I. (Jerome I.), Sofer, T. (Tamar), Stricker, B. H. (Bruno H.), Tiemeier, H. (Henning), Vrijkotte, T. G. (Tanja G. M.), Asselbergs, F. W. (Folkert W.), Brundel, B. J. (Bianca J. J. M.), Heckbert, S. R. (Susan R.), Whitsel, E. A. (Eric A.), den Hoed, M. (Marcel), Snieder, H. (Harold), de Geus, E. J. (Eco J. C.), Nolte, I. M. (Ilja M.), Munoz, M. L. (M. Loretto), Tragante, V. (Vinicius), Amare, A. T. (Azmeraw T.), Jansen, R. (Rick), Vaez, A. (Ahmad), von der Heyde, B. (Benedikt), Avery, C. L. (Christy L.), Bis, J. C. (Joshua C.), Dierckx, B. (Bram), van Dongen, J. (Jenny), Gogarten, S. M. (Stephanie M.), Goyette, P. (Philippe), Hernesniemi, J. (Jussi), Huikari, V. (Ville), Hwang, S.-J. (Shih-Jen), Jaju, D. (Deepali), Kerr, K. F. (Kathleen F.), Kluttig, A. (Alexander), Krijthe, B. P. (Bouwe P.), Kumar, J. (Jitender), van der Laan, S. W. (Sander W.), Lyytikäinen, L.-P. (Leo-Pekka), Maihofer, A. X. (Adam X.), Minassian, A. (Arpi), van der Most, P. J. (Peter J.), Mueller-Nurasyid, M. (Martina), Nivard, M. (Michel), Salvi, E. (Erika), Stewart, J. D. (James D.), Thayer, J. F. (Julian F.), Verweij, N. (Niek), Wong, A. (Andrew), Zabaneh, D. (Delilah), Zafarmand, M. H. (Mohammad H.), Abdellaoui, A. (Abdel), Albarwani, S. (Sulayma), Albert, C. (Christine), Alonso, A. (Alvaro), Ashar, F. (Foram), Auvinen, J. (Juha), Axelsson, T. (Tomas), Baker, D. G. (Dewleen G.), de Bakker, P. I. (Paul I. W.), Barcella, M. (Matteo), Bayoumi, R. (Riad), Bieringa, R. J. (Rob J.), Boomsma, D. (Dorret), Boucher, G. (Gabrielle), Britton, A. R. (Annie R.), Christophersen, I. E. (Ingrid E.), Dietrich, A. (Andrea), Ehret, G. B. (George B.), Ellinor, P. T. (Patrick T.), Eskola, M. (Markku), Felix, J. F. (Janine F.), Floras, J. S. (John S.), Franco, O. H. (Oscar H.), Friberg, P. (Peter), Gademan, M. G. (Maaike G. J.), Geyer, M. A. (Mark A.), Giedraitis, V. (Vilmantas), Hartman, C. A. (Catharina A.), Hemerich, D. (Daiane), Hofman, A. (Albert), Hottenga, J.-J. (Jouke-Jan), Huikuri, H. (Heikki), Hutri-Kähönen, N. (Nina), Jouven, X. (Xavier), Junttila, J. (Juhani), Juonala, M. (Markus), Kiviniemi, A. M. (Antti M.), Kors, J. A. (Jan A.), Kumari, M. (Meena), Kuznetsova, T. (Tatiana), Laurie, C. C. (Cathy C.), Lefrandt, J. D. (Joop D.), Li, Y. (Yong), Li, Y. (Yun), Liao, D. (Duanping), Limacher, M. C. (Marian C.), Lin, H. J. (Henry J.), Lindgren, C. M. (Cecilia M.), Lubitz, S. A. (Steven A.), Mahajan, A. (Anubha), McKnight, B. (Barbara), zu Schwabedissen, H. M. (Henriette Meyer), Milaneschi, Y. (Yuri), Mononen, N. (Nina), Morris, A. P. (Andrew P.), Nalls, M. A. (Mike A.), Navis, G. (Gerjan), Neijts, M. (Melanie), Nikus, K. (Kjell), North, K. E. (Kari E.), O'Connor, D. T. (Daniel T.), Ormel, J. (Johan), Perz, S. (Siegfried), Peters, A. (Annette), Psaty, B. M. (Bruce M.), Raitakari, O. T. (Olli T.), Risbrough, V. B. (Victoria B.), Sinner, M. F. (Moritz F.), Siscovick, D. (David), Smit, J. H. (Johannes H.), Smith, N. L. (Nicholas L.), Soliman, E. Z. (Elsayed Z.), Sotoodehnia, N. (Nona), Staessen, J. A. (Jan A.), Stein, P. K. (Phyllis K.), Stilp, A. M. (Adrienne M.), Stolarz-Skrzypek, K. (Katarzyna), Strauch, K. (Konstantin), Sundström, J. (Johan), Swenne, C. A. (Cees A.), Syvänen, A.-C. (Ann-Christine), Tardif, J.-C. (Jean-Claude), Taylor, K. D. (Kent D.), Teumer, A. (Alexander), Thornton, T. A. (Timothy A.), Tinker, L. E. (Lesley E.), Uitterlinden, A. G. (Andre G.), van Setten, J. (Jessica), Voss, A. (Andreas), Waldenberger, M. (Melanie), Wilhelmsen, K. C. (Kirk C.), Willemsen, G. (Gonneke), Wong, Q. (Quenna), Zhang, Z.-M. (Zhu-Ming), Zonderman, A. B. (Alan B.), Cusi, D. (Daniele), Evans, M. K. (Michele K.), Greiser, H. K. (Halina K.), van der Harst, P. (Pim), Hassan, M. (Mohammad), Ingelsson, E. (Erik), Järvelin, M.-R. (Marjo-Riitta), Kaab, S. (Stefan), Kähönen, M. (Mika), Kivimäki, M. (Mika), Kooperberg, C. (Charles), Kuh, D. (Diana), Lehtimäki, T. (Terho), Lind, L. (Lars), Nievergelt, C. M. (Caroline M.), O'Donnell, C. J. (Chris J.), Oldehinkel, A. J. (Albertine J.), Penninx, B. (Brenda), Reiner, A. P. (Alexander P.), Riese, H. (Harriette), van Roon, A. M. (Arie M.), Rioux, J. D. (John D.), Rotter, J. I. (Jerome I.), Sofer, T. (Tamar), Stricker, B. H. (Bruno H.), Tiemeier, H. (Henning), Vrijkotte, T. G. (Tanja G. M.), Asselbergs, F. W. (Folkert W.), Brundel, B. J. (Bianca J. J. M.), Heckbert, S. R. (Susan R.), Whitsel, E. A. (Eric A.), den Hoed, M. (Marcel), Snieder, H. (Harold), and de Geus, E. J. (Eco J. C.)
- Abstract
Reduced cardiac vagal control reflected in low heart rate variability (HRV) is associated with greater risks for cardiac morbidity and mortality. In two-stage meta-analyses of genome-wide association studies for three HRV traits in up to 53,174 individuals of European ancestry, we detect 17 genome-wide significant SNPs in eight loci. HRV SNPs tag non-synonymous SNPs (in NDUFA11 and KIAA1755), expression quantitative trait loci (eQTLs) (influencing GNG11, RGS6 and NEO1), or are located in genes preferentially expressed in the sinoatrial node (GNG11, RGS6 and HCN4). Genetic risk scores account for 0.9 to 2.6% of the HRV variance. Significant genetic correlation is found for HRV with heart rate (-0.74
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- 2017
20. Screening for Atrial Fibrillation
- Author
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Freedman, Ben, primary, Camm, John, additional, Calkins, Hugh, additional, Healey, Jeffrey S., additional, Rosenqvist, Mårten, additional, Wang, Jiguang, additional, Albert, Christine M., additional, Anderson, Craig S., additional, Antoniou, Sotiris, additional, Benjamin, Emelia J., additional, Boriani, Giuseppe, additional, Brachmann, Johannes, additional, Brandes, Axel, additional, Chao, Tze-Fan, additional, Conen, David, additional, Engdahl, Johan, additional, Fauchier, Laurent, additional, Fitzmaurice, David A., additional, Friberg, Leif, additional, Gersh, Bernard J., additional, Gladstone, David J., additional, Glotzer, Taya V., additional, Gwynne, Kylie, additional, Hankey, Graeme J., additional, Harbison, Joseph, additional, Hillis, Graham S., additional, Hills, Mellanie T., additional, Kamel, Hooman, additional, Kirchhof, Paulus, additional, Kowey, Peter R., additional, Krieger, Derk, additional, Lee, Vivian W. Y., additional, Levin, Lars-Åke, additional, Lip, Gregory Y. H., additional, Lobban, Trudie, additional, Lowres, Nicole, additional, Mairesse, Georges H., additional, Martinez, Carlos, additional, Neubeck, Lis, additional, Orchard, Jessica, additional, Piccini, Jonathan P., additional, Poppe, Katrina, additional, Potpara, Tatjana S., additional, Puererfellner, Helmut, additional, Rienstra, Michiel, additional, Sandhu, Roopinder K., additional, Schnabel, Renate B., additional, Siu, Chung-Wah, additional, Steinhubl, Steven, additional, Svendsen, Jesper H., additional, Svennberg, Emma, additional, Themistoclakis, Sakis, additional, Tieleman, Robert G., additional, Turakhia, Mintu P., additional, Tveit, Arnljot, additional, Uittenbogaart, Steven B., additional, Van Gelder, Isabelle C., additional, Verma, Atul, additional, Wachter, Rolf, additional, Yan, Bryan P., additional, Al Awwad, A, additional, Al-Kalili, F, additional, Berge, T, additional, Breithardt, G, additional, Bury, G, additional, Caorsi, WR, additional, Chan, NY, additional, Chen, SA, additional, Christophersen, I, additional, Connolly, S, additional, Crijns, H, additional, Davis, S, additional, Dixen, U, additional, Doughty, R, additional, Du, X, additional, Ezekowitz, M, additional, Fay, M, additional, Frykman, V, additional, Geanta, M, additional, Gray, H, additional, Grubb, N, additional, Guerra, A, additional, Halcox, J, additional, Hatala, R, additional, Heidbuchel, H, additional, Jackson, R, additional, Johnson, L, additional, Kaab, S, additional, Keane, K, additional, Kim, YH, additional, Kollios, G, additional, Løchen, ML, additional, Ma, C, additional, Mant, J, additional, Martinek, M, additional, Marzona, I, additional, Matsumoto, K, additional, McManus, D, additional, Moran, P, additional, Naik, N, additional, Ngarmukos, T, additional, Prabhakaran, D, additional, Reidpath, D, additional, Ribeiro, A, additional, Rudd, A, additional, Savalieva, I, additional, Schilling, R, additional, Sinner, M, additional, Stewart, S, additional, Suwanwela, N, additional, Takahashi, N, additional, Topol, E, additional, Ushiyama, S, additional, Verbiest van Gurp, N, additional, Walker, N, additional, and Wijeratne, T, additional
- Published
- 2017
- Full Text
- View/download PDF
21. Patents and literature
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Rembaum, A., Rohrbach, R. P., Klose, S., Batz, H. G., Stoltz, M., Hagen, A., Weimann, G., Wildman, S. G., Kwanyuen, P., Franzmann, G., Wulsmann, H. L., Nakanishi, T., Shigemasa, Y., Monsheimer, R., Pfleiderer, E., Yoshioka, T., Teramoto, K., Shimamura, M., Lee, C. K., Tamuri, M., Kanno, M., Ishi, Y., Kaetsu, I., Kumakura, M., Yoshida, M., Strobel, G. A., Johnson, D. E., Srinivasan, V. R., Choi, Y. C., Fukuda, H., Shiotani, T., Okada, W., Messing, R. A., Oppermann, R. A., Simpson, L. B., Takeguchi, M. M., Bigazzi, M., Higerd, T. B., Goust, J. M. C., Tolbert, W. R., Kuo, M. J., Feder, J., Patel, R. N., Hou, C. T., Laskin, A. I., Yukawa, H., Osumi, K., Takayama, Y., Fujiwara, A., Masuda, S., Takaku, F., Ogasa, K., Kuboyama, M., Saito, M., Yanai, N., Nishida, M., Tosaka, O., Ono, E., Ishihara, M., Morioka, H., Takinami, K., Taoka, A., Uchida, S., Puls, J., Sinner, M., Dietrichs, H. H., Wicklow, D. T., Detroy, R. W., Heady, R. E., Yukawa, H., Osumi, K., Nara, T., Takayama, Y., Knight, E., Tsao, G. T., Ladisch, M. R., Ladisch, C. M., Hsu, T. A., Friesen, H. J., Pestka, S., Manis, J. J., Debabov, V. G., Kozlov, J. I., Zhdanova, N. I., Khurges, E. M., Yankovsky, N. K., Rozinov, M. R., Shakulov, R. S., Rebentish, B. A., Livshits, V. A., Gusyatiner, M. M., Mashko, S. V., Moshentseva, V. N., Kozyreva, L. F., Arsatiants, R. A., Goodman, H. M., Shine, J., Horst, P., Goeddel, D. V., and Heyneker, H. L.
- Published
- 1981
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- View/download PDF
22. Automated quantitative analysis of wood carbohydrates by borate complex ion exchange chromatography
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Sinner, M., Simatupang, M. H., and Dietrichs, H. H.
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- 1975
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- View/download PDF
23. Enzymatischer Abbau von Xylan in Rotbuchenholocellulose
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Sinner, M. and Dietrichs, H. H.
- Published
- 1976
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- View/download PDF
24. Topochemical studies on the wall of beech bark sclereids by enzymatic and acidic degradation
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Parameswaran, N. and Sinner, M.
- Published
- 1979
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- View/download PDF
25. Simple Risk Model Predicts Incidence of Atrial Fibrillation in a Racially and Geographically Diverse Population: the CHARGE-AF Consortium
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Couper, D., Ellinor, P. T., Alonso, A., Burke, G. L., Gudnason, V., Magnani, J. W., Heckbert, S. R., Schnabel, R. B., Larson, M. G., Harris, T. B., Soliman, E. Z., Witteman, J. C., Stepas, K. A., Moser, C. B., Sinner, M. F., Launer, L. J., Pencina, M. J., Sotoodehnia, N., Kaab, S., Levy, D., Stricker, B. H. C., Hofman, A., Fontes, J. D., Krijthe, B. P., Lubitz, S. A., Gottdiener, J. S., Agarwal, S. K., Kronmal, R. A., Chamberlain, A. M., McManus, D. D., Aspelund, T., and Janssens, A. C. J. W.
- Abstract
BackgroundTools for the prediction of atrial fibrillation (AF) may identify high‐risk individuals more likely to benefit from preventive interventions and serve as a benchmark to test novel putative risk factors.Methods and ResultsIndividual‐level data from 3 large cohorts in the United States (Atherosclerosis Risk in Communities [ARIC] study, the Cardiovascular Health Study [CHS], and the Framingham Heart Study [FHS]), including 18 556 men and women aged 46 to 94 years (19% African Americans, 81% whites) were pooled to derive predictive models for AF using clinical variables. Validation of the derived models was performed in 7672 participants from the Age, Gene and Environment—Reykjavik study (AGES) and the Rotterdam Study (RS). The analysis included 1186 incident AF cases in the derivation cohorts and 585 in the validation cohorts. A simple 5‐year predictive model including the variables age, race, height, weight, systolic and diastolic blood pressure, current smoking, use of antihypertensive medication, diabetes, and history of myocardial infarction and heart failure had good discrimination (C‐statistic, 0.765; 95% CI, 0.748 to 0.781). Addition of variables from the electrocardiogram did not improve the overall model discrimination (C‐statistic, 0.767; 95% CI, 0.750 to 0.783; categorical net reclassification improvement, −0.0032; 95% CI, −0.0178 to 0.0113). In the validation cohorts, discrimination was acceptable (AGES C‐statistic, 0.664; 95% CI, 0.632 to 0.697 and RS C‐statistic, 0.705; 95% CI, 0.664 to 0.747) and calibration was adequate.ConclusionA risk model including variables readily available in primary care settings adequately predicted AF in diverse populations from the United States and Europe.
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- 2013
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26. Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization
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Arking, D, Pulit, S, Crotti, L, van der Harst, P, Munroe, P, Koopmann, T, Sotoodehnia, N, Rossin, E, Morley, M, Wang, X, Johnson, A, Lundby, A, Gudbjartsson, D, Noseworthy, P, Eijgelsheim, M, Bradford, Y, Tarasov, K, Dörr, M, Müller-Nurasyid, M, Lahtinen, A, Nolte, I, Smith, A, Bis, J, Isaacs, A, Newhouse, S, Evans, D, Post, W, Waggott, D, Lyytikäinen, L, Hicks, A, Eisele, L, Ellinghaus, D, Hayward, C, Navarro, P, Ulivi, S, Tanaka, T, Tester, D, Chatel, S, Gustafsson, S, Kumari, M, Morris, R, Naluai, A, Padmanabhan, S, Kluttig, A, Strohmer, B, Panayiotou, A, Torres, M, Knoflach, M, Hubacek, J, Slowikowski, K, Raychaudhuri, S, Kumar, R, Harris, T, Launer, L, Shuldiner, A, Alonso, A, Bader, J, Ehret, G, Huang, H, Kao, W, Strait, J, Macfarlane, P, Brown, M, Caulfield, M, Samani, N, Kronenberg, F, Willeit, J, Smith, J, Greiser, K, Meyer Zu Schwabedissen, H, Werdan, K, Carella, M, Zelante, L, Heckbert, S, Psaty, B, Rotter, J, Kolcic, I, Polašek, O, Wright, A, Griffin, M, Daly, M, Arnar, D, Hólm, H, Thorsteinsdottir, U, Denny, J, Roden, D, Zuvich, R, Emilsson, V, Plump, A, Larson, M, O'Donnell, C, Yin, X, Bobbo, M, D'Adamo, A, Iorio, A, Sinagra, G, Carracedo, A, Cummings, S, Nalls, M, Jula, A, Kontula, K, Marjamaa, A, Oikarinen, L, Perola, M, Porthan, K, Erbel, R, Hoffmann, P, Jöckel, K, Kälsch, H, Nöthen, M, den Hoed, M, Loos, R, Thelle, D, Gieger, C, Meitinger, T, Perz, S, Peters, A, Prucha, H, Sinner, M, Waldenberger, M, de Boer, R, Franke, L, van der Vleuten, P, Beckmann, B, Martens, E, Bardai, A, Hofman, N, Wilde, A, Behr, E, Dalageorgou, C, Giudicessi, J, Medeiros-Domingo, A, Kyndt, F, Probst, V, Ghidoni, A, Insolia, R, Hamilton, R, Scherer, S, Brandimarto, J, Margulies, K, Moravec, C, Greco, M, Fuchsberger, C, O'Connell, J, Lee, W, Watt, G, Campbell, H, Wild, S, El Mokhtari, N, Frey, N, Asselbergs, F, Mateo Leach, I, Navis, G, van den Berg, M, van Veldhuisen, D, Kellis, M, Krijthe, B, Franco, O, Hofman, A, Kors, J, Uitterlinden, A, Witteman, J, Kedenko, L, Lamina, C, Oostra, B, Abecasis, G, Lakatta, E, Mulas, A, Orrú, M, Schlessinger, D, Uda, M, Markus, M, Völker, U, Snieder, H, Spector, T, Arnlöv, J, Lind, L, Sundström, J, Syvänen, A, Kivimaki, M, Kähönen, M, Mononen, N, Raitakari, O, Viikari, J, Adamkova, V, Kiechl, S, Brion, M, Nicolaides, A, Paulweber, B, Haerting, J, Dominiczak, A, Nyberg, F, Whincup, P, Hingorani, A, Schott, J, Bezzina, C, Ingelsson, E, Ferrucci, L, Gasparini, P, Wilson, J, Rudan, I, Franke, A, Mühleisen, T, Pramstaller, P, Lehtimäki, T, Paterson, A, Parsa, A, Liu, Y, van Duijn, C, Siscovick, D, Gudnason, V, Jamshidi, Y, Salomaa, V, Felix, S, Sanna, S, Ritchie, M, Stricker, B, Stefansson, K, Boyer, L, Cappola, T, Olsen, J, Lage, K, Schwartz, P, Kääb, S, Chakravarti, A, Ackerman, M, Pfeufer, A, de Bakker, P, Newton-Cheh, C, Arking, DE, Pulit, SL, Munroe, PB, Rossin, EJ, Johnson, AD, Gudbjartsson, DF, Noseworthy, PA, Tarasov, KV, Lahtinen, AM, Nolte, IM, Smith, AV, Bis, JC, Newhouse, SJ, Evans, DS, Post, WS, Lyytikäinen, LP, Hicks, AA, Tester, DJ, Morris, RW, Naluai, AT, Panayiotou, AG, Hubacek, JA, Kumar, RD, Harris, TB, Launer, LJ, Shuldiner, AR, Bader, JS, Kao, WH, Strait, JB, Macfarlane, PW, Caulfield, MJ, Samani, NJ, Smith, JG, Greiser, KH, Heckbert, SR, Psaty, BM, Rotter, JI, Wright, AF, Daly, MJ, Arnar, DO, Denny, JC, Roden, DM, Zuvich, RL, Plump, AS, Larson, MG, O'Donnell, CJ, D'Adamo, AP, Cummings, SR, Nalls, MA, Kontula, KK, Jöckel, KH, Nöthen, MM, Loos, RJ, Thelle, DS, Sinner, MF, de Boer, RA, van der Vleuten, PA, Beckmann, BM, Wilde, AA, Behr, ER, Giudicessi, JR, Hamilton, RM, Scherer, SW, Moravec, CE, Greco, MFD, O'Connell, JR, Lee, WK, Watt, GC, Wild, SH, El Mokhtari, NE, Asselbergs, FW, van den Berg, MP, van Veldhuisen, DJ, Krijthe, BP, Franco, OH, Kors, JA, Uitterlinden, AG, Witteman, JC, Oostra, BA, Abecasis, GR, Lakatta, EG, Markus, MR, Spector, TD, Syvänen, AC, Raitakari, OT, Viikari, JS, Nicolaides, AN, Dominiczak, AF, Whincup, PH, Hingorani, AD, Schott, JJ, Bezzina, CR, Wilson, JF, Mühleisen, TW, Pramstaller, PP, Lehtimäki, TJ, Paterson, AD, van Duijn, CM, Siscovick, DS, Felix, SB, Ritchie, MD, Stricker, BH, Boyer, LA, Cappola, TP, Olsen, JV, Schwartz, PJ, Ackerman, MJ, de Bakker, PI, Arking, D, Pulit, S, Crotti, L, van der Harst, P, Munroe, P, Koopmann, T, Sotoodehnia, N, Rossin, E, Morley, M, Wang, X, Johnson, A, Lundby, A, Gudbjartsson, D, Noseworthy, P, Eijgelsheim, M, Bradford, Y, Tarasov, K, Dörr, M, Müller-Nurasyid, M, Lahtinen, A, Nolte, I, Smith, A, Bis, J, Isaacs, A, Newhouse, S, Evans, D, Post, W, Waggott, D, Lyytikäinen, L, Hicks, A, Eisele, L, Ellinghaus, D, Hayward, C, Navarro, P, Ulivi, S, Tanaka, T, Tester, D, Chatel, S, Gustafsson, S, Kumari, M, Morris, R, Naluai, A, Padmanabhan, S, Kluttig, A, Strohmer, B, Panayiotou, A, Torres, M, Knoflach, M, Hubacek, J, Slowikowski, K, Raychaudhuri, S, Kumar, R, Harris, T, Launer, L, Shuldiner, A, Alonso, A, Bader, J, Ehret, G, Huang, H, Kao, W, Strait, J, Macfarlane, P, Brown, M, Caulfield, M, Samani, N, Kronenberg, F, Willeit, J, Smith, J, Greiser, K, Meyer Zu Schwabedissen, H, Werdan, K, Carella, M, Zelante, L, Heckbert, S, Psaty, B, Rotter, J, Kolcic, I, Polašek, O, Wright, A, Griffin, M, Daly, M, Arnar, D, Hólm, H, Thorsteinsdottir, U, Denny, J, Roden, D, Zuvich, R, Emilsson, V, Plump, A, Larson, M, O'Donnell, C, Yin, X, Bobbo, M, D'Adamo, A, Iorio, A, Sinagra, G, Carracedo, A, Cummings, S, Nalls, M, Jula, A, Kontula, K, Marjamaa, A, Oikarinen, L, Perola, M, Porthan, K, Erbel, R, Hoffmann, P, Jöckel, K, Kälsch, H, Nöthen, M, den Hoed, M, Loos, R, Thelle, D, Gieger, C, Meitinger, T, Perz, S, Peters, A, Prucha, H, Sinner, M, Waldenberger, M, de Boer, R, Franke, L, van der Vleuten, P, Beckmann, B, Martens, E, Bardai, A, Hofman, N, Wilde, A, Behr, E, Dalageorgou, C, Giudicessi, J, Medeiros-Domingo, A, Kyndt, F, Probst, V, Ghidoni, A, Insolia, R, Hamilton, R, Scherer, S, Brandimarto, J, Margulies, K, Moravec, C, Greco, M, Fuchsberger, C, O'Connell, J, Lee, W, Watt, G, Campbell, H, Wild, S, El Mokhtari, N, Frey, N, Asselbergs, F, Mateo Leach, I, Navis, G, van den Berg, M, van Veldhuisen, D, Kellis, M, Krijthe, B, Franco, O, Hofman, A, Kors, J, Uitterlinden, A, Witteman, J, Kedenko, L, Lamina, C, Oostra, B, Abecasis, G, Lakatta, E, Mulas, A, Orrú, M, Schlessinger, D, Uda, M, Markus, M, Völker, U, Snieder, H, Spector, T, Arnlöv, J, Lind, L, Sundström, J, Syvänen, A, Kivimaki, M, Kähönen, M, Mononen, N, Raitakari, O, Viikari, J, Adamkova, V, Kiechl, S, Brion, M, Nicolaides, A, Paulweber, B, Haerting, J, Dominiczak, A, Nyberg, F, Whincup, P, Hingorani, A, Schott, J, Bezzina, C, Ingelsson, E, Ferrucci, L, Gasparini, P, Wilson, J, Rudan, I, Franke, A, Mühleisen, T, Pramstaller, P, Lehtimäki, T, Paterson, A, Parsa, A, Liu, Y, van Duijn, C, Siscovick, D, Gudnason, V, Jamshidi, Y, Salomaa, V, Felix, S, Sanna, S, Ritchie, M, Stricker, B, Stefansson, K, Boyer, L, Cappola, T, Olsen, J, Lage, K, Schwartz, P, Kääb, S, Chakravarti, A, Ackerman, M, Pfeufer, A, de Bakker, P, Newton-Cheh, C, Arking, DE, Pulit, SL, Munroe, PB, Rossin, EJ, Johnson, AD, Gudbjartsson, DF, Noseworthy, PA, Tarasov, KV, Lahtinen, AM, Nolte, IM, Smith, AV, Bis, JC, Newhouse, SJ, Evans, DS, Post, WS, Lyytikäinen, LP, Hicks, AA, Tester, DJ, Morris, RW, Naluai, AT, Panayiotou, AG, Hubacek, JA, Kumar, RD, Harris, TB, Launer, LJ, Shuldiner, AR, Bader, JS, Kao, WH, Strait, JB, Macfarlane, PW, Caulfield, MJ, Samani, NJ, Smith, JG, Greiser, KH, Heckbert, SR, Psaty, BM, Rotter, JI, Wright, AF, Daly, MJ, Arnar, DO, Denny, JC, Roden, DM, Zuvich, RL, Plump, AS, Larson, MG, O'Donnell, CJ, D'Adamo, AP, Cummings, SR, Nalls, MA, Kontula, KK, Jöckel, KH, Nöthen, MM, Loos, RJ, Thelle, DS, Sinner, MF, de Boer, RA, van der Vleuten, PA, Beckmann, BM, Wilde, AA, Behr, ER, Giudicessi, JR, Hamilton, RM, Scherer, SW, Moravec, CE, Greco, MFD, O'Connell, JR, Lee, WK, Watt, GC, Wild, SH, El Mokhtari, NE, Asselbergs, FW, van den Berg, MP, van Veldhuisen, DJ, Krijthe, BP, Franco, OH, Kors, JA, Uitterlinden, AG, Witteman, JC, Oostra, BA, Abecasis, GR, Lakatta, EG, Markus, MR, Spector, TD, Syvänen, AC, Raitakari, OT, Viikari, JS, Nicolaides, AN, Dominiczak, AF, Whincup, PH, Hingorani, AD, Schott, JJ, Bezzina, CR, Wilson, JF, Mühleisen, TW, Pramstaller, PP, Lehtimäki, TJ, Paterson, AD, van Duijn, CM, Siscovick, DS, Felix, SB, Ritchie, MD, Stricker, BH, Boyer, LA, Cappola, TP, Olsen, JV, Schwartz, PJ, Ackerman, MJ, and de Bakker, PI
- Abstract
The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal mendelian long-QT syndrome (LQTS). Using a genome-wide association and replication study in up to 100,000 individuals, we identified 35 common variant loci associated with QT interval that collectively explain ∼8-10% of QT-interval variation and highlight the importance of calcium regulation in myocardial repolarization. Rare variant analysis of 6 new QT interval-associated loci in 298 unrelated probands with LQTS identified coding variants not found in controls but of uncertain causality and therefore requiring validation. Several newly identified loci encode proteins that physically interact with other recognized repolarization proteins. Our integration of common variant association, expression and orthogonal protein-protein interaction screens provides new insights into cardiac electrophysiology and identifies new candidate genes for ventricular arrhythmias, LQTS and SCD
- Published
- 2014
27. Degradation of Delignified Sprucewood by Purified Mannanase, Xylanase, and Cellulases
- Author
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SINNER, M., primary, PARAMESWARAN, N., additional, and DIETRICHS, H. H., additional
- Published
- 1979
- Full Text
- View/download PDF
28. Incidence of sudden cardiac death in Germany: results from an emergency medical service registry in Lower Saxony
- Author
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Martens, E., primary, Sinner, M. F., additional, Siebermair, J., additional, Raufhake, C., additional, Beckmann, B. M., additional, Veith, S., additional, Duvel, D., additional, Steinbeck, G., additional, and Kaab, S., additional
- Published
- 2014
- Full Text
- View/download PDF
29. Clinical course of atrial fibrillation in older adults: the importance of cardiovascular events beyond stroke
- Author
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Piccini, J. P., primary, Hammill, B. G., additional, Sinner, M. F., additional, Hernandez, A. F., additional, Walkey, A. J., additional, Benjamin, E. J., additional, Curtis, L. H., additional, and Heckbert, S. R., additional
- Published
- 2013
- Full Text
- View/download PDF
30. Genome-wide association studies of atrial fibrillation: past, present, and future
- Author
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Sinner, M. F., primary, Ellinor, P. T., additional, Meitinger, T., additional, Benjamin, E. J., additional, and Kaab, S., additional
- Published
- 2011
- Full Text
- View/download PDF
31. Zur Verdaulichkeit von Stroh und Holz nach Aufschluß mit gesättigtem Wasserdampf bei höheren Temperaturen sowie Extraktion mit Wasser und verdünnter Natronlauge
- Author
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Kaufmann, W., primary, Sinner, M., additional, and Dietrichs, H. H., additional
- Published
- 2009
- Full Text
- View/download PDF
32. Spontaneous Brugada electrocardiogram patterns are rare in the German general population: results from the KORA study
- Author
-
Sinner, M. F., primary, Pfeufer, A., additional, Perz, S., additional, Schulze-Bahr, E., additional, Monnig, G., additional, Eckardt, L., additional, Beckmann, B.-M., additional, Wichmann, H.-E., additional, Breithardt, G., additional, Steinbeck, G., additional, Fabritz, L., additional, Kaab, S., additional, and Kirchhof, P., additional
- Published
- 2009
- Full Text
- View/download PDF
33. Large scale replication and meta-analysis of variants on chromosome 4q25 associated with atrial fibrillation
- Author
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Kaab, S., primary, Darbar, D., additional, van Noord, C., additional, Dupuis, J., additional, Pfeufer, A., additional, Newton-Cheh, C., additional, Schnabel, R., additional, Makino, S., additional, Sinner, M. F., additional, Kannankeril, P. J., additional, Beckmann, B. M., additional, Choudry, S., additional, Donahue, B. S., additional, Heeringa, J., additional, Perz, S., additional, Lunetta, K. L., additional, Larson, M. G., additional, Levy, D., additional, MacRae, C. A., additional, Ruskin, J. N., additional, Wacker, A., additional, Schomig, A., additional, Wichmann, H.-E., additional, Steinbeck, G., additional, Meitinger, T., additional, Uitterlinden, A. G., additional, Witteman, J. C.M., additional, Roden, D. M., additional, Benjamin, E. J., additional, and Ellinor, P. T., additional
- Published
- 2008
- Full Text
- View/download PDF
34. The common non-synonymous variant G38S of the KCNE1-(minK)-gene is not associated to QT interval in Central European Caucasians: results from the KORA study
- Author
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Akyol, M., primary, Jalilzadeh, S., additional, Sinner, M. F., additional, Perz, S., additional, Beckmann, B. M., additional, Gieger, C., additional, Illig, T., additional, Wichmann, H.-E., additional, Meitinger, T., additional, Kaab, S., additional, and Pfeufer, A., additional
- Published
- 2007
- Full Text
- View/download PDF
35. Production of high level of cellulase-free and thermostable xylanase by a wild strain of Thermomyces lanuginosus using beechwood xylan
- Author
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Gomes, J., primary, Gomes, I., additional, Kreiner, W., additional, Esterbauer, H., additional, Sinner, M., additional, and Steiner, W., additional
- Published
- 1993
- Full Text
- View/download PDF
36. Trägergebundene xylanolytische Enzyme. I. Wirkungsweise xylanolytischer Enzyme.
- Author
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Puls, J., Sinner, M., and Dietrichs, H. H.
- Published
- 1978
- Full Text
- View/download PDF
37. Zur Verdaulichkeit von Stroh und Holz nach Aufschluß mit gesättigtem Wasserdampf bei höheren Temperaturen sowie Extraktion mit Wasser und verdünnter Natronlauge.
- Author
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Kaufmann, W., Sinner, M., and Dietrichs, H. H.
- Published
- 1978
- Full Text
- View/download PDF
38. Concurrent Yield of Mycelium and Xylanolytic Enzymes from Extracts of Steamed Birchwood, Oat Husks and Wheat Straw.
- Author
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Schmidt, O., Puls, J., Sinner, M., and Dietrichs, H. H.
- Published
- 1979
39. Potential of Steaming Hardwoods and Straw for Feed and Food Production.
- Author
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Dietrichs, H. H., Sinner, M., and Puls, J.
- Published
- 1978
40. Untersuchungen über die Kohlenhydrate der Rinden einheimischer Holzarten.
- Author
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Dietrichs, H. H., Garves, K., Behrensdorf, D., and Sinner, M.
- Published
- 1978
41. Isolierung und Eigenschaften einer β-1,4-Mannanase aus Aspergillus niger.
- Author
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Yamazaki, N., Sinner, M., and Dietrichs, H. H.
- Published
- 1976
42. Enzymatische Hydrolyse von Laubholzxylanen.
- Author
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Sinner, M. and Dietrichs, H. H.
- Published
- 1976
43. Enzymatische Hydrolyse von Laubholzxylanen.
- Author
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Sinner, M. and Dietrichs, H. H.
- Published
- 1975
44. Untersuchungen über trägergebundene Xylanasen.
- Author
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Puls, J., Sinner, M., and Dietrichs, H. H.
- Published
- 1974
45. Spezifischer xylanolytischer Abbau der delignifizierten Zellwand von Rotbuchenholz (Fagus sylvatica L.).
- Author
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Sinner, M., Parameswaran, N., Dietrichs, H. H., and Liese, W.
- Published
- 1973
46. Chromatographische Trennung und Nachweis der enzymatischen Spaltprodukte des 4-O-Methylglucurono-xylans des Rotbuchenholzes (Fagus sylvatica L.).
- Author
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Sinner, M., Dietrichs, H. H., and Simatupang, M. H.
- Published
- 1972
47. Using outcome data and patient satisfaction surveys to develop policies regarding minimum length of hospitalization after radical prostatectomy
- Author
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Kirsh, E. J., Worwag, E. M., Sinner, M., and Chodak, G. W.
- Published
- 2000
- Full Text
- View/download PDF
48. Screening for Atrial Fibrillation
- Author
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Freedman, Ben, Camm, John, Calkins, Hugh, Healey, Jeffrey S., Rosenqvist, Mårten, Wang, Jiguang, Albert, Christine M., Anderson, Craig S., Antoniou, Sotiris, Benjamin, Emelia J., Boriani, Giuseppe, Brachmann, Johannes, Brandes, Axel, Chao, Tze-Fan, Conen, David, Engdahl, Johan, Fauchier, Laurent, Fitzmaurice, David A., Friberg, Leif, Gersh, Bernard J., Gladstone, David J., Glotzer, Taya V., Gwynne, Kylie, Hankey, Graeme J., Harbison, Joseph, Hillis, Graham S., Hills, Mellanie T., Kamel, Hooman, Kirchhof, Paulus, Kowey, Peter R., Krieger, Derk, Lee, Vivian W. Y., Levin, Lars-Åke, Lip, Gregory Y. H., Lobban, Trudie, Lowres, Nicole, Mairesse, Georges H., Martinez, Carlos, Neubeck, Lis, Orchard, Jessica, Piccini, Jonathan P., Poppe, Katrina, Potpara, Tatjana S., Puererfellner, Helmut, Rienstra, Michiel, Sandhu, Roopinder K., Schnabel, Renate B., Siu, Chung-Wah, Steinhubl, Steven, Svendsen, Jesper H., Svennberg, Emma, Themistoclakis, Sakis, Tieleman, Robert G., Turakhia, Mintu P., Tveit, Arnljot, Uittenbogaart, Steven B., Van Gelder, Isabelle C., Verma, Atul, Wachter, Rolf, Yan, Bryan P., Al Awwad, A, Al-Kalili, F, Berge, T, Breithardt, G, Bury, G, Caorsi, WR, Chan, NY, Chen, SA, Christophersen, I, Connolly, S, Crijns, H, Davis, S, Dixen, U, Doughty, R, Du, X, Ezekowitz, M, Fay, M, Frykman, V, Geanta, M, Gray, H, Grubb, N, Guerra, A, Halcox, J, Hatala, R, Heidbuchel, H, Jackson, R, Johnson, L, Kaab, S, Keane, K, Kim, YH, Kollios, G, Løchen, ML, Ma, C, Mant, J, Martinek, M, Marzona, I, Matsumoto, K, McManus, D, Moran, P, Naik, N, Ngarmukos, T, Prabhakaran, D, Reidpath, D, Ribeiro, A, Rudd, A, Savalieva, I, Schilling, R, Sinner, M, Stewart, S, Suwanwela, N, Takahashi, N, Topol, E, Ushiyama, S, Verbiest van Gurp, N, Walker, N, and Wijeratne, T
- Full Text
- View/download PDF
49. Isolierung und Eigenschaften einer ß-1,4-Mannanase aus Aspergillus niger
- Author
-
Yamazaki, N., Sinner, M., and Dietrichs, H. H.
- Published
- 1976
- Full Text
- View/download PDF
50. Carbohydrate Composition of Nut Shells and Some Other Agricultural Residues.
- Author
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Sinner, M., Puls, J., and Dietrichs, H.
- Published
- 1979
- Full Text
- View/download PDF
Catalog
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