1. Oral therapy adherence and satisfaction in patients with multiple myeloma.
- Author
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Solano, Marine, Daguindau, Etienne, Faure, Cyril, Loriod, Pierre, Pain, Coline, Maes, Anne-Cécile, Marguet, Pauline, Kroemer, Marie, Rumpler, Anne, Fontan, Jean, Deconinck, Eric, Limat, Samuel, and Clairet, Anne-Laure
- Subjects
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PATIENT compliance , *PATIENT satisfaction , *MULTIPLE myeloma , *UNIVARIATE analysis , *FACTOR analysis , *HOSPITAL statistics , *THERAPEUTIC use of antineoplastic agents , *RESEARCH , *FERRANS & Powers Quality of Life Index , *ACADEMIC medical centers , *SPECIALTY hospitals , *CROSS-sectional method , *ORAL drug administration , *RESEARCH methodology , *ANTINEOPLASTIC agents , *SATISFACTION , *MEDICAL cooperation , *EVALUATION research , *SOCIOECONOMIC factors , *COMPARATIVE studies , *DRUGS , *PSYCHOLOGY of caregivers , *QUESTIONNAIRES , *LONGITUDINAL method - Abstract
The transition to oral therapies in patients with multiple myeloma (MM) offers potential benefits to patients; however, they must self-manage their medication and adherence plays an important role in patient care. It has been shown that patient satisfaction with their medication has a strong positive correlation with adherence in chronic diseases. The aim of this study was to estimate adherence rate of oral antimyeloma therapies and to identify risk factors for medication non-adherence. This observational, prospective, and multicentre survey based on a self-report questionnaire enrolled MM patients with at least 3 months of oral therapy. The 6-item Girerd scale and the medication possession ratio (MPR) were used for measuring medication adherence and the SATMED-Q® questionnaire was used for measuring satisfaction. An analysis of risk factors for non-adherence to oral therapy was performed using univariate analysis. A total of 101 patients participated in the survey, yielding a response rate of 87%. The prevalence of adherence to oral antimyeloma therapy was estimated at 51.5% using the Girerd questionnaire. According to the MPR, adherence was evaluated at 96% (i.e. MPR ≥ 0.80). Both methods combined, adherence was estimated at 50.5%. One risk factor for medication non-adherence was identified: Eastern Cooperative Oncology Group Performance Status > 2 (p = 0.007). One predictive factor for high medication adherence was identified: high satisfaction with treatment (p = 0.01). Identifying patients at higher risk for non-adherence allows clinical pharmacists to personalise therapeutic information and education and to improve the quality of healthcare overall. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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