424 results on '"Song, Jinhua J."'
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2. Development of a Scalable Asymmetric Process for the Synthesis of Selective PDE4B Inhibitor Nerandomilast (BI 1015550).
3. Enhanced Ligand Discovery through Generative AI and Latent-Space Exploration: Application to the Mizoroki-Heck Reaction
4. Development of a Scalable Synthesis toward a KRAS G12C Inhibitor Building Block Bearing an All-Carbon Quaternary Stereocenter, Part 2: Asymmetric Synthesis via Shi Epoxidation
5. Development of a Scalable Synthesis toward a KRAS G12C Inhibitor Building Block Bearing an All-Carbon Quaternary Stereocenter, Part 1: From Discovery Route to Kilogram-Scale Production
6. Building a Quaternary Stereogenic Center on Dihydroazaindole Carboxylic Acid through Scalable Process Development
7. Feed-Forward Neural Network for Predicting Enantioselectivity of the Asymmetric Negishi Reaction
8. Synthesis of BI 894416 and BI 1342561, two potent and selective spleen tyrosine kinase inhibitors, labeled with carbon 14 and with deuterium
9. Synthesis of Beta‐Site Amyloid Precursor Protein‐Cleaving Enzyme 1 Inhibitors BI 1147560 and BI 1181181 Labeled with Carbon‐14 and Deuterium
10. Development of a Scalable Asymmetric Process for the Synthesis of GLYT1 Inhibitor BI 425809 (Iclepertin)
11. Process Development of the BACE Inhibitors BI 1147560 BS and BI 1181181 MZ
12. Carbon 14 synthesis of glycine transporter 1 inhibitor Iclepertin (BI 425809) and its major metabolites.
13. Scalable Process of Spiro(cyclopropane)oxazepane Pyridine Carboxylic Acid through Kulinkovich, Mitsunobu, and Pd-Catalyzed Intramolecular C–N Coupling
14. Development of an Asymmetric Route for Large-Scale Synthesis of a Glucocorticoid Agonist
15. Development of an Efficient Asymmetric Synthesis of the Chiral Quaternary 5-Lipoxygenase Activating Protein Inhibitor
16. Best Practices for Drug Substance Stress and Stability Studies During Early Stage Development. Part III—How to Make Science- and Risk-based Stability Testing Decisions for Drug Substance Batches Produced after Manufacturing Process Changes
17. Best Practices for Drug Substance Stress and Stability Studies During Early-Stage Development Part II—Conducting Abbreviated Long-Term and Accelerated Stability Testing on the First Clinical Drug Substance Batch to Confirm and Adjust the Drug Substance Retest Period/Powder for Oral Solution Shelf Life
18. Large-Scale Enantioselective Reduction of 2,3-Disubstituted Indenopyridine Enables a Practical Manufacturing Process for an 11β-HSD-1 Inhibitor
19. Best Practices for Drug Substance Stress and Stability Studies During Early-Stage Development Part I—Conducting Drug Substance Solid Stress to Support Phase Ia Clinical Trials
20. Copper-catalyzed asymmetric hydrogenation of 2-substituted ketones via dynamic kinetic resolution† †Electronic supplementary information (ESI) available. CCDC 1816601 and 1816602. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c8sc00434j
21. Activation of TMSCN by N-heterocyclic carbenes for facile cyanosilylation of carbonyl compounds
22. Atom-Economical Cross-Coupling of Internal and Terminal Alkynes to Access 1,3-Enynes
23. Sodium-Proton Exchanger Isoform-1: Synthesis of a Potent Inhibitor Labeled with Deuterium and Carbon-14
24. A practical and improved synthesis of (3S,5S)-3-[(tert-butyloxycarbonyl)methyl]-5-[(methanesulfonyloxy)methyl]-2-pyrrolidinone
25. Large Scale Practical Synthesis of Enantiomerically Pure cis-4-Amino-3-fluoro-1-methylpiperidine via Rhodium-Catalyzed Asymmetric Hydrogenation of a Tetrasubstituted Fluoroalkene
26. A concise synthesis of fusaric acid and (S)-(+)-fusarinolic acid
27. Large-Scale Enantioselective Reduction of 2,3-Disubstituted Indenopyridine Enables a Practical Manufacturing Process for an 11β-HSD-1 Inhibitor.
28. Practical synthesis of a cell adhesion inhibitor by self-regeneration of stereocenters
29. Cu-Catalyzed Asymmetric Aminoboration of E-Vinylarenes with pivZPhos as the Ligand
30. Large-Scale Enantioselective Reduction of 2,3-Disubstituted Indenopyridine Enables a Practical Manufacturing Process for an 11β-HSD-1 Inhibitor
31. Chiral auxiliaries & templates in large-scale API synthesis
32. Application of a Preformed Pd-BIDIME Precatalyst to Suzuki–Miyaura Cross-Coupling Reaction in Flow
33. Development of a Large-Scale Asymmetric Process for tert-Butanesulfinamide
34. Correction to “Computationally Assisted Mechanistic Investigation and Development of Pd-Catalyzed Asymmetric Suzuki–Miyaura and Negishi Cross-Coupling Reactions for Tetra-ortho-Substituted Biaryl Synthesis”
35. A versatile catalyst system for enantioselective synthesis of 2-substituted 1,4-benzodioxanes
36. Computationally Assisted Mechanistic Investigation and Development of Pd-Catalyzed Asymmetric Suzuki–Miyaura and Negishi Cross-Coupling Reactions for Tetra-ortho-Substituted Biaryl Synthesis
37. BABIPhos Family of Biaryl Dihydrobenzooxaphosphole Ligands for Asymmetric Hydrogenation
38. Synthesis of C1-C8 and C9-C24 fragments of (−)-discodermolide: use of asymmetric alkylation and stereoselective aldol reactions
39. Copper catalyzed asymmetric propargylation of aldehydes
40. Asymmetric synthesis of active pharmaceutical ingredients
41. Enantioselective Synthesis of α-(Hetero)aryl Piperidines through Asymmetric Hydrogenation of Pyridinium Salts and Its Mechanistic Insights
42. Development of a Scalable, Chromatography-Free Synthesis of t-Bu-SMS-Phos and Application to the Synthesis of an Important Chiral CF3-Alcohol Derivative with High Enantioselectivity Using Rh-Catalyzed Asymmetric Hydrogenation
43. P‐Stereogenic Chiral Phosphine−Palladium Complex Catalyzed Enantioselective Synthesis of Phosphoryl‐Substituted Atropisomeric Vinylarenes
44. Early Development Scale-Up of a Structurally-Challenging 5-Lipoxygenase Activating Protein (FLAP) Inhibitor
45. Enantioselective Nickel-Catalyzed Mizoroki–Heck Cyclizations To Generate Quaternary Stereocenters
46. General and Stereoselective Method for the Synthesis of Sterically Congested and Structurally Diverse P-Stereogenic Secondary Phosphine Oxides
47. Cu-Catalyzed Asymmetric Aminoboration of E‑Vinylarenes with pivZPhos as the Ligand.
48. Development of a concise, scalable synthesis of a CCR1 antagonist utilizing a continuous flow Curtius rearrangement
49. Sequential C–H Arylation and Enantioselective Hydrogenation Enables Ideal Asymmetric Entry to the Indenopiperidine Core of an 11β-HSD-1 Inhibitor
50. Reengineered BI‐DIME Ligand Core Based on Computer Modeling to Increase Selectivity in Asymmetric Suzuki–Miyaura Coupling for the Challenging Axially Chiral HIV Integrase Inhibitor
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