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The authors present sharp transformation inequalities for the zero-balanced hypergeometric function $${}_2F_1(a,b;a+b;r)$$ created by the transformations $$r\mapsto x=[(1-r)/(1+2r)]^3$$ and $$r\mapsto 1-x$$ , $$r\mapsto u=(1/2)r(3+r)^2(1+r)^{-3}$$ and $$r\mapsto 1-u$$ , $$r\mapsto p=(27/2)r(1+r)^4(1+4r+r^2)^{-3}$$ and $$r\mapsto 1-p$$ , by showing the monotonicity properties of certain combinations in terms of hypergeometric functions and elementary functions, thus extending the transformation identities satisfied by $${}_2F_1(1/3,2/3;1;r)$$ with these three pairs of transformations and substantively improving the related known results. With these results, some properties are obtained for the generalized Grotzsch ring functions and the modular functions appearing in Ramanujan’s modular equations. Some other properties of $${}_2F_1(a,b;c;r)$$ are obtained, too.

The authors present sharp Landen transformation inequalities for the hypergeometric functions F 1 2 ( a , b ; a + b ; x ) and F 1 2 ( a , b ; ( a + b + 1 ) / 2 ; x ) , by showing the monotonicity properties of certain combinations defined in terms of one of these two hypergeometric functions and linear (or rational) functions, thus giving complete solutions of the problem on extending the well-known Landen transformation identities for the complete elliptic integrals of the first kind to these two hypergeometric functions, and substantially improving the related known results. As applications of these results, sharp Landen transformation inequalities are obtained for the generalized Grotzsch ring functions and the modular functions, which appear in Ramanujan's modular equations. Some other properties of hypergeometric functions and several properties of the Ramanujan constant are obtained, too.

In this paper, the authors present sharp approximations in terms of sine function and polynomials for the so-called Ramanujan constant (or the Ramanujan $R$-function) $R(a)$, by showing some monotonicity, concavity and convexity properties of certain combinations defined in terms of $R(a)$, $\sin(\pi a)$ and polynomials. Some properties of the Riemann zeta function and its related special sums are presented, too., Comment: 19 pages

The authors obtain some monotonicity and concavity properties, and asymptotically sharp bounds for the generalized elliptic integral K a ( r ) of the first kind and its special case K ( r ) , the complete elliptic integral of the first kind, by studying the monotonicity and concavity properties of certain combinations defined in terms of the Gaussian hypergeometric function F ( a , 1 − a ; 1 ; x ) and elementary functions, thus improving some well-known results.

The authors present the power series expansions of the function R ( a ) − B ( a ) at a = 0 and at a = 1 / 2 , show the monotonicity and convexity properties of certain familiar combinations defined in terms of polynomials and the difference between the so-called Ramanujan constant R ( a ) and the beta function B ( a ) ≡ B ( a , 1 − a ) , and obtain asymptotically sharp lower and upper bounds for R ( a ) in terms of B ( a ) and polynomials. In addition, some properties of the Riemann zeta function ζ ( n ) , n ∈ N , and its related sums are derived.

In this paper, the authors present sharp bounds of the Hubner function M , which is defined by (1.11) and has important applications in the theories of quasiconformal maps and Ramanujan's modular equations, by showing the monotonicity and concavity-convexity properties of certain combinations defined in terms of M and elementary functions. By these results, several well-known results for M including its bounds and logarithmic inequalities, the explicit quasiconformal Schwarz lemma and the estimates of the solutions to Ramanujan's classical modular equations are remarkably improved. A simpler and more concise proof of the series expansion of M ( r ) is given, too.

In this paper, we study the quotient of hypergeometric functions μ a (r) in the theory of Ramanujan’s generalized modular equation for a ∈ (0, 1/2]. Several new inequalities are given for this and related functions. Our main results complement and generalize some known results in the literature.

In this paper, the authors show some monotonicity and concavity of the classical psi function, by which several known results are improved and some new asymptotically sharp estimates are obtained for this function. In addition, applying the new results to the psi function, the authors improve the well-known lower and upper bounds for the approximate evaluation of Euler’s constant γ.

For a ∈ ( 0 , 1 / 2 ] and r ∈ ( 0 , 1 ) , let K a ( r ) and E a ( r ) ( K ( r ) and E ( r ) ) denote the generalized elliptic integrals (the complete elliptic integrals, respectively) of the first and second kinds, respectively. In this paper, the authors present the necessary and sufficient conditions under which certain familiar combinations defined in terms of the generalized elliptic integrals and elementary functions are monotone in a ∈ ( 0 , 1 / 2 ] . By these results, sharp bounds expressed in terms of K ( r ) , E ( r ) and elementary functions are obtained for K a ( r ) and E a ( r ) , thus showing the dependence on the parameter a of K a ( r ) and E a ( r ) , and substantially improving the known related results.

In this paper, we prove that the double inequality \begin{equation*} 1+\alpha r'^2, Comment: 14 pages

In this paper, we present several bounds for the perimeter of an ellipse in terms of arithmetic, geometric, and harmonic means, which improve some known results. Mathematics subject classification (2010): 41A10, 33E05, 33C05, 26E60.

In this paper, we present some monotonicity theorems involving the generalized elliptic integrals Ka(r) and Ea(r) , and find an asymptotic property of Ka(r) when r → 1 . As applications, some well known results are improved. Mathematics subject classification (2010): 33E05.

In this paper, we establish a necessary and sufficient condition for the concavity of the complete elliptic integrals of the second kind with respect to Holder means.

In this paper, we present several bounds for the perimeter of an ellipse, which improve some well-known results.

In this paper, we present some sharp bounds for complete elliptic integrals of the second kind. As applications, we establish several inequalities for the perimeter of an ellipse.

In this paper, we establish several inequalities for the the generalized linear distortion function λ(a,K) by using the monotonicity and convexity of certain combinations λ(a,K)

Genome-wide association studies have identified susceptibility loci for esophageal squamous cell carcinoma (ESCC). We conducted a meta-analysis of all single-nucleotide polymorphisms (SNPs) that showed nominally significant P-values in two previously published genome-wide scans that included a total of 2961 ESCC cases and 3400 controls. The meta-analysis revealed five SNPs at 2q33 with P5 × 10(-8), and the strongest signal was rs13016963, with a combined odds ratio (95% confidence interval) of 1.29 (1.19-1.40) and P= 7.63 × 10(-10). An imputation analysis of 4304 SNPs at 2q33 suggested a single association signal, and the strongest imputed SNP associations were similar to those from the genotyped SNPs. We conducted an ancestral recombination graph analysis with 53 SNPs to identify one or more haplotypes that harbor the variants directly responsible for the detected association signal. This showed that the five SNPs exist in a single haplotype along with 45 imputed SNPs in strong linkage disequilibrium, and the strongest candidate was rs10201587, one of the genotyped SNPs. Our meta-analysis found genome-wide significant SNPs at 2q33 that map to the CASP8/ALS2CR12/TRAK2 gene region. Variants in CASP8 have been extensively studied across a spectrum of cancers with mixed results. The locus we identified appears to be distinct from the widely studied rs3834129 and rs1045485 SNPs in CASP8. Future studies of esophageal and other cancers should focus on comprehensive sequencing of this 2q33 locus and functional analysis of rs13016963 and rs10201587 and other strongly correlated variants.

We find the greatest value α1 and α2, and the least values β1 and β2, such that the double inequalities α1S(a,b) + (1 − α1) A(a,b) 0 with a ≠ b. As applications, we get two new bounds for the complete elliptic integral of the second kind in terms of elementary functions. Here, S(a,b) = [(a2 + b2)/2]1/2, A(a,b) = (a + b)/2, and \(T(a,b)=\frac{2}{\pi}\int\limits_{0}^{{\pi}/{2}}\sqrt{a^2{\cos^2{\theta}}+b^2{\sin^2{\theta}}}{\rm d}\theta\) denote the root-square, arithmetic, and Toader means of two positive numbers a and b, respectively.

In this paper, the authors prove some inequalities for the generalized elliptic integrals with respect to Holder means.

In this paper, we establish some functional inequalities for the generalized HerschPfluger distortion function φK(a,r) , and prove a submultiplicative property for the generalized Agard distortion function ηK(a,x) . Mathematics subject classification (2010): 33E05, 30C62.

In this paper, we study the monotonicity properties of the generalized elliptic integrals and establish two Holder mean inequalities for the generalized Grotzsch ring function μa(r) and the generalized Hersch-Pfluger distortion function φa K(r) . Mathematics subject classification (2010): 30C62, 33E05.

Li Dong Wang and colleagues report a genome wide association study for esophageal squamous cell carcinoma in the Chinese population. They identify two risk loci at PLCE1 and C20orf54.

New better estimates, which are given in terms of elementary functions, for the function r 7→ (2/�)(1 − r 2 )K(r)K ' (r) + log r appearing in Hubner's sharp upper bound for the Hersch-Pfluger distortion function are obtained. With these estimates, some known bounds for the Hersch-Pfluger distortion function in quasiconformal theory are improved, thus improving the explicit quasiconformal Schwarz lemma and some known estimates for the solutions to the Ramanujan modular equations.

In this paper, the authors show a relation between the generalized convexity and super- (sub-)multiplicative property, and discuss some generalized convexity and inequalities involving the Gaussian hypergeometric function, the generalized η-distortion function η K a ( x ) and the generalized Grotzsch function μ a ( r ) .

In this paper, some monotoneity and concavity properties of the gamma, beta and psi functions are obtained, from which several asymptotically sharp inequalities follow. Applying these properties, the authors improve some well-known results for the volume Ω n \Omega _n of the unit ball B n ⊂ R n B^n\subset \mathbb {R}^n , the surface area ω n − 1 \omega _{n-1} of the unit sphere S n − 1 S^{n-1} , and some related constants.

We present various new inequalities involving the logarithmic mean $ L(x,y)=(x-y)/(\log{x}-\log{y}) $ , the identric mean $ I(x,y)=(1/e)(x^x/y^y)^{1/(x-y)} $ , and the classical arithmetic and geometric means, $ A(x,y)=(x+y)/2 $ and $ G(x,y)=\sqrt{xy} $ . In particular, we prove the following conjecture, which was published in 1986 in this journal. If $ M_r(x,y)= (x^r/2+y^r/2)^{1/r}(r\neq{0}) $ denotes the power mean of order r, then $ M_c(x,y)(\frac{1}{2}(L(x,y)+I(x,y)) {(x,y>0,\, x\neq{y})} $ with the best possible parameter $ c=(\log{2})/(1+\log{2}) $ .

For and , we prove that the elliptic Neuman mean is strictly Schur quadratically concave on if and only if . As an application, the bounds for elliptic Neuman mean in terms of the quadratic mean are presented. MSC:26B25, 26E60.

The objective of this study was to quantify the changes in p53 and cyclin DI protein levels in different stages of human esophageal and gastric cardia carcinogenesis in a high-risk population in Henan, China. Immunoreactivity of p53, cyclin DI and proliferating-cell nuclear antigen (PCNA) was observed in the cell nuclei of esophageal and gastric cardia biopsies. The number of p53-immunostaining-positive cells was low in normal epithelia, slightly increased in basal-cell hyperplasia (BCH), markedly increased in dysplasia (DYS) (10-fold), and further increased in squamous-cell carcinoma (SCC) (40-fold). This pattern of change was similar to that of cell proliferation as indicated by PCNA immunostaining. On the other hand, the number of cyclin DI-immunostaining-positive cells did not increase from BCH to DYS, although a slight increase from DYS to SCC was noted. In the gastric cardia, again, the pattern of change of p53-positive cells in different stages of lesions paralleled the pattern of cell proliferation. The number of p53-positive cells was very low, much lower than that of PCNA-positive cells, in normal, chronic superficial gastritis (CSG) and chronic atrophic gastritis (CAG); therefore, the increase of p53-positive cells from CAG to DYS was more dramatic (100-fold). From DYS to adenocarcinoma (AC), the p53-positive and the PCNA-positive cells increased 4-fold. On the other hand, the number of cyclin DI-positive cells did not increase in pre-cancerous lesions, but increased slightly in AC. This study demonstrates that p53 protein accumulation increased with the progression of pre-cancerous lesions, especially in the genesis of dysplasia, both in the esophagus and in the gastric cardia. Our approach of quantitative immunohistochemistry sheds light on the mechanisms of genesis of esophageal and gastric-cardia cancers, which frequently occur together in many highincidence areas. © 1994 Wiley-Liss, Inc.

Forp∈[0,1], the generalized Seiffert mean of two positive numbersaandbis defined bySp(a,b)=p(a-b)/arctan[2p(a-b)/(a+b)], 00witha≠b, and give new bounds for the complete elliptic integrals of the second kind. Here,T(a,b)=(2/π)∫0π/2a2cos⁡2θ+b2sin⁡2θdθdenotes the Toader mean of two positive numbersaandb.

We performed a genome-wide association study of esophageal squamous cell carcinoma (ESCC) by genotyping 1,077 individuals with ESCC and 1,733 control subjects of Chinese Han descent. We selected 18 promising SNPs for replication in an additional 7,673 cases of ESCC and 11,013 control subjects of Chinese Han descent and 303 cases of ESCC and 537 control subjects of Chinese Uygur-Kazakh descent. We identified two previously unknown susceptibility loci for ESCC: PLCE1 at 10q23 (P(Han combined for ESCC) = 7.46 x 10(-56), odds ratio (OR) = 1.43; P(Uygur-Kazakh for ESCC) = 5.70 x 10(-4), OR = 1.53) and C20orf54 at 20p13 (P(Han combined for ESCC) = 1.21 x 10(-11), OR = 0.86; P(Uygur-Kazakh for ESCC) = 7.88 x 10(-3), OR = 0.66). We also confirmed association in 2,766 cases of gastric cardia adenocarcinoma cases and the same 11,013 control subjects (PLCE1, P(Han for GCA) = 1.74 x 10(-39), OR = 1.55 and C20orf54, P(Han for GCA) = 3.02 x 10(-3), OR = 0.91). PLCE1 and C20orf54 have important biological implications for both ESCC and GCA. PLCE1 might regulate cell growth, differentiation, apoptosis and angiogenesis. C20orf54 is responsible for transporting riboflavin, and deficiency of riboflavin has been documented as a risk factor for ESCC and GCA.

Nat. Genet. 42, 759–763 (2010); published online 22 August 2010; corrected after print 27 August 2014 In contrast to the version of this article initially published, the authors now find no evidence to support association with esophageal squamous cell carcinoma susceptibility for rs13042395[T] at 20p13 in their original data, in two independent sets of cases and controls collected in other Chinese populations or in the joint analysis of these three studies.