Search

Your search keyword '"Sopracordevole, Francesco"' showing total 329 results
Start Over Author "Sopracordevole, Francesco"
329 results on '"Sopracordevole, Francesco"'

1. Chemo-conization in Early-sTage cERvical caNcer >2 cm scheduled for fertilItY-sparing approach: an analysis of the ETERNITY project

Author

Bogani, Giorgio, Scambia, Giovanni, Fagotti, Anna, Fanfani, Francesco, De Vincenzo, Rosa, Ciavattini, Andrea, Sopracordevole, Francesco, Clemente, Nicolò, Del Fabro, Anna, Buttignol, Monica, Cianci, Stefano, Sarpietro, Giuseppe, Matarazzo, Maria Grazia, Malzoni, Mario, Falcone, Francesca, Casarin, Jvan, Ghezzi, Fabio, Vizza, Enrico, Berretta, Roberto, Petrillo, Marco, Capobianco, Giampiero, Scarfone, Giovanna, Casaccia, Filippo, Fichera, Mariasole, Leo, Livio, Sozzi, Giulio, Colalillo, Alessio, Cosentino, Francesco, Gardella, Barbara, Serrachioli, Renato, Raimondo, Diego, Chiantera, Vito, Ercoli, Alfredo, Dominoni, Mattia, Zupi, Enrico, Centini, Gabriele, Uccella, Stefano, Franchi, Massimo, Ferrari, Filippo Alberto, Perrone, Anna Myriam, De Iaco, Pierandrea, Multinu, Francesco, Zanagnolo, Vanna, Schivardi, Gabriella, De Vitis, Luigi Antonio, Cuccu, Ilaria, Ferrari, Federico, Vizzielli, Giuseppe, Restaino, Stefano, Driul, Lorenza, Arcieri, Martina, Sorbi, Flavia, Fambrini, Massimiliano, Aguzzoli, Lorenzo, Mandato, Vincenzo Dario, Murina, Filippo, Solima, Eugenio, Vignali, Michele, Vercellini, Paolo, Ceccaroni, Marcello, Di Donato, Violante, Giannini, Andrea, Muzii, Ludovico, Chiappa, Valentina, Palladino, Simona, Tozzi, Roberto, Amant, Frédéric, and Raspagliesi, Francesco

Published
2025
Full Text
View/download PDF

2. Sentinel node mapping, sentinel node mapping plus back-up lymphadenectomy, and lymphadenectomy in Early-sTage cERvical caNcer scheduled for fertilItY-sparing approach: The ETERNITY project

Author

Bogani, Giorgio, Scambia, Giovanni, Fagotti, Anna, Fanfani, Francesco, De Vincenzo, Rosa, Ciavattini, Andrea, Sopracordevole, Francesco, Clemente, Nicolò, Del Fabro, Anna, Buttignol, Monica, Cianci, Stefano, Sarpietro, Giuseppe, Matarazzo, Maria Grazia, Malzoni, Mario, Falcone, Francesca, Casarin, Jvan, Ghezzi, Fabio, Vizza, Enrico, Berretta, Roberto, Petrillo, Marco, Capobianco, Giampiero, Scarfone, Giovanna, Casaccia, Filippo, Fichera, Mariasole, Leo, Livio, Sozzi, Giulio, Colalillo, Alessio, Cosentino, Francesco, Gardella, Barbara, Serrachioli, Renato, Raimondo, Diego, Chiantera, Vito, Ercoli, Alfredo, Dominoni, Mattia, Zupi, Enrico, Centini, Gabriele, Uccella, Stefano, Franchi, Massimo, Ferrari, Filippo Alberto, Perrone, Anna Myriam, De Iaco, Pierandrea, Multinu, Francesco, Zanagnolo, Vanna, Schivardi, Gabriella, De Vitis, Luigi Antonio, Cuccu, Ilaria, Ferrari, Federico, Vizzielli, Giuseppe, Restaino, Stefano, Driul, Lorenza, Arcieri, Martina, Sorbi, Flavia, Fambrini, Massimiliano, Aguzzoli, Lorenzo, Mandato, Vincenzo Dario, Murina, Filippo, Solima, Eugenio, Vignali, Michele, Vercellini, Paolo, Ceccaroni, Marcello, Di Donato, Violante, Giannini, Andrea, Muzii, Ludovico, Chiappa, Valentina, Palladino, Simona, Tozzi, Roberto, Cormio, Gennaro, and Raspagliesi, Francesco

Published
2024
Full Text
View/download PDF

3. Correction: Clinical validation of full HR-HPV genotyping HPV Selfy assay according to the international guidelines for HPV test requirements for cervical cancer screening on clinician-collected and self-collected samples

Author

Avian, Alice, Clemente, Nicolò, Mauro, Elisabetta, Isidoro, Erica, Di Napoli, Michela, Dudine, Sandra, Del Fabro, Anna, Morini, Stefano, Perin, Tiziana, Giudici, Fabiola, Cammisuli, Tamara, Foschi, Nicola, Mocenigo, Marco, Montrone, Michele, Modena, Chiara, Polenghi, Martina, Puzzi, Luca, Tomaic, Vjekoslav, Valenti, Giulio, Sola, Riccardo, Zanolla, Shivani, Vogrig, Enea, Riva, Elisabetta, Angeletti, Silvia, Ciccozzi, Massimo, Castriciano, Santina, Pachetti, Maria, Petti, Matteo, Centonze, Sandro, Gerin, Daniela, Banks, Lawrence, Marini, Bruna, Canzonieri, Vincenzo, Sopracordevole, Francesco, Zanconati, Fabrizio, and Ippodrino, Rudy

Published
2023
Full Text
View/download PDF

5. Ten-year outcomes following laparoscopic and open abdominal radical hysterectomy for “low-risk” early-stage cervical cancer: A propensity-score based analysis

Author

Di Donato, Violante, Bogani, Giorgio, Casarin, Jvan, Ghezzi, Fabio, Malzoni, Mario, Falcone, Francesca, Petrillo, Marco, Capobianco, Giampiero, Calò, Filippo, D’Augè, Tullio Golia, Muzii, Ludovico, Benedetti Panici, Pierluigi, Ervas, Elisa, Ditto, Antonino, Raspagliesi, Francesco, Sopracordevole, Francesco, Vizza, Enrico, and Giannini, Andrea

Published
2023
Full Text
View/download PDF

8. Practice patterns and 90-day treatment-related morbidity in early-stage cervical cancer

Author

Bogani, Giorgio, Donato, Violante Di, Scambia, Giovanni, Ghezzi, Fabio, Casarin, Jvan, Landoni, Fabio, Di Martino, Giampaolo, Grassi, Tommaso, Perrone, Anna Myriam, De Iaco, Pierandrea, Multinu, Francesco, Berretta, Roberto, Capozzi, Vito A., Zupi, Errico, Centini, Gabriele, Pellegrino, Antonio, Corso, Silvia, Stevenazzi, Guido, Boschi, Anna Chiara, Comerci, Giuseppe, Greco, Pantaleo, Scutiero, Gennaro, Sopracordevole, Francesco, Giorda, Giorgio, Fichera, Mariasole, Simoncini, Tommaso, Caretto, Marta, Sartori, Enrico, Ferrari, Federico, Cianci, Antonio, Sarpietro, Giuseppe, Matarazzo, Maria Grazia, Giampaolino, Pierluigi, Bifulco, Giuseppe, Morelli, Michele, Dio, Michele Di, Ferrero, Annamaria, Biglia, Nicoletta, Barra, Fabio, Ferrero, Simone, Cianci, Stefano, Chiantera, Vito, Sozzi, Giulio, Ercoli, Alfredo, Schettini, Sergio, Orlando, Teresa, Cannone, Francesco G., Ettore, Giuseppe, Puppo, Andrea, Olearo, Elena, Leone Roberti Maggiore, Umberto, Artuso, Valeria, Palaia, Innocenza, Perniola, Giorgia, Tripodi, Rossana, D'Augè, Tullio Golia, Cuccu, Ilaria, Fischetti, Margherita, Santangelo, Giusi, Casorelli, Assunta, Giannini, Andrea, D’Oria, Ottavia, Vizzielli, Giuseppe, Restaino, Stefano, Bergamini, Alice, Bocciolone, Luca, Plotti, Francesco, Angioli, Roberto, Mantovani, Giulia, Ceccaroni, Marcello, Cassini, Chiara, Dominoni, Mattia, Giambanco, Laura, Amodeo, Silvia, Leo, Livio, Thommaset, Raphaël, Raimondo, Diego, Seracchioli, Renato, Malzoni, Mario, Falcone, Francesca, Gorlero, Franco, Di Luca, Martina, Busato, Enrico, Kilzie, Sami, Dell'Acqua, Andrea, Scarfone, Giovanna, Vercellini, Paolo, Petrillo, Marco, Capobianco, Giampiero, Ciavattini, Andrea, Mereu, Liliana, Scollo, Paolo, Sorbi, Flavia, Fambrini, Massimiliano, Romano, Federico, Ricci, Giuseppe, Trojano, Giuseppe, Damiani, Gianluca Raffaello, Consonni, Roberto, Di Lorenzo, Nadia, Lippolis, Antonio, Tinelli, Raffaele, Aguzzoli, Lorenzo, Mandato, Vincenzo D., Palomba, Stefano, Tripodi, Marcello, Calandra, Davide, Pellegrini, Franco, Zullo, Fulvio, Surico, Daniela, Remorgida, Valentino, Ruscitto, Francesco, Beretta, Paolo, Vizza, Enrico, Muzii, Ludovico, Panici, Pierluigi Benedetti, and Raspagliesi, Francesco

Published
2022
Full Text
View/download PDF

9. Management of Patients with Vulvar Cancers: A Systematic Comparison of International Guidelines (NCCN–ASCO–ESGO–BGCS–IGCS–FIGO–French Guidelines–RCOG).

Author

Restaino, Stefano, Pellecchia, Giulia, Arcieri, Martina, Bogani, Giorgio, Taliento, Cristina, Greco, Pantaleo, Driul, Lorenza, Chiantera, Vito, De Vincenzo, Rosa Pasqualina, Garganese, Giorgia, Sopracordevole, Francesco, Di Donato, Violante, Ciavattini, Andrea, Scollo, Paolo, Scambia, Giovanni, and Vizzielli, Giuseppe

Subjects
MEDICAL protocols, ELECTROTHERAPEUTICS, BIOPSY, PALLIATIVE treatment, DISEASE management, ONCOLOGIC surgery, IMMUNOTHERAPY, VULVAR tumors, MEDICAL societies, CANCER chemotherapy, PLASTIC surgery, HEALTH care teams
Abstract

Simple Summary: Vulvar tumors are uncommon and have a considerable impact on the functional and aesthetic well-being of those affected. Their treatment necessitates a comprehensive, multidisciplinary approach at various levels, highlighting the importance of having standardized recommendations that are aligned with the latest scientific findings. Are scientific guidelines aligning with the advancements made in this field of oncology, spanning from diagnosis to palliative care at various levels? To address this, we conducted a systematic comparison of the main European and American guidelines for vulvar cancer management to assess their current status of update. From our comparisons, many divergences emerged in management strategies. Among them, lack of reference to the most up-to-date diagnostic classification systems, indication for an integrated gyneco-oncologic and plastic surgical approach to postoperative management with the most modern advanced dressing devices and palliative setting with the use of immuno- and electrochemotherapy. Background: Vulvar carcinoma is an uncommon gynecological tumor primarily affecting older women. Its treatment significantly impacts the quality of life and, not least, aesthetics because of the mutilating surgery it requires. Objectives: The management requires a multidisciplinary team of specialists who know how to care for the patient in her entirety, not neglecting psychological aspects and reconstructive surgery. How do the guidelines address multidisciplinarity, team surgical management, passing through preoperative diagnosis, and follow-up in such a challenging rare tumor to treat? Methods: To answer these questions, we compared the main scientific recommendations to identify similarities and differences in diagnostic and therapeutic management to provide an overview of the gaps that there are currently in European and American international recommendations in providing management guidance in a cancer that is both among the rarest and most difficult to manage. In this way, we aim to encourage an update in practices based on the latest scientific evidence. Results: A review of various international guidelines, some dating back to 2014, shows significant variation in approaches, ranging from initial diagnostic procedures to managing relapses. The most recent guidelines also lacked references to the latest literature, indicating that more robust scientific evidence is needed before new treatments, such as electrochemotherapy for palliation and reconstructive surgery post exenteration, can be widely adopted. Conclusions: From the systematic comparison of the main international guidelines, a strong heterogeneity emerged in the diagnostic and therapeutic recommendations as well as for the multidisciplinary approach that today is essential. Our work certainly stimulated an update of the main guidelines. [ABSTRACT FROM AUTHOR]

Published
2025
Full Text
View/download PDF

10. Role of Age, Comorbidity, and Frailty in the Prediction of Postoperative Complications After Surgery for Vulvar Cancer: A Retrospective Cohort Study with the Development of a Nomogram.

Author

Delli Carpini, Giovanni, Sopracordevole, Francesco, Cicoli, Camilla, Bernardi, Marco, Giuliani, Lucia, Fichera, Mariasole, Clemente, Nicolò, Del Fabro, Anna, Di Giuseppe, Jacopo, Giannella, Luca, Busato, Enrico, and Ciavattini, Andrea

Subjects
*PREOPERATIVE risk factors, *VULVAR cancer, *OLDER patients, *SURGICAL complications, *BODY mass index
Abstract

Surgery is the cornerstone of vulvar cancer treatment, but it is associated with a significant risk of complications that may impact prognosis, particularly in older patients with multiple comorbidities. The objective of this study was to evaluate the role of age, comorbidities, and frailty in predicting postoperative complications after vulvar cancer surgery and to develop a predictive nomogram. A retrospective cohort study was conducted, including patients who underwent surgery for vulvar cancer at two Italian institutions from January 2018 to December 2023. A logistic regression model for the rate of Clavien-Dindo 2+ 30-days complications was run, considering the age-adjusted Charlson Comorbidity Index (AACCI), body mass index (BMI), and frailty as exposures. Lesion characteristics and surgical procedures were considered as confounders. Among the 225 included patients, 50 (22.2%) had a grade 2+ complication. The predictive score of the nomogram ranged from 44 to 140. The AACCI (0–64 points) and BMI (0–100 points) were independently associated with a risk of complications. A nomogram including the AACCI and BMI predicts the risk of complications for patients undergoing surgery for vulvar cancer. The preoperative determination of the risk of complications enables surgical planning and allows a tailored peri- and postoperative management plan. [ABSTRACT FROM AUTHOR]

Published
2025
Full Text
View/download PDF

12. Clinical validation of full HR-HPV genotyping HPV Selfy assay according to the international guidelines for HPV test requirements for cervical cancer screening on clinician-collected and self-collected samples

Author

Avian, Alice, Clemente, Nicolò, Mauro, Elisabetta, Isidoro, Erica, Di Napoli, Michela, Dudine, Sandra, Del Fabro, Anna, Morini, Stefano, Perin, Tiziana, Giudici, Fabiola, Cammisuli, Tamara, Foschi, Nicola, Mocenigo, Marco, Montrone, Michele, Modena, Chiara, Polenghi, Martina, Puzzi, Luca, Tomaic, Vjekoslav, Valenti, Giulio, Sola, Riccardo, Zanolla, Shivani, Vogrig, Enea, Riva, Elisabetta, Angeletti, Silvia, Ciccozzi, Massimo, Castriciano, Santina, Pachetti, Maria, Petti, Matteo, Centonze, Sandro, Gerin, Daniela, Banks, Lawrence, Marini, Bruna, Canzonieri, Vincenzo, Sopracordevole, Francesco, Zanconati, Fabrizio, and Ippodrino, Rudy

Published
2022
Full Text
View/download PDF

13. High-risk HPV-positive and -negative high-grade cervical dysplasia: Analysis of 5-year outcomes

Author

Bogani, Giorgio, Sopracordevole, Francesco, Di Donato, Violante, Ciavattini, Andrea, Ghelardi, Alessandro, Lopez, Salvatore, Simoncini, Tommaso, Plotti, Francesco, Casarin, Jvan, Serati, Maurizio, Pinelli, Ciro, Valenti, Gaetano, Bergamini, Alice, Gardella, Barbara, Dell'acqua, Andrea, Monti, Ermelinda, Vercellini, Paolo, Fischetti, Margherita, D'ippolito, Giovanni, Aguzzoli, Lorenzo, Mandato, Vincenzo D., Carunchio, Paola, Carlinfante, Gabriele, Giannella, Luca, Scaffa, Cono, Falcone, Francesca, Borghi, Chiara, Ditto, Antonino, Malzoni, Mario, Giannini, Andrea, Salerno, Maria Giovanna, Liberale, Viola, Contino, Biagio, Donfrancesco, Cristina, Desiato, Michele, Perrone, Anna Myriam, Dondi, Giulia, De Iaco, Pierandrea, Chiappa, Valentina, Ferrero, Simone, Sarpietro, Giuseppe, Matarazzo, Maria G., Cianci, Antonio, Bosio, Sara, Ruisi, Simona, Guerrisi, Rocco, Brusadelli, Claudia, Mosca, Lavinia, Lagana’, Antonio Simone, Tinelli, Raffaele, Signorelli, Mauro, De Vincenzo, Rosa, Zannoni, Gian Franco, Ferrandina, Gabriella, Lovati, Sara, Petrillo, Marco, Dessole, Salvatore, Carlea, Annunziata, Zullo, Fulvio, Angioli, Roberto, Greggi, Stefano, Spinillo, Arsenio, Ghezzi, Fabio, Colacurci, Nicola, Muzii, Ludovico, Benedetti Panici, Pierluigi, Scambia, Giovanni, and Raspagliesi, Francesco

Published
2021
Full Text
View/download PDF

14. Spotlight on the role of human papillomavirus vaccines

Author

Bogani, Giorgio, Raspagliesi, Francesco, di Donato, Violante, Brusadelli, Claudia, Guerrisi, Rocco, Pinelli, Ciro, Casarin, Jvan, Ghezzi, Fabio, Del Fabro, Anna, Ditto, Antonino, Simoncini, Tommaso, Ciavattini, Andrea, and Sopracordevole, Francesco

Published
2021
Full Text
View/download PDF

15. Recurrence rate after loop electrosurgical excision procedure (LEEP) and laser Conization: A 5-year follow-up study

Author

BOGANI, Giorgio, DI DONATO, Violante, SOPRACORDEVOLE, Francesco, CIAVATTINI, Andrea, GHELARDI, Alessandro, LOPEZ, Salvatore, SIMONCINI, Tommaso, PLOTTI, Francesco, CASARIN, Jvan, SERATI, Maurizio, PINELLI, Ciro, VALENTI, Gaetano, BERGAMINI, Alice, GARDELLA, Barbara, DELL'ACQUA, Andrea, MONTI, Ermelinda, VERCELLINI, Paolo, FISCHETTI, Margherita, D'IPPOLITO, Giovanni, AGUZZOLI, Lorenzo, MANDATO, Vincenzo D., CARUNCHIO, Paola, CARLINFANTE, Gabriele, GIANNELLA, Luca, SCAFFA, Cono, FALCONE, Francesca, BORGHI, Chiara, DITTO, Antonino, MALZONI, Mario, GIANNINI, Andrea, SALERNO, Maria Giovanna, LIBERALE, Viola, CONTINO, Biagio, DONFRANCESCO, Cristina, DESIATO, Michele, PERRONE, Anna Myriam, DONDI, Giulia, De IACO, Pierandrea, LEONE ROBERTI MAGGIORE, Umberto, SIGNORELLI, Mauro, CHIAPPA, Valentina, FERRERO, Simone, SARPIETRO, Giuseppe, MATARAZZO, Maria G., CIANCI, Antonio, BOSIO, Sara, RUISI, Simona, GUERRISI, Rocco, BRUSADELLI, Claudia, MOSCA, Lavinia, TINELLI, Raffaele, DE VINCENZO, Rosa, ZANNONI, Gian Franco, FERRANDINA, Gabriella, PETRILLO, Marco, DESSOLE, Salvatore, ANGIOLI, Roberto, GREGGI, Stefano, SPINILLO, Arsenio, GHEZZI, Fabio, COLACURCI, Nicola, MUZII, Ludovico, BENEDETTI PANICI, Pierluigi, SCAMBIA, Giovanni, and RASPAGLIESI, Francesco

Published
2020
Full Text
View/download PDF

16. Human epidermal growth factor receptor-2 (HER2) is a potential therapeutic target in extramammary Paget’s disease of the vulva

Author

Bartoletti, Michele, Mazzeo, Roberta, De Scordilli, Marco, Del Fabro, Anna, Vitale, Maria Grazia, Bortot, Lucia, Nicoloso, Milena Sabrina, Corsetti, Serena, Bonotto, Marta, Scalone, Simona, Giorda, Giorgio, Sorio, Roberto, Andreetta, Claudia, Meacci, Maria Luisa, De Vivo, Rocco, Fasola, Gianpiero, Sopracordevole, Francesco, and Puglisi, Fabio

Published
2020
Full Text
View/download PDF

17. A Longitudinal Multiinstitutional Study of Vulvar Lichen Sclerosus: From Childhood to Perimenopause

Author

Di Giuseppe, Jacopo, primary, Delli Carpini, Giovanni, additional, Giannella, Luca, additional, Terenzi, Tomas, additional, Fichera, Mariasole, additional, Ragno, Federica, additional, Campanati, Anna, additional, Boero, Veronica, additional, Caia, Carlotta, additional, Pesce, Elisa, additional, Vercellini, Paolo, additional, Gardella, Barbara, additional, Dominoni, Mattia, additional, Spinillo, Arsenio, additional, Sopracordevole, Francesco, additional, Clemente, Nicolò, additional, Del Fabro, Anna, additional, Rossi, Riccardo, additional, Corazza, Monica, additional, Borghi, Alessandro, additional, Martinello, Ruby, additional, Greco, Pantaleo, additional, Rizzo, Giuseppe, additional, Criscuolo, Anna Angela, additional, Mappa, Ilenia, additional, Matteini, Enrico, additional, Botti, Elisabetta, additional, Campione, Elena, additional, Bianchi, Luca, additional, and Ciavattini, Andrea, additional

Published
2024
Full Text
View/download PDF

20. Reliability of colposcopy during pregnancy

Author

Ciavattini, Andrea, Serri, Matteo, Di Giuseppe, Jacopo, Liverani, Carlo A., Fallani, Maria G., Tsiroglou, Dimitrios, Papiccio, Maria, Delli Carpini, Giovanni, Pieralli, Annalisa, Clemente, Nicolò, and Sopracordevole, Francesco

Published
2018
Full Text
View/download PDF

21. Role of Close Endocervical Margin in Treatment Failure After Cervical Excision for Cervical Intraepithelial Neoplasia: A Retrospective Study

Author

Sopracordevole, Francesco, Carpini, Giovanni Delli, Del Fabro, Anna, Serri, Matteo, Alessandrini, Lara, Buttignol, Monica, Canzonieri, Vincenzo, Cagnacci, Angelo, and Ciavattini, Andrea

Subjects
Analysis, Laser, Recurrence (Disease) -- Analysis, Lasers -- Analysis, Cervix dysplasia -- Analysis
Abstract

Cervical intraepithelial neoplasia (CIN) is a potentially premalignant lesion of the uterine cervix, with a risk of progression to invasive cervical cancer related to the severity and size of the [...], * Context.--A significant negative trend in length of cone excision has been observed in recent years, leading to a higher percentage of positive endocervical excision margin and close ( Objective.--To evaluate the rate of disease persistence and recurrence after cervical excision for cervical intraepithelial neoplasia in relation to a close ( Design.--We retrospectively analyzed a cohort of patients with cervical intraepithelial neoplasia having a carbon dioxide laser cervical excision performed by the same operator. We evaluated the rate of positive follow-up in relation to the status of endocervical margin. Results.--We found a higher percentage of positivity at follow-up and recurrence rate between 13 and 24 months in patients with positive margin than for patients with negative or close endocervical margin (P =.005 and P = .006, respectively), with no difference between negative and close margin (7.0% versus 8.3%, P =.89, and 1.2% versus 0%, P =.83, respectively). Conclusions.--Women with close and negative endocervical margin presented similar risk of positivity at longterm follow-up, disease persistence, and recurrence between 13 and 24 months, so the histopathologic report of a free endocervical margin less than 1 mm should not categorize the patient as being at increased risk of treatment failure. Therefore, the only information that the pathologist should report is the state of the margin (positive or negative), regardless of the negative endocervical margin length. (Arch Pathol Lab Med. 2019;143:1006-1011; doi:10.5858/arpa.2018-0363-OA)

Published
2019
Full Text
View/download PDF

23. Concurrent Endometrial Cancer in Women with Atypical Endometrial Hyperplasia: What Is the Predictive Value of Patient Characteristics?

Author

Giannella, Luca, primary, Piva, Francesco, additional, Delli Carpini, Giovanni, additional, Di Giuseppe, Jacopo, additional, Grelloni, Camilla, additional, Giulietti, Matteo, additional, Sopracordevole, Francesco, additional, Giorda, Giorgio, additional, Del Fabro, Anna, additional, Clemente, Nicolò, additional, Gardella, Barbara, additional, Bogani, Giorgio, additional, Brasile, Orsola, additional, Martinello, Ruby, additional, Caretto, Marta, additional, Ghelardi, Alessandro, additional, Albanesi, Gianluca, additional, Stevenazzi, Guido, additional, Venturini, Paolo, additional, Papiccio, Maria, additional, Cannì, Marco, additional, Barbero, Maggiorino, additional, Fambrini, Massimiliano, additional, Maggi, Veronica, additional, Uccella, Stefano, additional, Spinillo, Arsenio, additional, Raspagliesi, Francesco, additional, Greco, Pantaleo, additional, Simoncini, Tommaso, additional, Petraglia, Felice, additional, and Ciavattini, Andrea, additional

Published
2023
Full Text
View/download PDF

24. Clinical Characteristics and Long-Term Follow-up of Patients Treated for High-Grade Vaginal Intraepithelial Neoplasia: Results From a 20-Year Survey in Italy

Author

Sopracordevole, Francesco, Clemente, Nicolò, Di Giuseppe, Jacopo, Barbero, Maggiorino, Fallani, Maria Grazia, Cattani, Paolo, Agarossi, Alberto, Del Fabro, Anna, De Piero, Giovanni, Pieralli, Annalisa, Giannella, Luca, Morini, Stefano, Parin, Alberto, Boselli, Fausto, Buttignol, Monica, Nicodemo, Martina, Delli Carpini, Giovanni, and Ciavattini, Andrea

Published
2020
Full Text
View/download PDF

26. #427 Ten-year outcomes following laparoscopic and open abdominal radical hysterectomy for ‘low-risk’ early-stage cervical cancer: a propensity-score based analysis

Author

D’augè, Tullio Golia, primary, Donato, Violante Di, additional, Bogani, Giorgio, additional, Casarin, Jvan, additional, Ghezzi, Fabio, additional, Malzoni, Mario, additional, Falcone, Francesca, additional, Petrillo, Marco, additional, Capobianco, Giampiero, additional, Calò, Filippo, additional, Muzii, Ludovico, additional, Panici, Pierluigi Benedetti, additional, Ervas, Elisa, additional, Ditto, Antonino, additional, Raspagliesi, Francesco, additional, Sopracordevole, Francesco, additional, Vizza, Enrico, additional, and Giannini, Andrea, additional

Published
2023
Full Text
View/download PDF

28. HPV-related lesions after hysterectomy for high-grade cervical intraepithelial neoplasia and early-stage cervical cancer: A focus on the potential role of vaccination

Author

Bogani, Giorgio, Sopracordevole, Francesco, Ciavattini, Andrea, Ghelardi, Alessandro, Vizza, Enrico, Vercellini, Paolo, Casarin, Jvan, Pinelli, Ciro, Ghezzi, Fabio, De Vincenzo, Rosa, Di Donato, Violante, Golia D’augè, Tullio, Giannini, Andrea, Sorbi, Flavia, Petrillo, Marco, Capobianco, Giampiero, Vizzielli, Giuseppe, Restaino, Stefano, Cianci, Stefano, Scambia, Giovanni, and Raspagliesi, Francesco

Abstract

Objective: To date, no data supports the execution of vaccination after hysterectomy for high-grade cervical intraepithelial neoplasia (CIN2+) and early-stage cervical cancer. We aim to evaluate the potential effect of vaccination after hysterectomy for high-grade cervical intraepithelial neoplasia and early-stage cervical cancer.Methods: This is a multi-center retrospective study evaluating data of women who develop lower genital tract dysplasia (including anal, vulvar and vaginal intra-epithelial neoplasia) after having hysterectomy for CIN2+ and FIGO stage IA1- IB1 cervical cancer.Results: Overall, charts for 77 patients who developed lower genital tract dysplasia were collected. The study population included 62 (80.5%) and 15 (19.5%) patients with CIN2+ and early-stage cervical cancer, respectively. The median (range) time between hysterectomy and diagnosis of develop lower genital tract dysplasia was 38 (range, 14-62) months. HPV types covered by the nonavalent HPV vaccination would potentially cover 94.8% of the development of lower genital tract dysplasia. Restricting the analysis to the 18 patients with available HPV data at the time of hysterectomy, the beneficial effect of nonvalent vaccination was 89%. However, considering that patients with persistent HPV types (with the same HPV types at the time of hysterectomy and who developed lower genital tract dysplasia) would not benefit from vaccination, we estimated the potential protective effect of vaccination to be 67% (12 out of 18 patients; four patients had a persistent infection for the same HPV type(s)).Conclusions: Our retrospective analysis supported the adoption of HPV vaccination in patients having treatment for HPV-related disease. Even in the absence of the uterine cervix, HPV vaccination would protect against develop lower genital tract dysplasia. Further prospective studies have to confirm our preliminary research.

Published
2024
Full Text
View/download PDF

30. Monitoring the activities of Italian colposcopy clinics before and during the COVID-19 pandemic

Author

Delli Carpini, Giovanni, Giorgi Rossi, Paolo, Giannella, Luca, Di Giuseppe, Jacopo, Clemente, Nicolò, Sopracordevole, Francesco, Barbero, Maggiorino, Bogani, Giorgio, De Vincenzo, Rosa Pasqualina, Origoni, Massimo, Cantatore, Francesco, Gardella, Barbara, Dominoni, Mattia, Monti, Ermelinda, Liverani, Carlo Antonio, Viscardi, Anna, Pagan, Alessio, Amadori, Andrea, Alessi, Chiara, Andolfatto, Matteo, Cattani, Paolo, Pieralli, Annalisa, Stevenazzi, Guido, Ciavattini, Andrea, De Vincenzo, Rosa (ORCID:0000-0001-7408-0435), Delli Carpini, Giovanni, Giorgi Rossi, Paolo, Giannella, Luca, Di Giuseppe, Jacopo, Clemente, Nicolò, Sopracordevole, Francesco, Barbero, Maggiorino, Bogani, Giorgio, De Vincenzo, Rosa Pasqualina, Origoni, Massimo, Cantatore, Francesco, Gardella, Barbara, Dominoni, Mattia, Monti, Ermelinda, Liverani, Carlo Antonio, Viscardi, Anna, Pagan, Alessio, Amadori, Andrea, Alessi, Chiara, Andolfatto, Matteo, Cattani, Paolo, Pieralli, Annalisa, Stevenazzi, Guido, Ciavattini, Andrea, and De Vincenzo, Rosa (ORCID:0000-0001-7408-0435)

Abstract

Objective: To evaluate the impact of healthcare reorganization during the severe acute respiratory syndrome coronavirus 2 pandemic on Italian colposcopy clinic activities, focusing on cervical excision procedures, follow-ups for conservative management of low-grade lesions, and follow-ups post cervical excision.Methods: Retrospective study conducted in 14 Italian colposcopy clinics. The number and clinical characteristics of cervical excisions, follow-ups for conservative management of low-grade lesions, and follow-ups after cervical excision were compared between the period March 1, 2019 to February 29, 2020 (pre-pandemic) and March 1, 2020 to February 28, 2021 (pandemic) with a Poisson regression analysis.Results: In the pandemic period, the number of cervical excisions was reduced by 8.8% (95% confidence interval [CI]=-15.6% to -2%; p=0.011). Excisions were less frequently performed in the operating room (-35.1%; 95% CI=-47.6% to -22.6%; p<0.001), the number of patients from spontaneous screening was reduced by -14.0% (95% CI=-23.4% to -4.6%; p=0.003), and the CO2-laser technique was used less frequently (-30%; 95% CI=-45.1% to -15.0%; p<0.001). As compared to the pre-pandemic period, the number of follow-ups for conservative management of low-grade lesions was reduced by -26.7% (95% CI=-39.0% to -14.4%; p<0.001), and the follow-up appointments after cervical excision were reduced by -51.0% (95% CI=-58.1% to -43.9%; p<0.001).Conclusion: The most significant impact of the healthcare reorganization during the coronavirus disease 2019 pandemic was on follow-ups after cervical excision. The resumption of disrupted activities should follow a risk-based prioritization, starting from women in follow-up after cervical excision. It is advisable that the trend of performing cervical excision as an outpatient procedure is maintained in the post-pandemic period.

Published
2023

31. Long-Term Follow-Up Outcomes in Women with In Situ/Microinvasive Adenocarcinoma of the Uterine Cervix Undergoing Conservative Treatment—Cervical Adenocarcinoma Study Group Italian Society of Colposcopy and Cervico-Vaginal Pathology.

Author

Giannella, Luca, Delli Carpini, Giovanni, Di Giuseppe, Jacopo, Grelloni, Camilla, Bogani, Giorgio, Dri, Marco, Sopracordevole, Francesco, Clemente, Nicolò, Giorda, Giorgio, De Vincenzo, Rosa, Evangelista, Maria Teresa, Gardella, Barbara, Dominoni, Mattia, Monti, Ermelinda, Alessi, Chiara, Alessandrini, Lara, Guerriero, Angela, Pagan, Alessio, Caretto, Marta, and Ghelardi, Alessandro

Subjects
ADENOCARCINOMA, CONSERVATIVE treatment, UTERINE tumors, CERVIX uteri tumors, CANCER invasiveness, VAGINA, LOGISTIC regression analysis, EVALUATION of medical care, TREATMENT effectiveness, RETROSPECTIVE studies, KAPLAN-Meier estimator, LOG-rank test, ODDS ratio, LONGITUDINAL method, COLPOSCOPY, RESEARCH methodology, WOMEN'S health, CONFIDENCE intervals, DATA analysis software, SURVIVAL analysis (Biometry), CARCINOMA in situ, PATIENT aftercare, CERVIX uteri
Abstract

Simple Summary: In situ/microinvasive adenocarcinoma of the uterine cervix represents the majority of cervical glandular lesions and can be treated conservatively. In contrast to squamous lesions, approximately 15–20% of glandular disease may be HPV-negative and therefore associated with a worse prognosis. Furthermore, up to 4% of cases may show recurrence after three years of follow-up. Given the abovementioned risk, knowing the predictive factors of disease recurrence becomes crucial for post-treatment management. In the present study, HPV testing in follow-up was the best predictor for recurrences in women with in situ/microinvasive AC undergoing conservative treatment. So, its use in clinical practice is of pivotal importance. However, attention should be paid to non-high-risk HPV women in follow-up with non-usual-type histopathology, given that it seems to represent a sub-population at increased risk of recurrences. Objective: The present study aimed to assess long-term follow-up outcomes in women with in situ/microinvasive adenocarcinoma (AC) of the uterine cervix treated conservatively. Methods: Retrospective multi-institutional study including women with early glandular lesions and 5-year follow-up undergoing fertility-sparing treatment. Independent variables associated with recurrence were evaluated. Logistic regression analysis and Kaplan–Meier survival analysis with Logrank test were performed. Results: Of 269 women diagnosed with in situ/microinvasive AC, 127 participants underwent conservative treatment. During follow-up, recurrences were found in nine women (7.1%). The only factor associated with recurrence during follow-up was positive high-risk Human Papillomavirus (hr-HPV) testing (odds ratio 6.21, confidence interval 1.47–26.08, p = 0.012). HPV positivity in follow-up showed a recurrence rate of 21.7% against 3.8% in patients who were HPV-negative (p = 0.002, Logrank test). Among women with negative high-risk HPV tests in follow-up, recurrences occurred in 20.0% of non-usual-type histology vs. 2.1% of usual-type cases (p = 0.005). Conclusion: HPV testing in follow-up is of pivotal importance in women with early glandular lesions undergoing conservative treatment, given its recurrence predictive value. However, women who are high-risk HPV-negative in follow-up with non-usual-type histopathology may represent a sub-population at increased risk of recurrences. Further studies should confirm these findings. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

32. Concurrent Endometrial Cancer in Women with Atypical Endometrial Hyperplasia: What Is the Predictive Value of Patient Characteristics? †.

Author

Giannella, Luca, Piva, Francesco, Delli Carpini, Giovanni, Di Giuseppe, Jacopo, Grelloni, Camilla, Giulietti, Matteo, Sopracordevole, Francesco, Giorda, Giorgio, Del Fabro, Anna, Clemente, Nicolò, Gardella, Barbara, Bogani, Giorgio, Brasile, Orsola, Martinello, Ruby, Caretto, Marta, Ghelardi, Alessandro, Albanesi, Gianluca, Stevenazzi, Guido, Venturini, Paolo, and Papiccio, Maria

Subjects
RESEARCH, HYSTERECTOMY, AGE distribution, UTERINE diseases, RETROSPECTIVE studies, REGRESSION analysis, DIABETES, ENDOMETRIAL tumors, SYMPTOMS, PREDICTION models, HISTOLOGY, ARTIFICIAL neural networks, RECEIVER operating characteristic curves, BODY mass index, COMORBIDITY, WOMEN'S health, DISEASE risk factors, EVALUATION
Abstract

Simple Summary: The rate of concurrent endometrial cancer (EC) in women with atypical endometrial hyperplasia (AEH) is not negligible. Furthermore, among women with EC, about 12% may have a high-risk disease requiring lymph node status assessment. Given that endometrial sampling cannot exclude EC in women with AEH, knowing variables that increase the risk of malignancy can be helpful in clinical practice. Some patient characteristics were associated with this occurrence, representing possible risk factors on which to adjust treatment planning. No prediction models with internal validation showed the impact of patient characteristics in predicting EC after a preoperative diagnosis of AEH. The present study, using regressions and artificial neural networks, found recurrent patient characteristics in women with EC. However, they likely do not contain good/optimal discriminating information. Future predictive models should include other individual factors (e.g., genotypic variables) to move toward more personalized medicine. Background: The rate of concurrent endometrial cancer (EC) in atypical endometrial hyperplasia (AEH) can be as high as 40%. Some patient characteristics showed associations with this occurrence. However, their real predictive power with related validation has yet to be discovered. The present study aimed to assess the performance of various models based on patient characteristics in predicting EC in women with AEH. Methods: This is a retrospective multi-institutional study including women with AEH undergoing definitive surgery. The women were divided according to the final histology (EC vs. no-EC). The available cases were divided into a training and validation set. Using k-fold cross-validation, we built many predictive models, including regressions and artificial neural networks (ANN). Results: A total of 193/629 women (30.7%) showed EC at hysterectomy. A total of 26/193 (13.4%) women showed high-risk EC. Regression and ANN models showed a prediction performance with a mean area under the curve of 0.65 and 0.75 on the validation set, respectively. Among the best prediction models, the most recurrent patient characteristics were age, body mass index, Lynch syndrome, diabetes, and previous breast cancer. None of these independent variables showed associations with high-risk diseases in women with EC. Conclusions: Patient characteristics did not show satisfactory performance in predicting EC in AEH. Risk stratification in AEH based mainly on patient characteristics may be clinically unsuitable. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

33. Colposcopy Accuracy and Diagnostic Performance: A Quality Control and Quality Assurance Survey in Italian Tertiary-Level Teaching and Academic Institutions—The Italian Society of Colposcopy and Cervico-Vaginal Pathology (SICPCV)

Author

Origoni, Massimo, primary, Cantatore, Francesco, additional, Sopracordevole, Francesco, additional, Clemente, Nicolò, additional, Spinillo, Arsenio, additional, Gardella, Barbara, additional, De Vincenzo, Rosa, additional, Ricci, Caterina, additional, Landoni, Fabio, additional, Di Meo, Maria Letizia, additional, Ciavattini, Andrea, additional, Di Giuseppe, Jacopo, additional, Preti, Eleonora, additional, Iacobone, Anna Daniela, additional, Carriero, Carmine, additional, Dellino, Miriam, additional, Capodanno, Massimo, additional, Perino, Antonino, additional, Miglioli, Cesare, additional, Insolia, Luca, additional, Barbero, Maggiorino, additional, and Candiani, Massimo, additional

Published
2023
Full Text
View/download PDF

34. In Situ/Microinvasive Adenocarcinoma of the Uterine Cervix and HPV-Type Impact: Pathologic Features, Treatment Options, and Follow-Up Outcomes—Cervical Adenocarcinoma Study Group (CAS-Group)

Author

Giannella, Luca, primary, Delli Carpini, Giovanni, additional, Di Giuseppe, Jacopo, additional, Bogani, Giorgio, additional, Sopracordevole, Francesco, additional, Clemente, Nicolò, additional, Giorda, Giorgio, additional, De Vincenzo, Rosa Pasqualina, additional, Evangelista, Maria Teresa, additional, Gardella, Barbara, additional, Dominoni, Mattia, additional, Monti, Ermelinda, additional, Alessi, Chiara, additional, Alessandrini, Lara, additional, Pagan, Alessio, additional, Caretto, Marta, additional, Ghelardi, Alessandro, additional, Amadori, Andrea, additional, Origoni, Massimo, additional, Barbero, Maggiorino, additional, Raspagliesi, Francesco, additional, Simoncini, Tommaso, additional, Vercellini, Paolo, additional, Scambia, Giovanni, additional, and Ciavattini, Andrea, additional

Published
2023
Full Text
View/download PDF

36. Outcomes of High-Grade Cervical Dysplasia with Positive Margins and HPV Persistence after Cervical Conization

Author

Giannini, Andrea, primary, Di Donato, Violante, additional, Sopracordevole, Francesco, additional, Ciavattini, Andrea, additional, Ghelardi, Alessandro, additional, Vizza, Enrico, additional, D’Oria, Ottavia, additional, Simoncini, Tommaso, additional, Plotti, Francesco, additional, Casarin, Jvan, additional, Golia D’Augè, Tullio, additional, Cuccu, Ilaria, additional, Serati, Maurizio, additional, Pinelli, Ciro, additional, Bergamini, Alice, additional, Gardella, Barbara, additional, Dell’Acqua, Andrea, additional, Monti, Ermelinda, additional, Vercellini, Paolo, additional, D’Ippolito, Giovanni, additional, Aguzzoli, Lorenzo, additional, Dario Mandato, Vincenzo, additional, Giannella, Luca, additional, Scaffa, Cono, additional, Ditto, Antonino, additional, Falcone, Francesca, additional, Borghi, Chiara, additional, Malzoni, Mario, additional, Di Giovanni, Alessandra, additional, Salerno, Maria Giovanna, additional, Liberale, Viola, additional, Contino, Biagio, additional, Donfrancesco, Cristina, additional, Desiato, Michele, additional, Perrone, Anna Myriam, additional, De Iaco, Pierandrea, additional, Ferrero, Simone, additional, Sarpietro, Giuseppe, additional, Matarazzo, Maria G., additional, Cianci, Antonio, additional, Cianci, Stefano, additional, Bosio, Sara, additional, Ruisi, Simona, additional, Mosca, Lavinia, additional, Tinelli, Raffaele, additional, De Vincenzo, Rosa, additional, Zannoni, Gian Franco, additional, Ferrandina, Gabriella, additional, Petrillo, Marco, additional, Capobianco, Giampiero, additional, Carlea, Annunziata, additional, Zullo, Fulvio, additional, Muschiato, Barbara, additional, Palomba, Stefano, additional, Greggi, Stefano, additional, Spinillo, Arsenio, additional, Ghezzi, Fabio, additional, Colacurci, Nicola, additional, Angioli, Roberto, additional, Benedetti Panici, Pierluigi, additional, Muzii, Ludovico, additional, Scambia, Giovanni, additional, Raspagliesi, Francesco, additional, and Bogani, Giorgio, additional

Published
2023
Full Text
View/download PDF

37. Extramammary Paget’s Disease of the Vulva and Concomitant Premalignant/Malignant Vulvar Lesions: A Potential Challenge in Diagnosis and Treatment

Author

Clemente, Nicolò, primary, Ciavattini, Andrea, additional, Valenti, Gaetano, additional, Zannier, Federica, additional, Di Giuseppe, Jacopo, additional, Delli Carpini, Giovanni, additional, Fichera, Mariasole, additional, Del Fabro, Anna, additional, Giorda, Giorgio, additional, Goteri, Gaia, additional, Canzonieri, Vincenzo, additional, and Sopracordevole, Francesco, additional

Published
2023
Full Text
View/download PDF

41. 2022-RA-733-ESGO Duration of HPV persistence and its relationship with recurrent cervical dysplasia

Author

Capalbo, Giuseppe, primary, Donato, Violante DI, additional, Sopracordevole, Francesco, additional, Ciavattini, Andrea, additional, Chiofalo, Benito, additional, Vizza, Enrico, additional, Vercellini, Paolo, additional, Ghezzi, Fabio, additional, Scambia, Giovanni, additional, Raspagliesi, Francesco, additional, Palaia, Innocenza, additional, Panici, Pierluigi Benedetti, additional, Muzii, Ludovico, additional, and Bogani, Giorgio, additional

Published
2022
Full Text
View/download PDF

47. Development of a Nomogram Predicting the Risk of Persistence/Recurrence of Cervical Dysplasia

Author

Bogani, Giorgio, Lalli, Luca, Sopracordevole, Francesco, Ciavattini, Andrea, Ghelardi, Alessandro, Simoncini, Tommaso, Plotti, Francesco, Casarin, Jvan, Serati, Maurizio, Pinelli, Ciro, Bergamini, Alice, Gardella, Barbara, Dell'Acqua, Andrea, Monti, Ermelinda, Vercellini, Paolo, Palaia, Innocenza, Perniola, Giorgia, Fischetti, Margherita, Santangelo, Giusi, Fracassi, Alice, D'Ippolito, Giovanni, Aguzzoli, Lorenzo, Mandato, Vincenzo Dario, Giannella, Luca, Scaffa, Cono, Falcone, Francesca, Borghi, Chiara, Malzoni, Mario, Giannini, Andrea, Salerno, Maria Giovanna, Liberale, Viola, Contino, Biagio, Donfrancesco, Cristina, Desiato, Michele, Perrone, Anna Myriam, Dondi, Giulia, De Iaco, Pierandrea, Ferrero, Simone, Sarpietro, Giuseppe, Matarazzo, Maria G, Cianci, Antonio, Cianci, Stefano, Bosio, Sara, Ruisi, Simona, Mosca, Lavinia, Tinelli, Raffaele, De Vincenzo, Rosa Pasqualina, Zannoni, Gian Franco, Ferrandina, Maria Gabriella, Petrillo, Marco, Capobianco, Giampiero, Dessiole, Salvatore, Carlea, Annunziata, Zullo, Fulvio, Muschiato, Barbara, Palomba, Stefano, Greggi, Stefano, Spinillo, Arsenio, Ghezzi, Fabio, Colacurci, Nicola, Angioli, Roberto, Benedetti Panici, Pierluigi, Muzii, Ludovico, Scambia, Giovanni, Raspagliesi, Francesco, Di Donato, Violante, De Vincenzo, Rosa (ORCID:0000-0001-7408-0435), Zannoni, Gian Franco (ORCID:0000-0003-1809-129X), Ferrandina, Gabriella (ORCID:0000-0003-4672-4197), Scambia, Giovanni (ORCID:0000-0003-2758-1063), Bogani, Giorgio, Lalli, Luca, Sopracordevole, Francesco, Ciavattini, Andrea, Ghelardi, Alessandro, Simoncini, Tommaso, Plotti, Francesco, Casarin, Jvan, Serati, Maurizio, Pinelli, Ciro, Bergamini, Alice, Gardella, Barbara, Dell'Acqua, Andrea, Monti, Ermelinda, Vercellini, Paolo, Palaia, Innocenza, Perniola, Giorgia, Fischetti, Margherita, Santangelo, Giusi, Fracassi, Alice, D'Ippolito, Giovanni, Aguzzoli, Lorenzo, Mandato, Vincenzo Dario, Giannella, Luca, Scaffa, Cono, Falcone, Francesca, Borghi, Chiara, Malzoni, Mario, Giannini, Andrea, Salerno, Maria Giovanna, Liberale, Viola, Contino, Biagio, Donfrancesco, Cristina, Desiato, Michele, Perrone, Anna Myriam, Dondi, Giulia, De Iaco, Pierandrea, Ferrero, Simone, Sarpietro, Giuseppe, Matarazzo, Maria G, Cianci, Antonio, Cianci, Stefano, Bosio, Sara, Ruisi, Simona, Mosca, Lavinia, Tinelli, Raffaele, De Vincenzo, Rosa Pasqualina, Zannoni, Gian Franco, Ferrandina, Maria Gabriella, Petrillo, Marco, Capobianco, Giampiero, Dessiole, Salvatore, Carlea, Annunziata, Zullo, Fulvio, Muschiato, Barbara, Palomba, Stefano, Greggi, Stefano, Spinillo, Arsenio, Ghezzi, Fabio, Colacurci, Nicola, Angioli, Roberto, Benedetti Panici, Pierluigi, Muzii, Ludovico, Scambia, Giovanni, Raspagliesi, Francesco, Di Donato, Violante, De Vincenzo, Rosa (ORCID:0000-0001-7408-0435), Zannoni, Gian Franco (ORCID:0000-0003-1809-129X), Ferrandina, Gabriella (ORCID:0000-0003-4672-4197), and Scambia, Giovanni (ORCID:0000-0003-2758-1063)

Abstract

Background: Cervical dysplasia persistence/recurrence has a great impact on women's health and quality of life. In this study, we investigated whether a prognostic nomogram may improve risk assessment after primary conization. Methods: This is a retrospective multi-institutional study based on charts of consecutive patients undergoing conization between 1 January 2010 and 31 December 2014. A nomogram assessing the importance of different variables was built. A cohort of patients treated between 1 January 2015 and 30 June 2016 was used to validate the nomogram. Results: A total of 2966 patients undergoing primary conization were analyzed. The median (range) patient age was 40 (18-89) years. At 5-year of follow-up, 6% of patients (175/2966) had developed a persistent/recurrent cervical dysplasia. Median (range) recurrence-free survival was 18 (5-52) months. Diagnosis of CIN3, presence of HR-HPV types, positive endocervical margins, HPV persistence, and the omission of HPV vaccination after conization increased significantly and independently of the risk of developing cervical dysplasia persistence/recurrence. A nomogram weighting the impact of all variables was built with a C-Index of 0.809. A dataset of 549 patients was used to validate the nomogram, with a C-index of 0.809. Conclusions: The present nomogram represents a useful tool for counseling women about their risk of persistence/recurrence after primary conization. HPV vaccination after conization is associated with a reduced risk of CIN2+.

Published
2022

48. Characteristics and patterns of care of endometrial cancer before and during COVID-19 pandemic

Author

Bogani, G, Scambia, G, Cimmino, C, Fanfani, F, Costantini, B, Loverro, M, Ferrandina, G, Landoni, F, Bazzurini, L, Grassi, T, Vitobello, D, Siesto, G, Perrone, A, Zanagnolo, V, De Iaco, P, Multinu, F, Ghezzi, F, Casarin, J, Berretta, R, Capozzi, V, Zupi, E, Centini, G, Pellegrino, A, Corso, S, Stevenazzi, G, Montoli, S, Boschi, A, Comerci, G, Greco, P, Martinello, R, Sopracordevole, F, Giorda, G, Simoncini, T, Caretto, M, Sartori, E, Ferrari, F, Cianci, A, Sarpietro, G, Matarazzo, M, Zullo, F, Bifulco, G, Morelli, M, Ferrero, A, Biglia, N, Barra, F, Ferrero, S, Leone Roberti Maggiore, U, Cianci, S, Chiantera, V, Ercoli, A, Sozzi, G, Martoccia, A, Schettini, S, Orlando, T, Cannone, F, Ettore, G, Puppo, A, Borghese, M, Martinelli, C, Muzii, L, Di Donato, V, Driul, L, Restaino, S, Bergamini, A, Candotti, G, Bocciolone, L, Plotti, F, Angioli, R, Mantovani, G, Ceccaroni, M, Cassani, C, Dominoni, M, Giambanco, L, Amodeo, S, Leo, L, Thomasset, R, Raimondo, D, Seracchioli, R, Malzoni, M, Gorlero, F, Di Luca, M, Busato, E, Kilzie, S, Dell'Acqua, A, Scarfone, G, Vercellini, P, Petrillo, M, Dessole, S, Capobianco, G, Ciavattini, A, Delli Carpini, G, Giannella, L, Mereu, L, Tateo, S, Sorbi, F, Fambrini, M, Cicogna, S, Romano, F, Ricci, G, Trojano, G, Consonni, R, Cantaluppi, S, Lippolis, A, Tinelli, R, D'Ippolito, G, Aguzzoli, L, Mandato, V, Palomba, S, Calandra, D, Rosati, M, Gallo, C, Surico, D, Remorgida, V, Ruscitto, F, Beretta, P, Benedetti Panici, P, Raspagliesi, F, Bogani, Giorgio, Scambia, Giovanni, Cimmino, Chiara, Fanfani, Francesco, Costantini, Barbara, Loverro, Matteo, Ferrandina, Gabriella, Landoni, Fabio, Bazzurini, Luca, Grassi, Tommaso, Vitobello, Domenico, Siesto, Gabriele, Perrone, Anna Myriam, Zanagnolo, Vanna, De Iaco, Pierandrea, Multinu, Francesco, Ghezzi, Fabio, Casarin, Jvan, Berretta, Roberto, Capozzi, Vito A, Zupi, Errico, Centini, Gabriele, Pellegrino, Antonio, Corso, Silvia, Stevenazzi, Guido, Montoli, Serena, Boschi, Anna Chiara, Comerci, Giuseppe, Greco, Pantaleo, Martinello, Ruby, Sopracordevole, Francesco, Giorda, Giorgio, Simoncini, Tommaso, Caretto, Marta, Sartori, Enrico, Ferrari, Federico, Cianci, Antonio, Sarpietro, Giuseppe, Matarazzo, Maria Grazia, Zullo, Fulvio, Bifulco, Giuseppe, Morelli, Michele, Ferrero, Annamaria, Biglia, Nicoletta, Barra, Fabio, Ferrero, Simone, Leone Roberti Maggiore, Umberto, Cianci, Stefano, Chiantera, Vito, Ercoli, Alfredo, Sozzi, Giulio, Martoccia, Angela, Schettini, Sergio, Orlando, Teresa, Cannone, Francesco G, Ettore, Giuseppe, Puppo, Andrea, Borghese, Martina, Martinelli, Canio, Muzii, Ludovico, Di Donato, Violante, Driul, Lorenza, Restaino, Stefano, Bergamini, Alice, Candotti, Giorgio, Bocciolone, Luca, Plotti, Francesco, Angioli, Roberto, Mantovani, Giulia, Ceccaroni, Marcello, Cassani, Chiara, Dominoni, Mattia, Giambanco, Laura, Amodeo, Silvia, Leo, Livio, Thomasset, Raphael, Raimondo, Diego, Seracchioli, Renato, Malzoni, Mario, Gorlero, Franco, Di Luca, Martina, Busato, Enrico, Kilzie, Sami, Dell'Acqua, Andrea, Scarfone, Giovanna, Vercellini, Paolo, Petrillo, Marco, Dessole, Salvatore, Capobianco, Giampiero, Ciavattini, Andrea, Delli Carpini, Giovanni, Giannella, Luca, Mereu, Liliana, Tateo, Saverio, Sorbi, Flavia, Fambrini, Massimiliano, Cicogna, Stefania, Romano, Federico, Ricci, Giuseppe, Trojano, Giuseppe, Consonni, Roberto, Cantaluppi, Simona, Lippolis, Antonio, Tinelli, Raffaele, D'Ippolito, Giovanni, Aguzzoli, Lorenzo, Mandato, Vincenzo D, Palomba, Stefano, Calandra, Davide, Rosati, Maurizio, Gallo, Cinzia, Surico, Daniela, Remorgida, Valentino, Ruscitto, Francesco, Beretta, Paolo, Benedetti Panici, Pierluigi, Raspagliesi, Francesco, Bogani, G, Scambia, G, Cimmino, C, Fanfani, F, Costantini, B, Loverro, M, Ferrandina, G, Landoni, F, Bazzurini, L, Grassi, T, Vitobello, D, Siesto, G, Perrone, A, Zanagnolo, V, De Iaco, P, Multinu, F, Ghezzi, F, Casarin, J, Berretta, R, Capozzi, V, Zupi, E, Centini, G, Pellegrino, A, Corso, S, Stevenazzi, G, Montoli, S, Boschi, A, Comerci, G, Greco, P, Martinello, R, Sopracordevole, F, Giorda, G, Simoncini, T, Caretto, M, Sartori, E, Ferrari, F, Cianci, A, Sarpietro, G, Matarazzo, M, Zullo, F, Bifulco, G, Morelli, M, Ferrero, A, Biglia, N, Barra, F, Ferrero, S, Leone Roberti Maggiore, U, Cianci, S, Chiantera, V, Ercoli, A, Sozzi, G, Martoccia, A, Schettini, S, Orlando, T, Cannone, F, Ettore, G, Puppo, A, Borghese, M, Martinelli, C, Muzii, L, Di Donato, V, Driul, L, Restaino, S, Bergamini, A, Candotti, G, Bocciolone, L, Plotti, F, Angioli, R, Mantovani, G, Ceccaroni, M, Cassani, C, Dominoni, M, Giambanco, L, Amodeo, S, Leo, L, Thomasset, R, Raimondo, D, Seracchioli, R, Malzoni, M, Gorlero, F, Di Luca, M, Busato, E, Kilzie, S, Dell'Acqua, A, Scarfone, G, Vercellini, P, Petrillo, M, Dessole, S, Capobianco, G, Ciavattini, A, Delli Carpini, G, Giannella, L, Mereu, L, Tateo, S, Sorbi, F, Fambrini, M, Cicogna, S, Romano, F, Ricci, G, Trojano, G, Consonni, R, Cantaluppi, S, Lippolis, A, Tinelli, R, D'Ippolito, G, Aguzzoli, L, Mandato, V, Palomba, S, Calandra, D, Rosati, M, Gallo, C, Surico, D, Remorgida, V, Ruscitto, F, Beretta, P, Benedetti Panici, P, Raspagliesi, F, Bogani, Giorgio, Scambia, Giovanni, Cimmino, Chiara, Fanfani, Francesco, Costantini, Barbara, Loverro, Matteo, Ferrandina, Gabriella, Landoni, Fabio, Bazzurini, Luca, Grassi, Tommaso, Vitobello, Domenico, Siesto, Gabriele, Perrone, Anna Myriam, Zanagnolo, Vanna, De Iaco, Pierandrea, Multinu, Francesco, Ghezzi, Fabio, Casarin, Jvan, Berretta, Roberto, Capozzi, Vito A, Zupi, Errico, Centini, Gabriele, Pellegrino, Antonio, Corso, Silvia, Stevenazzi, Guido, Montoli, Serena, Boschi, Anna Chiara, Comerci, Giuseppe, Greco, Pantaleo, Martinello, Ruby, Sopracordevole, Francesco, Giorda, Giorgio, Simoncini, Tommaso, Caretto, Marta, Sartori, Enrico, Ferrari, Federico, Cianci, Antonio, Sarpietro, Giuseppe, Matarazzo, Maria Grazia, Zullo, Fulvio, Bifulco, Giuseppe, Morelli, Michele, Ferrero, Annamaria, Biglia, Nicoletta, Barra, Fabio, Ferrero, Simone, Leone Roberti Maggiore, Umberto, Cianci, Stefano, Chiantera, Vito, Ercoli, Alfredo, Sozzi, Giulio, Martoccia, Angela, Schettini, Sergio, Orlando, Teresa, Cannone, Francesco G, Ettore, Giuseppe, Puppo, Andrea, Borghese, Martina, Martinelli, Canio, Muzii, Ludovico, Di Donato, Violante, Driul, Lorenza, Restaino, Stefano, Bergamini, Alice, Candotti, Giorgio, Bocciolone, Luca, Plotti, Francesco, Angioli, Roberto, Mantovani, Giulia, Ceccaroni, Marcello, Cassani, Chiara, Dominoni, Mattia, Giambanco, Laura, Amodeo, Silvia, Leo, Livio, Thomasset, Raphael, Raimondo, Diego, Seracchioli, Renato, Malzoni, Mario, Gorlero, Franco, Di Luca, Martina, Busato, Enrico, Kilzie, Sami, Dell'Acqua, Andrea, Scarfone, Giovanna, Vercellini, Paolo, Petrillo, Marco, Dessole, Salvatore, Capobianco, Giampiero, Ciavattini, Andrea, Delli Carpini, Giovanni, Giannella, Luca, Mereu, Liliana, Tateo, Saverio, Sorbi, Flavia, Fambrini, Massimiliano, Cicogna, Stefania, Romano, Federico, Ricci, Giuseppe, Trojano, Giuseppe, Consonni, Roberto, Cantaluppi, Simona, Lippolis, Antonio, Tinelli, Raffaele, D'Ippolito, Giovanni, Aguzzoli, Lorenzo, Mandato, Vincenzo D, Palomba, Stefano, Calandra, Davide, Rosati, Maurizio, Gallo, Cinzia, Surico, Daniela, Remorgida, Valentino, Ruscitto, Francesco, Beretta, Paolo, Benedetti Panici, Pierluigi, and Raspagliesi, Francesco

Abstract

Objective: Coronavirus disease 2019 (COVID-19) outbreak has correlated with the disruption of screening activities and diagnostic assessments. Endometrial cancer (EC) is one of the most common gynecological malignancies and it is often detected at an early stage, because it frequently produces symptoms. Here, we aim to investigate the impact of COVID-19 outbreak on patterns of presentation and treatment of EC patients. Methods: This is a retrospective study involving 54 centers in Italy. We evaluated patterns of presentation and treatment of EC patients before (period 1: March 1, 2019 to February 29, 2020) and during (period 2: April 1, 2020 to March 31, 2021) the COVID-19 outbreak. Results: Medical records of 5,164 EC patients have been retrieved: 2,718 and 2,446 women treated in period 1 and period 2, respectively. Surgery was the mainstay of treatment in both periods (p=0.356). Nodal assessment was omitted in 689 (27.3%) and 484 (21.2%) patients treated in period 1 and 2, respectively (p<0.001). While, the prevalence of patients undergoing sentinel node mapping (with or without backup lymphadenectomy) has increased during the COVID-19 pandemic (46.7% in period 1 vs. 52.8% in period 2; p<0.001). Overall, 1,280 (50.4%) and 1,021 (44.7%) patients had no adjuvant therapy in period 1 and 2, respectively (p<0.001). Adjuvant therapy use has increased during COVID-19 pandemic (p<0.001). Conclusion: Our data suggest that the COVID-19 pandemic had a significant impact on the characteristics and patterns of care of EC patients. These findings highlight the need to implement healthcare services during the pandemic.

Published
2022

50. Development of a Nomogram Predicting the Risk of Persistence/Recurrence of Cervical Dysplasia

Author

Bogani, Giorgio, primary, Lalli, Luca, additional, Sopracordevole, Francesco, additional, Ciavattini, Andrea, additional, Ghelardi, Alessandro, additional, Simoncini, Tommaso, additional, Plotti, Francesco, additional, Casarin, Jvan, additional, Serati, Maurizio, additional, Pinelli, Ciro, additional, Bergamini, Alice, additional, Gardella, Barbara, additional, Dell’Acqua, Andrea, additional, Monti, Ermelinda, additional, Vercellini, Paolo, additional, Palaia, Innocenza, additional, Perniola, Giorgia, additional, Fischetti, Margherita, additional, Santangelo, Giusi, additional, Fracassi, Alice, additional, D’Ippolito, Giovanni, additional, Aguzzoli, Lorenzo, additional, Mandato, Vincenzo Dario, additional, Giannella, Luca, additional, Scaffa, Cono, additional, Falcone, Francesca, additional, Borghi, Chiara, additional, Malzoni, Mario, additional, Giannini, Andrea, additional, Salerno, Maria Giovanna, additional, Liberale, Viola, additional, Contino, Biagio, additional, Donfrancesco, Cristina, additional, Desiato, Michele, additional, Perrone, Anna Myriam, additional, Dondi, Giulia, additional, De Iaco, Pierandrea, additional, Ferrero, Simone, additional, Sarpietro, Giuseppe, additional, Matarazzo, Maria G., additional, Cianci, Antonio, additional, Cianci, Stefano, additional, Bosio, Sara, additional, Ruisi, Simona, additional, Mosca, Lavinia, additional, Tinelli, Raffaele, additional, De Vincenzo, Rosa, additional, Zannoni, Gian Franco, additional, Ferrandina, Gabriella, additional, Petrillo, Marco, additional, Capobianco, Giampiero, additional, Dessiole, Salvatore, additional, Carlea, Annunziata, additional, Zullo, Fulvio, additional, Muschiato, Barbara, additional, Palomba, Stefano, additional, Greggi, Stefano, additional, Spinillo, Arsenio, additional, Ghezzi, Fabio, additional, Colacurci, Nicola, additional, Angioli, Roberto, additional, Benedetti Panici, Pierluigi, additional, Muzii, Ludovico, additional, Scambia, Giovanni, additional, Raspagliesi, Francesco, additional, and Di Donato, Violante, additional

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results