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153 results on '"Su, Yanhong"'

6. Zfp335 establishes eTreg lineage and neonatal immune tolerance by targeting Hadha-mediated fatty acid oxidation

Author

Wang, Xin, Sun, Lina, Yang, Biao, Li, Wenhua, Zhang, Cangang, Yang, Xiaofeng, Sun, Yae, Shen, Xiaonan, Gao, Yang, Ju, Bomiao, Gao, Yafeng, Liu, Dan, Song, Jiapeng, Jia, Xiaoxuan, Su, Yanhong, Jiao, Anjun, Liu, Haiyan, Zhang, Lianjun, He, Lan, Lei, Lei, Chen, WanJun, and Zhang, Baojun

Subjects
T cells -- Analysis, Inflammation -- Analysis, Autoimmunity -- Analysis, B cells -- Analysis, Fatty acids -- Analysis, Enzymes -- Analysis, Infants (Newborn) -- Analysis, Oxidation-reduction reaction -- Analysis, Health care industry
Abstract

Regulatory T cells (Tregs) are instrumental in maintaining immune tolerance and preventing destructive autoimmunity, but how heterogeneous Treg populations are established remains largely unknown. Here, we show that Zfp335 deletion in Tregs failed to differentiate into effector Tregs (eTregs) and lose Treg-suppressive function and that KO mice exhibited early-onset lethal autoimmune inflammation with unrestricted activation of conventional T cells. Single-cell RNASeq analyses revealed that Zfp335-deficient Tregs lacked a eTreg population and showed dramatic accumulation of a dysfunctional Treg subset. Mechanistically, Zfp335-deficient Tregs displayed reduced oxidative phosphorylation and dysfunctional mitochondrial activity. Further studies revealed that Zfp335 controlled eTreg differentiation by regulating fatty acid oxidation (FAO) through direct targeting of the FAO enzyme Hadha. Importantly, we demonstrate a positive correlation between ZNF335 and HADHA expression in human eTregs. Our findings reveal that Zfp335 controls FAO-driven eTreg differentiation to establish immune tolerance., Introduction Regulatory T cells (Tregs) expressing forkhead box P3 (Foxp3) play a key role in the establishment and maintenance of peripheral immune tolerance through the prevention and suppression of autoimmunity [...]

Published
2023
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8. The Transcription Factor Zfp335 Promotes Differentiation and Survival of Effector Th1 Cells by Directly Regulating Lmna Expression

Author

Liu, Haiyan, primary, Feng, Zhao, additional, Jiao, Anjun, additional, Lan, Linbo, additional, Ding, Renyi, additional, Li, Wenhua, additional, Zheng, Huiqiang, additional, Su, Yanhong, additional, Jia, Xiaoxuan, additional, Zhang, Dan, additional, Yang, Xiaofeng, additional, Zhang, Lianjun, additional, Sun, Lina, additional, and Zhang, Baojun, additional

Published
2024
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13. A comparative study of the in vitro antitumor effect of the disulfide-linked and diselenide-linked polyethylene glycol-curcumin nanoparticles.

Author

Zhou, Mengting, Xu, Qingbo, Liu, Jiangfei, Zhu, Tianyu, Su, Yanhong, Chu, Jing, Cao, Huaibao, Hu, Hang, and Xu, Defeng

Subjects
CURCUMIN, TURMERIC, NANOPARTICLES, POLYETHYLENE, CYTOTOXINS, COLLOIDAL stability, IN vitro studies, CURCUMINOIDS, DISULFIDES
Abstract

Curcumin (CUR) is a natural compound extracted from turmeric (Curcuma longa), which has been reported to be a promising anti-cancer drug in various cancers. However, poor water solubility and low bioavailability posed a challenge for clinical application of curcumin. In this work, four CUR prodrugs, namely PEG4000-SS-CUR, PEG1500-SS-CUR, PEG4000-SeSe-CUR and PEG1500-SeSe-CUR were synthesized. These four CUR prodrugs have high CUR loading content and can self-assemble into spherical nanoparticles (NPs) with particle size of 90–190 nm in aqueous solution. The four CUR prodrug NPs exhibit good colloidal stability in PBS buffer and promoted drug release in response to GSH. Due to the enhanced water solubility, the four CUR prodrug NPs all exhibit reduced cellular uptake amount as compared to CUR in in vitro cellular uptake study. The four CUR prodrug NPs exhibit similar cytotoxicity against 22Rv1 cells as compared to free CUR while PEG4000-SeSe-CUR NPs exhibit the highest cytotoxicity and induce the highest cell apoptosis ratio against 4T1 cells in in vitro antitumor effect study. PEG4000-SeSe-CUR NPs developed in this work were proven to be an effective nanoformulation of CUR against 4T1 cells. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Single-cell sequencing reveals the evolution of immune molecules across multiple vertebrate species

Author

Jiao, Anjun, primary, Zhang, Cangang, additional, Wang, Xin, additional, Sun, Lina, additional, Liu, Haiyan, additional, Su, Yanhong, additional, Lei, Lei, additional, Li, Wenhua, additional, Ding, Renyi, additional, Ding, Chenguang, additional, Dou, Meng, additional, Tian, Puxun, additional, Sun, Chenming, additional, Yang, Xiaofeng, additional, Zhang, Lianjun, additional, and Zhang, Baojun, additional

Published
2023
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23. Cuproptosis‐Driven Enhancement of Thermotherapy by Sequentially Response Cu2‐xSe via Copper Chemical Transition.

Author

Chan, Leung, Liu, Yongkang, Chen, Muhe, Su, Yanhong, Guo, Junxian, Zhu, Liwen, Zhan, Meixiao, Chen, Tianfeng, and Lu, Ligong

Subjects
THERMOTHERAPY, MALEIC anhydride, REACTIVE oxygen species, TUMOR treatment, TRICARBOXYLIC acids, SEMIMETALS, COPPER
Abstract

Activation of cuproptosis pathway has been reported to hold great potential in the application of tumor treatment. But the efficacy of cuproptosis seriously limited by the insufficient accumulation in the tumor sites. Therefore, herein based on the strong stabilization effects of the metalloid element selenium (Se) on copper (Cu), a photothermic Cu2‐xSe nanoparticle encapsulated with bioresponsive dimethyl maleic anhydride (DMMA@Cu2‐xSe) as a copper‐carrier to improve the copper accumulation in tumor is constructed, thus achieving cuproptosis‐driven enhancement of thermotherapy. This nanosystem exhibits the enhancement of tumor cellular uptake by a weak acid‐triggered charge‐switching ability. Next step, the exposed Cu2‐xSe is oxidized and releases divalent copper by high‐level oxide. Then, the abundant copper induces more dihydrolipoamide S‐acetyltransferase oligomerization to down‐regulate FDX1 and tricarboxylic acid cycle‐related proteins, which leads to inhibiting aerobic respiration. Cuproptosis‐induced mitochondrial damage further improves thermotherapy by up‐regulating reactive oxygen species (ROS). In addition, the generated ROS also promotes copper release to strengthen cuproptosis, and eventually improves tumor thermotherapy in turn. In general, DMMA@Cu2‐xSe with sequentially triggered copper‐release, efficient cuproptosis, and appropriate photothermal is a self‐enhanced nanoplatform for cuproptosis‐driven enhancement of thermotherapy. [ABSTRACT FROM AUTHOR]

Published
2023
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25. A comparative study of the in vitro antitumor effect of the disulfide-linked and diselenide-linked polyethylene glycol-curcumin nanoparticles

Author

Zhou, Mengting, Xu, Qingbo, Liu, Jiangfei, Zhu, Tianyu, Su, Yanhong, Chu, Jing, Cao, Huaibao, Hu, Hang, and Xu, Defeng

Abstract

Curcumin (CUR) is a natural compound extracted from turmeric (Curcuma longa), which has been reported to be a promising anti-cancer drug in various cancers. However, poor water solubility and low bioavailability posed a challenge for clinical application of curcumin. In this work, four CUR prodrugs, namely PEG4000-SS-CUR, PEG1500-SS-CUR, PEG4000-SeSe-CUR and PEG1500-SeSe-CUR were synthesized. These four CUR prodrugs have high CUR loading content and can self-assemble into spherical nanoparticles (NPs) with particle size of 90–190 nm in aqueous solution. The four CUR prodrug NPs exhibit good colloidal stability in PBS buffer and promoted drug release in response to GSH. Due to the enhanced water solubility, the four CUR prodrug NPs all exhibit reduced cellular uptake amount as compared to CUR in in vitro cellular uptake study. The four CUR prodrug NPs exhibit similar cytotoxicity against 22Rv1 cells as compared to free CUR while PEG4000-SeSe-CUR NPs exhibit the highest cytotoxicity and induce the highest cell apoptosis ratio against 4T1 cells in in vitro antitumor effect study. PEG4000-SeSe-CUR NPs developed in this work were proven to be an effective nanoformulation of CUR against 4T1 cells.

Published
2023
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29. The Transcription Factor Zfp335 Promotes Differentiation and Persistence of Memory CD8+ T Cells by Regulating TCF-1

Author

Liu, Haiyan, primary, Wang, Xin, additional, Ding, Renyi, additional, Jiao, Anjun, additional, Zheng, Huiqiang, additional, Zhang, Cangang, additional, Feng, Zhao, additional, Su, Yanhong, additional, Yang, Xiaofeng, additional, Lei, Lei, additional, Sun, Lina, additional, Zhang, Lianjun, additional, Sun, Chenming, additional, and Zhang, Baojun, additional

Published
2022
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30. Med1 Controls Effector CD8+ T Cell Differentiation and Survival through C/EBPβ-Mediated Transcriptional Control of T-bet

Author

Jiao, Anjun, primary, Liu, Haiyan, additional, Ding, Renyi, additional, Zheng, Huiqiang, additional, Zhang, Cangang, additional, Feng, Zhao, additional, Lei, Lei, additional, Wang, Xin, additional, Su, Yanhong, additional, Yang, Xiaofeng, additional, Sun, Chenming, additional, Zhang, Lianjun, additional, Bai, Liang, additional, Sun, Lina, additional, and Zhang, Baojun, additional

Published
2022
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33. Integrative multi-omics analysis reveals molecular subtypes and tumor evolution of synovial sarcoma

Author

Chen, Yi, primary, Su, Yanhong, additional, Leo, Isabelle Rose, additional, Siavelis, Ioannis, additional, Zeng, Jianming, additional, Cao, Xiaofang, additional, Tsagkozis, Panagiotis, additional, Hesla, Asle C, additional, Papakonstantinou, Andri, additional, Liu, Xiao, additional, Huang, Wen-Kuan, additional, Ehnman, Monika, additional, Johansson, Henrik, additional, Lin, Yingbo, additional, Lehtiö, Janne, additional, Zhang, Yifan, additional, Larsson, Olle, additional, and Haglund de Flon, Felix, additional

Published
2022
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34. DExD/H-box helicase 9 intrinsically controls CD8 + T cell–mediated antiviral response through noncanonical mechanisms

Author

Jiao, Anjun, primary, Sun, Chenming, additional, Wang, Xin, additional, Lei, Lei, additional, Liu, Haiyan, additional, Li, Wenhui, additional, Yang, Xiaofeng, additional, Zheng, Huiqiang, additional, Ding, Renyi, additional, Zhu, Kun, additional, Su, Yanhong, additional, Zhang, Cangang, additional, Zhang, Lianjun, additional, and Zhang, Baojun, additional

Published
2022
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37. A Multi-Target and Multi-Channel Mechanism of Action for Jiawei Yinhuo Tang in the Treatment of Social Communication Disorders in Autism: Network Pharmacology and Molecular Docking Studies

Author

Zhang Linlin, Lai Ciai, Su Yanhong, Gan Huizhong, Li Yongchun, Yang Zhen, Xu Shan, Gong Fengying, Lv Ying, Li Jingjun, and Fan Qin

Subjects
Complementary and alternative medicine, Article Subject
Abstract

Background. Autism spectrum disorder (ASD) is a highly heterogeneous neurodevelopmental disorder with complex pathogenesis. Currently, the pathogenesis of ASD is not fully understood. Moreover, current treatments do not effectively alleviate the primary symptoms of ASD social disorder (SCDA). Jiawei Yinhuo Tang (JWYHT) is an improved version of the classic prescription Yinhuo Tang. Although this medication has been shown to improve social behavior in ASD patients, the mechanism by which it works remains unknown. Methods. In this study, network pharmacology bioinformatics analysis was used to identify the key targets, biological functions, and signal pathways of JWYHT in SCDA. Then, molecular docking and molecular dynamic simulation were used to validate the activity and stability of the active ingredient and the target protein during the binding process. Results. The analysis identified 157 key targets and 9 core targets of JWYHT (including proto-oncogene (FOS), caspase 3 (CASP3), mitogen-activated protein kinase-3 (MAPK3), interleukin-6 (IL6), mitogen-activated protein kinase-1 (MAPK1), tumor necrosis factor (TNF), mitogen-activated protein kinase-8 (MAPK8), AKT serine/threonine kinase 1 (AKT1), and 5-hydroxytryptamine receptor 1B (5HT1B)) in SCDA. In addition, the Kyoto Encyclopedia of Gene and Genome results, as well as the staggering network analyses, revealed 20 biological processes and 20 signal pathways targeted by JWYHT in SCDA. Finally, molecular docking analysis was used to determine the binding activity of the main active components of JWYHT to the key targets. The binding activity and stability of methyl arachidonate and MAPK8 were demonstrated using molecular dynamics simulation. Conclusion. This study demonstrates that JWYHT regulates neuronal development, synaptic transmission, intestinal and cerebral inflammatory response, and other processes in SCDA.

Published
2022
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39. Arid1a promotes thymocyte development through β‐selection‐dependent and β‐selection‐independent mechanisms

Author

Yang, Xiaofeng, primary, Wang, Xin, additional, Lei, Lei, additional, Su, Yanhong, additional, Zou, Yujing, additional, Liu, Haiyan, additional, Jiao, Anjun, additional, Zhang, Cangang, additional, Liu, Jun, additional, Li, Wenhua, additional, Ding, Renyi, additional, Zhou, Xiaobo, additional, Shi, Lin, additional, Zhang, Dan, additional, Sun, Chenming, additional, and Zhang, Baojun, additional

Published
2021
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41. Single-cell sequencing reveals antitumor characteristics of intratumoral immune cells in old mice

Author

Zhang, Cangang, primary, Lei, Lei, additional, Yang, Xiaofeng, additional, Ma, Kaili, additional, Zheng, Huiqiang, additional, Su, Yanhong, additional, Jiao, Anjun, additional, Wang, Xin, additional, Liu, Haiyan, additional, Zou, Yujing, additional, Shi, Lin, additional, Zhou, Xiaobo, additional, Sun, Chenming, additional, Hou, Yuzhu, additional, Xiao, Zhengtao, additional, Zhang, Lianjun, additional, and Zhang, Baojun, additional

Published
2021
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42. C118P, a novel microtubule inhibitor with anti-angiogenic and vascular disrupting activities, exerts anti-tumor effects against hepatocellular carcinoma

Author

Yang, Mei, primary, Su, Yanhong, additional, Wang, Zhiqiang, additional, Du, Danyu, additional, Wei, Shihui, additional, Liao, Zhengguang, additional, Zhang, Qian, additional, Zhao, Liwen, additional, Zhang, Xian, additional, Han, Luwei, additional, Jiang, Jingwei, additional, Zhan, Meixiao, additional, Sun, Li, additional, Yuan, Shengtao, additional, and Zhou, Zhiling, additional

Published
2021
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45. Analysis of the clinical characteristics of dabigatran-induced oesophagitis

Author

Zhou, Yulu, Su, Yanhong, Li, Zuojun, Wu, Cuifang, Sun, Wei, and Wang, Chunjiang

Abstract

ObjectivesDabigatran-induced oesophagitis has emerged in recent years. However, the incidence and clinical characteristics of patients with dabigatran-induced oesophagitis have not yet been clarified. The aim of this study was to examine the clinical characteristics of the disease.MethodsA retrospective analysis was undertaken of the literature on dabigatran-induced oesophagitis in Chinese and English from 2008 onwards.ResultsThere were 20 men (74.07%) and seven women (25.93%) in the study; their median age was 75 years (range 37–90). The main clinical symptoms were dysphagia (42.31%), odynophagia (26.92%), retrosternal pain (23.08%) and heartburn (23.08%). Endoscopy mainly showed sloughing mucosal casts (14 cases, 56%), ulcers (8 cases, 32%) and erosion (6 cases, 24%). The main injury sites were the mid to lower oesophagus (32%) and the mid oesophagus (32%). Withdrawal of dabigatran or giving the correct medication regimen resulted in rapid recovery of clinical symptoms from 1 day in some patients and up to 4 weeks, and mucosal recovery (2–5 weeks) in a median time of 3 weeks (range 0.29–48) in all patients.ConclusionsOesophagitis is a rare complication of dabigatran with a good prognosis. Patients should be given proper medication instructions to prevent the occurrence of dabigatran-induced oesophagitis.

Published
2023
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47. Med1 controls CD8 T cell maintenance through IL‐7R‐mediated cell survival signalling

Author

Lei, Lei, primary, Yang, Xiaofeng, additional, Su, Yanhong, additional, Zheng, Huiqiang, additional, Liu, Jun, additional, Liu, Haiyan, additional, Zou, Yujing, additional, Jiao, Anjun, additional, Wang, Xin, additional, Zhang, Cangang, additional, Zhang, Xingzhe, additional, Zhang, Jiahui, additional, Zhang, Dan, additional, Zhou, Xiaobo, additional, Shi, Lin, additional, Liu, Enqi, additional, Bai, Liang, additional, Sun, Chenming, additional, and Zhang, Baojun, additional

Published
2021
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48. A Genetic Model Reveals Biological Features of Neonatal CD4 Helper Cells Undergone Homeostasis in Mice

Author

Lei, Lei, primary, Zhang, Xingzhe, additional, Yang, Xiaofeng, additional, Su, Yanhong, additional, Liu, Haiyan, additional, Yang, Hang, additional, Wang, Jinli, additional, Zou, Yujing, additional, Wang, Xin, additional, Jiao, Anjun, additional, Zhang, Cangang, additional, Zheng, Huiqiang, additional, Zhang, Jiahui, additional, Zhang, Dan, additional, Shi, Lin, additional, Zhou, Xiaobo, additional, Sun, Chenming, additional, and Zhang, Baojun, additional

Published
2021
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49. CD11c-CD8 Spatial Cross Presentation: A Novel Approach to Link Immune Surveillance and Patient Survival in Soft Tissue Sarcoma

Author

Su, Yanhong, primary, Tsagkozis, Panagiotis, additional, Papakonstantinou, Andri, additional, Tobin, Nicholas P., additional, Gultekin, Okan, additional, Malmerfelt, Anna, additional, Ingelshed, Katrine, additional, Neo, Shi Yong, additional, Lundquist, Johanna, additional, Chaabane, Wiem, additional, Nisancioglu, Maya H., additional, Leiss, Lina W., additional, Östman, Arne, additional, Bergh, Jonas, additional, Sedimbi, Saikiran, additional, Lehti, Kaisa, additional, Lundqvist, Andreas, additional, Stragliotto, Christina L., additional, Haglund, Felix, additional, and Ehnman, Monika, additional

Published
2021
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50. Single-cell sequencing characterizes intratumoral profile of immune cells in old mice

Author

Zhang, Cangang, primary, Lei, Lei, additional, Yang, Xiaofeng, additional, Zheng, Huiqiang, additional, Su, Yanhong, additional, Jiao, Anjun, additional, Wang, Xin, additional, Liu, Haiyan, additional, Zou, Yujing, additional, Shi, Lin, additional, Zhou, Xiaobo, additional, Sun, Chenming, additional, Zhang, Lianjun, additional, Hou, Yuzhu, additional, Xiao, Zhengtao, additional, and Zhang, Baojun, additional

Published
2021
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