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2 results on '"Svetlana O. Andryushkevich"'

1. The first synthesis and molecular docking studies of diastereomerically pure substituted 4-amino-7-hydroxyheptanoic acids

Author

Ghermes G. Chilov, Igor V. Svitanko, Sema L. Ioffe, Alexey Yu. Sukhorukov, Svetlana O. Andryushkevich, and Alexey A. Zeifman

Subjects
chemistry.chemical_classification, chemistry.chemical_compound, GABA transaminase, Enzyme, chemistry, Nitroethane, General Chemistry, Combinatorial chemistry, Amino acid
Abstract

Diastereoselective synthesis of 4-amino-7-hydroxyheptanoic acids 1 , new GABA analogues, was performed involving reduction of C-3 functionalized 5,6-dihydro-4 H -1,2-oxazines available from nitroethane. Molecular docking studies showed that amino acids of type 1 may bind to GABA transaminase, however, no inhibition was observed in the experiments with the enzyme.

Published
2011
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2. ChemInform Abstract: The First Synthesis and Molecular Docking Studies of Diastereomerically Pure Substituted 4-Amino-7-hydroxyheptanoic Acids

Author

Alexey A. Zeifman, Ghermes G. Chilov, Alexey Yu. Sukhorukov, Svetlana O. Andryushkevich, Sema L. Ioffe, and Igor V. Svitanko

Subjects
chemistry.chemical_classification, chemistry.chemical_compound, GABA transaminase, Enzyme, chemistry, Stereochemistry, Nitroethane, General Medicine, Amino acid
Abstract

Diastereoselective synthesis of 4-amino-7-hydroxyheptanoic acids 1 , new GABA analogues, was performed involving reduction of C-3 functionalized 5,6-dihydro-4 H -1,2-oxazines available from nitroethane. Molecular docking studies showed that amino acids of type 1 may bind to GABA transaminase, however, no inhibition was observed in the experiments with the enzyme.

Published
2011
Full Text
View/download PDF

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