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Your search keyword '"Sylvie Coslédan"' showing total 2 results
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2 results on '"Sylvie Coslédan"'

1. Identification of Potential Extractables and Leachables in Cosmetic Plastic Packaging by Microchambers-Thermal Extraction and Pyrolysis-Gas Chromatography-Mass Spectrometry

Author

Pauline Murat, Sowmya Harohalli Puttaswamy, Pierre-Jacques Ferret, Sylvie Coslédan, and Valérie Simon

Subjects
volatile and semi-volatile compounds, migration, plastic packaging, emission, thermal extraction, green analytical chemistry, Organic chemistry, QD241-441
Abstract

Most container–content interaction studies are carried out through migration tests on end products or simulants involving generally toxic solvents. This study was conducted with the aim of identifying potential leachables from materials used in cosmetic plastic packaging by using two approaches based on solvent-free extraction, i.e., solid-phase microextraction sampling and pyrolyzer/thermal desorption coupled with gas chromatography mass spectrometry. Volatile and semi-volatile intentionally and non-intentionally added substances were detected in seven packaging samples made of polypropylene, polyethylene, and styrene-acrylonitrile copolymer. Thirty-five compounds related to the polymers industry or packaging industry were identified, among them phthalates, alkanes, styrene, and cyanide derivates including degradation products, impurities, additives, plasticizers, and monomers. All except eight belong to the Cramer class I. These thermodesorption techniques are complementary to those used for migration tests.

Published
2020
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2. Assessment of targeted non-intentionally added substances in cosmetics in contact with plastic packagings. Analytical and toxicological aspects

Author

Pauline Murat, Sylvie Coslédan, Pierre-Jacques Ferret, Valérie Simon, Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE), Institut National de la Recherche Agronomique - INRA (FRANCE), Laboratoires Pierre Fabre (FRANCE), Laboratoire de Chimie Agro-Industrielle - LCA (Toulouse, France), Laboratoires Pierre Fabre, Laboratoire de Chimie Agro-Industrielle (LCA), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Supérieure de Chimie de Toulouse, Chimie Agro-Industrielle (CAI), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole nationale supérieure des ingénieurs en arts chimiques et technologiques-Institut National de la Recherche Agronomique (INRA), Centre de Recherche Pierre Fabre, and Institut National Polytechnique de Toulouse - INPT (FRANCE)

Subjects
Bisphenol A, media_common.quotation_subject, Container-content interactions, Phthalic Acids, Cosmetics, Toxicology, Consumer safety, 03 medical and health sciences, chemistry.chemical_compound, 0404 agricultural biotechnology, Phenols, Limit of Detection, [SDV.IDA]Life Sciences [q-bio]/Food engineering, Benzhydryl Compounds, 030304 developmental biology, media_common, 0303 health sciences, Chemistry, Reproducibility of Results, 04 agricultural and veterinary sciences, General Medicine, Diisobutyl phthalate, Contamination, [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences, Non-intentionally added substances, Pulp and paper industry, 040401 food science, Packaging, Safety assessment, [SDV.TOX]Life Sciences [q-bio]/Toxicology, Gas chromatography-mass spectrometry, Sciences pharmaceutiques, Cosmetic industry, Plastics, Food Science
Abstract

International audience; Container-content interactions are common in the food and pharmaceutical industries. However, these studies are more complicated in the cosmetic industry, and it is necessary to ensure consumer safety. The objective of this work was to develop a strategy for the toxicological evaluation of leachables for cosmetic packagings. Eleven common plastic packagings were selected to evaluate interactions with 5 simulants (acidic, alkaline and neutral water, 30% and 96% ethanol) chosen to mimic cosmetics behavior. A GC-MS method was developed to screen for 12 non-intentionally added substances of particular concern: 10 phthalates, bisphenol A and distearyl thiodipropionate (European Pharmacopoeia plastic additive 17). Results were analyzed using a toxicological procedure established for this study. Some phthalates and bisphenol A were detected in several samples, but only one contaminant, diisobutyl phthalate (DiBP), was found to be above the set concentration threshold. Using toxicological data, this concentration was found to be safe for users. 96% ethanol appeared to be the strongest simulant in term of extraction, with a maximum concentration of 491 μg/L for DiBP in a 100% styrene-acrylonitrile copolymer packaging. In water simulants, less contaminants were extracted, with concentrations under 20 μg/L.

Published
2018
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