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1. Indirect evidence for elemental hydrogen in laser-compressed hydrocarbons

Author

D. Kraus, J. Vorberger, N. J. Hartley, J. Lütgert, M. Rödel, D. Chekrygina, T. Döppner, T. van Driel, R. W. Falcone, L. B. Fletcher, S. Frydrych, E. Galtier, D. O. Gericke, S. H. Glenzer, E. Granados, Y. Inubushi, N. Kamimura, K. Katagiri, M. J. MacDonald, A. J. MacKinnon, T. Matsuoka, K. Miyanishi, E. E. McBride, I. Nam, P. Neumayer, N. Ozaki, A. Pak, A. Ravasio, A. M. Saunders, A. K. Schuster, M. G. Stevenson, K. Sueda, P. Sun, T. Togashi, K. Voigt, M. Yabashi, and T. Yabuuchi

Subjects
Physics, QC1-999
Abstract

We demonstrate a significantly simplified experimental approach for investigating liquid metallic hydrogen, which is crucial to understand the internal structure and evolution of giant planets. Plastic samples were shockcompressed and then probed by short pulses of X-rays generated by free electron lasers. By comparison with ab initio simulations, we provide indirect evidence for the creation of elemental hydrogen in shock-compressed plastics at ∼150GPa and ∼5,000K and thus in a regime where hydrogen is predicted to be metallic. Being the most common form of condensed matter in our solar system, and ostensibly the simplest of all elements, hydrogen is the model case for many theoretical studies and we provide a new possibility to benchmark models for conditions with extreme pressures and temperatures. Moreover, this approach will also allow to probe the chemical behavior of metallic hydrogen in mixture with other elements, which, besides its importance for planetary physics, may open up promising pathways for the synthesis of new materials.

Published
2023
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2. Aplicação de Números Aleatórios Artificiais e Método Monte Carlo na Análise de Confiabilidade de Redes Geodésicas

Author

Maria L. S. Bonimani, Vinicius Francisco Rofatto, Marcelo T. Matsuoka, and Ivandro Klein

Subjects
computational simulation, geodetic network, hypothesis testing, monte carlo method, outlier detection, quality control, Electronic computers. Computer science, QA75.5-76.95
Abstract

A Geodetic Network is a network of point interconnected by direction and/or distance measurements or by using Global Navigation Satellite System receivers. Such networks are essential for the most geodetic engineering projects, such as monitoring the position and deformation of man-made structures (bridges, dams, power plants, tunnels, ports, etc.), to monitor the crustal deformation of the Earth, to implement an urban and rural cadastre, and others. One of the most important criteria that a geodetic network must meet is reliability. In this context, the reliability concerns the network's ability to detect and identify outliers. Here, we apply the Monte Carlo Method (MMC) to investigate the reliability of a geodetic network. The key of the MMC is the random number generator. Results for simulated closed levelling network reveal that identifying an outlier is more difficult than detecting it. In general, considering the simulated network, the relationship between the outlier detection and identification depends on the level of significance of the outlier statistical test.

Published
2019
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3. Advanced high resolution x-ray diagnostic for HEDP experiments

Author

A. Y. Faenov, T. A. Pikuz, P. Mabey, B. Albertazzi, Th. Michel, G. Rigon, S. A. Pikuz, A. Buzmakov, S. Makarov, N. Ozaki, T. Matsuoka, K. Katagiri, K. Miyanishi, K. Takahashi, K. A. Tanaka, Y. Inubushi, T. Togashi, T. Yabuuchi, M. Yabashi, A. Casner, R. Kodama, and M. Koenig

Subjects
HEDP Experiments, High-energy Density Physics (HEDP), XFEL Beam, X-ray Free Electron Laser (XFEL), LiF Detector, Medicine, Science
Abstract

Abstract High resolution X-ray imaging is crucial for many high energy density physics (HEDP) experiments. Recently developed techniques to improve resolution have, however, come at the cost of a decreased field of view. In this paper, an innovative experimental detector for X-ray imaging in the context of HEDP experiments with high spatial resolution, as well as a large field of view, is presented. The platform is based on coupling an X-ray backligther source with a Lithium Fluoride detector, characterized by its large dynamic range. A spatial resolution of 2 µm over a field of view greater than 2 mm2 is reported. The platform was benchmarked with both an X-ray free electron laser (XFEL) and an X-ray source produced by a short pulse laser. First, using a non-coherent short pulse laser-produced backlighter, reduced penumbra blurring, as a result of the large size of the X-ray source, is shown. Secondly, we demonstrate phase contrast imaging with a fully coherent monochromatic XFEL beam. Modeling of the absorption and phase contrast transmission of X-ray radiation passing through various targets is presented.

Published
2018
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4. Development of new diagnostics based on LiF detector for pump-probe experiments

Author

T. Pikuz, A. Faenov, N. Ozaki, T. Matsuoka, B. Albertazzi, N.J. Hartley, K. Miyanishi, K. Katagiri, S. Matsuyama, K. Yamauchi, H. Habara, Y. Inubushi, T. Togashi, H. Yumoto, H. Ohashi, Y. Tange, T. Yabuuchi, M. Yabashi, A.N. Grum-Grzhimailo, A. Casner, I. Skobelev, S. Makarov, S. Pikuz, G. Rigon, M. Koenig, K.A. Tanaka, T. Ishikawa, and R. Kodama

Subjects
Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

We present new diagnostics for use in optical laser pump - X-ray Free Electron Laser (XFEL) probe experiments to monitor dimensions, intensity profile and focusability of the XFEL beam and to control initial quality and homogeneity of targets to be driven by optical laser pulse. By developing X-ray imaging, based on the use of an LiF crystal detector, we were able to measure the distribution of energy inside a hard X-ray beam with unprecedented high spatial resolution (∼1 μm) and across a field of view larger than some millimetres. This diagnostic can be used in situ, provides a very high dynamic range, has an extremely limited cost, and is relatively easy to be implemented in pump-probe experiments. The proposed methods were successfully applied in pump-probe experiments at the SPring-8 Angstrom Compact free electron LAser (SACLA) XFEL facility and its potential was demonstrated for current and future High Energy Density Science experiments.

Published
2018
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5. EF-1α silencing by feeding RNAi suppresses resting cyst formation in Colpoda cucullus Nag-1 strain

Author

Y Sogame, M Hori, and T Matsuoka

Subjects
EF-1α, Colpoda, encystment, feeding RNAi, Biology (General), QH301-705.5
Abstract

It is reported that the expression level of EF-1α in Colpoda cucullus Nag-1 is markedly enhanced within several hours after the onset of encystment induction. In this study, the Colpoda strain (stock EQ-1) known to promptly encyst also showed early EF-1α expression while the strain (stock ES-1) known to show prolonged encystment also showed delayed EF-1α expression. In cells in which EF-1α is silenced by feeding RNAi, the cyst formation was prolonged, but normal cyst walls were formed. These results suggest that Colpoda EF-1α is involved in the early morphogenetic events of the resting cyst formation by accelerating protein translation or cytosleletal dynamics such as microtubule disintegration.

Published
2016

6. Rivaroxaban Monotherapy in Patients With Atrial Fibrillation After Coronary Stenting

Author

Tetsuya Matoba, Satoshi Yasuda, Koichi Kaikita, Masaharu Akao, Junya Ako, Masato Nakamura, Katsumi Miyauchi, Nobuhisa Hagiwara, Kazuo Kimura, Atsushi Hirayama, Kunihiko Matsui, Hisao Ogawa, Yukihiro Koretsune, Takafumi Hiro, Tetsuya Sumiyoshi, Kazumi Kimura, Yoichiro Hashimoto, Teruyuki Hirano, Hiroyuki Daida, Yasushi Okada, Tsutomu Yamazaki, A. Nakamura, E. Tamiya, T. Yamamoto, S. Suetake, T. Noguchi, S. Nakamura, A. Matsumura, J. Kojima, S. Suwa, H. Yamaguchi, K. Kaikita, T. Yasu, A. Nakajima, T. Yamada, H. Arai, Y. Hata, T. Sakanashi, H. Tateishi, T. Nakayama, Y. Nozaki, M. Akao, Y. Okumura, M. Tokue, N. Kuroki, Y. Maruyama, T. Matoba, N. Hagiwara, H. Suzuki, Y. Nishida, M. Ajioka, K. Yumoto, S. Shimizu, T. Aoyama, H. Shimomura, T. Takeda, K. Oshiro, N. Sugishita, Y. Shibata, T. Otonari, H. Kihara, H. Ogawa, A. Ohno, M. Hazama, M. Shimizu, K. Tsukahara, S. Haruta, T. Wakeyama, T. Haruna, M. Ito, K. Fujii, N. Atsuchi, M. Sata, K. Kimura, N. Hasebe, Y. Kobayasi, K. Ohsato, K. Hironaga, Y. Naganuma, K. Anzaki, K. Oiwa, S. Okazaki, Y. Nakagawa, K. Tokuhiro, K. Tanaka, T. Momose, Y. Fukushima, R. Kametani, K. Kawamitsu, Y. Saito, S. Akashi, K. Kumagai, K. Eshima, T. Tobaru, T. Seo, K. Okuhara, K. Kozuma, Y. Ikari, T. Takahashi, I. Michishita, H. Fujikura, S. Momomura, Y. Yamamoto, K. Otomo, T. Matsubara, H. Tashiro, T. Inoue, M. Ishihara, I. Shiojima, E. Tachibana, J. Ako, K. Sumii, N. Yamamoto, N. Ohmura, T. Nakamura, Y. Morita, N. Takahashi, K. Watanabe, H. Fujinaga, M. Maruyama, T. Oka, T. Shirayama, T. Amano, K. Fukui, K. Ando, S. Oshima, S. Kagiyama, H. Teragawa, M. Yuge, S. Ono, T. Koga, K. Fujiu, M. Kuwabara, Y. Ohya, Y. Yumoto, N. Kuji, M. Ikemura, K. Kario, K. Chatani, K. Sato, H. Miyagi, M. Murakami, K. Saito, M. Hoshiga, S. Sato, N. Kubo, Y. Sakamoto, K. Ashida, H. Sakamoto, S. Murasaki, H. Uehara, T. Akasaka, Y. Ooba, S. Nakahara, Y. Hanaoka, T. Nishimiya, R. Tsunoda, Y. Onuma, S. Higuchi, A. Tani, A. Wada, M. Kato, H. Obata, Y. Higuchi, T. Endo, R. Katou, T. Matsunaga, T. Matsuoka, H. Noguchi, M. Usui, T. Hayashi, Y. Otsuji, T. Osaki, H. Zaizen, H. Yoshihara, K. Kadota, T. Hirose, T. Miyazawa, A. Mori, M. Takano, W. Shimizu, M. Wake, S. Oriso, M. Yoshiyama, S. Kakinoki, T. Nishioka, T. Ozaki, K. Nomoto, K. Seki, K. Kawai, Y. Ozaki, S. Miura, M. Kawasaki, R. Funada, K. Dote, T. Nagano, S. Okamoto, T. Kubo, Y. Murozono, T. Owada, T. Doke, T. Matsumura, M. Horiuchi, A. Takaishi, M. Yamamoto, H. Nakashima, M. Munemasa, Y. Sakata, N. Inoue, T. Ota, Y. Hamano, N. Abe, T. Tsubokura, M. Goto, I. Kubota, M. Yano, K. Umetani, T. Date, H. Morimoto, T. Noda, S. Goto, K. Hibi, A. Nakano, S. Hiramitsu, Y. Kihara, M. Sugi, N. Shiba, D. Izumi, T. Sato, S. Tayama, T. Matsui, A. Suzuki, K. Ajiki, M. Oishi, M. Kiryu, T. Ko, H. Ando, S. Miyazaki, T. Kinugawa, H. Otake, H. Kitaoka, Y. Hirata, S. Honda, M. Manita, Y. Ishii, H. Oka, Y. Nanba, M. Nishino, T. Sakamoto, T. Saito, H. Sakai, M. Ichikawa, S. Namiuchi, K. Inoue, N. Komiyama, Y. Akashi, Y. Nakamura, T. Komaru, T. Hosokawa, T. Chikamori, H. Tanaka, O. Arasaki, K. Aonuma, Y. Wakasa, T. Yoshizawa, T. Sugano, N. Yokota, A. Kakutani, T. Suzuki, Y. Abe, T. Kataoka, H. Okayama, H. Yokoi, K. Chin, K. Hasegawa, H. Tomita, H. Honzyo, H. Kawai, K. Yamamoto, Y. Morino, S. Tsujiyama, S. Hamasaki, Y. Niijima, Y. Mizuno, A. Maki, K. Tanabe, T. Murohara, S. Naomi, M. Arikawa, T. Kato, N. Matsumoto, T. Minamino, H. Sairenji, N. Miyamoto, H. Ito, Y. Matsuura, S. Hata, Y. Nakatsu, T. Onodera, M. Yoshimura, H. Amano, E. Tokutake, M. Kasao, M. Moriguchi, M. Tsuji, H. Yamamoto, Y. Yanbe, T. Iwasawa, M. Suzuki, and H. Mori

Subjects
Rivaroxaban, medicine.medical_specialty, business.industry, Unstable angina, medicine.medical_treatment, Percutaneous coronary intervention, Atrial fibrillation, medicine.disease, Thrombosis, Coronary artery disease, Internal medicine, medicine, Cardiology, cardiovascular diseases, Myocardial infarction, Cardiology and Cardiovascular Medicine, business, Stroke, medicine.drug
Abstract

Objectives The aim of this AFIRE (Atrial Fibrillation and Ischemic Events With Rivaroxaban in Patients With Stable Coronary Artery Disease) trial subgroup analysis was to examine rivaroxaban monotherapy benefits and their relation to the time between stenting and enrollment among patients after coronary stenting. Background Of 2,215 patients with atrial fibrillation and stable coronary artery disease in the AFIRE trial, rivaroxaban monotherapy was noninferior to rivaroxaban plus antiplatelet therapy (combination therapy) in terms of efficacy and superior for safety endpoints. However, thrombotic risk after antiplatelet therapy cessation remained a concern among 1,444 patients who had undergone coronary stenting >1 year before enrollment. Methods The benefits of rivaroxaban monotherapy in coronary stenting subgroups were assessed for efficacy (a composite of stroke, systemic embolism, myocardial infarction, unstable angina requiring revascularization, or death of any cause), safety (major bleeding defined according to International Society on Thrombosis and Haemostasis criteria), ischemic endpoints, net adverse clinical event, and time between stenting and enrollment. Results Efficacy and safety endpoints for monotherapy were superior to combination therapy, with HRs of 0.70 for efficacy (95% CI: 0.50-0.98; P = 0.036) and 0.55 for safety (95% CI: 0.33-0.92; P = 0.019). For ischemic endpoints, the HR was 0.82 (95% CI: 0.58-1.15; P = 0.240). The HR became smaller with longer time between stenting and enrollment (efficacy, P for interaction = 0.158; safety, P = 0.097). Conclusions In patients with atrial fibrillation after coronary stenting, the benefits of rivaroxaban monotherapy for efficacy and safety endpoints were consistent with those in the whole AFIRE trial population. The benefits became apparent with longer time between stenting and enrollment. (Atrial Fibrillation and Ischemic Events With Rivaroxaban in Patients With Stable Coronary Artery Disease Study [AFIRE]; UMIN000016612 , NCT02642419 )

Published
2021

7. Identification of cAMP-dependent phosphorylated proteins involved in the formation of environment-resistant resting cysts by the terrestrial ciliate Colpoda cucullus

Author

Y Sogame, K Kojima, T Takeshita, E Kinoshita, and T Matsuoka

Subjects
environment-resistant cyst, Colpoda, encystment, protein phosphorylation, cAMP, Biology (General), QH301-705.5
Abstract

In the terrestrial ciliate Colpoda cucullus, an elevation of the intracellular cAMP concentration was reported to be involved in environment-resistant resting cyst formation. In the present study, cAMP-dependently phosphorylated proteins of encystment-induced C. cucullus were isolated with Phos-tag agarose phosphate-affinity beads and subsequent SDS-PAGE. In a liquid chromatography/tandem mass spectrometry analysis of these phosphoproteins, 27-, 37- and 43-kDa proteins (p27, p37 and p43) were identified as Rieske iron-sulfur protein, histone H4 (hyperacetylated form), and actin, respectively.

Published
2014

8. Research and development of liquid hydrogen (LH2) temperature monitoring system for marine applications

Author

H. Shiozawa, Y. Takayama, T. Iwakiri, Y. Sugino, M. Sekiya, Kouji Yamamoto, A. Aoyagi, T. Imamura, T. Shimazaki, Z. Mikami, T. Matsuoka, K. Kinoshita, M. Sato, K. Ohtsuka, and Akihiro Nakano

Subjects
Accuracy and precision, Temperature monitoring, Materials science, Renewable Energy, Sustainability and the Environment, Nuclear engineering, Energy Engineering and Power Technology, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 01 natural sciences, Temperature measurement, 0104 chemical sciences, Pressure range, Fuel Technology, Electrical resistance and conductance, Storage tank, Resistance thermometer, 0210 nano-technology, Liquid hydrogen
Abstract

Monitoring the temperature in liquid hydrogen (LH2) storage tanks on ships is important for the safety of maritime navigation. In addition, accurate temperature measurement is also required for commercial transactions. Temperature and pressure define the density of liquid hydrogen, which is directly linked to trading interests. In this study, we developed and tested a liquid hydrogen temperature monitoring system that uses platinum resistance sensors with a nominal electrical resistance of approximately 1000 Ω at room temperature, PT-1000, for marine applications. The temperature measurements were carried out using a newly developed temperature monitoring system under different pressure conditions. The measured values are compared with a calibrated reference PT-1000 resistance thermometer. We confirm a measurement accuracy of ±50 mK in a pressure range of 0.1 MPa–0.5 MPa.

Published
2021

11. Noradrenergic uptake in the liver on 123 I‐ m IBG imaging: Influence of heart failure and diabetes

Author

Arnold F. Jacobson and Dale T. Matsuoka

Subjects
Body surface area, medicine.medical_specialty, Hepatology, medicine.diagnostic_test, business.industry, Gastroenterology, Washout, medicine.disease, Scintigraphy, Norepinephrine, Heart failure, Internal medicine, Diabetes mellitus, Cardiology, Medicine, Abnormal Liver Function Test, business, Liver function tests, medicine.drug
Abstract

BACKGROUND AND AIM Imaging noradrenergic uptake in the liver with norepinephrine analog 123 I-meta-iodobenzylguanidine (mIBG) was explored in normal controls and patients with heart failure (HF). METHODS A total of 961 HF (343 with diabetes mellitus [DM]) and 94 control subjects underwent anterior planar mIBG images including upper abdomen at 15 min (early) and 3 h 50 min (late) post-injection. Decay-corrected liver activity normalized to injected activity and body surface area (counts/pixel [cpp]/MBq/m2 ) was compared in three groups: HF with DM; HF without DM; and controls. Associations with plasma norepinephrine, liver function tests, and level of cardiac innervation were explored. RESULTS In controls, liver mIBG activity decreased over time (early: 2.78 vs late: 2.43 cpp/MBq/m2 , P 520 pg/mL) or ≥ 1 abnormal liver function test had lower early and late liver activity. In subjects with preserved cardiac mIBG uptake, HF subjects had higher and control subjects lower liver activity than comparable subjects with decreased cardiac innervation. CONCLUSIONS In HF subjects, liver mIBG activity increased over time, reversing the normal washout pattern, suggesting a compensatory change in sympathetic nerve function. DM, abnormal liver function tests, and decreased cardiac innervation were associated with decreased liver mIBG uptake in HF.

Published
2020

12. Oral Anticoagulants in the Oldest Old with Recent Stroke and Atrial Fibrillation

Author

Polymeris, A.A. Macha, K. Paciaroni, M. Wilson, D. Koga, M. Cappellari, M. Schaedelin, S. Zietz, A. Peters, N. Seiffge, D.J. Haupenthal, D. Gassmann, L. De Marchis, G.M. Wang, R. Gensicke, H. Stoll, S. Thilemann, S. Avramiotis, N.S. Bonetti, B. Tsivgoulis, G. Ambler, G. Alberti, A. Yoshimura, S. Brown, M.M. Shiozawa, M. Lip, G.Y.H. Venti, M. Acciarresi, M. Tanaka, K. Mosconi, M.G. Takagi, M. Jäger, R.H. Muir, K. Inoue, M. Schwab, S. Bonati, L.H. Lyrer, P.A. Toyoda, K. Caso, V. Werring, D.J. Kallmünzer, B. Engelter, S.T. Engelter, S.T. Lyrer, P.A. Bonati, L.H. Seiffge, D.J. Traenka, C. Polymeris, A.A. Zietz, A. Peters, N. De Marchis, G.M. Thilemann, S. Avramiotis, N.S. Gensicke, H. Hert, L. Wagner, B. Schaub, F. Meya, L. Fladt, J. Dittrich, T. Fisch, U. Macha, K. Haupenthal, D. Gassmann, L. Wang, R. Stoll, S. Schwab, S. Volbers, B. Siedler, G. Kallmünzer, B. Cappellari, M. Bonetti, B. Bovi, P. Tomelleri, G. Micheletti, N. Zivelonghi, C. Emiliani, A. Parry-Jones, A. Patterson, C. Price, C. Elmarimi, A. Parry, A. Nallasivam, A. Nor, A.M. Esis, B. Bruce, D. Bhaskaran, B. Roffe, C. Cullen, C. Holmes, C. Cohen, D. Hargroves, D. Mangion, D. Chadha, D. Vahidassr, D. Manawadu, D. Giallombardo, E. Warburton, E. Flossman, E. Gunathilagan, G. Proschel, H. Emsley, H. Anwar, I. Burger, I. Okwera, J. Putterill, J. O’Connell, J. Bamford, J. Corrigan, J. Scott, J. Birns, J. Kee, K. Saastamoinen, K. Pasco, K. Dani, K. Sekaran, L. Choy, L. Iveson, L. Mamun, M. Sajid, M. Cooper, M. Burn, M. Smith, M. Power, M. Davis, M. Smyth, N. Veltkamp, R. Sharma, P. Guyler, P. O’Mahony, P. Wilkinson, P. Datta, P. Aghoram, P. Marsh, R. Luder, R. Meenakishundaram, S. Subramonian, S. Leach, S. Ispoglou, S. Andole, S. England, T. Manoj, A. Harrington, F. Rehman, H. Sword, J. Staals, J. Mahawish, K. Harkness, K. Shaw, L. McCormich, M. Sprigg, N. Mansoor, S. Krishnamurthy, V. Giustozzi, M. Acciarresi, M. Agnelli, G. Becattini, C. Alberti, A. D’Amore, C. Cimini, L.A. Bandini, F. Tsivgoulis, G. Liantinioti, C. Chondrogianni, M. Yaghi, S. Furie, K.L. Tadi, P. Zedde, M. Abdul-Rahim, A.H. Lees, K.R. Bovi, P. Carletti, M. Rigatelli, A. Cappellari, M. Putaala, J. Tomppo, L. Tatlisumak, T. Marcheselli, S. Pezzini, A. Poli, L. Padovani, A. Vannucchi, V. Masotti, L. Sohn, S.-I. Lorenzini, G. Tassi, R. Guideri, F. Acampa, M. Martini, G. Ntaios, G. Athanasakis, G. Makaritsis, K. Karagkiozi, E. Vadikolias, K. Mumoli, N. Galati, F. Sacco, S. Tiseo, C. Corea, F. Ageno, W. Bellesini, M. Colombo, G. Silvestrelli, G. Ciccone, A. Lanari, A. Scoditti, U. Denti, L. Mancuso, M. Maccarrone, M. Ulivi, L. Orlandi, G. Giannini, N. Tassinari, T. De Lodovici, M.L. Rueckert, C. Baldi, A. Toni, D. Letteri, F. Pieroni, A. Giuntini, M. Lotti, E.M. Flomin, Y. Kargiotis, O. Karapanayiotides, T. Monaco, S. Baronello, M.M. Csiba, L. Szabó, L. Chiti, A. Giorli, E. Del Sette, M. Imberti, D. Zabzuni, D. Doronin, B. Volodina, V. Michel, P. Vanacker, P. Barlinn, K. Pallesen, L.-P. Barlinn, J. Deleu, D. Melikyan, G. Ibrahim, F. Akhtar, N. Gourbali, V. Todo, K. Kimura, K. Shibazaki, K. Yagita, Y. Furui, E. Itabashi, R. Terasaki, T. Shiokawa, Y. Hirano, T. Suzuki, R. Kamiyama, K. Nakagawara, J. Takizawa, S. Homma, K. Okuda, S. Okada, Y. Maeda, K. Kameda, T. Kario, K. Nagakane, Y. Hasegawa, Y. Akiyama, H. Shibuya, S. Mochizuki, H. Ito, Y. Nakashima, T. Matsuoka, H. Takamatsu, K. Nishiyama, K. Tanaka, K. Endo, K. Miyagi, T. Osaki, M. Kobayashi, J. Okata, T. Tanaka, E. Sakamoto, Y. Tokunaga, K. Takizawa, H. Takasugi, J. Matsubara, S. Higashida, K. Matsuki, T. Kinoshita, N. Shiozawa, M. Ide, T. Yoshimoto, T. Ando, D. Fujita, K. Kumamoto, M. Kamimura, T. Kikuno, M. Mizoguchi, T. Sato, T. NOACISP-LONGTERM, Erlangen Registry, CROMIS-2, RAF, RAF-DOAC, SAMURAI-NVAF Verona Registry Collaborators

Abstract

Objective: To investigate the safety and effectiveness of direct oral anticoagulants (DOAC) versus vitamin K antagonists (VKA) after recent stroke in patients with atrial fibrillation (AF) aged ≥85 years. Methods: Individual patient data analysis from seven prospective stroke cohorts. We compared DOAC versus VKA treatment among patients with AF and recent stroke (

Published
2022

15. Stimulated Raman backscattering from a laser wakefield accelerator

Author

A E Hussein, J Ludwig, K Behm, Y Horovitz, P-E Masson-Laborde, V Chvykov, A Maksimchuk, T Matsuoka, C McGuffey, V Yanovsky, W Rozmus, and K Krushelnick

Subjects
laser wakefield acceleration, stimulated Raman scattering, relativistic laser–plasma interactions, electron beams, plasma physics, accelerators, Science, Physics, QC1-999
Abstract

Experiments were performed using the HERCULES laser system at the University of Michigan to study backward stimulated Raman scattering (BSRS) from a laser wakefield accelerator driven with a 30 fs pulse. 'The spectrum of backscattered light was found to be significantly broadened and red-shifted in cases where electrons were accelerated. BSRS broadening (red-shifting) was found to increase with respect to both plasma density and accelerated electron charge for laser powers exceeding 100 TW. Two-dimensional Particle-in-Cell simulations reveal temporal dynamics for the BSRS emission, which ceases as the wakefield bubble is evacuated of plasma electrons because of relativistic self-focusing. The intensity and duration of the BSRS signal was found to vary with plasma density and laser intensity. Both experimental and simulation results indicate that backward SRS is associated with plasma electron density within the wakefield bubble. This measurement can serve as a diagnostic of bubble dynamics, and is correlated with trapped electron charge in this regime.

Published
2018
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16. Cyst wall formation in the ciliated protozoan Colpoda cucullus: cyst wall is not originated from pellicle membranes

Author

A Kida and T Matsuoka

Subjects
Colpoda, encystment, cyst wall, ectocyst, endocyst, Biology (General), QH301-705.5
Abstract

Ultrastructural changes during encystment (resting cyst formation) of Colpoda cucullus were observed with special reference to cyst wall formation. Within 1.5 h after encystment induction, fragmentation of some of the mitochondria occurred, followed by the appearance of a number of net-like globules in the cytoplasm, which were expelled to outside and then involved in cell-to-cell or cell-to-substratum adhesion. The cells were transformed into a spherical shape, and a number of ellipsoidal vacuoles in which ectocyst precursor (amorphous substance) was contained appeared near the cell surface (some of these opened to the outside). In this stage, the ectocyst (outermost layer) was completed. In 3 ~ 10 h toluidine blue-stained substance (TBS), which was probably the precursor for the first synthesized layer of endocyst (en-1), was released from a point near the cell surface and diffused over the cell surface (diffused into between the ectocyst and plasma membrane). Thereby, the ectocyst was lined by the en-1. Thereafter, several layers of endocyst were periodically formed for 1 ~ 2 weeks. Finally a number of reserve grains were accumulated, and cilia were resorbed.

Published
2006

17. Determination of TEC using GPS data from dual frequency receivers for the production of ionospheric maps to Brazil

Author

Paulo de O. Camargo and Marcelo T. Matsuoka

Subjects
GPS, ionosphere, TEC map., Geography. Anthropology. Recreation, Cartography, GA101-1776
Abstract

Nowadays, one of the main drawbacks of the GPS accuracy for L1 users is the delay due to ionosphere. The error associated to the ionosphere depends on the Total Electron Content (TEC) in the ionospheric layer, that is influenced by several variables, including the solar cycle, the season, the local time, the geographical location of the receiver and the Earth’s magnetic field. The monitoring of the variation of TEC is important because it is the principal parameter that describes the ionospheric activity. Due to the characteristic dispersive of the ionosphere, the TEC has been computed using GPS data from double frequency receiver. In Europe and in North America, several research centers produce regional and global scale maps of the VTEC (Vertical TEC) using GPS data. In Brazil it can be used the GPS data from RBMC (Brazilian Network for Continuous Monitoring) for studying the behavior of TEC in the Brazilian area. The purpose of this paper is to produce maps of TEC of the ionosphere for Brazilian area using GPS data from double frequency receivers. The methodology and the strategy adopted for obtaining of the proposed results are also presented.

Published
2004

18. From Bench to Pilot Plant

Author

Mehdi Nafissi, Nikolaos H . Petousis, Edward J. J. Grabowski, Matthew J. Sharp, Mark W. Andersen, Evan G. Boswell, Bobby N. Glover, Michael T. Martin, Richard T. Matsuoka, Xiaoming Zhou, David M. Barnes, Jianguo Ji, Ji Zhang, Steven A. King, Steven J. Wittenberger, Howard E. Morton, Roger N. Brummel

Published
2002

21. Valor preditivo do 'Clinical Risk Index for Babies' para o risco de mortalidade neonatal Predictive value of the 'Clinical Risk Index for Babies' for the risk of neonatal death

Author

Oscar T. Matsuoka, Lilian S.R. Sadeck, Jesselina F.S. Haber, Renata S.M. Proença, Marta M.G. Mataloun, José L.A. Ramos, and Cléa R. Leone

Subjects
Mortalidade neonatal, Peso ao nascer, Idade gestacional, Unidades de terapia intensiva neonatal, Neonatal mortality, Birth weight, Gestacional age, Intensive care units, Public aspects of medicine, RA1-1270
Abstract

OBJETIVO: Comparar o valor preditivo do CRIB (Clinical Risk Index for Babies) para o risco de mortalidade neonatal ao peso de nascimento (PN) e idade gestacional (IG). MÉTODO: Numa coorte prospectiva foram estudados, durante o ano de 1996, 71 recém-nascidos admitidos na unidade de terapia intensiva, com PN < 1.500 g e/ou IG < 31 semanas. RESULTADOS: A taxa de mortalidade foi de 29,6%; para PN < 1.000 g ou IG < 29 semanas foi de 60%, enquanto que para o escore de CRIB > 10 foi de 100%. CONCLUSÕES: O escore de CRIB > 10 correspondeu a maiores especificidade e valor preditivo positivo em relação aos demais parâmetros. A área determinada pela "receiver operating characteristic" relativa ao CRIB também foi superior. O CRIB mostrou-se um marcador mais acurado na previsão de risco de mortalidade quando comparado ao PN ou IG isoladamente.OBJECTIVE: Several indicators, mainly birthweight and gestational age, have been used to predict the mortality risk in neonatal intensive care units. In order to assess the potential value of CRIB in predicting neonatal mortality, the score was used over the first 12 hours of life of the newborns admitted to this unit, during the year of 1996. METHOD: The inclusion criteria consisted of all infants without inevitably lethal congenital malformations, birthweight below 1,500g and/or gestational age less than 31 weeks. Newborn children who died within 12 hours after delivery were excluded. The CRIB score covers birth weight, gestational age, the presence of congenital malformations (not inevitably lethal ) and three indexes of physiological status during first 12 hours after birth - maximum and minimum appropriate fraction of inspired oxygen and maximum (most acidotic) base excess. RESULTS: In a prospective cohort, seventy one newborn children were studied. The birthweight (average) was 1,119 ± 275.6 g, gestational age 30 weeks 4/7 ±2 weeks 3/7; male (57%); Apgar 1° min. score

Published
1998
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22. Pressure-induced superconductivity in lightly doped RFeAsO1-xFx (R=Sm and Nd)

Author

K. Miyoshi, A. Shiota, T. Matsuoka, K. Otsuka, S. Nishigori, and H. Kitagawa

Subjects
History, Computer Science Applications, Education
Abstract

We performed the measurements of electrical resistivity (ρ) and dc magnetization (M) as a function of temperature (T) under pressure to investigate whether or not the superconductivity is induced by the application of pressure in lightly doped RFeAsO1-xFx (R=Sm and Nd) using pulse current sintered (PCS) high density polycrystalline specimens. We have successfully observed pressure induced superconductivity with T c of ∼6 K (∼8 K) above ∼4 GPa (∼1 GPa) for R=Sm (R=Nd). An anomaly corresponding to a magnetic phase transition into spin density wave (SDW) state was observed in the ρ(T) curves in the entire pressure range, indicating that the superconducting and SDW states coexist in the T-P phase diagram. Volume fraction of the superconductivity is found to be very small. This is consistent with the coexistence of the superconducting and SDW phases.

Published
2022

24. Increased oxygen uptake and utilization in the peripheral muscles, rather than cardiac function reserve, may be determinants of increased peak VO2 by cardiac rehabilitation in heart failure

Author

T Kono, A Soyama, S Murakami, T Matsuoka, H Hasegawa, Masaaki Hoshiga, and Kazushi Sakane

Subjects
Cardiac function curve, medicine.medical_specialty, Rehabilitation, business.industry, medicine.medical_treatment, medicine.disease, Oxygen uptake, Peripheral, Heart failure, Internal medicine, medicine, Cardiology, Cardiology and Cardiovascular Medicine, Peak vo2, business
Abstract

Background Peak oxygen consumption (peak VO2) is a major prognostic parameter in heart failure (HF). Previous studies have shown a relationship between peak VO2 and impaired oxygen uptake and utilization in the peripheral muscles. The purpose of this study was to clarify the determinant of increased peak VO2 by cardiac rehabilitation (CR) in patients with HF. Methods We performed echocardiography during upright ramp bicycle cardiopulmonary exercise test in 30 HF patients (61±1 years of age, 80% male) before and 6 months after CR. HR reserve was determined as the change in HR from rest to peak exercise, expressed as a percentage of the predicted maximal HR reserve. Elastance index (EAI) and LV end-systolic elastance index (ELVI) were derived as the ratio of end-systolic pressure to stroke volume index and end-systolic volume index, respectively. End-systolic pressure was estimated from the equation 0.9 × brachial systolic blood pressure. Ventriculo-arterial coupling (VAC) was calculated as the quotient of EAI and ELVI. The ratio of LDEDVI to E/e' mean was used to evaluate LV diastolic compliance. Systemic vascular resistance index was calculated as mean arterial pressure divided by echocardiography calculated cardiac index and multiplied by 80. The arterial venous oxygen content difference (C (A-V) O2 gradient) was calculated by using the Fick equation as: VO2/echocardiography calculated cardiac output. Results Peak VO2 and C (A-V) O2 gradient were increased by CR. However, heart rate reserve, systolic reserve, VAC, diastolic reserve and vasodilation reserve were unchanged by CR (Table 1). Conclusions Increased oxygen uptake and utilization in the peripheral muscles, rather than cardiac function reserve, may be determinants of increased peak VO2 by CR in HF. Table 1 Funding Acknowledgement Type of funding source: None

Published
2020

25. Experimental study of temperature sensor for an ocean-going liquid hydrogen (LH2) carrier

Author

T. Matsuoka, H. Shiozawa, Akihiro Nakano, Kouji Yamamoto, Y. Takayama, K. Ohtsuka, T. Iwakiri, T. Shimazaki, K. Kinoshita, Z. Mikami, A. Aoyagi, M. Sekiya, and M. Sato

Subjects
Accuracy and precision, Materials science, Test facility, Nuclear engineering, 05 social sciences, General Physics and Astronomy, chemistry.chemical_element, 02 engineering and technology, 021001 nanoscience & nanotechnology, Metrology, chemistry, Thermometer, 0502 economics and business, General Materials Science, Resistance thermometer, 050207 economics, 0210 nano-technology, Platinum, Liquid hydrogen
Abstract

The prototype temperature sensors for an ocean-going liquid hydrogen (LH2) carrier were manufactured by way of trial. All of the sensors adopted Platinum 1000 (PT-1000) resistance thermometer elements. Various configurations of preproduction temperature sensors were tested in AIST’s LH2 test facility. In the experiments, a PT-1000 resistance thermometer, calibrated at the National Metrology Institute of Japan at AIST, was used as the standard thermometer. The temperatures measured by the preproduction sensors were compared with the temperatures measured by the standard thermometer, and the measurement accuracy of the temperature sensors in LH2 was investigated and discussed. It was confirmed that the measurement accuracies of the preproduction temperature sensors were within ±50 mK, which is the required measurement accuracy for a technical demonstration ocean-going LH2 carrier.

Published
2018

27. Prevalence of, and risk factors for, carriage of carbapenem-resistant Enterobacteriaceae among hospitalized patients in Japan

Author

Norihisa Yamamoto, Isao Nishi, K. Matsunami, Ryuji Kawahara, Kouji Yamamoto, Satomi Yukawa, Yukihiro Akeda, T. Matsuoka, Hideharu Hagiya, H. Ohnishi, Y. Takayama, Hiroyuki Yoshida, Rumiko Asada, Kazunori Tomono, T. Taniguchi, Shigeyuki Hamada, T. Kase, and Rathina Kumar Shanmugakani

Subjects
Male, 0301 basic medicine, Microbiology (medical), medicine.medical_specialty, Pediatrics, Hospitalized patients, 030106 microbiology, Carbapenem-resistant enterobacteriaceae, Logistic regression, Enteral administration, Feces, 03 medical and health sciences, 0302 clinical medicine, Japan, Risk Factors, Internal medicine, Acute care, Prevalence, Humans, Medicine, 030212 general & internal medicine, Feeding tube, Aged, Aged, 80 and over, Bacteriological Techniques, Inpatients, business.industry, Enterobacteriaceae Infections, General Medicine, Hospitals, Culture Media, Carbapenem-Resistant Enterobacteriaceae, Cross-Sectional Studies, Infectious Diseases, Carriage, Carrier State, Female, business, Asymptomatic carrier
Abstract

The prevalence of carbapenem-resistant Enterobacteriaceae (CRE) has been reported to be lower in Japan than in many other countries. However, extensive surveillance for CRE carriage has not been performed in Japan.To investigate the prevalence of CRE carriage in Japan among convalescent patients considered to be at high risk of being CRE carriers using an improved selective culture medium.A cross-sectional survey was conducted in 22 acute care hospitals (ACHs) and 21 long-term care hospitals (LTCHs) in northern Osaka from December 2015 to January 2016. Patients who used incontinence aids, an enteral feeding tube or a urinary catheter were enrolled. Faecal specimens were examined using the newly developed M-ECC for imipenemase (IMP)-producing CRE, which is the most prevalent form of CRE in Japan. The positive isolates were analysed by polymerase chain reaction and sequencing. Risk factors associated with carriage were analysed by logistic regression.Among 1507 patients, 184 (12.2%) carried CRE. The percentage of positive patients was significantly higher in LTCHs (14.9%) than in ACHs (3.6%) (P0.001). Risk factors for CRE carriage were longer hospital stay [odds ratio (OR) 2.59; 95% confidence interval (CI) 1.87-3.60], enteral feeding (OR 3.03, 95% CI 2.08-4.42) and antibiotic exposure (OR 2.00, 95% CI 1.40-2.87). Among the 233 CRE isolates identified, 223 were IMP producers; the remaining isolates did not produce carbapenemase.This is the first Japanese report to demonstrate the significant spread of CRE in both ACHs and LTCHs using an improved selective medium. A coordinated regional approach may help to prevent further spread.

Published
2017

28. Effectiveness of early administration of tranexamic acid in patients with severe trauma

Author

A Shiraishi, S Kushimoto, Y Otomo, H Matsui, A Hagiwara, K Murata, M Hayakawa, K Maekawa, D Saitoh, H Ogura, J Sasaki, T Shibusawa, T Uejima, A Yaguchi, M Takeda, H Ishikura, Y Nakamura, D Kudo, N Kaneko, T Matsuoka, Y Hagiwara, N Morimura, S Furugori, H Kato, T Kanemura, G Mayama, S Kim, O Takasu, and K Nishiyama

Subjects
Adult, Male, Blood transfusion, medicine.medical_treatment, Hemorrhage, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Blood Transfusion, In patient, 030212 general & internal medicine, Propensity Score, Aged, Retrospective Studies, business.industry, 030208 emergency & critical care medicine, Retrospective cohort study, Middle Aged, Antifibrinolytic Agents, Treatment Outcome, Tranexamic Acid, Severe trauma, Brain Injuries, Anesthesia, Propensity score matching, Injury Severity Score, Female, Surgery, Observational study, business, Tranexamic acid, medicine.drug
Abstract

Background A reduction in mortality with the early use of tranexamic acid has been demonstrated in severely injured patients who are bleeding. However, the modest treatment effect with no reduction in blood transfusion has raised concerns. The aim of the present study was to estimate the effectiveness of regular use of tranexamic acid in severely injured patients. Methods This multicentre observational study used retrospectively collected data from consecutive injured patients (Injury Severity Score at least 16) treated in 15 Japanese academic institutions in 2012. A propensity score-matched analysis compared patients who did or did not receive tranexamic acid administration within 3 h of injury. Study outcomes included 28-day all-cause and cause-specific mortality, and need for blood transfusion. Results Of 796 eligible subjects, 281 were treated with tranexamic acid. Propensity score matching selected a total of 500 matched subjects (250 in each group). Tranexamic acid administration was associated with lower 28-day mortality (10·0 versus 18·4 per cent; difference −8·4 (95 per cent c.i. –14·5 to −2·3) per cent) and lower 28-day mortality from primary brain injury (6·0 versus 13·2 per cent; difference −7·2 (−12·3 to −2·1) per cent). However, there was no significant difference between groups in the need for blood transfusion (33·2 versus 34·8 per cent; difference −1·6 (−9·9 to 6·7) per cent). Conclusion Early tranexamic acid use was associated with reduced mortality in severely injured patients, in particular those with a primary brain injury.

Published
2017

30. Development of Large-Scale Routes to Potent GPR119 Receptor Agonists

Author

Matthew Jude Sharp, Will L. Canoy, Kae M. Bullock, Eric Eugene Boros, Xiao-ming M. Zhou, Richard T. Matsuoka, Greg A. Erickson, Vassil I. Elitzin, Mark B. Mitchell, Matthew C. Salmon, David H. Igo, Nicole M. Deschamps, Daniel W. Reynolds, Andrew D. Brown, Gregory E. Peckham, Istvan Kaldor, Jennifer F. Toczko, Shannon Condon, Carpenter Andrew J, Elie Amine Tabet, Jing M. Fang, Biren K. Joshi, Lianming Michael Wu, and Jeremy D. Cobb

Subjects
0301 basic medicine, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, GPR119, Chemistry, 030220 oncology & carcinogenesis, Organic Chemistry, Physical and Theoretical Chemistry, Receptor, Combinatorial chemistry
Abstract

Practical and scalable syntheses were developed that were used to prepare multikilogram batches of GSK1292263A (1) and GSK2041706A (15), two potent G protein-coupled receptor 119 (GPR119) agonists. Both syntheses employed relatively cheap and readily available starting materials, and both took advantage of an SNAr synthetic strategy.

Published
2016

32. Retroperitoneal leiomyosarcoma: a case report

Author

T, Matsuoka, H, Tsujioka, S, Matsuoka, S, Sorano, A, Toyama, H, Mori, H, Yamamoto, S, Nakamura, T, Fukami, M, Goto, R, Matsuoka, and F, Eguchi

Subjects
Leiomyosarcoma, Ovarian Neoplasms, Humans, Female, Retroperitoneal Neoplasms, Aged
Abstract

Retroperitoneal leiomyosarcoma is a relatively rare and aggressive tumor. Because of its rarity, it is difficult to arrive at a definite diagnosis preoperatively and to design an effective strategy. Here the authors report a case of peritoneal leiomyosarcoma in which diagnosis was difficult because the clinical course resembled that of ovarian cancer. A 77-year-old woman diagnosed with ovarian cancer underwent laparotomy. The excised tumor contained a necrotic polypoid mass that histologically displayed the features of leiomyosarcoma. The patient received adjuvant chemotherapy with a combination of gemcitabine and docetaxel but died two months after surgery owing to the aggressive behavior of the tumor. Because the preoperative diagnosis in this case was ovarian cancer, arriving at a treatment strategy assuming peritoneal leiomyosarcoma was difficult. If complete surgical resection of tumor is not performed, as in the present case, the prognosis can be extremely poor.

Published
2018

33. A comparative analysis of micafungin and caspofungin for empirical antifungal therapy in antibiotic-unresponsive febrile patients with hematologic malignancies

Author

T, Seko, E, Usami, M, Kimura, T, Nakao, T, Matsuoka, T, Yoshimura, N, Kanamori, T, Tachi, and H, Teramachi

Subjects
Adult, Aged, 80 and over, Male, Methicillin-Resistant Staphylococcus aureus, Antifungal Agents, Fever, Middle Aged, Staphylococcal Infections, Echinocandins, Lipopeptides, Young Adult, Mycoses, Caspofungin, Drug Resistance, Fungal, Risk Factors, Hematologic Neoplasms, Micafungin, Humans, Female, Aged, Retrospective Studies
Abstract

This study was retrospectively carried out to compare the efficacy of echinocandins such as micafungin (MCFG) and caspofungin (CPFG) in the treatment of antibiotic-unresponsive febrile patients with hematologic malignancies. A total of 163 patients received either MCFG or CPFG. We evaluated the efficacy of echinocandin against fever decline in all patients. Fever decline, defined as a body temperature of less than 37.5 °C sustained for more than 48 h without scheduled antipyretic medication. Efficacy assessments showed that the incidence of fever decline was not significantly different between the MCFG and CPFG groups (P=0.599). The median number of days from the start of echinocandin administration to fever decline was 5 in both the MCFG and CPFG groups. Multivariate analysis showed that the use of anti-MRSA drugs (HR, 0.64; 95%CI, 0.45-0.90; P=0.011) and a change from echinocandins to voriconazole or liposomal-amphotericin B (HR, 0.50; 95%CI, 0.30-0.74; P0.001) are significant risk factors for sustained fever. A significant difference (P=0.002) in incidence of fever decline was however associated with differences in the timing of anti-MRSA drug administration. The median number of days from the start of echinocandin administration to fever decline was 5 when administration of the anti-MRSA drug occurred "simultaneously or prior to echinocandin start" and 11 in the "next day or later of echinocandin start" group. In other words, starting anti-MRSA drug treatment after echinocandin treatment is a risk factor. In conclusion, MCFG and CPFG have similar efficacy as empirical antifungal agents in the treatment of antibioticunresponsive febrile patients with hematopoietic malignancies.

Published
2018

34. Evaluation of antimicrobial stewardship (AS) for appropriate use of antimicrobial agents

Author

T, Matsuoka, M, Kato, Y, Shinoda, K, Ohashi, S, Yoshida, T, Mori, T, Tachi, T, Yoshimura, and H, Teramachi

Subjects
Methicillin-Resistant Staphylococcus aureus, Piperacillin, Penicillanic Acid, Microbial Sensitivity Tests, Length of Stay, Staphylococcal Infections, Pharmacists, Anti-Bacterial Agents, Hospitalization, Antimicrobial Stewardship, Piperacillin, Tazobactam Drug Combination, Carbapenems, Pharmaceutical Services, Humans, Hospital Mortality
Abstract

We implemented an antimicrobial stewardship (AS) program whereby pharmacists sought appropriate use of antimicrobial agents in January 2012. At that time, we targeted anti-methicillin-resistant Staphylococcus aureus (MRSA) agents and carbapenems; however, in January 2014, we added tazobactam/piperacillin (TAZ/PIPC). We evaluated outcomes using multilateral analyses. The average one-day dosage of carbapenems increased; however, the duration of administration and number of recipient patients decreased significantly (P0.01). Moreover, the percentage of patients receiving meropenem (MEPM), for whom the time above minimal inhibitory concentration (MIC) was 40% or higher increased (P0.01). In contrast, patient utilization of TAZ/PIPC increased significantly after targeting of carbapenems as specific antibacterial agents. However, after TAZ/PIPC was targeted as a specific antibacterial agent, the number of TAZ/PIPC administrations decreased significantly (P0.01). The duration of hospitalization and mortality rate in patients receiving specific antibacterial agents significantly decreased after implementation of the AS program (P0.01). In conclusion, pharmacist's interventions to provide AS and patient follow-up reduced improper use and promoted proper administration of antibacterial agents. Furthermore, AS was effective in improving patient prognoses and suppressing drug-resistant strains, as well as promoting effective treatment.

Published
2018

35. P2.18-15 Surgical Outcomes of Pneumonectomy After Induction Therapy for Non-Small-Cell Lung Cancer

Author

T. Yokoyama, Y. Otsuki, Hidenao Kayawake, S. Itasaka, T. Nakashima, Norihito Okumura, Y. Yamamoto, A. Takahashi, and T. Matsuoka

Subjects
Pulmonary and Respiratory Medicine, Oncology, medicine.medical_specialty, business.industry, medicine.medical_treatment, medicine.disease, Pneumonectomy, Internal medicine, Induction therapy, medicine, Non small cell, Lung cancer, business
Published
2019

36. Cartilage regeneration by autologous adipose-derived mesenchymal stem cells for the treatment of osteoarthritis

Author

Y. Jiang, K. Shirakawa, C. Yang, T. Matsuoka, and S. Iwata

Subjects
Cancer Research, Transplantation, medicine.medical_specialty, WOMAC, business.industry, Cartilage, Regeneration (biology), medicine.medical_treatment, Immunology, Mesenchymal stem cell, Arthritis, Knee replacement, Cell Biology, Osteoarthritis, medicine.disease, Surgery, Cell therapy, medicine.anatomical_structure, Oncology, medicine, Immunology and Allergy, business, Genetics (clinical)
Abstract

Background & Aim Osteoarthritis (OA) is a degenerative joint disease mainly caused by wear and tear of the cartilage cushion between joints. Millions of people, especially the aged population, are suffering chronic pain and limited movement due to osteoarthritis around the world. Current treatment of osteoarthritis generally focuses on medication and knee replacement surgery depending on the deterioration level of the knee joint. However, medication has a limited effect on the symptoms and the patients who take the knee replacement surgery may suffer persistent pain around the replaced joint. In view of these limitations, numerous efforts have been made to find a more effective treatment, such as cell therapy to prevent the cartilage from deteriorating and reverse the course of arthritis. Methods, Results & Conclusion Here we show that in twelve clinical cases, the cartilage was observed successfully regenerating and covering the defect region in knees after the intra-articular injection with adipose-derived mesenchymal stem cells (MSCs), and the treatment highly improves the symptoms of osteoarthritis. Basically, the adipose-derived MSCs from the patients are cultured and expanded to a specific amount with the optimized stem cell culture medium, the HELENE MEDIUM. After that, the cultured MSCs are directly injected into the injured knee joints of patients. The cartilage has gradually regenerated and been monitored by MRI photography in six months after treatment. Moreover, these patients showed improvement in clinical outcomes by measurements of the WOMAC Osteoarthritis index and Harris Hip Score. Based on the preclinical and clinical reports, except for replacement as chondrocytes, MSCs are able to secrete paracrine factors which take effects in modulating the microenvironment of the damaged sites, leading to an optimal condition for tissue regeneration. Also, further research will focus on determining co-injection of MSCs with differential factors could facilitate the cartilage regeneration. In summary, our results demonstrate the success in MSCs treatment of osteoarthritis by cartilage regeneration in clinical cases. We expect our findings of MSCs for osteoarthritis treatment could be a starting point in the field of regenerative therapy to more cartilage diseases and unsolved diseases.

Published
2019

40. SURGICALLY TREATED CASES OF CHILDREN WITH CONGENITAL CYSTIC LUNG DISEASE: THE SIGNIFICANCE OF VIDEO-ASSISTED THORACIC SURGERY IN CHILDREN AND OPERATIVE TIMING

Author

T. Nakashima, T. Matsuoka, Norihito Okumura, and A. Takahashi

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, business.industry, Video assisted thoracic surgery, medicine, Cardiology and Cardiovascular Medicine, Critical Care and Intensive Care Medicine, Congenital cystic lung disease, business, Surgery
Published
2019

41. Risk factors for neutropenia with lenalidomide plus dexamethasone therapy for multiple myeloma

Author

Y, Mitani, E, Usami, M, Kimura, T, Nakao, K, Okada, T, Matsuoka, T, Kokuryou, T, Yoshimura, and M, Yamakawa

Subjects
Aged, 80 and over, Male, Neutropenia, Antineoplastic Agents, Hormonal, Antineoplastic Agents, Middle Aged, Dexamethasone, Thalidomide, Hemoglobins, Risk Factors, Antineoplastic Combined Chemotherapy Protocols, Humans, Female, Multiple Myeloma, Lenalidomide, Aged
Abstract

Neutropenia may develop as an adverse event in patients with multiple myeloma receiving lenalidomide (LEN) plus dexamethasone (DEX) therapy. In the present study, we examined the risk factors associated with grade 3/4 neutropenia during the first cycle of LEN plus DEX therapy. We observed that hemoglobin level (≤ 8.5 g/dl) was a significant risk factor for grade 3/4 neutropenia during the first cycle of therapy (odds ratio: 19.40; 95% confidence interval: 2.68-141.00; p0.01). thus, our findings suggest that determining the hemoglobin level could be useful in the risk management for neutropenia in patients receiving LEN plus DEX therapy.

Published
2016

42. Antibacterial therapy of aspiration pneumonia in patients with methicillin-resistant Staphylococcus aureus-positive sputum: identification of risk factors

Author

Y, Shinoda, T, Matsuoka, T, Mori, S, Yoshida, K, Ohashi, T, Yoshimura, and T, Sugiyama

Subjects
Methicillin-Resistant Staphylococcus aureus, Risk Factors, Sputum, Humans, Hospital Mortality, Quinolones, Staphylococcal Infections, Pneumonia, Aspiration, Anti-Bacterial Agents
Abstract

Inappropriate antimicrobial treatment could adversely affect the recovery of patients with aspiration pneumonia. We attempted to identify inappropriate antibacterial treatment and to determine the standard use of anti-methicillin-resistant Staphylococcus aureus (MRSA) drugs in aspiration pneumonia patients with MRSA-positive in sputum. Aspiration pneumonia patients with MRSA-positive sputum treated between January 2013 and May 2013 were included in this study to determine the risk factors for death during hospitalization. The relationship between anti-MRSA medicine use and death during hospitalization was also investigated. More than 10⁷ MRSA colony-forming units in sputum culture, creatinine clearance of less than 30 mL/min, and quinolone use were found to be risk factors for death during hospitalization. The death rate during hospitalization was significantly lower in cases a Geckler classification of 4 or 5 when anti-MRSA treatment was initiated soon after the culture was obtained. Therefore, we concluded that the use of quinolones as antibacterial treatment in aspiration pneumonia patients with MRSA-positive sputum should be avoided and that anti-MRSA treatment should be started in cases with good quality sputum cultures.

Published
2016

43. Novel product ions of 2-aminoanilide and benzimidazole Ag(I) complexes using electrospray ionization with multi-stage tandem mass spectrometry

Author

Richard T. Matsuoka, Svetlana A. Burova, Russ N. Fitzgerald, David J. Burinsky, Byron S. Johnson, and Roman Davis

Subjects
Hydride, Chemistry, Electrospray ionization, Organic Chemistry, Analytical chemistry, Tandem mass spectrometry, Orbitrap, Mass spectrometry, Analytical Chemistry, Ion, law.invention, Homologous series, chemistry.chemical_compound, law, Physical chemistry, Quadrupole ion trap, Spectroscopy
Abstract

RATIONALE The 2-aminoaniline scaffold is of significant value to the pharmaceutical industry and is embedded in a number of pharmacophores including 2-aminoanilides and benzimidazoles. A novel application of coordination ion spray mass spectrometry (CIS-MS) for interrogating the silver ion (Ag+) complexes of a homologous series of these compounds using multi-stage tandem mass spectrometry is described. Unlike the ubiquitous alkali metal ion complexes, Ag+ complexes of 2-aminoanilides and benzimidazoles were found to yield [M – H]+ ions in significant abundance via gas-phase elimination of the metal hydride (AgH) resulting in unique product ion cascades. METHODS Sample introduction was by liquid chromatography with mass spectrometry analysis performed on a hybrid linear ion trap/orbitrap instrument capable of high-resolution measurements. RESULTS Rigorous structural characterization by multi-stage tandem mass spectrometry using [M + H]+, [M – H]– and [M – H]+ precursor ions derived from ESI and CIS experiments was performed for the homologous series of 2-aminoanilide and benzimidazole compounds. A full tabular comparison of structural information resulting from these product ion cascades was produced. CONCLUSIONS Multi-stage tandem mass spectrometry of [M – H]+ ions resulting from Ag+ complexes of 2-aminoanilides and benzimidazoles in CIS-MS experiments produced unique product ion cascades that exhibited complementary structural information to that obtained from tandem mass spectrometry of [M + H]+ and [M – H]– ions by electrospray ionization (ESI). These observations may be broadly applicable to other compounds that are observed to form Ag+ complexes and eliminate AgH. Copyright © 2012 John Wiley & Sons, Ltd.

Published
2012

44. Abstracts

Author

V. Dunet, A. Dabiri, G. Allenbach, A. Goyeneche Achigar, B. Waeber, F. Feihl, R. Heinzer, J. O. Prior, J. E. Van Velzen, J. D. Schuijf, F. R. De Graaf, M. A. De Graaf, M. J. Schalij, L. J. Kroft, A. De Roos, J. W. Jukema, E. E. Van Der Wall, J. J. Bax, E. Lankinen, A. Saraste, T. Noponen, R. Klen, M. Teras, T. Kokki, S. Kajander, M. Pietila, H. Ukkonen, J. Knuuti, A. P. Pazhenkottil, R. N. Nkoulou, J. R. Ghadri, B. A. Herzog, R. R. Buechel, S. M. Kuest, M. Wolfrum, O. Gaemperli, L. Husmann, P. A. Kaufmann, D. Andreini, G. Pontone, S. Mushtaq, L. Antonioli, E. Bertella, A. Formenti, S. Cortinovis, G. Ballerini, C. Fiorentini, M. Pepi, A. S. Koh, J. S. Flores, F. Y. J. Keng, R. S. Tan, T. S. J. Chua, A. D. Annoni, G. Tamborini, M. Fusari, A. L. Bartorelli, S. H. Ewe, A. C. T. Ng, V. Delgado, J. Schuijf, F. Van Der Kley, A. Colli, A. De Weger, N. A. Marsan, K. H. Yiu, A. C. Ng, S. A. J. Timmer, P. Knaapen, T. Germans, P. A. Dijkmans, M. Lubberink, J. M. Ten Berg, F. J. Ten Cate, I. K. Russel, A. A. Lammertsma, A. C. Van Rossum, Y. Y. Wong, G. Ruiter, P. Raijmakers, W. J. Van Der Laarse, N. Westerhof, A. Vonk-Noordegraaf, G. Youssef, E. Leung, G. Wisenberg, C. Marriot, K. Williams, J. Etele, R. A. Dekemp, J. Dasilva, D. Birnie, R. S. B. Beanlands, R. C. Thompson, A. H. Allam, L. S. Wann, A. H. Nureldin, G. Adelmaksoub, I. Badr, M. L. Sutherland, J. D. Sutherland, M. I. Miyamoto, G. S. Thomas, H. J. Harms, S. De Haan, M. C. Huisman, R. C. Schuit, A. D. Windhorst, C. Allaart, A. J. Einstein, T. Khawaja, C. Greer, A. Chokshi, M. Jones, K. Schaefle, K. Bhatia, D. Shimbo, P. C. Schulze, A. Srivastava, R. Chettiar, J. Moody, C. Weyman, D. Natale, W. Bruni, Y. Liu, E. Ficaro, A. J. Sinusas, A. Peix, E. Batista, L. O. Cabrera, K. Padron, L. Rodriguez, B. Sainz, V. Mendoza, R. Carrillo, Y. Fernandez, E. Mena, A. Naum, T. Bach-Gansmo, N. Kleven-Madsen, M. Biermann, B. Johnsen, J. Aase Husby, S. Rotevatn, J. E. Nordrehaug, J. Schaap, R. M. Kauling, M. C. Post, B. J. W. M. Rensing, J. F. Verzijlbergen, J. Sanchez, G. Giamouzis, N. Tziolas, P. Georgoulias, G. Karayannis, A. Chamaidi, N. Zavos, K. Koutrakis, G. Sitafidis, J. Skoularigis, F. Triposkiadis, S. Radovanovic, A. Djokovic, D. V. Simic, M. Krotin, A. Savic-Radojevic, M. Pljesa-Ercegovac, M. Zdravkovic, J. Saponjski, S. Jelic, T. Simic, R. Eckardt, B. J. Kjeldsen, L. I. Andersen, T. Haghfelt, P. Grupe, A. Johansen, B. Hesse, H. Pena, G. Cantinho, M. Wilk, Y. Srour, F. Godinho, N. Zafrir, A. Gutstein, I. Mats, A. Battler, A. Solodky, E. Sari, N. Singh, A. Vara, A. M. Peters, A. De Belder, S. Nair, N. Ryan, R. James, S. Dizdarevic, G. Depuey, M. Friedman, R. Wray, R. Old, H. Babla, B. Chuanyong, J. Maddahi, E. Tragardh Johansson, K. Sjostrand, L. Edenbrandt, S. Aguade-Bruix, G. Cuberas-Borros, M. N. Pizzi, M. Sabate-Fernandez, G. De Leon, D. Garcia-Dorado, J. Castell-Conesa, J. Candell-Riera, D. Casset-Senon, M. Edjlali-Goujon, D. Alison, A. Delhommais, P. Cosnay, C. S. Low, A. Notghi, J. O'brien, A. C. Tweddel, N. Bingham, P. O Neil, M. Harbinson, O. Lindner, W. Burchert, M. Schaefers, C. Marcassa, R. Campini, P. Calza, O. Zoccarato, A. Kisko, J. Kmec, M. Babcak, M. Vereb, M. Vytykacova, J. Cencarik, P. Gazdic, J. Stasko, A. Abreu, E. Pereira, L. Oliveira, P. Colarinha, V. Veloso, I. Enriksson, G. Proenca, P. Delgado, L. Rosario, J. Sequeira, I. Kosa, I. Vassanyi, C. S. Egyed, G. Y. Kozmann, S. Morita, M. Nanasato, I. Nanbu, Y. Yoshida, H. Hirayama, A. Allam, A. Sharef, I. Shawky, M. Farid, M. Mouden, J. P. Ottervanger, J. R. Timmer, M. J. De Boer, S. Reiffers, P. L. Jager, S. Knollema, G. M. Nasr, M. Mohy Eldin, M. Ragheb, I. Casans-Tormo, R. Diaz-Exposito, F. J. Hurtado-Mauricio, R. Ruano, M. Diego, F. Gomez-Caminero, C. Albarran, A. Martin De Arriba, A. Rosero, R. Lopez, C. Martin Luengo, J. R. Garcia-Talavera, I. E. K. Laitinen, M. Rudelius, E. Weidl, G. Henriksen, H. J. Wester, M. Schwaiger, X. B. Pan, T. Schindler, A. Quercioli, H. Zaidi, O. Ratib, J. M. Declerck, E. Alexanderson Rosas, R. Jacome, M. Jimenez-Santos, E. Romero, M. A. Pena-Cabral, A. Meave, J. Gonzalez, F. Rouzet, L. Bachelet, J. M. Alsac, M. Suzuki, L. Louedec, A. Petiet, F. Chaubet, D. Letourneur, J. B. Michel, D. Le Guludec, A. Aktas, A. Cinar, G. Yaman, T. Bahceci, K. Kavak, A. Gencoglu, A. Jimenez-Heffernan, E. Sanchez De Mora, J. Lopez-Martin, R. Lopez-Aguilar, C. Ramos, C. Salgado, A. Ortega, C. Sanchez-Gonzalez, J. Roa, A. Tobaruela, S. V. Nesterov, O. Turta, M. Maki, C. Han, D. Daou, M. Tawileh, S. O. Chamouine, C. Coaguila, E. Mariscal-Labrador, N. Kisiel-Gonzalez, P. De Araujo Goncalves, P. J. Sousa, H. Marques, J. O'neill, J. Pisco, R. Cale, J. Brito, A. Gaspar, F. P. Machado, J. Roquette, M. Martinez, G. Melendez, E. Kimura, J. M. Ochoa, A. M. Alessio, A. Patel, R. Lautamaki, F. M. Bengel, J. B. Bassingthwaighte, J. H. Caldwell, K. Rahbar, H. Seifarth, M. Schafers, L. Stegger, T. Spieker, A. Hoffmeier, D. Maintz, H. Scheld, O. Schober, M. Weckesser, H. Aoki, I. Matsunari, K. Kajinami, M. Martin Fernandez, M. Barreiro Perez, O. V. Fernandez Cimadevilla, D. Leon Duran, E. Velasco Alonso, J. P. Florez Munoz, L. H. Luyando, C. Templin, C. E. Veltman, J. H. C. Reiber, S. Venuraju, A. Yerramasu, S. Atwal, A. Lahiri, T. Kunimasa, M. Shiba, K. Ishii, J. Aikawa, E. S. J. Kroner, K. T. Ho, Q. W. Yong, K. C. Chua, C. Panknin, C. J. Roos, J. M. Van Werkhoven, A. J. Witkowska-Grzeslo, M. J. Boogers, D. V. Anand, D. Dey, D. Berman, F. Mut, R. Giubbini, L. Lusa, T. Massardo, A. Iskandrian, M. Dondi, A. Sato, Y. Kakefuda, E. Ojima, T. Adachi, A. Atsumi, T. Ishizu, Y. Seo, M. Hiroe, K. Aonuma, M. Kruk, R. Pracon, C. Kepka, J. Pregowski, A. Kowalewska, M. Pilka, M. Opolski, I. Michalowska, Z. Dzielinska, M. Demkow, V. Stoll, N. Sabharwal, A. Chakera, O. Ormerod, H. Fernandes, M. Bernardes, E. Martins, P. Oliveira, T. Vieira, G. Terroso, A. Oliveira, T. Faria, F. Ventura, J. Pereira, S. Fukuzawa, M. Inagaki, J. Sugioka, A. Ikeda, S. Okino, J. Maekawa, T. Uchiyama, N. Kamioka, S. Ichikawa, M. Afshar, R. Alvi, N. Aguilar, R. Ippili, H. Shaqra, J. Bella, N. Bhalodkar, A. Dos Santos, M. Daicz, L. O. Cendoya, H. G. Marrero, J. Casuscelli, M. Embon, G. Vera Janavel, E. Duronto, E. P. Gurfinkel, C. M. Cortes, Y. Takeishi, K. Nakajima, Y. Yamasaki, T. Nishimura, K. Hayes Brown, F. Collado, M. Alhaji, J. Green, S. Alexander, R. Vashistha, S. Jain, F. Aldaas, J. Shanes, R. Doukky, K. Ashikaga, Y. J. Akashi, M. Uemarsu, R. Kamijima, K. Yoneyama, K. Omiya, Y. Miyake, Y. Brodov, U. Raval, A. Berezin, V. Seden, E. Koretskaya, T. A. Panasenko, S. Matsuo, S. Kinuya, J. Chen, R. J. Van Bommel, B. Van Der Hiel, P. Dibbets-Schneider, E. V. Garcia, I. Rutten-Vermeltfoort, M. M. J. Gevers, B. Verhoeven, A. B. Dijk Van, E. Raaijmakers, P. G. H. M. Raijmakers, J. E. Engvall, M. Gjerde, J. De Geer, E. Olsson, P. Quick, A. Persson, M. Mazzanti, M. Marini, L. Pimpini, G. P. Perna, C. Marciano, P. Gargiulo, M. Galderisi, C. D'amore, G. Savarese, L. Casaretti, S. Paolillo, A. Cuocolo, P. Perrone Filardi, M. Al-Amoodi, E. C. Thompson, K. Kennedy, K. A. Bybee, A. I. Mcghie, J. H. O'keefe, T. M. Bateman, R. L. F. Van Der Palen, A. M. Mavinkurve-Groothuis, B. Bulten, L. Bellersen, H. W. M. Van Laarhoven, L. Kapusta, L. F. De Geus-Oei, P. P. Pollice, M. B. Bonifazi, F. P. Pollice, I. P. Clements, D. O. Hodge, C. G. Scott, M. De Ville De Goyet, B. Brichard, T. Pirotte, S. Moniotte, R. A. Tio, A. Elvan, R. A. I. O. Dierckx, R. H. J. A. Slart, T. Furuhashi, M. Moroi, H. Hase, N. Joki, H. Masai, R. Nakazato, H. Fukuda, K. Sugi, K. Kryczka, E. Kaczmarska, J. Petryka, L. Mazurkiewicz, W. Ruzyllo, P. Smanio, E. Vieira Segundo, M. Siqueira, J. Kelendjian, J. Ribeiro, J. Alaca, M. Oliveira, F. Alves, I. Peovska, J. Maksimovic, M. Vavlukis, N. Kostova, D. Pop Gorceva, V. Majstorov, M. Zdraveska, S. Hussain, M. Djearaman, E. Hoey, L. Morus, O. Erinfolami, A. Macnamara, M. P. Opolski, A. Witkowski, V. Berti, F. Ricci, R. Gallicchio, W. Acampa, G. Cerisano, C. Vigorito, R. Sciagra', A. Pupi, H. Sliem, F. M. Collado, S. Schmidt, A. Maheshwari, R. Kiriakos, V. Mwansa, S. Ljubojevic, S. Sedej, M. Holzer, G. Marsche, V. Marijanski, J. Kockskaemper, B. Pieske, A. Ricalde, G. Alexanderson, A. Mohani, P. Khanna, A. Sinusas, F. Lee, V. A. Pinas, B. L. F. Van Eck-Smit, H. J. Verberne, C. M. De Bruin, G. Guilhermina, L. Jimenez-Angeles, O. Ruiz De Jesus, O. Yanez-Suarez, E. Vallejo, E. Reyes, M. Chan, M. L. Hossen, S. R. Underwood, A. Karu, S. Bokhari, V. Pineda, L. M. Gracia-Sanchez, A. Garcia-Burillo, K. Zavadovskiy, Y. U. Lishmanov, W. Saushkin, I. Kovalev, A. Chernishov, A. Annoni, M. Tarkia, T. Saanijoki, V. Oikonen, T. Savunen, M. A. Green, M. Strandberg, A. Roivainen, M. C. Gaeta, C. Artigas, J. Deportos, L. Geraldo, A. Flotats, V. La Delfa, I. Carrio, W. J. Laarse, M. M. Izquierdo Gomez, J. Lacalzada Almeida, A. Barragan Acea, A. De La Rosa Hernandez, R. Juarez Prera, G. Blanco Palacios, J. A. Bonilla Arjona, J. J. Jimenez Rivera, J. L. Iribarren Sarrias, I. Laynez Cerdena, A. Dedic, A. Rossi, G. J. R. Ten Kate, A. Dharampal, A. Moelker, T. W. Galema, N. Mollet, P. J. De Feyter, K. Nieman, D. Trabattoni, A. Broersen, M. Frenay, M. M. Boogers, P. H. Kitslaar, J. Dijkstra, D. A. Annoni, M. Muratori, N. Johki, M. Tokue, A. S. Dharampal, A. C. Weustink, L. A. E. Neefjes, S. L. Papadopoulou, C. Chen, N. R. A. Mollet, E. H. Boersma, G. P. Krestin, J. A. Purvis, D. Sharma, S. M. Hughes, D. S. Berman, R. Taillefer, J. Udelson, M. Devine, J. Lazewatsky, G. Bhat, D. Washburn, D. Patel, T. Mazurek, S. Tandon, S. Bansal, S. Inzucchi, L. Staib, J. Davey, D. Chyun, L. Young, F. Wackers, M. T. Harbinson, G. Wells, J. Dougan, S. Borges-Neto, H. Phillips, A. Farzaneh-Far, Z. Starr, L. K. Shaw, M. Fiuzat, C. O'connor, M. Henzlova, W. L. Duvall, A. Levine, U. Baber, L. Croft, S. Sahni, S. Sethi, L. Hermann, A. Nureldin, A. Gomaa, M. A. T. Soliman, H. A. R. Hany, F. De Graaf, A. Pazhenkottil, H. M. J. Siebelink, J. H. Reiber, M. Ayub, T. Naveed, M. Azhar, A. Van Tosh, T. L. Faber, J. R. Votaw, N. Reichek, B. Pulipati, C. Palestro, K. J. Nichols, K. Okuda, Y. Kirihara, T. Ishikawa, J. Taki, M. Yoshita, M. Yamada, A. Salacata, S. Keavey, V. Chavarri, J. Mills, H. Nagaraj, P. Bhambhani, D. E. Kliner, P. Soman, J. Heo, A. E. Iskandrian, M. Jain, B. Lin, A. Walker, C. Nkonde, S. Bond, A. Baskin, J. Declerck, M. E. Soto, G. Mendoza, M. Aguilar, S. P. Williams, G. Colice, J. R. Mcardle, A. Lankford, D. K. Kajdasz, C. R. Reed, L. Angelini, F. Angelozzi, G. Ascoli, A. Jacobson, H. J. Lessig, M. C. Gerson, M. D. Cerqueira, J. Narula, M. Uematsu, K. Kida, K. Suzuki, P. E. Bravo, K. Fukushima, M. Chaudhry, J. Merrill, A. Alonso Tello, J. F. Rodriguez Palomares, G. Marti Aguasca, S. Aguade Bruix, V. Aliaga, P. Mahia, T. Gonzalez-Alujas, J. Candell, A. Evangelista, R. Mlynarski, A. Mlynarska, M. Sosnowski, B. Zerahn, P. Hasbak, C. E. Mortensen, H. F. Mathiesen, M. Andersson, D. Nielsen, L. Ferreira Santos, M. J. Ferreira, D. Ramos, D. Moreira, M. J. Cunha, A. Albuquerque, A. Moreira, J. Oliveira Santos, G. Costa, L. A. Providencia, Y. Arita, S. Kihara, N. Mitsusada, M. Miyawaki, H. Ueda, H. Hiraoka, Y. Matsuzawa, J. Askew, M. O'connor, L. Jordan, R. Ruter, R. Gibbons, T. Miller, L. Emmett, A. Ng, N. Sorensen, R. Mansberg, L. Kritharides, T. Gonzalez, H. Majmundar, N. P. Coats, S. Vernotico, J. H. Doan, T. M. Hernandez, M. Evini, A. D. Hepner, T. K. Ip, W. A. Chalela, A. M. Falcao, L. O. Azouri, J. A. F. Ramires, J. C. Meneghetti, F. Manganelli, M. Spadafora, P. Varrella, G. Peluso, R. Sauro, E. Di Lorenzo, F. Rotondi, S. Daniele, P. Miletto, A. J. M. Rijnders, B. W. Hendrickx, W. Van Der Bruggen, Y. G. C. J. America, P. J. Thorley, F. U. Chowdhury, C. J. Dickinson, S. I. Sazonova, I. Y. U. Proskokova, A. M. Gusakova, S. M. Minin, Y. U. B. Lishmanov, V. V. Saushkin, G. Rodriguez, F. Roffe, H. Ilarraza, D. Bialostozky, A. N. Kitsiou, P. Arsenos, I. Tsiantis, S. Charizopoulos, S. Karas, R. C. Vidal Perez, M. Garrido, V. Pubul, S. Argibay, C. Pena, M. Pombo, A. B. Ciobotaru, A. Sanchez-Salmon, A. Ruibal Morell, J. R. Gonzalez-Juanatey, E. Rodriguez-Gomez, B. Martinez, D. Pontillo, F. Benvissuto, F. Fiore Melacrinis, S. Maccafeo, E. V. Scabbia, R. Schiavo, Y. Golzar, C. Gidea, J. Golzar, D. Pop-Gorceva, M. Zdravkovska, S. Stojanovski, L. J. Georgievska-Ismail, T. Katsikis, A. Theodorakos, A. Kouzoumi, M. Koutelou, Y. Yoshimura, T. Toyama, H. Hoshizaki, S. Ohshima, M. Inoue, T. Suzuki, A. Uitterdijk, M. Dijkshoorn, M. Van Straten, W. J. Van Der Giessen, D. J. Duncker, D. Merkus, G. Platsch, J. Sunderland, C. Tonge, P. Arumugam, T. Dey, H. Wieczorek, R. Bippus, R. L. Romijn, B. E. Backus, T. Aach, M. Lomsky, L. Johansson, J. Marving, S. Svensson, J. L. Pou, F. P. Esteves, P. Raggi, R. Folks, Z. Keidar, J. W. Askew, L. Verdes, L. Campos, V. Gulyaev, A. Pankova, J. Santos, S. Carmona, I. Henriksson, A. Prata, M. Carrageta, A. I. Santos, K. Yoshinaga, M. Naya, C. Katoh, O. Manabe, S. Yamada, H. Iwano, S. Chiba, H. Tsutsui, N. Tamaki, I. Vassiliadis, E. Despotopoulos, O. Kaitozis, E. Hatzistamatiou, R. Thompson, J. Hatch, M. Zink, B. S. Gu, G. D. Bae, C. M. Dae, G. H. Min, E. J. Chun, S. I. Choi, M. Al-Mallah, K. Kassem, O. Khawaja, D. Goodman, D. Lipkin, L. Christiaens, B. Bonnet, J. Mergy, D. Coisne, J. Allal, N. Dias Ferreira, D. Leite, J. Rocha, M. Carvalho, D. Caeiro, N. Bettencourt, P. Braga, V. Gama Ribeiro, U. S. Kristoffersen, A. M. Lebech, H. Gutte, R. S. Ripa, N. Wiinberg, C. L. Petersen, G. Jensen, A. Kjaer, C. Bai, R. Conwell, R. D. Folks, L. Verdes-Moreiras, D. Manatunga, A. F. Jacobson, D. Belzer, Y. Hasid, M. Rehling, R. H. Poulsen, L. Falborg, J. T. Rasmussen, L. N. Waehrens, C. W. Heegaard, J. M. U. Silvola, S. Forsback, J. O. Laine, S. Heinonen, S. Ylaherttuala, A. Broisat, M. Ruiz, N. C. Goodman, J. Dimastromatteo, D. K. Glover, F. Hyafil, F. Blackwell, G. Pavon-Djavid, L. Sarda-Mantel, L. J. Feldman, A. Meddahi-Pelle, V. Tsatkin, Y.- H. Liu, R. De Kemp, P. J. Slomka, R. Klein, G. Germano, R. S. Beanlands, A. Rohani, V. Akbari, J. G. J. Groothuis, M. Fransen, A. M. Beek, S. L. Brinckman, M. R. Meijerink, M. B. M. Hofman, C. Van Kuijk, S. Kogure, E. Yamashita, J. Murakami, R. Kawaguchi, H. Adachi, S. Oshima, S. Minin, S. Popov, Y. U. Saushkina, G. Savenkova, D. Lebedev, E. Alexandridis, D. Rovithis, C. Parisis, I. Sazonova, V. Saushkin, V. Chernov, L. Zaabar, H. Bahri, S. Hadj Ali, A. Sellem, I. Slim, N. El Kadri, H. Slimen, H. Hammami, S. Lucic, A. Peter, S. Tadic, K. Nikoletic, R. Jung, M. Lucic, K. Tagil, D. Jakobsson, S.- E. Svensson, P. Wollmer, L. Leccisotti, L. Indovina, L. Paraggio, M. L. Calcagni, A. Giordano, M. Kapitan, A. Paolino, M. Nunez, J. Sweeny, N. Kulkarni, K. Guma, Y. Akashi, M. Takano, M. Takai, S. Koh, F. Miyake, N. Torun, G. Durmus Altun, A. Altun, E. Kaya, H. Saglam, D. T. Matsuoka, A. Sanchez, C. Bartolozzi, D. Padua, G. Ponta, A. Ponte, A. Carneiro, A. Thom, R. Ashrafi, P. Garg, G. Davis, A. Falcao, M. Costa, F. Bussolini, J. A. C. Meneghetti, M. Tobisaka, E. Correia, J. W. Jansen, P. A. Van Der Vleuten, T. P. Willems, F. Zijlstra, M. Sato, K. Taniguchi, M. Kurabayashi, D. Pop Gjorcheva, M. Zdraveska-Kochovska, K. Moriwaki, A. Kawamura, K. Watanabe, T. Omura, S. Sakabe, T. Seko, A. Kasai, M. Ito, M. Obana, T. Akasaka, C. Hruska, D. Truong, C. Pletta, D. Collins, C. Tortorelli, D. Rhodes, M. El-Prince, A. Martinez-Moeller, M. Marinelli, S. Weismueller, C. Hillerer, B. Jensen, S. G. Nekolla, H. Wakabayashi, K. Tsukamoto, S. M. E. A. Baker, K. M. H. S. Sirajul Haque, A. Siddique, S. Krishna Banarjee, A. Ahsan, F. Rahman, M. Mukhlesur Rahman, T. Parveen, M. Lutfinnessa, F. Nasreen, H. Sano, S. Naito, M. L. De Rimini, G. Borrelli, F. Baldascino, P. Calabro, C. Maiello, A. Russo, C. Amarelli, P. Muto, I. Danad, P. G. Raijmakers, Y. E. Appelman, O. S. Hoekstra, J. T. Marcus, A. Boonstra, D. V. Ryzhkova, T. V. Kuzmina, O. S. Borodina, M. A. Trukshina, I. S. Kostina, H. Hommel, G. Feuchtner, O. Pachinger, G. Friedrich, A. M. Stel, J. W. Deckers, V. Gama, A. Ciarka, L. A. Neefjes, N. R. Mollet, E. J. Sijbrands, J. Wilczek, C. Llibre Pallares, O. Abdul-Jawad Altisent, H. Cuellar Calabria, P. Mahia Casado, M. T. Gonzalez-Alujas, A. Evangelista Masip, D. Garcia-Dorado Garcia, Y. Tekabe, X. Shen, Q. Li, J. Luma, D. Weisenberger, A. M. Schmidt, R. Haubner, L. Johnson, L. Sleiman, S. Thorn, M. Hasu, M. Thabet, J. N. Dasilva, S. C. Whitman, D. Genovesi, A. Giorgetti, A. Gimelli, G. Cannizzaro, F. Bertagna, G. Fagioli, M. Rossi, R. Bonini, P. Marzullo, C. A. Paterson, S. A. Smith, A. D. Small, N. E. R. Goodfield, W. Martin, S. Nekolla, H. Sherif, S. Reder, M. Yu, A. Kusch, D. Li, J. Zou, M. S. Lloyd, K. Cao, D. W. Motherwell, A. Rice, G. M. Mccurrach, S. M. Cobbe, M. C. Petrie, I. Al Younis, E. Van Der Wall, T. Mirza, M. Raza, H. Hashemizadeh, L. Santos, B. A. Krishna, F. Perna, M. Lago, M. Leo, G. Pelargonio, G. Bencardino, M. L. Narducci, M. Casella, F. Bellocci, S. Kirac, O. Yaylali, M. Serteser, T. Yaylali, A. Okizaki, Y. Urano, M. Nakayama, S. Ishitoya, J. Sato, Y. Ishikawa, M. Sakaguchi, N. Nakagami, T. Aburano, S. V. Solav, R. Bhandari, S. Burrell, S. Dorbala, I. Bruno, C. Caldarella, A. Collarino, M. V. Mattoli, A. Stefanelli, A. Cannarile, F. Maggi, V. Soukhov, S. Bondarev, A. Yalfimov, M. Khan, P. P. Priyadharshan, G. Chandok, T. Aziz, M. Avison, R. A. Smith, D. S. Bulugahapitya, T. Vakhtangadze, F. Todua, M. Baramia, G. Antelava, N.- C. Roche, P. Paule, S. Kerebel, J.- M. Gil, L. Fourcade, A. Tzonevska, K. Tzvetkov, M. Atanasova, V. Parvanova, A. Chakarova, E. Piperkova, B. Kocabas, H. Muderrisoglu, C. P. Allaart, E. Entok, S. Simsek, B. Akcay, I. Ak, E. Vardareli, M. Stachura, P. J. Kwasiborski, G. J. Horszczaruk, E. Komar, A. Cwetsch, B. Zraik, R. Morales Demori, A. D. J. Almeida, M. E. Siqueira, E. Vieira, I. Balogh, G. Kerecsen, E. Marosi, Z. S. Szelid, A. Sattar, T. Swadia, J. Chattahi, W. Qureshi, F. Khalid, A. Gonzalez, S. Hechavarria, K. Takamura, S. Fujimoto, R. Nakanishi, S. Yamashina, A. Namiki, J. Yamazaki, K. Koshino, Y. Hashikawa, N. Teramoto, M. Hikake, S. Ishikane, T. Ikeda, H. Iida, Y. Takahashi, N. Oriuchi, H. Higashino, K. Endo, T. Mochizuki, K. Murase, A. Baali, R. Moreno, M. Chau, H. Rousseau, F. Nicoud, P. Dolliner, L. Brammen, G. Steurer, T. Traub-Weidinger, P. Ubl, P. Schaffarich, G. Dobrozemsky, A. Staudenherz, M. Ozgen Kiratli, B. Temelli, N. B. Kanat, T. Aksoy, G. A. Slavich, G. Piccoli, M. Puppato, S. Grillone, D. Gasparini, S. Perruchoud, C. Poitry-Yamate, M. Lepore, R. Gruetter, T. Pedrazzini, D. Anselm, A. Anselm, H. Atkins, J. Renaud, R. Dekemp, I. Burwash, A. Guo, R. Beanlands, C. Glover, I. Vilardi, B. Zangheri, L. Calabrese, P. Romano, A. Bruno, O. C. Fernandez Cimadevilla, V. A. Uusitalo, M. Luotolahti, M. Wendelin-Saarenhovi, J. Sundell, O. Raitakari, S. Huidu, R. Gadiraju, M. Ghesani, Q. Uddin, B. Wosnitzer, N. Takahashi, E. Alhaj, A. Legasto, B. Abiri, K. Elsaban, T. El Khouly, T. El Kammash, A. Al Ghamdi, B. Kyung Deok, K. Bon Seung, Y. Sang Geun, D. Chang Min, and M. Gwan Hong

Subjects
Cardiology and Cardiovascular Medicine
Published
2011

45. Multiple sclerosis (PP-038)

Author

G. Fragoso, Christina Elliott, A. H. Nuyts, Y. Miyazaki, Y. Xu, T. Okazawa, H. Ochi, Y. Matsui, E. Montero, A. Mirshafiey, M. Izad, G. Lee, K. Fukuda, B. Balint, H. Kurata, A. Daniel Beyeen, E. S. Patrício, A. C. La Flamme, K. Shimano, T. Corona, H. Dougier-Reynaud, S. Miyake, H. Perron, T. Derfuss, E. Jouvin-Marche, T. Uede, D. O'Sulllivan, M. Hong, Reinhard Hohlfeld, S. Mader, M. Korporal, Z. Tan, R. Melarkode, S. Zhang, R. C. Dutra, Y. Lapierre, Z. Hruskova, T. Sugita, J. B. Pesquero, Z. N. Berneman, E. Kamali-Sarvestani, M. Khademi, P. Sämann, M. Trneny, M. Kadowaki, D. L. De la Cruz-Aguilera, B. Wildemann, H. Shinya, G. Nagels, Keyvan Ghasami, I. Kovarova, S. Vishwakarma, H. Mareckova, A. F. Bento, F. Gong, J. Gibbons, L. Duan, E. Zastepa, L. Aguirre-Cruz, D. Ganea, A. Tomita, A. Bar-Or, J. Antel, V. F. I. Van Tendeloo, J. Yen, D. Haegert, J. Hong, N. Yasuharu, L. Lee, C. Yao, J. Morimoto, Y. Yang, T. Okamoto, D. Sakata, J. Flores-Rivera, Ariel Arthur, Payani, Y. Esaki, J. K. M. Ng, M. Jagodic, Edgar Meinl, M. Krantz, Hema Mohan, Hartmut Wekerle, S. Jeon, J. Kira, I. Takaaki, M. Yanagida, M. Kharkrang, C. P. Figueiredo, W. Ma, T. S. Balmukhanov, M. Harirchian, N. Chihara, T. Yamamura, S. Satoru, Y. Miyamoto, K. Lenders, D. Hong, E. Krasulova, F. Zheng, W. Sato, M. Fang, L. Skacikova, N. Isobe, Z. Gheflati, B. Connor, D. Kurotaki, M. Ogawa, T. Olsson, E. Havrdova, H. Amiri Fard, Susan C. Barnett, S. Narumiya, J. Malotka, L. Chapul, L. Fitz-Gerald, J. Lee, B. Fritz, K. Motomura, T. Matsuoka, G. Tu, D. F. P. Leite, M. Koyama, H. Choi, K. Zenichiro, Ghasem Mosayebi, A. Fukunari, P. N. Marche, N. Seki, K. Ito, M. Vessal, E. Segi-Nishida, C. Bernard, Y. Kim, U. Makoto, P. Li, Y. Li, B. Agrawal, B. Willekens, A. Nikseresht, S. Zoghi, M. Minohara, Klaus Dornmair, X. Zeng, J. B. Calixto, A. Ortlieb Guerreiro-Cacais, S. Kim, F. Najafi, T. Matsushita, N. Cools, C. Lomparski, Yahya Jand, M. Kanayama, L. Steinman, S. Yoshimura, P. Nair, C. L. Villiers, K. Sugahara, Christopher Linington, R. H. Seong, K. Logronio, F. Satoshi, Hans Lassmann, T. Ikeda, H. Uga, M. Shin, M. Reindl, M. Ikeda, M. Rasband, D. Arnold, E. W. Loo, S. Tanaka, A. Duperray, S. He, D. Zhang, A. A. Smagin, N. A. Aitkhozhina, H. Kataoka, M. B. D'hooghe, J. Haas, R. Axtell, Z. Amirghofran, I. A. Goldina, Y. Funahashi, K. Chiba, M. r. Khazaei, T. Aranami, Ali Ghazavi, M. N. Manjavachi, F. Weber, S. M. Jeong, S. Patel, J. Lin, B. Stein, H. Bae, Y. Maeda, M. A. Mendesh, A. Schwarz, A. Jamshidian, Markus Krumbholz, K. Van Camp, and T. Berger

Subjects
Oncology, medicine.medical_specialty, business.industry, Multiple sclerosis, Internal medicine, Immunology, medicine, Immunology and Allergy, General Medicine, medicine.disease, business
Published
2010

46. Correction to 'Total Synthesis of (−)-Sarain A'

Author

Larry E. Overman, Fay Ng, Sheldon Hiebert, Christopher J. Douglas, Robert Downham, Peter Chua, Neil K. Garg, Joy A. Middleton, Richard T. Matsuoka, Stefan Jaroch, and Michael Becker

Subjects
Colloid and Surface Chemistry, 010405 organic chemistry, Chemistry, Published Erratum, Chemical Sciences, General Chemistry, 010402 general chemistry, 01 natural sciences, Biochemistry, Humanities, Catalysis, 0104 chemical sciences
Abstract

Author(s): Becker, Michael H; Chua, Peter; Downham, Robert; Douglas, Christopher J; Garg, Neil K; Hiebert, Sheldon; Jaroch, Stefan; Matsuoka, Richard T; Middleton, Joy A; Ng, Fay W; Overman, Larry E

Published
2018

47. Simple Method to Determine Which Barley Cultivar Is Suitable for Roasted Barley Tea

Author

T. Matsuoka, N. Ayuzawa, and T. Kobayashi

Subjects
biology, Agronomy, Genetics, Cultivar, biology.organism_classification, Agronomy and Crop Science, Aroma, Food Science, Roasting, Mathematics
Abstract

麦茶加工適性の高い大麦品種の識別を目的に，原料大麦の簡易分析と焙煎後の粉砕L値が30となるように同一条件で焙煎試験を行い，得られた焙煎大麦と原料大麦の分析値の相関を調査した．その結果，千粒重と麦茶抽出液の吸光度に高い負の相関が認められた．また，麦茶抽出液の官能評価を行った結果，タンパク質含量が高いほど，風味及び香りが強いという傾向が認められた．これらの結果から，風味や香りに大きな影響を与える成分と麦茶の色に大きな影響を与える成分が異なると考えた．すなわち，風味や香りにはタンパク質が焙煎により褐色反応を起こすメイラード反応の影響が強く，麦茶抽出液の吸光度には糖質の褐色反応であるカラメル反応が大きく起因していると推測した．

Published
2010

50. Kuroshio variations in the upstream region as seen by HF radar and satellite altimetry data

Author

T. Matsuoka, Motohiko Kashima, Ryoko Tokeshi, Satoshi Fujii, Kenji Sato, Shoichiro Kojima, and Kaoru Ichikawa

Subjects
Dynamic height, law, Climatology, Anomaly (natural sciences), Ocean current, Mesoscale meteorology, General Earth and Planetary Sciences, Satellite, Altimeter, Radar, Far East, Geology, law.invention
Abstract

Variations of the position and speed of the Kuroshio are studied by a combination of high-resolution high-frequency (HF) ocean radar data and wide-coverage altimetry data. The speed of the Kuroshio and its position are determined along 123.35° E northeast of Taiwan from daily maps of surface geostrophic velocity estimated from HF radar data from August 2001 to February 2005. These two are found to be well correlated for mesoscale variations with periods of a few months, as the Kuroshio tends to be faster (or slower) when its axis moves south (or north). This tendency is significant in summer when the Kuroshio is seasonally intensified and well-defined in the HF radar data. By taking correlation with the sea surface dynamic height anomaly observed by satellite altimeters, these Kuroshio variations in the East China Sea are found to be induced by merging of mesoscale eddies from the east at 21° N and by coincident Kuroshio meanders east of Taiwan.

Published
2008

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