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5. Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry

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Jitendra PS. Sawhney, Veerappa A. Kothiwale, Vikas Bisne, Rajashekhar Durgaprasad, Praveen Jadhav, Manoj Chopda, Velam Vanajakshamma, Ramdhan Meena, Govindan Vijayaraghavan, Kamaldeep Chawla, Jagan Allu, Karen S. Pieper, A. John Camm, Ajay K. Kakkar, Jean-Pierre Bassand, David A. Fitzmaurice, Samuel Z. Goldhaber, Shinya Goto, Sylvia Haas, Werner Hacke, Lorenzo G. Mantovani, Frank Misselwitz, Alexander G.G. Turpie, Martin van Eickels, Freek W.A. Verheugt, Gloria Kayani, Keith A.A. Fox, Bernard J. Gersh, Hector Lucas Luciardi, Harry Gibbs, Marianne Brodmann, Frank Cools, Antonio Carlos Pereira Barretto, Stuart J. Connolly, Alex Spyropoulos, John Eikelboom, Ramon Corbalan, Dayi Hu, Petr Jansky, Jørn Dalsgaard Nielsen, Hany Ragy, Pekka Raatikainen, Jean-Yves Le Heuzey, Harald Darius, Matyas Keltai, Sanjay Kakkar, Jitendra Pal Singh Sawhney, Giancarlo Agnelli, Giuseppe Ambrosio, Yukihiro Koretsune, Carlos Jerjes Sánchez Díaz, Hugo Ten Cate, Dan Atar, Janina Stepinska, Elizaveta Panchenko, Toon Wei Lim, Barry Jacobson, Seil Oh, Xavier Viñolas, Marten Rosenqvist, Jan Steffel, Pantep Angchaisuksiri, Ali Oto, Alex Parkhomenko, Wael Al Mahmeed, David Fitzmaurice, D.Y. Hu, K.N. Chen, Y.S. Zhao, H.Q. Zhang, J.Z. Chen, S.P. Cao, D.W. Wang, Y.J. Yang, W.H. Li, Y.H. Yin, G.Z. Tao, P. Yang, Y.M. Chen, S.H. He, Ying Wang, Yong Wang, G.S. Fu, X. Li, T.G. Wu, X.S. Cheng, X.W. Yan, R.P. Zhao, M.S. Chen, L.G. Xiong, P. Chen, Y. Jiao, Y. Guo, L. Xue, F.Z. Wang, H. Li, Z.M. Yang, C.L. Bai, J. Chen, J.Y. Chen, X. Chen, S. Feng, Q.H. Fu, X.J. Gao, W.N. Guo, R.H. He, X.A. He, X.S. Hu, X.F. Huang, B. Li, J. Li, L. Li, Y.H. Li, T.T. Liu, W.L. Liu, Y.Y. Liu, Z.C. Lu, X.L. Luo, T.Y. Ma, J.Q. Peng, X. Sheng, X.J. Shi, Y.H. Sun, G. Tian, K. Wang, L. Wang, R.N. Wu, Q. Xie, R.Y. Xu, J.S. Yang, L.L. Yang, Q. Yang, Y. Ye, H.Y. Yu, J.H. Yu, T. Yu, H. Zhai, Q. Zhan, G.S. Zhang, Q. Zhang, R. Zhang, Y. Zhang, W.Y. Zheng, B. Zhou, Z.H. Zhou, X.Y. Zhu, S. Kakkar, J.P.S. Sawhney, P. Jadhav, R. Durgaprasad, A.G. Ravi Shankar, R.K. Rajput, K. Bhargava, R. Sarma, A. Srinivas, D. Roy, U.M. Nagamalesh, M. Chopda, R. Kishore, G. Kulkarni, P. Chandwani, R.A. Pothiwala, M. Padinhare Purayil, S. Shah, K. Chawla, V.A. Kothiwale, B. Raghuraman, G. Vijayaraghavan, V.M. Vijan, G. Bantwal, V. Bisne, A. Khan, J.B. Gupta, S. Kumar, D. Jain, S. Abraham, D. Adak, A. Barai, H. Begum, P. Bhattacharjee, M. Dargude, D. Davies, B. Deshpande, P. Dhakrao, V. Dhyani, S. Duhan, M. Earath, A. Ganatra, S. Giradkar, V. Jain, R. Karthikeyan, L. Kasala, S. Kaur, S. Krishnappa, A. Lawande, B. Lokesh, N. Madarkar, R. Meena, P. More, D. Naik, K. Prashanth, M. Rao, N.M. Rao, N. Sadhu, D. Shah, M. Sharma, P. Shiva, S. Singhal, S. Suresh, V. Vanajakshamma, S.G. Panse, Y. Koretsune, S. Kanamori, K. Yamamoto, K. Kumagai, Y. Katsuda, K. Sadamatsu, F. Toyota, Y. Mizuno, I. Misumi, H. Noguchi, S. Ando, T. Suetsugu, M. Minamoto, Hiroshi Oda, K. Shiraishi, S. Adachi, K. Chiba, H. Norita, M. Tsuruta, T. Koyanagi, H. Ando, T. Higashi, K. Okada, S. Azakami, S. Komaki, K. Kumeda, T. Murayama, J. Matsumura, Y. Oba, R. Sonoda, K. Goto, K. Minoda, Y. Haraguchi, H. Suefuji, H. Miyagi, H. Kato, Tadashi Nakamura, Tsugihiro Nakamura, H. Nandate, R. Zaitsu, Yoshihisa Fujiura, A. Yoshimura, H. Numata, J. Ogawa, H. Tatematsu, Y. Kamogawa, K. Murakami, Y. Wakasa, M. Yamasawa, H. Maekawa, S. Abe, H. Kihara, S. Tsunoda, Katsumi Saito, Kazuyuki Saito, T. Fudo, K. Obunai, H. Tachibana, I. Oba, T. Kuwahata, S. Higa, M. Gushiken, T. Eto, H. Yoshida, D. Ikeda, Yoshitake Fujiura, M. Ishizawa, M. Nakatsuka, K. Murata, C. Ogurusu, M. Shimoyama, M. Akutsu, I. Takamura, F. Hoshino, N. Yokota, T. Iwao, K. Tsuchida, M. Takeuchi, Y. Hatori, Y. Kitami, Yoichi Nakamura, R. Oyama, M. Ageta, Hiroyuki Oda, Y. Go, K. Mishima, T. Unoki, S. Morii, Yuhei Shiga, H. Sumi, T. Nagatomo, K. Sanno, K. Fujisawa, Y. Atsuchi, T. Nagoshi, T. Seto, T. Tabuchi, M. Kameko, K. Nii, K. Oshiro, H. Takezawa, S. Nagano, N. Miyamoto, M. Iwaki, Yuichiro Nakamura, M. Fujii, M. Okawa, Masahiko Abe, Masatake Abe, Mitsunori Abe, T. Saito, T. Mito, K. Nagao, J. Minami, T. Mita, I. Sakuma, T. Taguchi, S. Marusaki, H. Doi, M. Tanaka, T. Fujito, M. Matsuta, T. Kusumoto, S. Kakinoki, K. Ashida, N. Yoshizawa, J. Agata, O. Arasaki, M. Manita, M. Ikemura, S. Fukuoka, H. Murakami, S. Matsukawa, Y. Hata, T. Taniguchi, T. Ko, H. Kubo, M. Imamaki, M. Akiyama, M. Inagaki, H. Odakura, T. Ueda, Y. Katsube, A. Nakata, H. Watanabe, M. Techigawara, M. Igarashi, K. Taga, T. Kimura, S. Tomimoto, M. Shibuya, M. Nakano, K. Ito, T. Seo, S. Hiramitsu, H. Hosokawa, M. Hoshiai, M. Hibino, K. Miyagawa, Hajime Horie, N. Sugishita, Yukio Shiga, A. Soma, K. Neya, Tetsuro Yoshida, Tomoki Yoshida, M. Mizuguchi, M. Ishiguro, T. Minagawa, M. Wada, H. Mukawa, F. Okuda, S. Nagasaka, Y. Abe, Sen Adachi, Susumu Adachi, T. Adachi, K. Akahane, T. Amano, K. Aoki, T. Aoyama, H. Arai, S. Arima, T. Arino, H. Asano, T. Asano, J. Azuma, T. Baba, T. Betsuyaku, H. Chibana, H. Date, J. Doiuchi, Y. Emura, M. Endo, Y. Fujii, R. Fujiki, A. Fujisawa, Y. Fujisawa, T. Fukuda, T. Fukui, N. Furukawa, T. Furukawa, W. Furumoto, T. Goto, M. Hamaoka, N. Hanazono, K. Hasegawa, T. Hatsuno, Y. Hayashi, K. Higuchi, K. Hirasawa, H. Hirayama, M. Hirose, S. Hirota, M. Honda, Hideki Horie, T. Ido, O. Iiji, H. Ikeda, K. Ikeda, K. Ikeoka, M. Imaizumi, H. Inaba, T. Inoue, F. Iseki, A. Ishihara, N. Ishioka, N. Ito, T. Iwase, H. Kakuda, J. Kamata, H. Kanai, H. Kanda, M. Kaneko, H. Kano, T. Kasai, T. Kato, Y. Kato, Y. Kawada, K. Kawai, K. Kawakami, S. Kawakami, T. Kawamoto, S. Kawano, J. Kim, T. Kira, H. Kitazawa, H. Kitazumi, T. Kito, T. Kobayashi, T. Koeda, J. Kojima, H. Komatsu, I. Komatsu, Y. Koshibu, T. Kotani, T. Kozuka, Y. Kumai, T. Kumazaki, I. Maeda, K. Maeda, Y. Maruyama, S. Matsui, K. Matsushita, Y. Matsuura, K. Mineoi, H. Mitsuhashi, N. Miura, S. Miyaguchi, S. Miyajima, H. Miyamoto, A. Miyashita, S. Miyata, I. Mizuguchi, A. Mizuno, T. Mori, O. Moriai, K. Morishita, O. Murai, Sho Nagai, Shunichi Nagai, E. Nagata, H. Nagata, A. Nakagomi, S. Nakahara, M. Nakamura, R. Nakamura, N. Nakanishi, T. Nakayama, R. Nakazato, T. Nanke, J. Nariyama, Y. Niijima, H. Niinuma, Y. Nishida, Y. Nishihata, K. Nishino, H. Nishioka, K. Nishizawa, I. Niwa, K. Nomura, S. Nomura, M. Nozoe, T. Ogawa, N. Ohara, M. Okada, K. Okamoto, H. Okita, M. Okuyama, H. Ono, T. Ono, Y. Onuki Pearce, S. Oriso, A. Ota, E. Otaki, Y. Saito, H. Sakai, N. Sakamoto, Y. Sakamoto, Y. Samejima, Y. Sasagawa, H. Sasaguri, A. Sasaki, T. Sasaki, Kazuki Sato, Kiyoharu Sato, M. Sawano, S. Seki, Y. Sekine, Y. Seta, K. Sezaki, N. Shibata, Y. Shiina, H. Shimono, Y. Shimoyama, T. Shindo, H. Shinohara, R. Shinohe, T. Shinozuka, T. Shirai, T. Shiraiwa, Y. Shozawa, T. Suga, C. Sugimoto, Kazuo Suzuki, Keita Suzuki, Shu Suzuki, Shunji Suzuki, Susumu Suzuki, Y. Suzuki, M. Tada, A. Taguchi, T. Takagi, Y. Takagi, K. Takahashi, S. Takahashi, H. Takai, C. Takanaka, S. Take, H. Takeda, K. Takei, K. Takenaka, T. Tana, G. Tanabe, K. Taya, H. Teragawa, S. Tohyo, S. Toru, Y. Tsuchiya, T. Tsuji, K. Tsuzaki, H. Uchiyama, O. Ueda, Y. Ueyama, N. Wakaki, T. Wakiyama, T. Washizuka, M. Watanabe, T. Yamada, T. Yamagishi, H. Yamaguchi, Kenichi Yamamoto, Kentaro Yamamoto, Kunihiko Yamamoto, T. Yamamoto, M. Yamaura, M. Yamazoe, K. Yasui, Y. Yokoyama, K. Yoshida, T.W. Lim, C.K. Ching, C.G. Foo, J.H. Chow, D.D. Chen, F.R. Jaufeerally, Y.M. Lee, G. Lim, W.T. Lim, S. Thng, S.Y. Yap, C. Yeo, S. Oh, H.N. Pak, J.-B. Kim, J.H. Kim, S.-W. Jang, D.H. Kim, D.R. Ryu, S.W. Park, D.-K. Kim, D.J. Choi, Y.S. Oh, M.-C. Cho, S.-H. Kim, H.-K. Jeon, D.-G. Shin, J.S. Park, H.K. Park, S.-J. Han, J.H. Sung, J.-G. Cho, G.-B. Nam, Y.K. On, H.E. Lim, J.J. Kwak, T.-J. Cha, T.J. Hong, S.H. Park, J.H. Yoon, N.-H. Kim, K.-S. Kim, B.C. Jung, G.-S. Hwang, C.-J. Kim, D.B. Kim, J.J. Ahn, H.J. An, H. Bae, A.L. Baek, W.J. Chi, E.A. Choi, E.H. Choi, H.K. Choi, H.S. Choi, S. Han, E.S. Heo, K.O. Her, S.W. Hwang, E.M. Jang, H.-S. Jang, S. Jang, H.-G. Jeon, S.R. Jeon, Y.R. Jeon, H.K. Jeong, I.-A. Jung, Hyeon Jeong Kim, Hyun Ju Kim, Ji Seon Kim, Jung Sook Kim, J.A. Kim, K.T. Kim, M.S. Kim, Sang Hee Kim, Sang Hyun Kim, Y.-I. Kim, C.S. Lee, E.H. Lee, G.H. Lee, H.Y. Lee, H.-Y. Lee, K.H. Lee, K.R. Lee, M.S. Lee, M.-Y. Lee, R.W. Lee, S.E. Lee, S.H. Lee, S. Lee, W.Y. Lee, I.K. Noh, A.R. Park, B.R. Park, H.N. Park, J.H. Park, M. Park, Y. Park, S.-Y. Seo, J. Shim, J.H. Sim, Y.M. Sohn, W.S. Son, Y.S. Son, H.J. Song, H.K. Wi, J.J. Woo, S. Ye, K.H. Yim, K.M. Yoo, E.J. Yoon, S.Y. Yun, P. Angchaisuksiri, S. Chawanadelert, P. Mongkolwongroj, K. Kanokphatcharakun, S. Cheewatanakornkul, T. Laksomya, S. Pattanaprichakul, T. Chantrarat, S. Rungaramsin, S. Silaruks, W. Wongcharoen, K. Siriwattana, K. Likittanasombat, P. Katekangplu, W. Boonyapisit, D. Cholsaringkarl, B. Chatlaong, P. Chattranukulchai, Y. Santanakorn, P. Hutayanon, P. Khunrong, T. Bunyapipat, S. Jai-Aue, P. Kaewsuwanna, P. Bamungpong, S. Gunaparn, S. Hongsuppinyo, R. Inphontan, R. Khattaroek, K. Khunkong, U. Kitmapawanont, C. Kongsin, B. Naratreekoon, S. Ninwaranon, J. Phangyota, A. Phrommintikul, P. Phunpinyosak, K. Pongmorakot, S. Poomiphol, N. Pornnimitthum, S. Pumprueg, S. Ratchasikaew, K. Sanit, K. Sawanyawisuth, B. Silaruks, R. Sirichai, A. Sriwichian, W. Suebjaksing, P. Sukklad, T. Suttana, A. Tangsirira, O. Thangpet, W. Tiyanon, Y. Vorasettakarnkij, T. Wisaratapong, W. Wongtheptien, A. Wutthimanop, S. Yawila, A. Oto, A. Altun, I. Ozdogru, K. Ozdemir, O. Yilmaz, A. Aydinlar, M.B. Yilmaz, E. Yeter, Z. Ongen, M. Cayli, H. Pekdemir, M. Ozdemir, M. Sucu, T. Sayin, M. Demir, H. Yorgun, M. Ersanli, E. Okuyan, D. Aras, H. Abdelrahman, O. Aktas, D. Alpay, F. Aras, M.F. Bireciklioglu, S. Budeyri, M. Buyukpapuc, S. Caliskan, M. Esen, M.A. Felekoglu, D. Genc, B. Ikitimur, E.B. Karaayvaz, S. Kılıç Karataş, S. Okutucu, E. Ozcelik, A. Quisi, H. Sag, L. Sahiner, B.Y. Sayin, T. Seker, D. Uzun Alkan, E. Yildirim, R. Yildirim, F. Yilmaz, V. Yuksekdag, H.L. Luciardi, N. Vensentini, A.C. Ingaramo, G.A. Sambadaro, V. Fernandez Caputi, S.G. Berman, P. Dragotto, A.J. Kleiban, N. Centurion, G. Giacomi, R.A. Ahuad Guerrero, D. Conde, G. Zapata, L.A. Di Paola, J.L. Ramos, R.D. Dran, J. Egido, A.A. Fernandez, M.J. Fosco, S. Sassone, V.A. Sinisi, L.R. Cartasegna, M.A. Berli, O.A. Gomez Vilamajo, F. Ferroni, E.D. Alaguibe, A. Alvarez D'Amelio, C. Arabetti, L. Arias, J.A. Belardi, L. Bergesio, F. Berli, M. Berli, S. Borchowiec, C. Buzzetti, R. Cabrini, V. Campisi, A.L. Cappi, R. Carrizo, F. Colombo Berra, J.P. Costabel, O.J.A. Costamagna, A.A. Damonte, I.N. De Urquiza, F. Diez, M.F. Edén, M. Fanuele, F. Fernandez Voena, M. Foa Torres, C. Funosas, M.P. Giacomi, C.H. Gimenez, E.P. Gurfinkel, M. de L.M. Had, V. Hansen, A.D. Hrabar, M. Ingratta, A. Lopez, G. Maehara, L. Maffei, A. Martinelli, C. Martinelli, J. Matkovich, B. Mautner, A. Meirino, R. Munguia, A. Navarro, V. Novas, G. Perez Prados, J. Pontoriero, R.N. Potito, C. Ricotti, M.A. Rodriguez, F. Rolandi, M.E. Said Palladino, M. Salinger, L.S. Sanziani, P.O. Schygiel, A. Sossich, J.F. Tinto, L. Tonelli, A.L. Tufare, M. Vallejo, M.E. Yunis, M. Zillo, F.J. Zurbrigk, A.C.P. Barretto, D.C. Sobral Filho, J. Jaber, D. Armaganijan, J. Faria Neto, A. Steffens, W. Kunz Sebba Barroso de Souza, J.D. de Souza Neto, J.M. Ribeiro, M. Silveira Teixeira, P.R. Ferreira Rossi, L. Pires, D. Moreira, J.C. Moura Jorge, A. Menezes Lorga Filho, L.C. Bodanese, M. Westerlund Montera, C.H. Del Carlo, T. Da Rocha Rodrigues, F.A. Alves da Costa, A. Lopes, R. Lopes, G.R. Araújo, E.R. Fernandes Manenti, J.F. Kerr Saraiva, J.C. Ferreira Braga, A. Negri, L. Souto, C. Moncada, D. Bertolim Precoma, F. Roquette, G. Reis, R.A. Ramos Filho, E. Lanna Figueiredo, R. Vieira Botelho, C. Munhoz da Fontoura Tavares, C.R. Costantini Frack, J. Abdalla Saad, H.C. Finimundi, C. Pisani, D. Chemello, M. Pereira Martins, C.C. Broilo França, F. Alban, G.B. Aranha Rosito, J.B. de Moura Xavier Moraes Junior, R.T. Tumelero, L. Nigro Maia, R. Simões de Almeida, N.C. do Carmo Borges, L.G. Gomes Ferreira, P. Agliardi, J. Alves de Oliveira Gomes, V. Araujo, M. Arruda Nakazone, T. Barbosa, S. Barroso, E. Belisario Falchetto, H. Bellotti Lopes, M.A. Benez Teixeira Lemos, G. Biazus, L. Borges Queiroz, F.E. Camazzola, M. Caporale, S. Cardoso Boscato, F. Chieza, M.O. Chokr, R. Clemente Mingireanov, N. Codonho Góes, C. Correa, M. Costa, C. Costantini Ortiz, L.S. da Silva, F. da Silva Paulitsch, J.A. da Silveira, E. Daros, G.R. de Araújo, M.I. Del Monaco, C. Dias, M.A. Dias, A.P. Drummond Wainstein, P. Ely Pizzato, D.C. Esteves, P. Fabri, T. Félix Lorenzato Fonseca, E. Fernandes, C. Fonseca, C.R. Frack Costantini, R. Franchin Ferraz, F. Freire, P. Gottardo, D. Guanaes, S. Guizzardi, E. Hettwer Magedanz, F. Igansi, F. Jannuzzi, G. Junior, D. Komar, E.G. Lino, D. Lopes, O. Lourenço da Silva Júnior, E. Lustosa, A.P. Macagnan, M.C. Marinho, M. Mazzoni, G. Melo, L. Mortari, O.M.C.C. Mouco, C. Nanzer Vital, C. Ormundo, S. Oss Emmer, E. Palmegiani, R. Pavani, L. Pereira, V.L. Pereira, R. Perreira, S. Poletti, S.C. Quaia Fortunato, C. Queirantes, N. Ramos Pereira, R.L. Rech, S. Ribeiro, A. Rodrigues, H. Roesch, T. Ruaro Reichert, D. Santos, I. Santos, M. Santos, M.V. Seroqui, S. Silva, L. Soares, L. Spolaor, C. Stoll, N. Toazza Duda, L. Trama, B. Unterkircher, M.V. Valois, T. Vargas, T. Viana, C. Vicente, L. Vidal Armaganijan, R. Vieira Homem, L.G. Vieira Torres, L. Vila Boas, F. Villaça Guimarães Filho, R. Corbalan, G. Eggers, C. Bugueño Gutiérrez, G. Arriagada, S. Potthoff Cardenas, B.A.J. Stockins Fernandez, C. Conejeros, C. Houzvic, P. Marin Cuevas, H. Montecinos, A. Forero, F. Lanas, M. Larico Gómez, G. Charme Vilches, C. Rey, C. Astudillo, J. Aguilar, Y. Campisto, C. Lara, E. Molina, J. Munoz Oyarzon, V. Olguin, M. Vergara, C. Villan, C.J. Sánchez Díaz, J. Illescas Diaz, R. Leal Cantú, M.G. Ramos Zavala, R. Cabrera Jardines, N. Espinola Zavaleta, S. Villarreal Umaña, E. López Rosas, G. Llamas Esperón, G. Pozas, E. Cardona Muñoz, N. Matadamas Hernández, A. Leyva Rendón, N. García Hernández, M. de los Ríos Ibarra, L. Virgen Carrillo, D. López Villezca, C. Hernández Herrera, J.J. López Prieto, R. Gaona Rodríguez, E. Villeda Espinosa, D. Flores Martínez, J. Velasco Barcena, R. Yong, I. Rodríguez Briones, J.L. Leiva Pons, H. Álvarez López, R. Olvera Ruiz, C. Díaz de la Vega, C. Cantú Brito, E. Chuquiure Valenzuela, R. Reyes-Sanchez, A. Bazzoni Ruiz, O. Nandayapa Flores, M. Benavides Gonzalez, R. Arriaga Nava, J.D. Morales Cerda, O. Fierro Fierro, P. Fajardo Campos, T.A.A. Alfaro, S. Altamirano Bellorin, R. Avena, M. Chavarria, I. Espinosa, F. Flores Silva, R.H. Garcia Nava, K. Godoy, E.J. Gonzalez Felix, C.L. Gonzalez Garcia, L.G. Gonzalez Salas, P. Guajardo, S. Hernandez Gonzalez, T. Izquierdo, M.C. Mancilla Ortiz, D. Martinez Vasquez, N. Mendoza, J. Morales, N. Nikitina, S. Ochoa Aybar, A. Ortiz, P. Padilla Macias, F. Perez, J.A. Perez Sanchez, S. Piña Toledano, M. Ramos Gonzalez, C. Rivera Ramos, V. Roa Castro, G. Romero Cardona, M. Ruiz Cornejo, A. Salinas, G. Santana, P. Sida Perez, A.C. Tovar Castaneda, R. Trujillo Cortes, M. Brodmann, K. Lenz, H. Drexel, J. Foechterle, C. Hagn, A. Podczeck-Schweighofer, K. Huber, M. Winkler, B. Schneeweiß, A. Gegenhuber, W. Lang, S. Eichinger-Hasenauer, P. Kaserer, J. Sykora, H. Rasch, M. Pichler, E. Schaflinger, B. Strohmer, R. Breier, K.-M. Ebner, L. Eischer, F. Freihoff, A. Lischka-Lindner, T. Mark, A. Mirtl, A. Said, C. Stöcklöcker, B. Vogel, A. Vonbank, C. Wöhrer, D. Zanolin, F. Cools, G. Paparella, P. Vandergoten, J.-L. Parqué, L. Capiau, G. Vervoort, B. Wollaert, P. Desfontaines, G. Mairesse, T. Boussy, P. Godart, A. De Wolf, J. Voet, A. Heyse, G. Hollanders, W. Anné, J. Vercammen, P. Purnode, I. Blankoff, D. Faes, Y. Balthazar, M. Beutels, P. Maréchal, S. Verstraete, O. Xhaet, H. Striekwold, J. Thoeng, K. Hermans, B. Alzand, A.-K. Ascoop, F. Banaeian, A.-M. Barbuto, A.C. Billiaux, M. Blockmans, C. Bouvy, C. Brike, H. Capiau, T. Casier, A. Conde Y Bolado, D. De Cleen, M. De Coninck, M. de Vos, N. de Weerdt, M. Delforge, M. Delvigne, D. Denie, K. Derycker, E. Deweerd, F. Dormal, S. Drieghe, M. Everaert, T. Eykerman, E. Feys, M. Ghekiere, F. Gits, S. Hellemans, L. Helvasto, C. Jacobs, S. Lips, I. Mestdagh, J. Nimmegeers, V. Piamonte, P. Pollet, A. Postolache, M. Raepers, E. Raymenants, J. Richa, H. Rombouts, J. Salembier, C. Scheurwegs, O. Semeraro, N. Simons, C. Smessaert, W. Smolders, I. Stockman, S. Tahon, V. Thyssen, G. Tincani, F. Van Durme, D. Van Lier, H. Vandekerckhove, Y. Vandekerckhove, D. 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Robiro Robiro, M. Roca, C. Roca Saumell, C. Rodrigo, E. Rodriguez, M. Rodriguez Garcia, S. Saez Jimenez, P. Sanchez Calderon, L. Sanchez Mendez, S. Sanchez Parra, C. Santolaya, M.R. Senan Sanz, A. Seoane Blanco, E. Serralvo, N. Sierra, C. Simon Valero, J. Sorribes Lopez, M. Teixido Fontanillas, M. Terns Riera, G. Tobajas, C. Torres, J. Torres Marques, M. Ubeda Pastor, M. Rosenqvist, A. Wirdby, J. Linden, K. Henriksson, M. Elmersson, A. Egilsson, U. Börjesson, G. Svärd, B. Liu, A. Lindh, L.-B. Olsson, M. Gustavsson, Lars Andersson, Lisbeth Andersson, L. Benson, C. Bothin, A. Hajimirsadeghi, K. Kadir, M. Ericsson, A. Ohlsson, H. Lindvall, P. Svensson, K. Thorne, H. Handel, P. Platonov, B. Eriksson, I. Timberg, K. Romberg, M. Crisby, J.-E. Karlsson, S.A. Jensen, A. Andersson, L. Malmqvist, B. Martinsson, F. Bernsten, J. Engdahl, J. Thulin, A. Hot-Bjelac, P. Stalby, H. Aaröe, E. Ahbeck, H. Ahlmark, F. Al-Khalili, G. Bonkowski, S. Dzeletovic, A.-B. Ekstrand, G.-B. Eriksson, K. Floren, C. Grässjö, S. Hahn, P. Jaensson, B. Jansson, J.-H. Jansson, R.-M. Kangert, A. Koch, D. Kusiak, A. Lettenström, A. Lindberg, C.-J. Lindholm, A. Mannermyr, K. Mansson, M. Millborg, C. Nilsson, A.-M. Ohlin, A. Olofsson, A. Osberg, A. Pedersen, K. Risbecker, K. Rosenberg, J. Samuelsson, M. Shayesteh, K. Skoglund, M. Stjernberg, C. Thorsen, J. Steffel, J.H. Beer, J. Debrunner, D. Amstutz, J. Bruegger, G. Elise, A. Grau, A. Guinand, I. Henriette, E. Saga, S. Winnik, A. Parkhomenko, I. Rudyk, V. Tseluyko, O. Karpenko, S. Zhurba, I. Kraiz, I. Kupnovytska, N. Serediuk, Y. Mostovoy, O. Ushakov, O. Koval, I. Kovalskyi, Y. Svyshchenko, O. Sychov, M. Stanislavchuk, O. Kraydashenko, A. Yagensky, S. Tykhonova, I. Fushtey, R. Belegai, G. Berko, L. Burdeuna, O. Chabanna, I. Daniuk, A. Ivanov, E. Kamenska, P. Kaplan, O. Khyzhnyak, S. Kizim, O. Matova, O. Medentseva, V. Mochonyi, M. Mospan, V. Nemtsova, T. Ovdiienko, O. Palamarchuk, M. Pavelko, R. Petrovskyy, D. Plevak, O. Proshak, S. Pyvovar, L. Rasputina, O. Romanenko, O. Romanova, A. Sapatyi, O. Shumakov, R. Stets, L. Todoriuk, V. Varenov, D. Fitzmaurice, N. Chauhan, D. Goodwin, P. Saunders, R. Evans, J. Leese, P.S. Jhittay, A. Ross, M.S. Kainth, G. Pickavance, J. McDonnell, A. Williams, T. Gooding, H. Wagner, S. Suryani, A. Singal, S. Sircar, R. Bilas, P. Hutchinson, A. Wakeman, M. Stokes, N. Paul, M. Aziz, C. Ramesh, P. Wilson, S. Franklin, S. Fairhead, J. Thompson, V. St Joseph, G. Taylor, D. Tragen, D. Seamark, C. Paul, M. Richardson, A. Jefferies, H. Sharp, H. Jones, C. Giles, M. Page, O. Oginni, J. Aldegather, S. Wetherwell, W. Lumb, P. Evans, F. Scouller, N. Macey, Y. Stipp, R. West, S. Thurston, P. Wadeson, J. Matthews, P. Pandya, A. Gallagher, T. Railton, B. Sinha, D. Russell, J.A. Davies, P. Ainsworth, C.P. Jones, P. Weeks, J. Eden, D. Kernick, W. Murdoch, L. Lumley, R.P. Patel, S.W. Wong, M. Saigol, K. Ladha, K. Douglas, D.F. Cumberlidge, C. Bradshaw, G. Van Zon, K.P. Jones, M.J. Thomas, E. Watson, B. Sarai, N. Ahmad, W. Willcock, J. Cairns, S. Sathananthan, N. de Kare-Silver, A. Gilliland, E. Strieder, A. Howitt, B. Vishwanathan, N. Bird, D. Gray, M. Clark, J. Bisatt, J. Litchfield, E. Fisher, T. Fooks, A.R. Kelsall, E. Alborough, J. Wakeling, M. Parfitt, K. Milne, S. Rogers, R. Priyadharshan, J.L. Oliver, E. Davies, S. Abushal, M. Jacobs, C. Hutton, N.I. Walls, R. Thompson, C. Chigbo, S.M.A. Zaidi, M. Howard, K.C. Butter, S. Barrow, H. Little, I.U. Haq, L. Gibbons, S. Glencross, A.J. McLeod, K. Poland, C. Mulholland, A. Warke, P. Conn, G. Burns, R.N. Smith, S. Lowe, R. Kamath, H.S. Dau, J. Webster, I. Hodgins, S. Vercoe, P.C. Roome, H. Pinnock, J.R.A. Patel, A. Ali, N. Hart, R. Davies, E. Stuart, C.A. Neden, M. Danielsen, R. Heath, P. Sharma, S. Galloway, C. Hawkins, R. Oliver, M. Aylward, S. Mannion, M. Braddick, D. Edwards, A.C. Rothwell, A. Sabir, F. Choudhary, S. Khalaque, A. Wilson, S. Peters, W. Coulson, N. Roberts, A. Heer, S. Coates, B. Ward, D. Jackson, S. Walton, D. Shepherd, M. Sterry, T. Wong, M. Boon, R. Bunney, R. Haria-Shah, R.T. Baron, S. Davies, T. Schatzberger, N. Hargreaves, T. Stephenson, H. Choi, R. Batson, L. Lucraft, T. Myhill, S. Estifano, D. Geatch, J. Wilkinson, R. Veale, K. Forshaw, T. Davies, K. Zaman, P. Vinson, C. Liley, M. Bandrapalli, P. McGinty, R. Wastling, P. McEleny, A. Beattie, P. Cooke, M. Wong, J. Gunasegaram, M. Pugsley, S. Ahmad, C. A'Court, J. Ayers, J. Bennett, S. Cartwright, S. Dobson, C. Dooldeniya, A. Flynn, R. Fox, J. Goram, A. Halpin, A. Hay, P. Jacobs, L. Jeffers, L. Lomax, I. Munro, R. Muvva, M. Nadaph, K. Powell, S. Randfield, D. Redpath, R. Reed, M. Rickenbach, G. Rogers, P.B. Saunders, C. Seamark, J. Shewring, P. Simmons, H. Simper, H. Stoddart, A. Sword, N. Thomas, A. Thomson, H. Gibbs, A. Blenkhorn, B. Singh, W. Van Gaal, W. Abhayaratna, R. Lehman, P. Roberts-Thomson, J. Kilian, D. Coulshed, A. Catanchin, D. Colquhoun, H. Kiat, D. Eccleston, J. French, L. Zimmett, B. Ayres, T. Phan, P. Blombery, D. Crimmins, D. O'Donnell, A. Choi, P. Astridge, M. Arstall, N. Jepson, M. Binnekamp, A. Lee, J. Rogers, G. Starmer, P. Carroll, J. Faunt, A. Aggarwala, L. Barry, C. Batta, R. Beveridge, A. Black, M. Bonner, J. Boys, E. Buckley, M. Campo, L. Carlton, A. Connelly, B. Conway, D. Cresp, H. Dimitri, S. Dixon, M. Dolman, M. Duroux, M. Eskandari, R. Eslick, A. Ferreira-Jardim, T. Fetahovic, D. Fitzpatrick, R. Geraghty, J. Gibbs, T. Grabek, M.H. Modi, K. Hayes, M.P. Hegde, L. Hesketh, B. Hoffmann, B. Jacobson, K. Johnson, C. Juergens, I. Kassam, V. Lawlor, M. Lehman, S. Lehman, D. Leung, S. Mackay, M. MacKenzie, C. McCarthy, C. McIntosh, L. McKeon, H. Morrison, C. Mussap, J.-D. Myers, V. Nagalingam, G. Oldfield, V. O'May, J. Palmer, L. Parsons, K. Patching, T. Patching, V. Paul, M. Plotz, S. Preston, H. Rashad, M. Ratcliffe, S. Raynes, J. Rose, L. Sanders, M. Seremetkoska, H. Setio, S. Shone, P. Shrestha, C. Singh, C. Singleton, N. Stoyanov, S. Sutcliffe, K. Swaraj, J. Tarrant, S. Thompson, I.M. Tsay, M. Vorster, A. Waldman, L. Wallis, E. Wilford, K. Wong, S.J. Connolly, A. Spyropoulos, J. Eikelboom, R. Luton, M. Gupta, A.S. Pandey, S. Cheung, R. Leader, P. Beaudry, F. Ayala-Paredes, J. Berlingieri, J. Heath, G. Poirier, M. Du Preez, R. Nadeau, G. Dresser, R. Dhillon, T. Hruczkowski, B. Schweitzer, B. Coutu, P. Angaran, P. MacDonald, S. Vizel, S. Fikry, R. Parkash, A. Lavoie, J. Cha, B. Ramjattan, J. Bonet, K. Ahmad, L. Aro, T. Aves, K. Beaudry, C. Bergeron, J. Bigcanoe, N. Bignell, L. Breakwell, E. Burke, L. Carroll, B. Clarke, T. Cleveland, S. Daheb, P. Dehghani, I. Denis, Z. Djaidani, P. Dorian, S. Douglass, J. Dunnigan, A. Ewert, D. Farquhar, A. Fearon, L. Ferleyko, D. Fournier, B. Fox, M.-C. Grenier, W. Gulliver, K. Haveman, C. Hines, K. Hines, A.M. Jackson, C. Jean, G. Jethoo, R. Kahlon, S. Kelly, R. Kim, V. Korley, J. Kornder, L. Kwan, J. Largy, C. Lewis, S. Lewis, I. Mangat, R. Moor, J. Navratil, I. Neas, J. Otis, R. Otis, M. Pandey, F. Petrie, A. Pinter, M. Raines, P. Roberts, M. Robinson, G. Sas, S. Schulman, L. Snell, S. Spearson, J. Stevenson, T. Trahey, S. Wong, D. Wright, H. Ragy, A. Abd El-Aziz, S.K. Abou Seif, M.G. El Din, S. El Etriby, A. Elbahry, A. El-Etreby, M. Elkhadem, A. Katta, T. Khairy, A. Mowafy, M. Nawar, A. Ohanissian, A. Reda, M. Reda, H. Salem, N. Sami, S. Samir, M. Setiha, M. Sobhy, A. Soliman, N. Taha, M. Tawfik, E. Zaatout, D. Kettles, J. Bayat, H. Siebert, A. Horak, Y. Kelfkens, R. Garda, T. Pillay, M. Guerra, L. van Zyl, H. Theron, A. Murray, R. Louw, D. Greyling, P. Mntla, V. Ueckermann, R. Loghdey, S. Ismail, F. Ahmed, J. Engelbrecht, A. Ramdass, S. Maharajh, W. Oosthuysen, G. Angel, C. Bester, M. Booysen, C. Boshoff, C. Cannon, S. Cassimjee, C. Chami, G. Conway, A. Davids, L. de Meyer, G. Du Plessis, T. Ellis, L. Henley, M. Karsten, E. Loyd, J. Marks, L. Mavhusa, M. Mostert, A. Page, L. Rikhotso, M. Salie, J. Sasto, F. Shaik, A. Skein, L. Smith, G. Tarr, T. Tau, F. van Zyl, W. Al Mahmeed, G. Yousef, A. Agrawal, M. Nathani, M. Ibrahim, E.M. Esheiba, R. Singh, A. Naguib, M. Abu-Mahfouz, M. Al Omairi, A. Al Naeemi, R. Maruthanayagam, N. Bazargani, A. Wassef, R. Gupta, M. Khan, B. Subbaraman, A. Abdul, A. Al Mulla, S. El Bardisy, P. Haridas, S. Jadhav, K. Magdaluyo, M. Makdad, I. Maqsood, R. Mohamed, N. Sharma, R. Sharma, M. Thanzeel, S.Z. Goldhaber, R. Canosa, P. Rama, E. Blumberg, J. Garcia, P. Mullen, V. Wilson, A. Quick, K. Ferrick, W.M. Kutayli, M. Cox, M. Franco, S. Falkowski, R. Mendelson, M. Williams, S. Miller, S. Beach, A. Alfieri, T. Gutowski, I. Haque, R. Reddy, W. Ahmed, P. Delafontaine, D. Diercks, D. Theodoro, K. Remmel, M. Alberts, R. Ison, H. Noveck, P. Duffy, S. Pitta, D. Nishijima, C. Treasure, N. Asafu-Adjaye, K. Ball, M. Bartlett, M. Bentley, S. Bowers, A. Brown, A. Browne, J. Cameron-Watts, M. Canova, D. Cassidy, K. Cervellione, S. Congal, J. DePauw, A. Dickerson, M. Eley, L. Evans, S. Felpel, K. Ferdinand, D. Fielder, P. Gentry, A. Haideri, F. Hakimi, T. Harbour, E. Hartranft, B. Hawkins, M. Headlee, L. Henson, C. Herrick, T. Hicks, S. Jasinski, A. Jones, L. Jones, P. Jones, S. Karl, M. Keeling, J. Kerr, P. Knowles, J. Langdon, M. Lay, J.A. Lee, T. Lincoln, E. Malone, A. Merliss, D. Merritt, J. Minardo, B. Mooso, C. Orosco, V. Palumbo, M. Parker, T. Parrott, S. Paserchia, G. Pearl, J. Peterson, N. Pickelsimer, T. Purcell, J. Raynor, S. Raziano, C. Richard, T. Richardson, C. Robertson, A. Sage, T. Sanghera, P. Shaw, J. Shoemaker, K. Smith, B. Stephanie, A. Thatcher, H. Theobald, N. Thompson, L. Treasure, T. Tripti, C. Verdi, and V. Worthy

Subjects
Surgery, RD1-811, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background: The Global Anticoagulant Registry in the FIELD–Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. Methods and results: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012–2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P

Published
2018
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6. On-chip dynamic time reversal of light in a coupled-cavity system

Author

R. Konoike, T. Asano, and S. Noda

Subjects
Applied optics. Photonics, TA1501-1820
Abstract

We theoretically and experimentally demonstrate dynamic, all-linear time-reversal of infrared light in planar optical circuits for the first time. We propose that the oscillatory motion of the light stored in cavities can be time-reversed by fast nonadiabatic tuning of the frequency of eigenmodes of a coupled cavity system and experimentally demonstrate it using a system consisting of distant high-Q-factor two-dimensional photonic crystal cavities between which effective direct couplings are formed via line-defect waveguides. We also analyze the loss and methods to reduce the loss, as well as a theory that expands our system to realize general time-reversal operation for any input light.

Published
2019
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7. Randomly distributed unit sources to enhance optimization in tsunami waveform inversion

Author

I. E. Mulia and T. Asano

Subjects
Environmental technology. Sanitary engineering, TD1-1066, Geography. Anthropology. Recreation, Environmental sciences, GE1-350, Geology, QE1-996.5
Abstract

In tsunami waveform inversion using the conventional Green's function technique, an optimal solution is sometimes difficult to obtain because of various factors. This study proposes a new method to both optimize the determination of the unknown parameters and introduce a global optimization method for tsunami waveform inversion. We utilize a genetic algorithm that further enhanced by a pattern search method to find an optimal distribution of unit source locations prior to the inversion. Unlike the conventional method that characterized by equidistant unit sources, our method generates a random spatial distribution of unit sources inside the inverse region. This leads to a better approximation of the initial profile of a tsunami. The method has been tested using an artificial tsunami source with real bathymetry data. Comparison results demonstrate that the proposed method has considerably outperformed the conventional one in terms of model accuracy.

Published
2015
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8. P466 Real-world effectiveness and safety of golimumab in patients with ulcerative colitis: 52-weeks of post-marketing surveillance data in Japan

Author

S Nakamura, T Asano, Y Tanaka, K Sugimoto, S Yoshigoe, and Y Suzuki

Subjects
Gastroenterology, General Medicine
Abstract

Background Golimumab (GLM) is an anti-TNF-α drug approved for treating ulcerative colitis (UC). Although its efficacy and safety were well established in clinical trials, real-world evidence was still limited. In the present study, we evaluated 52-week effectiveness and safety of GLM treatment for UC based on post-marketing surveillance data. Methods The prospective, post-marketing study was conducted in 393 patients from 163 medical facilities. Patients who had been prescribed GLM were enrolled between May 2017 and September 2019 in Japan. In accordance with Japanese indication, patients received subcutaneous injections of GLM, 200 mg at week 0, 100 mg at weeks 2 and 6, followed by 100 mg every 4 weeks. Clinical remission (partial Mayo score ≤2), predictors of remission, adverse drug reactions (ADRs), and predictors of ADR development were determined at week 52. Results Of 393 enrolled patients, 391 and 386 were included in safety and efficacy analysis set, respectively (Table 1). Overall, clinical remission in the intention-to-treat population was 13.0%, 53.9%, 52.6%, 48.2%, and 43.3% at baseline (BL) and at week 6, 22, 36, and 52, respectively (Table 2). In biologic naïve group, clinical remission was 9.2%, 59.1%, 61.0%, 52.4%, and 47.0% at BL and week 6, 22, 36, and 52, respectively, while in biologic experienced group, it was 15.8%, 50.0%, 46.4%, 45.0%, and 40.5% at BL and week 6, 22, 36, and 52, respectively. At week 52, clinical remission rate in the patients who concomitantly used corticosteroid (CS) at BL was significantly lower than that in the patients who did not receive CS (p=0.017, 37.3% vs 49.2%) (Fig. 1). No significant difference in remission rate was observed between immunomodulator (IM) users and IM non-users at baseline. From multivariate analysis, concomitant use of CS (p=0.001, odds ratio [OR] =0.488, 95% CI [confidence interval] 0.314–0.759) and partial Mayo remission at BL (p Conclusion From the Japanese post-marketing data, the real-world effectiveness of GLM treatment was confirmed in both biologic naïve and experienced populations. Safety profile was generally consistent with previous findings, and no additional safety signals were identified. Concomitant use of CS, but not IM, may be likely to affect outcome of GLM therapy.

Published
2022
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11. Inhibition of novel lipoprotein(a) receptor major facilitator superfamily domain containing 5 (MFSD5) reduces development of aortic valve calcification

Author

F Bartoli-Leonard, M Rogers, K Zheng, A Small, T Asano, S Kuraoka, M Blaser, P Natarajan, C Yeang, S Tsimikas, C O'donnell, M Aikawa, S Singh, E Stroes, and E Aikawa

Subjects
Physiology, Physiology (medical), Cardiology and Cardiovascular Medicine
Abstract

Funding Acknowledgements Type of funding sources: Other. Main funding source(s): Private grant from Kowa Pharmaceuticals to Brigham and Woman's Hospital Calcific aortic valve stenosis (CAVS) is the most prevent valvular heart disease in the western world increasing exponentially with age, with an 112% increase in CAVS deaths in the last three decades; however no therapeutic treatment is currently available. Recently, lipoprotein(a) [Lp(a)] has been demonstrated to be an independent and causal risk factor for CAVS, yet the understanding of its cellular uptake and catabolism is limited thus underscoring the need for further investigation. This study aimed to determine a target receptor, unique for Lp(a) on the surface of valvular interstitial cells (VICs) and ascertain the role of the receptor on the development of VIC calcification. Unbiased ligand-receptor capture mass spectrometry (TriCEPS) was used to identify target receptor, with western blotting, ELISA, qPCR, alizarin red calcium staining and immunofluorescence used to validate the targets in vitro via siRNA inhibition and overexpression. Transmission electron microscopy (TEM) was used to determine uptake of Lp(a) within excised human valves. Identification of small molecule inhibitors was assessed computationally via the L1000 dataset, with the top hit candidate validated in vitro. Genotype-phenotype studies were examined using the United Kingdom Biobank (UKBB) and the Millions Veterans Program. Linear regression was used to evaluate association between aortic stenosis and plasma Lp(a) levels, and a phenotype-wide association analysis was then performed against this generated ‘genotype’. Ligand-receptor capture mass spectrometry was used to detect novel membrane proteins with specific binding to Lp(a); MFSD5, MRC2, LDLR were identified as possible candidates. MFSD5 RNAscope demonstrated its presence in human aortic valves. Lp(a) uptake in VICs was confirmed via western blot and TEM. MFSD5 siRNA significantly reduced dil-labelled Lp(a) uptake in human VICs (p=0.003) and HEPG2 cells (p=0.0003), conversely MFSD5 overexpression increased uptake (p=0.0345, p=0.0318), whilst specificity of MFSD5 to Lp(a) alone was shown via no change in LDL uptake following MFSD5 inhibition (p=0.616, p=0.991). MFSD5 inhibition reduced RUNX2 (p=0.0124) and Osteocalcin (p The current study demonstrates the novel Lp(a) receptor MFSD5 may be responsible for uptake of Lp(a) within VICs, resulting in the development of aortic valve calcification, highlighting the need for further exploration into the role of MFSD5 in aortic valve disease.

Published
2022
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13. Radiation doses of workers engaged in decontamination of the environment

Author

T. Ueno, T. Asano, A. Ito, T. Ogawa, and A. Suzuki

Subjects
Radiological and Ultrasound Technology, Waste management, Public Health, Environmental and Occupational Health, Radioactive waste, Human decontamination, Contamination, Radiation Dosage, law.invention, Atmosphere, Fukushima daiichi, Radiation Protection, Japan, law, Radiation Monitoring, Nuclear Power Plants, Nuclear power plant, Environmental science, Fukushima Nuclear Accident, Humans, Radiology, Nuclear Medicine and imaging, Decontamination
Abstract

After the accident at Fukushima Daiichi nuclear power plant on 11 March 2011, radioactive materials were released into the atmosphere resulting in environmental contamination. Following the implementation of environmental decontamination efforts, the Radiation Dose Registration Centre of the Radiation Effects Association established the radiation dose registration system for decontamination and related workers to consolidate and prevent the loss of radiation records. This article presents statistics on the radiation doses of decontamination and related workers using official records. Since approximately 10 years have passed since the accident in Fukushima, the types of work conducted in the affected restricted areas have changed over time. Therefore, changes in radiation dose for each type of work and comparisons with nuclear workers are presented.

Published
2021

15. Ritonavir, a potent inhibitor of CYP3A4, enhances the anticancer effects of panobinostat in bladder cancer cells

Author

T. Asano, Akinori Sato, and K. Okubo

Subjects
Bladder cancer, CYP3A4, business.industry, Urology, medicine.disease, lcsh:Diseases of the genitourinary system. Urology, lcsh:RC870-923, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, lcsh:RC254-282, chemistry.chemical_compound, chemistry, Panobinostat, medicine, Cancer research, Ritonavir, business, medicine.drug
Published
2020

16. Weak localization and percolation effects in annealed In2O3-ZnO thin films

Author

B. Shinozaki, S. Ezaki, K. Hidaka, K. Makise, T. Asano, K. Yano, and H. Nakamura

Subjects
Physics, QC1-999
Abstract

We have investigated the temperature T and magnetic field H dependences of the sheet resistance R□ of thin (In2O3)0.975-(ZnO)0.025 films with different resistivities and carrier densities prepared by postannealing in air at various annealing temperatures Ta. Regarding the magnetoconductance Δσ(H) ≡ 1/R□(H) − 1/R□(0) of films with large values of sheet resistance R□, agreement between weak localization theory and the data cannot be obtained for any value of the localization length L in (T)=Dτ in (T), where D and τin are the diffusion constant and inelastic scattering time, respectively. Taking account of the inhomogeneous morphology confirmed by Scanning Electron Microscopy (SEM) observation, we introduced the effective sheet resistance R□eff given by R□eff = α × R□meas., where the strength of reduction factor α is less than unit, α ⩽ 1. Using a suitable value of α(Ta), we successfully fitted the theory to data for Δσeff(H, T), regarding Lin2(T) as a fitting parameter in the region 2.0 K⩽T ⩽ 50 K. It was confirmed that the rate 1/τin(T) is given by the sum of the electron-electron and electron-phonon inelastic scattering rates.

Published
2011
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17. Comparison of Forced Oscillation Technique and Spirometry to Assess Inhaled Corticosteroid and Long-Acting Beta-Agonist Combination Therapy Effects on Respiratory Function in Asthmatic Patients: A Post-Hoc Analysis of Open-Label, Randomized, Cross-Over Trial

Author

M. Ariga, S. Kudo, T. Asano, and H. Ohbayashi

Subjects
Agonist, Spirometry, medicine.diagnostic_test, Combination therapy, medicine.drug_class, business.industry, Crossover study, Forced Oscillation Technique, Anesthesia, Post-hoc analysis, medicine, Corticosteroid, Respiratory function, business
Published
2019
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18. Surface Observation of Laser-treated Carbon Steel and Application of Laser Ccleaning for Corroded Steel Member

Author

Shusen Zhuang, Shigenobu Kainuma, M Haraguchi, Muye Yang, and T Asano

Subjects
Materials science, Carbon steel, Iron oxide, engineering.material, Laser, law.invention, chemistry.chemical_compound, chemistry, Optical microscope, law, Thermal, engineering, Laser power scaling, Irradiation, Composite material, Laser beams
Abstract

A newly developed laser system is adopted in this study as a surface preparation method for corroded steel structures. To investigate the thermal effects of laser beam on steel material, carbon steel plates are treated by two different laser processing parameters. Then the surface condition, heat-affected zone, and iron oxide on laser-treated specimens are evaluated using optical microscope, SEM-EDX, and XRD. Moreover, a severely corroded steel member was used as laser irradiation target to verify the cleaning effects of laser beam. Results show that surface morphologies are varied according to laser processing parameters. Due to thermal effects, iron oxide was formed after laser irradiation, and higher laser power induced deeper heat-affected zone. The application of laser treatment for corroded steel member showing desirable surface cleanliness after laser irradiation. The laser surface treatment could be an alternative surface preparation method for steel structures in the construction field.

Published
2021
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19. A Decision Making System Using Deep Learning For Earthquake Prediction By Means Of Electromagnetic Precursors

Author

S.M. Potirakis, C.Z. Patrikakis, P. Kasnesis, Y. Contoyiannis, N.-A. Tatlas, S.A. Mitilineos, T. Asano, and M. Hayakawa

Abstract

The paper “A decision making system using Deep Learning for earthquake prediction by means of electromagnetic precursors”’ was submitted at the EMSEV 2018 International Workshop (Electro-Magnetic Studies of Earthquakes and Volcanoes-“Integrating Geophysical Observations from Ground to Space for Earthquake and Volcano Investigations”), it was accepted, it was presented and included in the conference proceedings

Published
2018
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22. Effects of the Fission Fragments on the Angular Distribution of Scission Particles

Author

Takahiro Wada, N. Carjan, and T. Asano

Subjects
Physics, Cluster decay, Field (physics), Fission, time-dependent Schrödinger equation, Nuclear Theory, scission neutron, Physics and Astronomy(all), nuclear fission, Nuclear fission, scission proton, Yield (chemistry), Coulomb, Particle, Neutron, angular distribution, Atomic physics, Nuclear Experiment
Abstract

We investigate the angular distribution of scission particles taking account of the effects of fission fragments. The time evolution of the wave function of the scission particle is obtained by integrating the time-dependent Schrodinger equation. The effects of the fission fragments are taken into account by means of the optical potentials. The angular distribution is strongly modified by the presence of the fragments. The attractive nuclear potential enhances the yield along the fragment axis for both neutrons and protons. For scission protons, the focusing effect due to the repulsive Coulomb field of the fragments is demonstrated. In the case of asymmetric fission, it is found that the heavy fragment has stronger effects.

Published
2015
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25. P2398Coronary calcification as a mechanism of plaque media shrinkage a multimodality intracoronary imaging study

Author

Y. Zeng, R. Cavalcante, C. Collet, E. Tenekecioglu, Y. Sotomi, Y. Miyazaki, Y. Katagiri, T. Asano, M. Abdelghani, S.P. Nie, C.V. Bourantas, N. Bruining, Y.O. Onuma, and P.W. Serruys

Subjects
medicine.medical_specialty, business.industry, Mechanism (biology), medicine, Imaging study, Medical physics, Radiology, Cardiology and Cardiovascular Medicine, medicine.disease, business, Calcification, Shrinkage
Published
2017
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27. Evaluation of Insulin Independence Using 11C-Methionine Positron Emission Tomography After Living-donor and Brain-dead Donor Pancreas Transplantation

Author

Kenichi Saigo, Taihei Ito, Michihiro Maruyama, Hiromichi Aoyama, I. Matsumoto, K. Otsuki, Y. Uchino, Kyosan Yoshikawa, Naotake Akutsu, T. Kenmoshi, M. Hasegawa, and T. Asano

Subjects
Adult, Male, Brain Death, medicine.medical_specialty, medicine.medical_treatment, Urology, Standardized uptake value, Pancreas transplantation, chemistry.chemical_compound, Methionine, Diabetes mellitus, Living Donors, medicine, Humans, Carbon Radioisotopes, Pancreas, Glycated Hemoglobin, Transplantation, C-Peptide, medicine.diagnostic_test, C-peptide, business.industry, medicine.disease, Surgery, Diabetes Mellitus, Type 1, surgical procedures, operative, medicine.anatomical_structure, chemistry, Positron emission tomography, Positron-Emission Tomography, Pancreatitis, Female, Pancreas Transplantation, Radiopharmaceuticals, Tomography, X-Ray Computed, business
Abstract

We recently reported that 11 C-methionine positron-emission tomography (PET) is clinically useful for the evaluation of the pancreatic function of the living donor. The objective of this study was to evaluate the postoperative insulin independence in 10 living donor (LD) and 10 brain-dead donor (BD) pancreas transplantations for 20 patients with type I diabetes mellitus by using 11 C-methionine PET. After 6 months, PET/computed tomography was performed 30 minutes after 11 C-methionine (370–740 MBq) injection. The uptake in the pancreas was expressed as the standardized uptake value (SUV). Patient survival rates were 100% at 5 years for LD transplantations and at 2 years for BD transplantations. Insulin independence was 60% for LD transplantations at 5 years and 75% for BD transplantations at 2 years. There were no major surgical complications such as vascular thrombosis, intra-abdominal abscess, and graft pancreatitis. The SUVs for LD and BD pancreas transplantations with insulin independence were 7.2 ± 1.8 and 10.4 ± 2.3, respectively. The SUVs for LD pancreas transplantations with insulin dependence and BD pancreas transplantations with graft failure were 3.6 ± 1.1 and 2.9 ± 1.0, respectively. At 5 years after transplantation, for the LD transplants, the insulin-independent rate was 100% for the graft recipients with an SUV higher than 5, and the median insulin independence duration of the graft recipients with an SUV less than 5 was 7 months ( P 11 C-methionine PET may be a potent modality to predict long-term insulin independence and the avoidance of pancreas graft failure.

Published
2014
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28. Clinical nephrology - miscellaneous

Author

C. Bantis, P. Heering, N.-M. Kouri, M. Siekierka-Harreis, M. Stangou, C. Schwandt, G. Efstratiadis, L.-C. Rump, K. Ivens, I. Haddiya, T. Houssaini Squalli, I. Laouad, B. Ramdani, R. Bayahia, G. G. Dimas, T. J. Tegos, S. G. Spiroglou, C. G. Pitsalidis, A. S. Sioulis, I. M. Karamouzis, C. G. Savopoulos, M. I. Karamouzis, A. G. Orologas, A. I. Hatzitolios, D. M. Grekas, D. Maixnerova, E. Jancova, I. Rychlik, R. Rysava, M. Merta, J. Reiterova, A. Kolsky, E. Honsova, J. Skibova, V. Tesar, Z. Kendi Celebi, R. Calayoglu, K. Keven, I. Kurultak, P. Mescigil, B. Erbay, O. Karatan, N. Duman, S. Erturk, G. Nergizoglu, S. Kutlay, S. Sengul, K. Ates, F. Marino, C. Martorano, M. Bellantoni, R. Tripepi, C. Zoccali, K. Ishizuka, Y. Harita, Y. Kajiho, H. Tsurumi, T. Asano, K. Nishiyama, N. Sugawara, H. Chikamoto, Y. Akioka, Y. Yamaguchi, T. Igarashi, M. Hattori, P. J. Heering, M. Sahay, D. V. Monova, S. V. Monov, Y.-y. Wang, H. Cheng, G.-q. Wang, H.-r. Dong, Y.-p. Chen, C.-j. Wang, Y.-l. Tang, E. Buti, E. Dervishi, F. Bergesio, G. Ghiandai, A. Mjeshtri, N. Paudice, A. L. Caldini, C. Nozzoli, E. E. Minetti, L. Sun, J. Feng, L. Yao, Q. Fan, J. Ma, L. Wang, T. Kirsanova, L. Merkusheva, N. Ruinihina, N. Kozlovskaya, G. Elenshleger, K. Turgutalp, U. Karabulut, T. Ozcan, I. Helvaci, A. Kiykim, A. Kaul, D. Bhadhuaria, R. sharma, N. Prasad, A. Gupta, C. Clajus, J. Schmidt, H. Haller, P. Kumpers, S. David, A. M. Sevillano, M. Molina, E. Gutierrez, E. Morales, E. Gonzalez, E. Hernandez, M. Praga, J. L. Conde Olasagasti, C. Vozmediano Poyatos, M. L. Illescas, S. Tallon, J. J. Uson Carrasco, A. Roca Munoz, F. Rivera Hernandez, G. Ismail, R. Jurubita, A. Andronesi, R. Bobeica, D. Zilisteanu, E. Rusu, C. Achim, A. Huerta, J. Caro, E. Gutierrez-Solis, A. Pasquariello, G. Pasquariello, M. Innocenti, G. Grassi, M. F. Egidi, O. Ozturk, A. Yildiz, C. B. Gul, K. Dilek, L. Tylicki, A. Jakubowska, E. Weber, S. Lizakowski, D. Swietlik, B. Rutkowski, A. Postorino, S. Costa, S. Cristadoro, G. Magazzu, G. Bellinghieri, V. Savica, M. Buemi, D. Santoro, Y. Lu, P. Shen, X. Li, Y. Xu, X. Pan, W. Wang, X. Chen, W. Zhang, H. Ren, N. Chen, B. P. Mitic, T. Cvetkovic, P. Vlahovic, R. Velickovic Radovanovic, V. Stefanovic, S. Kostic, V. Djordjevic, Q. Ao, Q. Ma, Q. Cheng, X. Wang, S. Liu, R. Zhang, S. Ozturk, S. Ozmen, D. Akin, R. Danis, M. Yilmaz, S. Hajri, S. Barbouche, H. Okpa, E. Oviasu, L. Ojogwu, N. Fotouhi, A. Ghaffari, F. Hamzavi, H. Nasri, M. Ardalan, A. Stott, A. Ullah, H. Anijeet, S. Ahmed, H. S. Kohli, R. Rajachandran, M. Rathi, V. Jha, V. Sakhuja, E. Yenigun, F. Dede, D. Turgut, E. Koc, H. Akoglu, S. Piskinpasa, R. Ozturk, A. Odabas, D. Bajcsi, G. Abraham, E. Kemeny, S. Sonkodi, P. Legrady, A. Letoha, K. Constantinou, Z. Ondrik, B. Ivanyi, G. Lucisano, N. Comi, P. Cianfrone, C. Summaria, V. Piraina, R. Talarico, C. Camastra, G. Fuiano, I. Proletov, E. Saganova, O. Galkina, E. Bogdanova, I. Zubina, V. Sipovskii, A. Smirnov, E. Bailly, D. Pierre, R. Kerdraon, O. Grezard, E. Gnappi, M. Delsante, M. Galetti, U. Maggiore, L. Manenti, M. J. Hasan, M. A. Muqueet, M. Mostafi, I. Chowdhury, W. Haque, T. Khan, Y.-J. Kang, E. J. Bae, H. S. Cho, S.-H. Chang, D. J. Park, G. Xu, H. Lin, Z. Hu, X. Yu, C. Xing, C. Mei, L. Zuo, Z. Ni, X. Ding, D. Li, Q. Zhang, X. Feng, and L. Lin

Subjects
Transplantation, medicine.medical_specialty, Nephrology, business.industry, medicine, Clinical nephrology, Intensive care medicine, business
Published
2013
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29. Effects of Fission Fragments on the Angular Distribution of Scission Neutrons

Author

M. Rizea, N. Carjan, M. Hirokane, T. Asano, and Takahiro Wada

Subjects
Physics, time-dependent Schrödinger equation, Cold fission, Scattering, Fission, Neutron emission, Nuclear Theory, Time evolution, Physics and Astronomy(all), scission neutron, Schrödinger equation, nuclear fission, symbols.namesake, neutron emission, Nuclear fission, symbols, angular distribution, Neutron, Atomic physics, Nuclear Experiment
Abstract

We investigate the effects of the fission fragments on the angular distribution of scission neutrons. The time evolution of the wave function of the scission neutron is obtained by integrating the time-dependent Schrodinger equation. The effects of the re-absorption and scattering by the fission fragments are taken into account by means of the optical potential. The angular distribution is strongly modified by the presence of the fragments. Dependence on the magnitude of the absorption is discussed. Influence of the finiteness of the grid size is also discussed.

Published
2013
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31. Localized and mixed valence state of Ce4fin superconducting and ferromagneticCeO1−xFxBiS2revealed by x-ray absorption and photoemission spectroscopy

Author

Eugenio Paris, Eike F. Schwier, Tatsuma D. Matsuda, Antonella Iadecola, Takashi Mizokawa, T. Asano, Y. Aoki, Naurang L. Saini, Daiki Ootsuki, Kenya Shimada, Hideaki Iwasawa, T. Sugimoto, Ryuji Higashinaka, and M. Salome

Subjects
Superconductivity, X-ray absorption spectroscopy, Materials science, Valence (chemistry), Absorption spectroscopy, Condensed matter physics, Photoemission spectroscopy, Fermi level, Doping, 02 engineering and technology, 021001 nanoscience & nanotechnology, 01 natural sciences, Spectral line, Crystallography, symbols.namesake, 0103 physical sciences, symbols, 010306 general physics, 0210 nano-technology
Abstract

We have performed Ce ${L}_{3}$-edge x-ray absorption spectroscopy (XAS) and Ce $4d\ensuremath{-}4f$ resonant photoemission spectroscopy (PES) on single crystals of ${\mathrm{CeO}}_{1\ensuremath{-}x}{\mathrm{F}}_{x}{\mathrm{BiS}}_{2}$ for $x=0.0$ and 0.5 in order to investigate the Ce $4f$ electronic states. In Ce ${L}_{3}$-edge XAS, a mixed valence of Ce was found in the $x=0.0$ sample, and F doping suppressed it, which is consistent with the results on polycrystalline samples. As for resonant PES, we found that the Ce $4f$ electrons in both $x=0.0$ and 0.5 systems respectively formed a flat band at 1.0 and 1.4 eV below the Fermi level and there was no contribution to the Fermi surfaces. Interestingly, Ce valence in ${\mathrm{CeOBiS}}_{2}$ deviates from ${\mathrm{Ce}}^{3+}$ even though Ce $4f$ electrons are localized, indicating the Ce valence is not in a typical valence fluctuation regime. We assume that localized Ce $4f$ in ${\mathrm{CeOBiS}}_{2}$ is mixed with unoccupied Bi $6{p}_{z}$, which is consistent with a previous local structural study. Based on the analysis of the Ce ${L}_{3}$-edge XAS spectra using Anderson's impurity model calculation, we found that the transfer integral becomes smaller, increasing the number of Ce $4f$ electrons upon the F substitution for O.

Published
2016
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35. Regional distribution of lymph node metastasis in upper urinary tract urothelial cancer, sub-analysis of large multi-institutional study (JCOG1110A)

Author

Atsushi Takenaka, Osamu Ogawa, T. Asano, Tatsuo Tochigi, Junki Mizusawa, Tomomi Kamba, T. Tanikawa, Junichi Inokuchi, Nobuo Shinohara, Tomohiko Ichikawa, Mikio Sugimoto, M. Niwakawa, A. Yamaguchi, Momokazu Gotoh, Seiji Naito, Hiroyuki Nishiyama, Hiroyuki Fujimoto, Shin Egawa, Tomonori Habuchi, Masatoshi Eto, Kentaro Kuroiwa, Kiyohide Fujimoto, Yoshiki Sugimura, Hideaki Miyake, K. Hashine, Naoya Masumori, Chikara Ohyama, T. Kojima, T. Nakagawa, K. Nishimura, Osamu Ishizuka, Norihiko Tsuchiya, Yoshiyuki Kakehi, K. Miyamoto, Hideyasu Matsuyama, and Y. Arai

Subjects
Pathology, medicine.medical_specialty, business.industry, Urology, Medicine, Urothelial cancer, Distribution (pharmacology), Lymph node metastasis, business, Upper urinary tract
Published
2018
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37. Characterization of ${\rm Bi}_{2}{\rm Sr}_{2}{\rm CaCu}_{2}{\rm O}_{8+\delta}$ Stacks Fabricated by Acid Treatment Process

Author

Katsuyoshi Hamasaki, S. Sunaga, Kanji Yasui, T Asano, Hisashi Shimakage, H Mizumaru, J. Chen, and Takahiro Kato

Subjects
Josephson effect, Materials science, High-temperature superconductivity, Stacking, Analytical chemistry, Temperature cycling, Substrate (electronics), Condensed Matter Physics, Electronic, Optical and Magnetic Materials, law.invention, Crystal, law, Electrical and Electronic Engineering, Single crystal, Microwave
Abstract

Bi2Sr2CaCu2O8+δ (Bi-2212) stacks of intrinsic Josephson junctions were fabricated by an acid-treatment process from inside a single crystal. The surrounding acid-treated product is a transparent material, BiOCl. During the process, an optical adhesive (NOA-61) was used to fix a piece of the crystal on a glass substrate and to coat the surface of the sample. The current-voltage characteristics of the stacks at T = 77 K exhibited large hystereses and multiple branches with voltage spacings of approximately 2-3 mV. Under an external microwave field in the frequency range of 2-18 GHz, clear Shapiro steps were observed at voltages with multiples of (h/2e)frf. In addition, the thermal cycling properties of the critical current (Ic) were investigated. No apparent degradation of the Ic was observed during repeated thermal cycling between 300 and 77 K.

Published
2011
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38. Design Consideration and Demonstration of Resonant-Cavity-Enhanced Quantum Dot Infrared Photodetectors in Mid-Infrared Wavelength Regime (3–5 $\mu{\rm m}$)

Author

Anupam Madhukar, Chong Hu, Yi Zhang, Joe C. Campbell, Mingguo Liu, and T Asano

Subjects
Physics, business.industry, Photoconductivity, Superlattice, Photodetector, Optical field, Condensed Matter::Mesoscopic Systems and Quantum Hall Effect, Condensed Matter Physics, Laser, Atomic and Molecular Physics, and Optics, law.invention, Gallium arsenide, chemistry.chemical_compound, Optics, chemistry, law, Quantum dot, Optoelectronics, Electrical and Electronic Engineering, business, Optical path length
Abstract

Lattice-mismatched-strain-driven, defect-free, 3-D islands, dubbed self-assembled quantum dots (SAQDs), currently provide the most advanced platform for quantum-dot-based devices with successful applications to SAQD lasers and considerable potential for infrared detectors. For the latter, one of the limitations is the short optical path length owing to the difficulties in creation of large numbers of quantum dot layers without formation of structural defects arising from accumulated strain. This limitation can be considerably overcome by creation of an appropriate resonant cavity to enhance the optical field in the SAQD regions. In this paper, we demonstrate resonant-cavity-enhanced quantum dot infrared photodetectors in the mid-infrared (MIR, 3-5 μm ) regime. For effective enhancement, the SAQDs are designed to generate a very narrow peak (Δλ/λ ~ 10%) in the intraband photocurrent response in the MIR range utilizing short period superlattices as the quantum confining layers. Incorporating such SAQD layers at specific enhanced electric field regions within the resonant cavity comprising a two-pair GaAs/air-gap back mirror and a GaAs surface front mirror, we have obtained QDIP detectivity enhancement of ~ 8-12 times.

Published
2010
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39. Fluxgate DC Earth Leakage Current Sensor

Author

S. Kuribara, K. Toyama, T. Asano, and T. Kudo

Subjects
Materials science, business.industry, Busbar, Electrical engineering, Condensed Matter Physics, Fluxgate compass, Electronic circuit simulation, Electronic, Optical and Magnetic Materials, Magnetic field, Current sensor, Electrical and Electronic Engineering, Current (fluid), business, Fiber optic current sensor, Instrumentation, Voltage
Abstract

This paper describes results obtained from analysis and experiments done on a fluxgate dc earth leakage current sensor for electric vehicles and photovoltaic power generation systems. As fluxgate current sensors are extremely sensitive to room temperature, various applications need this characteristic. However, conventional fluxgate current sensors have a problem in that they can only measure a narrow range of currents. To address this issue, we propose that the turns of the excitation coil be optimized with a simulator. This new sensor consists of a coiled wire that is wound around a toroidal amorphous core and through a bus bar. The sensor detects variations in excitation current according to dc current. The sensor was analyzed with a simulator. The magnetic field simulator was used to calculate the excitation current, and the output voltage according to the excitation current was calculated with a circuit simulator. We found that the results from simulations almost corresponded to those from measurements, and were able to verify the validity of the basic analytical model. As a result of analysis with the simulator, 35 turns of the excitation coil were used to achieve a wide range of measurements of ±600 mA.

Published
2010
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41. Experimental and Numerical Analysis of Strain in High-Strength $\hbox{Nb}_{3}\hbox{Sn}$ Magnets

Author

T. Asano, Mitsuho Furuse, T. Iwamura, S. Minowa, Tomoaki Takao, Masaichi Umeda, and H. Sato

Subjects
Materials science, Condensed matter physics, Stress–strain curve, Stress–strain analysis, Young's modulus, Superconducting magnet, Condensed Matter::Mesoscopic Systems and Quantum Hall Effect, Condensed Matter Physics, Electronic, Optical and Magnetic Materials, Conductor, Stress (mechanics), symbols.namesake, Magnet, symbols, Electrical and Electronic Engineering, Electrical conductor
Abstract

We have developed a high-strength Ta-reinforced conductor for high-magnetic-field magnets. In our previous work, it was demonstrated that the Ta-reinforced conductor had good characteristics against mechanical stress and strain. In this study, we made a 2-D calculation code for a stress-strain analysis, and derived the stress and strain of the magnet using some physical values such as the Young's modulus of the conductors, magnet dimensions and so on. According to the calculation results of some model magnets, the Ta-reinforced conductor could be used without extra support structures. Hence, the conductors are fit for high-magnetic-field and large-scale magnets such as NMR and SMES magnets.

Published
2008
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42. Influence of Bending and Torsion Strains on Critical Currents in YBCO Coated Conductors

Author

H. Sato, S. Minowa, Y. Shiohara, Tomoaki Takao, J. Kato, T. Asano, T. Iwamura, Atsushi Ishiyama, K. Nakao, Takato Machi, and Y. Fukasawa

Subjects
Superconductivity, Materials science, High-temperature superconductivity, chemistry.chemical_element, Torsion (mechanics), Yttrium barium copper oxide, Condensed Matter Physics, Electronic, Optical and Magnetic Materials, Bismuth, law.invention, Conductor, chemistry.chemical_compound, Compressive strength, chemistry, law, Electrical and Electronic Engineering, Composite material, Electrical conductor
Abstract

A YBCO coated conductor is expected to be a next generation high performance superconductor. To design superconducting machines using YBCO conductors, evaluation of not only superconducting properties but also mechanical properties is very important. Hence, we applied bending and torsion to the YBCO conductor and measured degradation of the conductor against the strain. To compare with the YBCO's data, a Bi2223 conductor was also tested under the same experimental condition. From the bending test, degradation of the Bi conductor was faster than that of the YBCO conductor and the critical current gradually decreased with increasing bending strain. The YBCO conductor kept better performance than the Bi conductor, and degradation suddenly occurred. And when the superconducting layer in the YBCO conductor was subjected to compressive strain in the bending test, the critical current hardly decreased at approximately one percent of the bending strain.

Published
2007
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43. Immediate maxillary reconstruction after malignant tumor extirpation

Author

Yoshihiro Kimata, R. Hayashi, S. Sarukawa, Minoru Sakuraba, T. Asano, S. Ebihara, and T. Yano

Subjects
Male, Maxillary reconstruction, medicine.medical_specialty, Reconstructive surgery, Malignancy, Surgical Flaps, Resection, Postoperative Complications, Humans, Medicine, Aged, Maxillary Neoplasms, business.industry, Cartilage, General Medicine, Plastic Surgery Procedures, medicine.disease, Surgery, Treatment Outcome, medicine.anatomical_structure, Oncology, Vascularized bone, Maxilla, Female, business, Algorithms
Abstract

Aims Immediate maxillary reconstruction after malignant tumor extirpation differs from other types of maxillary reconstruction. Our reconstruction algorithm is described in this article. Methods One hundred ninety-four patients who had undergone maxillectomy for malignant tumors were reviewed, and maxillectomy defects were classified with the method of Cordeiro and Santamaria. Results Mean total blood loss was 848 ml, and 71 patients died within 2 years after surgery. For type IIIa defects of the orbital floor, titanium mesh or vascularized bone or cartilage was used for reconstruction, but the rate of postoperative complications did not differ between titanium and autografts. Therefore, to reconstruct orbital floor defects we have recently used only titanium mesh. For type I or II defects, we use autografts for only selected cases. Conclusions We strive to perform less-invasive reconstructive surgery after resection for maxillary malignancy.

Published
2007
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44. Induction of CD16+ CD56brightNK Cells with Antitumour Cytotoxicity not only from CD16− CD56brightNK Cells but also from CD16− CD56dimNK Cells

Author

Noritsugu Kuranaga, Shuhji Seki, Yoshiko Habu, T. Asano, K. Satoh, Nariyoshi Shinomiya, Eiji Takahashi, and M. Hayakawa

Subjects
Lymphokine-activated killer cell, genetic structures, Chemistry, Janus kinase 3, Immunology, hemic and immune systems, chemical and pharmacologic phenomena, General Medicine, NKG2D, Molecular biology, CD49b, stomatognathic diseases, Interleukin 21, NK-92, Myeloid-derived Suppressor Cell, Interleukin 12, sense organs
Abstract

The aim of this study was to examine the effect of cytokines on different subsets of NK cells, while especially focusing on CD16(-) CD56(dim) cells and CD16(-) CD56(bright) cells. When human peripheral blood mononuclear cells (PBMC) were cultured with a combination of IL-2, IL-12 and IL-15 for several days, a minor population of CD56(bright) NK cells expanded up to 15%, and also showed potent cytotoxicities against various cancer cells. Sorting experiments revealed that unconventional CD16(-) CD56(+) NK cells (CD16(-) CD56(dim) NK cells and CD16(-) CD56(bright) NK cells, both of which are less than 1% in PBMC) much more vigorously proliferated after cytokine stimulation, whereas predominant CD16(+) CD56(dim) NK cells proliferated poorly. In addition, many of the resting CD16(-) CD56(bright) NK cells developed into CD16(+) CD56(bright) NK cells, and CD16(-) CD56(dim) NK cells developed into CD16(-) CD56(bright) NK cells and also further into CD16(+) CD56(bright) NK cells by the cytokines. CSFE label experiments further substantiated the proliferation capacity of each subset and the developmental process of CD16(+) CD56(bright) NK cells. Both CD16(-) CD56(dim) NK cells and CD16(-) CD56(bright) NK cells produced large amounts of IFN-gamma and Fas-ligands. The CD16(+) CD56(bright) NK cells showed strong cytotoxicities against not only MHC class I (-) but also MHC class I (+) tumours regardless of their expression of CD94/NKG2A presumably because they expressed NKG2D as well as natural cytotoxicity receptors. The proliferation of CD16(+) CD56(bright) NK cells was also induced when PBMC were stimulated with penicillin-treated Streptococcus pyogenes, thus suggesting their role in tumour immunity and bacterial infections.

Published
2007
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46. 1H-NMR studies of quantum spin chain system (CH3)2NH2CuCl3at very low temperature

Author

Y Inagaki, Y. Nishisaka, T Asano, K. Kumagai, and Yoshinori Furukawa

Subjects
History, Field (physics), Chemistry, Chain system, Proton NMR, Physical chemistry, Dilution refrigerator, Quantum spin liquid, Magnetic phase diagram, Computer Science Applications, Education
Abstract

We report 1H NMR results for (CH3)2NH2CuCl3measured at very low temperature down to 0.1 K using a dilution refrigerator. Field induced magnetic ordered state is revealed by the NMR measurements and a magnetic phase diagram for the system is proposed.

Published
2006
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47. Chiral BEDOT-based copolymers prepared by chemical and electrochemical polymerization

Author

Y.S. Jeong, Kazuo Akagi, Hiromasa Goto, T. Asano, and S. Iimura

Subjects
General Physics and Astronomy, Photochemistry, Diethyl azodicarboxylate, chemistry.chemical_compound, Monomer, chemistry, Polymerization, Electrochromism, Polymer chemistry, Copolymer, General Materials Science, Mitsunobu reaction, Triphenylphosphine, Tetrahydrofuran
Abstract

Optically active conjugated copolymers, poly[1,4-bis[2-(3,4-ethylenedioxy)thienyl]-2,5-benzoic acid-1-methylheptyl ester] [poly (BEDOT-B(OCT*)], were synthesized by chemical and electrochemical oxidative polymerizations. Poly[BEDOT-B(OCT*)] of both ( R ) and ( S ) configuration were synthesized by introducing chiral octyloxycarbonyl group in the side chain. The dibromo compounds, ( R )-1 and ( S )-1, were prepared by Mitsunobu reaction by an esterification of ( R ) or ( S )-octanol and 2,5-dibromobenzoic acid with an aid of diethyl azodicarboxylate (DEAD) and triphenylphosphine (TPP) in tetrahydrofuran. The monomers were then prepared with Stille coupling technique using Pd(PPh 3 ) 4 Cl 2 as a catalyst to produce ( R )-1 and ( S )-1. The monomer was electropolymerized onto platinum button and ITO glass electrodes by repeated scanning from −1.0 V to +1.0 V versus Ag/Ag + at 20 mV/s. The polymer was electrochromic and reversibly switching from purple green upon oxidation. The chemical polymerization was also carried out in dimethylformamide with a Ni(cod) 2 catalyst. Optical absorption and circular dichroism (CD) measurements were examined. The polymers showed Cotton effects in CD spectra. This method therefore represents a new technique for the preparation of chiral polymer with helicity, which can disclose a possibility toward “chiralelectrochemistry”.

Published
2006
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48. Mechanical Loss of HTS Coils Reinforced With Negative Thermal Expansion Fiber Materials

Author

H. Sato, Y. Fukasawa, T. Asano, T. Iwamura, Mitsuho Furuse, S. Minowa, Tomoaki Takao, Atsuhiko Yamanaka, and Masaichi Umeda

Subjects
Materials science, Bobbin, Negative thermal expansion, Electromagnetic coil, Cylinder stress, Solenoid, Electrical and Electronic Engineering, Composite material, Liquid nitrogen, Condensed Matter Physics, Thermal expansion, Electronic, Optical and Magnetic Materials, Magnetic field
Abstract

High-Tc superconducting (HTS) coils with various types of reinforcement are investigated with respect to the reduction of mechanical loss. The total AC loss of the coils is measured under an external DC magnetic field at liquid nitrogen temperature, the reduction of the mechanical loss components are estimated. Tensioned stainless-steel tape is found to be the most effective for reducing the mechanical loss by improving the rigidity of the entire winding. The mechanical loss of the HTS coils is reduced by reinforcement with a bobbin of negative thermal expansion material, although the hoop stress caused by radial expansion of the bobbin is absorbed by a small number of winding turns. Bobbins of negative thermal expansion material are therefore unsuitable for pancake-type coils or multilayer windings, but can be expected to realize substantial reductions in mechanical loss for single-layer windings or thin solenoids

Published
2006
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49. CAD System for Detecting Clustered Microcalcifications in Digital Mammograms using Independent Component Analysis and Neural Network

Author

Hiroyasu Yamakawa, Hiromichi Ando, T. Asano, Yoshikazu Uchiyama, Takeshi Hara, Ryujiro Yokoyama, Hiroki Kato, Hiroshi Fujita, Hiroaki Hoshi, Xiangrong Zhou, Toru Iwama, and J. Ogura

Subjects
Scheme (programming language), medicine.medical_specialty, Virtual colonoscopy, Computer science, Biomedical Engineering, Health Informatics, CAD, Aneurysm, medicine, Radiology, Nuclear Medicine and imaging, Computer vision, computer.programming_language, medicine.diagnostic_test, business.industry, Mr angiography, General Medicine, medicine.disease, Computer Graphics and Computer-Aided Design, Computer aided detection, Computer Science Applications, Surgery, Computer Vision and Pattern Recognition, Artificial intelligence, Radiology, business, computer
Published
2006
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50. Loss spectrum and electromagnetic behavior of problem 21 family

Author

N. Takahashi, Hua Yang, L. Gou, Lanrong Liu, Sheng Gao, Xiaopeng Ren, Zhiguang Cheng, Qifan Hu, Sumei Yang, and T. Asano

Subjects
Electromagnetic field, Physics, Spectrum (functional analysis), Shields, Electronic, Optical and Magnetic Materials, law.invention, Magnetic field, Nuclear magnetic resonance, law, Electromagnetic shielding, Eddy current, Electronic engineering, Computational electromagnetics, Electrical and Electronic Engineering, Analysis method
Abstract

A set of both the magnetic and electromagnetic shielding models, referred to as a new member of the Problem 21 family, is proposed to investigate the shielding effects of different kinds of shields. This paper presents the newly measured and calculated results of both the magnetic field and stray-field loss concerning the TEAM-based models to detail the electromagnetic behavior of the Problem 21 family, evaluates the engineering applicability of three-dimensional eddy current analysis methods, and validates the engineering effectiveness of the practical loss modeling proposed by the authors

Published
2006
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