25 results on '"T.A. Luger"'
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2. α-Melanozyten-stimulierendes Hormon
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T.A. Luger and M. Böhm
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Gynecology ,medicine.medical_specialty ,visual_art.visual_artist ,Sunbathing ,business.industry ,visual_art ,Photosensitivity Disorder ,medicine ,Dermatology ,business ,Injections subcutaneous - Abstract
α-Melanozyten-stimulierendes Hormon (α-MSH) ist ein Tridekapeptid, das in der Haut selbst aus dem Prakursor Proopiomelanokortin gebildet wird. Es vermittelt Ultraviolett-Licht-vermittelte Pigmentierung nach Binding an Melanokortin-1-Rezeptoren (MC-1R), die u. a. auf der Oberflache von epidermalen Melanozyten exprimiert sind. Die pigmentinduzierende und zytoprotektive Wirkung von α-MSH bildet das Rationale fur den ersten klinischen Einsatz eines subkutan applizierbaren synthetischen und superpotenten α-MSH-Analogons, Nle4-D-Phe7-α-MSH (NDP-α-MSH), in Phase-II-Studien bei Patienten mit Photodermatosen, z. B. der erythropoietischen Protoporphyrie. Da α-MSH in einer Reihe von praklinischen Untersuchungen neben seiner melanotropen Wirkung auch vielversprechende antiinflammatorische und antifibrotische Effekte gezeigt hat, wird es von grosem Interesse sein, diese Eigenschaften anhand weiterer klinischer Pilotstudien mit NDP-α-MSH zu uberprufen. Neben synthetischen α-MSH-Analoga bieten daruber hinaus Tripeptid-Derivate wie KdPT, die nicht an MC-1R binden, aber erhaltene antiinflammatorische Eigenschaften haben, eine weitere neue therapeutische Strategie in der Dermatologie.
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- 2010
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3. A Study of the Safety and Efficacy of Calcipotriol and Betamethasone Dipropionate Scalp Formulation in the Long-Term Management of Scalp Psoriasis
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P. Kidson, Neil H. Shear, F. Clonier, T.A. Luger, F. Cambazard, G. Gupta, F.G. Larsen, and M. Bourcier
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Adult ,Male ,Canada ,medicine.medical_specialty ,Adolescent ,Denmark ,Anti-Inflammatory Agents ,Betamethasone dipropionate ,Dermatology ,Administration, Cutaneous ,Betamethasone ,Severity of Illness Index ,law.invention ,Ointments ,chemistry.chemical_compound ,Calcitriol ,Double-Blind Method ,Randomized controlled trial ,law ,Germany ,Psoriasis ,Long term management ,medicine ,Humans ,Prospective Studies ,Calcipotriol ,Aged ,Aged, 80 and over ,Scalp ,business.industry ,Pharmacology and Treatment ,Middle Aged ,medicine.disease ,United Kingdom ,Drug Combinations ,Treatment Outcome ,medicine.anatomical_structure ,chemistry ,Female ,Dermatologic Agents ,France ,Pharmaceutical Vehicles ,business ,Scalp psoriasis ,medicine.drug - Abstract
Background: Effective and safe products are needed for long-term management of scalp psoriasis. This study investigated the long-term safety and efficacy of a two-compound formulation (calcipotriol 50 µg/g plus betamethasone dipropionate 0.5 mg/g) for scalp psoriasis. Methods: In this 52-week, international, double-blind study, 869 patients with moderate-to-severe scalp psoriasis were randomized to either a two-compound scalp formulation (n = 429) or calcipotriol (n = 440). Results: Adverse drug reactions were less frequent in the two-compound group compared with the calcipotriol group (17.2 vs. 29.5%; p < 0.001). Incidences of adverse events possibly associated with long-term corticosteroid use were low in both the two-compound (2.6%) and the calcipotriol (3.0%) groups. Disease was satisfactorily controlled in 92.3% of visits in the two-compound group versus 80.0% in the calcipotriol group (p < 0.001). Conclusion: The two-compound scalp formulation demonstrated a high level of safety and efficacy in long-term management of scalp psoriasis.
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- 2008
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4. Mycophenolatmofetil und Leflunomid: viel versprechende Immunmodulatoren zur Therapie von Hauterkrankungen. Mycophenolate mofetil and leflunomide: promising compounds for the treatment of skin diseases
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T.A. Luger and U. Frieling
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business.industry ,Nucleotide Biosynthesis ,Immunology ,Medicine ,Dermatology ,business ,Molecular biology ,Antibody formation - Abstract
Zusammenfassung: Im vergangenen Jahrzehnt gab es erhebliche Fortschritte im Verstandnis fur die Pathomechanismen immunvermittelter Erkrankungen, die zu signifikanten Weiterentwicklungen von immuntherapeutischen Strategien gefuhrt haben. In Folge dessen ist die Anzahl spezifischer sowie unspezifischer immunmodulierender zur Therapie von Hauterkrankungen erheblich erweitert worden. Von den unspezifischen Immunmodulatoren zeigen Mycophenolatmofetil und Leflunomid viel versprechende Wirkungen bei einer Reihe autoimmun und entzundlich bedingter Hauterkrankungen. Beide Substanzen hemmen ein Schlusselenzym der Nukleotid-Biosynthese, ein Schritt, der entscheidend fur die Produktion zytotoxischer T-Zellen und die Antikorperbildung ist. Beide Substanzen haben keinen direkten Einfluss auf die DNS, wodurch moglicherweise ihr gunstiges Nebenwirkungsprofil erklart werden kann. Summary: In the past decade, there has been enormous progress in the understanding of the pathomechanisms of immune-mediated diseases, which has led to major advances in immunotherapeutic strategies. As a consequence, the armamentarjum of specific and nonspeciflc immune-modulating and immunosuppressive drugs for the treatment of skin diseases has been widely extended. Among the nonspeciflc immunomodulators, mycophenolate mofetil and leflunomide show promising effects in a variety of autoimmune and inflammatory skin disorders. Both compounds inhibit a key enzyme in nucleotide biosynthesis, a step that is pivotal for the production of cytotoxic T cells and antibody formation. They do not act in the nucleus, wbich may explaln their advantageous side-effect profile.
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- 2002
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5. Zytokine
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T.A. Luger and D. Nashan
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Gynecology ,medicine.medical_specialty ,Pathology ,Epidermoid carcinoma ,business.industry ,medicine ,Dermatology ,business - Abstract
Verschiedene therapeutischen Optionen in der Behandlung der Melanome, T-Zell-Lymphome, B-Zell-Lymphome, Spinaliome, Basalzellkarzinome und Merkel-Zell-Karzinome beinhalten Zytokine. Zytokintherapien umfassen die Zytokinsubstitution, Zytokininduktion, Zytokintransfektion und therapeutische Zytokinkonstrukte. In der adjuvanten Behandlung des Melanoms etabliert sich zunehmend der Einsatz von IFN-α. Auswertungen randomisierter adjuvanter Studienprotokolle sprechen fur eine statistisch signifikante Verlangerung des rezidivfreien Intervalls. IL-2 hat einen Stellenwert in der Therapie fortgeschrittener Stadien des Melanoms wie auch im Rahmen von Vakzinierungen. Weitere mogliche therapeutische Immunmodulatoren, die experimentell und in Pilotstudien uberpruft werden, sind IL-4, IL-7 und GM-CSF. Eine vielversprechende Behandlungsmoglichkeit beruht auf dem Einsatz von IL-12. In der Behandlung der kutanen T-Zell-Lymphome konnte durch eine Phase III-Studie die kombinierte PUVA-IFN-α Behandlung als ein Standard in den Stadien IA-IIB etabliert werden. In-vitro-Daten erharten zunehmend die (patho)physiologische Bedeutung des IL-12, so dass die Substitutionstherapie bereits in Phase I-Studien untersucht wurde. Weitere therapeutische Ansatze sind neben IL-2 und IFN-γ das fusionierte Zytokin-Toxin-Molekule DAB389IL-2. Beim B-Zell-Lymphom werden Antikorper-IL-2-Fusionsproteine untersucht. Fur Spinaliome und Basalzellkarzinome, speziell bei inoperablem Status, ist die lokale IFN-α-Therapie eine mogliche Option. Und auch beim Merkel-Zell-Karzinom kann bei Rezidiv oder Progress der Einsatz von IFN-α oder aber auch TNF-α erwogen werden. Die Domane der Zytokintherapien in der dermatologischen Onkologie ist nach aktuellem Stand dem Melanom und dem T-Zell-Lymphom vorbehalten und findet da zumeist in multimodalen Ansatzen ihre Anwendung.
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- 2001
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6. Satellite Symposium at the 7th Congress of the European Academy of Dermatology and Venereology, Nice, October 9, 1998
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E. Stockfleth, C.R. de Potter, T. Rufli, J. Lambert, D. Zillikens, L.R. Braathen, G. Piérard, T. Lahaye, M. Song, M. de la Brassinne, G.E. Piérard, J.E. Arrese, Ch.C. Zouboulis, E. Christophers, G.L. Capella, Y. Sasaki, L. Sponagel, Y. Sadamoto, L Segura Puertas, F. Brouers, F.H.J. van den Hoogen, H. Degreef, M. Heenen, T. Nishikawa, S. de Mare, M. Bauwens, M. Inada, J.-M. Schröder, A.J. Kanwar, S. Yamada, T. Pohle, S. Magina, P. Itin, S. Dhar, I. Uhoda, S. Malakar, J. Drewe, C. Hernandez-Pion, C. Degraeve, R. Cecchi, N. Lateur, C. Fracchiolla, T.A. Luger, A. Alomar, I. Antunes, U. Sass, B. Meinke, K. Higuchi, R. Brehler, T. Hermanns-Lê, R.E. Hunger, P. Bisschop, J.M. Lachapelle, B. Coessens, R. Taberner, C. Piérard-Franchimont, P. Paquet, C.U. Brand, M. Sticherling, J.M. Naeyaert, J. Senneseael, R. Arndt, M. Anseeuw, D. Roseeuw, R.M. Pujol, J. André, F. Henry, I. Fumal, R. Lemos, G.P. Thami, J. Mesquita-Guimarães, S. Wustlich, O. Neofotistou, K. Kato, T. Koga, C. Diaz, E.-C. Foerster, U. van Haelst, G. Altomare, T. Meyer, C. Nadal, N.P. Stratigeas, A. Hubert, P. Gheeraert, M. Furue, Y. Abe, N. Gyr, M. Cassé, J. Miralles, M. Imamura, A. De Coninck, A. Giomi, A.L. Fraiture, J.-Ch. Noël, J.W. Burnett, B.E. Paredes, S. Courvoisier, M.M.B. Seyger, A.C. Katoulis, V. Goeteyn, E.M.G.J. de Jong, E. Heimer de la Cotera, M.A. Barros, H. Dhivert-Donnadieu, R. Kuroki, P. Dupuy, A. Looks, O. Heymans, H. Shimizu, D. Lange, E. Granjo, A. Theunis, J. Fissette, S. Blacher, N.A. Schaub, A. Elíseo, W. Domschke, U. Wollina, N.G. Stavrianeas, A. Jortay, M. Médot, C. Neamonitos, F. André, B. Heykarts, J. Pinton, E. Bornscheuer, L. Gilli, E. Frigerio, and M. Battegay
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medicine.medical_specialty ,Venereology ,business.industry ,Ophthalmology ,medicine ,Library science ,Nice ,Dermatology ,business ,computer ,computer.programming_language - Published
- 1999
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7. 1–14 Prélude: Macrophages in Inflammation / 15–35 Macrophages in Anti-Inflammation: Molecular Mechanisms / 36–46 Macrophages in Anti-Inflammation: Apoptosis / 47–56 Macrophages in Anti-Inflammation: Induction of Tolerance
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F. Henry, Nahid Hakiy, F. Petersen, Edgar Dippel, Claus Kerkhoff, Gert Riethmüller, Kerstin Wolk, Claus-Detlev Klemke, Claudia Poppe, D.-H. Kalden, Andrew J. Rees, Christine Schütt, Kai Schledzewski, Vitam Kodelja, Ines Eue, K. Meflah, Len W. Poulter, G. Schmitz, M. Kauer, M. Ritter, Knut Schäkel, Robert Birk, Lukas Perler, M. Bodzioch, Thomas W. Jungi, T.A. Hamilton, T. Brzoska, Bernard Uitdehaag, Volker von Baehr, W. Drobnik, B. Scheuerer, Leonie S. Taams, Birgit Klein, E. Grage-Griebenow, P'ng Loke, H. Horowitz, Li Li, H. Tabel, T. Orlikowsky, Robert Sabat, R.S. Kaushik, J. Uzonna, E. Orsó, S. Martin, E. Brandt, Hans-Dieter Volk, J. Pryjma, Manfred Kauer, B. Lieubeau, G.E. Dannecker, M. Ernst, Ernst Peterhans, T. Vogl, Abalokita Chakraborty, Sergij Goerdt, Anne Devine, Andrew S. MacDonald, Wayne P. Pearce, C. Büchler, M. Porsch-Özcürümez, Ernst Peter Rieber, I. Barbieux, J. Baran, Clemens Sorg, Jan W. Koper, K. Steinbrink, Arne N. Akbar, C. Buechler, Z.-Q. Wang, Nitya G. Chakraborty, W.E. Kaminski, R. Kishore, J.M. Tebo, Gabriele Zwadlo-Klarwasser, Miguel J. Stadecker, Constantin E. Orfanos, R. Stumpo, J. Klucken, Judith E. Allen, Wolf-Dietrich Döcke, E. Macher, Bijay Mukherji, Y. Ohmori, H.-D. Flad, M. Grégoire, M.K. Hoffmann, Ruth Schiffer, Malcolm H.A. Rustin, T.E. Scholzen, Bernd Klosterhalfen, Hubert Kolb, T. Langmann, Oliver Politz, C. Sorg, J. Pior, Jurgen Jansen, L. Bretaudeau, H. Kolb, Pierre Guillot, Yoong-Eun Kim, Lars-Peter Erwig, A. Hequet, Christine Federle, Timo K. van den Berg, Alexej Gratchev, Volker Burkart, Michael S. McGrath, T.A. Luger, Elfriede Mayer, Robert N. Barker, D. Niethammer, and Matthias Schweizer
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business.industry ,Adipose tissue macrophages ,Inflammation ,Anti inflammation ,Cell Biology ,General Medicine ,Pathology and Forensic Medicine ,Cell biology ,Apoptosis ,Cancer research ,Medicine ,medicine.symptom ,business ,Molecular Biology - Published
- 1999
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8. Splicing variants of the human growth hormone mRNA: detection in pituitary, mononuclear cells and dermal fibroblasts
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T.A. Luger, A. Palmetshofer, D. Zechner, and A. Barta
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Molecular Sequence Data ,Gene Expression ,Biology ,Transfection ,Polymerase Chain Reaction ,Biochemistry ,Cell Line ,Dermal fibroblast ,Paracrine signalling ,Exon ,Endocrinology ,RNA, Messenger ,Autocrine signalling ,Molecular Biology ,Gene ,Skin ,Messenger RNA ,Base Sequence ,Alternative splicing ,Exons ,Fibroblasts ,Placental Lactogen ,Molecular biology ,Alternative Splicing ,Growth Hormone ,Pituitary Gland ,Protein Biosynthesis ,embryonic structures ,RNA splicing ,Leukocytes, Mononuclear ,Sequence Analysis ,Cell Division - Abstract
The human growth hormone/human chorionic somatomammotropin (hGH/hCS) gene cluster contains five genes: hGH-N, hGH-V, hCS-A, hCS-B, and hCS-L. In this study, the nature of splicing products of their primary transcripts (except hCS-L) was analyzed by nuclease mapping as well as by reverse transcription-polymerase chain reaction (RT-PCR) experiments. All the previously described hGH-N mRNAs encoding the normal 22-K growth hormone, the 20-K variant as well as a transcript lacking the third exon were found in pituitary tissue and in transiently transfected human 293-S cells. In addition, splicing products lacking either exons 3 and 4 or exons 2, 3 and 4 were found in both tissues. In accordance to previously reported data,the hGH-V, the hCS-A and the hCS-B genes which are expressed in placental tissue give rise to the 22-K mRNA but not to 20-K mRNA. Furthermore, no hCS mRNA arising from skipping of exon 3 was present, whereas mRNAs arising from ligation of exon 2 to exon 5 and of exon 1 to exon 5 were clearly detectable. The various hGH cDNAs were expressed in vivo and screened for lactogenic activity. Only the 22-K and the 20-K variant were active in this assay. All of the hGH-N-derived differentially processed RNAs were found in cell lines of lymphoid (Hut-78) and of myelomonocytic type (U937), which had been recently described to secrete growth hormone. Interestingly, RT-PCR analysis allowed the determination of hGH-N transcripts in dermal fibroblasts. This finding underlines the importance of growth hormone in influencing immune system development and further suggests possible autocrine/paracrine regulatory loops in skin tissue.
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- 1995
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9. CIRCULATING SERUM LEVELS OF INTERLEUKIN 6 AND C-REACTIVE PROTEIN AFTER LIVER TRANSPLANTATION
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Walter E. Aulitzky, T.A. Luger, Manfred Herold, J Nordberg, Ch. Huber, Raimund Margreiter, Herbert Tilg, and Wolfgang Vogel
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Graft Rejection ,Antiserum ,Transplantation ,biology ,Interleukin-6 ,business.industry ,medicine.medical_treatment ,C-reactive protein ,Interleukin ,Bacterial Infections ,Liver transplantation ,Liver Transplantation ,C-Reactive Protein ,Cytokine ,Cytomegalovirus Infections ,Immunology ,medicine ,biology.protein ,Humans ,Tumor necrosis factor alpha ,business ,Interleukin 6 - Abstract
The study objectives were to investigate serum levels of interleukin-6 and C-reactive protein (CRP) after liver transplantation to correlated measurements with various clinical parameters. Twenty-three patients were studied after orthotopic liver transplantation. Serum IL-6 activity was evaluated by testing its capacity to induce proliferation of the IL-6-dependent hybridoma cell line B9. CRP was assessed by a nephelometric method. Only two of seven patients with acute cellular rejection developed an increase of serum IL-6 and CRP. In contrast to this rejection group, elevated IL-6 levels were observed in 7/9 patients with bacterial infections. Peak values for IL-6 were observed one day and for CRP two days after clinical diagnosis of infection. CMV disease was also associated with markedly increased IL-6 and CRP levels in 5/7 patients. Surprisingly, levels in this condition were approximately in the same range as in bacterial infection. IL-6 and CRP serum levels seen in bacterial infection and CMV disease were significantly higher than those in rejection (P less than 0.001). Serum IL-6 activity was neutralized by an antiserum directed against recombinant human IL-6. Preferential elevations of IL-6 and CRP represent one feature of bacterial and viral infections. Elevation of TNF during rejection as described earlier is only rarely accompanied by increased serum IL-6 levels.
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- 1992
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10. Contents Vol. 200, 2000
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L.R. Braathen, Tsutomu Fujimura, M. Barten, Konstanze Spieth, C. Seipp, Paul L. Bigliardi, J.-H. Saurat, Roland Kaufmann, M. Derighetti, Antonio Del Sorbo, W. Bodemer, R. Zimmermann, Tokihiko Shimada, C.U. Brand, P. Rohner, Hans-Joachim Schulz, S. Aractingi, P. Reygagne, R.G. Panizzon, Shoko Shimada, Y.X. Zhen, M. Laporte, M.V. Kuipers, M. Böhm, D. de Hoop, Yoshinori Takema, Roland Böni, Elvira Masturzo, M. Streit, J.F. Silvestre, Kazunari Usuki, B.E. Paredes, Genji Imokawa, D. Guggisberg, A. Etienne, J.-P. Cerottini, C. Bachmeyer, I. Betlloch, J. Bañuls, S. Lu, B. Ninet, L. Toutous-Trellu, Uwe Wollina, M. Tanaka, D. Fokan, M. Pechère, G. Bonsmann, Oliver P Kreyden, Günter Burg, M. Fathi, Kazue Tsukahara, Shigeru Moriwaki, K. O’Goshi, N. Tabata, S. Rüegger, K. Biel, Francesco Borgia, S. Krähenbühl, Rudolf Happle, Jens Gille, R. Botella, A.M. Kligman, R.E. Hunger, S. Miyakawa, T.A. Luger, Thomas Zaugg, Andreas J. Bircher, H. Tagami, Jürg Meyer, Serafinella P. Cannavò, Walter H.C. Burgdorf, P.C.M. van de Kerkhof, Mario Vaccaro, C. de Graef, Biagio Guarneri, S.A. Cobelens, R. Ramón, R. Auckenthaler, B. Krayenbühl, P.-A. Piletta, Giuseppe Monfrecola, Jann Lübbe, Mitsuhiro Sekiyama, C. Quattroppani, M. Grimaître, Soili Mäkinen-Kiljunen, Tim Graefe, G. Burg, G. Gross, C. Ostwald, Reinhard Dummer, D. Hohl, J. Navas, J. de Korte, Anna Maria Riccardo, S. Shimizu, P. Galand, W.Y.M. Tang, A. Pires, Tamotsu Kanzaki, B. Noël, K. Buxtorf, M. Heenen, B.H. Krayenbühl, and Takashi Kitahara
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Dermatology - Published
- 2000
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11. Contents Vol. 67, 1999
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Birgit Klein, Vitam Kodelja, Oliver Politz, A. Hequet, Len W. Poulter, S. Martin, L. Bretaudeau, Anne Devine, Knut Schäkel, Arne N. Akbar, Kerstin Wolk, Matthias Schweizer, Z.-Q. Wang, Wayne P. Pearce, D.-H. Kalden, Claus-Detlev Klemke, Bernd Klosterhalfen, Claudia Poppe, Wolf-Dietrich Döcke, Hubert Kolb, G. Schmitz, M. Kauer, M. Ritter, Christine Federle, H. Kolb, H. Horowitz, J. Pior, Y. Ohmori, K. Meflah, Robert Birk, Timo K. van den Berg, H.-D. Flad, M. Grégoire, Li Li, M.K. Hoffmann, Miguel J. Stadecker, Christine Schütt, Alexej Gratchev, Ruth Schiffer, Jurgen Jansen, Kai Schledzewski, J. Uzonna, Malcolm H.A. Rustin, Ernst Peterhans, Pierre Guillot, Yoong-Eun Kim, Abalokita Chakraborty, Andrew S. MacDonald, K. Steinbrink, Volker Burkart, Gert Riethmüller, Andrew J. Rees, E. Brandt, J. Pryjma, Michael S. McGrath, J.M. Tebo, T. Vogl, Leonie S. Taams, Gabriele Zwadlo-Klarwasser, Sergij Goerdt, T.A. Luger, E. Grage-Griebenow, C. Büchler, T.E. Scholzen, Edgar Dippel, J. Klucken, Claus Kerkhoff, Judith E. Allen, F. Henry, Nahid Hakiy, F. Petersen, Lukas Perler, M. Porsch-Özcürümez, R. Stumpo, E. Macher, M. Bodzioch, T. Langmann, J. Baran, Elfriede Mayer, C. Sorg, Robert N. Barker, Ines Eue, D. Niethammer, R. Kishore, Ernst Peter Rieber, I. Barbieux, Thomas W. Jungi, Constantin E. Orfanos, Clemens Sorg, Jan W. Koper, M. Ernst, T.A. Hamilton, Lars P. Erwig, W. Drobnik, Robert Sabat, H. Tabel, T. Orlikowsky, R.S. Kaushik, E. Orsó, Manfred Kauer, B. Lieubeau, Bijay Mukherji, P'ng Loke, C. Buechler, Nitya G. Chakraborty, W.E. Kaminski, T. Brzoska, Bernard Uitdehaag, Volker von Baehr, B. Scheuerer, Hans-Dieter Volk, and G.E. Dannecker
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Cell Biology ,General Medicine ,Molecular Biology ,Pathology and Forensic Medicine - Published
- 1999
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12. Subject Index Vol. 217, 2008
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Josep Malvehy, F. Berard, Mauro Picardo, Carlo Tomino, Natalija Novak, Eugenia Caggese, Tetsuya Higuchi, Cataldo Patruno, Michiie Sakamoto, G. Safa, Pablo F. Peñas, T.A. Luger, Thomas Bieber, Knut Schäkel, G. Gupta, Daniele Torchia, Thomas Ruzicka, Susana Puig, N. Okiyama, Emilio Pedrosa, Renato G. Panizzon, M. Loppin, Mario Arico, Lucia Gallo, Michael Meurer, Paola Bertuccio, Masayuki Kimoto, Paula Aguilera, Abdul-Ghani Kibbi, Uta Schwanebeck, Carmelo Urso, Anna Balato, Alexander V. Kuznetsov, Rosanna Cuscito, María Jones-Caballero, Mirjana Urosevic, Peter Weisenseel, J. Lamoril, N.H. Shear, Masaru Tanaka, I. Katayama, T. Satoh, Luca Borradori, B. Ben-Said, Ghassan Awar, Fabio Ayala, F.G. Larsen, Joerg C. Prinz, Nicola Balato, Reinhard Dummer, K. Nishioka, Mazen Kurban, Shigeki Inui, L. Tisseau, O. Lejeune, Liliane Chatenoud, J.F. Nicolas, Patrick A. Oberholzer, Carola Berking, Antonio Addis, Hans C. Steinert, Samer Ghosn, Hiroo Yokozeki, Gabriel Salerni, Y. Chaves, Dagmar Wilsmann-Theis, Alberto Giannetti, P. Kidson, Maria Rita Bongiorno, Cristina Carrera, Marlies Wakkee, Giovanni Maria Palleschi, Zenus Saleh, N. Ueda, M. Bourcier, Takahiro Satoh, Xina Grählert, F. Cambazard, Satoshi Itami, Sergio Chimenti, G. Duarte, Anastasia A. Garrido-Ríos, Sonja Molin, Mara Maccarone, H. Yokozeki, Eugenio Torre, T. Simonart, Luigi Naldi, Hitoshi Iyatomi, F. Clonier, Jochen Schmitt, Emmanuel Laffitte, J. Tebib, Tamar Nijsten, Takeshi Nakajima, and H. Kohsaka
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Index (economics) ,Statistics ,Subject (documents) ,Dermatology ,Mathematics - Published
- 2008
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13. Alpha melanocyte stimulating hormone and fragments: Components of the cutaneous defense and therapeutic potential
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T.A. Luger and T. Brzoska
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Cellular and Molecular Neuroscience ,chemistry.chemical_compound ,Endocrinology ,Neurology ,chemistry ,Endocrine and Autonomic Systems ,Cancer research ,General Medicine ,Biology ,alpha-Melanocyte-stimulating hormone - Published
- 2006
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14. Subject Index Vol. 200, 2000
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L.R. Braathen, B. Ninet, S. Rüegger, R. Auckenthaler, D. de Hoop, D. Guggisberg, Tokihiko Shimada, J. Bañuls, S. Aractingi, Soili Mäkinen-Kiljunen, R.E. Hunger, D. Fokan, M. Fathi, T.A. Luger, S. Miyakawa, C. Bachmeyer, Jürg Meyer, M. Tanaka, Andreas J. Bircher, I. Betlloch, Francesco Borgia, S.A. Cobelens, Kazunari Usuki, B.H. Krayenbühl, Yoshinori Takema, W. Bodemer, Uwe Wollina, R. Botella, A.M. Kligman, H. Tagami, G. Bonsmann, Walter H.C. Burgdorf, B.E. Paredes, Genji Imokawa, Roland Böni, R. Ramón, B. Noël, Shoko Shimada, C. de Graef, R. Zimmermann, M. Böhm, M. Heenen, K. Biel, J. de Korte, C. Ostwald, B. Krayenbühl, S. Lu, Oliver P Kreyden, Kazue Tsukahara, Günter Burg, W.Y.M. Tang, C. Seipp, M. Derighetti, Konstanze Spieth, J.F. Silvestre, Y.X. Zhen, P.C.M. van de Kerkhof, Giuseppe Monfrecola, Elvira Masturzo, Reinhard Dummer, D. Hohl, J.-P. Cerottini, Anna Maria Riccardo, S. Shimizu, P. Galand, M. Grimaître, J. Navas, N. Tabata, L. Toutous-Trellu, K. O’Goshi, G. Burg, G. Gross, Serafinella P. Cannavò, Mitsuhiro Sekiyama, A. Pires, Thomas Zaugg, Roland Kaufmann, C. Quattroppani, P.-A. Piletta, M. Laporte, C.U. Brand, Shigeru Moriwaki, P. Rohner, Hans-Joachim Schulz, R.G. Panizzon, Mario Vaccaro, Biagio Guarneri, M. Barten, S. Krähenbühl, J.-H. Saurat, M. Streit, A. Etienne, Jens Gille, Tim Graefe, Jann Lübbe, Takashi Kitahara, K. Buxtorf, Tsutomu Fujimura, Paul L. Bigliardi, Tamotsu Kanzaki, Antonio Del Sorbo, M. Pechère, Rudolf Happle, M.V. Kuipers, and P. Reygagne
- Subjects
Index (economics) ,Statistics ,Subject (documents) ,Dermatology ,Mathematics - Published
- 2000
- Full Text
- View/download PDF
15. Subject Index Vol. 67, 1999
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D.-H. Kalden, Ines Eue, Wayne P. Pearce, K. Meflah, Y. Ohmori, B. Lieubeau, Christine Federle, Clemens Sorg, Vitam Kodelja, K. Steinbrink, H.-D. Flad, Timo K. van den Berg, G. Schmitz, Jan W. Koper, Edgar Dippel, M.K. Hoffmann, Ruth Schiffer, Alexej Gratchev, H. Tabel, T. Orlikowsky, M. Kauer, R.S. Kaushik, M. Ritter, E. Orsó, J. Uzonna, Robert Sabat, Len W. Poulter, L. Bretaudeau, J. Klucken, J.M. Tebo, Volker Burkart, Robert Birk, Michael S. McGrath, E. Brandt, Judith E. Allen, R. Stumpo, Knut Schäkel, T.A. Luger, J. Pryjma, Gabriele Zwadlo-Klarwasser, Kerstin Wolk, Wolf-Dietrich Döcke, E. Macher, Leonie S. Taams, Hans-Dieter Volk, H. Kolb, Claus Kerkhoff, Manfred Kauer, A. Hequet, Oliver Politz, E. Grage-Griebenow, Claus-Detlev Klemke, Miguel J. Stadecker, G.E. Dannecker, R. Kishore, Li Li, Bijay Mukherji, Claudia Poppe, S. Martin, Gert Riethmüller, M. Grégoire, Lars-Peter Erwig, Thomas W. Jungi, Hubert Kolb, T.A. Hamilton, Arne N. Akbar, C. Buechler, Malcolm H.A. Rustin, Birgit Klein, Z.-Q. Wang, Nitya G. Chakraborty, Constantin E. Orfanos, W. Drobnik, T. Vogl, J. Pior, Bernd Klosterhalfen, F. Henry, Nahid Hakiy, Lukas Perler, Abalokita Chakraborty, T.E. Scholzen, Andrew S. MacDonald, W.E. Kaminski, T. Langmann, Andrew J. Rees, Christine Schütt, Kai Schledzewski, Sergij Goerdt, Pierre Guillot, M. Ernst, Yoong-Eun Kim, M. Porsch-Özcürümez, F. Petersen, Elfriede Mayer, Jurgen Jansen, C. Büchler, J. Baran, Anne Devine, T. Brzoska, Bernard Uitdehaag, Volker von Baehr, B. Scheuerer, Ernst Peter Rieber, I. Barbieux, C. Sorg, Robert N. Barker, Ernst Peterhans, M. Bodzioch, D. Niethammer, Matthias Schweizer, P'ng Loke, and H. Horowitz
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Index (economics) ,Statistics ,Subject (documents) ,Cell Biology ,General Medicine ,Molecular Biology ,Pathology and Forensic Medicine ,Mathematics - Published
- 1999
- Full Text
- View/download PDF
16. Acknowledgement to Referees for Dermatology 2008
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Pablo F. Peñas, T.A. Luger, María Jones-Caballero, G. Duarte, Emmanuel Laffitte, N. Okiyama, F. Clonier, Anastasia A. Garrido-Ríos, J. Tebib, Carola Berking, N. Ueda, Tamar Nijsten, Thomas Bieber, G. Gupta, Alberto Giannetti, Carmelo Urso, Sonja Molin, M. Bourcier, Samer Ghosn, Rosanna Cuscito, K. Nishioka, Dagmar Wilsmann-Theis, J.F. Nicolas, Takeshi Nakajima, T. Satoh, Satoshi Itami, T. Simonart, Mara Maccarone, H. Yokozeki, Natalija Novak, Maria Rita Bongiorno, Eugenio Torre, Paula Aguilera, Mirjana Urosevic, Cataldo Patruno, Hiroo Yokozeki, Sergio Chimenti, Knut Schäkel, Michiie Sakamoto, Paola Bertuccio, Gabriel Salerni, F. Cambazard, Peter Weisenseel, Y. Chaves, Shigeki Inui, I. Katayama, Luigi Naldi, O. Lejeune, Zenus Saleh, Antonio Addis, Masayuki Kimoto, Hitoshi Iyatomi, Fabio Ayala, Liliane Chatenoud, Jochen Schmitt, Anna Balato, F.G. Larsen, Takahiro Satoh, H. Kohsaka, L. Tisseau, Mazen Kurban, Reinhard Dummer, Uta Schwanebeck, Carlo Tomino, Giovanni Maria Palleschi, Daniele Torchia, Susana Puig, Thomas Ruzicka, Renato G. Panizzon, Alexander V. Kuznetsov, Nicola Balato, P. Kidson, Cristina Carrera, Patrick A. Oberholzer, Marlies Wakkee, Mauro Picardo, Emilio Pedrosa, Mario Arico, Lucia Gallo, Masaru Tanaka, N.H. Shear, Joerg C. Prinz, G. Safa, Abdul-Ghani Kibbi, J. Lamoril, M. Loppin, Xina Grählert, Michael Meurer, Luca Borradori, B. Ben-Said, Ghassan Awar, Hans C. Steinert, Eugenia Caggese, Tetsuya Higuchi, Josep Malvehy, and F. Berard
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Medical education ,Acknowledgement ,Dermatology ,Psychology - Published
- 2008
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17. C057 Mediators of immunity and inflammation
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T.A. Luger
- Subjects
Infectious Diseases ,Immunity ,business.industry ,Immunology ,medicine ,Inflammation ,Dermatology ,medicine.symptom ,business - Published
- 1997
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18. S158 Immunomodulating function of neuro-hormones
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T.A. Luger
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Infectious Diseases ,business.industry ,Medicine ,Dermatology ,business ,Neuroscience ,Function (biology) ,Hormone - Published
- 1997
- Full Text
- View/download PDF
19. S009 New therapeutic approaches for psoriasis
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T.A. Luger
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medicine.medical_specialty ,Infectious Diseases ,business.industry ,Psoriasis ,Medicine ,Dermatology ,business ,medicine.disease - Published
- 1997
- Full Text
- View/download PDF
20. Cytokines: synthesis and release by epidermal cells under conditions of inflammation
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T.A. Luger
- Subjects
Pharmacology ,Chemistry ,medicine ,Cancer research ,Inflammation ,medicine.symptom - Published
- 1990
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21. Acute phase reaction after liver transplantation: Cytokines and their products
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Manfred Herold, C. Huber, Walter E. Aulitzky, Wolfgang Vogel, R. Margreiter, Herbert Tilg, and T.A. Luger
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medicine.medical_specialty ,Hepatology ,business.industry ,Internal medicine ,medicine.medical_treatment ,Acute-phase protein ,medicine ,Liver transplantation ,business ,Gastroenterology - Published
- 1990
- Full Text
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22. Purification of human interleukin 1 by high-performance liquid chromatography
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T.A. Luger and A. Köck
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Chromatography ,Elution ,Sodium ,Organic Chemistry ,Size-exclusion chromatography ,chemistry.chemical_element ,Interleukin ,General Medicine ,Hydroxylapatite ,Phosphate ,Biochemistry ,High-performance liquid chromatography ,Chromatography, DEAE-Cellulose ,Analytical Chemistry ,chemistry.chemical_compound ,chemistry ,Humans ,Specific activity ,Lymphocytes ,Cells, Cultured ,Chromatography, High Pressure Liquid ,Serum Albumin ,Interleukin-1 - Abstract
The utility of high-performance liquid chromatography (HPLC) in the purification of Interleukin 1 (IL 1, lymphocyte-activating factor) has been investigated Human IL 1-containing supernatants were concentrated by lyophilization and desalted using Bio-Gel P-6 DG desalting gel. Subsequently, the sample containing IL 1 activity was subjected to HPLC with a novel HPHT hydroxylapatite column. Using a sodium phosphate gradient, IL 1 was eluted as a single peak of activity separated from the major protein contaminant, yielding 90% recovery and a specific activity of 6.3 X 10(4) U/mg. Pooled fractions from Bio-Gel HPHT were concentrated and subjected either to Bio-Sil IEX 540 DEAE anion-exchange or Bio-Sil TSK 125 size exclusion chromatography. From DEAE the IL 1 activity was eluted before a linear sodium chloride gradient was started, whereas the protein contaminant was eluted at 110 mM NaCl. When TSK was used IL 1 activity was eluted within a molecular weight range of 20,000-10,000. Fractions from the DEAE or TSK columns that were positive for IL 1 activity did not contain detectable protein, suggesting a good resolution. Furthermore, the recovery from DEAE was 26% whereas TSK 125 yielded 119% of the original activity. The specific activities were 6 X 10(7) and 2.5 X 10(8) U/mg, respectively. Thus, this method provides a rapid and reproducible procedure for the purification if IL 1 for further biological characterization.
- Published
- 1984
- Full Text
- View/download PDF
23. New trends in photobiology
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T. Schwarz and T.A. Luger
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Radiation ,Radiological and Ultrasound Technology ,medicine.medical_treatment ,Biophysics ,Interleukin ,Inflammation ,Biology ,Granulocyte ,Immune system ,medicine.anatomical_structure ,Cytokine ,Immunology ,biology.protein ,medicine ,Radiology, Nuclear Medicine and imaging ,Secretion ,medicine.symptom ,Interleukin 6 ,Keratinocyte - Abstract
Within the last decade it has been found that the keratinocyte is not only a mechanical barrier to the outside but is also a fully immunocompetent cell that can release immunomodulating cytokines such as interleukin (IL) 1, IL 3, IL 6 and colony-stimulating factors (CSF). The constitutive production of these mediators by keratinocytes both in vivo and in vitro is very low; however, it can be dramatically enhanced by various stimuli such as tumour promotors or endotoxin. In addition, UV light is one of the most potent inducers of cytokine release. Accordingly, UV exposure results in increased production of IL 1, IL 3, IL 6, tumour necrosis factor and granulocyte/macrophage-CSF by epidermal cells. The secretion of these cytokines causes local immunologic and inflammatory reactions following UV irradiation. These factors, however, may also enter the circulation and thus may be responsible for systemic effects. In addition, UV light causes keratinocytes to release immunosuppressive factors which block contact hypersensitivity reaction and IL 1 activity. The production of such immunoinhibitors may play an essential pathogenic role during systemic UV-induced immunosuppression. This review will focus on the biological effects of epidermal-cell-derived cytokines, whose release is induced by UV light, and their role in immunologic and inflammatory reactions following UV exposure will be discussed.
- Published
- 1989
- Full Text
- View/download PDF
24. High-performance liquid chromatographic separation of distinct epidermal cell-derived cytokines
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A. Köck and T.A. Luger
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Sodium ,chemistry.chemical_element ,Biochemistry ,High-performance liquid chromatography ,Analytical Chemistry ,Cell Line ,chemistry.chemical_compound ,Mice ,Animals ,Chromatography, High Pressure Liquid ,Biological Products ,Chromatography ,Elution ,Chromatofocusing ,Organic Chemistry ,Interleukin ,General Medicine ,Hydrogen-Ion Concentration ,Phosphate ,Molecular Weight ,Thymocyte ,chemistry ,Epidermal Cells ,Cell culture ,Cytokines ,Interleukin-2 ,Epidermis ,Interleukin-1 - Abstract
High-performance liquid chromatography (HPLC) is useful for the purification and separation of immunoregulatory cytokines, such as macrophage-derived interleukin 1 (IL 1). In addition to macrophages, epidermal cells also release a mediator, epidermal cell (EC) derived thymocyte-activating factor (ETAF), whcih cannot be separated from IL 1. Moreover, it has been shown recently that EC produce a distinct interleukin 3-like mast cell-activating factor (EC IL 3). This study was performed to investigate whether HPLC may be useful for the separation of EC-derived cytokines, such as ETAF and EC IL 3. For factor production, a murine EC line (Pam 212) was used. ETAF activity was measured using the thymocyte costimulator assay. EC IL 3 was was determined by induction of the proliferative activity of an IL 3-dependent cell line (32 DCL). Using a TSK 125 size-exclusion column and phosphate-buffered saline (pH 7.2) as the mobile phase, ETAF was eluted with an apparent molecular weight of 17 kD, and EC IL 3 with a molecular weight of 28 kD. When EC supernatants were chromatofocused on a Mono P column, ETAF activity was eluted with apparent p I values of 6.8, 6.2 and 5.3, and ECL IL 3 activity with p I 7.8, 7.4 and 7.1. When reversed-phase HPLC (RP-HPLC) (equilibration with water and a 0–100% concave acetonitrile gradient) was applied ETAF exhibited four distinct peaks, whereas EC IL 3 was eluted as one major peak between 70 and 80% acetonitrile. Separation on a Bio-Gel HPHT column with a sodium phosphate gradient was not satisfactory, but the recovery was high. It is concluded that chromatofocusing on Mono P and RP-HPLC are suitable methods for the separation of cytokines, such as ETAF and EC IL 3, both of which are produced by EC.
- Published
- 1985
25. Serial determination of serum ferritin levels in patients with malignant melanoma
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Robert Knobler, Werner Linkesch, T.A. Luger, and E. M. Kokoschka
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Oncology ,Male ,Cancer Research ,medicine.medical_specialty ,Pathology ,Skin Neoplasms ,Time Factors ,medicine.medical_treatment ,Pilot Projects ,Disease ,Text mining ,Internal medicine ,medicine ,Humans ,In patient ,Stage (cooking) ,Neoplasm Metastasis ,Serum ferritin ,Melanoma ,Neoplasm Staging ,Chemotherapy ,business.industry ,General Medicine ,Immunotherapy ,medicine.disease ,Ferritins ,Female ,business - Abstract
In a pilot study, serum ferritin levels of patients with malignant melanoma were found to be increased in stage III of the disease. Therefore, serial determinations were carried out up to 24 months in patients at various stages of the disease undergoing either chemo- or immunotherapy. Serum ferritin was determined by a two-site IRMA technique. Serum samples of 91 patients in different clinical stages of histologically verified malignant melanoma were included in these investigations. 80 healthy individuals were also investigated to determine normal ranges of serum ferritin. In stage III serum ferritin levels were significantly elevated (p less than 0,0005), whereas in stages I and II the values were within the normal range. Repeated serum ferritin levels of 10 patients in stage I and 13 patients in stages II and III without evidence of tumor progression were within the normal range. In 9 patients in stage III the increases in serum ferritin concentration correlated with the degree of dissemination of metastasis. Because of the occurrence of increased ferritin levels only in melanoma patients with progressive metastatic disease, the measurement of serum ferritin might have limited utility in clinical evaluation of melanoma patients as well as in the prediction of recurrence and in monitoring response to therapy.
- Published
- 1983
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