1. Molecularly imprinted cryogel membranes for mitomycin C delivery
- Author
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Kemal Çetin, Pınar Öncel, Aykut Arif Topçu, Handan Yavuz, Adil Denizli, Fen-Edebiyat Fakültesi, Cetin, Kemal -- 0000-0002-7393-7377, and TOPCU, Aykut Arif -- 0000-0002-5434-4920
- Subjects
Materials science ,Bulk polymerization ,Cell Survival ,Surface Properties ,Scanning electron microscope ,Mitomycin ,Acrylic Resins ,Biomedical Engineering ,Biophysics ,Bioengineering ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Cell Line ,Polymerization ,Molecular Imprinting ,Biomaterials ,Mice ,Drug Delivery Systems ,Materials Testing ,medicine ,Animals ,Humans ,Fourier transform infrared spectroscopy ,Chromatography ,Mitomycin C ,Membranes, Artificial ,021001 nanoscience & nanotechnology ,In vitro ,0104 chemical sciences ,Drug Liberation ,Cross-Linking Reagents ,Membrane ,Drug delivery ,Cryogel Membrane ,Mitomycin C Delivery ,Adsorption ,Swelling ,medicine.symptom ,0210 nano-technology ,Porosity ,Cryogels - Abstract
WOS: 000399567500002, PubMed: 28105892, In this study, cryogel-based implantable molecularly imprinted drug delivery systems were designed for the delivery of antineoplastic agent. Mitomycin C imprinted poly(2-hydroxyethyl methacrylate-N-methacryloyl-l-glutamic acid) cryogel membranes were produced by free-radical bulk polymerization under partially frozen conditions. The membranes were characterized by swelling tests, Fourier transform infrared spectroscopy, scanning electron microscopy, surface area measurements and in vitro hemocompatibility tests. In vitro delivery studies were carried out to examine the effects of cross-linker ratio and template content. Mitomycin C imprinted cryogel membranes have megaporous structure (10-100 mu m in diameter). The cumulative release of mitomycin C was decreased with increasing cross-linking agent ratio and increased with the amount of template in the cryogel structure. The nature of transport mechanism of the mitomycin C from the membranes was non-Fickian., TUBITAK-BIDEB2211-National Ph.D. Scholarship Programme, Kemal Cetin thanks The Scientific and Technological Research Council of Turkey (TUBITAK) for the support by 'TUBITAK-BIDEB2211-National Ph.D. Scholarship Programme'.
- Published
- 2017