1. Antifertility Activity ofQuassia amara: Quassin Inhibits the Steroidogenesis in Rat Leydig CellsIn Vitro
- Author
-
Joseph I. Okogun, Vincent C. O. Njar, Ebere U. Nduka, Taiwo O. Alao, Adeyombo F. Bolarinwa, and Yinusa Raji
- Subjects
Male ,medicine.medical_specialty ,Glaucarubin ,Pharmaceutical Science ,Biology ,Pharmacognosy ,Pharmacology ,Analytical Chemistry ,chemistry.chemical_compound ,Internal medicine ,Drug Discovery ,medicine ,Animals ,Quassia amara ,Testosterone ,Rats, Wistar ,Cells, Cultured ,Plants, Medicinal ,Quassins ,Leydig cell ,Organic Chemistry ,Leydig Cells ,Biological activity ,biology.organism_classification ,In vitro ,Rats ,Fertility ,medicine.anatomical_structure ,Endocrinology ,Complementary and alternative medicine ,chemistry ,Quassia ,Molecular Medicine ,Quassin - Abstract
The crude methanol extract of the stem wood of Quassia amara L. inhibited both the basal and LH-stimulated testosterone secretion of rat Leydig cells in a dose-dependent fashion. Fractionation of the extract by chromatography gave quassin (1) and 2-methoxycanthin-6-one (2); compound 1 proved to be the bioactive agent.
- Published
- 1995
- Full Text
- View/download PDF