1. Serum soluble Talin-1 levels are elevated in patients with multiple sclerosis, reflecting its disease activity.
- Author
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Muto M, Mori M, Liu J, Uzawa A, Uchida T, Masuda H, Ohtani R, Sugimoto K, and Kuwabara S
- Subjects
- Adult, Antibodies blood, Disability Evaluation, Female, Humans, Japan, Male, Middle Aged, Multiple Sclerosis, Relapsing-Remitting cerebrospinal fluid, Multiple Sclerosis, Relapsing-Remitting physiopathology, Severity of Illness Index, Statistics as Topic, Statistics, Nonparametric, Talin cerebrospinal fluid, Talin immunology, Young Adult, Multiple Sclerosis, Relapsing-Remitting blood, Talin blood
- Abstract
Previously, we identified anti-Talin-1 antibodies in the serum of MS. In this case, we measured the serum soluble Talin-1 (sTalin-1) levels by enzyme-linked immunosorbent assay. The serum sTalin-1 levels were significantly higher in 40 patients with MS than in 43 normal controls and in the acute phase of disease than in the remission phase. Interestingly, serum sTalin-1 levels were associated with a sustained increase in disability after MS attack but not with serum anti-Talin-1 antibody levels. sTalin-1 may be a biomarker for the acute phase of MS and may be used for the short-term prognosis of MS., (Copyright © 2017 Elsevier B.V. All rights reserved.)
- Published
- 2017
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