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8 results on '"Tan, Peizhu"'

1. Long-term low-dose alcohol intake promotes white adipose tissue browning and reduces obesity in mice

Author

Xuan, Xiuchen, primary, Tan, Peizhu, additional, Zhang, Ximei, additional, Huang, Hui, additional, Li, Yanze, additional, Jiang, Yu, additional, Yu, Aimiao, additional, Zhao, Yuanyuan, additional, Wang, Kuo, additional, Tang, Baozhu, additional, Qu, Shuye, additional, Jiang, Yunyan, additional, Xu, Jiaran, additional, Gao, Xu, additional, and Zhou, Lingyun, additional

Published
2022
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2. Enhancement of Solubility, Purification, and Inclusion Body Refolding of Active Human Mitochondrial Aldehyde Dehydrogenase 2

Author

Zhao, Tingting, primary, Huang, Hui, additional, Tan, Peizhu, additional, Li, Yanze, additional, Xuan, Xiuchen, additional, Li, Fenglan, additional, Zhao, Yuchen, additional, Cao, Yuwei, additional, Wu, Zhaojing, additional, Jiang, Yu, additional, Zhao, Yuanyuan, additional, Yu, Aimiao, additional, Wang, Kuo, additional, Xu, Jiaran, additional, Zhou, Lingyun, additional, and Yang, Dan, additional

Published
2021
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3. Long-term low-dose ethanol intake improves healthspan and resists high-fat diet-induced obesity in mice

Author

Diao, Yan, primary, Nie, Junhui, additional, Tan, Peizhu, additional, Zhao, Yuchen, additional, Zhao, Tingting, additional, Tu, Jiajie, additional, Ji, Heng, additional, Cao, Yuwei, additional, Wu, Zhaojing, additional, Liang, Huan, additional, Huang, Hui, additional, Li, Yanze, additional, Gao, Xu, additional, and Zhou, Lingyun, additional

Published
2020
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4. Low-dose ethanol intake prevents high-fat diet-induced adverse cardiovascular events in mice

Author

Nie, Junhui, primary, Ngokana, Linel Darrel, additional, Kou, Jiayuan, additional, Zhao, Yuchen, additional, Tu, Jiajie, additional, Ji, Heng, additional, Tan, Peizhu, additional, Zhao, Tingting, additional, Cao, Yuwei, additional, Wu, Zhaojing, additional, Wang, Qi, additional, Ren, Shuangfeng, additional, Xuan, Xiuchen, additional, Huang, Hui, additional, Li, Yanze, additional, Liang, Huan, additional, Gao, Xu, additional, and Zhou, Lingyun, additional

Published
2020
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5. SREBP1c mediates the effect of acetaldehyde on Cidea expression in Alcoholic fatty liver Mice

Author

He, Qi, primary, Diao, Yan, additional, Zhao, Tingting, additional, Hou, Baoyu, additional, Ngokana, Linel Darrel, additional, Liang, Huan, additional, Nie, Junhui, additional, Tan, Peizhu, additional, Huang, Hui, additional, Li, Yanze, additional, Qi, Lin, additional, Zhao, Yuanyuan, additional, Liu, Ying, additional, Gao, Xu, additional, and Zhou, Lingyun, additional

Published
2018
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6. Establishment of an alcoholic fatty liver disease model in mice

Author

Tan, Peizhu, primary, Liang, Huan, additional, Nie, Junhui, additional, Diao, Yan, additional, He, Qi, additional, Hou, Baoyu, additional, Zhao, Tingting, additional, Huang, Hui, additional, Li, Yanze, additional, Gao, Xu, additional, Zhou, Lingyun, additional, and Liu, Ying, additional

Published
2016
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8. Establishment of an alcoholic fatty liver disease model in mice.

Author

Tan, Peizhu, Liang, Huan, Nie, Junhui, Diao, Yan, He, Qi, Hou, Baoyu, Zhao, Tingting, Huang, Hui, Li, Yanze, Gao, Xu, Zhou, Lingyun, and Liu, Ying

Subjects
*FATTY liver, *ALCOHOLIC liver diseases, *DISEASE progression, *ANIMAL models of alcoholism, *MORTALITY of people with alcoholism, *PROTEIN expression, *THERAPEUTICS, *DISEASE risk factors, *IRON metabolism, *ANIMAL experimentation, *ASPARTATE aminotransferase, *BIOLOGICAL models, *CHOLESTEROL, *ETHANOL, *HIGH density lipoproteins, *LACTATE dehydrogenase, *LIPASES, *LIVER, *LOW density lipoproteins, *MICE, *OXIDOREDUCTASES, *OXIDATIVE stress, *ALANINE aminotransferase
Abstract

Background: Alcoholic fatty liver disease (AFLD) defines an important stage in the progression of alcoholic liver disease (ALD), which is a major cause of morbidity and mortality worldwide.Objective: To establish a mouse model of AFLD.Methods: Male C57BL/6 mice were divided into the following two groups: (i) a control group, which was allowed free access to food and water and (ii) an alcohol-treated group, which was administered a 15% (v/v) alcohol solution instead of water. After 8-9 months of treatment, serum biochemical indexes, histopathological changes, liver triglyceride content, iron storage, and ferritin light chain protein expression were measured using an automatic biochemical analyzer, hematoxylin-eosin (HE) staining, a commercially available kit, Prussian blue staining, and Western blot analysis, respectively.Results: Compared with the control group, the alcohol-treated group displayed increased levels of serum LDH, ALT, and AST, decreased levels of ALB, and no significant change in levels of TP. Additionally, increased levels of serum TG, T-CHO, and LDL and decreased levels of serum GLU and HDL were observed in the alcohol-treated mice. HE staining showed that lipid vacuolization occurred in the livers of alcohol-treated mice. The alcohol-treated mice also exhibited increased liver triglyceride content. Moreover, Prussian blue staining and Western blot analysis demonstrated that chronic alcohol administration caused iron overloading of the liver.Conclusions: Chronic administration of 15% (v/v) alcohol in the drinking water over 8-9 months caused AFLD in mice. Our results establish an AFLD model that represents a promising tool for the future study of the progression of ALD. [ABSTRACT FROM AUTHOR]

Published
2017
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