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Sirerenomelia is one of the uncommon and fatal congenital anomalies. Its main characteristic is the fusion of the lower limbs or lack of one of them, it is accompanied by other anomalies such as renal agenesis, absence of the sacrum, rectum and bladder and pulmonary hypoplasia. We present a case diagnosed at birth at Bacir Ben Nacer Hospital of Wilaya El Oued in Algeria, describing the clinical characteristics.

Se realizó unestudio descriptivo longitudinal y retrospectivo en el área de salud del policlinico universitario ¨José Martí¨en santiago de Cuba, durante el año 2014 y el primer semestre del 2015, con el objetivo de describir algunos aspectos relacionados con la prescripción en la tercera edad.El universo estuvo constituido por 532 pacientes de 60 años y mas que diero su consentimineto de participar en la investigacion y que staban dispensarizados como adultos mayores frágiles en 24 CMF de dos GBT.La información se procesó de forma computarizada para lo cual se creo una base de datos que permitió confeccionar tablas de contingencia de doble entrada donde se aplicó el porcentaje como medida resumen. Se comprobó que existió polifarmacia, con un prediminio del sexo femenino y es poco empeada la evaluación por geriatria para gaantizar la evaluación integral del anciano enfermo.Predominó la asociación de mas de dos enfermedades concomitantes incrementandose la posibilidad de interaccio medicamentosa y los farmacos mas empleados resultaro para patologias del SOMA seguidas de agentes co actividad a nivel cardiovascular.Prevaleció la indicación de terapia farmacológica por mas de un prescriptor en el mismo paciente.Se hace poco uso de los estudios renales y/o hepáticos para evitar o prevenir RAM e interacciones perjudiciales para el adulto mayor con polifarmacia.

Se realizó un estudio retrospectivo de observación analítica, de casos y controles, en 42 pacientes con artrosis de rodilla, pertenecientes al Policlínico Docente “José Martí Pérez” de Santiago de Cuba, de septiembre de 2014 ajunio de 2015, afin de evaluar la efectividad del producto homeopático AliviHo®-reuma como tratamiento coadyuvante unido al esquema terapéutico convencional basado en antiinflamatorios no esteroideos y analgésicos. En el procesamiento estadístico de la información se emplearon el porcentaje como medida de resumen, el test exacto de Fisher, para determinar si la asociación era significante, y la oportunidad relativa (OR), con un intervalo de confianza (IC) de 95 %. La favorable evolución en la mayoría de los pacientes reveló la utilidad de esta terapia adyuvante en la disminución de manifestaciones psicosomáticas y en el prolongamiento de los períodos de remisión de la enfermedad; de manera que quedó demostrada la efectividad del AliviHo®-reuma para tratar a pacientes con artrosis de rodilla y mejorar así la calidad de vida de estos.

Introducción: son múltiples y variados los beneficios que ofrece la lactancia materna, entre ellos, la disminución de la mortalidad y la morbilidad infantil. Si embargo, sigue siendo un grave problema el abandono precoz de la lactancia materna en los lactantes, antes del tiempo recomendado. Objetivo: identificar los factores que influyeron en el abandono precoz de la lactancia materna en lactantes. Materiales y Métodos: se realizó un estudio descriptivo transversal, en un universo conformado por los 120 lactantes que no recibieron lactancia materna exclusiva hasta el sexto mes, pertenecientes al Grupo Básico de Trabajo 1, del Policlínico “José Martí Pérez”, en Santiago de Cuba. El periodo comprendido fue desde enero a diciembre del 2014. Para la recolección de los datos se revisaron las historias clínicas de los lactantes y se elaboraron encuestas. Se procedió a la tabulación de los resultados los cuales quedaron recogidos en cuadros estadísticos. Resultados: predominaron e las madres multíparas en edades comprendidas entre 20 y 34 años de edad, para un 62,5 %. Un 27,5 % eran amas de casa, y un 25,8 % técnicos. El 65 % de las madres que participaron en el estudio tenían conocimientos sobre la lactancia materna, pero no recibieron suficiente apoyo de sus familiares. La mayoría de estos niños enfermaron, de ellos un 96,6 % padecieron enfermedades respiratorias agudas. La principal causa del abandono precoz fue la hipogalactia, con un 49,1 %. Conclusiones: se identificaron los factores que influyeron en el abandono precoz de la lactancia materna en lactantes.

Se realizó un estudio retrospectivo de observación analítica, de casos y controles, en 42 pacientes con artrosis de rodilla, pertenecientes al Policlínico Docente "José Martí Pérez" de Santiago de Cuba, de septiembre de 2014 a junio de 2015, a fin de evaluar la efectividad del producto homeopático AliviHo®-reuma como tratamiento coadyuvante unido al esquema terapéutico convencional basado en antiinflamatorios no esteroideos y analgésicos. En el procesamiento estadístico de la información se emplearon el porcentaje como medida de resumen, el test exacto de Fisher, para determinar si la asociación era significante, y la oportunidad relativa (OR), con un intervalo de confianza (IC) de 95 %. La favorable evolución en la mayoría de los pacientes reveló la utilidad de esta terapia adyuvante en la disminución de manifestaciones psicosomáticas y en el prolongamiento de los períodos de remisión de la enfermedad; de manera que quedó demostrada la efectividad del AliviHo®-reuma para tratar a pacientes con artrosis de rodilla y mejorar así la calidad de vida de estos

Background: Epidemiological research investigating the impact of exposure to plastics, and plastic-associated chemicals, on human health is critical, especially given exponentially increasing plastic production. In parallel with increasing production, academic research has also increased exponentially both in terms of the primary literature and ensuing systematic reviews with meta-analysis. However, there are few overviews that capture a broad range of chemical classes to present a state of play regarding impacts on human health. Methods: We undertook an umbrella review to review the systematic reviews with meta-analyses. Given the complex composition of plastic and the large number of identified plastic-associated chemicals, it was not possible to capture all chemicals that may be present in, and migrate from, plastic materials. We therefore focussed on a defined set of key exposures related to plastics. These were microplastics, due to their ubiquity and potential for human exposure, and the polymers that form the matrix of consumer plastics. We also included plasticisers and flame retardants as the two classes of functional additive with the highest concentration ranges in plastic. In addition, we included bisphenols and perand polyfluoroalkyl substances (PFAS) as two other major plastic-associated chemicals with significant known exposure through food contact materials. Epistemonikos and PubMed were searched for systematic reviews with meta-analyses, meta-analyses, and pooled analyses evaluating the association of plastic polymers, particles (microplastics) or any of the selected groups of high-volume plastic-associated chemicals above, measured directly in human biospecimens, with human health outcomes. Results: Fifty-two systematic reviews were included, with data contributing 759 metaanalyses. Most meta-analyses (78%) were from reviews of moderate methodological quality. Across all the publications retrieved, only a limited number of plastic-associated chemicals within each of the groups searched had been evaluated in relevant meta-analyses, and there were no meta-analyses evaluating polymers, nor microplastics. Synthesised estimates of the effects of plastic-associated chemical exposure were identified for the following health outcome categories in humans: birth, child and adult reproductive, endocrine, child neurodevelopment, nutritional, circulatory, respiratory, skin-related and cancers. Bisphenol A (BPA) is associated with decreased anoclitoral distance in infants, type 2 diabetes (T2D) in adults, insulin resistance in children and adults, polycystic ovary syndrome, obesity and hypertension in children and adults and cardiovascular disease (CVD); other bisphenols have not been evaluated. Phthalates, the only plasticisers identified, are associated with spontaneous pregnancy loss, decreased anogenital distance in boys, insulin resistance in children and adults, with additional associations between certain phthalates and decreased birth weight, T2D in adults, precocious puberty in girls, reduced sperm quality, endometriosis, adverse cognitive development and intelligence quotient (IQ) loss, adverse fine motor and psychomotor development and elevated blood pressure in children and asthma in children and adults. Polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs) but not other flame retardants, and some PFAS were identified and are all associated with decreased birth weight. In general populations, PCBs are associated with T2D in adults and endometriosis, bronchitis in infants, CVD, non-Hodgkin’s lymphoma (NHL) and breast cancer. In PCB-poisoned populations, exposure is associated with overall mortality, mortality from hepatic disease (men), CVD (men and women) and several cancers. PBDEs are adversely associated with children’s cognitive development and IQ loss. PBDEs and certain PFAS are associated with changes in thyroid function. PFAS exposure is associated with increased body mass index (BMI) and overweight in children, attention deficit hyperactive disorder (ADHD) in girls and allergic rhinitis. Potential protective associations were found, namely abnormal pubertal timing in boys being less common with higher phthalate exposure, increased high-density lipoprotein (HDL) with exposure to mono(2-ethyl-5-oxohexyl) phthalate (MEOHP) and reduced incidence of chronic lymphocytic lymphoma (a subtype of NHL) with PCB exposure. Conclusions: Exposure to plastic-associated chemicals is associated with adverse outcomes across a wide range of human health domains, and every plastic-associated chemical group is associated with at least one adverse health outcome. Large gaps remain for many plastic-associated chemicals. Recommendations: For research, we recommend that efforts are harmonised globally to pool resources and extend beyond the chemicals included in this umbrella review. Priorities for primary research, with ensuing systematic reviews, could include micro- and nanoplastics as well as emerging plastic-associated chemicals of concern such as bisphenol analogues and replacement plasticisers and flame retardants. With respect to chemical regulation, we propose that safety for plastic-associated chemicals in humans cannot be assumed at market entry. We therefore recommend that improved independent, systematic hazard testing for all plastic-associated chemicals is undertaken before market release of products. In addition because of the limitations of laboratory-based testing for predicting harm from plastic in humans, independent and systematic post-market bio-monitoring and epidemiological studies are essential to detect potential unforeseen harms.

Zinc hydroxide nitrate (ZHN) was used as an anionic adsorbent for the removal of methyl orange (MO) dye from aqueous solutions. ZHN was characterized via X-ray diffraction (XRD) and infrared spectroscopy (FTIR) techniques. Investigations were carried out to see how the adsorption of MO was affected by factors such as initial MO concentration, contact time and temperature. Adsorption isotherms were analyzed using the Langmuir and Freundlich equations, with the first one being the better result for the equilibrium data. Adsorption kinetics was studied through applying pseudo-first and pseudo-second-order kinetic models, and the experimental data were better fitted to the pseudo-second-order model. The activation energy was determined using the Arrhenius equation to be 105.45 kJ mol−1, revealing the chemical nature of the adsorption process. The thermodynamic parameters were also determined, showing the adsorption of MO onto ZHN to be a non-spontaneous and exothermic process. The experimental results showed ZHN as a potential adsorbent with adsorption capacity for removing anionic dyes from water medium.

El presente artículo de investigación analiza la ética desde los aspectos teóricos y legales en las organizaciones sindicales de Venezuela. Para ello, se consultaron los criterios de prestigiosos doctrinarios y la LOTTT (2012). Se hizo un recorrido por las principales dimensiones éticas donde hacen vida esta clase de organismos especialmente las fundadas en empresas privadas. La metodología aplicada en el presente estudio se sustenta dentro del método cualitativo, se hace igualmente uso del análisis crítico, aplicando la hermenéutica como base de las interpretaciones. Entretanto, se demuestra que existen suficientes elementos, tanto teóricos como legales, para fomentar la conducta ejemplar por parte de estas organizaciones de representación colectiva. Las principales conclusiones están enfocadas en la construcción y transformación del comportamiento ético que deben desplegar las organizaciones sindicales a los fines de cumplir con sus propósitos legales en beneficio de sus agremiados, así mismo, se hace un esbozo del aspecto teórico de la legislación aplicable con el propósito de evidenciar sus interacciones naturales y como subyacen en sus diferentes contextos éticos.

Abstract Background Middle and older years are associated with age related health deficits but how early this begins and progresses is poorly understood. Better understanding is needed to address early decline and support healthier ageing outcomes. Methods Seemingly healthy, community dwelling adults aged 40 to 75 years were recruited via local council and business networks. They completed online surveys about sleep quality, distress and physical activity, and two hours of objective testing of physiologic and anthropometric measures, mobility, cognition, grip strength, foot sensation, dexterity and functional hearing. Analysis compared outcomes for age, gender, and age and gender groups with population norms for 21 health assessments. The total number of non-compliant tests for each participant was calculated by summing the number of non-compliant tests, and the frequency of these scores across the sample was reported. Gender and age effects were tested using ANOVA models. Combined age and gender categories were used for subsequent logistic regression modelling, with females aged 40–49 years being the default comparator. Results Of 561 participants (67% female; mean age 60 years (SD 10.3)), everyone had at least one deficit and median deficits was 5 (IQR 2). More than 50% of participants did not meet anthropometric and exercise norms, while 30 to 40% had reduced functional hearing and cognition. Overall, men performed worse and deficits increased with age particularly for physical activity, audiology, mobility, anthropometry, oximetry and foot sensation. Heart rate, body temperature and dyspnoea were the only variables where compliance was within 95% of expected values. Multiple areas of functional decline were found in people aged in their 40s and 50s. Conclusions The health deficits identified are mostly mutable hence identification and interventions to address the multi-system functional decline in people as young as 40 has the capacity to ensure healthier ageing.

The poly(ethylene terephthalate) (PET) is a thermoplastic polyester, non-degradable in the environment with high resistance to chemical and physical agents. Due to the substantial amount of waste generated and accumulated in the environment, chemical recycling of post-consumer PET has been considered the most successful method for polymer recycling. This work presents results of chemical recycling of post-consumer PET via alkaline hydrolysis and glycolysis. The alkaline hydrolysis is considered the most suitable to the green chemistry and this method can be carried out using mild reaction conditions. The process results in a good yield (97%) to terephthalic acid (TPA). The catalyzed glycolysis of post-consumer PET was carried out in a short reaction time and relatively low temperature, with bis (2-hydroxyethyl) terephthalate (BHET) yield of 75%. TPA and BHET were characterized by FTIR and 1H NMR techniques. The analyses proved to be successful in obtaining both products. Therefore, this work contributes to the chemical recycling studies of PET waste and encourages further studies along this research area. DOI: http://dx.doi.org/10.17807/orbital.v10i3.1104

Nowadays, companies need to make faster decisions, with the support of information technology. Thepresent project, which was applied in the BCP approximately two years ago, consisted in the evaluation and implementation of an agile methodological approach for the development of data warehouse projects, using the Scrum methodology. The work began with a consultancy to identify what improvements and changes would have to be made through a new model of customer service. With the improvement proposals, a pilot was executed to check the effectiveness of the Agile methodology. The benefits were the following: reduction of time to market, reduction of execution time and fulfillment of deadlines in the development stage, availability to attend more requirements, guarantee of the quality of the deliverable due to the constant and active participation of the user, reduction of the risk of error and implementations without value to the business, among other benefits. The model was displayed through the formalization of the process in the organization and an agile governance committee was formed - integrated by the main business managers - to ensure compliance with the model of customer service. As a result of this change, in the project management, the optimization of its costs was achieved.

Schwartz–Jampel syndrome (SJS) is a rare genetic condition that is characterized by several musculoskeletal abnormalities, such as myotonia, joint contractures, and facial dysmorphisms. Patients with this syndrome can present an anesthetic challenge, due to an increased risk of developing malignant hyperthermia (MH) and the possibility of encountering a difficult airway. Several precautions must be taken when general anesthesia is required, such as the avoidance of potential triggers for MH, continuous core temperature, and end-tidal CO2monitoring, assuring that dantrolene is readily available. It is also fundamental to prepare for a possible difficult airway, guaranteeing that difficult airway devices are available. We describe the anesthetic management of a 14-year-old boy diagnosed with SJS who was scheduled for multiple dental extractions and was successfully anesthetized with our approach.

Listeria monocytogenes is an uncommon cause of brain abscesses. Immunocompromised hosts, pregnant women and patients at extremes of age are especially susceptible. We discuss the successful management of a woman with autoimmune hepatitis on prednisone and azathioprine therapy with a L. monocytogenes brain abscess. Previously thought to be a rare cause of central nervous system (CNS) infection, the incidence of CNS listeriosis has increased due to a rise in organ and bone marrow transplantation requiring immunosuppressive medications. L. monocytogenes brain abscesses are now more frequently described and are associated with high rates of concomitant bacteremia suggesting a hematogenous route of infection. Keywords: Listeria monocytogenes, Brain abscess, Autoimmune hepatitis, Azathioprine

Objectives: There are no agreed comprehensive tests for age-related changes to physical, emotional, mental and social functioning. Research into declining function focuses on those 75 years and older and little is known about age-related changes in younger people. The aims of this project were (1) to ascertain a comprehensive test battery that could underpin community-based health screening programmes for people aged 40–75 years and pilot both (2) community-based recruitment and (3) the utility, acceptability, response burden and logistics. Methods: A total of 11 databases were searched using a broad range of relevant terms. An identified comprehensive, recent, high-quality systematic review of screening instruments for detection of early functional decline for community-dwelling older people identified many relevant tools; however, not all body systems were addressed. Therefore, lower hierarchy papers identified in the rapid review were included and expert panel consultation was conducted before the final test battery was agreed. Broad networks were developed in one Australian city to aid pilot recruitment of community-dwellers 40–75 years. Recruitment and testing processes were validated using feasibility testing with 12 volunteers. Results: The test battery captured (1) online self-reports of demographics, health status, sleep quality, distress, diet, physical activity, oral health, frailty and continence; and (2) objective tests of anthropometry; mobility; lung function; dexterity; flexibility, strength and stability; hearing; balance; cognition and memory; foot sensation; and reaction time. Recruitment and testing processes were found to be feasible. Conclusion: This screening approach may provide new knowledge on healthy ageing in younger people.