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5. More than smell – COVID-19 is associated with severe impairment of smell, taste, and chemesthesis

Author

Parma, Valentina, Ohla, Kathrin, Veldhuizen, Maria G, Niv, Masha Y, Kelly, Christine E, Bakke, Alyssa J, Cooper, Keiland W, Bouysset, Cédric, Pirastu, Nicola, Dibattista, Michele, Kaur, Rishemjit, Liuzza, Marco Tullio, Pepino, Marta Y, Schöpf, Veronika, Pereda-Loth, Veronica, Olsson, Shannon B, Gerkin, Richard C, Domínguez, Paloma Rohlfs, Albayay, Javier, Farruggia, Michael C, Bhutani, Surabhi, Fjaeldstad, Alexander W, Kumar, Ritesh, Menini, Anna, Bensafi, Moustafa, Sandell, Mari, Konstantinidis, Iordanis, Di Pizio, Antonella, Genovese, Federica, Öztürk, Lina, Thomas-Danguin, Thierry, Frasnelli, Johannes, Boesveldt, Sanne, Saatci, Özlem, Saraiva, Luis R, Lin, Cailu, Golebiowski, Jérôme, Hwang, Liang-Dar, Ozdener, Mehmet Hakan, Guàrdia, Maria Dolors, Laudamiel, Christophe, Ritchie, Marina, Havlícek, Jan, Pierron, Denis, Roura, Eugeni, Navarro, Marta, Nolden, Alissa A, Lim, Juyun, Whitcroft, KL, Colquitt, Lauren R, Ferdenzi, Camille, Brindha, Evelyn V, Altundag, Aytug, Macchi, Alberto, Nunez-Parra, Alexia, Patel, Zara M, Fiorucci, Sébastien, Philpott, Carl M, Smith, Barry C, Lundström, Johan N, Mucignat, Carla, Parker, Jane K, van den Brink, Mirjam, Schmuker, Michael, Fischmeister, Florian Ph S, Heinbockel, Thomas, Shields, Vonnie DC, Faraji, Farhoud, Santamaría, Enrique, Fredborg, William EA, Morini, Gabriella, Olofsson, Jonas K, Jalessi, Maryam, Karni, Noam, D’Errico, Anna, Alizadeh, Rafieh, Pellegrino, Robert, Meyer, Pablo, Huart, Caroline, Chen, Ben, Soler, Graciela M, Alwashahi, Mohammed K, Welge-Lüssen, Antje, Freiherr, Jessica, de Groot, Jasper HB, Klein, Hadar, Okamoto, Masako, Singh, Preet Bano, Hsieh, Julien W, Reed, Danielle R, Hummel, Thomas, Munger, Steven D, Hayes, John E, Abdulrahman, Olagunju, Dalton, Pamela, Yan, Carol H, Voznessenskaya, Vera V, Chen, Jingguo, Sell, Elizabeth A, and Walsh-Messinger, Julie

Subjects
Neurosciences, Dental/Oral and Craniofacial Disease, Clinical Research, Adult, Aged, Betacoronavirus, COVID-19, Coronavirus Infections, Female, Humans, Male, Middle Aged, Olfaction Disorders, Pandemics, Pneumonia, Viral, SARS-CoV-2, Self Report, Smell, Somatosensory Disorders, Surveys and Questionnaires, Taste, Taste Disorders, Young Adult, head and neck surgery, olfaction, somatosensation, GCCR Group Author, Biological Sciences, Neurology & Neurosurgery
Abstract

Recent anecdotal and scientific reports have provided evidence of a link between COVID-19 and chemosensory impairments, such as anosmia. However, these reports have downplayed or failed to distinguish potential effects on taste, ignored chemesthesis, and generally lacked quantitative measurements. Here, we report the development, implementation, and initial results of a multilingual, international questionnaire to assess self-reported quantity and quality of perception in 3 distinct chemosensory modalities (smell, taste, and chemesthesis) before and during COVID-19. In the first 11 days after questionnaire launch, 4039 participants (2913 women, 1118 men, and 8 others, aged 19-79) reported a COVID-19 diagnosis either via laboratory tests or clinical assessment. Importantly, smell, taste, and chemesthetic function were each significantly reduced compared to their status before the disease. Difference scores (maximum possible change ±100) revealed a mean reduction of smell (-79.7 ± 28.7, mean ± standard deviation), taste (-69.0 ± 32.6), and chemesthetic (-37.3 ± 36.2) function during COVID-19. Qualitative changes in olfactory ability (parosmia and phantosmia) were relatively rare and correlated with smell loss. Importantly, perceived nasal obstruction did not account for smell loss. Furthermore, chemosensory impairments were similar between participants in the laboratory test and clinical assessment groups. These results show that COVID-19-associated chemosensory impairment is not limited to smell but also affects taste and chemesthesis. The multimodal impact of COVID-19 and the lack of perceived nasal obstruction suggest that severe acute respiratory syndrome coronavirus strain 2 (SARS-CoV-2) infection may disrupt sensory-neural mechanisms.

Published
2020

7. List of contributors

Author

Ayed, Charfedinne, primary, Badonnel, Karine, additional, Baly, Christine, additional, Briand, Loïc, additional, Brindisi, Marie-Claude, additional, Brondel, Laurent, additional, Canon, Francis, additional, Croy, Ilona, additional, de Graaf, Kees C., additional, Duchamp-Viret, Patricia, additional, Feron, Gilles, additional, Forde, Ciarán G., additional, Georgiopoulos, Charalampos, additional, Guichard, Elisabeth, additional, Haehner, Antje, additional, Havermans, Remco C., additional, Heydel, Jean-Marie, additional, Hummel, Thomas, additional, Ibarlucea-Jerez, Maria, additional, Jacquin-Piques, Agnès, additional, Köster, Egon P., additional, Kuczewski, Nicola, additional, Licandro, Hélène, additional, Mojet, Jos, additional, Mouillot, Thomas, additional, Mérignac-Lacombe, Jeanne, additional, Neiers, Fabrice, additional, Neyraud, Eric, additional, Nicklaus, Sophie, additional, Pénicaud, Luc, additional, Rolls, Edmund T., additional, Saint-Eve, Anne, additional, Salles, Christian, additional, Schaal, Benoist, additional, Schwartz, Mathieu, additional, Sinding, Charlotte, additional, Stevenson, Richard J., additional, Thomas-Danguin, Thierry, additional, Tournier, Carole, additional, and van den Heuvel, Emmy, additional

Published
2023
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17. Perspectives on Nasal Odorant Metabolism Research

Author

Kornbausch, Nicole, primary, Mérignac-Lacombe, Jeanne, additional, Neiers, Fabrice, additional, Thomas-Danguin, Thierry, additional, Heydel, Jean-Marie, additional, Steinke, Maria, additional, Hackenberg, Stephan, additional, and Loos, Helene M., additional

Published
2023
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19. Smell and taste changes are early indicators of the COVID-19 pandemic and political decision effectiveness

Author

Pierron, Denis, Pereda-Loth, Veronica, Mantel, Marylou, Moranges, Maëlle, Bignon, Emmanuelle, Alva, Omar, Kabous, Julie, Heiske, Margit, Pacalon, Jody, David, Renaud, Dinnella, Caterina, Spinelli, Sara, Monteleone, Erminio, Farruggia, Michael C., Cooper, Keiland W., Sell, Elizabeth A., Thomas-Danguin, Thierry, Bakke, Alyssa J., Parma, Valentina, Hayes, John E., Letellier, Thierry, Ferdenzi, Camille, Golebiowski, Jérôme, and Bensafi, Moustafa

Published
2020
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22. Covid-19 affects taste independent of taste-smell confusions : Results from a combined chemosensory home test and online survey from a large global cohort

Author

Nguyen, Ha, Albayay, Javier, Höchenberger, Richard, Bhutani, Surabhi, Boesveldt, Sanne, Busch, Niko A., Croijmans, Ilja, Cooper, Keiland W., De Groot, Jasper H.B., Farruggia, Michael C., Fjaeldstad, Alexander W., Hayes, John E., Hummel, Thomas, Joseph, Paule V., Laktionova, Tatiana K., Thomas-Danguin, Thierry, Veldhuizen, Maria G., Voznessenskaya, Vera V., Parma, Valentina, Pepino, M.Y., Ohla, Kathrin, Nguyen, Ha, Albayay, Javier, Höchenberger, Richard, Bhutani, Surabhi, Boesveldt, Sanne, Busch, Niko A., Croijmans, Ilja, Cooper, Keiland W., De Groot, Jasper H.B., Farruggia, Michael C., Fjaeldstad, Alexander W., Hayes, John E., Hummel, Thomas, Joseph, Paule V., Laktionova, Tatiana K., Thomas-Danguin, Thierry, Veldhuizen, Maria G., Voznessenskaya, Vera V., Parma, Valentina, Pepino, M.Y., and Ohla, Kathrin

Abstract

People often confuse smell loss with taste loss, so it is unclear how much gustatory function is reduced in patients self-reporting taste loss. Our pre-registered cross-sectional study design included an online survey in 12 languages with instructions for self-Administering chemosensory tests with 10 household items. Between June 2020 and March 2021, 10,953 individuals participated. Of these, 5,225 self-reported a respiratory illness and were grouped based on their reported COVID test results: COVID-positive (COVID+, N = 3,356), COVID-negative (COVID-, N = 602), and COVID unknown for those waiting for a test result (COVID?, N = 1,267). The participants who reported no respiratory illness were grouped by symptoms: sudden smell/taste changes (STC, N = 4,445), other symptoms excluding smell or taste changes (OthS, N = 832), and no symptoms (NoS, N = 416). Taste, smell, and oral irritation intensities and self-Assessed abilities were rated on visual analog scales. Compared to the NoS group, COVID+ was associated with a 21% reduction in taste (95% confidence interval (CI): 15-28%), 47% in smell (95% CI: 37-56%), and 17% in oral irritation (95% CI: 10-25%) intensity. There were medium to strong correlations between perceived intensities and self-reported abilities (r = 0.84 for smell, r = 0.68 for taste, and r = 0.37 for oral irritation). Our study demonstrates that COVID-19-positive individuals report taste dysfunction when self-Tested with stimuli that have little to none olfactory components. Assessing the smell and taste intensity of household items is a promising, cost-effective screening tool that complements self-reports and may help to disentangle taste loss from smell loss. However, it does not replace standardized validated psychophysical tests.

Published
2023

23. Ranking task versus intensity scales, what is the best method to evaluate odor‐induced taste enhancement?

Author

Aveline, Christopher, Thomas‐Danguin, Thierry, and Sinding, Charlotte

Subjects
*APPLE juice, *TASTE perception, *VISUAL analog scale
Abstract

Odorants in food or beverages might enhance the taste. This phenomenon is called Odor‐Induced Taste Enhancement (OITE). OITE has been shown using taste‐intensity visual analog scales (VAS). VAS is often criticized because it is prone to halo‐dumping effects. We compared VAS and ranking methods to evaluate OITE in people living with normal‐weight or obesity. Sweet apple juice and salty green‐pea soup were spiked with either vanillin or bacon odorants to produce OITE. In the VAS experiment, saltiness, sweetness, sourness, bitterness and the global aroma intensities were evaluated for each base with and without the odorants. The ranking task consisted in ranking from the lowest to the highest sweetness/saltiness intensities, three references with increasing tastant concentration and a target solution with the lowest tastant concentration and the odorant. VAS highlighted OITE neither in the apple juice nor in the green‐pea soup, in no group. The ranking method revealed an OITE in the green‐pea soup in both groups, and only the group with obesity experienced OITE in the apple juice. Practical Applications: The ranking task appears as an optimal method to highlight OITE and is sufficiently sensitive to demonstrate subtle differences related to participants' weight status. The ranking task is easy to perform, does not require training and does not imply a high number of participants to be statistically powered. Odor‐Induced Taste Enhancement is a strategy that might be employed to significantly reduce salt, and sugar, while maintaining an acceptable taste intensity, at home as well as in food formulation by the industry. [ABSTRACT FROM AUTHOR]

Published
2023
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24. Covid-19 affects taste independently of smell: results from a combined chemosensory home test and online survey from a global cohort (N=10,953)

Author

Nguyen, Ha, primary, Albayay, Javier, additional, Höchenberger, Richard, additional, Bhutani, Surabhi, additional, Boesveldt, Sanne, additional, Busch, Niko A., additional, Croijmans, Ilja, additional, Cooper, Keiland W., additional, de Groot, Jasper H. B., additional, Farruggia, Michael C., additional, Fjaeldstad, Alexander W., additional, Hayes, John E., additional, Hummel, Thomas, additional, Joseph, Paule V., additional, Laktionova, Tatiana K., additional, Thomas-Danguin, Thierry, additional, Veldhuizen, Maria G., additional, Voznessenskaya, Vera V., additional, Parma, Valentina, additional, Pepino, M. Yanina, additional, and Ohla, Kathrin, additional

Published
2023
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26. Covid-19 affects taste independent of taste–smell confusions: results from a combined chemosensory home test and online survey from a large global cohort

Author

Nguyen, Ha, primary, Albayay, Javier, additional, Höchenberger, Richard, additional, Bhutani, Surabhi, additional, Boesveldt, Sanne, additional, Busch, Niko A, additional, Croijmans, Ilja, additional, Cooper, Keiland W, additional, de Groot, Jasper H B, additional, Farruggia, Michael C, additional, Fjaeldstad, Alexander W, additional, Hayes, John E, additional, Hummel, Thomas, additional, Joseph, Paule V, additional, Laktionova, Tatiana K, additional, Thomas-Danguin, Thierry, additional, Veldhuizen, Maria G, additional, Voznessenskaya, Vera V, additional, Parma, Valentina, additional, Pepino, M Yanina, additional, and Ohla, Kathrin, additional

Published
2023
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29. Multidisciplinary approach to explore interactions in odor mixture perception

Author

Thomas-Danguin, Thierry, Le Bon, Anne-Marie, Taboureau, Olivier, Koensgen, Florian, Jarriault, David, Datiche, Frédérique, Aveline, Christopher, Béno, Noëlle, Rugard, Marylène, Audouze, Karine, Soubeyre, Vanessa, Bouchez, Olivier, Klopp, Christophe, Guichard, Elisabeth, Sinding, Charlotte, Tromelin, Anne, Julien, Sabine, and APPEL À PROJETS GÉNÉRIQUE 2018 - Approche multidisciplinaire pour mieux comprendre la première étape de la perception des arômes en mélange. - - MULTIMIX2018 - ANR-18-CE21-0006 - AAPG2018 - VALID

Subjects
[SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology
Abstract

Odors and aromas perceived in food and in the environment result from the processing of complex chemical mixtures of volatile compounds that should be efficiently processed by the olfactory system. It is known for decades that this processing generates perceptual interactions, such as masking, synergy, or perceptual blending, which contribute to elaborating a synthetic brain representation of the chemical information. Nevertheless, the perceptual processes underlying these interactions are still poorly known. In this project, we set out a multidisciplinary approach to identify the characteristics of odorants and olfactory receptors (ORs) that could support perceptual interactions. We hypothesized that odorants involved in interactions at the peripheral level should share common structural characteristics to allow the activation of a common set of ORs. First, using an RNA-seq approach in mice, we identified the ORs responding to either single odorants or mixtures exhibiting specific perceptual interactions. Then, we confirmed that the target ORs responded to odorants in an in vitro cellular system and that the expected perceptual interactions occurred between the odorants at the olfactory periphery, through EOG recordings on mice’s olfactory mucosa, but also through sensory evaluation in humans. Additionally, a computational study revealed common molecular features between the odorants involved in interactions. When combined, all the results highlight that perceptual interactions such as masking could rise from competition between odorants at the OR level, but that other interactions such as perceptual blending most likely originate from more central integrative brain processing.

Published
2023

34. Exploring the odorant and molecular characteristics of molecules sharing the odour notes of an aroma blending mixture

Author

Tromelin, Anne, Koensgen, Florian, Rugard, Marylène, Audouze, Karine, Thomas-Danguin, Thierry, and Guichard, Élisabeth

Subjects
pharmacophore, aroma blending mixture, odour note
Abstract

The human olfactory system allows to perceive and identify a huge number of odours from few hundreds ORs involved in an olfactory coding whereby one olfactory receptor (OR) recognises multiple odorants while one odorant activates different combinations of ORs. Odours perceived in our environment are mainly the result of mixtures of odorants, but the specific mechanisms involved in their processing remain poorly understood. In previous studies performed at INRAE-CSGA, the perception of a binary mixture of ethyl isobutyrate (Et iB, strawberry-like odour, STR) and ethyl maltol (Et-M, caramel-like odour, CAR) was investigated in comparison with a reference (allyl hexanoate, Al-H, pineapple-like odour, PNA). In humans, the binary specific mixture of Et-iB and Et-M was judged as more typical of a pineapple odour than the individual components, and similar to those of allyl hexanoate. The analysis of the network of odours sharing by 293 molecules described with at least one of the odours STR, CAR or PNA revealed peculiar links between odours, and led to identify 9 STR-CAR and 4 STR-PNA molecules. We investigated the molecular features of these molecules by performing pharmacophore generations using the STR-CAR, STR-PNA sets, both separately and putting together the 13 molecules. Comparing the distances between features of the three models revealed a common distance close to 8 Å between the centres of at least one HY and one HBA. Additionally, the pharmacophore comparison of the three models showed a satisfactory mapping of the features. These results support the hypothesis wherewith molecules sharing the odours involved in a blending mixture could recognise a common set of ORs.

Published
2022
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35. A follow-up on quantitative and qualitative olfactory dysfunction and other symptoms in patients recovering from COVID-19 smell loss

Author

Ohla, Kathrin, Veldhuizen, Maria G., Green, Tomer, Hannum, Mackenzie E., Bakke, Alyssa J., Moein, Shima T., Tognetti, Arnaud, Postma, Elbrich M., Pellegrino, Robert, Hwang, Daniel Liang Dar, Albayay, Javier, Koyama, Sachiko, Nolden, Alissa A., Thomas-Danguin, Thierry, Mucignat-Caretta, Carla, Menger, Nick S., Croijmans, Ilja, Öztürk, Lina, Yanık, Hüseyin, Pierron, Denis, Pereda-Loth, Veronica, Nunez-Parra, Alexia, Martinez Pineda, Aldair M., Gillespie, David, Farruggia, Michael C., Cecchetto, Cinzia, Fornazieri, Marco A., Philpott, Carl, Voznessenskaya, Vera, Cooper, Keiland W., Dominguez, Paloma Rohlfs, Calcinoni, Orietta, de Groot, Jasper, Boesveldt, Sanne, Bhutani, Surabhi, Weir, Elisabeth M., Exten, Cara, Joseph, Paule V., Parma, Valentina, Hayes, John E., Niv, Masha Y., Ohla, Kathrin, Veldhuizen, Maria G., Green, Tomer, Hannum, Mackenzie E., Bakke, Alyssa J., Moein, Shima T., Tognetti, Arnaud, Postma, Elbrich M., Pellegrino, Robert, Hwang, Daniel Liang Dar, Albayay, Javier, Koyama, Sachiko, Nolden, Alissa A., Thomas-Danguin, Thierry, Mucignat-Caretta, Carla, Menger, Nick S., Croijmans, Ilja, Öztürk, Lina, Yanık, Hüseyin, Pierron, Denis, Pereda-Loth, Veronica, Nunez-Parra, Alexia, Martinez Pineda, Aldair M., Gillespie, David, Farruggia, Michael C., Cecchetto, Cinzia, Fornazieri, Marco A., Philpott, Carl, Voznessenskaya, Vera, Cooper, Keiland W., Dominguez, Paloma Rohlfs, Calcinoni, Orietta, de Groot, Jasper, Boesveldt, Sanne, Bhutani, Surabhi, Weir, Elisabeth M., Exten, Cara, Joseph, Paule V., Parma, Valentina, Hayes, John E., and Niv, Masha Y.

Abstract

Background: Sudden smell loss is a specific early symptom of COVID-19, which, prior to the emergence of Omicron, had estimated prevalence of ~40% to 75%. Chemosensory impairments affect physical and mental health, and dietary behavior. Thus, it is critical to understand the rate and time course of smell recovery. The aim of this cohort study was to characterize smell function and recovery up to 11 months post COVID-19 infection. Methods: This longitudinal survey of individuals suffering COVID-19-related smell loss assessed disease symptoms and gustatory and olfactory function. Participants (n=12,313) who completed an initial survey (S1) about respiratory symptoms, chemosensory function and COVID-19 diagnosis between April and September 2020, were invited to complete a follow-up survey (S2). Between September 2020 and February 2021, 27.5% participants responded (n=3,386), with 1,468 being diagnosed with COVID-19 and suffering co-occurring smell and taste loss at the beginning of their illness. Results: At follow-up (median time since COVID-19 onset ~200 days), ~60% of women and ~48% of men reported less than 80% of their pre-illness smell ability. Taste typically recovered faster than smell, and taste loss rarely persisted if smell recovered. Prevalence of parosmia and phantosmia was ~10% of participants in S1 and increased substantially in S2: ~47% for parosmia and ~25% for phantosmia. Persistent smell impairment was associated with more symptoms overall, suggesting it may be a key marker of long-COVID illness. The ability to smell during COVID-19 was rated slightly lower by those who did not eventually recover their pre-illness ability to smell at S2. Conclusions: While smell ability improves for many individuals who lost it during acute COVID-19, the prevalence of parosmia and phantosmia increases substantially over time. Olfactory dysfunction is associated with broader persistent symptoms of COVID-19, and may last for many months following acute COVID-19. Taste l

Published
2022

38. Multimodal interactions

Author

Thomas-Danguin, Thierry, primary, Sinding, Charlotte, additional, Tournier, Carole, additional, and Saint-Eve, Anne, additional

Published
2016
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39. List of Contributors

Author

Antti, Knaapila, primary, Aydınoğlu, Nilüfer Z., additional, Baly, Christine, additional, Briand, Loïc, additional, Brindisi, Marie-Claude, additional, Brondel, Laurent, additional, Croy, Ilona, additional, Duchamp-Viret, Patricia, additional, Forde, Ciarán G., additional, Guichard, Elisabeth, additional, Haehner, Antje, additional, Havermans, Remco C., additional, Hummel, Thomas, additional, Jacquin-Piques, Agnès, additional, Köster, E.P., additional, Kuszewski, Nicola, additional, Lacroix, Marie-Christine, additional, Mari, Sandell, additional, Mojet, J., additional, Mouillot, Thomas, additional, Nicklaus, Sophie, additional, Oskar, Laaksonen, additional, Pénicaud, Luc, additional, Rolls, Edmund T., additional, Saint-Eve, Anne, additional, Salles, Christian, additional, Sayın, Eda, additional, Schaal, Benoist, additional, Sinding, Charlotte, additional, Stevenson, Richard J., additional, Thomas-Danguin, Thierry, additional, Tournier, Carole, additional, Tromelin, Anne, additional, Ulla, Hoppu, additional, and Valentin, Dominique, additional

Published
2016
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40. Mere end lugtesans - COVID-19 er associeret med svær påvirkning af lugtesansen, smagssansen og mundfølelsen

Author

Parma, Valentina, Ohla, Kathrin, Veldhuizen, Maria G, Niv, Masha Y, Kelly, Christine E, Bakke, Alyssa J, Cooper, Keiland W, Bouysset, Cédric, Pirastu, Nicola, Dibattista, Michele, Kaur, Rishemjit, Liuzza, Marco Tullio, Pepino, Marta Y, Schöpf, Veronika, Pereda-Loth, Veronica, Olsson, Shannon B, Gerkin, Richard C, Rohlfs Domínguez, Paloma, Albayay, Javier, Farruggia, Michael C, Bhutani, Surabhi, Fjaeldstad, Alexander W, Kumar, Ritesh, Menini, Anna, Bensafi, Moustafa, Sandell, Mari, Konstantinidis, Iordanis, Di Pizio, Antonella, Genovese, Federica, Öztürk, Lina, Thomas-Danguin, Thierry, Frasnelli, Johannes, Boesveldt, Sanne, Saatci, Özlem, Saraiva, Luis R, Lin, Cailu, Golebiowski, Jérôme, Hwang, Liang-Dar, Ozdener, Mehmet Hakan, Guàrdia, Maria Dolors, Laudamiel, Christophe, Ritchie, Marina, Havlícek, Jan, Pierron, Denis, Roura, Eugeni, Navarro, Marta, Nolden, Alissa A, Lim, Juyun, Whitcroft, Katherine L, Colquitt, Lauren R, Ferdenzi, Camille, Brindha, Evelyn V, Altundag, Aytug, Macchi, Alberto, Nunez-Parra, Alexia, Patel, Zara M, Fiorucci, Sébastien, Philpott, Carl M, Smith, Barry C, Lundström, Johan N, Mucignat, Carla, Parker, Jane K, van den Brink, Mirjam, Schmuker, Michael, Fischmeister, Florian Ph S, Heinbockel, Thomas, Shields, Vonnie D C, Faraji, Farhoud, Santamaría, Enrique, Fredborg, William E A, Morini, Gabriella, Olofsson, Jonas K, Jalessi, Maryam, Karni, Noam, D’Errico, Anna, Alizadeh, Rafieh, Pellegrino, Robert, Meyer, Pablo, Huart, Caroline, Chen, Ben, Soler, Graciela M, Alwashahi, Mohammed K, Welge-Lüssen, Antje, Freiherr, Jessica, de Groot, Jasper H B, Klein, Hadar, Okamoto, Masako, Singh, Preet Bano, Hsieh, Julien W, Abdulrahman, Olagunju, Dalton, Pamela, Yan, Carol H, Voznessenskaya, Vera V, Chen, Jingguo, Sell, Elizabeth A, Walsh-Messinger, Julie, Archer, Nicholas S, Koyama, Sachiko, Deary, Vincent, Roberts, S Craig, Yanık, Hüseyin, Albayrak, Samet, Nováková, Lenka Martinec, Croijmans, Ilja, Mazal, Patricia Portillo, Moein, Shima T, Margulis, Eitan, Mignot, Coralie, Mariño, Sajidxa, Georgiev, Dejan, Kaushik, Pavan K, Malnic, Bettina, Wang, Hong, Seyed-Allaei, Shima, Yoluk, Nur, Razzaghi-Asl, Sara, Justice, Jeb M, Restrepo, Diego, Reed, Danielle R, Hummel, Thomas, Munger, Steven D, Hayes, John E, Indústries Alimentàries, Qualitat i Tecnologia Alimentària, Tecnologia Alimentària, Temple University [Philadelphia], Pennsylvania Commonwealth System of Higher Education (PCSHE), Forschungszentrum Jülich GmbH | Centre de recherche de Juliers, Helmholtz-Gemeinschaft = Helmholtz Association, Mersin University, The Hebrew University of Jerusalem (HUJ), AbScent, Pennsylvania State University (Penn State), Penn State System, University of California [Irvine] (UC Irvine), University of California (UC), Université Côte d'Azur (UCA), University of Edinburgh, Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro (UNIBA), Central Scientific Instruments Organisation (CSIR), Università degli Studi 'Magna Graecia' di Catanzaro = University of Catanzaro (UMG), University of Illinois at Urbana-Champaign [Urbana], University of Illinois System, Medizinische Universität Wien = Medical University of Vienna, Groupement scientifique de Biologie et de Medecine Spatiale (GSBMS), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National d'Études Spatiales [Toulouse] (CNES), Tata Institute for Fundamental Research (TIFR), Arizona State University [Tempe] (ASU), Universidad de Extremadura - University of Extremadura (UEX), Università degli Studi di Padova = University of Padua (Unipd), Yale School of Medicine [New Haven, Connecticut] (YSM), San Diego State University (SDSU), Aarhus University [Aarhus], University of Hertfordshire [Hatfield] (UH), Scuola Internazionale Superiore di Studi Avanzati / International School for Advanced Studies (SISSA / ISAS), Neurosciences Sensorielles Comportement Cognition, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Helsingin yliopisto = Helsingfors universitet = University of Helsinki, University of Turku, Aristotle University of Thessaloniki, Leibniz-Institute for Food Systems Biology at the Technical University of Munich, Monell Chemical Senses Center, Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Bourgogne Franche-Comté [COMUE] (UBFC), Université de Montréal (UdeM), Wageningen University and Research Centre (WUR), Medical Science University, Sidra Medicine [Doha, Qatar], Institut de Chimie de Nice (ICN), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), University of Southern Queensland (USQ), Institut de Recerca i Tecnologia Agroalimentàries = Institute of Agrifood Research and Technology (IRTA), DreamAir Llc, Charles University [Prague] (CU), Anthropologie Moléculaire et Imagerie de Synthèse (AMIS), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), University of Massachusetts System (UMASS), Oregon State University (OSU), Ear Institute, UCL, Lyon Neuroscience Research center, Karunya University, Biruni University, Assi Sette Llaghi Varese, Stanford School of Medicine [Stanford], Stanford Medicine, Stanford University-Stanford University, University of East Anglia [Norwich] (UEA), California Department of Food and Agriculture (CDFA), Unité mixte de recherche interactions plantes-microorganismes, Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Maastricht University [Maastricht], Institute for Biology - Neurobiology, Freie Universität Berlin, Karl-Franzens-Universität Graz, Howard University College of Medicine, Towson University, University of California [San Diego] (UC San Diego), Proteomics, Center for Applied Medical Research (CIMA), Stockholm University, University of Gastronomic Sciences, Iran University of Medical Sciences, Goethe Universität Frankfurt, University of Tennessee, IBM T.J. Watson Research Center, Université libre de Bruxelles (ULB), Guangzhou Medical University, Buenos Aires University and GEOG (Grupo de Estudio de Olfato y Gusto), Sultan Qaboos University (SQU), Federal University of Technology of Akure (FUTA), A.N. Severtsov Institute of Ecology and Evolution, Russian Academy of Sciences [Moscow] (RAS), Hospital of Xi'an Jiaotong University, University of Pennsylvania, University of Dayton, CSIRO Agriculture and Food (CSIRO), Indiana University [Bloomington], Indiana University System, University of Northumbria at Newcastle [United Kingdom], University of Stirling, Middle East Technical University [Ankara] (METU), Utrecht University [Utrecht], Instituto Universitario del Hospital Italiano [Buenos Aires, Argentina], Institute for Research in Fundamental Sciences [Tehran] (IPM), Hebrew University of Jerusalem, Technische Universität Dresden = Dresden University of Technology (TU Dresden), Terrazas del Club Hipico, University Medical Centre Ljubljana [Ljubljana, Slovenia] (UMCL), Tata Institute of Fundamental Research [Bangalore], Universidade de São Paulo = University of São Paulo (USP), University of Florida [Gainesville] (UF), University of Colorado Anschutz [Aurora], Center for Smell and Taste, Department of Food Science, Pennsylvania State University., Julien, Sabine, Tıp Fakültesi, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service d'oto-rhino-laryngologie, Department of Food and Nutrition, Senses and Food, Research Center Jülich, University of California [Irvine] (UCI), University of California, Università degli studi di Bari Aldo Moro (UNIBA), Università degli Studi 'Magna Graecia' di Catanzaro [Catanzaro, Italie] (UMG), University of Extremadura, University of Padova, Yale University School of Medicine, Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, University of Helsinki, Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Institute of Agrifood Research and Technology (IRTA), Universita degli Studi di Padova, Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Karl-Franzens-Universität [Graz, Autriche], University of California San Diego Health, University of Brussels, University of Pennsylvania [Philadelphia], Tata Institute of Fundamental Research, University of São Paulo (USP), UCL - SSS/IONS - Institute of NeuroScience, FSE Campus Venlo, and RS: FSE UCV

Subjects
Male, Taste, Physiology, Smagstab, Audiology, AcademicSubjects/SCI01180, Settore BIO/09 - Fisiologia, Behavioral Neuroscience, chemistry.chemical_compound, Olfaction Disorders, Taste Disorders, 0302 clinical medicine, RATINGS, Hyposmia, Surveys and Questionnaires, CHEMOSENSITIVITY, [SDV.IDA]Life Sciences [q-bio]/Food engineering, Viral, PALADAR, 030223 otorhinolaryngology, Sensory Science and Eating Behaviour, media_common, TASTE, US NATIONAL-HEALTH, [SDV.IDA] Life Sciences [q-bio]/Food engineering, Middle Aged, Biological Sciences, 16. Peace & justice, Sensory Systems, 3. Good health, Smell, GCCR Group Author, ddc:540, Smell loss, Female, Original Article, medicine.symptom, Corrigendum, Coronavirus Infections, olfaction, Adult, somatosensation, medicine.medical_specialty, 663/664, Coronavirus disease 2019 (COVID-19), OLFACTORY DISORDERS, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), media_common.quotation_subject, Pneumonia, Viral, head and neck surgery, Aged, Betacoronavirus, COVID-19, Humans, Pandemics, SARS-CoV-2, Self Report, Somatosensory Disorders, Young Adult, Anosmia, Sensory system, Olfaction, 03 medical and health sciences, Chemesthesis, Physiology (medical), Perception, medicine, Neurology & Neurosurgery, Behaviour Change and Well-being, business.industry, R-PACKAGE, 3112 Neurosciences, Pneumonia, Parosmia, COMPONENT, Smagssans, [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, Sensoriek en eetgedrag, chemistry, Lugtetab, business, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, 030217 neurology & neurosurgery, Lugtesans
Abstract

Correction: Chemical Senses, Volume 46, 2021, bjab050, https://doi.org/10.1093/chemse/bjab050 Published: 08 December 2021 Recent anecdotal and scientific reports have provided evidence of a link between COVID-19 and chemosensory impairments, such as anosmia. However, these reports have downplayed or failed to distinguish potential effects on taste, ignored chemesthesis, and generally lacked quantitative measurements. Here, we report the development, implementation, and initial results of a multilingual, international questionnaire to assess self-reported quantity and quality of perception in 3 distinct chemosensory modalities (smell, taste, and chemesthesis) before and during COVID-19. In the first 11 days after questionnaire launch, 4039 participants (2913 women, 1118 men, and 8 others, aged 19-79) reported a COVID-19 diagnosis either via laboratory tests or clinical assessment. Importantly, smell, taste, and chemesthetic function were each significantly reduced compared to their status before the disease. Difference scores (maximum possible change +/- 100) revealed a mean reduction of smell (-79.7 +/- 28.7, mean +/- standard deviation), taste (-69.0 +/- 32.6), and chemesthetic (-37.3 +/- 36.2) function during COVID-19. Qualitative changes in olfactory ability (parosmia and phantosmia) were relatively rare and correlated with smell loss. Importantly, perceived nasal obstruction did not account for smell loss. Furthermore, chemosensory impairments were similar between participants in the laboratory test and clinical assessment groups. These results show that COVID-19-associated chemosensory impairment is not limited to smell but also affects taste and chemesthesis.The multimodal impact of COVID-19 and the lack of perceived nasal obstruction suggest that severe acute respiratory syndrome coronavirus strain 2 (SARS-CoV-2) infection may disrupt sensory-neural mechanisms.

Published
2020

41. [P32] Study of Odorants Sharing the Odor Notes of an Aroma Blending Mixture by a Pharmacophore Approach

Author

Tromelin, Anne, Koensgen, Florian, Rugard, Marylène, Audouze, Karine, Thomas-Danguin, Thierry, Guichard, Elisabeth, Julien, Sabine, and APPEL À PROJETS GÉNÉRIQUE 2018 - Approche multidisciplinaire pour mieux comprendre la première étape de la perception des arômes en mélange. - - MULTIMIX2018 - ANR-18-CE21-0006 - AAPG2018 - VALID

Subjects
[CHIM.CHEM] Chemical Sciences/Cheminformatics, [CHIM.ORGA] Chemical Sciences/Organic chemistry
Abstract

Odors perceived in our environment are mainly the result of mixtures of odorants whose the specific mechanisms involved in their processing remain poorly understood [1]. In previous studies performed at INRAE-CSGA [2], the perception of a mixture of ethyl isobutyrate (Et-iB, strawberry-like odor, STR) and ethyl maltol (Et-M, caramel-like odor, CAR) was investigated in comparison with a reference (allyl hexanoate, Al-H, pineapple-like odor, PNA) chosen to evoke an odor close to the one expected in the mixture. The binary specific mixture of Et-iB and Et-M was judged as more typical of a pineapple odor than the individual components. Some studies highlight the significance of the biological function of odorant, that is to say their odor, to understand odorant discrimination [3, 4]. From this perspective, we selected molecules having two of the three odors STR, CAR or PNA from the large odorants database that we recently used to perform a multivariate statistical analysis [5]. The pharmacophore generation were performed separately using 9 molecules STR-CAR on the one hand, and 4 molecules STR-PNA on the second hand. We used Common Feature Pharmacophore Generation protocol (Discovery Studio 4.5, Biovia) to generate pharmacophore hypotheses [6]; the maximum number of generated hypotheses for each run was set to 10. In our study, the pharmacophoric features considered are hydrogen bond acceptors (HBA/HBA-lip) and hydrophobic regions (HY/HY-Al). All the hypotheses generated from both the STR-CAR and the STR-PNA sets are made up of 2 HBA/HBA-lip. Besides, STR-CAR hypotheses have only 1 HY/HY-Al while there are 2 for STRPNA hypotheses. We compared the best significant hypotheses generated from STR-CAR and STRPNA. A distance close to 8 Å between the centers of at least one HY and one HBA is common to STR-CAR and STR-PNA models. The pharmacophore comparison of the two models revealed a satisfactory mapping of the features. The obtained result is in line with the scheme of olfactory coding, and is consistent with the hypothesis that molecules sharing the odors involved in a blending mixture could recognize a common set of ORs.

Published
2022

42. Odour-Induced Taste Enhancement in normal-weight and obese people

Author

Aveline, Christopher, Leroy, Cécile, Thomas-Danguin, Thierry, and Sinding, Charlotte

Subjects
ranking task, flavour, OITE, perception, food, obesity, salty, sweet
Abstract

The Odour-Induced Taste Enhancement (OITE) phenomenon allows, by addition of odorants in food or beverages, to enhance the perception of taste. To the best of our knowledge, only Proserpio et al. [1] studied OITE in obese people. Interestingly, in this study, the addition of butter aroma in custard dessert produced OITE only in obese and not in normal-weight people. Here we extended this result by comparing Odour-Induced Sweetness and Saltiness Enhancement in normal-weight and obese peoples using a ranking task on beverages. Forty-three normal weight (NW: 20< BMI< 25kg/m²) and 28 obese participants (OB: BMI> 30kg/m²) took part in the sensory evaluation of 2 sweet solutions and 2 salty solutions. The sweet base solutions were apple juice (Aj) and water and the added odorant was vanillin. The salty base solutions were a green-pea soup and water and the added odorant was a bacon aroma. For the ranking task, three additional solutions with increasing concentrations of either sucrose or sodium chloride (S1 to S3) were prepared for each base. Each solution was tested in a dedicated ranking trial. Subjects received four bottles in a given trial, the three sweet or salty concentrations of the base solution (e.g. AjS1, AjS2, and AjS3) and one of the odorant-added solutions (e.g. AjS1+vanillin). Participants had to rank the 4 bottles according to sweetness or saltiness intensity. The results showed that OITE occurred for all the solutions but differently according to the group and the complexity of the beverage base. In the sweet complex beverage (Aj), only OB perceived a sweet taste enhancement whereas in the green-pea soup OB and NW perceived a salty taste enhancement. OB and NW participants ranked the water-based solutions in a similar way, independently of taste, but with a lower effect size compared with the complex solutions. The highest OITE was observed for the sweet Aj+vanillin and the salty Wsa+bacon samples (sweetness and saltiness increased by at least 50% and 75%, respectively) in OB. To conclude, we showed that the OITE phenomenon significantly differed between NW and OB. Only OB experienced OITE in the sweet complex beverage, while OB and NW experienced OITE in the salty soup. Both groups experienced OITE in the sweet water solutions but with a lower effect size compared with the complex solution (Aj). Our results also demonstrated that the ranking task is efficient to assess OITE and to highlight OITE differences between groups and solutions.

Published
2021
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43. Prediction of sweetness potency from sweet taste receptor dose-response curves

Author

Maillard, Gaïa, Belloir, Christine, Béno, Noëlle, Jeannin, Mathilde, Arnoult, Véronique, Le Bourgot, Cindy, Briand, Loïc, Thomas-Danguin, Thierry, Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Bourgogne Franche-Comté [COMUE] (UBFC), Danone Nutricial Research, Tereos R&D, and Julien, Sabine

Subjects
EC50, [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, sweetness potency, [SDV.IDA]Life Sciences [q-bio]/Food engineering, [SDV.IDA] Life Sciences [q-bio]/Food engineering, sweeteners, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2021

44. Mammalian Olfactory Receptors

Author

Persuy, Marie-Annick, primary, Sanz, Guenhaël, additional, Tromelin, Anne, additional, Thomas-Danguin, Thierry, additional, Gibrat, Jean-François, additional, and Pajot-Augy, Edith, additional

Published
2015
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46. Fat-salty sensory interactions in model cheeses: multivariate analysis of a compilation of data from different projects organised in the BaGaTeL database

Author

Guichard, Elisabeth, Thomas-Danguin, Thierry, Guillemin, Hervé, Perret, Bruno, Buchin, Solange, Pénicaud, Caroline, and Salles, Christian

Subjects
database, dairy product, rheological properties, sensory analysis, statistical analyses
Abstract

The food industry needs to develop new strategies to formulate well-balanced products in terms of nutritional and environmental requirements and sensory acceptability by consumers. The BaGaTeL database has been built, guided by a process and observation ontology in food science, PO² ontology, to integrate data on dairy foods composition process, nutritional and sensory properties, using a consensual model and a shared structured vocabulary. We searched the database, using specific queries, for samples for which data of composition, rheological properties and sensory profile analysis were available. However, the composition and structure of the dairy products and the measured variables are often very different, which do not allow a direct comparison of the data. Thus, we made a selection of 68 model cheeses from 6 different projects made with different compositions (fat, protein, minerals, and water). A principal component analysis (PCA) performed on this set of samples revealed that the sensory hardness was better explained by a low moisture-in-non-fat-content than by a high protein content as was often suggested and that the intensity of salty taste was not only linked to salt content but was also modulated by cheese composition. Considering a subgroup of 22 samples from 3 projects, in which fat perception was also measured, a partial least square analysis revealed that fat perception was not only explained by fat content but was also highly influenced by salty taste, and that salty taste was more correlated with fat perception than with sodium ions content, highlighting sensory fat-salty interactions.

Published
2021
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48. Increasing incidence of parosmia and phantosmia in patients recovering from COVID-19 smell loss

Author

Ohla, Kathrin, primary, Veldhuizen, Maria Geraldine, additional, Green, Tomer, additional, Hannum, Mackenzie E., additional, Bakke, Alyssa J., additional, Moein, Shima T., additional, Tognetti, Arnaud, additional, Postma, Elbrich M., additional, Pellegrino, Robert, additional, Hwang, Liang-Dar, additional, Albayay, Javier, additional, Koyama, Sachiko, additional, Nolden, Alissa, additional, Thomas-Danguin, Thierry, additional, Mucignat-Caretta, Carla, additional, Menger, Nick S., additional, Croijmans, Ilja, additional, Öztürk, Lina, additional, Yanık, Hüseyin, additional, Pierron, Denis, additional, Pereda-Loth, Veronica, additional, Nunez-Parra, Alexia, additional, Pineda, Aldair M. Martinez, additional, Gillespie, David, additional, Farruggia, Michael C., additional, Cecchetto, Cinzia, additional, Fornazieri, Marco A., additional, Philpott, Carl, additional, Voznessenskaya, Vera, additional, Cooper, Keiland, additional, Dominguez, Paloma Rohlfs, additional, Calcinoni, Orietta, additional, de Groot, Jasper, additional, Boesveldt, Sanne, additional, Bhutani, Surabhi, additional, Weir, Elisabeth M., additional, Exten, Cara, additional, Joseph, Paule V., additional, Parma, Valentina, additional, Hayes, John E., additional, and Niv, Masha Y., additional

Published
2021
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49. Perceptual Interactions in Complex Odor Mixtures

Author

Sinding, Charlotte, primary, Coureaud, Gérard, additional, Chabanet, Claire, additional, Chambault, Adeline, additional, Béno, Noelle, additional, Dosne, Thibaut, additional, Schaal, Benoist, additional, and Thomas-Danguin, Thierry, additional

Published
2014
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50. List of Contributors

Author

Acree, Terry E., primary, Aguera, Evelyne, additional, Ahola, Johanna K., additional, Almstätter, Isabella, additional, Alves, Andréa A.R., additional, Amigo, José M., additional, Amrein, Thomas M., additional, Andriot, Isabelle, additional, Antonczak, Serge, additional, Asma, Renske, additional, Athes, Violaine, additional, Aubin, Elodie, additional, Audebert, Alain, additional, Béno, Noelle, additional, Baggenstoss, Juerg, additional, Baiamonte, Irene, additional, Baines, David A., additional, Barbe, Jean-Christophe, additional, Barros, António S., additional, Barros, Elisabete B.P., additional, Batenburg, Max, additional, Beisert, Beata, additional, Benet, Lu, additional, Berdeaux, Olivier, additional, Bernhardt, Jörg, additional, Billmayer, Silvia, additional, Bin, Qing, additional, Birch, Anja N., additional, Bishara, Sandra, additional, Blanch, Consol, additional, Blanco, Domingo, additional, Blank, Imre, additional, Boerrigter-Eenling, Rita, additional, Boisard, Lauriane, additional, Bormann, Sebastian, additional, Bou-Maroun, Elias, additional, Boulanger, Renaud, additional, Brandão, Tiago, additional, Breme, Katharina, additional, Brennecke, Stefan, additional, Brockhoff, Anne, additional, Brondel, Laurent, additional, Brown, Keith, additional, Brunerie, Pascal, additional, Bucci, Remo, additional, Buchhaupt, Markus, additional, Bueno, Mónica, additional, Buettner, Andrea, additional, Cabio’ch, Geoffroy, additional, Cacho, Juan, additional, Cadwallader, Keith R., additional, Callejón, Raquel M., additional, Mar Campo, Maria, additional, Cartier, Charlotte, additional, Carvalho, Beatriz, additional, Castro Alves, Victor C., additional, Cayot, Nathalie, additional, Chabanet, Claire, additional, Chaintreau, Alain, additional, Chambault, Adeline, additional, Charlier, Landry, additional, Chassemont, Claire, additional, Chetschik, Irene, additional, Hee Cho, In, additional, Christlbauer, Monika, additional, Claeys Bouuaert, Thomas, additional, Coic, Solenn, additional, Collin, Sonia, additional, Concejero-Pardos, Belén, additional, Coureaud, Gérard, additional, Courter, Chris, additional, Culleré, Laura, additional, Curtin, Chris D., additional, Cypriani, Marie-Louise, additional, Czerny, Michael, additional, Dacremont, Catherine, additional, D’Aloise, Antonio, additional, Daltoé, Marina M., additional, Darriet, Philippe, additional, Davidek, Tomas, additional, de Jong, Catrienus, additional, De La Fuente, Arancha, additional, Degenhardt, Andreas, additional, Dekkers, Renske, additional, Déléris, Isabelle, additional, Deprêtre, Nicolas, additional, Dermiki, Maria, additional, de Revel, Gilles, additional, Desforges, Neil C., additional, Dijkstra, Annereinou, additional, Dobravalskytė, Diana, additional, Dodson, Andrew T., additional, Donadel, Jossiê Z., additional, Dosne, Thibaut, additional, Du, Xiaofen, additional, Dunemann, Frank, additional, Dussort, Pierre, additional, Stephen Elmore, J., additional, Engel, Karl-Heinz, additional, Escalona-Buendia, Hector B., additional, Escudero, Ana, additional, Espitia-Lopez, Josefa, additional, Etschmann, Maria M.W., additional, Féron, Gilles, additional, Ferreira, Vicente, additional, Festring, Daniel, additional, Fiorucci, Sébastien, additional, Fischer, Ulrich, additional, Fisk, Ian D., additional, Floquet, Pascal, additional, Franco-Luesma, Ernesto, additional, Frank, Stephanie, additional, Frapolli, Sophie, additional, Frauendorfer, Felix, additional, Frey, Peter, additional, Fritsch, Stephanie, additional, Gürbüz, Ozan, additional, Ganß, Sebastian, additional, Garruti, Deborah S., additional, Gassenmeier, Klaus, additional, Gerbaud, Vincent, additional, Giaccio, Joanne, additional, Gil, Ana M., additional, Glabasnia, A., additional, Gohr, André, additional, Golebiowski, Jérôme, additional, Gomes, Bruna L., additional, Goncalves, Liseth, additional, Gourrat-Pernin, Karine, additional, Gouttefangeas, Cécile, additional, Gracia-Moreno, Elisa, additional, Graham, Julie, additional, Gray, David A., additional, Groeneschild, Chantalle, additional, Gros, Jacques, additional, Guggenbühl, Barbara, additional, Guichard, Elisabeth, additional, Guillemin, Hervé, additional, Gunata, Ziya, additional, Hancock, Robert D., additional, Handoko, Dody D., additional, Hansen, Åse S., additional, Hartmann, Beate, additional, Haseleu, Gesa, additional, Hausch, Bethany J., additional, Hazelwood, Lucie A., additional, He, Juan, additional, Heinlein, Anja, additional, Hempfling, Katrin, additional, Hernandez-Orte, Purificación, additional, Herrero, Paula, additional, Hilmer, Jens-Michael, additional, Hixson, Josh L., additional, Hofmann, Thomas, additional, Hogekamp, Hermen, additional, Hort, Joanne, additional, Hory, Chantal, additional, Hufnagel, Jan-Carlos, additional, Ibàñez, Carlos, additional, Ibarra, Dominique, additional, Innerhofer, Georg, additional, Jacob-Lopes, Eduardo, additional, Jacquet, Nathalie, additional, Jiang, Deshou, additional, Jones, Lewis L., additional, Jung, Rainer, additional, Kähne, Fenja, additional, Kallio, Heikki P., additional, Kaloya, Sukhraj, additional, Kelderer, Markus, additional, Kennedy, Orla B., additional, Kerler, Josef, additional, Kersch-Counet, Christine, additional, Kessler, Artur, additional, Kindel, Günter, additional, Klein, Dorothee, additional, Kohlenberg, Birgit, additional, Korichi, Mourad, additional, Kort, Miriam, additional, Koschinski, Stefan, additional, Krammer, Gerhard E., additional, Kreißl, Johanna K., additional, Kurtz, Anne J., additional, Kusbiantoro, B., additional, Kwasniewski, Misha T., additional, Laaksonen, Oskar A., additional, Labouré, Hélène, additional, Lafarge, Céline, additional, Lagemann, Annika, additional, Landrieu, Eric, additional, Lardschneider, Ewald, additional, Lavin, Edward H, additional, Lawless, Harry T., additional, Le Bail, Patricia, additional, Le Fur, Yves, additional, Luc Le Quéré, Jean, additional, Leclercq, Catherine, additional, Leite, Selma G.F., additional, Leitner, Erich, additional, Ley, Jakob P., additional, Lieben, Pascale, additional, Liebig, Margit, additional, Linforth, Robert S.T., additional, Lopez, Ricardo, additional, Lorjaroenphon, Yaowapa, additional, Lubbers, Samuel, additional, Lubian, Elisabetta, additional, Lytra, Georgia, additional, Müller, Jakob, additional, Magalhães, Hilton Cesar R., additional, Magrì, Andrea D., additional, Magrì, Antonio L., additional, Mahattanatawee, Kanjana, additional, Mallia, Silvia, additional, Mantzouridou, Fani, additional, Maraval, Isabelle, additional, Marco, Pedro, additional, Marini, Federico, additional, Marshall, James W., additional, Martens, Marty, additional, Mateo-Vivaracho, Laura, additional, May, Bianca, additional, Mayr, Christine M., additional, Medina, Ana Luisa, additional, Meier, Roberto, additional, Mendez-Iturbe, Daniel, additional, Messner, Christine, additional, Methven, Lisa, additional, Meyerhof, Wolfgang, additional, Moncayo, Liliana, additional, Morakul, Sumallika, additional, Morales, Maria Lourdes, additional, Moretton, Cédric, additional, Mort, Emily S., additional, Moser, Mireille, additional, Mottram, Donald S., additional, Mouret, Jean-Roch, additional, Mueller, Stefan, additional, Murat, Chloé, additional, Nalli, Stefano M., additional, Nardo, Nicoletta, additional, Negishi, Osamu, additional, Negishi, Yukiko, additional, Nicoli, Stefano, additional, Nicolle, Pamela, additional, Nigay, Henri, additional, Nijssen, Ben, additional, Nizet, Sabrina, additional, Novotny, Ondrej, additional, Obst, Katja, additional, Olachea-Martínez, Francisco J., additional, Oliveira, Alcilucia, additional, Ontanón, Ignacio, additional, Orth, Anne-Marie, additional, Pabi, Nicole, additional, Paetz, Susanne, additional, Paoletti, Flavio, additional, Paraskevopoulou, Adamantini, additional, Paravisini, Laurianne, additional, Parker, Jane K., additional, Paterson, Alistair, additional, Paula Barros, Elisabete B., additional, Peña, Francisco, additional, Peck, Jim, additional, Peeters, Florence, additional, Peiró, Pere, additional, Penha, Maria Flávia A., additional, Pepin, Liesbeth, additional, Perez, M., additional, Pérez-Cacho, Pilar Ruiz, additional, Petersen, Mikael A., additional, Peterson, Devin G., additional, Pfaffl, Michael W., additional, Pinto, Náyra O.F., additional, Pischetsrieder, Monika, additional, Plyer, Daniel, additional, Poette, Julie, additional, Poisson, Luigi, additional, Ponne, Carina, additional, Poonlaphdecha, Janchai, additional, Poplacean, Iulia, additional, Puputti, Sari, additional, Qannari, El Mostafa, additional, Qian, Michael C., additional, Queiroz, Maria I., additional, Rabillier, Jean-Marc, additional, Raffo, Antonio, additional, Rauhut, Doris, additional, Reichelt, Katharina V., additional, Reifschneider, Francisco J.B., additional, Renault, Anne, additional, Repoux, Marie, additional, Resconi, Virginia C., additional, Rezende, Claudia M., additional, Rivera, Felipe M., additional, Rochat, Sabine, additional, Rodrigues, João A., additional, Rojas, José M., additional, Roques, S. Sandrine, additional, Rouseff, June, additional, Rouseff, Russell L., additional, Ruiz, Daniel, additional, Ruiz-Teran, Francisco, additional, Runge, Christa, additional, Rytz, Andreas, additional, Saadi, Khaled, additional, Sablayrolles, Jean-Marie, additional, Sacks, Gavin L., additional, Sahin, Hilal, additional, Saint-Eve, Anne, additional, Salles, Christian, additional, San Juan, Felipe, additional, Sandell, Mari A., additional, Sandgruber, Stefanie, additional, Santos, Andriéli B., additional, Schäfer, Uwe, additional, Schüttler, Armin, additional, Schaal, Benoist, additional, Schaller, Jean-Pierre, additional, Schieberle, Peter, additional, Schmarr, Hans-Georg, additional, Schmidt, Christina, additional, Schoen, Eric, additional, Scholtes, Caroline, additional, Schrader, Dirk, additional, Schrader, Jens, additional, Schrampf, Eva, additional, Schwab, Wilfried, additional, Schwager, Hugo, additional, Sefton, Mark A., additional, Seilwind, Stefan, additional, Sémon, Etienne, additional, Siegmund, Barbara, additional, Silamba, I., additional, Silva Ferreira, António C., additional, Sinding, Charlotte, additional, Skelton, Susan, additional, Smogrovicova, Daniela, additional, Solà, Josep, additional, Soldevilla, Hortensia Galán, additional, Soles, Rollin, additional, Söllner, Kerstin, additional, Souchon, Isabelle, additional, Stangl, Andreas, additional, Starkenmann, Christian, additional, Steinhaus, Martin, additional, Evelyn Stelzl, M., additional, Stephan, Andreas, additional, Stettner, Georg, additional, Strube, Andrea, additional, Suess, Barbara, additional, Suwankanit, Chutipapha, additional, Swanepoel, Karen M., additional, Talbot, Matthew D., additional, Talou, Thierry, additional, Tarrega, Amparo, additional, Taylor, Andrew, additional, Taylor, Dennis K., additional, Thomas, E., additional, Thomas, Karin, additional, Thomas-Danguin, Thierry, additional, Tissot, Emeline, additional, Toldam-Andersen, Torben, additional, Topin, Jérémie, additional, Torres-Moreno, Miriam, additional, Torri, Aiana F., additional, Tournier, Carole, additional, Trautzsch, Stephan, additional, Tromelin, Anne, additional, Troncoso, Ana M., additional, Úbeda, Cristina, additional, Ulrich, Detlef, additional, Varming, Camilla, additional, Venskutonis, Petras Rimantas, additional, Venturini, Maria E., additional, Verde-Calvo, Jose Ramon, additional, Villmann, Carmen, additional, van der Velden, Rob, additional, Wüst, Matthias, additional, Wagner, Roger, additional, Walsh, Stuart, additional, Wansink, Brian, additional, Wassink, Anne-Marie, additional, Wessjohann, Ludger, additional, Whitaker, Vance, additional, Hanny Wijayaa, Christofora, additional, Williams, Robert C., additional, Wittlake, Rüdiger, additional, Wollmann, Nadine, additional, Yang, Baoru, additional, Yang, Nicole, additional, Yu, Lu, additional, Yvan, Niclass, additional, Yven, Claude, additional, Zapata, Julián, additional, Zepka, Leila Q., additional, and Ziegler, Herta, additional

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2014
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