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2. Large-scale analysis of structural brain asymmetries during neurodevelopment : Associations with age and sex in 4265 children and adolescents.

Author

Kurth, F, Schijven, D, van den Heuvel, O A, Hoogman, M, van Rooij, D, Stein, D J, Buitelaar, J K, Bölte, S, Auzias, G, Kushki, A, Venkatasubramanian, G, Rubia, K, Bollmann, S, Isaksson, J, Jaspers-Fayer, F, Marsh, R, Batistuzzo, M C, Arnold, P D, Bressan, R A, Stewart, S E, Gruner, P, Sorensen, L, Pan, P M, Silk, T J, Gur, R C, Cubillo, A I, Haavik, J, O'Gorman Tuura, R L, Hartman, C A, Calvo, R, McGrath, J, Calderoni, S, Jackowski, A, Chantiluke, K C, Satterthwaite, T D, Busatto, G F, Nigg, J T, Gur, R E, Retico, A, Tosetti, M, Gallagher, L, Szeszko, P R, Neufeld, J, Ortiz, A E, Ghisleni, C, Lazaro, L, Hoekstra, P J, Anagnostou, E, Hoekstra, L, Simpson, B, Plessen, J K, Deruelle, C, Soreni, N, James, A, Narayanaswamy, J, Reddy, J Y, Fitzgerald, J, Bellgrove, M A, Salum, G A, Janssen, J, Muratori, F, Vila, M, Giral, M Garcia, Ameis, S H, Bosco, P, Remnélius, K Lundin, Huyser, C, Pariente, J C, Jalbrzikowski, M, Rosa, P G, O'Hearn, K M, Ehrlich, S, Mollon, J, Zugman, A, Christakou, A, Arango, C, Fisher, S E, Kong, X, Franke, B, Medland, S E, Thomopoulos, S I, Jahanshad, N, Glahn, D C, Thompson, P M, Francks, C, Luders, E, Kurth, F, Schijven, D, van den Heuvel, O A, Hoogman, M, van Rooij, D, Stein, D J, Buitelaar, J K, Bölte, S, Auzias, G, Kushki, A, Venkatasubramanian, G, Rubia, K, Bollmann, S, Isaksson, J, Jaspers-Fayer, F, Marsh, R, Batistuzzo, M C, Arnold, P D, Bressan, R A, Stewart, S E, Gruner, P, Sorensen, L, Pan, P M, Silk, T J, Gur, R C, Cubillo, A I, Haavik, J, O'Gorman Tuura, R L, Hartman, C A, Calvo, R, McGrath, J, Calderoni, S, Jackowski, A, Chantiluke, K C, Satterthwaite, T D, Busatto, G F, Nigg, J T, Gur, R E, Retico, A, Tosetti, M, Gallagher, L, Szeszko, P R, Neufeld, J, Ortiz, A E, Ghisleni, C, Lazaro, L, Hoekstra, P J, Anagnostou, E, Hoekstra, L, Simpson, B, Plessen, J K, Deruelle, C, Soreni, N, James, A, Narayanaswamy, J, Reddy, J Y, Fitzgerald, J, Bellgrove, M A, Salum, G A, Janssen, J, Muratori, F, Vila, M, Giral, M Garcia, Ameis, S H, Bosco, P, Remnélius, K Lundin, Huyser, C, Pariente, J C, Jalbrzikowski, M, Rosa, P G, O'Hearn, K M, Ehrlich, S, Mollon, J, Zugman, A, Christakou, A, Arango, C, Fisher, S E, Kong, X, Franke, B, Medland, S E, Thomopoulos, S I, Jahanshad, N, Glahn, D C, Thompson, P M, Francks, C, and Luders, E

Abstract

Only a small number of studies have assessed structural differences between the two hemispheres during childhood and adolescence. However, the existing findings lack consistency or are restricted to a particular brain region, a specific brain feature, or a relatively narrow age range. Here, we investigated associations between brain asymmetry and age as well as sex in one of the largest pediatric samples to date (n = 4265), aged 1-18 years, scanned at 69 sites participating in the ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) consortium. Our study revealed that significant brain asymmetries already exist in childhood, but their magnitude and direction depend on the brain region examined and the morphometric measurement used (cortical volume or thickness, regional surface area, or subcortical volume). With respect to effects of age, some asymmetries became weaker over time while others became stronger; sometimes they even reversed direction. With respect to sex differences, the total number of regions exhibiting significant asymmetries was larger in females than in males, while the total number of measurements indicating significant asymmetries was larger in males (as we obtained more than one measurement per cortical region). The magnitude of the significant asymmetries was also greater in males. However, effect sizes for both age effects and sex differences were small. Taken together, these findings suggest that cerebral asymmetries are an inherent organizational pattern of the brain that manifests early in life. Overall, brain asymmetry appears to be relatively stable throughout childhood and adolescence, with some differential effects in males and females.

Published
2024
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3. ENIGMA-anxiety working group: Rationale for and organization of large-scale neuroimaging studies of anxiety disorders

Author

Bas-Hoogendam, J. M., Groenewold, N. A., Aghajani, M., Freitag, G. F., Harrewijn, A., Hilbert, K., Jahanshad, N., Thomopoulos, S. I., Thompson, P. M., Veltman, D. J., Winkler, A. M., Lueken, U., Pine, D. S., van der Wee, N. J. A., Stein, D. J., Agosta, F., Ahs, F., An, I., Alberton, B. A. V., Andreescu, C., Asami, T., Assaf, M., Avery, S. N., Nicholas, L., Balderston, Barber, J. P., Battaglia, M., Bayram, A., Beesdo-Baum, K., Benedetti, F., Berta, R., Bjorkstrand, J., Blackford, J. U., Blair, J. R., Karina, S., Blair, Boehme, S., Brambilla, P., Burkhouse, K., Cano, M., Canu, E., Cardinale, E. M., Cardoner, N., Clauss, J. A., Cividini, C., Critchley, H. D., Udo, Dannlowski, Deckert, J., Demiralp, T., Diefenbach, G. J., Domschke, K., Doruyter, A., Dresler, T., Erhardt, A., Fallgatter, A. J., Fananas, L., Brandee, Feola, Filippi, C. A., Filippi, M., Fonzo, G. A., Forbes, E. E., Fox, N. A., Fredrikson, M., Furmark, T., Ge, T., Gerber, A. J., Gosnell, S. N., Grabe, H. J., Grotegerd, D., Gur, R. E., Gur, R. C., Harmer, C. J., Harper, J., Heeren, A., Hettema, J., Hofmann, D., Hofmann, S. G., Jackowski, A. P., Andreas, Jansen, Kaczkurkin, A. N., Kingsley, E., Kircher, T., Kosti c, M., Kreifelts, B., Krug, A., Larsen, B., Lee, S. -H., Leehr, E. J., Leibenluft, E., Lochner, C., Maggioni, E., Makovac, E., Mancini, M., Manfro, G. G., Mansson, K. N. T., Meeten, F., Michalowski, J., Milrod, B. L., Muhlberger, A., Lilianne, R., Mujica-Parodi, Munjiza, A., Mwangi, B., Myers, M., Igor Nenadi, C., Neufang, S., Nielsen, J. A., Oh, H., Ottaviani, C., Pan, P. M., Pantazatos, S. P., Martin, P., Paulus, Perez-Edgar, K., Penate, W., Perino, M. T., Peterburs, J., Pfleiderer, B., Phan, K. L., Poletti, S., Porta-Casteras, D., Price, R. B., Pujol, J., Andrea, Reinecke, Rivero, F., Roelofs, K., Rosso, I., Saemann, P., Salas, R., Salum, G. A., Satterthwaite, T. D., Schneier, F., Schruers, K. R. J., Schulz, S. M., Schwarzmeier, H., Seeger, F. R., Smoller, J. W., Soares, J. C., Stark, R., Stein, M. B., Straube, B., Straube, T., Strawn, J. R., Suarez-Jimenez, B., Boris, Suchan, Sylvester, C. M., Talati, A., Tamburo, E., Tukel, R., van den Heuvel, O. A., Van der Auwera, S., van Nieuwenhuizen, H., van Tol, M. -J., van Velzen, L. S., Bort, C. V., Vermeiren, R. R. J. M., Visser, R. M., Volman, I., Wannemuller, A., Wendt, J., Werwath, K. E., Westenberg, P. M., Wiemer, J., Katharina, Wittfeld, M. -J., Wu, Yang, Y., Zilverstand, A., Zugman, A., Zwiebel, H. L., Bas-Hoogendam, J. M., Groenewold, N. A., Aghajani, M., Freitag, G. F., Harrewijn, A., Hilbert, K., Jahanshad, N., Thomopoulos, S. I., Thompson, P. M., Veltman, D. J., Winkler, A. M., Lueken, U., Pine, D. S., van der Wee, N. J. A., Stein, D. J., ENIGMA-anxiety working, Group, Filippi, M, and UCL - SSH/IPSY - Psychological Sciences Research Institute

Subjects
Córtex pré-frontal, Review Article, Anxiety, Prefrontal cortex, Specific phobia, 0302 clinical medicine, limbic system, magnetic resonance imaging, Multicenter Studies as Topic, genetics, Review Articles, prefrontal cortex, neuroimaging, Radiological and Ultrasound Technology, 05 social sciences, Social anxiety, amygdala, Amygdala, Anxiety Disorders, Transtornos de ansiedade, Neurology, multicentric network, Anatomy, medicine.symptom, Psychology, Neurovetenskaper, Clinical psychology, endocrine system, Generalized anxiety disorder, brain, Neuroimaging, Sistema límbico, 050105 experimental psychology, 03 medical and health sciences, Global mental health, Limbic system, Magnetic resonance imaging, Imatges per ressonància magnètica, medicine, Genetics, Humans, 0501 psychology and cognitive sciences, Radiology, Nuclear Medicine and imaging, Neuroimagem, Psykologi (exklusive tillämpad psykologi), Panic disorder, neurosciences, Imageamento por ressonância magnética, Tonsila do cerebelo, medicine.disease, anxiety disorders, Genética, Psychology (excluding Applied Psychology), Ansietat, Neurology (clinical), Working group, 030217 neurology & neurosurgery, Anxiety disorders
Abstract

Anxiety disorders are highly prevalent and disabling but seem particularly tractable to investigation with translational neuroscience methodologies. Neuroimaging has informed our understanding of the neurobiology of anxiety disorders, but research has been limited by small sample sizes and low statistical power, as well as heterogenous imaging methodology. The ENIGMA‐Anxiety Working Group has brought together researchers from around the world, in a harmonized and coordinated effort to address these challenges and generate more robust and reproducible findings. This paper elaborates on the concepts and methods informing the work of the working group to date, and describes the initial approach of the four subgroups studying generalized anxiety disorder, panic disorder, social anxiety disorder, and specific phobia. At present, the ENIGMA‐Anxiety database contains information about more than 100 unique samples, from 16 countries and 59 institutes. Future directions include examining additional imaging modalities, integrating imaging and genetic data, and collaborating with other ENIGMA working groups. The ENIGMA consortium creates synergy at the intersection of global mental health and clinical neuroscience, and the ENIGMA‐Anxiety Working Group extends the promise of this approach to neuroimaging research on anxiety disorders., Anxiety disorders are highly prevalent and disabling but seem particularly tractable to investigation with translational neuroscience methodologies. Neuroimaging has informed our understanding of the neurobiology of anxiety disorders, but research has been limited by small sample sizes and low statistical power, as well as heterogenous imaging methodology. The ENIGMA‐Anxiety Working Group has brought together researchers from around the world, in a harmonized and coordinated effort to address these challenges and generate more robust and reproducible findings. The ENIGMA consortium creates synergy at the intersection of global mental health and clinical neuroscience, and the ENIGMA‐Anxiety Working Group extends the promise of this approach to neuroimaging research on anxiety disorders.

Published
2020

4. Subcortical Volume Trajectories across the Lifespan: Data from 18,605 healthy individuals aged 3-90 years

Author

Dima, D., Papachristou, E., Modabbernia, A., Doucet, G. E., Agartz, I., Aghajani, M., Akudjedu, T. N., Albajes-Eizagirre, A., Alnæs, D., Alpert, K. I., Andersson, M., Andreasen, N., Andreassen, O. A., Asherson, P., Banaschewski, T., Bargallo, N., Baumeister, S., Baur-Streubel, R., Bertolino, A., Bonvino, A., Boomsma, D. I., Borgwardt, S., Bourque, J., Brandeis, D., Breier, A., Brodaty, H., Brouwer, R. M., Buitelaar, J. K., Busatto, G. F., Buckner, R. L., Calhoun, V., Canales-Rodríguez, E. J., Cannon, D. M., Caseras, X., Castellanos, F. X., Cervenka, S., Chaim-Avancini, T. M., Ching, C. R. K., Clark, V. P., Conrod, P., Conzelmann, A., Crespo-Facorro, B., Crivello, F., Crone, E. A. M., Dale, A. M., Davey, C., de Geus, E. J. C., de Haan, L., de Zubicaray, G. I., den Braber, A., Dickie, E. W., Di Giorgio, A., Doan, N. T., Dørum, E. S., Ehrlich, S., Erk, S., Espeseth, T., Fatouros-Bergman, H., Fisher, S. E., Fouche, J-P., Franke, B., Frodl, T., Fuentes-Claramonte, P., Glahn, D. C., Gotlib, I. H., Grabe, H-J., Grimm, O., Groenewold, N. A., Grotegerd, D., Gruber, O., Gruner, P., Gur, R. E., Gur, R. C., Harrison, B. J., Hartman, C. A., Hatton, S. N., Heinz, A., Heslenfeld, D. J., Hibar, D. P., Hickie, I. B., Ho, B-C., Hoekstra, P. J., Hohmann, S., Holmes, A. J., Hoogman, M., Hosten, N., Howells, F. M., Hulshoff Pol, H. E., Huyser, C., Jahanshad, N., James, A., Jiang, J., Jönsson, E. G., Joska, J. A., Kahn, R., Kalnin, A., Kanai, R., Kang, S., Klein, M., Klushnik, T. P., Koenders, L., Koops, S., Krämer, B., Kuntsi, J., Lagopoulos, J., Lázaro, L., Lebedeva, I., Lee, W. H., Lesch, K-P., Lochner, C., Machielsen, M. W. J., Maingault, S., Martin, N. G., Martínez-Zalacaín, I., Mataix-Cols, D., Mazoyer, B., McDonald, C., McDonald, B. C., McIntosh, A. M., McMahon, K. L., McPhilemy, G., Menchón, J. M., Medland, S. E., Meyer-Lindenberg, A., Naaijen, J., Najt, P., Nakao, T., Nordvik, J. E., Nyberg, L., Oosterlaan, J., de la Foz, V. O-G., Paloyelis, Y., Pauli, P., Pergola, G., Pomarol-Clotet, E., Portella, M. J., Potkin, S. G., Radua, J., Reif, A., Roffman, J. L., Rosa, P. G. P., Sacchet, M. D., Sachdev, P. S., Salvador, R., Sánchez-Juan, P., Sarró, S., Satterthwaite, T. D., Saykin, A. J., Serpa, M. H., Schmaal, L., Schnell, K., Schumann, G., Smoller, J. W., Sommer, I., Soriano-Mas, C., Stein, D. J., Strike, L. T., Swagerman, S. C., Tamnes, C. K., Temmingh, H. S., Thomopoulos, S. I., Tomyshev, A. S., Tordesillas-Gutiérrez, D., Trollor, J. N., Turner, J. A., Uhlmann, A., van den Heuvel, O. A., van den Meer, D., van der Wee, N. J. A., van Haren, N. E. M., van ’t Ent, D., van Erp, T. G. M., Veer, I. M., Veltman, D. J., Völzke, H., Walter, H., Walton, E., Wang, L., Wang, Y., Wassink, T. H., Weber, B., Wen, W., West, J. D., Westlye, L. T., Whalley, H., Wierenga, L. M., Williams, S. C. R., Wittfeld, K., Wolf, D. H., Worker, A., Wright, M. J., Yang, K., Yoncheva, Y., Zanetti, M. V., Ziegler, G. C., Thompson, P. M., and Frangou, S.

Subjects
nervous system, BF
Abstract

Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies and may obscure or distort the lifespan trajectories of brain morphometry. In response, we capitalised on the resources of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to examine the age-related morphometric trajectories of the ventricles, the basal ganglia (caudate, putamen, pallidum, and nucleus accumbens), the thalamus, hippocampus and amygdala using magnetic resonance imaging data obtained from 18,605 individuals aged 3-90 years. All subcortical structure volumes were at their maximum early in life; the volume of the basal ganglia showed a gradual monotonic decline thereafter while the volumes of the thalamus, amygdala and the hippocampus remained largely stable (with some degree of decline in thalamus) until the sixth decade of life followed by a steep decline thereafter. The lateral ventricles showed a trajectory of continuous enlargement throughout the lifespan. Significant age-related increase in inter-individual variability was found for the hippocampus and amygdala and the lateral ventricles. These results were robust to potential confounders and could be used to derive risk predictions for the early identification of diverse clinical phenotypes.

5. Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3–90 years

Author

Dima, D., Modabbernia, A., Papachristou4, E., Doucet, G. E., Agartz, I., Aghajani, M., Akudjedu, Theophilus. N., Albajes-Eizagirre, A., Alnaes, D, Alpert, K. I., Andersson, M., Andreasen, N. C., Andreassen, O. A., Asherson, P., Banaschewski, T., Bargallo, N., Baumeister, S., Baur-Streubel, R., Bertolino, A., Bonvino, A., Boomsma, D. I., Borgwardt, S., Bourque, J., Brandeis, D., Breier, A., Brodaty, H., Brouwer, R. M., Buitelaar, J. K., Busatto, G. F., Buckner, R. L., Calhoun, V., Canales-Rodríguez, E. J., Cannon, D. M., Caseras, X., Castellanos, F. X., Cervenka, S, Chaim-Avancini, T. M., Ching, C. R. K., Chubar, V., Clark, V. P., Conrod, P., Conzelmann, A., Crespo-Facorro, B, Crivello, F., Crone, E. A., Dale, A. M., Davey, C., de Geus, E. J. C, de Haan, L., de Zubicaray, G. I., den Braber, A., Dickie, E. W., Di Giorgio, A., Doan, N. T., Dørum, E. S., Ehrlich, S., Erk, S., Espeseth, T., Fatouros- Bergman, H., Fisher, S. E., Fouche, J. P., Franke, B., Frodl, T., Fuentes-Claramonte, P., Glahn, D. C., Gotlib, I. H., Grabe, H. J., Grimm, O., Groenewold, N. A., Grotegerd, D., Gruber, O., Gruner, P., Gur, R. E., Gur, R. C., Harrison, B. J., Hartman, C. A., Hatton, S. N., Heinz, A., Heslenfeld, D. J., Hibar, D. P., Hickie, I. B., Ho, B. C., Hoekstra, P. J., Hohmann, S., Holmes, A. J., Hoogman, M., Hosten, N., Howells, F. M., Hulshoff Pol, H. E., Huyser, C., Jahanshad, N., James, A., Jernigan, T. L., Jiang, J., Jönsson, E. G., Joska, J. A., Kahn, R., Kalnin, A., Kanai, R., Klein, M., Klyushnik, T. P., Koenders, L., Koops, S., Krämer, B., Kuntsi, J., Lagopoulos, J., Lázaro, L., Lebedeva, I., Lee, W. H., Lesch, K. P., Lochner, C., Machielsen, M. W. J., Maingault, S., Martin, N. G., Martínez-Zalacaín, I., Mataix-Cols, D., Mazoyer, B., McDonald, C., McDonald, B. C., McIntosh, A. M., McMahon, K. L., McPhilemy, G., Menchón, J. M., Medland, S. E., Meyer-Lindenberg, A., Naaijen, J., Najt, P., Nakao, T., Nordvik, J. E., Nyberg, L., Oosterlaan, J., Ortiz-García de la Foz, V., Paloyelis, Y., Pauli, P., Pergola, G., Pomarol-Clotet, E., Portella, M. J., Potkin, S. G., Radua, J., Reif, A., Rinker, D. A., Roffman, J. L., Rosa, P. G. P., Sacchet, M. D., Sachdev, P. S., Salvador, R., Sánchez-Juan, P., Sarró, S., Satterthwaite, T. D., Saykin, A. J., Serpa, M. H., Schmaal, L., Schnell, K., Schumann, G., Sim, K., Smoller, J. W., Sommer, I., Soriano-Mas, C., Stein, D. J., Strike, L. T., Swagerman, S. C., Tamnes, C. K., Temmingh, H. S., Thomopoulos, S. I., Tomyshev, A. S., Tordesillas-Gutiérrez, D., Trollor, J. N., Turner, J. A., Uhimann, A., van den Heuvel, O. A., van den Meer, D., van der Wee, N. J. A., van Haren, N. E. M., van't Ent, D., van Erp, T. G. M., Veer, I. M., Veltman, D. J., Voineskos, A., Völzke, H., Walter, H., Walton, E., Wang, L., Wang, Y., Wassink, T. H., Weber, B., Wen, W., West, J. D., Westlye, L. T., Whalley, H., Wierenga, L. M., Williams, S. C. R., Wittfeld, K., Wolf, D. H., Worker, A., Wright, M. J., Yang, K., Yoncheva, Y., Zanetti, M. V., Ziegler, G. C., Thompson, P. M., Frangou, S., Karolinska Schizophrenia Project (KaSP), Dima, D., Modabbernia, A., Papachristou4, E., Doucet, G. E., Agartz, I., Aghajani, M., Akudjedu, Theophilus. N., Albajes-Eizagirre, A., Alnaes, D, Alpert, K. I., Andersson, M., Andreasen, N. C., Andreassen, O. A., Asherson, P., Banaschewski, T., Bargallo, N., Baumeister, S., Baur-Streubel, R., Bertolino, A., Bonvino, A., Boomsma, D. I., Borgwardt, S., Bourque, J., Brandeis, D., Breier, A., Brodaty, H., Brouwer, R. M., Buitelaar, J. K., Busatto, G. F., Buckner, R. L., Calhoun, V., Canales-Rodríguez, E. J., Cannon, D. M., Caseras, X., Castellanos, F. X., Cervenka, S, Chaim-Avancini, T. M., Ching, C. R. K., Chubar, V., Clark, V. P., Conrod, P., Conzelmann, A., Crespo-Facorro, B, Crivello, F., Crone, E. A., Dale, A. M., Davey, C., de Geus, E. J. C, de Haan, L., de Zubicaray, G. I., den Braber, A., Dickie, E. W., Di Giorgio, A., Doan, N. T., Dørum, E. S., Ehrlich, S., Erk, S., Espeseth, T., Fatouros- Bergman, H., Fisher, S. E., Fouche, J. P., Franke, B., Frodl, T., Fuentes-Claramonte, P., Glahn, D. C., Gotlib, I. H., Grabe, H. J., Grimm, O., Groenewold, N. A., Grotegerd, D., Gruber, O., Gruner, P., Gur, R. E., Gur, R. C., Harrison, B. J., Hartman, C. A., Hatton, S. N., Heinz, A., Heslenfeld, D. J., Hibar, D. P., Hickie, I. B., Ho, B. C., Hoekstra, P. J., Hohmann, S., Holmes, A. J., Hoogman, M., Hosten, N., Howells, F. M., Hulshoff Pol, H. E., Huyser, C., Jahanshad, N., James, A., Jernigan, T. L., Jiang, J., Jönsson, E. G., Joska, J. A., Kahn, R., Kalnin, A., Kanai, R., Klein, M., Klyushnik, T. P., Koenders, L., Koops, S., Krämer, B., Kuntsi, J., Lagopoulos, J., Lázaro, L., Lebedeva, I., Lee, W. H., Lesch, K. P., Lochner, C., Machielsen, M. W. J., Maingault, S., Martin, N. G., Martínez-Zalacaín, I., Mataix-Cols, D., Mazoyer, B., McDonald, C., McDonald, B. C., McIntosh, A. M., McMahon, K. L., McPhilemy, G., Menchón, J. M., Medland, S. E., Meyer-Lindenberg, A., Naaijen, J., Najt, P., Nakao, T., Nordvik, J. E., Nyberg, L., Oosterlaan, J., Ortiz-García de la Foz, V., Paloyelis, Y., Pauli, P., Pergola, G., Pomarol-Clotet, E., Portella, M. J., Potkin, S. G., Radua, J., Reif, A., Rinker, D. A., Roffman, J. L., Rosa, P. G. P., Sacchet, M. D., Sachdev, P. S., Salvador, R., Sánchez-Juan, P., Sarró, S., Satterthwaite, T. D., Saykin, A. J., Serpa, M. H., Schmaal, L., Schnell, K., Schumann, G., Sim, K., Smoller, J. W., Sommer, I., Soriano-Mas, C., Stein, D. J., Strike, L. T., Swagerman, S. C., Tamnes, C. K., Temmingh, H. S., Thomopoulos, S. I., Tomyshev, A. S., Tordesillas-Gutiérrez, D., Trollor, J. N., Turner, J. A., Uhimann, A., van den Heuvel, O. A., van den Meer, D., van der Wee, N. J. A., van Haren, N. E. M., van't Ent, D., van Erp, T. G. M., Veer, I. M., Veltman, D. J., Voineskos, A., Völzke, H., Walter, H., Walton, E., Wang, L., Wang, Y., Wassink, T. H., Weber, B., Wen, W., West, J. D., Westlye, L. T., Whalley, H., Wierenga, L. M., Williams, S. C. R., Wittfeld, K., Wolf, D. H., Worker, A., Wright, M. J., Yang, K., Yoncheva, Y., Zanetti, M. V., Ziegler, G. C., Thompson, P. M., Frangou, S., and Karolinska Schizophrenia Project (KaSP)

Abstract

Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies and may obscure or distort the lifespan trajectories of brain morphometry. In response, we capitalized on the resources of the Enhancing Neuroimaging Genetics through Meta‐Analysis (ENIGMA) Consortium to examine age‐related trajectories inferred from cross‐sectional measures of the ventricles, the basal ganglia (caudate, putamen, pallidum, and nucleus accumbens), the thalamus, hippocampus and amygdala using magnetic resonance imaging data obtained from 18,605 individuals aged 3–90 years. All subcortical structure volumes were at their maximum value early in life. The volume of the basal ganglia showed a monotonic negative association with age thereafter; there was no significant association between age and the volumes of the thalamus, amygdala and the hippocampus (with some degree of decline in thalamus) until the sixth decade of life after which they also showed a steep negative association with age. The lateral ventricles showed continuous enlargement throughout the lifespan. Age was positively associated with inter‐individual variability in the hippocampus and amygdala and the lateral ventricles. These results were robust to potential confounders and could be used to examine the functional significance of deviations from typical age‐related morphometric patterns.

6. What we learn about bipolar disorder from large-scale neuroimaging

Author

Christian K. Tamnes, Bartholomeus C M Haarman, Jair C. Soares, Ole A. Andreassen, Viola Oertel, Theodore D. Satterthwaite, G. Tronchin, Michael Stäblein, Bradley J. MacIntosh, Melissa Pauling, Christopher R.K. Ching, Daniel H. Wolf, Dick J. Veltman, Ingrid Agartz, Bernhard T. Baune, Salvador Sarró, Mon-Ju Wu, Scott C Fears, Eduard Vieta, Melissa J. Green, Neeltje E.M. van Haren, Yann Quidé, Erlend Bøen, Yash Patel, Igor Nenadic, Martin Alda, Lisa T. Eyler, Arnaud Pouchon, Danai Dima, Tomáš Paus, Irene Bollettini, Torbjørn Elvsåshagen, Rachel M. Brouwer, Lakshmi N. Yatham, Michael Bauer, Caterina del Mar Bonnín, C. McDonald, Udo Dannlowski, Bronwyn Overs, Edith Pomarol-Clotet, Cristian Vargas Upegui, Oliver Gruber, Henricus G. Ruhé, Márcio Gerhardt Soeiro-de-Souza, Edouard Duchesnay, Hilary P. Blumberg, Tilo Kircher, Miho Ota, Michael Berk, Christoph Abé, Andreas Jansen, Kang Sim, Heather C. Whalley, Derrek P. Hibar, Roel A. Ophoff, Georgios V Thomaidis, Henrik Walter, Sophia Frangou, Michèle Wessa, Dara M. Cannon, Cara M. Altimus, Allison C. Nugent, Rodrigo Machado-Vieira, Orwa Dandash, Marcella Bellani, Unn K. Haukvik, Philip B. Mitchell, Ling-Li Zeng, Christian Knöchel, Jose Manuel Goikolea, Sonja M C de Zwarte, Francesco Benedetti, Sara Poletti, Janice M. Fullerton, Carlos A. Zarate, Aart H. Schene, Dan J. Stein, Chantal Henry, Tristram A. Lett, Mikael Landén, Daniel L Pham, Paolo Brambilla, Silvia Alonso-Lana, Sophia I. Thomopoulos, Carlos López-Jaramillo, Tomas Hajek, Bernd Kramer, G. Delvecchio, Maria M. Rive, Lars T. Westlye, Erick J. Canales-Rodríguez, Victoria L. Ives-Deliperi, Dominik Grotegerd, Beny Lafer, Abraham Nunes, Carrie E. Bearden, Raymond Salvador, Joaquim Radua, Amy C Bilderbeck, Xavier Caseras, Paul M. Thompson, Jorge R. C. Almeida, Pauline Favre, Gloria Roberts, David C. Glahn, Dag Alnæs, Julian A Pineda-Zapata, Tiril P. Gurholt, Mircea Polosan, Josselin Houenou, Fabiano G. Nery, Leila Nabulsi, Mary L. Phillips, Fleur M. Howells, Ana M. Díaz-Zuluaga, Elisa M T Melloni, Ching, C. R. K., Hibar, D. P., Gurholt, T. P., Nunes, A., Thomopoulos, S. I., Abe, C., Agartz, I., Brouwer, R. M., Cannon, D. M., de Zwarte, S. M. C., Eyler, L. T., Favre, P., Hajek, T., Haukvik, U. K., Houenou, J., Landen, M., Lett, T. A., Mcdonald, C., Nabulsi, L., Patel, Y., Pauling, M. E., Paus, T., Radua, J., Soeiro-de-Souza, M. G., Tronchin, G., van Haren, N. E. M., Vieta, E., Walter, H., Zeng, L. -L., Alda, M., Almeida, J., Alnaes, D., Alonso-Lana, S., Altimus, C., Bauer, M., Baune, B. T., Bearden, C. E., Bellani, M., Benedetti, F., Berk, M., Bilderbeck, A. C., Blumberg, H. P., Boen, E., Bollettini, I., del Mar Bonnin, C., Brambilla, P., Canales-Rodriguez, E. J., Caseras, X., Dandash, O., Dannlowski, U., Delvecchio, G., Diaz-Zuluaga, A. M., Dima, D., Duchesnay, E., Elvsashagen, T., Fears, S. C., Frangou, S., Fullerton, J. M., Glahn, D. C., Goikolea, J. M., Green, M. J., Grotegerd, D., Gruber, O., Haarman, B. C. M., Henry, C., Howells, F. M., Ives-Deliperi, V., Jansen, A., Kircher, T. T. J., Knochel, C., Kramer, B., Lafer, B., Lopez-Jaramillo, C., Machado-Vieira, R., Macintosh, B. J., Melloni, E. M. T., Mitchell, P. B., Nenadic, I., Nery, F., Nugent, A. C., Oertel, V., Ophoff, R. A., Ota, M., Overs, B. J., Pham, D. L., Phillips, M. L., Pineda-Zapata, J. A., Poletti, S., Polosan, M., Pomarol-Clotet, E., Pouchon, A., Quide, Y., Rive, M. M., Roberts, G., Ruhe, H. G., Salvador, R., Sarro, S., Satterthwaite, T. D., Schene, A. H., Sim, K., Soares, J. C., Stablein, M., Stein, D. J., Tamnes, C. K., Thomaidis, G. V., Upegui, C. V., Veltman, D. J., Wessa, M., Westlye, L. T., Whalley, H. C., Wolf, D. H., Wu, M. -J., Yatham, L. N., Zarate, C. A., Thompson, P. M., and Andreassen, O. A.

Subjects
mega-analysis, Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13], cortical surface area, Review Article, 0302 clinical medicine, Manic-depressive illness, Multicenter Studies as Topic, Spectrum disorder, Review Articles, bipolar disorder, Cerebral Cortex, Trastorn bipolar, neuroimaging, Radiological and Ultrasound Technology, 05 social sciences, ENIGMA, HUMAN BRAIN, Magnetic Resonance Imaging, psychiatry, 3. Good health, Neurology, Meta-analysis, Scale (social sciences), Anatomy, Psychology, Clinical risk factor, Clinical psychology, MRI, MAJOR PSYCHIATRIC-DISORDERS, Schizoaffective disorder, 050105 experimental psychology, 03 medical and health sciences, Magnetic resonance imaging, Neuroimaging, Meta-Analysis as Topic, SDG 3 - Good Health and Well-being, Imatges per ressonància magnètica, medicine, Humans, 0501 psychology and cognitive sciences, Radiology, Nuclear Medicine and imaging, Bipolar disorder, HIPPOCAMPAL VOLUMES, mega‐analysis, GRAY-MATTER VOLUME, SPECTRUM DISORDER, volume, DIABETES-MELLITUS, cortical thickness, COGNITIVE IMPAIRMENT, medicine.disease, Mental illness, meta-analysis, meta‐analysis, RC0321, Neurology (clinical), SCHIZOAFFECTIVE DISORDER, PSYCHOTIC FEATURES, 030217 neurology & neurosurgery
Abstract

MRI‐derived brain measures offer a link between genes, the environment and behavior and have been widely studied in bipolar disorder (BD). However, many neuroimaging studies of BD have been underpowered, leading to varied results and uncertainty regarding effects. The Enhancing Neuro Imaging Genetics through Meta‐Analysis (ENIGMA) Bipolar Disorder Working Group was formed in 2012 to empower discoveries, generate consensus findings and inform future hypothesis‐driven studies of BD. Through this effort, over 150 researchers from 20 countries and 55 institutions pool data and resources to produce the largest neuroimaging studies of BD ever conducted. The ENIGMA Bipolar Disorder Working Group applies standardized processing and analysis techniques to empower large‐scale meta‐ and mega‐analyses of multimodal brain MRI and improve the replicability of studies relating brain variation to clinical and genetic data. Initial BD Working Group studies reveal widespread patterns of lower cortical thickness, subcortical volume and disrupted white matter integrity associated with BD. Findings also include mapping brain alterations of common medications like lithium, symptom patterns and clinical risk profiles and have provided further insights into the pathophysiological mechanisms of BD. Here we discuss key findings from the BD working group, its ongoing projects and future directions for large‐scale, collaborative studies of mental illness., This review discusses the major challenges facing neuroimaging research of bipolar disorder and highlights the major accomplishments, ongoing challenges and future goals of the ENIGMA Bipolar Disorder Working Group.

Published
2022

7. Longitudinal structural brain changes in bipolar disorder: A multicenter neuroimaging study of 1232 individuals by the ENIGMA Bipolar Disorder Working Group

Author

Theophilus N. Akudjedu, Frederike Stein, Edith Pomarol-Clotet, Lars T. Westlye, Ulrik Fredrik Malt, Erlend Bøen, Fabian Breuer, Chao Suo, Tina Meller, Tim Hahn, Francesco Benedetti, Jose Manuel Goikolea, Silvia Alonso-Lana, Adam George White, Dag Alnæs, Julia-Katharina Pfarr, Beathe Haatveit, Sara Poletti, Kai Ringwald, Nathalia Zak, Benny Liberg, Kelvin Sarink, Giulia Tronchin, Yann Chye, Janice M. Fullerton, Orwa Dandash, Igor Nenadic, Caterina del Mar Bonnín, Elisa M T Melloni, Udo Dannlowski, Michael Berk, Dominik Grotegerd, Christopher R.K. Ching, Lukas Fisch, Torbjørn Elvsåshagen, Andreas Dahl, Martin Alda, Francesco Panicalli, Ingrid Agartz, Martin Ingvar, Bronwyn Overs, Joaquim Radua, Katharina Brosch, Alexander V. Lebedev, Kang Sim, Tilo Kircher, Leila Nabulsi, Dara M. Cannon, Erick J. Canales-Rodríguez, Paul M. Thompson, Nils Opel, Jonathan Repple, R. Salvador, Katharina Dohm, Philip B. Mitchell, Colm McDonald, Salvador Sarró, Rachel M. Brouwer, Ole A. Andreassen, Tomas Hajek, Mikael Landén, Simon Schmitt, Sophia I. Thomopoulos, Elena Rodriguez-Cano, Eduard Vieta, Ingrid Melle, Rhoshel K. Lenroot, Lakshmi N. Yatham, Sean R. McWhinney, Gloria Roberts, Christoph Abé, Walter Heindel, Abe, C., Ching, C. R. K., Liberg, B., Lebedev, A. V., Agartz, I., Akudjedu, T. N., Alda, M., Alnaes, D., Alonso-Lana, S., Benedetti, F., Berk, M., Boen, E., Bonnin, C. D. M., Breuer, F., Brosch, K., Brouwer, R. M., Canales-Rodriguez, E. J., Cannon, D. M., Chye, Y., Dahl, A., Dandash, O., Dannlowski, U., Dohm, K., Elvsashagen, T., Fisch, L., Fullerton, J. M., Goikolea, J. M., Grotegerd, D., Haatveit, B., Hahn, T., Hajek, T., Heindel, W., Ingvar, M., Sim, K., Kircher, T. T. J., Lenroot, R. K., Malt, U. F., Mcdonald, C., Mcwhinney, S. R., Melle, I., Meller, T., Melloni, E. M. T., Mitchell, P. B., Nabulsi, L., Nenadic, I., Opel, N., Overs, B. J., Panicalli, F., Pfarr, J. -K., Poletti, S., Pomarol-Clotet, E., Radua, J., Repple, J., Ringwald, K. G., Roberts, G., Rodriguez-Cano, E., Salvador, R., Sarink, K., Sarro, S., Schmitt, S., Stein, F., Suo, C., Thomopoulos, S. I., Tronchin, G., Vieta, E., Westlye, L. T., White, A. G., Yatham, L. N., Zak, N., Thompson, P. M., Andreassen, O. A., Landen, M., Complex Trait Genetics, and Amsterdam Neuroscience - Complex Trait Genetics

Subjects
Adult, Male, Longitudinal study, medicine.medical_specialty, Bipolar disorder, Neuroimaging, volume changes, surface-based analysis, Young Adult, gray-matter, Cortex (anatomy), Internal medicine, medicine, Humans, Multicenter Studies as Topic, Biological Psychiatry, mri, human cerebral-cortex, Psychiatry, medicine.diagnostic_test, business.industry, ENIGMA, Brain, Magnetic resonance imaging, Cerebral Cortical Thinning, Middle Aged, cortical thickness, medicine.disease, Magnetic Resonance Imaging, Neuroprogression, Mania, genetic influences, medicine.anatomical_structure, Mood, Meta-analysis, Cardiology, lithium treatment, Female, medicine.symptom, i disorder, business, metaanalysis
Abstract

Background: Bipolar disorder (BD) is associated with cortical and subcortical structural brain abnormalities. It is unclear whether such alterations progressively change over time, and how this is related to the number of mood episodes. To address this question, we analyzed a large and diverse international sample with longitudinal magnetic resonance imaging (MRI) and clinical data to examine structural brain changes over time in BD. Methods: Longitudinal structural MRI and clinical data from the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) BD Working Group, including 307 patients with BD and 925 healthy control subjects, were collected from 14 sites worldwide. Male and female participants, aged 40 ± 17 years, underwent MRI at 2 time points. Cortical thickness, surface area, and subcortical volumes were estimated using FreeSurfer. Annualized change rates for each imaging phenotype were compared between patients with BD and healthy control subjects. Within patients, we related brain change rates to the number of mood episodes between time points and tested for effects of demographic and clinical variables. Results: Compared with healthy control subjects, patients with BD showed faster enlargement of ventricular volumes and slower thinning of the fusiform and parahippocampal cortex (0.18 < d < 0.22). More (hypo)manic episodes were associated with faster cortical thinning, primarily in the prefrontal cortex. Conclusions: In the hitherto largest longitudinal MRI study on BD, we did not detect accelerated cortical thinning but noted faster ventricular enlargements in BD. However, abnormal frontocortical thinning was observed in association with frequent manic episodes. Our study yields insights into disease progression in BD and highlights the importance of mania prevention in BD treatment.

Published
2022

8. In vivo hippocampal subfield volumes in bipolar disorder-A mega-analysis from The Enhancing Neuro Imaging Genetics throughMeta-AnalysisBipolar Disorder Working Group

Author

Sophia I. Thomopoulos, Julian A Pineda-Zapata, Ronny Redlich, Bartholomeus C M Haarman, Mathew A. Harris, Orwa Dandash, Ulrik Fredrik Malt, Lauren E. Salminen, Michael Stäblein, Theo G.M. van Erp, Gloria Roberts, Michael Berk, Jochen Bauer, Edith Pomarol-Clotet, Carlos López-Jaramillo, Dominik Grotegerd, Tomas Hajek, Paul M. Thompson, Philipp G. Sämann, Francesco Benedetti, Tilo Kircher, Brian Hallahan, Jonathan Repple, Lena Waltemate, Maria M. Rive, Heather C. Whalley, Caterina del Mar Bonnín, Oliver Gruber, Igor Nenadic, Udo Dannlowski, Henricus G. Ruhé, Raymond Salvador, Bronwyn Overs, Torbjørn Elvsåshagen, Márcio Gerhardt Soeiro-de-Souza, Ana M. Díaz-Zuluaga, Katharina Förster, Jose Manuel Goikolea, Emma L. Hawkins, Vera Lonning, Silvia Alonso-Lana, Dan J. Stein, Theophilus N. Akudjedu, Elisa M T Melloni, Dag Alnæs, Nils Opel, Martin Alda, Rayus Kuplicki, Erlend Bøen, Salvador Sarró, Unn K. Haukvik, Philip B. Mitchell, Kang Sim, Lisa Rauer, Ole A. Andreassen, Colm McDonald, Eduard Vieta, Erick J. Canales-Rodríguez, Axel Krug, Viola Oertel, Frederike Stein, Xavier Caseras, Christopher R.K. Ching, Lucio Oldani, Dara M. Cannon, Andrew M. McIntosh, Kjetil Nordbø Jørgensen, Ingrid Melle, Rhoshel K. Lenroot, Lars T. Westlye, Giuseppe Delvecchio, Dick J. Veltman, Mar Fatjó-Vilas, Trine Vik Lagerberg, Leila Nabulsi, Henk Temmingh, Carina Hülsmann, Francesco Bettella, Paolo Brambilla, Dennis van der Meer, Sonya Foley, Tiril P. Gurholt, Fleur M. Howells, Joaquim Radua, Thomas M. Lancaster, Christian K. Tamnes, Maria Cg Otaduy, Jonathan Savitz, Stener Nerland, Genevieve McPhilemy, Janice M. Fullerton, Aart H. Schene, Neda Jahanshad, Ingrid Agartz, Bernhard T. Baune, Beathe Haatveit, Bernd Krämer, Psychiatrie & Neuropsychologie, RS: MHeNs - R2 - Mental Health, Haukvik, U. K., Gurholt, T. P., Nerland, S., Elvsashagen, T., Akudjedu, T. N., Alda, M., Alnaes, D., Alonso-Lana, S., Bauer, J., Baune, B. T., Benedetti, F., Berk, M., Bettella, F., Boen, E., Bonnin, C. M., Brambilla, P., Canales-Rodriguez, E. J., Cannon, D. M., Caseras, X., Dandash, O., Dannlowski, U., Delvecchio, G., Diaz-Zuluaga, A. M., van Erp, T. G. M., Fatjo-Vilas, M., Foley, S. F., Forster, K., Fullerton, J. M., Goikolea, J. M., Grotegerd, D., Gruber, O., Haarman, B. C. M., Haatveit, B., Hajek, T., Hallahan, B., Harris, M., Hawkins, E. L., Howells, F. M., Hulsmann, C., Jahanshad, N., Jorgensen, K. N., Kircher, T., Kramer, B., Krug, A., Kuplicki, R., Lagerberg, T. V., Lancaster, T. M., Lenroot, R. K., Lonning, V., Lopez-Jaramillo, C., Malt, U. F., Mcdonald, C., Mcintosh, A. M., Mcphilemy, G., van der Meer, D., Melle, I., Melloni, E. M. T., Mitchell, P. B., Nabulsi, L., Nenadic, I., Oertel, V., Oldani, L., Opel, N., Otaduy, M. C. G., Overs, B. J., Pineda-Zapata, J. A., Pomarol-Clotet, E., Radua, J., Rauer, L., Redlich, R., Repple, J., Rive, M. M., Roberts, G., Ruhe, H. G., Salminen, L. E., Salvador, R., Sarro, S., Savitz, J., Schene, A. H., Sim, K., Soeiro-de-Souza, M. G., Stablein, M., Stein, D. J., Stein, F., Tamnes, C. K., Temmingh, H. S., Thomopoulos, S. I., Veltman, D. J., Vieta, E., Waltemate, L., Westlye, L. T., Whalley, H. C., Samann, P. G., Thompson, P. M., Ching, C. R. K., Andreassen, O. A., Agartz, I., Clinical Cognitive Neuropsychiatry Research Program (CCNP), Psychiatry, Anatomy and neurosciences, Amsterdam Neuroscience - Brain Imaging, Amsterdam Neuroscience - Compulsivity, Impulsivity & Attention, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, and Adult Psychiatry

Subjects
structural brain MRI, Bipolar Disorder, HALOPERIDOL, hippocampus, Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13], SEGMENTATION, Hippocampus, Hippocampal formation, 0302 clinical medicine, SCHIZOPHRENIA, Manic-depressive illness, psychosis, BRAIN, Research Articles, Trastorn bipolar, Radiological and Ultrasound Technology, 05 social sciences, Subiculum, ATLAS, Magnetic Resonance Imaging, Liti, 3. Good health, medicine.anatomical_structure, Neurology, Schizophrenia, lithium, Anatomy, Hippocampus (Brain), Research Article, MRI, INTERNEURONS, Psychosis, Hipocamp (Cervell), Neuroimaging, Amygdala, 050105 experimental psychology, CELL-PROLIFERATION, 03 medical and health sciences, Genetics, medicine, Humans, 0501 psychology and cognitive sciences, Radiology, Nuclear Medicine and imaging, Bipolar disorder, large‐scale, LITHIUM-TREATED PATIENTS, business.industry, Dentate gyrus, medicine.disease, nervous system, DENTATE GYRUS, large-scale, bipolar disorder subtype, Neurology (clinical), business, Neuroscience, 030217 neurology & neurosurgery
Abstract

The hippocampus consists of anatomically and functionally distinct subfields that may be differentially involved in the pathophysiology of bipolar disorder (BD). Here we, the Enhancing NeuroImaging Genetics through Meta‐Analysis Bipolar Disorder workinggroup, study hippocampal subfield volumetry in BD. T1‐weighted magnetic resonance imaging scans from 4,698 individuals (BD = 1,472, healthy controls [HC] = 3,226) from 23 sites worldwide were processed with FreeSurfer. We used linear mixed‐effects models and mega‐analysis to investigate differences in hippocampal subfield volumes between BD and HC, followed by analyses of clinical characteristics and medication use. BD showed significantly smaller volumes of the whole hippocampus (Cohen's d = −0.20), cornu ammonis (CA)1 (d = −0.18), CA2/3 (d = −0.11), CA4 (d = −0.19), molecular layer (d = −0.21), granule cell layer of dentate gyrus (d = −0.21), hippocampal tail (d = −0.10), subiculum (d = −0.15), presubiculum (d = −0.18), and hippocampal amygdala transition area (d = −0.17) compared to HC. Lithium users did not show volume differences compared to HC, while non‐users did. Antipsychotics or antiepileptic use was associated with smaller volumes. In this largest study of hippocampal subfields in BD to date, we show widespread reductions in nine of 12 subfields studied. The associations were modulated by medication use and specifically the lack of differences between lithium users and HC supports a possible protective role of lithium in BD., The hippocampus consists of anatomically and functionally distinct subfields that may be differentially involved in the pathophysiology of bipolar disorder.In the largest study of hippocampal subfields in bipolar disorder to date, from 23 sites worldwide, we report widespread reductions in nine of 12 subfields.The lack of differences between lithium users and healthy controls supports a possible protective role of lithium in bipolar disorder.

Published
2022

9. Cortical and subcortical brain structure in generalized anxiety disorder

Author

Paolo Brambilla, Tali M. Ball, Dan J. Stein, Courtney A. Filippi, Kathryn E. Werwath, Pedro Mario Pan, Heidi K. Schroeder, Hannah Zwiebel, Andrea Parolin Jackowski, Jared A. Nielsen, Savannah N. Gosnell, Hans J. Grabe, Christian Grillon, Paul M. Thompson, Gabrielle F. Freitag, Murray B. Stein, Karina S. Blair, Narcís Cardoner, Neda Jahanshad, Ana Munjiza Jovanovic, Cristina Ottaviani, Massimo Filippi, André Zugman, Katharina Wittfeld, Antonia N. Kaczkurkin, Camilla Cividini, Hugo D. Critchley, Nynke A. Groenewold, Elise M. Cardinale, Moji Aghajani, Bianca A.V. Alberton, Michael T. Perino, Anderson M. Winkler, Ellen Leibenluft, Sophia I. Thomopoulos, Mohammed R. Milad, Kevin Hilbert, Matteo Mancini, Randy L. Buckner, Henry Völzke, Robin Bülow, Carmen Andreescu, Milutin Kostić, Raquel E. Gur, Benson Mwangi, Daniel Porta-Casteràs, Michael J. Myers, Federica Agosta, Thomas Straube, Giovana Zunta-Soares, Gretchen J. Diefenbach, Martin P. Paulus, Erica Tamburo, Brenda E. Benson, Elena Makovac, Grace V. Ringlein, Andrea L. Gold, David Hofmann, Mon-Ju Wu, Jeffrey R. Strawn, Janna Marie Bas-Hoogendam, Dick J. Veltman, Eleonora Maggioni, Sandra Van der Auwera, Gregory A. Fonzo, Ramiro Salas, Giovanni Abrahão Salum, Daniel S. Pine, Gisele Gus Manfro, Bart Larsen, Monique Ernst, Nic J.A. van der Wee, Helena van Nieuwenhuizen, Mira Z. Hammoud, Ruben C. Gur, Katie L. Burkhouse, Chad M. Sylvester, Rachel Berta, Elisa Canu, Jair C. Soares, Theodore D. Satterthwaite, Qiongru Yu, Frances Meeten, Ulrike Lueken, Jordan W. Smoller, Michal Assaf, Lilianne R. Mujica-Parodi, K. Luan Phan, Jennifer Harper, Nicholas L. Balderston, James R. Blair, Anita Harrewijn, Rebecca B. Price, Katja Beesdo-Baum, Psychiatry, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Anatomy and neurosciences, Amsterdam Neuroscience - Brain Imaging, Harrewijn, A., Cardinale, E. M., Groenewold, N. A., Bas-Hoogendam, J. M., Aghajani, M., Hilbert, K., Cardoner, N., Porta-Casteras, D., Gosnell, S., Salas, R., Jackowski, A. P., Pan, P. M., Salum, G. A., Blair, K. S., Blair, J. R., Hammoud, M. Z., Milad, M. R., Burkhouse, K. L., Phan, K. L., Schroeder, H. K., Strawn, J. R., Beesdo-Baum, K., Jahanshad, N., Thomopoulos, S. I., Buckner, R., Nielsen, J. A., Smoller, J. W., Soares, J. C., Mwangi, B., Wu, M. -J., Zunta-Soares, G. B., Assaf, M., Diefenbach, G. J., Brambilla, P., Maggioni, E., Hofmann, D., Straube, T., Andreescu, C., Berta, R., Tamburo, E., Price, R. B., Manfro, G. G., Agosta, F., Canu, E., Cividini, C., Filippi, M., Kostic, M., Munjiza Jovanovic, A., Alberton, B. A. V., Benson, B., Freitag, G. F., Filippi, C. A., Gold, A. L., Leibenluft, E., Ringlein, G. V., Werwath, K. E., Zwiebel, H., Zugman, A., Grabe, H. J., Van der Auwera, S., Wittfeld, K., Volzke, H., Bulow, R., Balderston, N. L., Ernst, M., Grillon, C., Mujica-Parodi, L. R., van Nieuwenhuizen, H., Critchley, H. D., Makovac, E., Mancini, M., Meeten, F., Ottaviani, C., Ball, T. M., Fonzo, G. A., Paulus, M. P., Stein, M. B., Gur, R. E., Gur, R. C., Kaczkurkin, A. N., Larsen, B., Satterthwaite, T. D., Harper, J., Myers, M., Perino, M. T., Sylvester, C. M., Yu, Q., Lueken, U., Veltman, D. J., Thompson, P. M., Stein, D. J., Van der Wee, N. J. A., Winkler, A. M., and Pine, D. S.

Subjects
Adult, Male, medicine.medical_specialty, endocrine system, Generalized anxiety disorder, Neurosciences. Biological psychiatry. Neuropsychiatry, Anxiety, Audiology, Article, Structural magnetic resonance imaging, Cellular and Molecular Neuroscience, Secondary analysis, medicine, Psychology, Humans, ddc:610, Cortical surface, generalized anxiety disorder, structural brain imaging, cortical thickness, Child, diagnostic imaging [Brain], Biological Psychiatry, Medication use, diagnostic imaging [Anxiety Disorders], medicine.diagnostic_test, business.industry, Brain, Small sample, Magnetic resonance imaging, medicine.disease, Magnetic Resonance Imaging, Anxiety Disorders, Psychiatry and Mental health, multicentric network, Female, medicine.symptom, business, RC321-571, Neuroscience
Abstract

The goal of this study was to compare brain structure between individuals with generalized anxiety disorder (GAD) and healthy controls. Previous studies have generated inconsistent findings, possibly due to small sample sizes, or clinical/analytic heterogeneity. To address these concerns, we combined data from 28 research sites worldwide through the ENIGMA-Anxiety Working Group, using a single, pre-registered mega-analysis. Structural magnetic resonance imaging data from children and adults (5–90 years) were processed using FreeSurfer. The main analysis included the regional and vertex-wise cortical thickness, cortical surface area, and subcortical volume as dependent variables, and GAD, age, age-squared, sex, and their interactions as independent variables. Nuisance variables included IQ, years of education, medication use, comorbidities, and global brain measures. The main analysis (1020 individuals with GAD and 2999 healthy controls) included random slopes per site and random intercepts per scanner. A secondary analysis (1112 individuals with GAD and 3282 healthy controls) included fixed slopes and random intercepts per scanner with the same variables. The main analysis showed no effect of GAD on brain structure, nor interactions involving GAD, age, or sex. The secondary analysis showed increased volume in the right ventral diencephalon in male individuals with GAD compared to male healthy controls, whereas female individuals with GAD did not differ from female healthy controls. This mega-analysis combining worldwide data showed that differences in brain structure related to GAD are small, possibly reflecting heterogeneity or those structural alterations are not a major component of its pathophysiology.

Published
2021

10. Virtual Histology of Cortical Thickness and Shared Neurobiology in 6 Psychiatric Disorders

Author

Committee, Writing, Disorder, Autism Spectrum, French, Leon, Grevet, Eugenio H, Groenewold, Nynke A, Grotegerd, Dominik, Gruber, Oliver, Gruner, Patricia, Guerrero-Pedraza, Amalia, Gur, Raquel E, Gur, Ruben C, Haar, Shlomi, Haarman, Bartholomeus C M, Thomopoulos, Sophia I, Haavik, Jan, Hahn, Tim, Hajek, Tomas, Harrison, Benjamin J, Harrison, Neil A, Hartman, Catharina A, Whalley, Heather C, Heslenfeld, Dirk J, Hibar, Derrek P, Hilland, Eva, Pozzi, Elena, Hirano, Yoshiyuki, Ho, Tiffany C, Hoekstra, Pieter J, Hoekstra, Liesbeth, Hohmann, Sarah, Hong, L. E., Höschl, Cyril, Høvik, Marie F, Howells, Fleur M, Nenadic, Igor, Abe, Yoshinari, Jalbrzikowski, Maria, James, Anthony C, Janssen, Joost, Jaspers-Fayer, Fern, Xu, Jian, Jonassen, Rune, Karkashadze, Georgii, King, Joseph A, Kircher, Tilo, Kirschner, Matthias, Abé, Christoph, Koch, Kathrin, Kochunov, Peter, Kohls, Gregor, Konrad, Kerstin, Krämer, Bernd, Krug, Axel, Kuntsi, Jonna, Kwon, Jun Soo, Landén, Mikael, Landrø, Nils I, Anticevic, Alan, Lazaro, Luisa, Lebedeva, Irina S, Leehr, Elisabeth J, Lera-Miguel, Sara, Lesch, Klaus-Peter, Lochner, Christine, Louza, Mario R, Luna, Beatriz, Lundervold, Astri J, MacMaster, Frank P, Alda, Martin, Maglanoc, Luigi A, Malpas, Charles B, Portella, Maria J, Marsh, Rachel, Martyn, Fiona M, Mataix-Cols, David, Mathalon, Daniel H, McCarthy, Hazel, McDonald, Colm, McPhilemy, Genevieve, Aleman, Andre, Meinert, Susanne, Menchón, José M, Minuzzi, Luciano, Mitchell, Philip B, Moreno, Carmen, Morgado, Pedro, Muratori, Filippo, Murphy, Clodagh M, Murphy, Declan, Mwangi, Benson, Alloza, Clara, Nabulsi, Leila, Nakagawa, Akiko, Nakamae, Takashi, Namazova, Leyla, Narayanaswamy, Janardhanan, Jahanshad, Neda, Nguyen, Danai D, Nicolau, Rosa, O'Gorman Tuura, Ruth L, O'Hearn, Kirsten, Alonso-Lana, Silvia, Oosterlaan, Jaap, Opel, Nils, Ophoff, Roel A, Oranje, Bob, García de la Foz, Victor Ortiz, Overs, Bronwyn J, Paloyelis, Yannis, Pantelis, Christos, Parellada, Mara, Pauli, Paul, Disorder, Bipolar, Ameis, Stephanie H, Picó-Pérez, Maria, Picon, Felipe A, Piras, Fabrizio, Piras, Federica, Plessen, Kerstin J, Pomarol-Clotet, Edith, Preda, Adrian, Puig, Olga, Quidé, Yann, Radua, Joaquim, Anagnostou, Evdokia, Ramos-Quiroga, J Antoni, Rasser, Paul E, Rauer, Lisa, Reddy, Janardhan, Redlich, Ronny, Reif, Andreas, Reneman, Liesbeth, Repple, Jonathan, Retico, Alessandra, Richarte, Vanesa, McIntosh, Andrew A, Richter, Anja, Rosa, Pedro G P, Rubia, Katya K, Hashimoto, Ryota, Sacchet, Matthew D, Salvador, Raymond, Santonja, Javier, Sarink, Kelvin, Sarró, Salvador, Satterthwaite, Theodore D, Arango, Celso, Sawa, Akira, Schall, Ulrich, Schofield, Peter R, Schrantee, Anouk, Seitz, Jochen, Serpa, Mauricio H, Setién-Suero, Esther, Shaw, Philip, Shook, Devon, Silk, Tim J, Arnold, Paul D, Sim, Kang, Simon, Schmitt, Simpson, Helen Blair, Singh, Aditya, Skoch, Antonin, Skokauskas, Norbert, Soares, Jair C, Soreni, Noam, Soriano-Mas, Carles, Spalletta, Gianfranco, Asherson, Philip, Spaniel, Filip, Lawrie, Stephen M, Stern, Emily R, Stewart, S Evelyn, Takayanagi, Yoichiro, Temmingh, Henk S, Tolin, David F, Tomecek, David, Tordesillas-Gutiérrez, Diana, Tosetti, Michela, Assogna, Francesca, Uhlmann, Anne, van Amelsvoort, Therese, van der Wee, Nic J A, van der Werff, Steven J A, van Haren, Neeltje E M, van Wingen, Guido A, Vance, Alasdair, Vázquez-Bourgon, Javier, Vecchio, Daniela, Venkatasubramanian, Ganesan, Auzias, Guillaume, Vieta, Eduard, Vilarroya, Oscar, Vives-Gilabert, Yolanda, Voineskos, Aristotle N, Völzke, Henry, von Polier, Georg G, Walton, Esther, Weickert, Thomas W, Weickert, Cynthia Shannon, Weideman, Andrea S, Ayesa-Arriola, Rosa, Wittfeld, Katharina, Wolf, Daniel H, Wu, Mon-Ju, Yang, T. T., Yang, Sikun, Yoncheva, Yuliya, Yun, Je-Yeon, Cheng, Yuqi, Zanetti, Marcus V, Ziegler, Georg C, Bakker, Geor, Franke, Barbara, Hoogman, Martine, Buitelaar, Jan K, van Rooij, Daan, Andreassen, Ole A, Ching, Christopher R K, Veltman, Dick J, Schmaal, Lianne, Stein, Dan J, van den Heuvel, Odile A, Disorder, Major Depressive, Banaj, Nerisa, Turner, Jessica A, van Erp, Theo G M, Pausova, Zdenka, Thompson, Paul M, Paus, Tomáš, Attention-Deficit/Hyperactivity Disorder, Banaschewski, Tobias, Bandeira, Cibele E, Baranov, Alexandr, Bargalló, Núria, Bau, Claiton H D, Baumeister, Sarah, Baune, Bernhard T, Bellgrove, Mark A, Benedetti, Francesco, Disorder, Obsessive-Compulsive, Bertolino, Alessandro, Boedhoe, Premika S W, Boks, Marco, Bollettini, Irene, Del Mar Bonnin, Caterina, Borgers, Tiana, Borgwardt, Stefan, Brandeis, Daniel, Brennan, Brian P, Bruggemann, Jason M, Groups, Schizophrenia ENIGMA Working, Bülow, Robin, Busatto, Geraldo F, Calderoni, Sara, Calhoun, Vince D, Calvo, Rosa, Canales-Rodríguez, Erick J, Cannon, Dara M, Carr, Vaughan J, Cascella, Nicola, Cercignani, Mara, Patel, Yash, Chaim-Avancini, Tiffany M, Christakou, Anastasia, Coghill, David, Conzelmann, Annette, Crespo-Facorro, Benedicto, Cubillo, Ana I, Cullen, Kathryn R, Cupertino, Renata B, Daly, Eileen, Dannlowski, Udo, Parker, Nadine, Davey, Christopher G, Denys, Damiaan, Deruelle, Christine, Di Giorgio, Annabella, Dickie, Erin W, Dima, Danai, Dohm, Katharina, Ehrlich, Stefan, Ely, Benjamin A, Erwin-Grabner, Tracy, Shin, Jean, Ethofer, Thomas, Fair, Damien A, Fallgatter, Andreas, Faraone, Stephen V, Fatjó-Vilas, Mar, Fedor, Jennifer M, Fitzgerald, Kate D, Ford, Judith M, Frodl, Thomas, Fu, Cynthia H Y, Howard, Derek, Fullerton, Janice M, Gabel, Matt C, Glahn, David C, Roberts, Gloria, Gogberashvili, Tinatin, Goikolea, Jose M, Gotlib, Ian H, Goya-Maldonado, Roberto, Grabe, Hans, Green, Melissa J, Patel, Y., Parker, N., Shin, J., Howard, D., French, L., Thomopoulos, S. I., Pozzi, E., Abe, Y., Abe, C., Anticevic, A., Alda, M., Aleman, A., Alloza, C., Alonso-Lana, S., Ameis, S. H., Anagnostou, E., Mcintosh, A. A., Arango, C., Arnold, P. D., Asherson, P., Assogna, F., Auzias, G., Ayesa-Arriola, R., Bakker, G., Banaj, N., Banaschewski, T., Bandeira, C. E., Baranov, A., Bargallo, N., Bau, C. H. D., Baumeister, S., Baune, B. T., Bellgrove, M. A., Benedetti, F., Bertolino, A., Boedhoe, P. S. W., Boks, M., Bollettini, I., Del Mar Bonnin, C., Borgers, T., Borgwardt, S., Brandeis, D., Brennan, B. P., Bruggemann, J. M., Bulow, R., Busatto, G. F., Calderoni, S., Calhoun, V. D., Calvo, R., Canales-Rodriguez, E. J., Cannon, D. M., Carr, V. J., Cascella, N., Cercignani, M., Chaim-Avancini, T. M., Christakou, A., Coghill, D., Conzelmann, A., Crespo-Facorro, B., Cubillo, A. I., Cullen, K. R., Cupertino, R. B., Daly, E., Dannlowski, U., Davey, C. G., Denys, D., Deruelle, C., Di Giorgio, A., Dickie, E. W., Dima, D., Dohm, K., Ehrlich, S., Ely, B. A., Erwin-Grabner, T., Ethofer, T., Fair, D. A., Fallgatter, A. J., Faraone, S. V., Fatjo-Vilas, M., Fedor, J. M., Fitzgerald, K. D., Ford, J. M., Frodl, T., Fu, C. H. Y., Fullerton, J. M., Gabel, M. C., Glahn, D. C., Roberts, G., Gogberashvili, T., Goikolea, J. M., Gotlib, I. H., Goya-Maldonado, R., Grabe, H. J., Green, M. J., Grevet, E. H., Groenewold, N. A., Grotegerd, D., Gruber, O., Gruner, P., Guerrero-Pedraza, A., Gur, R. E., Gur, R. C., Haar, S., Haarman, B. C. M., Haavik, J., Hahn, T., Hajek, T., Harrison, B. J., Harrison, N. A., Hartman, C. A., Whalley, H. C., Heslenfeld, D. J., Hibar, D. P., Hilland, E., Hirano, Y., Ho, T. C., Hoekstra, P. J., Hoekstra, L., Hohmann, S., Hong, L. E., Hoschl, C., Hovik, M. F., Howells, F. M., Nenadic, I., Jalbrzikowski, M., James, A. C., Janssen, J., Jaspers-Fayer, F., Xu, J., Jonassen, R., Karkashadze, G., King, J. A., Kircher, T., Kirschner, M., Koch, K., Kochunov, P., Kohls, G., Konrad, K., Kramer, B., Krug, A., Kuntsi, J., Kwon, J. S., Landen, M., Landro, N. I., Lazaro, L., Lebedeva, I. S., Leehr, E. J., Lera-Miguel, S., Lesch, K. -P., Lochner, C., Louza, M. R., Luna, B., Lundervold, A. J., Macmaster, F. P., Maglanoc, L. A., Malpas, C. B., Portella, M. J., Marsh, R., Martyn, F. M., Mataix-Cols, D., Mathalon, D. H., Mccarthy, H., Mcdonald, C., Mcphilemy, G., Meinert, S., Menchon, J. M., Minuzzi, L., Mitchell, P. B., Moreno, C., Morgado, P., Muratori, F., Murphy, C. M., Murphy, D., Mwangi, B., Nabulsi, L., Nakagawa, A., Nakamae, T., Namazova, L., Narayanaswamy, J., Jahanshad, N., Nguyen, D. D., Nicolau, R., O'Gorman Tuura, R. L., O'Hearn, K., Oosterlaan, J., Opel, N., Ophoff, R. A., Oranje, B., Garcia De La Foz, V. O., Overs, B. J., Paloyelis, Y., Pantelis, C., Parellada, M., Pauli, P., Pico-Perez, M., Picon, F. A., Piras, F., Plessen, K. J., Pomarol-Clotet, E., Preda, A., Puig, O., Quide, Y., Radua, J., Ramos-Quiroga, J. A., Rasser, P. E., Rauer, L., Reddy, J., Redlich, R., Reif, A., Reneman, L., Repple, J., Retico, A., Richarte, V., Richter, A., Rosa, P. G. P., Rubia, K. K., Hashimoto, R., Sacchet, M. D., Salvador, R., Santonja, J., Sarink, K., Sarro, S., Satterthwaite, T. D., Sawa, A., Schall, U., Schofield, P. R., Schrantee, A., Seitz, J., Serpa, M. H., Setien-Suero, E., Shaw, P., Shook, D., Silk, T. J., Sim, K., Simon, S., Simpson, H. B., Singh, A., Skoch, A., Skokauskas, N., Soares, J. C., Soreni, N., Soriano-Mas, C., Spalletta, G., Spaniel, F., Lawrie, S. M., Stern, E. R., Stewart, S. E., Takayanagi, Y., Temmingh, H. S., Tolin, D. F., Tomecek, D., Tordesillas-Gutierrez, D., Tosetti, M., Uhlmann, A., Van Amelsvoort, T., Van Der Wee, N. J. A., Van Der Werff, S. J. A., Van Haren, N. E. M., Van Wingen, G. A., Vance, A., Vazquez-Bourgon, J., Vecchio, D., Venkatasubramanian, G., Vieta, E., Vilarroya, O., Vives-Gilabert, Y., Voineskos, A. N., Volzke, H., Von Polier, G. G., Walton, E., Weickert, T. W., Weickert, C. S., Weideman, A. S., Wittfeld, K., Wolf, D. H., Wu, M. -J., Yang, T. T., Yang, K., Yoncheva, Y., Yun, J. -Y., Cheng, Y., Zanetti, M. V., Ziegler, G. C., Franke, B., Hoogman, M., Buitelaar, J. K., Van Rooij, D., Andreassen, O. A., Ching, C. R. K., Veltman, D. J., Schmaal, L., Stein, D. J., Van Den Heuvel, O. A., Turner, J. A., Van Erp, T. G. M., Pausova, Z., Thompson, P. M., Paus, T., Institut de Neurosciences de la Timone (INT), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Pediatric surgery, Radiology and nuclear medicine, Anatomy and neurosciences, Psychiatry, Amsterdam Neuroscience - Brain Imaging, Amsterdam Neuroscience - Compulsivity, Impulsivity & Attention, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Amsterdam Neuroscience - Neurodegeneration, Psychiatrie & Neuropsychologie, RS: MHeNs - R2 - Mental Health, MUMC+: MA Med Staf Spec Psychiatrie (9), Adult Psychiatry, ANS - Compulsivity, Impulsivity & Attention, General Paediatrics, ARD - Amsterdam Reproduction and Development, Radiology and Nuclear Medicine, APH - Personalized Medicine, ANS - Brain Imaging, ANS - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Mental Health, University of Zurich, Clinical Cognitive Neuropsychiatry Research Program (CCNP), Clinical Neuropsychology, Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Child and Adolescent Psychiatry / Psychology, IBBA, and Cognitive Psychology

Subjects
Male, Obsessive-Compulsive Disorder, Bipolar Disorder, Autism Spectrum Disorder, Autism, [SDV]Life Sciences [q-bio], Gene Expression, cytology [Cerebral Cortex], Cohort Studies, Fetal Development, physiology [Gene Expression], 2738 Psychiatry and Mental Health, 0302 clinical medicine, diagnostic imaging [Cerebral Cortex], SCHIZOPHRENIA, BRAIN, Child, Obsessive-compulsive disorder (OCD), Original Investigation, Aged, 80 and over, Cerebral Cortex, 0303 health sciences, pathology [Depressive Disorder, Major], Principal Component Analysis, Adolescent psychiatry, 10058 Department of Child and Adolescent Psychiatry, Middle Aged, diagnostic imaging [Obsessive-Compulsive Disorder], REGIONS, Magnetic Resonance Imaging, 3. Good health, FALSE DISCOVERY RATE, Psychiatry and Mental health, Autism spectrum disorder, Schizophrenia, growth & development [Cerebral Cortex], Child, Preschool, Major depressive disorder, diagnostic imaging [Schizophrenia], Esquizofrènia, Female, Psiquiatria infantil, Psiquiatria de l'adolescència, diagnostic imaging [Autism Spectrum Disorder], Adult, medicine.medical_specialty, Adolescent, Human Development, 610 Medicine & health, diagnostic imaging [Bipolar Disorder], pathology [Autism Spectrum Disorder], diagnostic imaging [Depressive Disorder, Major], 03 medical and health sciences, Young Adult, All institutes and research themes of the Radboud University Medical Center, Neuroimaging, SDG 3 - Good Health and Well-being, CEREBRAL-CORTEX, Child psychiatry, medicine, Attention deficit hyperactivity disorder, Humans, Bipolar disorder, ddc:610, Psychiatry, pathology [Schizophrenia], 030304 developmental biology, Aged, Depressive Disorder, Major, Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7], business.industry, DENDRITE, Computational Biology, Correction, pathology [Attention Deficit Disorder with Hyperactivity], physiology [Fetal Development], medicine.disease, PATHOLOGY, pathology [Bipolar Disorder], pathology [Obsessive-Compulsive Disorder], 10036 Medical Clinic, Attention Deficit Disorder with Hyperactivity, 10054 Clinic for Psychiatry, Psychotherapy, and Psychosomatics, Case-Control Studies, DENSITY, ORIGINS, HIPPOCAMPUS, diagnostic imaging [Attention Deficit Disorder with Hyperactivity], pathology [Cerebral Cortex], Autisme, business, Neuroscience, 030217 neurology & neurosurgery, physiology [Human Development]
Abstract

[Importance] Large-scale neuroimaging studies have revealed group differences in cortical thickness across many psychiatric disorders. The underlying neurobiology behind these differences is not well understood., [Objective] To determine neurobiologic correlates of group differences in cortical thickness between cases and controls in 6 disorders: attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), bipolar disorder (BD), major depressive disorder (MDD), obsessive-compulsive disorder (OCD), and schizophrenia., [Design, Setting, and Participants] Profiles of group differences in cortical thickness between cases and controls were generated using T1-weighted magnetic resonance images. Similarity between interregional profiles of cell-specific gene expression and those in the group differences in cortical thickness were investigated in each disorder. Next, principal component analysis was used to reveal a shared profile of group difference in thickness across the disorders. Analysis for gene coexpression, clustering, and enrichment for genes associated with these disorders were conducted. Data analysis was conducted between June and December 2019. The analysis included 145 cohorts across 6 psychiatric disorders drawn from the ENIGMA consortium. The numbers of cases and controls in each of the 6 disorders were as follows: ADHD: 1814 and 1602; ASD: 1748 and 1770; BD: 1547 and 3405; MDD: 2658 and 3572; OCD: 2266 and 2007; and schizophrenia: 2688 and 3244., [Main Outcomes and Measures] Interregional profiles of group difference in cortical thickness between cases and controls., [Results] A total of 12 721 cases and 15 600 controls, ranging from ages 2 to 89 years, were included in this study. Interregional profiles of group differences in cortical thickness for each of the 6 psychiatric disorders were associated with profiles of gene expression specific to pyramidal (CA1) cells, astrocytes (except for BD), and microglia (except for OCD); collectively, gene-expression profiles of the 3 cell types explain between 25% and 54% of variance in interregional profiles of group differences in cortical thickness. Principal component analysis revealed a shared profile of difference in cortical thickness across the 6 disorders (48% variance explained); interregional profile of this principal component 1 was associated with that of the pyramidal-cell gene expression (explaining 56% of interregional variation). Coexpression analyses of these genes revealed 2 clusters: (1) a prenatal cluster enriched with genes involved in neurodevelopmental (axon guidance) processes and (2) a postnatal cluster enriched with genes involved in synaptic activity and plasticity-related processes. These clusters were enriched with genes associated with all 6 psychiatric disorders., [Conclusions and Relevance] In this study, shared neurobiologic processes were associated with differences in cortical thickness across multiple psychiatric disorders. These processes implicate a common role of prenatal development and postnatal functioning of the cerebral cortex in these disorders.

Published
2021

11. An overview of the first 5 years of the ENIGMA obsessive-compulsive disorder working group: The power of worldwide collaboration

Author

Edna Grünblatt, Noam Soreni, Takashi Nakamae, Susanne Walitza, Anthony A. James, Paul D. Arnold, Iliyan Ivanov, Patricia Gruner, Janardhanan C. Narayanaswamy, Dick J. Veltman, Gianfranco Spalletta, Sara Bertolín, H. Blair Simpson, Tomohiro Nakao, Je-Yeon Yun, David Mataix-Cols, Gerd Kvale, Carles Soriano-Mas, Guido van Wingen, Ganesan Venkatasubramanian, Luisa Lázaro, Francesco Benedetti, Chris Vriend, Xiangzhen Kong, Jan C. Beucke, Kate D. Fitzgerald, Martine Hoogman, Y. C.Janardhan Reddy, Kathrin Koch, Daan van Rooij, Jun Soo Kwon, David F. Tolin, Rachel Marsh, Jan K. Buitelaar, Neda Jahanshad, Christopher Pittenger, Stephan F. Taylor, Tomáš Paus, Willem B Bruin, Clyde Francks, Anushree Bose, Chaim Huyser, Christine Lochner, Erika L. Nurmi, Dan J. Stein, Joseph O'Neill, S. Evelyn Stewart, Yash Patel, João Ricardo Sato, Zhen Wang, Irene Bollettini, Lianne Schmaal, Alessandro S. De Nadai, Fabrizio Piras, Yoshiyuki Hirano, Brian P. Brennan, Odile A. van den Heuvel, Pedro Morgado, Sophia I. Thomopoulos, Marcelo Q. Hoexter, Premika S.W. Boedhoe, Paul M. Thompson, van den Heuvel, O. A., Boedhoe, P. S. W., Bertolin, S., Bruin, W. B., Francks, C., Ivanov, I., Jahanshad, N., Kong, X. -Z., Kwon, J. S., O'Neill, J., Paus, T., Patel, Y., Piras, F., Schmaal, L., Soriano-Mas, C., Spalletta, G., van Wingen, G. A., Yun, J. -Y., Vriend, C., Simpson, H. B., van Rooij, D., Hoexter, M. Q., Hoogman, M., Buitelaar, J. K., Arnold, P., Beucke, J. C., Benedetti, F., Bollettini, I., Bose, A., Brennan, B. P., De Nadai, A. S., Fitzgerald, K., Gruner, P., Grunblatt, E., Hirano, Y., Huyser, C., James, A., Koch, K., Kvale, G., Lazaro, L., Lochner, C., Marsh, R., Mataix-Cols, D., Morgado, P., Nakamae, T., Nakao, T., Narayanaswamy, J. C., Nurmi, E., Pittenger, C., Reddy, Y. C. J., Sato, J. R., Soreni, N., Stewart, S. E., Taylor, S. F., Tolin, D., Thomopoulos, S. I., Veltman, D. J., Venkatasubramanian, G., Walitza, S., Wang, Z., Thompson, P. M., and Stein, D. J.

Subjects
mega-analysis, Obsessive-Compulsive Disorder, Review Article, Machine Learning, 0302 clinical medicine, Neurobiology, Obsessive-compulsive disorder, Multicenter Studies as Topic, Disease process, Cervell, Review Articles, Pediatric, Psychiatry, Cerebral Cortex, Collaborative community, Radiological and Ultrasound Technology, 05 social sciences, ENIGMA, Brain, Experimental Psychology, Serious Mental Illness, humanities, 3. Good health, Mental Health, Neurology, Meta-analysis, Neurological, Cognitive Sciences, Mega analysis, Anatomy, Psychology, Neurobiologia, Clinical psychology, MRI, ENIGMA-OCD working group, Neuroimaging, behavioral disciplines and activities, 050105 experimental psychology, Lateralization of brain function, Power (social and political), 03 medical and health sciences, obsessive–compulsive disorder, Obsessive compulsive, Clinical Research, mental disorders, Humans, 0501 psychology and cognitive sciences, Radiology, Nuclear Medicine and imaging, Psiquiatria, mega‐analysis, volume, Neurosi obsessiva, Neurosciences, surface area, cortical thickness, Brain Disorders, meta-analysis, meta‐analysis, Neurology (clinical), 030217 neurology & neurosurgery
Abstract

Neuroimaging has played an important part in advancing our understanding of the neurobiology of obsessive?compulsive disorder (OCD). At the same time, neuroimaging studies of OCD have had notable limitations, including reliance on relatively small samples. International collaborative efforts to increase statistical power by combining samples from across sites have been bolstered by the ENIGMA consortium; this provides specific technical expertise for conducting multi-site analyses, as well as access to a collaborative community of neuroimaging scientists. In this article, we outline the background to, development of, and initial findings from ENIGMA's OCD working group, which currently consists of 47 samples from 34 institutes in 15 countries on 5 continents, with a total sample of 2,323 OCD patients and 2,325 healthy controls. Initial work has focused on studies of cortical thickness and subcortical volumes, structural connectivity, and brain lateralization in children, adolescents and adults with OCD, also including the study on the commonalities and distinctions across different neurodevelopment disorders. Additional work is ongoing, employing machine learning techniques. Findings to date have contributed to the development of neurobiological models of OCD, have provided an important model of global scientific collaboration, and have had a number of clinical implications. Importantly, our work has shed new light on questions about whether structural and functional alterations found in OCD reflect neurodevelopmental changes, effects of the disease process, or medication impacts. We conclude with a summary of ongoing work by ENIGMA-OCD, and a consideration of future directions for neuroimaging research on OCD within and beyond ENIGMA.

Published
2020

12. Large-scale analysis of structural brain asymmetries during neurodevelopment: Associations with age and sex in 4265 children and adolescents.

Author

Kurth F, Schijven D, van den Heuvel OA, Hoogman M, van Rooij D, Stein DJ, Buitelaar JK, Bölte S, Auzias G, Kushki A, Venkatasubramanian G, Rubia K, Bollmann S, Isaksson J, Jaspers-Fayer F, Marsh R, Batistuzzo MC, Arnold PD, Bressan RA, Stewart SE, Gruner P, Sorensen L, Pan PM, Silk TJ, Gur RC, Cubillo AI, Haavik J, O'Gorman Tuura RL, Hartman CA, Calvo R, McGrath J, Calderoni S, Jackowski A, Chantiluke KC, Satterthwaite TD, Busatto GF, Nigg JT, Gur RE, Retico A, Tosetti M, Gallagher L, Szeszko PR, Neufeld J, Ortiz AE, Ghisleni C, Lazaro L, Hoekstra PJ, Anagnostou E, Hoekstra L, Simpson B, Plessen JK, Deruelle C, Soreni N, James A, Narayanaswamy J, Reddy JY, Fitzgerald J, Bellgrove MA, Salum GA, Janssen J, Muratori F, Vila M, Giral MG, Ameis SH, Bosco P, Remnélius KL, Huyser C, Pariente JC, Jalbrzikowski M, Rosa PG, O'Hearn KM, Ehrlich S, Mollon J, Zugman A, Christakou A, Arango C, Fisher SE, Kong X, Franke B, Medland SE, Thomopoulos SI, Jahanshad N, Glahn DC, Thompson PM, Francks C, and Luders E

Subjects
Humans, Adolescent, Male, Child, Female, Child, Preschool, Infant, Age Factors, Child Development physiology, Functional Laterality physiology, Adolescent Development physiology, Sex Characteristics, Magnetic Resonance Imaging, Brain diagnostic imaging, Brain growth & development, Brain anatomy & histology
Abstract

Only a small number of studies have assessed structural differences between the two hemispheres during childhood and adolescence. However, the existing findings lack consistency or are restricted to a particular brain region, a specific brain feature, or a relatively narrow age range. Here, we investigated associations between brain asymmetry and age as well as sex in one of the largest pediatric samples to date (n = 4265), aged 1-18 years, scanned at 69 sites participating in the ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) consortium. Our study revealed that significant brain asymmetries already exist in childhood, but their magnitude and direction depend on the brain region examined and the morphometric measurement used (cortical volume or thickness, regional surface area, or subcortical volume). With respect to effects of age, some asymmetries became weaker over time while others became stronger; sometimes they even reversed direction. With respect to sex differences, the total number of regions exhibiting significant asymmetries was larger in females than in males, while the total number of measurements indicating significant asymmetries was larger in males (as we obtained more than one measurement per cortical region). The magnitude of the significant asymmetries was also greater in males. However, effect sizes for both age effects and sex differences were small. Taken together, these findings suggest that cerebral asymmetries are an inherent organizational pattern of the brain that manifests early in life. Overall, brain asymmetry appears to be relatively stable throughout childhood and adolescence, with some differential effects in males and females., (© 2024 The Author(s). Human Brain Mapping published by Wiley Periodicals LLC.)

Published
2024
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