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1. A structural account of substrate and inhibitor specificity differences between two naphthol reductases

Author

Liao, Der-Ing, Thompson, Lames E., Fahnestock, Stephen, Valent, Barbara, and Jordan, Douglas B.

Subjects
Biochemistry -- Research, Melanin -- Physiological aspects, Biosynthesis -- Analysis, Fungi -- Physiological aspects, Biological sciences, Chemistry
Abstract

Research has been conducted on the short chain dehtydrogenase/reductases that mediate naphthol reduction reactions in the biosynthesis of fungal melanin. Results indicate that the C-terminal residues of the two naphthol reductases are the inhibitor and substrate specificity determinants.

Published
2001

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