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4 results on '"Tofazzal Hossain, Md."'

1. A novel virtual screening procedure identifies Pralatrexate as inhibitor of SARS-CoV-2 RdRp and it reduces viral replication in vitro

Author

Zhang, Haiping, primary, Yang, Yang, additional, Li, Junxin, additional, Wang, Min, additional, Saravanan, Konda Mani, additional, Wei, Jinli, additional, Tze-Yang Ng, Justin, additional, Tofazzal Hossain, Md., additional, Liu, Maoxuan, additional, Zhang, Huiling, additional, Ren, Xiaohu, additional, Pan, Yi, additional, Peng, Yin, additional, Shi, Yi, additional, Wan, Xiaochun, additional, Liu, Yingxia, additional, and Wei, Yanjie, additional

Published
2020
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4. Structural insight into the active site of a Bombyx moriunclassified glutathione transferase

Author

Tofazzal Hossain, MD. and Yamamoto, Kohji

Abstract

Glutathione transferases (GSTs) are major detoxification enzymes that play central roles in the defense against various environmental toxicants as well as oxidative stress. Here, we identify amino acid residues of an unclassified GST from Bombyx mori, bmGSTu-interacting glutathione (GSH). Site-directed mutagenesis of bmGSTu mutants indicated that amino acid residues Asp103, Ser162, and Ser166 contribute to catalytic activity.

Published
2015
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