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336 results on '"Tombolini, P."'

9. Reconstructing Nonlinear Dynamical Systems from Multi-Modal Time Series

Author

Kramer, Daniel, Bommer, Philine Lou, Tombolini, Carlo, Koppe, Georgia, and Durstewitz, Daniel

Subjects
Computer Science - Machine Learning, Quantitative Biology - Quantitative Methods, Statistics - Machine Learning
Abstract

Empirically observed time series in physics, biology, or medicine, are commonly generated by some underlying dynamical system (DS) which is the target of scientific interest. There is an increasing interest to harvest machine learning methods to reconstruct this latent DS in a data-driven, unsupervised way. In many areas of science it is common to sample time series observations from many data modalities simultaneously, e.g. electrophysiological and behavioral time series in a typical neuroscience experiment. However, current machine learning tools for reconstructing DSs usually focus on just one data modality. Here we propose a general framework for multi-modal data integration for the purpose of nonlinear DS reconstruction and the analysis of cross-modal relations. This framework is based on dynamically interpretable recurrent neural networks as general approximators of nonlinear DSs, coupled to sets of modality-specific decoder models from the class of generalized linear models. Both an expectation-maximization and a variational inference algorithm for model training are advanced and compared. We show on nonlinear DS benchmarks that our algorithms can efficiently compensate for too noisy or missing information in one data channel by exploiting other channels, and demonstrate on experimental neuroscience data how the algorithm learns to link different data domains to the underlying dynamics., Comment: 19 pages, 8 figures

Published
2021

12. Modelling the spread of Covid19 in Italy using a revised version of the SIR model

Author

Palladino, Andrea, Nardelli, Vincenzo, Atzeni, Luigi Giuseppe, Cantatore, Nane, Cataldo, Maddalena, Croccolo, Fabrizio, Estrada, Nicolas, and Tombolini, Antonio

Subjects
Physics - Physics and Society, Quantitative Biology - Populations and Evolution
Abstract

In this paper, we present a model to predict the spread of the Covid-19 epidemic and apply it to the specific case of Italy. We started from a simple Susceptible, Infected, Recovered (SIR) model and we added the condition that, after a certain time, the basic reproduction number $R_0$ exponentially decays in time, as empirically suggested by world data. Using this model, we were able to reproduce the real behavior of the epidemic with an average error of 5\%. Moreover, we illustrate possible future scenarios, associated to different intervals of $R_0$. This model has been used since the beginning of March 2020, predicting the Italian peak of the epidemic in April 2020 with about 100.000 detected active cases. The real peak of the epidemic happened on the 20th of April 2020, with 108.000 active cases. This result shows that the model had predictive power for the italian case., Comment: The model presented in this paper has been adopted on Covstat.it. Errata corrige in the abstract

Published
2020

25. Weekly chemotherapy as first line treatment in frail head and neck cancer patients in the immunotherapy era

Author

Botticelli, Andrea, Pomati, Giulia, Cirillo, Alessio, Mammone, Giulia, Ciurluini, Fabio, Cerbelli, Bruna, Sciattella, Paolo, Ralli, Massimo, Romeo, Umberto, De Felice, Francesca, Catalano, Carlo, Vullo, Francesco, Della Monaca, Marco, Amirhassankhani, Sasan, Tomao, Silverio, Valentini, Valentino, De Vincentiis, Marco, Tombolini, Vincenzo, Della Rocca, Carlo, Polimeni, Antonella, di Gioia, Cira, Corsi, Alessandro, D’Amati, Giulia, Mezi, Silvia, and Marchetti, Paolo

Published
2021
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27. Diagnostic and therapeutic results of aqueous real-time polymerase chain reaction in infectious uveitis.

Author

Tombolini, Beatrice, Menean, Matteo, Cicinelli, Maria Vittoria, Marchese, Alessandro, Cavalleri, Michele, Brambati, Maria, Modorati, Giulio Maria, Bandello, Francesco, and Miserocchi, Elisabetta

Abstract

Copyright of Canadian Journal of Ophthalmology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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29. Accelerator Tests of Crystal Undulators

Author

Biryukov, V. M., Afonin, A. G., Baranov, V. T., Baricordi, S., Bellucci, S., Britvich, G. I., Chepegin, V. N., Chesnokov, Yu. A., Balasubramanian, C., Giannini, G., Guidi, V., Ivanov, Yu. M., Kotov, V. I., Kushnirenko, A., Maisheev, V. A., Malagu, C., Martinelli, G., Milan, E., Petrunin, A. A., Pikalov, V. A., Skorobogatov, V. V., Stefancich, M., Terekhov, V. I., Tombolini, F., and Uggerhoj, U. I.

Subjects
Physics - Accelerator Physics
Abstract

A series of Silicon crystal undulator samples were produced based on the approach presented in PRL 90 (2003) 034801, with the periods of undulation from 0.1 mm to 1 mm, and the number of periods on the order of 10. The samples were characterized by X-rays, revealing the sine-like shape of the crystal lattice in the bulk. Next step in the characterization has been the channeling tests done with 70 GeV protons, where good channeling properties of the undulated Silicon lattice have been observed. The photon radiation tests of crystal undulators with high energy positrons are in progress on several locations: IHEP Protvino, LNF Frascati, and CERN SPS. The progress in the experimental activities and the predictions from detailed simulations are reported., Comment: Invited talk at the NATO ARW "Advanced Photon Sources and Their Application" (Nor Hamberd, Armenia August 29 – September 02, 2004)

Published
2004

31. Crystal Undulator As A Novel Compact Source Of Radiation

Author

Bellucci, S., Bini, S., Giannini, G., Biryukov, V. M., Britvich, G. I., Chesnokov, Yu. A., Kotov, V. I., Maisheev, V. A., Pikalov, V. A., Guidi, V., Malagu, C., Martinelli, G., Stefancich, M., Vincenzi, D., Ivanov, Yu. M., Petrunin, A. A., Skorobogatov, V. V., and Tombolini, F.

Subjects
Physics - Accelerator Physics, Physics - Instrumentation and Detectors
Abstract

A crystalline undulator (CU) with periodically deformed crystallographic planes is capable of deflecting charged particles with the same strength as an equivalent magnetic field of 1000 T and could provide quite a short period L in the sub-millimeter range. We present an idea for creation of a CU and report its first realization. One face of a silicon crystal was given periodic micro-scratches (grooves), with a period of 1 mm, by means of a diamond blade. The X-ray tests of the crystal deformation have shown that a sinusoidal-like shape of crystalline planes goes through the bulk of the crystal. This opens up the possibility for experiments with high-energy particles channeled in CU, a novel compact source of radiation. The first experiment on photon emission in CU has been started at LNF with 800 MeV positrons aiming to produce 50 keV undulator photons., Comment: Presented at PAC 2003 (Portland, May 12-16)

Published
2003
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35. NRF2 orchestrates the redox regulation induced by radiation therapy, sustaining embryonal and alveolar rhabdomyosarcoma cells radioresistance

Author

Marampon, Francesco, Codenotti, Silvia, Megiorni, Francesca, Del Fattore, Andrea, Camero, Simona, Gravina, Giovanni Luca, Festuccia, Claudio, Musio, Daniela, De Felice, Francesca, Nardone, Valerio, Santoro, Anna Natalizia, Dominici, Carlo, Fanzani, Alessandro, Pirtoli, Luigi, Fioravanti, Antonella, Tombolini, Vincenzo, Cheleschi, Sara, and Tini, Paolo

Published
2019
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37. PHENOTYPIC CHARACTERIZATION OF PREDICTORS FOR DEVELOPMENT AND PROGRESSION OF GEOGRAPHIC ATROPHY USING OPTICAL COHERENCE TOMOGRAPHY

Author

Fragiotta, Serena, Dysli, Chantal, Parravano, Mariacristina, Sacconi, Riccardo, Fantaguzzi, Federico, Servillo, Andrea, Severo, Alice Antonella, Tombolini, Beatrice, Costanzo, Eliana, De Geronimo, Daniele, Capuano, Vittorio, Souied, Eric, Bandello, Francesco, and Querques, Giuseppe

Abstract

Supplemental Digital Content is Available in the Text.The identification of nonneovascular retinal pigment epithelium-basal lamina–Bruch membrane splitting represented the main optical coherence tomography phenotype involved in the progression of retinal atrophy. This phenotype is associated with a faster evolution with a more significant expansion of the atrophic area compared with other phenotypic lesions.

Published
2024
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38. Clinically relevant radioresistant rhabdomyosarcoma cell lines: functional, molecular and immune-related characterization

Author

Petragnano, Francesco, Pietrantoni, Ilaria, Camero, Simona, Codenotti, Silvia, Milazzo, Luisa, Vulcano, Francesca, Macioce, Giampiero, Giordani, Ilenia, Tini, Paolo, Cheleschi, Sara, Gravina, Giovanni Luca, Festuccia, Claudio, Rossetti, Alessandra, Delle Monache, Simona, Ordinelli, Alessandra, Ciccarelli, Carmela, Mauro, Annunziata, Barbara, Barboni, Antinozzi, Cristina, Schiavetti, Amalia, Maggio, Roberto, Di Luigi, Luigi, Polimeni, Antonella, Marchese, Cinzia, Tombolini, Vincenzo, Fanzani, Alessandro, Bernabò, Nicola, Megiorni, Francesca, and Marampon, Francesco

Published
2020
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41. Histone deacetylase inhibitor ITF2357 (givinostat) reverts transformed phenotype and counteracts stemness in in vitro and in vivo models of human glioblastoma

Author

Marampon, Francesco, Leoni, Flavio, Mancini, Andrea, Pietrantoni, Ilaria, Codenotti, Silvia, Letizia, Ferella, Megiorni, Francesca, Porro, Giuliana, Galbiati, Elisabetta, Pozzi, Pietro, Mascagni, Paolo, Budillon, Alfredo, Maggio, Roberto, Tombolini, Vincenzo, Fanzani, Alessandro, Gravina, Giovanni Luca, and Festuccia, Claudio

Published
2019
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42. Testosterone-mediated activation of androgenic signalling sustains in vitro the transformed and radioresistant phenotype of rhabdomyosarcoma cell lines

Author

Giannattasio, S., Megiorni, F., Di Nisio, V., Del Fattore, A., Fontanella, R., Camero, S., Antinozzi, C., Festuccia, C., Gravina, G. L., Cecconi, S., Dominici, C., Di Luigi, L., Ciccarelli, C., De Cesaris, P., Riccioli, A., Zani, B. M., Lenzi, A., Pestell, R. G., Filippini, A., Crescioli, C., Tombolini, V., and Marampon, F.

Published
2019
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43. PARP inhibitors affect growth, survival and radiation susceptibility of human alveolar and embryonal rhabdomyosarcoma cell lines

Author

Camero, Simona, Ceccarelli, Simona, De Felice, Francesca, Marampon, Francesco, Mannarino, Olga, Camicia, Lucrezia, Vescarelli, Enrica, Pontecorvi, Paola, Pizer, Barry, Shukla, Rajeev, Schiavetti, Amalia, Mollace, Maria Giovanna, Pizzuti, Antonio, Tombolini, Vincenzo, Marchese, Cinzia, Megiorni, Francesca, and Dominici, Carlo

Published
2019
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44. Unusual presentation of ocular surface squamous neoplasia in a young healthy patient: A case report

Author

Knutsson, Karl Anders, Tombolini, Beatrice, Paganoni, Giorgio, Rama, Paolo, and Bandello, Francesco

Abstract

Purpose To report an unusual case of ocular surface squamous neoplasia (OSSN) associated with human papilloma virus (HPV)-16 infection with an atypical morphology in a young otherwise healthy patient.Case description A 17 year-old healthy male was referred to our department for evaluation of a corneal infiltrate with anterior stromal neovascularization in the right eye. One year before, the patient underwent an excision of a corneo-conjunctival lesion that was located inferiorly in the same eye. Histopathological analysis had shown moderate and severe dysplasia of the conjunctival epithelium and resulted positive for HPV-16. We performed a diagnostic incisional biopsy of the limbal conjunctiva and of the corneal epithelium for histological examination and molecular testing for HPV and Chlamydia by using polymerase chain reaction (PCR). Histopathologic evaluation demonstrated low-grade dysplasia of conjunctiva. PCR testing of the corneal epithelium was positive for HPV-16, similarly to the first biopsy performed by another centre. The patient was successfully treated with topical interferon alfa-2b (1,000,000 IU/ml) for a total of six months. After the treatment, the corneal infiltrate improved dramatically with regression of neovascularization and improvement of corneal transparency and vision.Discussion The present report described an atypical presentation of HPV-related OSSN due to its unusual morphology, young age of onset and absence of associated comorbidity.Conclusion Conservative treatment with topical interferon-alpha 2b could be used to treat successfully HPV-16 positive OSSN, with no corneal irregularity or potential loss of vision compared to surgical excision.

Published
2024
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49. A Brazilian case of exudative perifoveal vascular anomalous complex responsive to aflibercept intravitreal injections

Author

Cunha de Souza, Eduardo, Tombolini, Beatrice, Sacconi, Riccardo, Bandello, Francesco, and Querques, Giuseppe

Abstract

Purpose To report a case of exudative perifoveal exudative vascular anomalous complex (ePVAC) in a Brazilian healthy patient that underwent a complete resolution after aflibercept intravitreal injections.Case description A 41-year-old healthy Brazilian man complained of acute central vision loss in his right eye (RE). Fundus examination showed a perifoveal hemorrhagic aneurysmal lesion, accompanied by several hard exudates in RE. On fluorescein angiography, these abnormalities showed a progressive hyperfluorescence with surrounding leakage. Optical coherence tomography (OCT) revealed a deep, perifoveal hyporeflective cystic space with a hyperreflective wall and hyperreflective material inside of fibrin-like aspect. Around this aneurism, intraretinal hyporeflective spaces suggestive of exudation were detected. Nor pathological flow signal, or telangiectatic dilations were evidenced on OCT-angiography. Therefore, a diagnosis of exudative ePVAC in RE was hypothesized. After an initial observation, the patient underwent three monthly aflibercept intravitreal injections (0.05 ml/2 mg), with a significative anatomical and functional improvement after two weeks from first dose. On last follow-up at five months from baseline, patient experienced no evidence of new exudation and a stable visual acuity.Discussion Placental growth factor (PlGF) may impact on pericytes’ dropout, and thus on ePVAC development. In contrast to the other anti-VEGF drugs, aflibercept is the only molecule contrasting PlGF. Therefore, aflibercept would act on ePVAC not as an anti-VEGF drug, but rather as an anti-PlGF one.Conclusion This report encouraged the use of aflibercept as a therapeutic option for ePVAC. Further studies are required to confirm our result and the impact of PlGF on ePVAC pathogenesis.

Published
2024
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