Search

Your search keyword '"Tomczyk, Jadwiga"' showing total 8 results
Start Over Author "Tomczyk, Jadwiga"
8 results on '"Tomczyk, Jadwiga"'

2. Brain activity monitoring by compressed spectral array during deep hypothermic circulatory arrest in acute aortic dissection surgery

Author

Urbanowicz, Tomasz K., Budniak, Wiktor, Buczkowski, Piotr, Perek, Bartłomiej, Walczak, Maciej, Tomczyk, Jadwiga, Katarzyński, Sławomir, and Jemielity, Marek

Subjects
dissection, DHCA, CSA, Experimental Cardiovascular and Lung Research, brain bioactivity
Abstract

Monitoring the central nervous system during aortic dissection repair may improve the understanding of the intraoperative changes related to its bioactivity.The aim of the study was to evaluate the influence of deep hypothermia on intraoperative brain bioactivity measured by the compressed spectral array (CSA) method and to assess the influence of the operations on postoperative cognitive function.The study enrolled 40 patients (31 men and 9 women) at the mean age of 60.2 ± 8.6 years, diagnosed with acute aortic dissection. They underwent emergency operations in deep hypothermic circulatory arrest (DHCA). During the operations, brain bioactivity was monitored with the compressed spectral array method.There were no intraoperative deaths. Electrocerebral silence during DHCA was observed in 31 patients (74%). The lowest activity was observed during DHCA: it was 0.01 ± 0.05 nW in the left hemisphere and 0.01 ± 0.03 nW in the right hemisphere. The postoperative results of neurological tests deteriorated statistically significantly (26.9 ± 1.7 points vs. 22.0 ± 1.7 points; p0.001), especially among patients who exhibited brain activity during DHCA.The compressed spectral array method is clinically useful in monitoring brain bioactivity during emergency operations of acute aortic dissections. Electrocerebral silence occurs in 75% of patients during DHCA. The cognitive function of patients deteriorates significantly after operations with DHCA.Monitorowanie czynności mózgu podczas operacji rozwarstwień aorty może przyczynić się do lepszego zrozumienia śródoperacyjnych zmian jego czynności bioelektrycznej.Ocena śródoperacyjna czynności bioelektrycznej mózgu za pomocą badania skompresowanego rozkładu widma (Badaniem objęto 40 chorych (31 mężczyzn i 9 kobiet) w średnim wieku 60,2 ± 8,6 roku, z rozpoznaniem ostrego rozwarstwienia aorty, poddanych leczeniu chirurgicznemu w trybie nagłym, z zastosowaniem DHCA. Śródoperacyjnie czynność bioelektryczną mózgu monitorowano za pomocą badania CSA.W okresie śródoperacyjnym nie zmarł żaden pacjent. U 31 chorych (74%) podczas DHCA obserwowano ciszę bioelektryczną mózgu. Najniższą moc całkowitą aktywności bioelektrycznej mózgu stwierdzono podczas DHCA, odpowiednio, dla półkuli lewej 0,01 ± 0,05 nW oraz dla półkuli prawej 0,01 ± 0,03 nW. Wyniki testów neurologicznych uległy istotnie statystycznie pogorszeniu przede wszystkim u chorych, u których w okresie DHCA obserwowano aktywność bioelektryczną mózgu.Podczas operacji w głębokiej hipotermii do całkowitego zaniknięcia czynności bioelektrycznej mózgu dochodzi u ok. 75% chorych. Funkcje poznawcze u chorych operowanych w głębokiej hipotermii ulegają istotnemu pogorszeniu we wczesnym okresie pooperacyjnym szczególnie u chorych, u których podczas DHCA obserwowano aktywność bioelektryczną mózgu.

Published
2014

7. Effect of milrinone therapy on splanchnic perfusion after heart transplantation.

Author

Urbanowicz T, Ligowski M, Camacho E, Walczak M, Straburzyńska-Migaj E, Tomczyk J, and Jemielity M

Subjects
Adult, Alanine Transaminase blood, Amylases blood, Aspartate Aminotransferases blood, Cardiotonic Agents administration & dosage, Cardiotonic Agents therapeutic use, Female, Glomerular Filtration Rate drug effects, Humans, Lactic Acid blood, Male, Middle Aged, Milrinone administration & dosage, Phosphodiesterase 3 Inhibitors administration & dosage, Splanchnic Circulation physiology, Heart Transplantation, Milrinone therapeutic use, Phosphodiesterase 3 Inhibitors therapeutic use, Splanchnic Circulation drug effects
Abstract

Background: Milrinone is a selective inhibitor of the cAMP-specific phosphodiesterase III isoenzyme in myocardium and vascular smooth muscle. Milrinone administration following heart transplantation is routine practice. The purpose of this study was to evaluate the influence of milrinone therapy on splanchnic perfusion following heart transplantation., Material and Methods: There were 12 patients (10 males and 2 females) with a mean age of 42 ± 12 who underwent heart transplantation. Milrinone parenteral following surgery was started after surgery and continued for the next 67 ± 4 h. Repeated Swann-Ganz measurements and control transthoracic echocardiography were performed. Blood samples were taken to estimate level of lactic acid (LA), liver transaminases, serum amylase, and GFR ratio., Results: The mean time of milrinone administration was 67 ± 4 h. The serum LA increase following milrinone discontinuation was 1.7 ± 0.7 mmol/dm(3) vs. 3.8 ± 0.9 mmol/dm(3), (p<0.0001). The serum AST increase following milrinone discontinuation was 79 ± 30 IU/L vs. 135 ± 55 IU/L, p<0.04). We found a significant increase of blood ALT (29 ± 9 IU/L vs. 60 ± 23 IU/L) (p<0.0002) after milrinone withdrawn. There was a progressive increase in serum amylase levels after milrinone was withdrawn (80.6 ± 29 IU/L vs. 134 ± 45 IU/L, p<0.05)., Conclusions: Milrinone withdrawal during the postoperative period was associated with deterioration of splanchnic perfusion, as shown by a transient increase in lactic acid and serum increase of aminotransferases (ALT/ASP) concentration and amylase activity. The study results show the extracardiac effects of milrinone therapy.

Published
2014
Full Text
View/download PDF

8. [Surgery for massive pulmonary embolism following coronary angioplasty--a case report].

Author

Breborowicz P, Grygier M, Jankowski J, Dyszkiewicz W, Sarnowski W, Tomczyk J, Walczak M, Mularek-Kubzdela T, Perek B, Breborowicz E, Kasinowski R, Dziarmaga M, and Cieśliński A

Subjects
Coronary Angiography, Electrocardiography, Female, Humans, Middle Aged, Pulmonary Embolism diagnostic imaging, Pulmonary Embolism physiopathology, Tomography, Spiral Computed, Angioplasty, Balloon, Coronary adverse effects, Coronary Artery Disease complications, Pulmonary Embolism etiology, Pulmonary Embolism surgery
Abstract

A case of a 49-year-old female with acute coronary syndrome is presented. The patient underwent coronary angioplasty with stent implantation. Due to the recurrence of pain and dyspnea a repeated coronary angiography was performed 3 hours later which confirmed good result of angioplasty. For the next 48 hours a local compression on both femoral arteries was maintained and the patient received full anticoagulant and antiplatelet treatment. However, clinical condition of the patient continued to deteriorate. Echocardiography and spiral computerised tomography revealed the presence of a massive pulmonary embolism. The patient underwent surgery and fully recovered.

Published
2004

Catalog

Books, media, physical & digital resources
See catalog results