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2. Criterion validity of ultrasound in the identification of calcium pyrophosphate crystal deposits at the knee:an OMERACT ultrasound study

Author

Filippou, Georgios, Scanu, Anna, Adinolfi, Antonella, Toscano, Carmela, Gambera, Dario, Largo, Raquel, Naredo, Esperanza, Calvo, Emilio, Herrero-Beaumont, Gabriel, Zufferey, Pascal, Bonjour, Christel Madelaine, Maccarter, Daryl K., Makman, Stanley, Weber, Zachary, Figus, Fabiana, Möller, Ingrid, Gutierrez, Marwin, Pineda, Carlos, Clavijo Cornejo, Denise, Garcia, Hector, Ilizaliturri, Victor, Mendoza Torres, Jaime, Pichardo, Raul, Rodriguez Delgado, Luis Carlos, Filippucci, Emilio, Cipolletta, Edoardo, Serban, Teodora, Cirstoiu, Catalin, Vreju, Florentin Ananu, Grecu, Dan, Mouterde, Gaël, Govoni, Marcello, Punzi, Leonardo, Damjanov, Nemanja S., Keen, Helen Isobel, Bruyn, George A.W., Terslev, Lene, D'agostino, Maria Antonietta, Scirè, Carlo Alberto, Iagnocco, Annamaria, Filippou, Georgios, Scanu, Anna, Adinolfi, Antonella, Toscano, Carmela, Gambera, Dario, Largo, Raquel, Naredo, Esperanza, Calvo, Emilio, Herrero-Beaumont, Gabriel, Zufferey, Pascal, Bonjour, Christel Madelaine, Maccarter, Daryl K., Makman, Stanley, Weber, Zachary, Figus, Fabiana, Möller, Ingrid, Gutierrez, Marwin, Pineda, Carlos, Clavijo Cornejo, Denise, Garcia, Hector, Ilizaliturri, Victor, Mendoza Torres, Jaime, Pichardo, Raul, Rodriguez Delgado, Luis Carlos, Filippucci, Emilio, Cipolletta, Edoardo, Serban, Teodora, Cirstoiu, Catalin, Vreju, Florentin Ananu, Grecu, Dan, Mouterde, Gaël, Govoni, Marcello, Punzi, Leonardo, Damjanov, Nemanja S., Keen, Helen Isobel, Bruyn, George A.W., Terslev, Lene, D'agostino, Maria Antonietta, Scirè, Carlo Alberto, and Iagnocco, Annamaria

Abstract

Objective To evaluate the discriminatory ability of ultrasound in calcium pyrophosphate deposition disease (CPPD), using microscopic analysis of menisci and knee hyaline cartilage (HC) as reference standard. Methods Consecutive patients scheduled for knee replacement surgery, due to osteoarthritis (OA), were enrolled. Each patient underwent ultrasound examination of the menisci and HC of the knee, scoring each site for presence/absence of CPPD. Ultrasound signs of inflammation (effusion, synovial proliferation and power Doppler) were assessed semiquantitatively (0-3). The menisci and condyles, retrieved during surgery, were examined microscopically by optical light microscopy and by compensated polarised microscopy. CPPs were scored as present/absent in six different samples from the surface and from the internal part of menisci and cartilage. Ultrasound and microscopic analysis were performed by different operators, blinded to each other's findings. Results 11 researchers from seven countries participated in the study. Of 101 enrolled patients, 68 were included in the analysis. In 38 patients, the surgical specimens were insufficient. The overall diagnostic accuracy of ultrasound for CPPD was of 75% -sensitivity of 91% (range 71%-87% in single sites) and specificity of 59% (range 68%-92%). The best sensitivity and specificity were obtained by assessing in combination by ultrasound the medial meniscus and the medial condyle HC (88% and 76%, respectively). No differences were found between patients with and without CPPD regarding ultrasound signs of inflammation. Conclusion Ultrasound demonstrated to be an accurate tool for discriminating CPPD. No differences were found between patents with OA alone and CPPD plus OA regarding inflammation.

Published
2021

3. The two faces of the same medal… or maybe not? Comparing osteoarthritis and calcium pyrophosphate deposition disease: a laboratory and ultrasonographic study

Author

Filippou, Georgios, primary, Scanu, Anna, additional, Adinolfi, Antonella, additional, Picerno, Valentina, additional, Toscano, Carmela, additional, Bortoluzzi, Alessandra, additional, Frediani, Bruno, additional, Govoni, Marcello, additional, Punzi, Leonardo, additional, and Scirè, Carlo Alberto, additional

Published
2021
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4. Criterion validity of ultrasound in the identification of calcium pyrophosphate crystal deposits at the knee: an OMERACT ultrasound study

Author

Filippou, Georgios, primary, Scanu, Anna, additional, Adinolfi, Antonella, additional, Toscano, Carmela, additional, Gambera, Dario, additional, Largo, Raquel, additional, Naredo, Esperanza, additional, Calvo, Emilio, additional, Herrero-Beaumont, Gabriel, additional, Zufferey, Pascal, additional, Bonjour, Christel Madelaine, additional, MacCarter, Daryl K, additional, Makman, Stanley, additional, Weber, Zachary, additional, Figus, Fabiana, additional, Möller, Ingrid, additional, Gutierrez, Marwin, additional, Pineda, Carlos, additional, Clavijo Cornejo, Denise, additional, Garcia, Hector, additional, Ilizaliturri, Victor, additional, Mendoza Torres, Jaime, additional, Pichardo, Raul, additional, Rodriguez Delgado, Luis Carlos, additional, Filippucci, Emilio, additional, Cipolletta, Edoardo, additional, Serban, Teodora, additional, Cirstoiu, Catalin, additional, Vreju, Florentin Ananu, additional, Grecu, Dan, additional, Mouterde, Gaël, additional, Govoni, Marcello, additional, Punzi, Leonardo, additional, Damjanov, Nemanja S, additional, Keen, Helen Isobel, additional, Bruyn, George AW, additional, Terslev, Lene, additional, D'Agostino, Maria-Antonietta, additional, Scirè, Carlo Alberto, additional, and Iagnocco, Annamaria, additional

Published
2020
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6. OP0319 DIAGNOSTIC ACCURACY OF ULTRASOUND IN CALCIUM PYROPHOSPHATE DEPOSITION DISEASE: PRELIMINARY RESULTS OF THE OMERACT US IN CPPD SUB-GROUP

Author

Filippou, Georgios, primary, Scanu, Anna, additional, Adinolfi, Antonella, additional, Toscano, Carmela, additional, Largo-Carazo, Raquel, additional, Naredo, Esperanza, additional, Calvo, Emilio, additional, Herrero-Beaumont, Gabriel, additional, Zufferey, Pascal, additional, Madelaine-Bonjour, Christel, additional, Maccarter, Daryl, additional, Makman, Stanley, additional, Weber, Zachary, additional, Möller, Ingrid, additional, Gutierrez, Marwin, additional, Pineda, Carlos, additional, Cornejo, Denise Clavijo, additional, García, Héctor, additional, Ilizaliturri, Victor, additional, Torres, Jaime Mendoza, additional, Pichardo, Raul, additional, Rodriguez Delgado, Luis Carlos, additional, Filippucci, Emilio, additional, Cipolletta, Edoardo, additional, Serban, Teodora, additional, Vreju, Florentin Ananu, additional, Mouterde, Gael, additional, D’agostino, Maria-Antonietta, additional, Govoni, Marcello, additional, Punzi, Leonardo, additional, Damjanov, Nemanja, additional, Terslev, Lene, additional, Azzolin, Irene, additional, Guerrini, Giulio, additional, Scirè, Carlo Alberto, additional, and Iagnocco, Annamaria, additional

Published
2019
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7. Criterion validity of ultrasound in the identification of calcium pyrophosphate crystal deposits at the knee: an OMERACT ultrasound study.

Author

Filippou, Georgios, Scanu, Anna, Adinolfi, Antonella, Toscano, Carmela, Gambera, Dario, Largo, Raquel, Naredo, Esperanza, Calvo, Emilio, Herrero-Beaumont, Gabriel, Zufferey, Pascal, Bonjour, Christel Madelaine, MacCarter, Daryl K., Makman, Stanley, Weber, Zachary, Figus, Fabiana, Möller, Ingrid, Gutierrez, Marwin, Pineda, Carlos, Cornejo, Denise Clavijo, and Garcia, Hector

Abstract

Objective: To evaluate the discriminatory ability of ultrasound in calcium pyrophosphate deposition disease (CPPD), using microscopic analysis of menisci and knee hyaline cartilage (HC) as reference standard.Methods: Consecutive patients scheduled for knee replacement surgery, due to osteoarthritis (OA), were enrolled. Each patient underwent ultrasound examination of the menisci and HC of the knee, scoring each site for presence/absence of CPPD. Ultrasound signs of inflammation (effusion, synovial proliferation and power Doppler) were assessed semiquantitatively (0-3). The menisci and condyles, retrieved during surgery, were examined microscopically by optical light microscopy and by compensated polarised microscopy. CPPs were scored as present/absent in six different samples from the surface and from the internal part of menisci and cartilage. Ultrasound and microscopic analysis were performed by different operators, blinded to each other's findings.Results: 11 researchers from seven countries participated in the study. Of 101 enrolled patients, 68 were included in the analysis. In 38 patients, the surgical specimens were insufficient. The overall diagnostic accuracy of ultrasound for CPPD was of 75%-sensitivity of 91% (range 71%-87% in single sites) and specificity of 59% (range 68%-92%). The best sensitivity and specificity were obtained by assessing in combination by ultrasound the medial meniscus and the medial condyle HC (88% and 76%, respectively). No differences were found between patients with and without CPPD regarding ultrasound signs of inflammation.Conclusion: Ultrasound demonstrated to be an accurate tool for discriminating CPPD. No differences were found between patents with OA alone and CPPD plus OA regarding inflammation. [ABSTRACT FROM AUTHOR]

Published
2021
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8. Identification of calcium pyrophosphate deposition disease (CPPD) by ultrasound: reliability of the OMERACT definitions in an extended set of joints—an international multiobserver study by the OMERACT Calcium Pyrophosphate Deposition Disease Ultrasound Subtask Force

Author

Filippou, Georgios, primary, Scirè, Carlo Alberto, additional, Adinolfi, Antonella, additional, Damjanov, Nemanja S, additional, Carrara, Greta, additional, Bruyn, George A W, additional, Cazenave, Tomas, additional, D’Agostino, Maria Antonietta, additional, Delle Sedie, Andrea, additional, Di Sabatino, Valentina, additional, Diaz Cortes, Mario Enrique, additional, Filippucci, Emilio, additional, Gandjbakhch, Frederique, additional, Gutierrez, Marwin, additional, Maccarter, Daryl K, additional, Micu, Mihaela, additional, Möller Parera, Ingrid, additional, Mouterde, Gaël, additional, Mortada, Mohamed Atia, additional, Naredo, Esperanza, additional, Pineda, Carlos, additional, Porta, Francesco, additional, Reginato, Anthony M, additional, Satulu, Iulia, additional, Schmidt, Wolfgang A, additional, Serban, Teodora, additional, Terslev, Lene, additional, Vlad, Violeta, additional, Vreju, Florentin Ananu, additional, Zufferey, Pascal, additional, Bozios, Panagiotis, additional, Toscano, Carmela, additional, Picerno, Valentina, additional, and Iagnocco, Annamaria, additional

Published
2018
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9. Definition and Reliability Assessment of Elementary Ultrasonographic Findings in Calcium Pyrophosphate Deposition Disease: A Study by the OMERACT Calcium Pyrophosphate Deposition Disease Ultrasound Subtask Force

Author

Filippou, Georgios, primary, Scirè, Carlo A., additional, Damjanov, Nemanja, additional, Adinolfi, Antonella, additional, Carrara, Greta, additional, Picerno, Valentina, additional, Toscano, Carmela, additional, Bruyn, George A., additional, D’Agostino, Maria Antonietta, additional, Delle Sedie, Andrea, additional, Filippucci, Emilio, additional, Gutierrez, Marwin, additional, Micu, Mihaela, additional, Möller, Ingrid, additional, Naredo, Esperanza, additional, Pineda, Carlos, additional, Porta, Francesco, additional, Schmidt, Wolfgang A., additional, Terslev, Lene, additional, Vlad, Violeta, additional, Zufferey, Pascal, additional, and Iagnocco, Annamaria, additional

Published
2017
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10. One year in review 2016: idiopathic inflammatory myopathies.

Author

Orlandi M, Barsotti S, Cioffi E, Tenti S, Toscano C, Baldini C, and Neri R

Subjects
Humans, Immunosuppressive Agents therapeutic use, Myositis diagnosis, Myositis drug therapy
Abstract

Idiopathic inflammatory myopathies (IIM) are a group of rare, acquired, clinically heterogeneous autoimmune inflammatory muscle disorders characterised by muscle weakness and multisystem involvement. Recently, new concepts about pathogenesis, diagnosis and treatment of these complex diseases have been provided. The purpose of this manuscript is to summarise the most relevant literature contributions published over the last year.

Published
2016

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