Search

Between 2 and 8.5% of patients who recover from COVID-19 do not develop antibodies, and the durability of IgG antibodies is under scrutiny. Therefore, the presence and persistence of IgM and IgG antibodies were evaluated in a group of patients diagnosed with SARS-CoV-2 from May to August 2020. Out of 2199 suspected COVID-19 cases, 1264 were confirmed for SARS-CoV-2 by rRT-PCR; 328 consented to participate in the study, with 220 participants followed for 9 months, including 124 men (56%) and 96 women (44%). The primary symptoms were headache, dry cough, and fever. IgG antibodies developed in 95% of patients within 4 weeks post-diagnosis, and a second evaluation at 9 months showed that 72.7% still had detectable IgG antibodies. The presence of IgM in one individual (0.45%) suggested the possibility of reinfection. [ABSTRACT FROM AUTHOR]

Objetive: ensure trat there is no change in the work area and angle of attack when camparing the orbitozygomatic approach with respect to the variant proposed approach. Material and methods: we performed in 15 human skulls preserved with the technique of the Faculty of Medicine (UNAM) orbitozygomatic approach and the proposed variant (internal orbitcranial transzygomatic), measurements were made of angle of attack and work area, we performed the statistical analysis of the results. Results: the work area remains unchanged in both approaches(orbitozygomatic and variant), the angle of attack is greater in the orbitozygomatic approach with respect to the variant. Conclusions: the approach proposed variant (internal orbitocranial transzygomatic) does not change the work area but has a lower angle of attack with respect to the clasical orbitozygomatic approach. [ABSTRACT FROM AUTHOR]

Diabetes mellitus constitutes one of the main national and global health problems, besides being a strong ingredient that increases the risk of cardiovascular disease, the main national cause of mortality. Included among the therapeutic options for this disease is allogeneic pancreatic islet transplantation, an alternative modality used in a specific group of patients with type 1 diabetes mellitus. Islet transplantation has produced an improvement in the quality of life, a decrease in hypoglycemia-unawareness related events, a decrease in daily insulin dose, and occasionally, the independence from the use of insulin. In this review we intend to inform of the recent trends in research on this subject, that have as objective to achieve longer survival of the graft and/or avoiding the use of post-transplant immunosuppression. [ABSTRACT FROM AUTHOR]

The discovery of novel gene regulatory systems under the control of small RNAs has had a significant impact on molecular biology. MicroRNAs (miRNAs) are a class of small non-coding RNAs (those that do not encode protein) that regulate gene expression post-transcriptionally. They bind with imperfect complementary to their target messenger RNAs (mRNAs), generally within the 3′-untranslated region, and repress protein production by destabilizing the mRNA and translational silencing. Large numbers' of miRNAs have been identified in the genomes of various species including human; yet the number of the miRNA is still rising due to the combined efforts of molecular biology and bioinformatic prediction. It has been reported that this molecules regulate cellular functions, therefore not surprising that microRNAs are implicated in a wide variety of diseases (i.e. cancer and diabetes mellitus). The purpose of this review is to provide current information on miRNA synthesis and the progress in the understanding of the mechanisms of miRNA-mediated gene silencing, as well as the potential use of miRNAs for diagnosis and therapy of diseases. [ABSTRACT FROM AUTHOR]

Unlabelled: Information about HCV genotypes in infected patients from different regions of Mexico is limited., Objective: To determine the prevalence of HCV genotypes in a group of HCV infected patients who attended a third level Hospital in Northeast of Mexico., Methods: Genotyping analysis was performed using the InnoLiPA-HCV genotype assay in 147 patients (65 males and 82 females, mean age 44 +/- 12 years) with positive anti-HCV antibodies and detectable HCV-RNA levels., Results: Infected individuals were more likely to be female (56%). Histological data showed that 63% of the patients had chronic hepatitis, while the remainder presented cirrhosis (37%). The most frequent HCV genotype was 1 (73%). We found the following distribution: genotype 1 (2.7%), 1a (28.6%), 1b (37.4%), 1a/1b (4.1%), 2a (1.4%), 2b (8.8%), 2c (0.7%), 2a/2c (2.7%), 3 (2%), 3a (10.2%), 4 (0.7%) and 4c (0.7%). The most frequent associated risk factor was blood transfusion (72.5%)., Conclusion: Prevalence of HCV genotypes in the Northeast of Mexico is similar to those reported previously in other Mexican regions and the most frequent risk factor continues being blood transfusion.

Infection with hepatitis C virus (HCV) is a global public health issue. More than 200 million people in the world are infected with HCV. Hepatitis C is considered one of the main causes of chronic hepatitis, cirrhosis, hepatocellular carcinoma and liver transplantation. The identification of the viral genome quickly allowed delineation of genomic organization, and the structure and biochemical characterization of the proteins of HCV. However, it has been difficult to study its life cycle, as well as the development of antiviral agents due to the lack of a system of permissible culture. Numerous attempts have been reported to establish an in vitro system for the study of HCV. Recently, a system of efficient culture was established that allows replication of subgenomic molecules of HCV in a cell line of human hepatoma. In this revision, after a brief description of the molecular biology, means of transmission and clinical characteristics of hepatitis C, some of the experimental models are described that have been developed to date, focusing mainly on the subgenomic replicon system and their use in the development of new antiviral treatments.