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Objective: This study describes the development and characterization of a novel in vitro wound‐healing model based on a full‐thickness reconstructed skin by exposing the tissue to fractional ablative laser treatment. Method: A 3D full‐thickness skin model was fabricated and treated with fractional ablative CO2 laser. Wound‐healing process was characterized by HE staining, noninvasive OCT imaging, immunostaining, as well as transepidermal water loss measurement. Cytokines and proteins involved in the inflammatory and dermal remodeling process were studied by ELISA and protein array assays. Results: Fractional ablative CO2 treatment induced a wound zone of 9 mm in diameter, containing 56 micro‐wounds with 200 μm diameter and 500–700 μm in depth on reconstructed full‐thickness skin model. HE staining revealed a typical wound morphology and healing process with migration of keratinocytes, formation and extrusion of necrotic tissue, and cell inclusion in dermis, which correlates with clinical observations. Based on OCT and TEWL measurements, the re‐epithelialization took place over 2 days. Laser‐triggered keratinocytes proliferation and differentiation were demonstrated by activated Ki67 and Filaggrin expression respectively. Injury‐invoked cytokine ICAM‐1 showed instant upregulation on Day 1. Decreased epidermis thickness and depression of IGFBP‐2 protein level synergistically indicated the unavoidable thermal side effects from laser treatment. Downregulated DKK‐1 protein level and upregulation of α‐SMA together implicated the risk of potential fibrosis post‐laser treatment. Conclusion: This in vitro laser wounded reconstructed skin model captured the key events of wound‐healing process, could be used to investigate the mechanisms of wound‐healing triggered by a commonly used beauty procedure, and also provides a valuable tool for evaluating the efficacy of novel actives for the post‐procedure application. [ABSTRACT FROM AUTHOR]

The knowledge integration perspective on team innovation holds that information elaboration – the exchange, discussion, and integration of task‐relevant information and perspectives – is the core team process driving team innovation. Factors reflecting the informational resources the team can draw on through information elaboration therefore are important influences on team innovation. In this respect, team innovation research points to team functional diversity and to team boundary spanning scouting to acquire information from outside the team. Team innovation research also makes clear that informational resources (as reflected in functional diversity and boundary spanning scouting) do not guarantee team information elaboration, and that identifying moderation in this relationship is particularly valuable. Building on this state of the science, we focus on the moderating role of the team diversity mindset – members' shared understanding of the importance of information elaboration for team performance – in the relationships of team functional diversity and boundary spanning scouting with information elaboration and team innovation. A multi‐wave and multi‐source survey of N = 215 teams involved in knowledge work in various Chinese organizations supported our research model for team boundary spanning scouting but not for team functional diversity. [ABSTRACT FROM AUTHOR]