Search

Your search keyword '"Tullis, D. Elizabeth"' showing total 33 results
Start Over Author "Tullis, D. Elizabeth"
33 results on '"Tullis, D. Elizabeth"'

6. Triaging Access to Critical Care Resources in Patients with Chronic Respiratory Diseases in the Event of a Major COVID-19Surge: Key highlights from the Canadian Thoracic Society (CTS) Position Statement

Author

Gupta, Samir, Batt, Jane, Bourbeau, Jean, Chapman, Kenneth R., Gershon, Andrea, Granton, John, Hambly, Nathan, Hernandez, Paul, Kolb, Martin, Mehta, Sanjay, Mielniczuk, Lisa, Provencher, Steeve, Stephenson, Anne L., Swiston, John, Tullis, D. Elizabeth, Vozoris, Nicholas T., Wald, Joshua, Weatherald, Jason, and Bhutani, Mohit

Subjects
Canada, CFS, clinical frailty score, Critical Care, Cystic Fibrosis, Pulmonary Fibrosis, Respiratory Tract Diseases, PH, pulmonary hypertension, Article, Health Services Accessibility, Pulmonary Disease, Chronic Obstructive, Forced Expiratory Volume, PaO2, partial pressure of oxygen, Pulmonary Medicine, AE, acute exacerbation, IPF, idiopathic pulmonary fibrosis, Humans, COVID-19, 2019 novel coronavirus, Mortality, mMRC, modified Medical Research Council dyspnea scale, PaCO2, partial pressure of carbon dioxide, Societies, Medical, Pulmonary Arterial Hypertension, DLCO, diffusing capacity of the lungs for carbon monoxide, Health Care Rationing, Frailty, CTS, Canadian Thoracic Society, Patient Selection, Oxygen Inhalation Therapy, Surge Capacity, COVID-19, Prognosis, FEV1, forced expiratory volume in the first second, Respiratory Function Tests, REVEAL, Registry to Evaluate Early and Long-Term Pulmonary Arterial Hypertension Disease Management, Intensive Care Units, FVC, forced vital capacity, Chronic Disease, ILD, interstitial lung disease, Health Resources, Pulmonary Diffusing Capacity, Triage, RV, right ventricular
Published
2020

7. Feasibility of Internet-Based Health-Related Quality of Life Data Collection in a Large Patient Cohort

Author

Bhinder, Sacha, Chowdhury, Noori, Granton, John, Krahn, Murray, Tullis, D Elizabeth, Waddell, Thomas K, and Singer, Lianne G

Subjects
Computer applications to medicine. Medical informatics, R858-859.7, Public aspects of medicine, RA1-1270
Abstract

BackgroundPatient registries are commonly used to track survival and medical outcomes in large cohorts. However, large-scale collection of health-related quality of life (HRQOL) data is more challenging because such data must be collected directly from patients. Internet-based HRQOL questionnaires are a potential solution, allowing home data collection with immediate storage in a central database. ObjectivesOur objectives were to investigate the sociodemographic predictors of Internet use and willingness to convey HRQOL information over the Internet in a Canadian tertiary care patient population and to determine whether Internet use patterns of tertiary care patients differ from those of the general Canadian population. Additionally, we sought to identify the success of home completion of Internet-based HRQOL questionnaires, as well as factors hindering home completion. MethodsWe surveyed 644 patients at the Toronto General and St. Michael’s Hospitals from November 2003 through July 2006 within a prospective, longitudinal cohort study of HRQOL in patients with lung disease or lung transplants. Using multiple logistic regression, we assessed patient age, gender, rurality, marital status, and employment or education status as potential sociodemographic predictors of having an Internet-accessible home computer, using email at least weekly, and willingness to complete a quality of life questionnaire over the Internet. Patients electing to complete questionnaires over the Internet were followed from September 2005 through March 2008 to assess completion of HRQOL questionnaires from home, identify barriers for noncompletion, and determine sociodemographic predictors for home completion. ResultsOf the 644 patients, the median age was 51 years, with a similar number of males and females. Most were urban Ontario residents, were unemployed, and were married or in a common-law relationship. Having an Internet-accessible home computer was reported by 79.7% (513/644) of patients and use of email at least weekly by 66.5% (414/623) of patients. A majority of patients (57.1% 368/644) were willing to complete HRQOL questionnaires over the Internet via an emailed link. Of the participating 644 patients, 368 elected to complete future questionnaires from home and, as part of a gradual roll-out of the home HRQOL questionnaire, 211 were sent emails inviting them to do so. Of the invited patients, 78% (165/211) completed at least one questionnaire from home. The most common reason for noncompletion was a lack of or an inability to find time to complete the questionnaire. No statistically significant sociodemographic predictors of Internet use were associated with completion or noncompletion of questionnaires from home. ConclusionsHome, Internet-based HRQOL assessment is feasible in tertiary care patient populations with a high predicted rate of Internet usage based on sociodemographic parameters. A large minority of patients were unwilling or unable to take part in home HRQOL assessments indicating that alternative methods of data collection are still required. However, the majority of patients electing to complete home HRQOL assessments went on to do so over the Internet.

Published
2010
Full Text
View/download PDF

8. Triaging Access to Critical Care Resources in Patients With Chronic Respiratory Diseases in the Event of a Major COVID-19 Surge

Author

Gupta, Samir, primary, Batt, Jane, additional, Bourbeau, Jean, additional, Chapman, Kenneth R., additional, Gershon, Andrea, additional, Granton, John, additional, Hambly, Nathan, additional, Hernandez, Paul, additional, Kolb, Martin, additional, Mehta, Sanjay, additional, Mielniczuk, Lisa, additional, Provencher, Steeve, additional, Stephenson, Anne L., additional, Swiston, John, additional, Tullis, D. Elizabeth, additional, Vozoris, Nicholas T., additional, Wald, Joshua, additional, Weatherald, Jason, additional, and Bhutani, Mohit, additional

Published
2020
Full Text
View/download PDF

9. Position statement from the Canadian Thoracic Society (CTS) on clinical triage thresholds in respiratory disease patients in the event of a major surge during the COVID-19 pandemic

Author

Gupta, Samir, primary, Batt, Jane, additional, Bourbeau, Jean, additional, Chapman, Kenneth R., additional, Gershon, Andrea, additional, Granton, John, additional, Hambly, Nathan, additional, Hernandez, Paul, additional, Kolb, Martin, additional, Mehta, Sanjay, additional, Mielniczuk, Lisa, additional, Provencher, Steeve, additional, Stephenson, Anne L., additional, Swiston, John, additional, Tullis, D. Elizabeth, additional, Vozoris, Nicholas T., additional, Wald, Joshua, additional, Weatherald, Jason, additional, and Bhutani, Mohit, additional

Published
2020
Full Text
View/download PDF

16. A genome-wide association analysis reveals a potential role for recombination in the evolution of antimicrobial resistance in Burkholderia multivorans

Author

Diaz Caballero, Julio, primary, Clark, Shawn T., additional, Wang, Pauline W., additional, Donaldson, Sylva L., additional, Coburn, Bryan, additional, Tullis, D. Elizabeth, additional, Yau, Yvonne C. W., additional, Waters, Valerie J., additional, Hwang, David M., additional, and Guttman, David S., additional

Published
2018
Full Text
View/download PDF

17. A Genome-Wide Association Analysis Reveals a Role for Recombination in the Evolution of Antimicrobial Resistance in Burkholderia multivorans

Author

Diaz Caballero, Julio, primary, Clark, Shawn T., additional, Wang, Pauline W., additional, Donaldson, Sylva L., additional, Coburn, Bryan, additional, Tullis, D. Elizabeth, additional, Yau, Yvonne C.W., additional, Waters, Valerie J., additional, Hwang, David M., additional, and Guttman, David S., additional

Published
2018
Full Text
View/download PDF

20. Global Analysis of the Fungal Microbiome in Cystic Fibrosis Patients Reveals Loss of Function of the Transcriptional Repressor Nrg1 as a Mechanism of Pathogen Adaptation

Author

Kim, Sang Hu, primary, Clark, Shawn T., additional, Surendra, Anuradha, additional, Copeland, Julia K., additional, Wang, Pauline W., additional, Ammar, Ron, additional, Collins, Cathy, additional, Tullis, D. Elizabeth, additional, Nislow, Corey, additional, Hwang, David M., additional, Guttman, David S., additional, and Cowen, Leah E., additional

Published
2015
Full Text
View/download PDF

21. Selective Sweeps and Parallel Pathoadaptation Drive Pseudomonas aeruginosa Evolution in the Cystic Fibrosis Lung

Author

Diaz Caballero, Julio, primary, Clark, Shawn T., additional, Coburn, Bryan, additional, Zhang, Yu, additional, Wang, Pauline W., additional, Donaldson, Sylva L., additional, Tullis, D. Elizabeth, additional, Yau, Yvonne C. W., additional, Waters, Valerie J., additional, Hwang, David M., additional, and Guttman, David S., additional

Published
2015
Full Text
View/download PDF

23. Analysis of the Cystic Fibrosis Lung Microbiota via Serial Illumina Sequencing of Bacterial 16S rRNA Hypervariable Regions

Author

Maughan, Heather, primary, Wang, Pauline W., additional, Diaz Caballero, Julio, additional, Fung, Pauline, additional, Gong, Yunchen, additional, Donaldson, Sylva L., additional, Yuan, Lijie, additional, Keshavjee, Shaf, additional, Zhang, Yu, additional, Yau, Yvonne C. W., additional, Waters, Valerie J., additional, Tullis, D. Elizabeth, additional, Hwang, David M., additional, and Guttman, David S., additional

Published
2012
Full Text
View/download PDF

24. Pulmonary Bacterial Communities in Surgically Resected Noncystic Fibrosis Bronchiectasis Lungs Are Similar to Those in Cystic Fibrosis

Author

Maughan, Heather, primary, Cunningham, Kristopher S., additional, Wang, Pauline W., additional, Zhang, Yu, additional, Cypel, Marcelo, additional, Chaparro, Cecilia, additional, Tullis, D. Elizabeth, additional, Waddell, Thomas K., additional, Keshavjee, Shaf, additional, Liu, Mingyao, additional, Guttman, David S., additional, and Hwang, David M., additional

Published
2012
Full Text
View/download PDF

25. Hepatic Abscess due to Burkholderia (Pseudomonas) cepacia in Cystic Fibrosis

Author

Fraser, Kristin L, Hyland, Robert H, and Tullis, D Elizabeth

Subjects
congenital, hereditary, and neonatal diseases and abnormalities, Article Subject, respiratory tract diseases
Abstract

Burkholderia (Pseudomonas) cepacia has been cultured from bronchial secretions of patients with cystic fibrosis with varying frequency. The overall prevalence in patients over 18 years old at the authors’ centre in Toronto is 51%. Extrapulmonary infections are rare in nonimmunosuppressed patients with cystic fibrosis and B cepacia has been the causative organism in only three previous reports. Two patients with cystic fibrosis are described who developed hepatic abscesses clue to B cepacia. One patient is the sibling of two brothers in whom this complication was previously described.

Published
1995
Full Text
View/download PDF

31. Comparison of Culture and PCR for Detection of Burkholderia cepaciain Sputum Samples of Patients with Cystic Fibrosis

Author

Whitby, Paul W., Dick, Hani L. N., Campbell, Preston W., Tullis, D. Elizabeth, Matlow, Anne, and Stull, Terrence L.

Abstract

ABSTRACTWe investigated the utility of PCR to detect Burkholderia cepaciadirectly in sputum samples at two cystic fibrosis (CF) centers serving children and adults. Following liquefaction of the sputa by using N-acetyl-l-cysteine, DNA was isolated and analyzed by PCRs with three different primer pairs directed toward bacterial rRNA loci. Two primer pairs were putatively specific for B. cepacia. The other pair, which universally amplifies a band from all bacteria, served as a control. Sputum samples were obtained from 219 patients and analyzed independently by culture and by PCR to detect B. cepacia. The analyses were performed blinded with respect to each other. The results of the PCR with sputa demonstrated that the primers directed to the 16S loci demonstrated approximately 95% concordance with culture results and were more specific than those amplifying the 16S to 23S spacer region. In addition, the 16S primer pair putatively identified B. cepaciain seven patients whose sputa were culture negative at this time. Of these culture-negative patients, five had sputum samples that were culture positive for B. cepaciaeither prior or subsequent to this study. The results of this study indicate the utility of PCR as a diagnostic method for the rapid identification of B. cepaciain sputum samples of CF patients. We anticipate that improvements in our taxonomic understanding may allow the design of more specific primers for detection of each species of the B. cepaciacomplex in sputum samples.

Published
1998
Full Text
View/download PDF

32. Selective Sweeps and Parallel Pathoadaptation Drive Pseudomonas aeruginosaEvolution in the Cystic Fibrosis Lung

Author

Diaz Caballero, Julio, Clark, Shawn T., Coburn, Bryan, Zhang, Yu, Wang, Pauline W., Donaldson, Sylva L., Tullis, D. Elizabeth, Yau, Yvonne C. W., Waters, Valerie J., Hwang, David M., and Guttman, David S.

Abstract

ABSTRACTPulmonary infections caused by Pseudomonas aeruginosaare a recalcitrant problem in cystic fibrosis (CF) patients. While the clinical implications and long-term evolutionary patterns of these infections are well studied, we know little about the short-term population dynamics that enable this pathogen to persist despite aggressive antimicrobial therapy. Here, we describe a short-term population genomic analysis of 233 P. aeruginosaisolates collected from 12 sputum specimens obtained over a 1-year period from a single patient. Whole-genome sequencing and antimicrobial susceptibility profiling identified the expansion of two clonal lineages. The first lineage originated from the coalescence of the entire sample less than 3 years before the end of the study and gave rise to a high-diversity ancestral population. The second expansion occurred 2 years later and gave rise to a derived population with a strong signal of positive selection. These events show characteristics consistent with recurrent selective sweeps. While we cannot identify the specific mutations responsible for the origins of the clonal lineages, we find that the majority of mutations occur in loci previously associated with virulence and resistance. Additionally, approximately one-third of all mutations occur in loci that are mutated multiple times, highlighting the importance of parallel pathoadaptation. One such locus is the gene encoding penicillin-binding protein 3, which received three independent mutations. Our functional analysis of these alleles shows that they provide differential fitness benefits dependent on the antibiotic under selection. These data reveal that bacterial populations can undergo extensive and dramatic changes that are not revealed by lower-resolution analyses.IMPORTANCEPseudomonas aeruginosais a bacterial opportunistic pathogen responsible for significant morbidity and mortality in cystic fibrosis (CF) patients. Once it has colonized the lung in CF, it is highly resilient and rarely eradicated. This study presents a deep sampling examination of the fine-scale evolutionary dynamics of P. aeruginosain the lungs of a chronically infected CF patient. We show that diversity of P. aeruginosais driven by recurrent clonal emergence and expansion within this patient and identify potential adaptive variants associated with these events. This high-resolution sequencing strategy thus reveals important intraspecies dynamics that explain a clinically important phenomenon not evident at a lower-resolution analysis of community structure.

Published
2015
Full Text
View/download PDF

33. Conducting Effective Physician Performance Feedback: A Primer for Healthcare Leaders.

Author

Cheng AH, Manayathu J, Sinclair D, Tullis DE, and Bandiera G

Subjects
Canada, Humans, Leadership, Medical Audit, Patient Satisfaction, Patient Simulation, Physician-Patient Relations, Quality Indicators, Health Care, Clinical Competence, Feedback, Psychological, Physicians, Quality Improvement organization & administration
Abstract

Physician performance feedback (PPF) can help physicians gain insight into their practice, to identify areas for improvement, and to implement changes to improve care. There is increasing interest in the use of PPF in Canada. However, little is known about the different types of PPF methods and whether PPF can lead to improved physician performance and patient outcomes. We provide a primer for healthcare leaders interested in doing PPF by reviewing common PPF methods. We then describe our institution's experience with physician multi-source feedback and provide strategies to conduct meaningful PPF.

Published
2016
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results