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Your search keyword '"Tulpule, Sameer A."' showing total 29 results
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29 results on '"Tulpule, Sameer A."'

1. Jumping translocation of 3q21 in a patient with acute myeloid leukemia and poor clinical outcome

Author

Belnekar, Mamta, Virulkar, Shital, Tulpule, Sameer, and Kar, Bibhas

Subjects
Translocation (Genetics) -- Physiological aspects -- Health aspects -- Case studies, Health
Abstract

Jumping translocation (JT) is a cytogenetic event in which a donor chromosomal segment is translocated to two or more recipient chromosomes. We describe a case of a 75-year-old female patient diagnosed with acute myeloid leukemia (AML) with monocytic differentiation having acquired JT involving 3q21→3qter as a donor chromosomal segment with 12 different recipient chromosomes. Each abnormal clone had monosomy 7 and trisomy 8. Patients with JT have an adverse outcome, a high risk of disease progression, and an unfavorable prognosis. This is the sixth case of JT involving 3q21 and the first case having 12 different recipient chromosomes (15 chromosomal segments) along with monosomy 7 in all abnormal clones reported in the literature. Keywords: Acute myeloid leukemia, acquired, chromosome 3q21, jumping translocation, Author(s): Mamta Belnekar [1]; Shital Virulkar [1]; Sameer Tulpule [2]; Bibhas Kar (corresponding author) [1] INTRODUCTION Jumping translocations (JT) are rare cytogenetic alterations resulting from the nonreciprocal translocation of a [...]

Published
2024
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8. Impact of Donor-specific Anti-human Leukocyte Antigen Antibodies in Haploidentical Hematopoietic Stem-cell Transplantation: A Single-center Retrospective Study.

Author

Sawant, Rajesh B., Sen, Santanu, Tulpule, Sameer A., and Naker, Deepali Y.

Subjects
HLA-B27 antigen, GRAFT rejection, BLOOD grouping & crossmatching, CONFIDENCE intervals, LOG-rank test, RETROSPECTIVE studies, ACQUISITION of data, CASE-control method, RISK assessment, TREATMENT effectiveness, CANCER patients, HEMATOLOGIC malignancies, MEDICAL records, HEMAPHERESIS, SURVIVAL analysis (Biometry), KAPLAN-Meier estimator, DESCRIPTIVE statistics, HEMATOPOIETIC stem cell transplantation, ALLOCATION of organs, tissues, etc., PROGRESSION-free survival, DATA analysis software, PROPORTIONAL hazards models, EVALUATION
Abstract

Introduction: While donor-specific anti-human leukocyte antigen (HLA) antibodies (DSA) have been implicated in graft rejection in solid organ transplantation, their role in hematopoietic stem-cell transplantation (HSCT) remains unclear. Aim: The aim of this study is to study the role of DSA for proper donor selection and its effect in the setting of allogeneic HSCT. Methodology: HLA A, B, C, DRB1, and DQB1 high-resolution typing, and DSA cross match (XM) of patients (n = 73) and their prospective donors (n = 74) were assessed. A case--control study was designed retrospectively to evaluate the effect of pre- existing DSAs on engraftment. Thirty-five cases with 5/10 HLA alleles mismatches and 38 cases with full HLA matched, these two controls were selected for comparison. These were matched for disease, graft type, conditioning regimen, age, gender, blood group, and sensitizing events. DSAs were tested with solid-phase assay (Luminex 100/200 platform). Results: DSAs were detected in six of 35 patients (17%); however, donors selected for transplantation were all negative for DSA crossmatch. These six patients who underwent haploidentical (HI) transplants had antibodies against Class I and II. One patient carried antibodies against both classes. A patient who experienced primary graft failure had a second HI transplant. No other known factors that could negatively influence engraftment were associated with the development of graft failure in this patient. Conclusions: DSAs are not associated with graft rejection in patients undergoing HI stem-cell transplantation. Anti-HLA sensitization should be evaluated routinely in HSCT with HLA mismatched donors for a better outcome. [ABSTRACT FROM AUTHOR]

Published
2022
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11. Immune reconstitution following umbilical cord blood transplantation: IRES, a study of UK paediatric patients

Author

Girdlestone, John, primary, Raymond, Meera, additional, Shaw, Bronwen, additional, Tulpule, Sameer, additional, Devlia, Vikesh R., additional, Danby, Robert, additional, Ahyee, Trudy, additional, Saudemont, Aurore, additional, Hough, Rachael, additional, Veys, Paul, additional, Ruggeri, Annalisa, additional, Vora, Ajay, additional, Marks, David I., additional, Gibson, Brenda, additional, Wynn, Robert, additional, Madrigal, Alejandro, additional, and Navarrete, Cristina V., additional

Published
2020
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14. Total body irradiation in a case of thalassemia major with source to axis distance based planning: A case report

Author

Virkar, Mayuresh D., Chauhan, Rajkumar, Chadha, Pranav, Talapatra, Kaustav, Rodrigues, Reuben Jake, Shrivastava, Amrita, Sen, Santanu, Tulpule, Sameer, Virkar, Mayuresh D., Chauhan, Rajkumar, Chadha, Pranav, Talapatra, Kaustav, Rodrigues, Reuben Jake, Shrivastava, Amrita, Sen, Santanu, and Tulpule, Sameer

Abstract

Background: The use of total body radiation (TBI) before hematopoietic stem cell transplantation (HSCT) would increase the engraftment without transplant-related morbidity or mortality among Thalassemia major (TM) cases. Case presentation: A 2-year-old female child, diagnosed with TM was scheduled for haploidentical allogenic transplant-based protocol, and after that, based on protocol she was scheduled to undergo a single session of TBI as a conditioning regimen before haploidentical allogenic hematopoietic stem cell tranplant. A total dose of 4 Gy was administered.. The incidence of graft failure was reduced as TBI was used before allogeneic stem cell transplantation. TBI provided a uniform dose of radiation to the entire body, penetrating areas such as the central nervous system (CNS) and testes. Conclusion: Total Body Irradiation with the SAD technique is the most effective way of treatment. As it is comfortable for the patient to undergo, easily reproducible, and it helps to achieve a uniform dose distribution.

Published
2020

21. A Multicentre Retrospective UK Study Detailing Onset Of Graft Verus Host Disease, Responses To Treatment and Outcome After Donor Lymphocyte Infusion Following Haemopoietic Stem Cell Transpantation: Rates Of GVHD Are High But Death From GVHD Infrequent

Author

Scarisbrick, Julia J, primary, Dignan, Fiona L, additional, Tulpule, Sameer, additional, Das gupta, Emma, additional, Shah, Gulnaz, additional, Pagliuca, Antonio, additional, Malladi, Ram, additional, and Raj, Kavita, additional

Published
2013
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24. High Absolute T Regulatory Cell Counts and Resistance of CD8 Central Memory Cells to Killing by Fludarabine Predicts for Poor Responses to DLI in the Context of a Pre-DLI Lymphoreduction Strategy

Author

Tulpule, Sameer, primary, Russell, Nigel H., additional, Byrne, Jenny, additional, Das-Gupta, Emma P, additional, Ethell, Mark E, additional, Figueroa, Daniel, additional, Madrigal, J. Alejandro, additional, Morgan, Gareth J, additional, Potter, Michael, additional, and Shaw, Bronwen E., additional

Published
2011
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25. Results of a Prospective Clinical Trial of Pre-DLI Lymphoreduction Using Oral Fludarabine In Patients with Mixed Chimerism Post Allogeneic Transplant.

Author

Shaw, Bronwen E., primary, Byrne, Jenny, additional, Das-Gupta, Emma, additional, Ethell, Mark, additional, Figueroa, Daniel, additional, Madrigal, J. Alejandro, additional, Morgan, Gareth J, additional, Tulpule, Sameer, additional, Potter, Michael, additional, and Russell, Nigel H., additional

Published
2010
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27. B Cell Post Transplant Lymphoproliferative Disorder Complicating Solid Organ Transplantation (B-PTLD): A Single Centre Review Reporting 1) Results with Chemo-Immunotherapy (CHOP/R) and 2) the Predictive Ability of FDG-PET Scanning To Correlate with Long Term Overall Survival.

Author

Tulpule, Sameer, primary, Mikhaeel, George, primary, Kazmi, Majid, primary, Nunan, Tom, primary, Van Der Walt, John, primary, Goldsmith, David, primary, and Fields, Paul A., primary

Published
2005
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28. Immune Reconstitution in Cord Blood Transplantation.

Author

Tulpule, Sameer and Shaw, Bronwen E.

Subjects
*CORD blood transplantation, *STEM cell transplantation, *IMMUNE reconstitution inflammatory syndrome, *IMMUNOLOGIC diseases, *IMMUNITY, *THERAPEUTICS
Abstract

The article discusses the use of umbilical cord blood (UCB) as an alternative source of stem cells for transplantation. It discusses the biology and functional features of CB immune cells. Clinical studies which examined immune reconstitution (IR) after cold blood transplantation (CBT) are examined. Also tackled are developments to improve IR.

Published
2012

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