1. Enhanced circulating levels of CD3 cells-derived extracellular vesicles in different forms of pulmonary hypertension
- Author
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Djuro Kosanovic, Ujjwal Deo, Henning Gall, Balachandar Selvakumar, Susanne Herold, Astrid Weiss, Aleksandar Petrovic, Akylbek Sydykov, Hossein Ardeschir Ghofrani, and Ralph Theo Schermuly
- Subjects
Diseases of the circulatory (Cardiovascular) system ,RC666-701 ,Diseases of the respiratory system ,RC705-779 - Abstract
It has been shown previously that increased circulating endothelial cells-derived extracellular vesicles represent an important pathological attribute of pulmonary hypertension. Although it is a well-known fact that inflammatory cells may also release extracellular vesicles, and pulmonary hypertension is a disease associated with abnormal inflammation, there is no profound knowledge with regard to the role of inflammatory cells-derived extracellular vesicles. Therefore, our study demonstrated that circulating levels of extracellular vesicles derived from T-cells are enhanced in various pulmonary hypertension forms and that endothelial cells-derived extracellular vesicles may have distinctive profiles in different clinical subgroups of pulmonary hypertension, which still remains as a poorly treatable and life-threatening disorder.
- Published
- 2019
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