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1. Gemcitabine or Gemcitabine and Cisplatin in the Treatment of Advanced Pancreatic Cancer (GIP-1)

Author: Gruppo Oncologico Italia Meridionale, Gruppo Italiano per lo studio dei Carcinomi dell'Apparato Digerente, Gruppo Oncologico Italiano di Ricerca Clinica, Cattedra di Endocrinochirurgia, Università di Verona, and Giuseppe Colucci
Published: 2008

2. Ankle-Brachial Index and cardiovascular events in atrial fibrillation The ARAPACIS Study

Author: Violi, F., Davi, G., Proietti, M., Pastori, D., Hiatt, W. R., Corazza, G. R., Perticone, F., Pignatelli, P., Farcomeni, A., Vestri, A. R., Lip, G. Y. H., Basili, S, ARAPACIS (Atrial Fibrillation Registry for Ankle-Brachial Index Prevalence Assessment-Collaborative Italian Study) STUDY Investigators. Alessandri C. (Dipartimento di Scienze e Biotecnologie Medico-Chirurgiche, Sapienza-Università di Roma), Serviddio G. (Department of Medical and Surgical Sciences, University of Foggia), (UOC Medicina Generale, Fascetti S., USL 12 Viareggio, Toscana), (UOC Medicina Interna I, Palange P., Dipartimento di Sanità Pubblica, e Malattie Infettive, Sapienza-Università di Roma), Greco, E., (Medicina 3, Bruno G., Department of Medical Sciences, Città della Salute e della Scienza, A. O., University of Turin), Averna, M., (Dipartimento Biomedico di Medicina Interna e Specialistica, Giammanco A., Università di Palermo), Sposito P. (Azienda Ospedaliera Ospedali Riuniti Papardo Piemonte, Messina), De Cristofaro, R., (Istituto di Medicina Interna e Geriatria, De Gennaro L., Centro Emostasi, e Trombosi, Gemelli, Policlinico A., Roma), Carulli, L., (UO di Medicina a Indirizzo Nutrizionistico e Metabolico, Pellegrini E., Università degli Studi di Modena e Reggio Emilia), Dipartimento Integrato di Medicina Endocrinologia Metabolismo e Geriatria., Cominacini, L., Mozzini, C., (Dipartimento di Medicina, Pasini A. F., Sezione di Medicina Interna, D, Università di Verona), Sprovieri, M., (UOC Medicina d'Urgenza e PS, Spagnuolo V., Stabilimento Ospedaliero dell'Annunziata, Cosenza), (UOC Medicina Interna per l'Urgenza, Cerqua G., S Giovanni Addolorata, Ao, Cerasola G., Mulé G. (Università degli Studi di Palermo), Barbagallo, M., Lo Sciuto, S., (UOC di Geriatria e Lungodegenza, Monteverde A., Azienda Ospedaliera Universitaria Policlinico, Aoup, Palermo), Saitta, A., (UOC Medicina Interna, Lo Gullo A., Università di Messina), Malatino, L., Cilia, C., Terranova, V., (Clinica Medica, Pisano M., Ospedale, Cannizzaro, Università degli Studi di Catania), Pinto, A., Di Raimondo, D., Tuttolomondo, A., (Internal Medicine and Cardio-Angiology Ward, Conigliaro R., Department of Biomedicine and Internal Medicine, University of Palermo), Signorelli S. (Dipartimento di Medicina Interna e Patologia, Università degli Studi di Catania), De Palma, D., Galderisi, M., (Dipartimento di Medicina Clinica e Sperimentale, Cudemo G., AUP Federico II di Napoli), Galletti, F., (Dipartimento di Medicina Clinica e Chirurgia, Fazio V., Università di Napoli Federico II), De Luca, N., (Centro Ipertensione, Meccariello A., AUO Federico II, Napoli), Caputo, D., (UO Medicina Interna, De Donato M. T., Azienda Ospedaliera Universitaria San Giovanni di Dio, e Ruggi D'Aragona, Salerno), Iannuzi, A., (Divisione di Medicina Interna, Bresciani A., Cardarelli, Osp. A., (V Divisione Medicina Interna ed Immunoallergologia, Giunta R., Policlinico, Sun, Utili, R., (Medicina Infettivologica e dei Trapianti, Iorio V., Seconda Università di Napoli, AORN dei Colli-Monaldi), Adinolfi, L. E., Sellitto, A., (Medicina Interna, Iuliano N., Ospedale di Marcianise), Bellis, P., (UOC Medicina Interna e di Urgenza e Pronto Soccorso, Tirelli P., del Loreto Nuovo, P. O. S. M., Loreto, Mare), (Clinica Medica 5, Sacerdoti D., Dipartimento di Medicina DIMED, Università degli Studi di Padova), (UO Medicina Interna Arezzo, Vanni D., Ospedale San Donato, Azienda USL, 8 Arezzo), Iuliano, L., Ciacciarelli, M., (Department of Medico-Surgical Sciences and Biotechnology, Pacelli A., Vascular Biology, Mass Spectrometry Lab, Sapienza-University of Rome), Palazzuoli A. (UOS Malattie Cardiovascolari Dipartimento di Scienze Mediche Chirurgiche e Neuroscienze, Università di Siena), Cacciafesta, M., Gueli, N., Lo Iacono, C., Brusco, S., (UOC di Medicina Geriatrica e Riabilitazione, Verrusio W., Sapienza-Università di Roma, Nobili, L., Tarquinio, N., (UO Medicina 'SS Benvenuto e Rocco', Pellegrini F., Dipartimento di Medicina Interna, Asur, Marche, Area Vasta, n. 2., ex ZT 7), (UOS Breve Osservazione, Vincentelli G. M., Calibita 'Fatebenefratelli' Isola Tiberina, Ospedale S. G., Ravallese, F., (UOC Medicina Interna, Santini C., Ospedale, Vannini, Letizia, C., Petramala, L., (UOD Ipertensione Secondaria, Zinnamosca L., Dipartimento di Medicina Interna, e Specialità Mediche, Minisola, S., Cilli, M., Savoriti, C., (UOC Medicina Interna F e Malattie Metaboliche dell'osso- Sapienza-Università di Roma), Colangelo L., Falaschi, P., Martocchia, A., (UO Geriatria, Pastore F., Andrea, Azienda Ospedaliera S., Facoltà diMedicina, e Psicologia, Bertazzoni, G., (UOC Medicina d’Urgenza, Attalla El Halabieh E., Dipartimento di Emergenza ed Accettazione, Paradiso, M., Lizzi, E. M., (Ospedale San Giovanni Battista, Timmi S., Ordine di Malta, (Medicina Interna II, Battisti P., Ospedale San Giovanni-Addolorata, (UOC Medicina Interna, Cerci S., Ospedali Riuniti Frascati, Marino), (UOC Cardiologia-UTIC, Ciavolella M., Ospedale di Frascati, (Centro dell’Ipertensione Arteriosa e delle Malattie Metaboliche e Renali, Di Veroli C., Casa di Cura 'San Domenico', Malci, F., (UOC di Medicina Interna, De Ciocchis A., Ospedale, ASL Roma, G, Subiaco), Abate, D. (Az., Castellino, P., Zanoli, L., (UOC Medicina Interna, Fidone F., Dipartimento di Medicina Clinica, e Sperimentale, Mannarino, E., Pasqualini, L., (Medicina Interna, Oliverio G., Università degli Studi di Perugia), Pende, A., (Clinica di Medicina Interna 1, Artom N., Università di Genova, San Martino - IST), IRCCS Az. Osp. Univ., Ricchio, R., (UOC Geriatria, Fimognari F. L., Azienda Ospedaliera di Cosenza, Alletto, M., (Unità Operativa di Medicina, Messina S., Elia, Ospedale S., Caltanissetta), Sesti, G., Arturi, F., Fiorentino, T. V., (Università degli Studi, Pedace E., UOC Medicina Interna, Policlinico Universitario 'Mater Domini'), Scarpino, P. E., Carullo, G., Maio, R., (Cattedra di Medicina Interna, Sciacqua A., UO Malattie Cardiovascolari, Campus Universitario di Germaneto, Università Magna Graecia di Catanzaro), Frugiuele, P., (UOC Medicina Interna e Reumatologia, Spagnuolo V., Stabilimento Ospedaliero Annunziata, Azienda Ospedaliera Cosenza), (UO Lungodegenza, Battaglia G., Serra San Bruno, S. O., ASP Vibo Valentia), Atzori, S., (Clinica Medica, Delitala G., Aou, Sassari), Angelucci, E., (UOC di Clinica Medica, Sestili S., PO Clinicizzato di Chieti), Traisci, G., (UOC Medicina Interna 2, De Feudis L., PO di Pescara), Di Michele, D., (UOC Medicina Interna, Fava A., Asl, Teramo), Balsano, C., (Dipartimento di Medicina Interna e Sanità Pubblica, De Ciantis P., Università, dell'Aquila), Desideri, G., (UOC Geriatria e Lungodegenza Geriatrica, Camerota A., Dipartimento Medico ORM, Avezzano), Po, Mezzetti M. (UOC Medicina Interna Ospedale del Casentino-Direttore Dr. Emilio Santoro, AUSL8 Arezzo), Gresele, P., Vedovati, C., (Dipartimento di Medicina Interna, Fierro T., Sezione di Medicina Interna, e Cardiovascolare, Università di Perugia), (Centro Aterosclerosi, Puccetti L., Trombosi, e Coagulopatie, Università degli Studi di Siena, Azienda Ospedaliero-Universitaria Senese), Bertolotti, M., (UO Geriatria, Mussi C., Boddi, M., Savino, A., Contri, S., (Dipartimento di Medicina Sperimentale e Clinica, Degl'Innocenti G., Università degli Studi di Firenze), Saller, A., (Clinica Medica 1, Fabris F., Medicina Interna CLOPD, Departement of Medicine DIMED, University of Padova), Pesavento, R., Filippi, L., (Dipartimento di Scienze Cardiologiche, Vedovetto V., Toraciche, e Vascolari, Clinica Medica, 2, Azienda Ospedaliera-Università di Padova), (Clinica Medica IV, Puato M., Dipartimento di Medicina, Azienda Ospedaliera Universitaria Padova, Padova), Fabris, F., (UOA Medicina, Treleani M., Policlinico, Universitario, De Luca, E., De Zaiacomo, F., (Clinica Geriatrica, Giantin V., Università di Padova), (Medicina Interna 1, Semplicini A., Giovanni e Paolo, Ospedale SS., Venezia), Minuz, P., (Sezione di Medicina Interna C, Romano S., Università di Verona, Aoui, Verona), Fantin, F., (Dipartimento di Medicina, Manica A., Sezione di Geriatria, Stockner, I., Pattis, P., Wiedermann, Gutmann B. (Divisione di Medicina Interna-Direttore Prof. J., Ospedale Centrale di Bolzano), Catena, C., Colussi, G., (Clinica Medica, Sechi L. A., Dipartimento di Scienze Mediche Sperimentali, e Cliniche, Università di Udine, Italy), Annoni, G., Bruni, A. A., (Clinica Geriatrica, Castagna A., Università degli Studi di Milano-Bicocca, Dipartimento di Medicina, e Chirurgia, AO San Gerardo, Monza), (Medicina Interna 1, Spinelli D., Dipartimento di Scienze Cliniche, e di Comunità, Fondazione, Irccs, Università di Milano), (Clinica Medica I, Miceli E., Reparto, 11, IRCCS Policlinico San Matteo di Pavia), Schinco, G., (UOC Geriatria, Spreafico S., Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico), (UOC Medicina Interna, Secchi B., Ospedale, Bassini, Milano), Vanoli, M., Casella, G., (SC Medicina Interna, Pulixi E. A., Azienda Ospedaliera della Provincia di Lecco, Ospedale di Merate, Lecco), Sansone, L., (UOC Medicina, Serra M. G., Panico', Azienda Ospedaliera 'Cardinale G., Tricase, (Lecce), Longo, S., (UOC Medicina Interna, Antonaci S., Azienda Ospedaliera Policlinico, Bari), Belfiore, A., Frualdo, M., Palasciano, G., Murri'- Bari), Ricci L. (Clinica Medica 'A., (Struttura Complessa di Medicina Interna, Ventrella F., Cerignola, Asl, Foggia), (UOC Medicina Interna, Bianco C., Tropea), Santovito, D., (Centro di Eccellenza Europeo e di Riferimento Regionale per l'Aterosclerosi, Cipollone F., l'Ipertensione Arteriosa, e le Dislipidemie, Università, Chieti), Nicolai, S., (UO Medicina Interna, Salvati F., Ospedale di Ortona, ASL 02 Abruzzo), Rini, G. B., (UOC Medicina Interna ed Ipertensione, Scozzari F., Dipartimento Biomedico di Medicina Interna, e Specialistica, Giaccone' di Palermo), Policlinico 'P., Muiesan, M. L., Salvetti, M., (Dipartimento di Scienze Cliniche e Sperimentali, Bazza A., Università di Brescia, 2° Medicina Generale Spedali Civili), Picardi, A., Vespasiani-Gentilucci, U., (Medicina Interna e Epatologia, De Vincentis A., Università Campus Bio-Medico, Cosio, P., (Medicina Interna 1, Terzolo M., Dipartimento di Scienze Cliniche, e Biologiche, AOU San Luigi Gonzaga, Università di Torino), Madaffari, B., (UO Medicina Interna, Parasporo B., Azienda Ospedaliera Bianchi Melacrino Morelli, Reggio, Calabria), Fenoglio, L., Bracco, C., (SC Medicina Interna, Melchio R., Croce e Carle, AO S., Cuneo), Gentili, T., (Medicina Generale - Settore Subintensivo, Salvi A., Azienda Ospedaliero- Universitaria, Ancona), (Medicina Generale - Settore Ordinario, Nitti C., Azienda, Ospedaliero-Universitaria, Gabrielli, A., (Clinica Medica, Martino G. P., Capucci, A., Brambatti, M., (Clinica di Cardiologia, Sparagna A., Ospedale, Torrette, (UO Medicina Generale IV, Tirotta D., Ospedale, Cervesi, Cattolica), Andreozzi, P., Ettorre, E., Viscogliosi, G., Servello, A., (Area Geriatria, Musumeci M., DAI Medicina Interna, Rossi Fanelli, F., Delfino, M., (UOC Medicina Interna H, Giorgi A., Sapienza- Università di Roma), Glorioso, N., Melis, G., Marras, G., (Ambulatorio Ipertensione Arteriosa e Patologie Correlate, Matta M., (UOC Medicina Interna, Sacco A., PO Madonna delle Grazie, Matera), Stellitano, E., (UO Medicina, Scordo A., PO 'Tiberio Evoli', Melito Porto Salvo), Russo, F., (UOC Medicina Generale di Rogliano, Caruso A. A., AO di Cosenza), Porreca, E., (UO Medicina Interna e Geriatria, Tana M., D'Annunzio, Università G., Chieti-Pescara), Ferri, C., (Divisione di Medicina Interna e Nefrologia - Ospedale San Salvatore, Cheli P., Dipartimento, Mesva, (Clinica Medica 'Murri', Portincasa P., Dipartimento di Scienze Mediche, e Oncologia Umana, Università degli Studi di Bari), Muscianisi G. (ASP Reggio Calabria, Saline Joniche), Giordani, S., (Dipartimento di Scienze Mediche e Chirurgiche, Stanghellini V., Università degli Studi di Bologna), Sabbà C. (UOC Geriatria e Centro di assistenza e ricerca sovraziendale per le malattie rare, Bari), Mancuso, G., Bartone, M., (UOC Medicina Interna, Calipari D., Presidio, Ospedaliero, ASP di Catanzaro), Arcidiacono, G., (UOC Cardiologia e UTIC, Bellanuova I., Catania), Ferraro M., Marigliano G. (ASP Cosenza), Cozzolino, D., Lampitella, A., (Dipartimento di Internistica Clinica e Sperimentale, Acri V., Seconda Università di Napoli), Galasso, D., Mazzei, F., (RSA Madonna di Porto Gimigliano, Galasso S., Catanzaro), (Azienda Ospedaliera della Provincia di Pavia, Buratti A., UO Medicina Interna, Ospedale, Civile, Casorate, Primo, Pavia), Porta, M., (SC Medicina Interna 1U, Brizzi M. F., Azienda, Ospedaliera, Torino), Fattorini, A., Sampietro, F., (Servizio di Coagulazione ed Unità Ricerca Trombosi, D’Angelo A., IRCCS Ospedale San Raffaele, Manfredini, R., Pala, M., (UOC Clinica Medica, Fabbian F., Anna, Azienda Ospedaliera- Universitaria S., Ferrara), Moroni, C., Valente, L., (Laboratorio di Ecocardiografia- Cardiologia Preventiva, Lopreiato F., DAI Cuore, e Grossi Vasi, (UOC Medicina Interna, Parente F., Lecce), (Immunologia Clinica A, Granata M., Moia, M., (Fondazione IRCCS Ca'Granda, Braham S., Ospedale Maggiore Policlinico, Rossi, M., (Dipartimento di Medicina Clinica e Sperimentale, Pesce M., Università di Pisa), Gentile, A., (UO Medicina, Catozzo V., Ldp, Loreto, Baciarello, G., (UOC Cardiologia Preventiva e Riabilitativa, Cosimati A., Ageno, W., Rancan, E., (Dipartimento di Medicina Clinica e Sperimentale, Guasti L., Università, Dell'Insubria, Varese), Ciccaglioni, A., Negri, S., (Centro Elettro-Stimolazione Cardiaca, Polselli M., Prisco, D., (SOD Patologia Medica, Marcucci R., Aou, Careggi, Firenze), Ferro, D., Cangemi, R., Perri, L., Polimeni, L., Catasca, E., Vicario, T., Russo, R., Saliola, M., Del Ben, M., Angelico, F., Calvieri, C., Bucci, T., (I Clinica Medica, Baratta F., Migliacci, R., Medicina Interna, Porciello G. (S. C., Ospedale della Valdichiana, Cortona, Usl, 8 Arezzo), (Dipartimento BioMedico di Medicina Interna e Specialistica, Corrao S., Università degli Studi di, Palermo). Simi Young Internists (GIS) Group: Anzaldi M., Bazzini, C., Bianchi, P. I., Boari, B., Buonauro, A., Buttà, C., Buzzetti, E., Calabria, S., Capeci, W., Caradio, F., Carleo, P., Carrabba, M. D., Castorani, L., Cecchetto, L., Cicco, S., Cimini, C., Colombo, B. M., De Giorgi, A., De Vuono, S., Del Corso, L., Denegri, A., Di Giosia, P., Durante Mangoni, E., Falsetti, L., Forgione, A., Giorgini, P., Grassi, D., Grembiale, A., Hijazi, D., Iamele, L., Lorusso, G., Marchese, A., Marra, A. M., Masala, M., Miceli, G., Montebianco Abenavoli, L., Murgia, G., Naccarato, P., Padula, D., Pattoneri, P., Perego, F., Pesce, P., Piano, S., Pinna, M., Pinto, D., Pretti, V., Pucci, G., Raparelli, V., Salinaro, F., Salzano, A., Santilli, F., Scarpini, F., Scicali, R., Sirico, D., Suppressa, P., Talia, M., Tassone, E. J., Torres, D., Vazzana, N., Vecchio, C. R., Vidili, G., Vitale, F., Zaccone, V., Alessandri, C., Serviddio, G., Palange, P, Greco, E, Bruno, G, Averna, M, Giammanco, A, Sposito, P, De Cristofaro, R., De Gennaro, L, Carulli, L, Pellegrini, E, Cominacini, L, Mozzini, C, Pasini, Af, Sprovieri, M, Spagnuolo, V, Cerqua, G, Cerasola, G, Mulé, G, Barbagallo, M, Lo Sciuto, S, Monteverde, A, Saitta, A, Lo Gullo, A, Malatino, L, Cilia, C, Terranova, V, Pisano, M, Pinto, A, Di Raimondo, D, Tuttolomondo, A, Conigliaro, R, Signorelli, S, De Palma, D, Galderisi, M, Cudemo, G, Galletti, F, Fazio, V, De Luca, N, Meccariello, A, Caputo, D, De Donato, Mt, Iannuzi, A, Bresciani, A, Giunta, R, Utili, R, Iorio, V, Adinolfi, Luigi Elio, Sellitto, A, Iuliano, N, Bellis, P, Tirelli, P, Sacerdoti, D, Vanni, D, Iuliano, L, Ciacciarelli, M, Pacelli, A, Palazzuoli, A, Cacciafesta, M, Gueli, N, Lo Iacono, C, Brusco, S, Verrusio, W, Nobili, L., Tarquinio, N., Pellegrini, F, Vincentelli, G. M., Ravallese, F, Santini, C, Letizia, C, Petramala, L, Zinnamosca, L, Minisola, S., Cilli, M, Savoriti, C, Colangelo, L, Falaschi, P, Martocchia, A, Pastore, F., and DURANTE MANGONI, Emanuele
Subjects: Male, Risk, ABI, ARAPACIS, Atrial fibrillation, Myocardial infarction, Vascular events, Hematology, medicine.medical_specialty, Aged, Aged, 80 and over, Ankle Brachial Index, Atrial Fibrillation, Female, Follow-Up Studies, Humans, Italy, Middle Aged, Predictive Value of Tests, Prospective Studies, Survival Analysis, Vascular Diseases, Population, Socio-culturale, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, atrial fibrillation, ABI, ARAPACIS, myocardial infarction, vascular events, Interquartile range, Internal medicine, myocardial infarction, vascular events, 80 and over, Medicine, Cumulative incidence, 030212 general & internal medicine, education, Prospective cohort study, Stroke, education.field_of_study, business.industry, Hazard ratio, medicine.disease, Cardiology, business, Settore SECS-S/01 - Statistica
Abstract: SummaryAtrial fibrillation (AF) patients are at high risk for thrombotic and vascular events related to their cardiac arrhythmia and underlying systemic atherosclerosis. Ankle-Brachial Index (ABI) is a non-invasive tool in evaluating systemic atherosclerosis, useful in predicting cardiovascular events in general population; no data are available in AF patients. ARAPACIS is a prospective multicentre observational study performed by the Italian Society of Internal Medicine, analysing association between low ABI (≤0.90) and vascular events in NVAF out- or in-patients, enrolled in 136 Italian centres. A total of 2,027 non-valvular AF (NVAF) patients aged > 18 years from both sexes followed for a median time of 34.7 (interquartile range: 22.0–36.0) months, yielding a total of 4,614 patient-years of observation. Mean age was 73 ± 10 years old with 55% male patients. A total of 176 patients (8.7%) experienced a vascular event, with a cumulative incidence of 3.81%/patient-year. ABI≤ 0.90 was more prevalent in patients with a vascular event compared with patients free of vascular events (32.2 vs 20.2%, p< 0.05). On Cox proportional hazard analysis, ABI≤ 0.90 was an independent predictor of vascular events (hazard ratio (HR): 1.394, 95% confidence interval (CI): 1.042–1.866; p=0.02), vascular death (HR: 2.047, 95% CI: 1.255-3.338; p=0.004) and MI (HR: 2.709, 95%> CI: 1.485-5.083; p=0.001). This latter association was also confirmed after excluding patients with previous MI (HR: 2.901, 95% CI: 1.408-5.990, p=0.004). No association was observed between low ABI and stroke/transient ischaemic attack (p=0.91). In conclusion, low ABI is useful to predict MI and vascular death in NVAF patients and may independently facilitate cardiovascular risk assessment in NVAF patients.Note: The review process for this paper was fully handled by C. Weber, Editor in Chief.Listed in the Supplementary Online Appendix Material which is available online at www.thrombosis-online.com.
Published: 2016

3. 'FRANÇAIS, ENCORE UN EFFORT'. UN EXCURSUS SULLA LETTERATURA EROTICA

Author: Direzione, Angeli, Giovanna, Collini, Patrizio, Pizzorusso, Claudio, Scientifico, Comitato, Silvia Bigliazzi (Letteratura inglese, Università di Verona, Louise George Clubb (Letterature comparate, Università di Berkeley, Claudia Corti (Letteratura inglese, Università di Firenze, Elena Del Panta (Letteratura francese, Università di Firenze, Michel Delon (Letteratura francese, Università Paris Sorbonne, Michela Landi (Letteratura francese, Università di Firenze, Ivanna Rosi (Letteratura francese, Università di Pisa, Helmut J. Schneider (Letteratura tedesca, Università di Bonn, Valerio Viviani (Letteratura inglese, Università della Tuscia, Redazionale, Coordinamento, Landi, Michela, and Viviani, Valerio
Subjects: letteratura erotica francese, XVIII secolo, Lumières, autori libertini, romanzo nero
Published: 2017

4. Prevalence of peripheral artery disease by abnormal ankle-brachial index in atrial fibrillation: implications for risk and therapy

Author: Violi, Francesco, Daví, Giovanni, Hiatt, William, Lip, Gregory Y. H., Corazza, Gino R., Perticone, Francesco, Proietti, Marco, Pignatelli, Pasquale, Vestri, Anna R., Basili, Stefania, Desideri, ARAPACIS Study Investigators Alessandri Cesare (Dipartimento di Scienze e Biotecnologie Medico-Chirurgiche, G., Sapienza-Università di Roma), Serviddio Gaetano (Department of Medical and Surgical Sciences, University of Foggia), Fascetti Stefano (UOC Medicina Generale, USL 12 Viareggio, Toscana), Serra, Pietro, Palange Paolo(UOC Medicina Interna, I, Dipartimento di Sanità Pubblica, e Malattie Infettive, Greco, Eleonora, Bruno Graziella (Medicina, 3, Department of Medical Sciences, Città della Salute e della Scienza, A. O., University of Turin), Averna, Maurizio, Giammanco Antonina (Dipartimento Biomedico di Medicina Interna, e Specialistica (DIBIMIS), Università di Palermo), Sposito Pietro (Azienda Ospedaliera Ospedali Riuniti Papardo Piemonte, Messina), De Cristofaro Raimondo, De Gennaro Leonardo(Istituto di Medicina Interna, e Geriatria, Centro Emostasi, e Trombosi, Gemelli, Policlinico A., Roma), Loria, Paola, Pellegrini Elisa(Medicina Interna ad Indirizzo Metabolico, – NOCSAE Baggiovara, Department of Internal Medicine, Endocrinology, Metabolism and Geriatrics, Università degli Studi di Modena, e Reggio Emilia), Cominacini, Luciano, Mozzini Chiara (Dipartimento di Medicina, Sezione di Medicina Interna, D, Università di Verona), Sprovieri, Mario, Spagnuolo Vitaliano (UOC Medicina d'Urgenza, e PS, Stabilimento Ospedaliero dell'Annunziata, Cosenza), Cerqua Giannantonio (UOC Medicina Interna per l'Urgenza, S Giovanni Addolorata, Ao, Cerasola Giovanni, Mulé Giuseppe (Università degli Studi di Palermo), Barbagallo, Mario, Lo Sciuto Salvatore, Monteverde Alfredo(UOC di Geriatria, e Lungodegenza, Azienda Ospedaliera Universitaria Policlinico, Aoup, Palermo), Saitta, Antonino, Lo Gullo Alberto (UOC Medicina Interna, Università di Messina), Malatino, Lorenzo, Cilia Chiara (Clinica Medica, Ospedale, Cannizzaro, Università degli Studi di Catania), Licata, Giuseppe, Tuttolomondo, Antonino, Conigliaro Roberta (UOC Medicina Interna, e Cardioangiologia, Dipartimento Biomedico di Medicina Interna, e Specialistica, Università degli Studi di Palermo), Pinto, Antonio, Di Raimondo Domenico (UOC Medicina Vascolare, Dipartimento Biomedico di Medicina Interna e Specialistica, (Di. Bi. M. I. S. )., Signorelli, Santo, Anzaldi Massimiliano (Dipartimento di Medicina Interna, e Patologia, Università degli studi di Catania), De Palma Daniela, Galderisi, Maurizio, Cudemo Giuseppe (Dipartimento di Medicina Clinica, e Sperimentale, AUP Federico II di Napoli), Galletti, Ferruccio, Fazio Valeria(Dipartimento di Medicina Clinica, e Chirurgia, Università di Napoli Federico II), De Luca Nicola, Meccariello Alfonso (Centro Ipertensione, AUO Federico II, Napoli), Caputo, Dario, De Donato Maria Teresa (UO Medicina Interna, Azienda Ospedaliera Universitaria San Giovanni di Dio, e Ruggi D'Aragona, Salerno), Iannuzi, Arcangelo, Bresciani Alessandro (Divisione di Medicina Interna, Cardarelli, Osp. A., Giunta, Riccardo, Cimini Claudia (V Divisione Medicina Interna ed Immunoallergologia, Policlinico, Sun, Utili, Riccardo, Durante Mangoni Emanuele, Agrusta Federica (Medicina Infettivologica, e dei Trapianti, Monaldi, Ao, Sun, Napoli), Adinolfi Luigi, E., Sellitto, Cristiana, Restivo Luciano (Medicina Interna, Seconda Università di Napoli, Ospedale di Marcianise), Bellis, Paolo, Tirelli Paolo (UOC Medicina Interna e di Urgenza, e Pronto Soccorso, del Loreto Nuovo, P. O. S. M., Loreto, Mare), Sacerdoti, David, Pesce Paola (Clinica Medica, 5, Dipartimento di Medicina DIMED, Università degli Studi di Padova), Vanni Dino (UO Medicina Interna Arezzo, Ospedale San Donato, Azienda USL, 8 Arezzo), Iuliano, Luigi, Ciacciarelli, Marco, Pacelli Antonio (Department of Medico-Surgical Sciences and Biotechnology, Vascular Biology, Mass Spectrometry Lab, Sapienza-University of Rome), Palazzuoli Alberto (Sezione Cardiologia, Dipartimento di Medicina Interna, e Malattie Metaboliche, Università di Siena, Ospedale Le Scotte), Cacciafesta, Mauro, Gueli Nicola (UOC di Medicina Geriatrica, e Riabilitazione, Sapienza- Università di Roma, Capeci, William, Tarquinio, Nicola, Pellegrini Francesco (UO Medicina 'SS Benvenuto, e Rocco', Dipartimento di Medicina Interna, Asur, Marche, Area Vasta, n. 2., ex ZT 7), Vincentelli Giovanni Maria (UOS Breve Osservazione, Calibita 'Fatebenefratelli' Isola Tiberina, Ospedale S. G., Ravallese, Ferdinando, Santini Claudio (UOC Medicina Interna, Ospedale, Vannini, Letizia, Claudio, Petramala, Luigi, Zinnamosca Laura (UOD Ipertensione Secondaria, Dipartimento di Medicina Interna, e Specialità Mediche, Cilli, Mirella, Savoriti Claudio (UOC Medicina Interna F, e Malattie Metaboliche Dell'osso-Direttore Minisola Salvatore, Falaschi, Paolo, Martocchia, Antonio, Stefanelli Manuela (UO Geriatria, Andrea, Azienda Ospedaliera S., Facoltà di Medicina, e Psicologia, Marigliano, Vincenzo, Lo Iacono Cristina, Brusco Simona (Centro di Ricerca Interdipartimentale Scienze dell’Invecchiamento, Bertazzoni, Giuliano, Attalla El Halabieh Elias (UOC Medicina d’Urgenza, Dipartimento di Emergenza ed Accettazione, Paradiso, Michele, Lizzi Eugenio Maria, Timmi Stefano (Ospedale San Giovanni Battista, Ordine di Malta, Battisti Paola (Medicina Interna II, Ospedale San Giovanni-Addolorata, Cerci Sabina (UOC Medicina Interna, Ospedali Riuniti Frascati, Marino), Ciavolella Massimo (UOC Cardiologia-UTIC, Ospedale di Frascati, Di Veroli Claudio (Centro dell’Ipertensione Arteriosa e delle Malattie Metaboliche, e Renali, Casa di Cura 'San Domenico', Malci, Francesco, De Ciocchis Anita (UOC di Medicina Interna, Ospedale, ASL Roma, G, Subiaco), Abate, Damiano(Az., Castellino, Pietro, Curto, Irene, Vecchio Claudia (UOC Medicina Interna, Dipartimento di Scienze Mediche, e Pediatriche, Mannarino, Elmo, Pasqualini, Leonella, Fattori Chiara (Medicina Interna, Angiologia, e Malattie da Arteriosclerosi, Università degli Studi di Perugia), Pende, Aldo, Denegri, Andre, Artom Nathan (Clinica di Medicina Interna, 1, Università di Genova, San Martino - IST, IRCCS Az. Osp. Univ., Genova), Ricchio, Roberto, Fimognari Filippo Luca (UOC Geriatria, Azienda Ospedaliera di Cosenza, Alletto, Maurizio, Messina Simona (Unità Operativa di Medicina, Elia, Ospedale S., Caltanissetta), Sesti, Giorgio, Arturi, Franco, Grembiale Alessandro (Università degli Studi, UOC Medicina Interna, Policlinico Universitario 'Mater Domini'), Scarpino Paola Elisa, Carullo Giuseppe (Cattedra di Medicina Interna, UO Malattie Cardiovascolari, Campus Universitario di Germaneto, Università Magna Graecia di Catanzaro), Frugiuele, Pierluigi, Spagnuolo Vitaliano (UOC Medicina Interna, e Reumatologia, Stabilimento Ospedaliero Annunziata, Azienda Ospedaliera Cosenza), Battaglia Giuseppe (UO Lungodegenza, Serra San Bruno, S. O., ASP Vibo Valentia), Vidili, Gianpaolo, Atzori, Sebastiana, Delitala Giuseppe (Clinica Medica, Dipartimento di Medicina Clinica, e Sperimentale, Aou, Sassari), Davì, Giovanni, Angelucci, Ermanno, Sestili Simona (UOC di Clinica Medica, PO Clinicizzato di Chieti), Traisci, Giancarlo, De Feudis Lucrezia (UOC Medicina Interna, 2, PO di Pescara), Di Michele Dario, Fava Alessandra (UOC Medicina Interna, Asl, Teramo), Balsano, Clara, De Ciantis Pierpaolo (Dipartimento di Medicina Interna, e Sanità Pubblica, Università, dell'Aquila), Desideri, Giovambattista, Camerota Antonio (UOC Geriatria, e Lungodegenza Geriatrica, Dipartimento Medico ORM, Avezzano), Po, Migliacci, Rino, Medicina Interna, Porciello Giovanni (S. C., Ospedale della Valdichiana, Cortona, Usl, 8 Arezzo), Mezzetti Matteo (UOC Medicina Interna Ospedale del Casentino-Direttore Dr. Emilio Santoro, AUSL8 Arezzo), Gresele, Paolo, Vedovati, Cristina, Fierro Tiziana (Dipartimento di Medicina Interna, Sezione di Medicina Interna, e Cardiovascolare, Università di Perugia), Puccetti, Luca, Scarpini Francesca (Centro Aterosclerosi, Trombosi, e Coagulopatie, Università degli Studi di Siena, Azienda Ospedaliero-Universitaria Senese), Bertolotti, Marco, Mussi Chiara (UO Geriatria, Università degli Studi di Modena e Reggio Emilia), Dipartimento Integrato di Medicina Endocrinologia Metabolismo e Geriatria., Boddi, Maria, Savino, Andrea, Contri Silvia (Dipartimento di Area Critica Medico- Chirurgica, Università degli Studi di Firenze), Saller, Alois, Fabris Fabrizio (Clinica Medica1, Medicina Interna CLOPD, Departement of Medicine DIMED, University of Padova, Italy), Pesavento, Raffaele, Filippi, Lucia, Vedovetto Valentina (Dipartimento di Scienze Cardiologiche, Toraciche, e Vascolari, Clinica Medica, 2, Azienda Ospedaliera-Università di Padova), Puato Massimo (Clinica Medica IV, Dipartimento di Medicina, Azienda Ospedaliera Universitaria Padova, Padova), Fabris, Fabrizio, Treleani Martina (UOA Medicina, Policlinico, Universitario, Maselli, Monica, Corradin Maria Luisa, Giantin Valter (Clinica Geriatrica, Università di Padova), Semplicini Andrea (Medicina Interna, 1, Giovanni e Paolo, Ospedale SS., Venezia), Minuz, Pietro, Calabria, Stefano, Romano Simone (Sezione di Medicina Interna, C, Università di Verona, Aoui, Verona), Fantin, Francesco, Manica Angela (Dipartimento di Medicina, Sezione di Geriatria, Stockner, Ingrid, Pattis, Peter, Wiedermann), Gutmann Bernhard (Divisione di Medicina Interna-Direttore Prof. J., Ospedale centrale di Bolzano), Catena, Cristiana, Colussi GianLuca (Hypertension Unit and Division of Internal Medicine, Department of Experimental and Clinical Medical Science, University of Udine, Udine, Italy), Annoni, Giorgio, Bruni Adriana Antonella, Castagna Alberto (Clinica Geriatrica, Università degli Studi di Milano- Bicocca, Dipartimento di Scienze della Salute, AO San Gerardo, Monza), Spinelli Diana (Medicina Interna 1a, Dipartimento di Scienze Cliniche, e di Comunità, Fondazione, Irccs, Università di Milano), Corazza Gino Roberto, Miceli, Emanuela, Padula Donatella (Clinica Medica, I, Reparto, 11, IRCCS Policlinico San Matteo di Pavia, Pavia), Schinco, Giuseppina, Spreafico Sibilla (UOC Geriatria, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico), Secchi Beatrice (UOC Medicina Interna, Ospedale, Bassini, Milano), Vanoli, Massimo, Casella Gianluca (SC Medicina Interna, Azienda Ospedaliera della Provincia di Lecco, Ospedale di Merate, Lecco), Serra Maria Grazia (UOC Medicina, Panico', Azienda Ospedaliera 'Cardinale G., Lecce), Longo, Stefania, Antonaci Salvatore (UOC Medicina Interna, Azienda Ospedaliera Policlinico, Bari), Belfiore, Anna, Giuseppe Palasciano, Frualdo Mariella (Clinica Medica 'A. Murri'-Direttore Prof., Ventrella, Francesco, Iamele Luigi (Struttura Complessa di Medicina Interna, Cerignola, Asl, Foggia), Bianco Cesare (UOC Medicina Interna, Tropea), Santovito, Donato, Mezzetti, Andrea, Cipollone Francesco (Centro di Eccellenza Europeo, e di Riferimento Regionale per l'Aterosclerosi, l'Ipertensione Arteriosa, e le Dislipidemie, Università, Chieti), Nicolai, Salvatore, Salvati Filippo (UO Medicina Interna, Ospedale di Ortona, ASL 02 Abruzzo), Rini Giovan Battista, Scozzari Francesca (UOC Medicina Interna ed Ipertensione, Dipartimento Biomedico di Medicina Interna e Specialistica (Di. Bi. M. I., S), Giaccone' di Palermo), Policlinico 'P., Muiesan Maria Lorenza, Salvetti, Massimo, Bazza Abramo (Dipartimento di Scienze Cliniche, e Sperimentali, Università di Brescia, 2° Medicina Generale Spedali Civili, Brescia), Picardi, Antonio, De Vincentis Antonio (UOC Medicina Clinica, Policlinico Universitario Campus Bio-Medico, Cosio, Paolo, Terzolo Massimo (Medicina Interna, 1, Dipartimento di Scienze Cliniche, e Biologiche, AOU San Luigi Gonzaga, Università di Torino), Madaffari, Bruno, Parasporo Bruno (UO Medicina Interna, Azienda Ospedaliera Bianchi Melacrino Morelli, Reggio, Calabria), Fenoglio, Luigi, Bracco, Christian, Melchio Remo (SC Medicina Interna, Croce e Carle, AO S., Cuneo), Gentili, Tamira, Salvi Aldo (Medicina Generale, - Settore Subintensivo, Azienda, Ospedaliero-Universitaria, Ancona), Nitti, Cinzia, Falsetti Lorenzo (Medicina Generale, - Settore Ordinario, Gabrielli, Armando, Paglione Ivano (Clinica Medica, Capucci, Alessandro, Brambatti, Michela, Sparagna Armando (Clinica di Cardiologia, Ospedale, Torrette, Tirotta Daniela (UO Medicina Generale IV, Ospedale, Cervesi, Cattolica), Andreozzi, Paola, Ettorre, Evaristo, Cipriani Elisa (Area Geriatria, DAI Medicina Interna, Sapienza-Università di Roma, Rossi Fanelli Fillippo, Delfino Massimo (UOC Medicina Interna, H, Immunologia, Clinica, Nutrizione, Clinica, Endocrinologia, Glorioso, Nicola, Melis, Giada, Marras, Gianfranca, Matta Michela (Ambulatorio Ipertensione Arteriosa, e Patologie Correlate, Aou, Sassari, Sassari), Sacco Andrea (UOC Medicina Interna, PO Madonna delle Grazie, Matera), Stellitano, Elio, Scordo Anna (UO Medicina, PO 'Tiberio Evoli', Melito Porto Salvo), Russo, Franco, Caruso Assunta Antonietta (UOC Medicina Generale di Rogliano, AO di Cosenza), Porreca, Ettore, Santilli, Francesca, Tana Marco (UO Medicina Interna, e Geriatria, Ospedale Clinicizzato Colle Dell'Ara, D'Annunzio, Università G., Chieti-Pescara), Ferri, Claudio, Grassi, Davide, Di Giosia Paolo (Divisione di Medicina Interna Universitaria, - Ospedale San Salvatore, Dipartimento, Mesva, Università, Dell'Aquila, L'Aquila), Portincasa Piero (Clinica Medica 'Murri', Dipartimento di Scienze Mediche, e Oncologia Umana, Università degli Studi di Bari), Muscianisi Giuseppe (ASP Reggio Calabria, Saline Joniche), Giordani, Sara, Stanghellini Vincenzo (Dipartimento di Scienze Mediche, e Chirurgiche, Università degli Studi di Bologna), Sabbà, Carlo, Suppressa Patrizia (UOC Geriatria e Centro di assistenza, e ricerca sovraziendale per le malattie rare, Mancuso, Giuseppe, Bartone, Mosè, Calipari Daniela (UOC Medicina Interna, Presidio, Ospedaliero, ASP di Catanzaro), Arcidiacono, Giuseppe, Bellanuova Ignazio (UOC Cardiologia, e UTIC, Catania), Ferraro, Maria, Scalzo, Antonio, Marigliano Giampietro (ASP Cosenza), Cozzolino, Domenico, Lampitella, Antonio, Acri Vera (Dipartimento di Internistica Clinica, e Sperimentale, Galasso, Domenico, Mazzei, Francesca, Galasso Salvatore (RSA Madonna di Porto Gimigliano, Catanzaro), Buratti Alberto (Azienda Ospedaliera della Provincia di Pavia, UO Medicina Interna, Ospedale, Civile, Casorate, Primo, Porta, Massimo, Brizzi Maria Felice (SC Medicina Interna 1U, Azienda, Ospedaliera, Torino), Fattorini, Annalisa, Sampietro, Francesca, D’Angelo Armando (Coagulation Service and Thrombosis Research Unit, IRCCS Ospedale San Raffaele, Pala, Marco, Fabbian, Fabio, Manfredini Roberto (UOC Clinica Medica, Anna, Azienda Ospedaliera-Universitaria S., Ferrara), Moroni, Carlo, Valente, Lucia, Lopreiato Francesco (Laboratorio di Ecocardiografia-Cardiologia Preventiva, DAI Cuore, e Grossi Vasi, Parente Fernando (UOC Medicina Interna, Granata Massimo (Immunologia Clinica, A, Moia, Marco, Braham Simon (Fondazione IRCCS Ca'Granda, Ospedale Maggiore Policlinico, Rossi, Marco, Pesce Margherita (Dipartimento di Medicina Clinica, e Sperimentale, Università di Pisa), Gentile, Adelina, Catozzo Vania (UO Medicina, Ldp, Loreto, Ferranti, Edoardo, Soldini, Maurizio, Di Napoli Mariarosaria, Baciarello Giacinto (UOC Cardiologia Preventiva, e Riabilitativa, Rancan, Elena, Ageno, Walter, Guasti Luigina (Dipartimento di Medicina Clinica, e Sperimentale, Università, Dell'Insubria, Varese), Ciccaglioni, Antonio, Negri, Silvia, Polselli Marco (Centro Elettro-Stimolazione Cardiaca, Prisco Domenico (SOD Patologia Medica, Aou, Careggi, Firenze), Pignataro Francesca Serena, Pastori, Daniele, Ferro, Domenico, Loffredo, Lorenzo, Cangemi, Roberto, Perri, Ludovica, Polimeni, Licia, Catasca, Elisa, Raparelli, Valeria, Napoleone, Laura, Schillizzi, Marianna, Vicario, Tommasa, Russo, Roberta, Gentile Maria Cristina, Saliola, Mirella, Del Ben Maria, Angelico Francesco (I Clinica Medica, Sapienza-Università di, Roma)., Violi F, Daví G, Hiatt W, Lip GY, Corazza GR, Perticone F, Proietti M, Pignatelli P, Vestri AR, Basili S, ARAPACIS Study Investigators: […, Alessandri C, Serviddio G, Fascetti S, Serra P, Palange P, Greco E, Bruno G, Averna M, Giammanco A, Sposito P, De Cristofaro R, De Gennaro L, Loria P, Pellegrini E, Cominacini L, Mozzini C, Spovieri M, Spagnuolo V, Cerqua G, Cerasola G, Mulé G, Barbagallo M, Lo Sciuto S, Monteverde A, Saitta A, Lo Gullo A, Malatino L, Cilia C, Licata G, Tuttolomondo A, Conigliaro R, Pinto A, Di Raimondo D, Signorelli S, Anzaldi M, De Palma D, Galderisi M, Cudemo G, Galletti F, Fazio V, De Luca N, Meccariello A, Caputo D, De Donato MT, Iannuzi A, Bresciani A, Giunta R, Cimini C, Utili R, Durante M, Emanuele AF, Adinolfi LE, Cristiana S, Restivo L, Bellis P, Tirelli P, Sacerdoti D, Pesce P, Vanni D, Iuliano L, Palazzuoli A, Cacciafesta M, Gueli N, Capeci W, Tarquino N, Pellegrini F, Vincentelli GM, Ravallese F, Santini C, Letizia C, Petramala L, Zinnamosca L, Cilli M, Savoriti C, Falaschi P, Martocchia A, Stefanelli M, Marigliano V, Lo Iacono C, Brusco S, Bertazzoni G, El Halabieh Elias A, Paradiso M, Lizzi EM, Stefano T, Paola B, Cerci S, Ciavolella M, Di Veroli C, Malci F, De Ciocchis A, Abate D, Castellino P, Curto I, Vecchio C, Mannarino E, Pasqualini L, Fattori C, Pende A, Denegri A, Nathan A, Ricchio R, Fimognari FL, Alletto M, Messina S, Sesti G, Arturi F, Gembiale A, Scarpino PE, Carullo G, Pierluigi F, Battaglia G, Vadili G, Atzori S, Delitala G, Davì G, Angelucci E, Simona S, Giancarlo T, De Feudis L, Di Michele D, Fava A, Balsano C, De Ciantis P, Giovambattista D, Camerota A, Migliacci R, Porciello G, Mezzetti M, Gresele P, Vedovati C, Fierro T, Puccetti L, Scarpini F, Bertolotti M, Mussi C, Boddi M, Savino A, Contri S, Saller A, Fabris F, Pesavento R, Filippi L, Vedovetto V, Puato M, Treleani M, Maselli M, Corradin ML, Giantin V, Semplicini A, Minuz P, Calabria S, Romano S, Fantin F, Manica A, Stockner I, Pattis P, Guttman B, Catena C, Colussi GL, Annoni G, Bruni AA, Castagna A, Miceli E, Padula D, Schinco G, Spreafico S, Secchi B, Vanoli M, Casella G, Serra MG, Longo S, Antonaci S, Belfiore A, Frualdo M, Francesco V, Iamele L, Bianco C, Santovito D, Mezzetti A, Cipollone F, Nicolai S, Salvati F, Battista RG, Scozzari F, Muiesan ML, Salvetti M, Bazza A, Picardi A, De Vincentis A, Cosio P, Terzolo M, Fenoglio L, Bracco C, Melchio R, Gentili T, Salvi A, Nitti C, Falsetti L, Gabrielli A, Paglione I, Capucci A, Brambatti M, Sparagna A, Tirotta D, Andreozzi P, Ettorrre E, Cipriani E, Fanelli Fillippo R, Delfino M, Glorioso N, Melis G, Marras G, Matta M, Sacco A, Stellitano E, Scordo A, Russo F, Caruso Assunta A, Porreca E, Santilli F, Tana M, Ferri C, Grassi D, Di Giosia P, Portincasa P, Muscianisi G, Giordani S, Stanghellini V, Sabbà C, Supressa P, Mancuso G, Bartone M, Calipari D, Arcidiacono G, Bellanuova I, Ferraro M, Scalzo A, Marigliano G, Cozzolina D, Lampitella A, Acri V, Galasso D, Mazzei F, Galasso S, Buratti A, Porto M, Brizzi MF, Fattorini A, Sampietro F, D'Angelo A, Pala M, Fabbian F, Manfredini R, Moroni C, Valente L, Lopreiato F, Parente F, Granata M, Moia M, Braham S, Rossi M, Pesce M, Gentile A, Catozzzo V, Ferranti E, Soldini M, Di Napoli M, Baciarello G, Rancan E, Ageno W, Guasti L, Ciccaglioni A, Negri S, Polselli M, Prisco D, Pignataro FS, Pastori D, Ferro D, Loffredo L, Cangemi R, Perri L, Polimeni L, Catasca E, Raparelli V, Napoleone L, Schillizzi M, Vicario T, Russo R, Gentile MC, Saliola M, Del Ben M, Angelico F, Farcomeni A, Di Tanna G, Davi' G, Traisci G, Montebianco Abenavoli L, Grembiale A, Di Minno G, Durante ME, Pattoneri P, Boari B, Fabio G, Perego F, Bianchi Paola I, Angeli A, Colombo BM, Giannelli G, Vidili G, Torres D, Hijazl D, Gatta A, Mannucci Mannuccio P, Licata G., and …]
Subjects: Adult, Male, Risk, therapy, atrial fibrillation, cardiovascular disease, peripheral vascular disease, Aged, Atrial Fibrillation, Female, Humans, Internal Medicine, Italy, Middle Aged, Peripheral Arterial Disease, Prevalence, Registries, Societies, Medical, Ankle Brachial Index, ATRIAL FIBRILLATION, Cardiology and Cardiovascular Medicine, Medical, RISK FACTORS, cardiovascular diseases, Societies
Abstract: To the Editor: Nonvalvular atrial fibrillation (NVAF) is the most common sustained arrhythmia encountered in clinical practice and is associated with a 5-fold increased risk for stroke (1). Moreover, patients with NVAF often suffer from atherosclerotic complications such as acute myocardial infarction (AMI) (2). Peripheral artery disease (PAD) is an established marker of systemic atherosclerosis but its prevalence in NVAF is still unclear. We reasoned that inclusion of ankle-brachial index (ABI), which is an established tool for diagnosis of PAD (3), in the CHA2DS2-VASc (4) score would better define the prevalence of vascular disease. To address this issue, the Italian Society of Internal Medicine (SIMI) established an Italian registry documenting ABI in NVAF patients. The Atrial Fibrillation Registry for the ARAPACIS (Ankle-brachial Index Prevalence Assessment: Collaborative Italian Study) study is an independent research project involving all Regional Councils of SIMI. The first objective of the study was to estimate the prevalence of ABI ≤0.90 in NVAF patients. Consecutive patients with NVAF referred to internal medicine wards were eligible for the enrollment. Enrollment started in October 2010 and continued until October 30, 2012. Patients were enrolled if they were 18 years or older and had a diagnosis of NVAF, recording during the qualifying admission/consultation or in the preceding 12 months, and if it was possible to obtain the ABI measurement. Exclusion criteria included the following: acquired or congenital valvular AF, active cancer, disease with life expectancy 0.90 (93% vs. 82%; p < 0.0001). Logistic regression analysis demonstrated that ABI ≤0.90 was significantly associated with a smoking habit (odds ratio [OR]: 1.99; 95% confidence interval [CI]: 1.48 to 2.66; p < 0.0001), diabetes (OR: 1.93; 95% CI: 1.51 to 2.46; p < 0.0001), age class 65 to 74 years (OR: 2.05; 95% CI: 1.40 to 3.07; p < 0.0001), age class ≥75 years (OR: 3.12; 95% CI: 2.16 to 4.61; p < 0.0001), and history of previous transient ischemic attack/stroke (OR: 1.64; 95% CI: 1.20 to 2.24; p = 0.002). Vascular disease, as assessed by the history elements of CHA2DS2VASc score, was recorded in 17.3% of patients; inclusion of ABI ≤0.90 in the definition of vascular disease yielded a total prevalence of 33%. A higher prevalence of vascular disease was detected if ABI ≤0.90 was included in the CHA2DS2VASc score (Fig. 1). CHA2DS2VASc including ABI ≤0.90 was more associated with previous stroke (43%; OR: 1.85; 95% CI: 1.41 to 2.44; p < 0.0001) compared to CHA2DS2VASc with ABI 0.91 to 1.39 (23%; OR: 1.52; 95% CI: 1.10 to 2.11; p = 0.0117). To the best of our knowledge, there is no large-scale study that specifically examined the prevalence of ABI ≤0.90 in NVAF. In our population, 21% had ABI ≤0.90 indicating that NVAF is often associated with systemic atherosclerosis. The CHADS2 has been recently refined with the CHA2DS2-VASc score, which includes vascular disease as documented by a history of AMI, symptomatic PAD, or detection of atherosclerotic plaque in the aortic arch (4). Comparison of vascular prevalence as assessed by CHA2DS2-VASc score and/or ABI ≤0.90 is of interest to define the potentially positive impact of measuring ABI in the management of NVAF patients. Inclusion of ABI ≤0.90 in the definition of vascular disease greatly increased the prevalence of vascular disease, which increased from 17.3% (based on history alone) to 33% (based on ABI) in the entire population. If ABI ≤0.90 was encompassed in the definition of vascular disease of CHA2DS2-VASc score the prevalence of vascular disease increased in every risk class. Inclusion of ABI ≤0.90 in the CHA2DS2-VASc score allowed us to better define the risk profile of NVAF patients with an up-grading of the risk score in each CHA2DS2-VASc score category. This may have important therapeutic implications if the new score could be tested prospectively, as a higher number of NVAF patients would potentially be candidates for an anticoagulant treatment by measuring ABI. A prospective study is, therefore, necessary to validate the risk score of this new definition of vascular disease. In conclusion, this study provides the first evidence that one-fifth of NVAF patients had an ABI ≤0.90, indicating that it may represent a simple and cheap method to better define the prevalence of vascular disease in NVAF.
Published: 2013

5. Politics out of the History of Politics

Author: Sartori, Diana and Università Di Verona
Subjects: Brown, Arendt, freedom, wounded attachments, sexual difference, libertà, attaccamenti feriti, differenza sessuale
Abstract: Wendy Brown’s approach in Politics out of History is characterized by an attempt to analyze the presence of the past which can be read not only under the light of Nietzsche’s legacy, but also through a comparison with Hannah Arendt’s conception of the gap between the past and the future. Like Arendt, Brown aims to look at the present as the site of politics and freedom, even though the former conceives the break with tradition as the unavoidable starting point, while the latter assumes that that break is not fully accomplished because it was not recognized. Rather, it produces Wounded Attachments whose effect is that of limiting the possibility of left criticism. Moving from this parallel, Brown’s analysis is compared to the Italian philosophy of sexual difference, stressing their common interest in thinking freedom beyond a female identity built on a presumed common oppression., L’approccio di Wendy Brown in La politica fuori dalla storia è caratterizzato dallo sforzo di pensare il peso del passato nel presente. Questo sforzo può essere letto non solo attraverso l’esplicita eredità di Nietzsche, ma anche attraverso un confronto con Hannah Arendt e la sua concezione della lacuna tra il passato e il futuro. Come Arendt, Brown cerca di considerare il presente come il luogo dell’azione politica e della libertà, ma mentre la prima pensa la rottura con la tradizione come un punto di partenza inevitabile, la seconda ritiene che quella rottura non si sia pienamente compiuta, perché non viene riconosciuta. Perciò, essa produce attaccamenti feriti il cui effetto è quello di limitare le possibilità della critica di sinistra. Muovendo da questo parallelo Brown viene letta accanto alla filosofia della differenza sessuale italiana, per mostrare il loro comune interesse a pensare la libertà al di là di un’identità femminile basata su di una presunta comune oppressione.
Published: 2012
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6. INVENTARI DELL’ESISTENTE: IL CONFRONTO ARMSTRONG-LOWE

Author: TAMBASSI (Università di Verona), Timothy, primary
Published: 2014
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7. Il tumore al seno: informazioni utili alle donne

Author: Gruppo Cooperativo Sul Carcinoma Mammario Azienda Ospedaliera Di Verona Università Di Verona Azienda Ulss, 2. 0. and Molino, Annamaria
Published: 2002

8. Linee Guida sulla Prevenzione Diagnosi e Terapia del Carcinoma Mammario

Author: Molino, Annamaria and Cor, Gruppo Cooperativo Sul Carcinoma Mammario Azienda Ospedaliera Di Verona Università Di Verona Azienda Ulss 2. 0.
Published: 2002

9. Evaluation of methacholine dose-response curves by linear and exponential mathematical models: goodness-of-fit and validity of extrapolation

Author: Verlato, G., Cerveri, I., Villani, A., Pasquetto, M., Ferrari, M., Fanfulla, F., Zanolin, E., Rijcken, B., de Marco, R. de M. a. r. c. o. Università di Verona: R., Lo Cascio, V., Campello, C., Rossi, F., Biasin, C., Cannistrà, A., Cenci, B., Destefani, E., Girotto, M., Lampronti, G., Martini, C., Olivieri, M., Poli, A., Tardivo, S., Zanolin, M. E., Marinoni, Università di Pavia: A., Alesina, R., Basso, O., Berrayah, L., Brusotti, R., Moi, P., Zoia, M. C., Università di Torino, Bucca, Caterina, Romano, Canzio, Aime, M., Cerutti, A., Chiampo, F., Gallo, W., Rolla, Giovanni, Sulotto, F., Casali, USSL 77 Pavia: L., Frati, C., Karytinos, P., Bugiani, USSL 7 Torino: M., Arossa, W., Caria, E., Carosso, A., Castiglioni, G., and Piccioni, P.
Subjects: methacholine challenge, dose-response curve
Published: 1996

10. Failure to Adjuvant Therapy After Pancreatic Resection for Pancreatic Cancer (FOUNTAIN)

Author: Salvatore Paiella, MD, Salvatore Paiella, MD, Università di Verona
Published: 2024

11. In situ high-pressure synchrotron X-ray diffraction study of the structural stability in NdVO{sub 4} and LaVO{sub 4}

Author: Bettinelli, M. [Luminiscent Materials Laboratory, DB and INSTM, Università di Verona, Strada Le Grazie 15, I-37134 Verona (Italy)]
Published: 2014
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12. Scuola, famiglia e bisogni di riconoscimento. Una sfida etica

Author: D'Addelfio, MULE' P., DE LUCA C., NOTTI A.M., Addi-Raccah Audrey, Università di Tel Aviv, Alessandrini Giuditta, Università di Roma Tre, Annino Alessio, Università degli Studi di Catania, Argentino Antonio, Università della Calabria, Bellingreri Antonio, Università di Palermo, Bonetta Gaetano, Università degli Studi di Catania, Calenda Marika, Università della Basilicata, Caligiuri Mario, Università della Calabria, Costa Massimiliano, Università Cà Foscari Venezia, D’Addelfio Giuseppina, Università di Palermo, Dusi Paola, Università di Verona Elia Giuseppe, Università di Bari, Ellerani Piergiuseppe, Università del Salento, Gulisano Daniela, Università degli Studi di Catania, Marzano Antonio, Università di Salerno, Marzullo Rossella, Università 'Mediterranea' di Reggio Calabria, Milito Domenico, Università della Basilicata Moretti Giovanni, Università di Roma Tre, Mulè Paolina, Università degli Studi di Catania, Notti Achille Maria, Università di Salerno, Pati Luigi, Università Cattolica Sacro Cuore di Milano, Perfetti Simona, Università della Calabria Perla Loredana, Università di Bari, Pezzano Teodora, Università della Calabria, Rossi Rossana, Università della Calabria, Sammarro Maria, Università Mediterranea di Reggio Calabria, Spadafora Giuseppe, Università della Calabria, Tammaro Rosanna, Università di Salerno, Tempesta Marcello, Università del Salento, Zini Paola, Università Cattolica Sacro Cuore di Milano., and D'Addelfio Giuseppina
Subjects: School, Families, Parent Training, Mutual Recognition
Abstract: The essay aims at highlighting the educational co-responsibility between school and family as mutual recognition path. The theoretical reference of the reflection are the writings of the philosopher P. Ricoeur on this issue. More precisely, the paper intends first to clarify the meaning of the phrase "recognition needs", taking childhood experience as a model of human experience in general; then, to show how recognition needs of the child call for corresponding responsibilities educational. Therefore, the contemporary difficulties in relations between school and family can be seen in light of incapacity of parents to take specific care of one of the two needs of recognition of their children and of living in light of this their responsibility - and therefore co-responsibility - educational. Finally, the essay asks if these parents really are themselves bearers of recognition needs, often not recognized. In this perspective, the school can be reconsidered as an educational place with specifications characteristics and potential, not only for the sake of students, but also of their parents and the whole community.
Published: 2019

13. Le rôle de l'épigraphie dans les livres des Antichi eroi et huomini illustri de Pirro Ligorio (1512 c.-1583)

Author: Vagenheim, Ginette, Équipe de Recherche Interdisciplinaire sur les Aires Culturelles (ERIAC), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut de Recherche Interdisciplinaire Homme et Société (IRIHS), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Alfredo Buonopane (Università di Verona), Lorenzo Calvelli (Università Ca' Foscari Venezia), Giovannella Cresci (Università Ca' Foscari Venezia), and Vagenheim, Ginette
Subjects: Pirro Ligorio, [SHS.ARCHEO] Humanities and Social Sciences/Archaeology and Prehistory, Falsification épigraphique, [SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, [SHS] Humanities and Social Sciences, ComputingMilieux_MISCELLANEOUS, [SHS]Humanities and Social Sciences
Abstract: International audience
Published: 2018

14. Human OX40 tunes the function of regulatory T cells in tumor and nontumor areas of hepatitis C virus-infected liver tissue

Author: Gianluca Mennini, Silvia Piconese, Massimo Sanchez, G. Grazi, Guido Antonelli, Vincenzo Barnaba, Massimo Rossi, Ilenia Pacella, Claudio Tripodo, Eleonora Timperi, Stefania Brozzetti, Simona Di Filippo, Katia Fazzi, Maria A ntonietta Lozzi, V. Schinzari, Nicola Guglielmo, Department of Internal Medicine and Medical Specialities, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Università degli studi di Palermo - University of Palermo, Dip di Chirurgia Generale e Trapianti d’Organo - Sapienza Università, Dipartimento di Chirurgia - Sapienza Università, Department of Molecular Medicine, Institut Pasteur, Fondation Cenci Bolognetti - Istituto Pasteur Italia, Fondazione Cenci Bolognetti, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], CISDEM-CSIC, Institute of Construction Science 'Eduardo Torreja', Réseau International des Instituts Pasteur (RIIP), This work was supported by the following grants obtained by V.B.: Associazione Italiana per la Ricerca sul Cancro (AIRC, progetto 'Investigator Grant' [IG]-2010/13 no. 10756), European Union grants (IMECS no. 201169, FP7-Health-2007-A, and SPHYNX no. 261365, FP7-Health-2010), Ministero della Sanità (Ricerca finalizzata [RFPS-2006-3-337923 and RFPS-2007-1-636647] and Istituto Superiore di Sanità [Progetto AIDS-2008]), Ministero dell’Istruzione,dell’Università e della Ricerca (MIUR, Programmi di ricerca di interesse nazionale [PRIN]-2008/10 no. 7245/1, [PRIN]-2011/13 no. 2010LC747T-004, AteneoSapienza [2009-C26A09PELN, 2010-C26A1029ZS, 2011-C26A11BYWP, and 2012-C26A12JL55], and Fondo per gli investimenti di ricerca di base [FIRB]-2011/13 no. RBAP10TPXK), Fondazione Cariplo (progetti no. 13535 and 3603 2010/12), FISM (Fondazione Italiana Sclerosi Multipla onlus) grant no. 2011/R/4, Fondazione Italiana per la Ricerca sull’Artrite (FIRA 2010), and Istituto Italiano di Tecnologia (IIT, A2 project 2013). This work was also supported bygrants obtained by S.P. from Associazione Italiana Ricerca sul Cancro (MFAG 8726) and from Ministero dell’Istruzione, dell’Università e della Ricerca (FIRB-Futuro in ricerca RBFR12I3UB_002)., The authors thank Marco Cassatella and Federica Calzetti (Università di Verona) for providing anti‐M‐DC8 antibody, Maria Cristina Gagliardi (Istituto Superiore di Sanità, Rome) for providing anti‐CD206 antibody, Carla Guarnotta (Università di Palermo) for technical assistance in immunohistochemical stainings, and Stefania Morrone ('Sapienza' Università di Roma, Rome) for help with cell sorting. The authors also acknowledge Massimo Locati and Alberto Mantovani for their helpful discussion., Piconese, Silvia, Timperi, Eleonora, Pacella, Ilenia, Schinzari, Valeria, Tripodo, Claudio, Rossi, Massimo, Guglielmo, Nicola, Mennini, Gianluca, Grazi, Gian Luca, Di Filippo, Simona, Brozzetti, Stefania, Fazzi, Katia, Antonelli, Guido, Lozzi, Maria Antonietta, Sanchez, Massimo, Barnaba, Vincenzo, Piconese, S, Timperi, E, Pacella, I, Schinzari, V, Tripodo, C, Rossi, M, Guglielmo, N, Mennini, G, Grazi, GL, Di Filippo, S, Brozzetti, S, Fazzi, K, Antonelli, G, Lozzi, MA, Sanchez, M, and Barnaba, V.
Subjects: MESH: Receptors, OX40/metabolism, MESH: Interleukin-12/metabolism, Liver Cirrhosis, Male, Macrophage, medicine.disease_cause, MESH: Carcinoma, Hepatocellular/immunology, T-Lymphocytes, Regulatory, MESH: OX40 Ligand/metabolism, 0302 clinical medicine, MESH: Aged, 80 and over, MESH: T-Lymphocytes, Regulatory/physiology, MESH: Up-Regulation, OX40, MESH: Aged, Aged, 80 and over, 0303 health sciences, education.field_of_study, T REG, MESH: Middle Aged, Medicine (all), MESH: Liver Cirrhosis/immunology, Liver Neoplasms, hemic and immune systems, Middle Aged, MESH: Liver Neoplasms/immunology, Phenotype, Hepatitis C, Interleukin-12, 3. Good health, Up-Regulation, Liver Neoplasm, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Interleukin 12, [SDV.IMM]Life Sciences [q-bio]/Immunology, Female, medicine.symptom, MESH: Hepatitis C/immunology, HEPATITIS C VIRUS, Human, medicine.medical_specialty, Carcinoma, Hepatocellular, Hepatitis C virus, Liver Cirrhosi, Population, Inflammation, chemical and pharmacologic phenomena, [SDV.CAN]Life Sciences [q-bio]/Cancer, OX40 Ligand, Biology, MESH: Phenotype, MESH: Liver Neoplasms/virology, 03 medical and health sciences, Ikaros Transcription Factor, Downregulation and upregulation, Internal medicine, medicine, Humans, MESH: Macrophages/metabolism, education, 030304 developmental biology, Aged, MESH: Humans, Hepatology, Macrophages, MESH: Carcinoma, Hepatocellular/virology, Receptors, OX40, MESH: Ikaros Transcription Factor/metabolism, MESH: Hepatitis C/complications, MESH: Male, OX40 ligand, Immunology, MESH: Liver Cirrhosis/virology, MESH: Female, 030215 immunology
Abstract: International audience; Regulatory T cells (Tregs) can be considered as a mixed population of distinct subsets, endowed with a diverse extent and quality of adaptation to microenvironmental signals. Here, we uncovered an opposite distribution of Treg expansion, phenotype, and plasticity in different microenvironments in the same organ (liver) derived from patients with chronic hepatitis C: On the one side, cirrhotic and tumor fragments were moderately and highly infiltrated by Tregs, respectively, expressing OX40 and a T-bet high IFN-c – " T-helper (Th)1-suppressing " phenotype; on the other side, noncirrhotic liver specimens contained low frequencies of Tregs that expressed low levels of OX40 and highly produced interferon-gamma (IFN-c; T-bet 1 IFN-c 1), thus becoming " Th1-like " cells. OX40-expressing and Th1-suppressing Tregs were enriched in the Helios-positive subset, carrying highly demethylated Treg cell-specific demethylated region that configures committed Tregs stably expressing forkhead box protein 3. OX40 ligand, mostly expressed by M2-like monocytes and macrophages, boosted OX40 1 Treg proliferation and antagonized the differentiation of Th1-like Tregs. However, this signal is counteracted in non-cirrhotic liver tissue (showing various levels of inflammation) by high availability of interleukin-12 and IFN-c, ultimately leading to complete, full Th1-like Treg differentiation. Conclusion: Our data demonstrate that Tregs can finely adapt, or even subvert, their classical inhibitory machinery in distinct microenvironments within the same organ. (HEPATOLOGY 2014;60:1494-1507)
Published: 2014

15. Causes and strategies of management for intercultural conflicts between nurses and clients. An hermeneutic-phenomenological study in an Italian context

Author: MANARA , DUILIO FIORENZO, Galli E, Alberti L, Nestola P, Sperlecchi S, Zannini L., Centro Studi Interculturali Università di Verona, OISE Centre for leadership and diversity University of Toronto, Manara, DUILIO FIORENZO, Galli, E, Alberti, L, Nestola, P, Sperlecchi, S, and Zannini, L.
Published: 2013

16. Crime and violence: lexis and cultural representations

Author: Ramon Marti Solano, Education et Diversité en Espaces Francophones (FRED), Institut Sciences de l'Homme et de la Société (IR SHS UNILIM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Dipartimento di Lingue e Letterature Straniere, Università di Verona, and Marti Solano, Ramon
Subjects: [SHS.LANGUE]Humanities and Social Sciences/Linguistics, [SHS.LANGUE] Humanities and Social Sciences/Linguistics, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2010

17. Le lyrisme anti-conjugal dans l’élégie néo-latine

Author: Leroux, Virginie, Reims Champagne-Ardenne, BU de, Centre de Recherche Interdisciplinaire sur les Modèles Esthétiques et Littéraires - EA 3311 (CRIMEL), Université de Reims Champagne-Ardenne (URCA)-Maison des Sciences Humaines de Champagne-Ardenne (MSH-URCA), Université de Reims Champagne-Ardenne (URCA)-Université de Reims Champagne-Ardenne (URCA), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), E.A. 4081 « Rome et ses renaissances », Université Paris Sorbonne, Università di Verona, Perrine Galand-Hallyn, Giovanni Rossi, and Hélène Casanova-Robin
Subjects: Poésie néolatine, Elégie, [SHS.CLASS] Humanities and Social Sciences/Classical studies, [SHS.CLASS]Humanities and Social Sciences/Classical studies, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2009

18. Analyzing Security Protocols Using Time-Bounded Task-PIOAs

Author: Dilsun Kaynar, Moses Liskov, Olivier Pereira, Ling Cheung, Nancy Lynch, Ran Canetti, Roberto Segala, IBM Research - T.J. Watson Center, MIT - CSAIL, Carnegie Mellon University, The College of William and Mary, UCL - FSA/ELEC - Département d'électricité, and Università di Verona
Subjects: Provable security, Correctness, Theoretical computer science, Oblivious transfer, probabilistic automata, Computer science, Distributed computing, Probabilistic logic, security, Cryptographic protocol, Computer security model, Nondeterministic algorithm, Control and Systems Engineering, Modeling and Simulation, verification, Concrete security, Electrical and Electronic Engineering, Computer Science::Cryptography and Security
Abstract: This paper presents the time-bounded task-PIOA modeling framework, an extension of the probabilistic input/output automata (PIOA) framework that can be used for modeling and verifying security protocols. Time-bounded task-PIOAs can describe probabilistic and nondeterministic behavior, as well as time-bounded computation. Together, these features support modeling of important aspects of security protocols, including secrecy requirements and limitations on the computational power of adversarial parties. They also support security protocol verification using methods that are compatible with less formal approaches used in the computational cryptography research community. We illustrate the use of our framework by outlining a proof of functional correctness and security properties for a well-known oblivious transfer protocol.
Published: 2008

19. Task-Structured Probabilistic I/O Automata

Author: Canetti, Ran, Cheung, Ling, Kaynar, Dilsun, Liskov, Moses, Lynch, Nancy, Pereira, Olivier, Segala, Roberto, WODES'06, IBM Research - T.J. Watson Center, Radboud University of Nijmegen, MIT - CSAIL, The College of William and Mary, UCL - FSA/ELEC - Département d'électricité, and Università di Verona
Published: 2006

20. Percorsi a norma e a rischio nei primi mesi di vita

Author: GENTA, MARIA LUISA, AAVV, UNIVERSITÀ DI VERONA, and Genta M.L.
Subjects: NASCITA PRETERMINE, COMUNICAZIONE MADRE-BAMBINO, PRIMA INFANZIA, SVILUPPO A RISCHIO, EMOZIONE
Published: 2006

21. Antecedenti comunicativi ed emotivi nella comparsa dell’attenzione coordinata agli oggetti

Author: BRIGHI, ANTONELLA, GENTA, MARIA LUISA, Comparini A., AAVV, UNIVERSITÀ DI VERONA, Brighi A., Genta M.L., and Comparini A.
Subjects: ATTENZIONE, RELAZIONE MADRE-BAMBINO, COMPETENZA SOCIALE PRECOCE, EMOZIONI, JOINT ATTENTION
Published: 2006

22. Time-Bounded Task-PIOAs: A Framework for Analyzing Security Protocols

Author: Roberto Segala, Olivier Pereira, Ran Canetti, Ling Cheung, Moses Liskov, Nancy Lynch, Dilsun Kaynar, IBM Research - T.J. Watson Center, UCL - FSA/ELEC - Département d'électricité, Radboud University of Nijmegen, MIT - CSAIL, The College of William and Mary, and Università di Verona
Subjects: Correctness, Theoretical computer science, Time-bounded task-PIOAs, Computer science, Lecture notes in computer science, Probabilistic input/output automata, Security protocols, Cryptography, 0102 computer and information sciences, 02 engineering and technology, 01 natural sciences, 0202 electrical engineering, electronic engineering, information engineering, Concrete security, Computer Science::Cryptography and Security, Informatics for Technical Applications, Oblivious transfer, business.industry, Probabilistic logic, 020206 networking & telecommunications, Computer security model, Cryptographic protocol, Nondeterministic algorithm, 010201 computation theory & mathematics, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, business
Abstract: We present the Time-Bounded Task-PIOA modeling framework, an extension of the Probabilistic I/O Automata (PIOA) framework that is intended to support modeling and verification of security protocols. Time-Bounded Task-PIOAs directly model probabilistic and nondeterministic behavior, partial-information adversarial scheduling, and time-bounded computation. Together, these features are adequate to support modeling of key aspects of security protocols, including secrecy requirements and limitations on the knowledge and computational power of adversarial parties. They also support security protocol verification, using methods that are compatible with informal approaches used in the computational cryptography research community. We illustrate the use of our framework by outlining a proof of functional correctness and security properties for a well-known Oblivious Transfer protocol.
Published: 2006

23. Formal and computational analysis of cryptographic protocols based on task-PIOAs

Author: Canetti, Ran, Cheung, Ling, Kaynar, Dilsun, Liskov, Moses, Lynch, Nancy, Pereira, Olivier, Segala, Roberto, 2006 Workshop on Cryptography and Related Mathematics, MIT - T.J. Watson Center, Radboud University of Nijmegen, MIT - CSAIL, The College of William and Mary, UCL - FSA/ELEC - Département d'électricité, and Università di Verona
Published: 2006

24. Real-life effectiveness and safety of baricitinib in patients with severe alopecia areata: A 24-week Italian study.

Author: Piraccini BM, Pampaloni F, Cedirian S, Quadrelli F, Bruni F, Rapparini L, Caro G, Acri MC, Ala L, Rossi A, Pellacani G, Lacarrubba F, Micali G, Dall'Oglio F, Vastarella M, Cantelli M, Nappa P, Diluvio L, Bianchi L, Gnesotto L, Sechi A, Naldi L, Tassone F, Peris K, Caldarola G, Pinto LM, Girolomoni G, Marangoni F, Bellinato F, Gisondi P, Scandagli I, Prignano F, Pimpinelli N, Tomasini C, Barruscotti S, De Simoni E, Simonetti O, Ambrogio F, Foti C, Boccaletti V, Fraghì A, Marzano AV, Mattioli MA, Rocca L, Barbareschi M, Ferrucci SM, Gallo G, Ribero S, Quaglino P, Balestri R, Ioris T, Caposiena Caro RD, Zalaudek I, Vagnozzi E, Fargnoli MC, Caponio C, Rubegni P, Cinotti E, Trovato E, Romanelli M, Dini V, Manzo Margiotta F, Feliciani C, de Felici Del Giudice MB, Atzori L, Sanna S, Lembo S, Raimondo A, Magnano M, and Starace M
Abstract: Background: Alopecia areata is an autoimmune condition characterized by rapid hair loss in the scalp, eyebrows and eyelashes, for which treatments are limited. Baricitinib, an oral inhibitor of Janus kinases 1 and 2, has been recently approved to treat alopecia areata., Materials and Methods: We conducted a retrospective study involving 23 medical centres across Italy, enrolling patients affected by severe alopecia areata (SALT >50), for more than 6 months. Clinical and trichoscopic assessment was performed at each visit and impact on quality of life, anxiety and depression were evaluated using the Skindex-16 and the Hospital Anxiety and Depression Scale (HADS), respectively., Results: A total of 118 patients were enrolled, with a mean age of 39 years and a mean SALT >95. The mean value of the SALT score decreased from an average of 96.6 (±8.23 sd) to 48 (±35.2 sd) after 24 weeks of treatment and 42.3% of patients achieved a SALT 30, 31.3% a SALT 20 and 20.3% a SALT 10 by Week 24. Trichoscopic signs showed fewer yellow dots and black dots significantly earlier than hair regrowth. Adverse events during the treatment period (mild laboratory test abnormalities) were reported in 12.7% patients. No drop-out were registered., Conclusion: Data on the effectiveness and safety of baricitinib are promising and support the use of this drug in severe forms of AA, also in the early stages. We also suggest performing trichoscopy in order to reveal early response to therapy., (© 2024 European Academy of Dermatology and Venereology.)
Published: 2024
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25. Inaccuracy definition of Bence Jones proteinuria in the EFLM Urinalysis Guideline 2023.

Author: Mussap M, Dolci A, and Graziani MS
Published: 2024
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26. Assessing a measure for Quality of Life in patients with severe Alopecia Areata: a multicentric Italian study.

Author: Caldarola G, Raimondi G, Samela T, Pinto L, Pampaloni F, Starace MVR, Diluvio L, Dall'Oglio F, Vagnozzi E, de Felici Del Giudice MB, Balestri R, Ambrogio F, Girolomoni G, Riva SF, Moro F, Atzori L, Gallo G, Ribero S, Simonetti O, Barruscotti S, Boccaletti V, Marzano AV, Bianchi L, Micali G, Piraccini BM, Fargnoli MC, Abeni D, and Peris K
Subjects: Humans, Italy, Female, Male, Adult, Middle Aged, Surveys and Questionnaires, Longitudinal Studies, Depression psychology, Anxiety psychology, Reproducibility of Results, Alopecia Areata psychology, Quality of Life, Psychometrics, Severity of Illness Index
Abstract: Objective: The prevalence of anxiety and depression in patients diagnosed with Alopecia Areata (AA) is very high and this significant burden of psychological symptoms threatens the Health-Related Quality of Life (HRQoL) of affected patients. Indeed, AA often does not produce significant physical symptoms, but it nonetheless disrupts many areas of mental health. Clinical assessment of disease severity may not reliably predict patient's HRQoL, nor may it predict the patient's perception of illness. For this reason, considerable effort has been made to apply and develop measures that consider patient's perception and assess the HRQoL of individuals affected by AA. The aim of this multicentric study was to provide the Italian version of the Skindex-16AA and to evaluate its psychometric properties in a clinical sample of consecutive patients with moderate-to-severe AA., Methods: This is a longitudinal, multicenter, observational study. Patients returned for follow-up visits at 4-, 12-, and 24-weeks. The analyses of the current work aimed to confirm the factorial structure of the Skindex-16AA. In the case of non-fit, an alternative structure for the model was proposed, using an Exploratory Graph Analysis and the Bayesian approach., Results: The sample was composed of 106 patients with AA. Alopecia Universalis was the most frequently diagnosed type of alopecia at all time points. The analyses on the Skindex-16AA revealed that a two-factor structure with eight items fit the data best (Bayesian Posterior Predictive Checking using 95% Confidence Interval for the Difference Between the Observed and the Replicated Chi-Square values = -6.246/56.395, Posterior Predictive P -value = 0.06), and reported satisfactory psychometric properties (i.e., internal consistency and convergent validity)., Conclusion: The Skindex-8AA demonstrated optimal psychometric properties (i.e., convergent and construct validity, and test-retest reliability) measured in a sample of patients with AA, that may suggest that it is an appropriate tool to measure the HRQoL in AA patients. However, further studies are needed in order to confirm and tested other psychometric features of this tool., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Caldarola, Raimondi, Samela, Pinto, Pampaloni, Starace, Diluvio, Dall'Oglio, Vagnozzi, de Felici del Giudice, Balestri, Ambrogio, Girolomoni, Riva, Moro, Atzori, Gallo, Ribero, Simonetti, Barruscotti, Boccaletti, Marzano, Bianchi, Micali, Piraccini, Fargnoli, Abeni and Peris.)
Published: 2024
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27. PbV 2 O 6 under compression: near zero-linear compressibility and pressure-induced change in vanadium coordination.

Author: Sánchez Martín J, Pellicer-Porres J, Turnbull R, Díaz-Anichtchenko D, Anzellini S, Liang A, Popescu C, Bettinelli M, Rodríguez-Hernández P, Muñoz A, and Errandonea D
Abstract: This study presents evidence that lead metavanadate, PbV 2 O 6 , is a material with zero-linear compressibility, which maintains its crystal size in one crystallographic direction even under external pressures of up to 20 GPa. The orthorhombic polymorph of PbV 2 O 6 (space group Pnma ) was studied up to 20 GPa using synchrotron powder X-ray diffraction, Raman spectroscopy, and density-functional theory simulations to investigate its structural and vibrational evolution under compression. Up to this pressure we find no evidence of any structural phase transitions by any diagnostic technique, however, a progressive transformation of the coordination polyhedron of vanadium atoms is revealed which results in the zero-linear compressibility. High-pressure Raman experiments enabled the identification and symmetry assignation of all 54 zone-centre Raman-active modes as well as the calculation of their respective pressure coefficients. Three independent high-pressure powder X-ray diffraction experiments were performed using different pressure-transmitting media (Ne, 4 : 1 methanol-ethanol mixture, and silicone oil). The results show a high anisotropic behaviour in the linear compressibility of the crystallographic axes. The PbV 2 O 6 bulk modulus of 86.1(9) GPa was determined using a third-order Birch-Murnaghan equation of state. The experimental results are supported by ab initio density-functional theory calculations, which provide vibrational patterns, unit-cell parameters, and atomic positions. These calculations also reveal that, unlike MgV 2 O 6 and ZnV 2 O 6 , the band gap of PbV 2 O 6 closes with pressure at a rate of -54 meV GPa -1 due to the contribution of the Pb 6s orbital to the top of the valence band.
Published: 2024
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28. Immune Phenotype-Genotype Associations in Primary Clear Cell Renal Cell Carcinoma and Matched Metastatic Tissue.

Author: Sobottka B, Vetter V, Banaei-Esfahani A, Nowak M, Lorch A, Sirek A, Mertz KD, Brunelli M, Berthold D, de Leval L, Kahraman A, Koelzer VH, and Moch H
Abstract: Adjuvant immunotherapy has been recently recommended for patients with metastatic clear cell renal cell carcinoma (ccRCC), but there are no tissue biomarkers to predict treatment response in ccRCC. Potential predictive biomarkers are mainly assessed in primary tumor tissue, whereas metastases (METs) remain understudied. To explore potential differences between genomic alterations and immune phenotypes in primary tumors and their matched METs, we analyzed primary tumors (PTs) of 47 ccRCC patients and their matched distant METs by comprehensive targeted parallel sequencing, whole-genome copy number variation analysis, determination of microsatellite instability, and tumor mutational burden. We quantified the spatial distribution of tumor-infiltrating CD8 + T cells and coexpression of the T-cell-exhaustion marker thymocyte selection-associated high mobility group box (TOX) by digital immunoprofiling and quantified tertiary lymphoid structures. Most METs were pathologically "cold." Inflamed, pathologically "hot" PTs were associated with decreased disease-free survival, worst for patients with high levels of CD8 + TOX + T cells. Interestingly, inflamed METs showed a relative increase in exhausted CD8 + TOX + T cells and increased accumulative size of tertiary lymphoid structures compared with PTs. Integrative analysis of molecular and immune phenotypes revealed BAP1 and CDKN2A/B deficiency to be associated with an inflamed immune phenotype. Our results highlight the distinct spatial distribution and differentiation of CD8+ T cells at metastatic sites, and the association of an inflamed microenvironment with specific genomic alterations., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Published: 2024
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29. [Survey on maintenance immunosuppressive therapy in patients undergoing solid organ transplantation: experiences from Italian transplant centers.]

Author: Bellini A, Rosa AC, Spila Alegiani S, Massari M, Masiero L, Finocchietti M, Marino C, Agabiti N, Cardillo M, Luxi N, Trifirò G, Fiaschetti P, Davoli M, Addis A, and Belleudi V
Subjects: Humans, Italy, Surveys and Questionnaires, Health Care Surveys, Drug Therapy, Combination, Immunosuppressive Agents administration & dosage, Organ Transplantation, Cyclosporine administration & dosage, Tacrolimus administration & dosage
Abstract: The post-organ transplant immunosuppressive therapy includes the administration of tacrolimus (Tac) or cyclosporine (CsA), along with antimetabolites (Antim) or mTOR inhibitors, with or without prednisone. A survey was conducted to investigate clinical experience regarding the use, efficacy, safety profile, and determinants of choice of maintenance immunosuppressive therapies. The questionnaire was sent to healthcare workers of 45 transplant centers specializing in kidney (K), liver (L), heart (H), and lung (P) transplants. Seventy-one responses were received from 15 Italian regions. The indicated first-choice therapy was Tac + Antim, except in the hepatic field where Tac monotherapy was favored. According to 44.1% of respondents, the first-choice therapy has changed over the last 15 years due to the replacement of CsA with Tac and increased use of mTOR inhibitors. Regarding the determinants of the index therapy, the choice of schemes to be applied depends mainly on international guidelines, previous experience, and internal protocols within the facility (80.3%; 54.9%; 50.7%, respectively). Compared to standard therapy, the criteria guiding the prescription of different therapies mainly involve the presence of comorbidities (K: 81.3%; L: 88.2%; H: 73.3%; P: 85.7%) and the evaluation of specific clinical parameters of the recipient. Additionally, the majority of respondents are in favor of using generic versions where available. The survey reveals dimensions not detectable by current healthcare administrative flows; such integrations provide a broader picture of the factors influencing the choice of post-transplant immunosuppressive therapeutic schemes.
Published: 2024
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30. Effects of uterine Doppler on midbrain growth and cortical development in late onset fetal growth restricted fetuses: a prospective cross-sectional study.

Author: Mappa I, Marra MC, Patelli C, Lu JLA, D'Antonio F, and Rizzo G
Subjects: Infant, Newborn, Pregnancy, Humans, Female, Prospective Studies, Pregnancy Trimester, Third, Cross-Sectional Studies, Ultrasonography, Prenatal, Fetal Growth Retardation diagnostic imaging, Ultrasonography, Doppler, Mesencephalon, Fetus, Gestational Age, Uterine Artery diagnostic imaging, Infant, Small for Gestational Age, Placenta
Abstract: Objective: To investigate midbrain growth, including corpus callusum (CC), cerebellar vermis (CV) and cortical development in late fetal growth restriction (FGR) depending on uterine artery (UtA) Pulsatility Index (PI) values., Methods: This was a prospective study including singleton fetuses with late FGR characterized by abnormal cerebral placental ratio (CPR). According to UtA PI values, the FGR fetuses were subdivided into normal ≤95th centile) and abnormal (>95th centile). Neurosonography was performed at 33-44 weeks of gestations to assess CC and CV lengths and the depth of Sylvian fissure (SF), parieto-occipital (POF) and calcarine fissures (CF). Neurosonographic variables were normalized for fetal head circumference size., Results: The study cohort included 60 fetuses with late FGR, 39 with normal UtA PI and 21 with abnormal PI values. The latter group showed significant differences in CC (median (interquartile range) normal 35.9 (28.49-45.53) vs abnormal UtA PI 25.31(19.76-35.13) mm; p < 0.0022), CV (normal 25.78 (18.19-29.35) abnormal UtA PI 17.03 (14.07-24.16)mm; p = 0.0067); SF (normal 10.58 (8.99-11.97)vs abnormal UtA PI 7.44 (6.23-8.46) mm; p < 0.0001), POF (normal 6.85 (6.35-8.14) vs abnormal UtA PI 4.82 (3.46-7.75) mm; p < = 0.0184) and CF (normal 04.157 (2.85-5.41) vs abnormal UtA PI 2.33 (2.49-4.01)); p < 0.0382)., Conclusions: Late onset FGR fetuses with abnormal UtA PI showed shorter CC and CV length and delayed cortical development compared to those with normal uterine PI. These findings support the existence of a link between abnormal brain development and changes in utero placental circulation.
Published: 2024
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31. Probing the Effect of Mutations on Light Harvesting in CP29 by Transient Absorption and First-Principles Simulations.

Author: Saraceno P, Sardar S, Caferri R, Camargo FVA, Dall'Osto L, D'Andrea C, Bassi R, Cupellini L, Cerullo G, and Mennucci B
Subjects: Kinetics, Arabidopsis chemistry, Arabidopsis genetics, Arabidopsis metabolism, Photosystem II Protein Complex, Light-Harvesting Protein Complexes chemistry, Light-Harvesting Protein Complexes metabolism, Light-Harvesting Protein Complexes genetics, Mutation, Energy Transfer
Abstract: Natural light harvesting is exceptionally efficient thanks to the local energy funnel created within light-harvesting complexes (LHCs). To understand the design principles underlying energy transport in LHCs, ultrafast spectroscopy is often complemented by mutational studies that introduce perturbations into the excitonic structure of the natural complexes. However, such studies may fall short of identifying all excitation energy transfer (EET) pathways and their changes upon mutation. Here, we show that a synergistic combination of first-principles calculations and ultrafast spectroscopy can give unprecedented insight into the EET pathways occurring within LHCs. We measured the transient absorption spectra of the minor CP29 complex of plants and of two mutants, systematically mapping the kinetic components seen in experiments to the simulated exciton dynamics. With our combined strategy, we show that EET in CP29 is surprisingly robust to the changes in the exciton states induced by mutations, explaining the versatility of plant LHCs.
Published: 2024
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32. Skin Reactions in Children with Type 1 Diabetes Associated with the Use of New Diabetes Technologies-An Observational Study from a Regional Polish Pediatric Diabetes Center.

Author: Ledwoń E, Zemła-Szten P, von dem Berge T, Nalewajko K, Passanisi S, Piona C, Dos Santos TJ, Svensson J, Korsgaard Berg A, and Chobot A
Abstract: The study aimed to estimate the prevalence of skin problems in children and adolescents with type 1 diabetes (T1D) using insulin pumps (IPs) and/or continuous glucose monitoring (CGM) in our center and analyze their association with various factors. As part of the international ISPAD JENIOUS-initiated SKIN-PEDIC project, we interviewed and examined patients who visited the regional pediatric diabetes center in Opole (Poland) for four weeks regarding the use of IP and/or CGM and the presence of skin problems. Body mass index (BMI) and glycemic parameters were obtained retrospectively from medical records. Among 115 individuals (45.2% girls, 83.5% IP users, 96.5% CGM users), old scars were the most common skin problem (IP users 53.1%; CGM users 66.4%), while ≥2 types of skin problems co-occurred (IP users 40.6%; CGM users 27.3%). Longer IP use was associated with a higher prevalence of skin problems (50% for IP < 1 year, 98.1%-IP 1-3 years, 100% for IP > 3 years; p < 0.001), pointing out extra attention with IP use > 1 year. No significant associations were found between skin problems and gender, age, BMI centile and glycemic parameters. Dermatological complications were common among children using IP and CGM in our center, highlighting the need for vigilant monitoring and early intervention to manage these skin-related issues effectively.
Published: 2024
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33. Phenotypic spectrum of myelin protein zero-related neuropathies: a large cohort study from five mutation clusters across Italy.

Author: Bertini A, Gentile L, Cavallaro T, Tozza S, Saveri P, Russo M, Massucco S, Falzone YM, Bellone E, Taioli F, Geroldi A, Occhipinti G, Ferrarini M, Cavalca E, Crivellari L, Mandich P, Balistreri F, Magri S, Taroni F, Previtali SC, Schenone A, Grandis M, Manganelli F, Fabrizi GM, Mazzeo A, Pareyson D, and Pisciotta C
Abstract: Background: We aimed to investigate the clinical features of a large cohort of patients with myelin protein zero ( MPZ )-related neuropathy, focusing on the five main mutation clusters across Italy., Methods: We retrospectively gathered a minimal data set of clinical information in a series of patients with these frequent mutations recruited among Italian Charcot-Marie-Tooth (CMT) registry centres, including disease onset/severity (CMTES-CMT Examination Score), motor/sensory symptoms and use of orthotics/aids., Results: We collected data from 186 patients: 60 had the p.Ser78Leu variant ('classical' CMT1B; from Eastern Sicily), 42 the p.Pro70Ser (CMT2I; mainly from Lombardy), 38 the p.Thr124Met (CMT2J; from Veneto), 25 the p.Ser44Phe (CMT2I; from Sardinia) and 21 the p.Asp104ThrfsX13 (mild CMT1B; from Apulia) mutation. Disease severity (CMTES) was higher (p<0.001) in late-onset axonal forms (p.Thr124Met=9.2±6.6; p.Ser44Phe=7.8±5.7; p.Pro70Ser=7.6±4.8) compared with p.Ser78Leu (6.1±3.5) patients. Disease progression (ΔCMTES/year) was faster in the p.Pro70Ser cohort (0.8±1.0), followed by p.Ser44Phe (0.7±0.4), p.Thr124Met (0.4±0.5) and p.Ser78Leu (0.2±0.4) patients. Disease severity (CMTES=1.2±1.5), progression (ΔCMTES/year=0.1±0.4) and motor involvement were almost negligible in p.Asp104ThrfsX13 patients, who, however, frequently (78%, p<0.001) complained of neuropathic pain. In the other four clusters, walking difficulties were reported by 69-85% of patients, while orthotic and walking aids use ranged between 40-62% and 16-28%, respectively., Conclusions: This is the largest MPZ (and late-onset CMT2) cohort ever collected, reporting clinical features and disease progression of 186 patients from five different clusters across Italy. Our findings corroborate the importance of differentiating between 'classical' childhood-onset demyelinating, late-onset axonal and mild MPZ -related neuropathy, characterised by different pathomechanisms, in view of different therapeutic targets., Competing Interests: Competing interests: GMF acknowledges donations from Pfizer to support research activities of his Research Unit, financial support from Akcea, Kedrion, Pfizer for participation in national and international meetings and from Akcea, Alnylam and Pharnext for participation in Advisory Boards; MG acknowledges donations from Sanofi Genzyme to support research activities of her Research Unit, financial support from Alnylam and Sanofi Genzyme for participation in national and international Meetings, participation in Advisory Board of Pfizer, speaker honorarium from Sanofi Genzyme; AM acknowledges financial support from Pfizer, Alnylam and Akcea for participation in national and international meetings, participation in Advisory Board of Pfizer, Alnylam and Akcea; DP acknowledges participation in Advisory Board of Inflectis, Alnylam, Akcea, Arvinas, Augustine Tx, DTx; ST is supported by the Ministry of University and Research (MUR), National Recovery and Resilience Plan (NRRP), project MNESYS (PE0000006) - A multiscale integrated approach to the study of the nervous system in health and disease (DN. 1553 11.10.2022). AB, LG, TC, PS, MR, SM, YMF, EM, FT, AG, GO, MF, EC, LC, PM, FB, SM, FT, SCP, AS, FM, CP report no disclosure., (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
Published: 2024
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34. Assessing the impact of air pollution on human embryonic cardioids using innovative longitudinal monitoring and machine learning.

Author: Hu M, Bonalumi F, Hoang ML, Burattini M, Caputo A, Bollati V, Montanini B, Rossi S, Delmonte N, and Miragoli M
Subjects: Humans, Air Pollutants adverse effects, Air Pollution adverse effects, Risk Assessment, Time Factors, Particulate Matter adverse effects, Environmental Monitoring, Environmental Exposure adverse effects, Myocytes, Cardiac drug effects, Myocytes, Cardiac metabolism, Machine Learning
Published: 2024
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35. Interhemispheric functional connectivity: an fMRI study in callosotomized patients.

Author: Marcantoni I, Piccolantonio G, Ghoushi M, Valenti M, Reversi L, Mariotti F, Foschi N, Lattanzi S, Burattini L, Fabri M, and Polonara G
Abstract: Introduction: Functional connectivity (FC) is defined in terms of temporal correlations between physiological signals, which mainly depend upon structural (axonal) connectivity; it is commonly studied using functional magnetic resonance imaging (fMRI). Interhemispheric FC appears mostly supported by the corpus callosum (CC), although several studies investigating this aspect have not provided conclusive evidence. In this context, patients in whom the CC was resected for therapeutic reasons (split-brain patients) provide a unique opportunity for research into this issue. The present study was aimed at investigating with resting-state fMRI the interhemispheric FC in six epileptic patients who have undergone surgical resection of the CC., Methods: The analysis was performed using fMRI of the Brain Software Library; the evaluation of interhemispheric FC and the recognition of the resting-state networks (RSNs) were performed using probabilistic independent component analysis., Results: Generally, bilateral brain activation was often observed in primary sensory RSNs, while in the associative areas, such as those composing the default mode and fronto-parietal networks, the activation was often unilateral., Discussion: These results suggest that even in the absence of the CC, some interhemispheric communication is still present. This residual FC might be supported through extra-callosal pathways that are likely subcortical, making it possible for some interhemispheric integration. Further studies are needed to confirm these conclusions., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Marcantoni, Piccolantonio, Ghoushi, Valenti, Reversi, Mariotti, Foschi, Lattanzi, Burattini, Fabri and Polonara.)
Published: 2024
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36. Vascular Complications in Children and Young People with Type 1 Diabetes: A Worldwide Assessment of Diabetologists' Adherence to International Recommendations.

Author: Piona C, Chobot A, Dos Santos TJ, Giani E, Marcovecchio ML, Maffeis C, and de Beaufort C
Abstract: Introduction: This global survey evaluated the practices and adherence to international Clinical Practice Consensus Guidelines (CPCG) of physicians involved in pediatric diabetes care regarding screening, prevention and treatment of vascular complications of type 1 diabetes (T1D)., Method: A web-based survey gathering data about respondents' background, practices related to screening, prevention, and treatment of diabetic nephropathy, retinopathy, neuropathy, and macrovascular diseases and a self-assessment of physicians' knowledge based on the ISPAD CPCG 2018 were shared by ISPAD., Results: We received 175 responses from 62 countries (60% female, median age 42.3 years, 72.0% ISPAD members). Two-thirds of respondents initiated nephropathy and retinopathy screening per CPCG recommendations. Only half of them adhered to recommendations for neuropathy and macrovascular disease risk factors (RFs). Over 85% of respondents used the recommended screening method for nephropathy, retinopathy and macrovascular disease RFs, and only 59% for neuropathy. Lack of access to neuropathy and macrovascular diseases RF screening methods was reported by 22.2% and 11.8% of respondents, respectively. Adherence to recommended screening frequency varied: 92% for nephropathy, around two-thirds for neuropathy and macrovascular disease RFs, and only 17.7% for retinopathy. Most participants aligned their practices for treating T1D complications with CPCG recommendations, except for nephropathy. Significant differences in adherence to CPCG and individuals' financial contributions reflected countries' income levels. Around 50% of the respondents were very familiar with the ISPAD CPCG content., Conclusion: Our study highlights global variation in adherence to CPCG for T1D vascular complications, which is influenced by country income and healthcare disparities. It also revealed knowledge gaps among physicians on this critical topic., (© 2024 The Author(s). Published by S. Karger AG, Basel.)
Published: 2024
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37. [Mortality in an Italian factory producing tetraethyl lead].

Author: Micciolo R, Cristofolini A, Orrico D, Piffer S, Rizzello R, Terracini B, and Carra G
Subjects: Humans, Italy epidemiology, Male, Middle Aged, Adult, Lead Poisoning mortality, Occupational Exposure adverse effects, Occupational Diseases mortality
Abstract: The Società Lavorazioni Organiche Inorganiche (SLOI) in Trento (North-Eastern Italy) produced tetraethyl lead from 1941 to 1978, when it was closed following an explosion, luckily with no fatalities. Working conditions were very bad. During the 1960s, 325 acute lead intoxications were reported and over 100 workers were hospitalized for neurological conditions attributable to tetraethyl lead. At least 12 SLOI workers were hospitalized in the mental asylum (psychiatric wards).The present work describes the first formal epidemiological study ever carried out on SLOI workers. In the absence of any original SLOI employee registers, a list of 1,742 workers hired since factory startup was assembled using the files of the Italian National Social Security Agency (digitalized in 1974 and perused manually by one of the Authors for the previous period). To date, follow-up for mortality has been completed for the 580 male employees at work in 1961 or hired subsequently and who worked at SLOI for at least 12 months. Twenty-two (3.8%) were lost to follow-up. Mortality in this sub-cohort was compared with that of the population of the province of Trento, gathered since 1986 by the Institute of Statistics of the Trento Province. Excluding deaths occurring at age 90+ years, during the 1986-2016 period, deaths in the SLOI sub-cohort were 295 vs 229.0 deaths expected from age- and period-specific rates in the reference population (standardazied mortality ratio 1.29; 95%CI 1.15-1.44). In the absence of individual data, the possible contribution to the mortality excess by non-occupational risk factors cannot be estimated. Identification of causes of death is underway.
Published: 2024
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38. Use, tolerability, benefits and side effects of orthotic devices in Charcot-Marie-Tooth disease.

Author: Bertini A, Manganelli F, Fabrizi GM, Schenone A, Santoro L, Cavallaro T, Tagliapietra M, Grandis M, Previtali SC, Falzone YM, Allegri I, Padua L, Pazzaglia C, Tramacere I, Cavalca E, Saveri P, Quattrone A, Valentino P, Tozza S, Gentile L, Russo M, Mazzeo A, Vita G, Prada V, Zuccarino R, Ferraro F, Pisciotta C, and Pareyson D
Subjects: Humans, Orthotic Devices, Lower Extremity, Shoes, Patient Acuity, Charcot-Marie-Tooth Disease therapy
Abstract: Background: Shoe inserts, orthopaedic shoes, ankle-foot orthoses (AFOs) are important devices in Charcot-Marie-Tooth disease (CMT) management, but data about use, benefits and tolerance are scanty., Methods: We administered to Italian CMT Registry patients an online ad hoc questionnaire investigating use, complications and perceived benefit/tolerability/emotional distress of shoe inserts, orthopaedic shoes, AFOs and other orthoses/aids. Patients were also asked to fill in the Quebec User Evaluation of Satisfaction with assistive Technology questionnaire, rating satisfaction with currently used AFO and related services., Results: We analysed answers from 266 CMT patients. Seventy per cent of subjects were prescribed lower limb orthoses, but 19% did not used them. Overall, 39% of subjects wore shoe inserts, 18% orthopaedic shoes and 23% AFOs. Frequency of abandonment was high: 24% for shoe inserts, 28% for orthopaedic shoes and 31% for AFOs. Complications were reported by 59% of patients and were more frequently related to AFOs (69%). AFO users experienced greater emotional distress and reduced tolerability as compared with shoe inserts (p<0.001) and orthopaedic shoes (p=0.003 and p=0.045, respectively). Disease severity, degree of foot weakness, customisation and timing for customisation were determinant factors in AFOs' tolerability. Quality of professional and follow-up services were perceived issues., Conclusions: The majority of CMT patients is prescribed shoe inserts, orthopaedic shoes and/or AFOs. Although perceived benefits and tolerability are rather good, there is a high rate of complications, potentially inappropriate prescriptions and considerable emotional distress, which reduce the use of AFOs. A rational, patient-oriented and multidisciplinary approach to orthoses prescription must be encouraged., Competing Interests: Competing interests: GMF acknowledges donations from Pfizer to support research activities of his Research Unit, financial support from Akcea, Kedrion, Pfizer for participation in national and international meetings and from Akcea, Alnylam and Pharnext for participation in Advisory Boards; MG acknowledges donations from Sanofi Genzyme to support research activities of her Research Unit, financial support from Alnylam and Sanofi Genzyme for participation in national and international Meetings, participation in Advisory Board of Pfizer, speaker honorarium from Sanofi Genzyme; AM acknowledges financial support from Pfizer, Alnylam and Akcea for participation in national and international meetings, participation in Advisory Board of Pfizer, Alnylam and Akcea; GV acknowledges donations from Pfizer and PTC to support research activities and participation in Advisory Board of Pfizer, Alnylam, Akcea and Pharnext; DP acknowledges participation in Advisory Board of Inflectis, Alnylam, Akcea, Arvinas, Augustine Tx, DTx. AB, IT, GMF, AS, LS, TC, MT, SCP, MS, IA, LP, CP. DC, PS, AQ, PV, ST, LG, MR, AM, SP, GDD, CP report no disclosure., (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
Published: 2024
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39. Site-Directed Mutagenesis of the Chlorophyll-Binding Sites Modulates Excited-State Lifetime and Chlorophyll-Xanthophyll Energy Transfer in the Monomeric Light-Harvesting Complex CP29.

Author: Sardar S, Caferri R, Camargo FVA, Capaldi S, Ghezzi A, Dall'Osto L, D'Andrea C, Cerullo G, and Bassi R
Subjects: Light-Harvesting Protein Complexes chemistry, Photosystem II Protein Complex metabolism, Energy Transfer, Xanthophylls, Binding Sites, Mutagenesis, Site-Directed, Chlorophyll chemistry, Lutein
Abstract: We combine site-directed mutagenesis with picosecond time-resolved fluorescence and femtosecond transient absorption (TA) spectroscopies to identify excitation energy transfer (EET) processes between chlorophylls (Chls) and xanthophylls (Xant) in the minor antenna complex CP29 assembled inside nanodiscs, which result in quenching. When compared to WT CP29, a longer lifetime was observed in the A 2 mutant, missing Chl a612, which closely interacts with Xant Lutein in site L1. Conversely, a shorter lifetime was obtained in the A 5 mutant, in which the interaction between Chl a603 and Chl a609 is strengthened, shifting absorption to lower energy and enhancing Chl-Xant EET. Global analysis of TA data indicated that EET from Chl a Q y to a Car dark state S* is active in both the A 2 and A 5 mutants and that their rate constants are modulated by mutations. Our study provides experimental evidence that multiple Chl-Xant interactions are involved in the quenching activity of CP29.
Published: 2024
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40. Photoautotrophic cultivation of a Chlamydomonas reinhardtii mutant with zeaxanthin as the sole xanthophyll.

Author: Kim M, Cazzaniga S, Jang J, Pivato M, Kim G, Ballottari M, and Jin E
Abstract: Background: Photosynthetic microalgae are known for their sustainable and eco-friendly potential to convert carbon dioxide into valuable products. Nevertheless, the challenge of self-shading due to high cell density has been identified as a drawback, hampering productivity in sustainable photoautotrophic mass cultivation. To address this issue, mutants with altered pigment composition have been proposed to allow a more efficient light diffusion but further study on the role of the different pigments is still needed to correctly engineer this process., Results: We here investigated the Chlamydomonas reinhardtii Δzl mutant with zeaxanthin as the sole xanthophyll. The Δzl mutant displayed altered pigment composition, characterized by lower chlorophyll content, higher chlorophyll a/b ratio, and lower chlorophyll/carotenoid ratio compared to the wild type (Wt). The Δzl mutant also exhibited a significant decrease in the light-harvesting complex II/Photosystem II ratio (LHCII/PSII) and the absence of trimeric LHCIIs. This significantly affects the organization and stability of PSII supercomplexes. Consequently, the estimated functional antenna size of PSII in the Δzl mutant was approximately 60% smaller compared to that of Wt, and reduced PSII activity was evident in this mutant. Notably, the Δzl mutant showed impaired non-photochemical quenching. However, the Δzl mutant compensated by exhibiting enhanced cyclic electron flow compared to Wt, seemingly offsetting the impaired PSII functionality. Consequently, the Δzl mutant achieved significantly higher cell densities than Wt under high-light conditions., Conclusions: Our findings highlight significant changes in pigment content and pigment-protein complexes in the Δzl mutant compared to Wt, resulting in an advantage for high-density photoautotrophic cultivation. This advantage is attributed to the decreased chlorophyll content of the Δzl mutant, allowing better light penetration. In addition, the accumulated zeaxanthin in the mutant could serve as an antioxidant, offering protection against reactive oxygen species generated by chlorophylls., (© 2024. The Author(s).)
Published: 2024
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41. Reduced incretin effect precedes diabetes development following duodenopancreatectomy in individuals without diabetes.

Author: Di Giuseppe G, Soldovieri L, Ciccarelli G, Ferraro PM, Quero G, Cinti F, Capece U, Moffa S, Nista EC, Gasbarrini A, Mari A, Alfieri S, Tondolo V, Pontecorvi A, Holst JJ, Giaccari A, and Mezza T
Subjects: Humans, Pancreaticoduodenectomy, Insulin, Glucagon, Blood Glucose, Incretins, Diabetes Mellitus, Type 2
Published: 2024
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42. [Communication of the diagnosis of dementia: legal aspects and (also) emerging ethical problems.]

Author: Cembrani F and De Leo D
Subjects: Humans, Communication, Dementia diagnosis
Abstract: In this paper, in a broad perspective, the problematic issues posed in clinical practice by the communication of the diagnosis of dementia are addressed. After discussing the legal determinants of the right of every person to know the truth, it was explored the ethical questions posed by the communication of unfavourable news highlighting that the scientific discussion has mainly focused on the communication of the diagnosis of neoplastic pathology. Then focus on the Spikes system adapted to the dementia of which the merits and defects are discussed before suggesting its expansion with the necessary adaptations.
Published: 2024
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43. PsoBioVax: A multicentric Italian case-control study of the immunological response to anti-SARS-CoV-2 vaccine among psoriatic patients under biological therapy.

Author: Sacchelli L, Filippi F, Balato A, Balestri R, Bellinato F, Bernardini N, Bianchi L, Burlando M, Campanati A, Chessa MA, Corazza M, Di Cesare A, Di Lernia V, Diotallevi F, Esposito M, Fargnoli MC, Gisondi P, Giunta A, Hansel K, Magnano M, Megna M, Odorici G, Prignano F, Potenza C, Rech G, Rovesti M, Ruggiero A, Satolli F, Stingeni L, Gibertoni D, and Bardazzi F
Subjects: Humans, Case-Control Studies, Biological Therapy, Italy, COVID-19 Vaccines therapeutic use, COVID-19 prevention & control
Published: 2024
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44. Driving Hebbian plasticity over ventral premotor-motor projections transiently enhances motor resonance.

Author: Chiappini E, Turrini S, Zanon M, Marangon M, Borgomaneri S, and Avenanti A
Subjects: Humans, Male, Female, Adult, Young Adult, Muscle, Skeletal physiology, Pyramidal Tracts physiology, Electromyography, Neural Pathways physiology, Motor Cortex physiology, Transcranial Magnetic Stimulation, Neuronal Plasticity physiology, Evoked Potentials, Motor physiology
Abstract: Background: Making sense of others' actions relies on the activation of an action observation network (AON), which maps visual information about observed actions onto the observer's motor system. This motor resonance process manifests in the primary motor cortex (M1) as increased corticospinal excitability finely tuned to the muscles engaged in the observed action. Motor resonance in M1 is facilitated by projections from higher-order AON regions. However, whether manipulating the strength of AON-to-M1 connectivity affects motor resonance remains unclear., Methods: We used transcranial magnetic stimulation (TMS) in 48 healthy humans. Cortico-cortical paired associative stimulation (ccPAS) was administered over M1 and the ventral premotor cortex (PMv), a key AON node, to induce spike-timing-dependent plasticity (STDP) in the pathway connecting them. Single-pulse TMS assessed motor resonance during action observation., Results: Before ccPAS, action observation increased corticospinal excitability in the muscles corresponding to the observed movements, reflecting motor resonance in M1. Notably, ccPAS aimed at strengthening projections from PMv to M1 (PMv→M1) induced short-term enhancement of motor resonance. The enhancement specifically occurred with the ccPAS configuration consistent with forward PMv→M1 projections and dissipated 20 min post-stimulation; ccPAS administered in the reverse order (M1→PMv) and sham stimulation did not affect motor resonance., Conclusions: These findings provide the first evidence that inducing STDP to strengthen PMv input to M1 neurons causally enhances muscle-specific motor resonance in M1. Our study sheds light on the plastic mechanisms that shape AON functionality and demonstrates that exogenous manipulation of AON connectivity can influence basic mirror mechanisms that underlie social perception., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Published: 2024
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45. Correction: Disentangling organizational levers and economic benefits in transitional care programs: a systematic review and configurational analysis.

Author: Landi S, Panella MM, and Leardini C
Published: 2024
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46. Ropeginterferon phase 2 randomized study in low-risk polycythemia vera: 5-year drug survival and efficacy outcomes.

Author: Barbui T, Carobbio A, De Stefano V, Alvarez-Larran A, Ghirardi A, Carioli G, Fenili F, Rossi E, Ciceri F, Bonifacio M, Iurlo A, Palandri F, Benevolo G, Pane F, Ricco A, Carli G, Caramella M, Rapezzi D, Musolino C, Siragusa S, Rumi E, Patriarca A, Cascavilla N, Mora B, Cacciola E, Calabresi L, Loscocco GG, Guglielmelli P, Gesullo F, Betti S, Ramundo F, Lunghi F, Scaffidi L, Bucelli C, Cattaneo D, Vianelli N, Bellini M, Finazzi MC, Tognoni G, Rambaldi A, and Vannucchi AM
Subjects: Humans, Hematocrit, Risk Factors, Phlebotomy, Bloodletting, Polycythemia Vera drug therapy, Polycythemia Vera diagnosis
Abstract: In patients with low-risk polycythemia vera, exposure to low-dose Ropeginterferon alfa-2b (Ropeg) 100 µg every 2 weeks for 2 years was more effective than the standard treatment of therapeutic phlebotomy in maintaining target hematocrit (HCT) (< 45%) with a reduction in the need for phlebotomy without disease progression. In the present paper, we analyzed drug survival, defined as a surrogate measure of the efficacy, safety, adherence, and tolerability of Ropeg in patients followed up to 5 years. During the first 2 years, Ropeg and phlebotomy-only (Phl-O) were discontinued in 33% and 70% of patients, respectively, for lack of response (12 in the Ropeg arm vs. 34 in the Phl-O arm) or adverse events (6 vs. 0) and withdrawal of consent in (3 vs. 10). Thirty-six Ropeg responders continued the drug for up to 3 years, and the probability of drug survival after a median of 3.15 years was 59%. Notably, the primary composite endpoint was maintained in 97%, 94%, and 94% of patients still on drug at 3, 4, and 5 years, respectively, and 60% of cases were phlebotomy-free. Twenty-three of 63 Phl-O patients (37%) failed the primary endpoint and were crossed over to Ropeg; among the risk factors for this failure, the need for more than three bloodletting procedures in the first 6 months emerged as the most important determinant. In conclusion, to improve the effectiveness of Ropeg, we suggest increasing the dose and using it earlier driven by high phlebotomy need in the first 6 months post-diagnosis., (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Published: 2024
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47. The role of computational methods in cardiovascular medicine: a narrative review.

Author: Fumagalli I, Pagani S, Vergara C, Dede' L, Adebo DA, Del Greco M, Frontera A, Luciani GB, Pontone G, Scrofani R, and Quarteroni A
Abstract: Background and Objective: Computational models of the cardiovascular system allow for a detailed and quantitative investigation of both physiological and pathological conditions, thanks to their ability to combine clinical-possibly patient-specific-data with physical knowledge of the processes underlying the heart function. These models have been increasingly employed in clinical practice to understand pathological mechanisms and their progression, design medical devices, support clinicians in improving therapies. Hinging upon a long-year experience in cardiovascular modeling, we have recently constructed a computational multi-physics and multi-scale integrated model of the heart for the investigation of its physiological function, the analysis of pathological conditions, and to support clinicians in both diagnosis and treatment planning. This narrative review aims to systematically discuss the role that such model had in addressing specific clinical questions, and how further impact of computational models on clinical practice are envisaged., Methods: We developed computational models of the physical processes encompassed by the heart function (electrophysiology, electrical activation, force generation, mechanics, blood flow dynamics, valve dynamics, myocardial perfusion) and of their inherently strong coupling. To solve the equations of such models, we devised advanced numerical methods, implemented in a flexible and highly efficient software library. We also developed computational procedures for clinical data post-processing-like the reconstruction of the heart geometry and motion from diagnostic images-and for their integration into computational models., Key Content and Findings: Our integrated computational model of the heart function provides non-invasive measures of indicators characterizing the heart function and dysfunctions, and sheds light on its underlying processes and their coupling. Moreover, thanks to the close collaboration with several clinical partners, we addressed specific clinical questions on pathological conditions, such as arrhythmias, ventricular dyssynchrony, hypertrophic cardiomyopathy, degeneration of prosthetic valves, and the way coronavirus disease 2019 (COVID-19) infection may affect the cardiac function. In multiple cases, we were also able to provide quantitative indications for treatment., Conclusions: Computational models provide a quantitative and detailed tool to support clinicians in patient care, which can enhance the assessment of cardiac diseases, the prediction of the development of pathological conditions, and the planning of treatments and follow-up tests., Competing Interests: Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tp.amegroups.com/article/view/10.21037/tp-23-184/coif). The series “The Impact of the Progresses of Knowledge and Technologies in Pediatrics” was commissioned by the editorial office without any funding or sponsorship. The authors have no other conflicts of interest to declare., (2024 Translational Pediatrics. All rights reserved.)
Published: 2024
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48. The first host plant dataset of Curculionidae Scolytinae of the world: miscellaneous Tribes.

Author: Marchioro M, Vallotto D, Ruzzier E, Besana L, Rossini M, Ortis G, Faccoli M, and Martinez-Sañudo I
Subjects: Animals, Coleoptera, Weevils, Plants parasitology
Abstract: Tribes Coriacephilini, Corthylini, Cryphalini, Ernoporini, Trypophloeini, Xyloctonini, and Xyloterini (Coleoptera: Curculionidae; Scolytinae) include spermophagous, phloeophagous, and xylomycetophagous species. Besides direct damage caused by burrowing into host plant tissues, some species are vectors of aggressive pathogens causing plant dieback and death, with consequent economic and ecological relevance. The international trade in plants and wood products is one of the main pathways for the introduction of non-native species worldwide. In this context, data availability on host plants and their economic uses is essential in pest risk assessment and for planning effective detection and monitoring strategies against invasive species. This paper provides a complete and updated list of host plants, with economic categorization, for 2139 scolytine species., (© 2024. The Author(s).)
Published: 2024
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49. Disentangling organizational levers and economic benefits in transitional care programs: a systematic review and configurational analysis.

Author: Landi S, Panella MM, and Leardini C
Subjects: Humans, Aftercare, Quality of Life, Patient Discharge, Cost-Benefit Analysis, Transitional Care
Abstract: Background: Promoting safe and efficient transitions of care is critical to reducing readmission rates and associated costs and improving the quality of patient care. A growing body of literature suggests that transitional care (TC) programs are effective in improving quality of life and reducing unplanned readmissions for several patient groups. TC programs are highly complex and multidimensional, requiring evidence on how specific practices and system characteristics influence their effectiveness in patient care, readmission reduction and costs., Methods: Using a systematic review and a configurational approach, the study examines the role played by system characteristics (size, ownership, professional skills, technology used), the organizational components implemented, analyzing their combinations, and the potential economic impact of TC programs., Results: The more organizational components are implemented, the greater the likelihood that a TC program will be successful in reducing readmission rates. Not all components have the same effect. The results show that certain components, 'post-discharge symptom monitoring and management' and 'discharge planning', are necessary but not sufficient to achieve the outcome. The results indicate the existence of two different combinations of components that can be considered sufficient for the reduction of readmissions. Furthermore, while system characteristics are underexplored, the study shows different ways of incorporating the skill mix of professionals and their mode of coordination in TC programs. Four organizational models emerge: the health-based monocentric, the social-based monocentric, the multidisciplinary team and the mono-specialist team. The economic impact of the programs is generally positive. Despite an increase in patient management costs, there is an overall reduction in all post-intervention costs, particularly those related to readmissions., Conclusions: The results underline the importance of examining in depth the role of system characteristics and organizational factors in facilitating the creation of a successful TC program. The work gives preliminary insights into how to systematize organizational practices and different coordination modes for facilitating decision-makers' choices in TC implementation. While there is evidence that TC programs also have economic benefits, the quality of economic evaluations is relatively low and needs further study., (© 2024. The Author(s).)
Published: 2024
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50. Sentinel-node biopsy in apparent early stage ovarian cancer: final results of a prospective multicentre study (SELLY).

Author: Nero C, Bizzarri N, Di Berardino S, Sillano F, Vizzielli G, Cosentino F, Vargiu V, De Iaco P, Perrone AM, Vizza E, Chiofalo B, Uccella S, Ghezzi F, Turco LC, Corrado G, Giannarelli D, Pasciuto T, Zannoni GF, Fagotti A, and Scambia G
Subjects: Humans, Female, Sentinel Lymph Node Biopsy methods, Carcinoma, Ovarian Epithelial surgery, Prospective Studies, Neoplasm Staging, Lymph Node Excision methods, Lymph Nodes surgery, Lymph Nodes pathology, Sentinel Lymph Node pathology, Lymphadenopathy, Ovarian Neoplasms surgery, Ovarian Neoplasms pathology, Endometrial Neoplasms pathology
Abstract: Aim: To evaluate the sensitivity and specificity of sentinel-lymph-node mapping compared with the gold standard of systematic lymphadenectomy in detecting lymph node metastasis in apparent early stage ovarian cancer., Methods: Multicenter, prospective, phase II trial, conducted in seven centers from March 2018 to July 2022. Patients with presumed stage I-II epithelial ovarian cancer planned for surgical staging were eligible. Patients received injection of indocyanine green in the infundibulo-pelvic and, when feasible, utero-ovarian ligaments and sentinel lymph node biopsy followed by pelvic and para-aortic lymphadenectomy was performed. Histopathological examination of all nodes was performed including ultra-staging protocol for the sentinel lymph node., Results: 174 patients were enrolled and 169 (97.1 %) received study interventions. 99 (58.6 %) patients had successful mapping of at least one sentinel lymph node and 15 (15.1 %) of them had positive nodes. Of these, 11 of 15 (73.3 %) had a correct identification of the disease in the sentinel lymph node; 7 of 11 (63.6 %) required ultra-staging protocol to detect nodal metastasis. Four (26.7 %) patients with node-positive disease had a negative sentinel-lymph-node (sensitivity 73.3 % and specificity 100.0 %)., Conclusions: In a multicenter setting, identifying sentinel-lymph nodes in apparent early stage epithelial ovarian cancer did not reach the expected sensitivity: 1 of 4 patients might have metastatic lymphatic disease unrecognized by sentinel-lymph-node biopsy. Nevertheless, 35.0 % of node positive patients was identified only thanks to ultra-staging protocol on sentinel-lymph-nodes., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier Ltd. All rights reserved.)
Published: 2024
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