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296 results on '"Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)"'

1. Bio-inspired silica-collagen materials: applications and perspectives in the medical field

Author: Thibaud Coradin, Sascha Heinemann, Martín F. Desimone, Matériaux et Biologie (MATBIO), Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC), Deutsche Forschungsgemeinschaft [TRR79-TP-M03], University of Buenos Aires [UBACYT20020110100081], Agencia Nacional de Investigaciones Cientificas y Tecnicas [BID 1728/OC-AR PICT 1783], Argentina-France MINCYT-ECOS-Sud [A12S01], CONICET-CNRS programs, and Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Subjects: CIENCIAS MÉDICAS Y DE LA SALUD, Biocompatibility, Chemistry, Biomedical Engineering, Silica, Nanotechnology, 02 engineering and technology, Large range, [CHIM.MATE]Chemical Sciences/Material chemistry, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, Biomateriales, Biotecnología de la Salud, 0104 chemical sciences, Biomaterials, Self-healing hydrogels, Drug delivery, General Materials Science, Collagen, 0210 nano-technology, High potential
Abstract: Silica and collagen are two of the most abundant substances in the Earth's geosphere and biosphere, respectively. Yet, their close association in nature has never been clearly demonstrated despite increasing evidence for the key role of silicon in mammalians. Foreseeing the therapeutic benefits of their association within composites or hybrids, a wide diversity of bio-inspired silica–collagen materials have been prepared over nearly 15 years. These works not only generated materials with a large range of structures and properties, from soft mineralized hydrogels to hard compact xerogels, but also provided more fundamental information about the interplay between polymer self-assembly processes and inorganic condensation mechanisms. Biological in vitro and in vivo evaluations suggest their bioactivity, cyto- and biocompatibility as well as controlled drug delivery properties. Hence they can now fully integrate the family of materials with high potential for the development of innovative biomedical devices. Fil: Heinemann, Sascha. Technische Universität Dresden; Alemania Fil: Coradin, Thibaud. Centre National de la Recherche Scientifique; Francia. Universite de Paris Vi; Francia Fil: Desimone, Martín Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Published: 2020

2. Antibiotic-loaded silica nanoparticle-collagen composite hydrogels with prolonged antimicrobial activity for wound infection prevention

Author: Gisela Solange Alvarez, Thibaud Coradin, Martín F. Desimone, Xiaolin Wang, Christophe Hélary, Andrea Mathilde Mebert, Instituto de Química y Metabolismo del Fármaco [Buenos Aires] (IQUIMEFA), Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] (CONICET)-Facultad de Farmacia y Bioquímica [Buenos Aires] (FFYB), Universidad de Buenos Aires [Buenos Aires] (UBA)-Universidad de Buenos Aires [Buenos Aires] (UBA), Matériaux et Biologie (MATBIO), Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)
Subjects: CIENCIAS MÉDICAS Y DE LA SALUD, Materials science, Biomedical Engineering, Nanotechnology, Biomateriales, Biotecnología de la Salud, medicine, General Materials Science, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Fibroblast, Nanocomposite, DRUG RELEASE, Rifamycin, General Chemistry, General Medicine, [CHIM.MATE]Chemical Sciences/Material chemistry, Antimicrobial, SILICA NANOPARTICLE, COLLAGEN, 3. Good health, medicine.anatomical_structure, Self-healing hydrogels, Biophysics, Gentamicin, Antibacterial activity, Wound healing, ANTIBIOTIC, medicine.drug
Abstract: Silica–collagen type I nanocomposite hydrogels are evaluated as medicated dressings to prevent infection in chronic wounds. Two antibiotics, gentamicin and rifamycin, are encapsulated in a single step within plain silica nanoparticles. Their antimicrobial efficiency against Pseudomonas aeruginosa and Staphylococcus aureus is assessed. Gentamycin-loaded 500 nm particles can be immobilized at high silica dose in concentrated collagen hydrogels without modifying their fibrillar structure or impacting on their rheological behavior and increases their proteolytic stability. Gentamicin release from the nanocomposites is sustained over 7 days, offering an unparalleled prolonged antibacterial activity. Particle immobilization also decreases their cytotoxicity towards surface-seeded fibroblast cells. Rifamycin-loaded 100 nm particles significantly alter the collagen hydrogel structure at high silica doses. The thus-obtained nanocomposites show no antibacterial efficiency, due to strong adsorption of rifamycin on collagen fibers. The complex interplay of interactions between drugs, silica and collagen is a key factor regulating the properties of these composite hydrogels as antibiotic-delivering biological dressings and must be taken into account for future extension to other wound healing agents. Fil: Alvarez, Gisela Solange. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina Fil: Hélary, Christophe. Universite Pierre et Marie Curie; Francia. Universite de Paris VI; Francia. Centre National de la Recherche Scientifique; Francia Fil: Mebert, Andrea Mathilde. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina Fil: Wang, Xiaolin. Universite Pierre et Marie Curie; Francia. Universite de Paris VI; Francia. Centre National de la Recherche Scientifique; Francia Fil: Coradin, Thibaud. Universite Pierre et Marie Curie; Francia. Universite de Paris VI; Francia. Centre National de la Recherche Scientifique; Francia Fil: Desimone, Martín Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Published: 2020

3. Effect of the sintering method on microstructure and thermal and mechanical properties of zirconium oxophosphate ceramics Zr2O(PO4)2

Author: Gustavo Mata Osoro, Céline Barreteau, Isabelle Ranc, Gilles Wallez, Damien Bregiroux, Julie Cédelle, Matériaux Hybrides et Nanomatériaux (MHN), Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Energétique Mécanique Electromagnétisme (LEME), Université Paris Nanterre (UPN), Institut de Recherche de Chimie Paris (IRCP), Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Ministère de la Culture (MC), Université Pierre et Marie Curie - Paris 6 (UPMC), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Ministère de la Culture (MC)
Subjects: A Ceramics, Thermal shock, Materials science, Spark plasma sintering, Sintering, chemistry.chemical_element, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Thermal expansion, Oxides D Mechanical properties, Relative density, General Materials Science, Ceramic, Composite material, Zirconium, General Chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Microstructure, 0104 chemical sciences, chemistry, Thermal conductivity, visual_art, [PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], visual_art.visual_art_medium, 0210 nano-technology
Abstract: International audience; Due to an ultra-low thermal expansion, Zr2O(PO4)2 could find many applications as a thermal shock resistant material. To this end, ceramic processing is a key step in order to reach best properties. In this work, Zr2O(PO4)2 was sintered by conventional sintering and by the spark plasma sintering technique (SPS) with and without additive. Samples made by conventional sintering with ZnO as sintering aid have a maximum relative density of around 92 %. Microstructure is composed of large grains and microcracks can be observed. When doped 2 with 5 wt. % of MgO, samples can be densified by SPS up to 99.6 % of the relative density and the grain size maintained between 0.5 and 1.5 μm. Thermal conductivity and Vickers microhardness were investigated as a function of the microstructure. Best values were obtained for the ceramic doped with 5 wt.% MgO and sintered by SPS, thanks to a fine microstructure and a small amount of residual microcracks.
Published: 2017

4. Stabilization of Collagen Fibrils by Gelatin Addition: A Study of Collagen/Gelatin Dense Phases

Author: Claire Teulon, Gervaise Mosser, François Portier, Flavien Guenneau, Agnieszka Nowacka-Perrin, Marie-Claire Schanne-Klein, Matériaux et Biologie (MATBIO), Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC), Laboratoire d'Optique et Biosciences (LOB), École polytechnique (X)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Spectroscopie, Modélisation, Interfaces pour L'Environnement et la Santé (SMiLES), Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and HAL-UPMC, Gestionnaire
Subjects: collagen, [CHIM.POLY] Chemical Sciences/Polymers, food.ingredient, Materials science, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Gelatin, gelatin, Biopolymers, food, Microscopy, Electron, Transmission, Liquid crystal, Phase (matter), Lyotropic, Microscopy, Polymer chemistry, Electrochemistry, General Materials Science, liquid crystal, Spectroscopy, Polarized light microscopy, Mesophase, self-assembly, Surfaces and Interfaces, 021001 nanoscience & nanotechnology, Condensed Matter Physics, [PHYS.COND.CM-SCM] Physics [physics]/Condensed Matter [cond-mat]/Soft Condensed Matter [cond-mat.soft], Extracellular Matrix, 0104 chemical sciences, [CHIM.POLY]Chemical Sciences/Polymers, Chemical engineering, Transmission electron microscopy, 0210 nano-technology, [PHYS.COND.CM-SCM]Physics [physics]/Condensed Matter [cond-mat]/Soft Condensed Matter [cond-mat.soft], biomaterials
Abstract: International audience; Collagen and its denatured form, gelatin, are biopolymers of fundamental interest in numerous fields ranging from living tissues to biomaterials, food, and cosmetics. This study aims at characterizing mixtures of those biopolymers at high concentrations (up to 100 mg·mL–1) at which collagen has mesogenic properties. We use a structural approach combining polarization-resolved multiphoton microscopy, polarized light microscopy, magnetic resonance imaging, and transmission electron microscopy to analyze gelatin and collagen/gelatin dense phases in their sol and gel states from the macroscopic to the microscopic scale. We first report the formation of a lyotropic crystal phase of gelatin A and show that gelatin must structure itself in particles to become mesogenic. We demonstrate that mixtures of collagen and gelatin phase segregate, preserving the setting of the pure collagen mesophase at a gelatin ratio of up to 20% and generating a biphasic fractal sample at all tested ratios. Moreover, differential scanning calorimetric analysis shows that each protein separates into two populations. Both populations of gelatins are stabilized by the presence of collagen, whereas only one population of collagen molecules is stabilized by the presence of gelatin, most probably those at the interface of the fibrillated microdomains and of the gelatin phase. Although further studies are needed to fully understand the involved mechanism, these new data should have a direct impact on the bioengineering of those two biopolymers.
Published: 2017

5. Antibacterial properties of sophorolipid-modified gold surfaces against Gram positive and Gram negative pathogens

Author: Claire Valotteau, Vincent Humblot, Niki Baccile, Helen Lydon, Christopher A. Mitchell, Roger Marchant, Ibrahim M. Banat, Florence Babonneau, Claire-Marie Pradier, Spectroscopie, Modélisation, Interfaces pour L'Environnement et la Santé (SMiLES), Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC), Laboratoire de Réactivité de Surface (LRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), School of Biomedical Sciences, University of Ulster, ANR-11-IDEX-0004,SUPER,Sorbonne Universités à Paris pour l'Enseignement et la Recherche(2011), and Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Salmonella typhimurium, 0301 basic medicine, Gram-negative bacteria, Streptococcus pyogenes, Gram-positive bacteria, Sophorolipid, antibacterial surface, Microbial Sensitivity Tests, Gram-Positive Bacteria, 010402 general chemistry, medicine.disease_cause, 01 natural sciences, Microbiology, membrane- damaging activity, 03 medical and health sciences, Colloid and Surface Chemistry, Staphylococcus epidermidis, Gram-Negative Bacteria, Escherichia coli, medicine, Physical and Theoretical Chemistry, biology, self-assembled monolayers, Surfaces and Interfaces, General Medicine, Antimicrobial, biology.organism_classification, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, Anti-Bacterial Agents, 0104 chemical sciences, 030104 developmental biology, Pseudomonas aeruginosa, [PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], Gold, Glycolipids, Listeria ivanovii, Antibacterial activity, Biotechnology
Abstract: International audience; Sophorolipids are bioderived glycolipids displaying interesting antimicrobial properties. We show that they can be used to develop biocidal monolayers against Listeria ivanovii, a Gram-positive bacterium. The present work points out the dependence between the surface density and the antibacterial activity of grafted sophorolipids. It also emphasizes the broad spectrum of activity of these coatings, demonstrating their potential against both Gram-positive strains (Enteroccocus faecalis, Staphylococcus epidermidis, Streptococcus pyogenes) and Gram-negative strains (Escherichia coli, Pseudomonas aeruginosa and Salmonella typhymurium). After exposure to sophorolipids grafted onto gold, all these bacterial strains show a significant reduction in viability resulting from membrane damage as evidenced by fluorescent labelling and SEM-FEG analysis.
Published: 2017

6. Solar-Water-Splitting BiVO4 Thin-Film Photoanodes Prepared By Using a Sol-Gel Dip-Coating Technique

Author: Henri Strub, Stéphane Kressman, Samantha Hilliard, Christel Laberty-Robert, Vincent Artero, Dennis Friedrich, Matériaux Hybrides et Nanomatériaux (MHN), Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Helmholtz-Zentrum Berlin für Materialien und Energie GmbH (Helmholtz-Zentrum Berlin), Helmholtz-Zentrum Berlin, Total Energies Nouvelles, Laboratoire de Chimie et Biologie des Métaux (LCBM - UMR 5249), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])
Subjects: Materials science, Annealing (metallurgy), Inorganic chemistry, 02 engineering and technology, 010402 general chemistry, 7. Clean energy, 01 natural sciences, Dip-coating, Analytical Chemistry, law.invention, chemistry.chemical_compound, law, [CHIM]Chemical Sciences, Calcination, Physical and Theoretical Chemistry, Thin film, Thin layers, Organic Chemistry, Photoelectrochemical cell, 021001 nanoscience & nanotechnology, 0104 chemical sciences, chemistry, Chemical engineering, Bismuth vanadate, Water splitting, 0210 nano-technology
Abstract: International audience; A facile and low cost method to construct a bismuth vanadate thin film photoanode was implemented with the aim of integrating it in a tandem dual water splitting photoelectrochemical cell. Multilayer semi-transparent thin films of BiVO4 were fabricated by a sol–gel process and deposited by dip-coating onto transparent conducting oxide substrates with intermediate annealing treatment between layers and final calcination at a low temperature of 450 °C in air. The effect of the intermediate annealing temperature has a great impact on the porosity, and therefore density, of thin layers of BiVO4 when fabricated by sol–gel dip-coating methods; thus, for optimal activity, the annealing temperature should be kept at 400 °C for thinner layers and 450 °C for thicker layers. The annealing temperature has a direct effect on the size of the crystallites which determines the microstructural density and porosity. In contrast, the final calcination temperature must be 450 °C in order to achieve good electrochemical performances. Optimized BiVO4 photoanodes exhibit a photocurrent of up to 2.1 mA cm−2 with an average Faradic efficiency of 85 % for oxygen evolution in neutral pH potassium phosphate buffer at 1.23 V vs. RHE under 350 mW cm−2 light irradiation.
Published: 2017

7. Cysteine-montmorillonite composites for heavy metal cation complexation: A combined experimental and theoretical study

Author: Jean-François Lambert, Khaled El Adraa, Thomas Georgelin, Frederik Tielens, Maguy Jaber, Farouk Jaber, Chemistry, Laboratoire d'Archéologie Moléculaire et Structurale (LAMS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Réactivité de Surface (LRS), Laboratoire d'Analyse des Composés Organiques, Université Libanaise, Spectroscopie, Modélisation, Interfaces pour L'Environnement et la Santé (SMiLES), Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), and Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Subjects: General Chemical Engineering, Inorganic chemistry, Composite number, 02 engineering and technology, 010402 general chemistry, DFT, 01 natural sciences, Industrial and Manufacturing Engineering, Metal, chemistry.chemical_compound, Adsorption, [CHIM]Chemical Sciences, Environmental Chemistry, Cysteine, Heavy metal cations, Composite material, Fourier transform infrared spectroscopy, Montmorillonite, Chemistry, General Chemistry, 021001 nanoscience & nanotechnology, NMR, 0104 chemical sciences, visual_art, visual_art.visual_art_medium, Density functional theory, 0210 nano-technology, Clay minerals, Hybrid material
Abstract: International audience; Green composites based on montmorillonite (Mt) and cysteine, were prepared for heavy metal removal. A comparison between the adsorption properties of the resulting hybrid inorganic-organic materials and the pure montmorillonite was carried out for the following heavy metal cations Cd2+, Hg2+, Pb2+, Co2+ and Zn2+. It appears that the adsorption capacity is higher on the composite. Moreover, in release experiments, the heavy metal cations are more strongly retained by the hybrid material. Interactions between the hybrid clay mineral and the inorganic hosts were studied by spectroscopic methods such as solid-state NMR (Nuclear Magnetic Resonance) and FTIR (Fourier Transform Infrared). The experimental data were in agreement with the theoretical periodic DFT (Density Functional Theory) calculations where a molecular picture of the adsorption complex is proposed.
Published: 2017

8. Reduction of Ln2Ti2O7 Layered Perovskites: A Survey of the Anionic Lattice, Electronic Features, and Potentials

Author: Hiroshi Kageyama, Silviu Colis, Tanguy Pussacq, Hervé Vezin, Sébastien Saitzek, Olivier Mentré, Olivier Gardoll, Cédric Tassel, Christel Laberty Robert, Houria Kabbour, Unité de Catalyse et Chimie du Solide - UMR 8181 (UCCS), Centrale Lille Institut (CLIL)-Université d'Artois (UA)-Centrale Lille-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Lille, Institut de Physique et Chimie des Matériaux de Strasbourg (IPCMS), Université de Strasbourg (UNISTRA)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Laboratoire Avancé de Spectroscopie pour les Intéractions la Réactivité et l'Environnement - UMR 8516 (LASIRE), Centre National de la Recherche Scientifique (CNRS)-Centrale Lille Institut (CLIL)-Institut de Chimie du CNRS (INC)-Université de Lille, Kyoto University [Kyoto], Matériaux Hybrides et Nanomatériaux (MHN), Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), ANR-12-JS08-0012,ANION-CO,Anion Blended Materials Conception(2012), Université d'Artois (UA)-Centrale Lille-Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Kyoto University, ENSCL, Université de Lille, CNRS, Centrale Lille, Univ. Artois, Unité de Catalyse et de Chimie du Solide (UCCS) - UMR 8181, Laboratoire de Spectrochimie et Raman (LASIR) - UMR 8516, Unité de Catalyse et Chimie du Solide - UMR 8181 [UCCS], Institut de Physique et Chimie des Matériaux de Strasbourg [IPCMS], Laboratoire Avancé de Spectroscopie pour les Intéractions la Réactivité et l'Environnement - UMR 8516 [LASIRE], Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Centrale Lille Institut (CLIL), and Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)
Subjects: Lanthanide, Chemistry, General Chemical Engineering, Inorganic chemistry, Doping, Neutron diffraction, Analytical chemistry, 02 engineering and technology, General Chemistry, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, 0104 chemical sciences, Ion, Absorbance, Vacancy defect, Materials Chemistry, [CHIM]Chemical Sciences, Water splitting, 0210 nano-technology, Thermal analysis
Abstract: International audience; The reduction of the layered perovskites Ln2Ti2O7 (LnTO, with lanthanide Ln = La, Pr, or Nd) was studied with the aim of shifting the ultraviolet (UV) photocalytic activity for water splitting in the visible range by Ti3+ donor doping. For all phases, after reduction by CaH2, the absorbance is extended beyond the UV–visible region, giving rise to a gaplike edge in the mid-infrared at ∼0.4 eV with a dark coloration of the samples. When the precursor with Ln = La was reduced under a high-temperature H2 flow, we found a progressive nanotexturation down to 300 nm, which is responsible for a degree of Ti3+ segregation at the surface. Magnetic measurements, thermal analysis, and powder neutron diffraction reveal that the samples reduced by both routes have a similar amount of anion vacancy with δ = 0.27 (in La2Ti2O7−δ). It represents a limited topotactic reduction stage, prior to the reconstructive reduction into La5Ti3.8+5O17 observed under more severe reducing conditions. For the sample reduced by CaH2, a minor amount of hydride appears to be incorporated (∼0.02 H per FU), with Ti3+···H– bonding observed by hyperfine sublevel correlation spectroscopy electron paramagnetic resonance and density functional theory calculations. Preliminary electrocatalysis tests show a promising anodic activity for water splitting hydrogen evolution with a voltage onset as low as 0.6 V versus the reversible hydrogen electrode.
Published: 2017

9. Incorporation of vanadium into the framework of hydroxyapatites: importance of the vanadium content and pH conditions during the precipitation step

Author: Sarah Petit, Cyril Thomas, Gwenaëlle Rousse, Christel Laberty-Robert, Guylène Costentin, Jean-Marc Krafft, Yannick Millot, Thrimurthulu Gode, Stanislaw Dzwigaj, Dalil Brouri, Laboratoire de Réactivité de Surface (LRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Matériaux Hybrides et Nanomatériaux (MHN), Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Chimie du solide et de l'énergie (CSE), Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Sorbonne Université (SU), Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), and Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)
Subjects: Precipitation (chemistry), Inorganic chemistry, General Physics and Astronomy, Vanadium, chemistry.chemical_element, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, 0104 chemical sciences, symbols.namesake, chemistry, Phase (matter), symbols, [CHIM]Chemical Sciences, Dehydrogenation, Hydroxyapatites, Physical and Theoretical Chemistry, 0210 nano-technology, Raman spectroscopy, Stoichiometry, Solid solution
Abstract: International audience; Even though vanadium-modified hydroxyapatite (V-HAp) samples are very promising systems for oxidative dehydrogenation of propane, the incorporation of vanadium into the hydroxyapatite framework was reported to be limited and to lead to over-stoichiometric compounds. Here, the synthesis of a Ca10(PO4)6−x(VO4)x(OH)2 stoichiometric solid solution using a co-precipitation method is monitored in the whole composition range (0 ≤ x ≤ 6) by controlling the pH of the precipitation medium, with continuous (the first series of samples) or periodic (the second series of samples) addition of NH4OH during the precipitation step or during the maturation step, respectively. It is demonstrated that the changes in pH conditions result in materials of a substantial difference in terms of the final composition. From XRD patterns and Rietveld refinements, a solid solution V-HAp phase was found to be exclusively obtained for the first series of samples for x varying from 0 to 6. This also occurred in the second series of samples but only for x lower than 4. For 4 ≤ x ≤ 5.22, the materials were composed of a mixture of V-HAp and Ca2V2O7, whereas for a x value of 6 only Ca2V2O7 was formed. The predominance of polymeric V species in solution at a high vanadium concentration deduced from the diagram of speciation of vanadium accounts for the preferential formation of Ca2V2O7 under these particular conditions. However, provided that a higher pH value was maintained, isolated VO3(OH)2− species are predominant, which accounts for the incorporation of isolated vanadates into the hydroxyapatite framework and for the well-controlled stoichiometry with Ca/(P + V) ratios found to be close to 1.67. Such a very good accommodation of vanadium in the hydroxyapatite framework is illustrated by the characterization of the local surrounding of phosphorus and vanadium species using 31P and 51V NMR, Raman and UV-vis spectroscopies.
Published: 2017

10. Insights on hydride formation over cerium-gallium mixed oxides: A mechanistic study for efficient H2 dissociation

Author: Olivier Matz, Ginesa Blanco, Christel Gervais, Adrian Lionel Bonivardi, Sebastián E. Collins, Miguel Angel Baltanas, Julia Vecchietti, Monica Calatayud, Spectroscopie, Modélisation, Interfaces pour L'Environnement et la Santé (SMiLES), Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC), Laboratoire de Chimie de la Matière Condensée de Paris (site ENSCP) (LCMCP (site ENSCP)), Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de chimie théorique (LCT), Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), Universidad Nacional del Litoral (CAID) [PI PI 501 201101 00311], ANPCyT [PICT-2012-1280, PICT-2014-0497], CONICET [PIP-2014-086], GENCI-CINES/IDRIS [2015-x2015082131, 2016-x2016082131], French Region Ile de France - SESAME program, Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)
Subjects: HYDROGEN ACTIVATION, Alkyne hydrogenation, chemistry.chemical_element, 02 engineering and technology, 010402 general chemistry, DFT, 01 natural sciences, 7. Clean energy, Medicinal chemistry, Catalysis, Ga2O3, Ceria, Gallia, Physical and Theoretical Chemistry, CATALYSIS, Hydride, SURFACES, Otras Ciencias Químicas, Ciencias Químicas, INFRARED, [CHIM.MATE]Chemical Sciences/Material chemistry, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Cerium, chemistry, Alkane dehydrogenation, Hydrogen activation, Physical chemistry, Time-resolved infrared spectroscopy, 0210 nano-technology, CIENCIAS NATURALES Y EXACTAS, CeO2
Abstract: A four-step reaction mechanism is proposed for the H2 dissociation over pure ceria and Gallium promoted mixed oxide materials, in a combined experimental and computational investigation. Two samples of cerium-gallium mixed oxides with Ce/Ga atomic ratios equal to 90/10 and 80/20 were studied by time-resolved diffuse reflectance infrared spectroscopy under H2 (D2) flow at isothermal condition in the range of 523?623 K. X-ray photoelectron spectrometry allowed to conclude that only Ce4+ is reduced to Ce3+ (Ga3+ is not reduced), in agreement with density functional theory (DFT) results. The time evolution profiles of gallium hydride ðGaAHÞ species, hydroxyl groups (OH) and Ce3+ infrared signals were analyzed and kinetic rate parameters for each step were obtained by mathematical modeling. The values for activation energies were in agreement with those calculated by DFT, for the different elementary pathways. A small activation energy (4 kcal/mol) was found for H2 dissociation found on GaOCe sites assuming that the heterolytic cleavage of the HAH bond is the rate determining step. On pure ceria, the experimental activation energy is 23 kcal/mol, showing that the addition of Ga3+ cations boosts the splitting of H2. Interestingly, the reduction step of pure CeO2 surface domains seems to proceed via a CeH/OH pair intermediate, according to DFT calculations. Moreover, 71Ga NMR experiments indicatethe possible presence of gallia nanodomains. It is proposed that the generation of Ga OACe sites in the perimeter of such surface gallia nanodomains is responsible for the enhanced reactivity of the mixed materials. The key role of this new type of sites to improve the efficiency of relevant catalytic reactions such as selective alkyne hydrogenation and light alkane dehydrogenation is then analyzed. Fil: Vecchietti, María Julia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina Fil: Baltanas, Miguel Angel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina Fil: Gervais, Christel. Universite de Paris VI; Francia Fil: Collins, Sebastián Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina Fil: Blanco. Ginesa. Universidad de Cádiz; España Fil: Matz, Olivier. Universite de Paris VI; Francia Fil: Calatayud, Monica. Universite de Paris VI; Francia Fil: Bonivardi, Adrian Lionel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Published: 2017

11. Metal–organic frameworks meet polymer brushes: enhanced crystalline film growth induced by macromolecular primers

Author: Omar Azzaroni, Juan M. Giussi, Juan A Allegretto, Elisa Bindini, Jimena Soledad Tuninetti, Matías Rafti, Gustavo M. Segovia, Universidad Nacional de la Plata [Argentine] (UNLP), Universidad Nacional de San Martin (UNSAM), Matériaux Hybrides et Nanomatériaux (MHN), Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)
Subjects: Materials science, Metal organic frameworks, Nucleation, 02 engineering and technology, 010402 general chemistry, Polymer brush, 01 natural sciences, purl.org/becyt/ford/1 [https], Polymer chemistry, purl.org/becyt/ford/1.4 [https], Materials Chemistry, [CHIM]Chemical Sciences, General Materials Science, Thin film, chemistry.chemical_classification, Otras Ciencias Químicas, fungi, Ciencias Químicas, Química, Polymer, 021001 nanoscience & nanotechnology, METAL ORGANIC FRAMEWORKS, 0104 chemical sciences, POLYMER BRUSHES, Chemical engineering, chemistry, Polymer brushes, Metal-organic framework, 0210 nano-technology, CIENCIAS NATURALES Y EXACTAS, Macromolecule
Abstract: We used poly-(3-sulfopropylmethacrylate) brushes as macromolecular 3D primers to promote heterogeneous nucleation and growth of archetypal ZIF-8 MOF thin films. The enhancement can be understood in terms of a high preconcentration of Zn2+ ions in the polymer brush; this leads to a rapid increase of nucleation sites in the primer., Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas
Published: 2017

12. Glucosomes: Glycosylated vesicle-in-vesicle aggregates in water from pH-responsive microbial glycolipid

Author: Inge N. A. Van Bogaert, Sophie Roelants, Bernd Everaert, Wim Soetaert, Patrick Le Griel, Niki Baccile, Sylvain Prévost, Spectroscopie, Modélisation, Interfaces pour L'Environnement et la Santé (SMiLES), Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), European Synchrotron Radiation Facility (ESRF), Bio Base Europe Pilot Plant, Department of Biochemical and Microbial Technology, Universiteit Gent = Ghent University [Belgium] (UGENT), Universiteit Gent = Ghent University (UGENT), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC), and Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)
Subjects: glycolipids, SOPHOROLIPIDS, bolaforms, Bolaamphiphile, 02 engineering and technology, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, 010402 general chemistry, 01 natural sciences, Micelle, surfactants, BOGORIENSIS, Glycolipid, BIOSURFACTANTS, DRUG-DELIVERY, Lipid bilayer, vesosomes, Liposome, MICELLES, BOLAAMPHIPHILE, Full Paper, Chemistry, Vesicle, Sophorolipid, Biology and Life Sciences, MIXTURES, self-assembly, General Chemistry, SELF-ASSEMBLIES, Full Papers, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Crystallography, Membrane, [SDV.SP.PG]Life Sciences [q-bio]/Pharmaceutical sciences/Galenic pharmacology, Biophysics, COMPLEMENTARY LIPOSOMES, 0210 nano-technology, SENSITIVE LIPOSOMES
Abstract: International audience; Vesicle-in-vesicle self-assembled containers, or vesosomes, are promising alternatives to liposomes because of their possible hierarchical encapsulation and high stability. We report herein the first example of sugar-based vesicles-in-vesicles, which we baptize glucosomes. These were prepared by using a natural microbial glycolipid (branched C22 sophorolipid) extracted from the culture medium of the yeast Pseudohyphozyma bogoriensis. Glucosomes spontaneously formed in water between pH 6 and pH 4 at room temperature, without the requirement of any additive. By means of pH-resolved in situ small angle X-ray scattering, we provided direct evidence for the vesicle-formation mechanism. Statistical treatment of the vesicle radii distribution measured by cryo-tansmission electron microscopy by using a derived form of the Helfrich bending free-energy expression provided an order of magnitude for the effective bending constant (the sum of the curvature and the saddle-splay moduli) of the lipid membrane to K=(0.4±0.1) kBT. This value is in agreement with the bending constant measured for hydrocarbon-based vesicles membranes.
Published: 2017

13. Nanocomposites through the Chemistry of Single-Source Precursors: Understanding the Role of Chemistry behind the Design of Monolith-Type Nanostructured Titanium Nitride/Silicon Nitride

Author: Christel Gervais, Mirna Chaker Bechelany, Vanessa Proust, Samuel Bernard, Sylvie Malo, Philippe Miele, Abhijeet Lale, Institut Européen des membranes (IEM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de cristallographie et sciences des matériaux (CRISMAT), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche sur les Matériaux Avancés (IRMA), Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Rouen Normandie (UNIROUEN), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Spectroscopie, Modélisation, Interfaces pour L'Environnement et la Santé (SMiLES), Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), French Rhone-Alpes council (Cible project) [1897], CEFIPRA agency [5108-1], CNRS, DGA, national research group ``Matinex', French Region Ile de France-SESAME program, Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM), École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Institut de Chimie du CNRS (INC), and Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)
Subjects: Silicon, Thermogravimetric analysis, Processability, Inorganic chemistry, chemistry.chemical_element, 02 engineering and technology, Nitride, 010402 general chemistry, 01 natural sciences, Precursor chemistry, Catalysis, chemistry.chemical_compound, symbols.namesake, Titanium, Nanocomposite, Organic Chemistry, [CHIM.MATE]Chemical Sciences/Material chemistry, General Chemistry, 021001 nanoscience & nanotechnology, Titanium nitride, Nanostructures, 0104 chemical sciences, Amorphous solid, Silicon nitride, chemistry, Chemical engineering, symbols, 0210 nano-technology, Tin, Raman spectroscopy
Abstract: International audience; Monolith-type titanium nitride/silicon nitride nanocomposites, denoted as TiN/Si3N4, have been prepared by a reaction of polysilazanes with a titanium amide precursor, warm pressing of the resultant polytitanosilazanes, and subsequent pyrolysis of the green bodies at 1400 degrees C. Initially, a series of polytitanosilazanes was synthesized and the role of the chemistry behind their synthesis was studied in detail by using solid-state NMR spectroscopy, elemental analysis, and molecular-weight measurements. The intimate relationship between the chemistry and the processability of these precursors is discussed. Polytitanosilazanes display the appropriate requirements for facile processing in solution and as a melt, but they must be treated with liquid ammonia to be adapted for solid-state processing, that is, warm-pressing, to design dense and mechanically stable structures after pyrolysis. We provide a comprehensive mechanistic study of the nanocomposite conversion based on solid-state NMR spectroscopy coupled with thermogravimetric experiments. HRTEM images coupled with XRD and Raman spectroscopy confirmed the unique nanostructural features of the nanocomposites, which appear to be a result of the molecular origin of the materials. The as-obtained samples are composed of an amorphous Si3N4 matrix, in which TiN nanocrystals are homogeneously formed in situ in the matrix during the process. The hardness and Young moduli were measured and are discussed.
Published: 2016

14. L’étude de la cristallurie améliore le diagnostic et la prise en charge thérapeutique de la lithiase rénale

Author: Vincent Frochot, Paul Jungers, Dominique Bazin, Michel Daudon, Des Maladies Rénales Rares aux Maladies Fréquentes, Remodelage et Réparation, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Spectroscopie, Modélisation, Interfaces pour L'Environnement et la Santé (SMiLES), Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique des Solides (LPS), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Département de Néphrologie [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC), Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11), CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), and d'Eggis, Gilles
Subjects: Crystalluria, medicine.medical_specialty, Chemistry(all), Global crystal volume, General Chemical Engineering, 030232 urology & nephrology, Calcium oxalate, Urology, Renal function, Uric acids, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, Primary hyperoxaluria, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cristallurie, Oxalates de calcium, medicine, Hypercalciuria, 030212 general & internal medicine, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], Crystalluria index, [SDV.BBM.BC] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], Pathological, Index cristallurique, business.industry, Dihydroxyadenine, Acides uriques, General Chemistry, Cystinuria, medicine.disease, [SDV.MHEP.UN] Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, Dihydroxyadénine, 3. Good health, Volume cristallin global, chemistry, Hereditary Diseases, Chemical Engineering(all), Cystine, medicine.symptom, business, Calcium oxalates
Abstract: The search for crystalluria and morphologic analysis of urinary crystals is of interest in the diagnostic evaluation and assessment of efficacy of therapeutic strategies in stone formers. In common calcium oxalate (CaOx) nephrolithiasis, identification of the monohydrate or dihydrate form of CaOx orients toward hyperoxaluria or hypercalciuria as the main lithogenic mechanism, respectively. An unusual high abundance of crystals exclusively made of CaOx monohydrate is highly suggestive of primary hyperoxaluria, the most severe of all types of renal stone diseases. The identification of crystal species such as struvite, cystine, 2,8-dihydroxyadenine, which are not found in normal urine, is indicative of specific pathological conditions, namely, infection stones and hereditary diseases such as cystinuria and dihydroxyadeninuria. Such diseases expose to progressive loss of renal function unless they are prevented by specific therapeutic measures. The presence of crystals made of drugs may entail the risk of kidney dysfunction because of crystallization of the drug or its metabolites.Serial determination of crystalluria, which reflects the activity of stone disease and its response to therapeutic measures, is of major interest in the follow-up of patients suffering from nephrolithiasis. It should be more largely used in clinical practice in most stone formers, still more for the surveillance of patients affected by severe, hereditary renal stone diseases such as primary hyperoxaluria, cystinuria, and dihydroxyadeninuria, where determination of the global crystal volume allows assessing the efficacy of therapeutic measures and optimizing the medical management of the patients., L’étude de la cristallurie et de ses caractéristiques qualitatives et quantitatives est d'un intérêt clinique majeur pour le diagnostic de la maladie lithiasique et l’évaluation de l'efficacité des mesures thérapeutiques proposées aux patients. Dans la lithiase oxalocalcique commune, la forme cristalline, whewellite ou weddellite, oriente respectivement vers une hyperoxalurie ou une hypercalciurie. Une quantité élevée de cristaux de whewellite traduit une forte hyperoxalurie et doit faire rechercher une hyperoxalurie primaire. L'identification de cristaux particuliers tels que la struvite, la cystine, la dihydroxy-2,8-adénine permet le diagnostic de pathologies spécifiques qui exposent à une altération progressive de la fonction rénale lorsqu'elles ne sont pas traitées précocement par des mesures adaptées. La présence de cristaux médicamenteux peut expliquer l'origine d'une insuffisance rénale aiguë développée sous traitement.Au cours du suivi des patients souffrant de lithiase, la détermination de la cristallurie sur des prélèvements sériés est d'un grand intérêt pour la prévention du risque de récidive de calculscar elle reflète l'activité de la maladie lithiasique et sa réponse aux mesures diététiques et thérapeutiques. Elle peut donc bénéficier à la plupart des patients lithiasiques. Elle se doit d’être réalisée chez tout patient souffrant d'une forme héréditaire sévère de lithiase telle que cystinurie, hyperoxalurie primaire ou dihydroxyadéninurie pour en optimiser la prise en charge thérapeutique, la détermination du volume cristallin global dans ces pathologies cristallines sévères permettant d'adapter le traitement médical, d’évaluer l'efficacité des mesures thérapeutiques proposées et de modifier celles-ci en fonction des résultats obtenus.
Published: 2016

15. Randall’s plaque and kidney stones: Recent advances and future challenges

Author: Emmanuel Letavernier, Michel Daudon, Dominique Bazin, Administateur, HAL Sorbonne Université, Des Maladies Rénales Rares aux Maladies Fréquentes, Remodelage et Réparation, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'Explorations fonctionnelles multidisciplinaires [CHU Tenon], CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Spectroscopie, Modélisation, Interfaces pour L'Environnement et la Santé (SMiLES), Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC), and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)
Subjects: 0301 basic medicine, Pathology, medicine.medical_specialty, Chemistry(all), General Chemical Engineering, Calcium oxalate kidney stones, 030232 urology & nephrology, Calcium oxalate, chemistry.chemical_element, Calcium, Kidney, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, Oxalate, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Interstitial tissue, medicine, Randall’s plaque, General Chemistry, medicine.disease, [SDV.MHEP.UN] Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, 3. Good health, 030104 developmental biology, medicine.anatomical_structure, chemistry, Randall's plaque, Calcium Oxalate Crystals, Chemical Engineering(all), Kidney stones
Abstract: International audience; Alexander Randall described eight decades ago a heterogeneous nucleation process at the tip of renal papillae giving birth to calcium oxalate stones. Kidney stones were for the first time described to originate from calcium phosphate plaques growing in the interstitial tissue, breaking urothelium and then promoting calcium oxalate crystals aggregation at their contact. During the next decades, few studies were dedicated to these Randall's plaques but the increasing incidence of calcium oxalate kidney stones, the development of endoscopic procedures allowing plaques visualization and series evidencing the high proportion of calcium oxalate stones generated on these plaques renewed interest in Randall's plaque. Although some progress has been carried during the past two decades, the origin of Randall' plaques, their composition, their role in kidney stones epidemic, their specific affinity for some crystalline phases, and their potential deleterious effects in kidney tissues are among the challenges that lie ahead.
Published: 2016
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16. Type 2 diabetes and uric acid stones: A powder neutron diffraction investigation

Author: Emmanuel Letavernier, Guy Matzen, Raphaël Weil, Emmanuel Véron, Michel Daudon, Dominique Bazin, Gilles André, HAL-UPMC, Gestionnaire, Service d'Explorations fonctionnelles multidisciplinaires [CHU Tenon], CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Des Maladies Rénales Rares aux Maladies Fréquentes, Remodelage et Réparation, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de Physique des Solides (LPS), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Conditions Extrêmes et Matériaux : Haute Température et Irradiation (CEMHTI), Université d'Orléans (UO)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Léon Brillouin (LLB - UMR 12), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Spectroscopie, Modélisation, Interfaces pour L'Environnement et la Santé (SMiLES), Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université d'Orléans (UO), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Saclay, and Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)
Subjects: medicine.medical_specialty, Chemistry(all), General Chemical Engineering, Urinary system, Neutron diffraction, 030232 urology & nephrology, Urology, Uric acid stones, Type 2 diabetes, 030204 cardiovascular system & hematology, Structural difference, Nephrolithiasis, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Diabetes mellitus, medicine, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Gender, General Chemistry, medicine.disease, 3. Good health, Biochemistry, chemistry, Chemical Engineering(all), Uric acid, Kidney stones, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: International audience; Background: Recent epidemiologic investigations have identified an association between type 2 diabetes and uric acid kidney stones. This association was more apparent in women than in men. However, male patients are more prone than women to form uric acid stones in upper and lower urinary tract. In addition, uric acid stone morphology may be different according to stone location. Finally, it was shown that uric acid stone prevalence is increasing with the patient’s age. Aim of the study: To compare uric acid crystal size as determined by powder neutron diffraction with clinical data and the gender of patients. Material and methods: Uric acid stones from 43 patients (24 males, 19 females) identified by Fourier transform infrared spectroscopy were investigated using Environmental Scanning Electron Microscopy and Powder neutron diffraction.Results: Uric acid anhydrous was the main crystalline form of the stones. The mean size of the crystals was 91.3 ± 28.5 nm. No significant differences were found regarding uric acid crystal size in the stones by comparison to the stone location or the patient’s age. However, particle sizes of uric acid kidney stones were significantly different between male and female patients (84.7 ± 5.3 vs. 140.2 ± 6.7 nm, p < 0.000003) in the absence of diabetes mellitus. Interestingly, when type 2 diabetes appeared, this structural difference between male and female vanished (76.1 ± 3.9 vs. 78.8 ± 4.2 nm, not significant). Thus, the complete set of structural data is in line with observations regarding epidemiological data. Some explanations based on supersaturation are discussed.
Published: 2016
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17. Analyse des cristaux d’hydroxyapatite dans l’os sous chondral par spectroscopie infrarouge à transformée de Fourier et diffraction neutronique sur poudres

Author: Michel Daudon, Christine Chappard, Gilles André, Dominique Bazin, Bioingénierie et Bioimagerie Ostéo-articulaires, Biomécanique et Biomatériaux Ostéo-Articulaires (B2OA (UMR_7052)), École nationale vétérinaire - Alfort (ENVA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Léon Brillouin (LLB - UMR 12), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Des Maladies Rénales Rares aux Maladies Fréquentes, Remodelage et Réparation, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Spectroscopie, Modélisation, Interfaces pour L'Environnement et la Santé (SMiLES), Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), École nationale vétérinaire d'Alfort (ENVA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Saclay, and Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)
Subjects: Diffraction, Materials science, Chemistry(all), Infrared, General Chemical Engineering, Neutron diffraction, Analytical chemistry, 02 engineering and technology, macromolecular substances, 010402 general chemistry, 01 natural sciences, Corps humain, symbols.namesake, Osteoarthritis, [CHIM]Chemical Sciences, Fourier transform infrared spectroscopy, Anisotropy, Spectroscopy, Bone, Diffraction neutronique sur poudres, Anisotropie, Human tissues, technology, industry, and agriculture, Hydroxy-apatite cristals, Spectroscopie infrarouge à transformée de Fourier, General Chemistry, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Fourier transform, FTIR, symbols, Cristaux d'hydroxyapatite, Chemical Engineering(all), Ostéoarthrose, Crystallite, Powder neutron diffraction, 0210 nano-technology
Abstract: International audience; CR_Chimie_22_HAL_Chappard_8Juin2015 1 1 Analysis of hydroxyapatite crystallites in subchondral bone by Fourier transform infrared spectroscopy and powder neutron diffraction methods Analyse des cristaux d'hydroxyapatite dans l'os sous chondral par spectroscopie infra-rouge à transformée de Fourier et diffraction neutronique sur poudres ABSTRACT English Fourier Transform Infrared (FTIR) spectroscopy and powder neutron diffraction (PND) were performed in human subchondral bone covered (C+) or not covered by cartilage (C-) to study hydroxyapatite. With FTIR, the carbonation rate was 30% with identical spectra in C+ and C-. With PND, the width of the diffraction peak (hkl=002) highlighted the anisotropy of nanocrystals (with needle and/or platelet-like shape) along the c-axis with average length of 50 nm and thickness of 10 nm and with no difference between C+ and C- .; Des expérimentations par spectroscopie infrarouge à transformée de Fourier (FTIR) et par diffraction neutronique sur poudres (PND) ont été réalisées sur de l’os sous-chondral humain recouvert (C+) ou non recouvert par le cartilage (C) pour étudier l’hydroxyapatite (HAP).En FTIR, le taux de carbonatation est de 30% avec des spectres identiques pour C+ et C−. Avec la PND, la largeur du pic de diffraction (hkl = 002) a mis en évidence l'anisotropie des nanocristaux (en forme aiguille et/ou de plaquettes) le long de l'axe c, avec une longueur moyenne de 50 nm et une épaisseur de 10 nm, sans différence entre C+ et C−.
Published: 2016
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18. Vibrational spectroscopies to investigate concretions and ectopic calcifications for medical diagnosis

Author: Michel Daudon, Dominique Bazin, Des Maladies Rénales Rares aux Maladies Fréquentes, Remodelage et Réparation, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Spectroscopie, Modélisation, Interfaces pour L'Environnement et la Santé (SMiLES), Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique des Solides (LPS), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Service d'Explorations fonctionnelles multidisciplinaires [CHU Tenon], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC), Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11), HAL-UPMC, Gestionnaire, and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)
Subjects: Chemistry(all), Chemistry, Biopsy, General Chemical Engineering, 010401 analytical chemistry, Fourier transform infrared spectroscopy, 02 engineering and technology, General Chemistry, 021001 nanoscience & nanotechnology, Crystals, 01 natural sciences, Raman microspectroscopy, 0104 chemical sciences, Urinary calculi, Nuclear magnetic resonance, [CHIM] Chemical Sciences, Raman spectroscopy, Chemical Engineering(all), [CHIM]Chemical Sciences, Medical diagnosis, Infrared microspectroscopy, 0210 nano-technology, Infrared microscopy
Abstract: International audience; As asserted by numerous authors, Fourier Transform (FT)-Raman and FT-Infrared spectroscopies constitute two useful tools for bio-medical diagnostics. We can distinguish two different kinds of application, namely, tissue disorders analyzed using statistical methods, and detection of ectopic calcifications through precise analysis of the shape and the position of absorption bands. In this contribution, we present some new results regarding these research themes, as well as recent experimental developments, such as the ability to perform nanometer scale near-field infrared microscopy, which have already led to major scientific breakthroughs.
Published: 2016

19. Combination of X-ray synchrotron radiation techniques to gather information for clinicians

Author: Michel Daudon, Dominique Thiaudière, Cristian Mocuta, Solenn Reguer, Dominique Bazin, Synchrotron SOLEIL (SSOLEIL), Centre National de la Recherche Scientifique (CNRS), Service d'Explorations fonctionnelles multidisciplinaires [CHU Tenon], CHU Tenon [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Spectroscopie, Modélisation, Interfaces pour L'Environnement et la Santé (SMiLES), Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), and Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Chemistry(all), Computer science, General Chemical Engineering, Synchrotron radiation, 02 engineering and technology, Radiation, Cellular level, Nephrolithiasis, 010402 general chemistry, 01 natural sciences, X ray synchrotron, Optics, [CHIM]Chemical Sciences, Information retrieval, business.industry, X-ray absorption spectroscopy, Electronic information, General Chemistry, X-ray scattering, 021001 nanoscience & nanotechnology, osteoporosis, X-Ray Fluorescence Spectroscopy, 0104 chemical sciences, X-ray fluorescence spectroscopy, arthritis, Chemical Engineering(all), 0210 nano-technology, business
Abstract: International audience; Among the different techniques specific to synchrotron radiation, the combination of X-ray absorption spectroscopy with X-ray scattering experiments is a powerful tool to characterize samples with a capability to gather structural and electronic information at the cellular level. In the present contribution, selected examples making use of such techniques, point out as well the information that one can have access to. Via the presentation of the physicochemical data, this paper focuses on displaying the information that has a significant clinical character.
Published: 2016

20. Silica nanoparticles as sources of silicic acid favoring wound healing in vitro

Author: Thibaud Coradin, Sandrine Quignard, Ravin Jugdaohsingh, Jonathan J. Powell, Powell, Jonathan [0000-0003-2738-1715], Jugdaohsingh, Ravin [0000-0001-8074-2992], Apollo - University of Cambridge Repository, Matériaux et Biologie (MATBIO), Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Biomineral Research Group [Cambridge], MRC Elsie Widdowson Laboratory, Biomineral Research Group, Department of Veterinary Medicine [Cambridge], University of Cambridge [UK] (CAM)-Department of Veterinary Medicine, and Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)
Subjects: Silicon dioxide, Cell Survival, Silicic Acid, Nanoparticle, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, chemistry.chemical_compound, Colloid and Surface Chemistry, Cell Line, Tumor, medicine, [CHIM]Chemical Sciences, Organic chemistry, Humans, Silicic acid, Physical and Theoretical Chemistry, Amines, Fibroblast, Dissolution, Cell Proliferation, Drug Carriers, Wound Healing, Aqueous solution, Surfaces and Interfaces, General Medicine, Fibroblasts, 021001 nanoscience & nanotechnology, Silicon Dioxide, Silica nanoparticles, 0104 chemical sciences, medicine.anatomical_structure, chemistry, Biophysics, Nanoparticles, 0210 nano-technology, Wound healing, Drug carrier, Biotechnology
Abstract: International audience; There is good evidence that certain silicon-containing materials promote would healing and their common feature is the delivery of orthosilicic acid (Si(OH)4) either directly or following metabolism. In this respect, amorphous silica nanoparticles (NP), which dissolve in aqueous environments releasing up to 2 mM orthosilicic acid, may be appropriate ‘slow release’ vehicles for bioactive silicon. Here we studied the impact of silica NP suspensions (primary particles ∼ 10 nm) in undersaturated conditions (below 2 mM Si) with differing degrees of surface charge and dissolution rate on human dermal fibroblasts (CCD-25SK cells) viability, proliferation and migration in a cellular wound model. Silica was shown to be non-toxic for all forms and concentrations tested and whilst the anticipated stimulatory effect of orthosilicic acid was observed, the silica NPs also stimulated fibroblast proliferation and migration. In particular, the amine-functionalized particles promoted wound closure more rapidly than soluble orthosilicic acid alone. We suggest that this effect is related to easy cellular internalization of these particles followed by their intracellular dissolution releasing silicic acid at a faster rate than its direct uptake from the medium. Our findings indicate that amorphous silica-based NPs may favour the delivery and release of bioactive silicic acid to cells, promoting wound healing.
Published: 2019
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21. Nanoparticles of Low-Valence Vanadium Oxyhydroxides: Reaction Mechanisms and Polymorphism Control by Low-Temperature Aqueous Chemistry

Author: Mathieu Morcrette, Christine Surcin, Xavier Petrissans, Valérie Briois, David Portehault, Julie Besnardiere, Thierry Le Mercier, Sophie Cassaignon, François Ribot, Valérie Buissette, Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche de Chimie Paris (IRCP), Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Ministère de la Culture (MC), Matériaux Hybrides et Nanomatériaux (MHN), Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Synchrotron SOLEIL (SSOLEIL), Centre National de la Recherche Scientifique (CNRS), Laboratoire réactivité et chimie des solides - UMR CNRS 7314 (LRCS), Université de Picardie Jules Verne (UPJV)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Réseau sur le stockage électrochimique de l'énergie (RS2E), Université de Nantes (UN)-Aix Marseille Université (AMU)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Collège de France (CdF (institution))-Université de Picardie Jules Verne (UPJV)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Pau et des Pays de l'Adour (UPPA)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Université Grenoble Alpes (UGA), Centre de Recherches d'Aubervilliers, RHODIA, Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Université de Picardie Jules Verne (UPJV)-Institut de Chimie du CNRS (INC)-Aix Marseille Université (AMU)-Université de Pau et des Pays de l'Adour (UPPA)-Université de Nantes (UN)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Collège de France (CdF (institution))-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Université Grenoble Alpes (UGA)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Ministère de la Culture (MC), and Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)
Subjects: X-ray absorption spectroscopy, Reaction mechanism, Aqueous solution, Valence (chemistry), Aqueous chemistry, Absorption spectroscopy, Inorganic chemistry, Vanadium, chemistry.chemical_element, 02 engineering and technology, Vanadium oxides, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, Soft chemistry, 0104 chemical sciences, X-ray Absorption Spectroscopy, Inorganic Chemistry, chemistry, Nanoparticles, [CHIM]Chemical Sciences, Physical and Theoretical Chemistry, 0210 nano-technology, Hydrate
Abstract: International audience; An aqueous synthetic route at 95 °C is developed to reach selectively three scarcely reported vanadium oxyhydroxides. Häggite V2O3(OH)2, Duttonite VO(OH)2, and Gain’s hydrate V2O4(H2O)2 are obtained as nanowires, nanorods, and nanoribbons, with sizes 1 order of magnitude smaller than previously reported. X-ray absorption spectroscopy provides evidence that vanadium in these phases is V+IV. Combined with FTIR, XRD, and electron microscopy, it yields the first insights into formation mechanisms, especially for Häggite and Gain’s hydrate. This study opens the way for further investigations of the properties of novel V+IV (oxyhydr)oxides nanostructures.
Published: 2016

22. 87Sr,119Sn,127I Single and {1H/19F}-Double Resonance Solid-State NMR Experiments: Application to Inorganic Materials and Nanobuilding Blocks

Author: Christel Gervais, Lionel Campayo, Christian Bonhomme, Danielle Laurencin, François Ribot, Mark E. Smith, Adrian J. Wright, Guillaume Renaudin, Jean-Marie Nedelec, John V. Hanna, Dinu Iuga, Annabelle R. Baker, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Spectroscopie, Modélisation, Interfaces pour L'Environnement et la Santé (SMiLES), Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), School of Chemistry University of Birmingham, University of Birmingham [Birmingham], Laboratoire d'études de Matériaux Céramiques pour le Conditionnement (LM2C), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), University of Warwick [Coventry], Lancaster University, Institut de Chimie de Clermont-Ferrand (ICCF), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-SIGMA Clermont (SIGMA Clermont)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), PICS QMAT, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC), and Solid State NMR Group, University of Warwick
Subjects: GIPAW, wideline NMR, Iodide, Inorganic chemistry, Analytical chemistry, chemistry.chemical_element, 02 engineering and technology, WURST, 010402 general chemistry, 01 natural sciences, QD, Vanadate, QC, solid state NMR, chemistry.chemical_classification, Resonance, [CHIM.MATE]Chemical Sciences/Material chemistry, General Chemistry, Nuclear magnetic resonance spectroscopy, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Characterization (materials science), [CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry, chemistry, Solid-state nuclear magnetic resonance, 0210 nano-technology, Tin, Hybrid material
Abstract: International audience; 87Sr, 127I and 119Sn wideline NMR spectroscopy was successfully applied to inorganic and hybrid materials: (i) Sr derivatives of medicinal interest (Sr-malonate, Sr-pyrophosphates, mixed Ca,Sr-fluoroapatites); (ii) apatitic structures acting as host matrices for iodine; and (iii) Sn-derived oxo-clusters which can be used as inorganic nanobuilding blocks. The BRAIN (BRoadband Adiabatic INversion) CP (Cross Polarization) approach (by Schurko et al.) was applied to a non integer quadrupolar nucleus (87Sr, I=9/2). The sequence was used in combination with WURST (Wideband Uniform-Rate Smooth-Truncation) QCPMG (Quadrupolar Carr-Purcell Meiboom-Gill) for optimal sensitivity. We showed that 127I WURST QCPMG experiments were sufficiently sensitive to allow rapid characterization of the incorporation of iodide (I−) anions in lead vanadate/phosphate apatites, and that 127I acted as a sensitive probe for the description of local disorder. 1H/19F → 119Sn BRAIN CP was successfully applied to the detailed characterization of tin oxo-clusters, using 1H and 19F as spin baths. We demonstrated that BRAIN CP can be effectively used as a tool of spectral editing leading to the estimation of spatial proximities between 119Sn and 1H/19F nuclei.
Published: 2016

23. pH-Driven Self-Assembly of Acidic Microbial Glycolipids

Author: Mohamed Selmane, Patrick Le Griel, Susanne Zibek, Elisabeth Delbeke, Christian V. Stevens, Javier Pérez, Sophie Roelants, Wim Soetaert, Sylvain Prévost, Michael Guenther, Inge N. A. Van Bogaert, Niki Baccile, Publica, Spectroscopie, Modélisation, Interfaces pour L'Environnement et la Santé (SMiLES), Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC), European Synchrotron Radiation Facility (ESRF), Synchrotron SOLEIL (SSOLEIL), Centre National de la Recherche Scientifique (CNRS), SWING beamline, Biophysics Group (SWING), Synchrotron SOLEIL, SynBioC, Universiteit Gent = Ghent University [Belgium] (UGENT), Fraunhofer Institute for Interfacial Engineering and Biotechnology (Fraunhofer IGB), Fraunhofer (Fraunhofer-Gesellschaft), InBio, Department of Biochemical and Microbial Technology, Bio Base Europe Pilot Plant, Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and Universiteit Gent = Ghent University (UGENT)
Subjects: Cellobiose, Carboxylic acid, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, X-Ray Diffraction, Yeasts, Scattering, Small Angle, Ustilago, Electrochemistry, [CHIM]Chemical Sciences, Organic chemistry, General Materials Science, Micelles, Spectroscopy, chemistry.chemical_classification, Aqueous solution, Small-angle X-ray scattering, Vesicle, Bilayer, Fatty acid, Surfaces and Interfaces, Hydrogen-Ion Concentration, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 0104 chemical sciences, End-group, chemistry, Saturated fatty acid, Glycolipids, 0210 nano-technology, Acids, Hydrophobic and Hydrophilic Interactions
Abstract: International audience; Microbial glycolipids are a class of well-known compounds, but their self-assembly behavior is still not well understood. While the free carboxylic acid end group makes some of them interesting stimuli-responsive compounds, the sugar hydrophilic group and the nature of the fatty acid chain make the understanding of their self-assembly behavior in water not easy and highly unpredictable. Using cryo-transmission electron microscopy (cryo-TEM) and both pH-dependent in situ and ex situ small angle X-ray scattering (SAXS), we demonstrate that the aqueous self-assembly at room temperature (RT) of a family of β-d-glucose microbial glycolipids bearing a saturated and monounsaturated C18 fatty acid chain cannot be explained on the simple basis of the well-known packing parameter. Using the “pH-jump” process, we find that the molecules bearing a monosaturated fatty acid forms vesicles below pH 6.2, as expected, but the derivative with a saturated fatty acid forms infinite bilayer sheets below pH 7.8, instead of vesicles. We show that this behavior can be explained on the different bilayer membrane elasticity as a function of temperature. Membranes are either flexible or stiff for experiments performed at a temperature respectively above or below the typical melting point, TM, of the lipidic part of each compound. Finally, we also show that the disaccharide-containing acidic cellobioselipid forms a majority of chiral fibers, instead of the expected micelles.
Published: 2016

24. Modeling the attenuated total reflectance infrared (ATR-FTIR) spectrum of apatite

Author: Etienne Balan, Christian Brouder, Loïc Ségalen, Julie Aufort, Christel Gervais, Institut de minéralogie, de physique des matériaux et de cosmochimie (IMPMC), Muséum national d'Histoire naturelle (MNHN)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de recherche pour le développement [IRD] : UR206-Centre National de la Recherche Scientifique (CNRS), Biominéralisations et environnements sédimentaires (BES), Institut des Sciences de la Terre de Paris (iSTeP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Spectroscopie, Modélisation, Interfaces pour L'Environnement et la Santé (SMiLES), Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Labex Matisse, ANR-11-IDEX-0004,SUPER,Sorbonne Universités à Paris pour l'Enseignement et la Recherche(2011), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de recherche pour le développement [IRD] : UR206-Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS), and Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)
Subjects: Infrared, Analytical chemistry, Physics::Optics, Infrared spectroscopy, Effective medium, Bruggeman model, 02 engineering and technology, 010502 geochemistry & geophysics, 01 natural sciences, Apatite, Geochemistry and Petrology, General Materials Science, Fourier transform infrared spectroscopy, 0105 earth and related environmental sciences, [PHYS]Physics [physics], Chemistry, Fluorapatite, [CHIM.MATE]Chemical Sciences/Material chemistry, Fresnel equations, 021001 nanoscience & nanotechnology, Wavelength, visual_art, Attenuated total reflection, visual_art.visual_art_medium, Attenuated total reflectance, 0210 nano-technology, ATR-FTIR, [SDU.STU.MI]Sciences of the Universe [physics]/Earth Sciences/Mineralogy
Abstract: International audience; Attenuated total reflectance (ATR) infrared spectra were measured on a synthetic and a natural fluorapatite sample. A modeling approach based on the computation of the Fresnel reflection coefficient between the ATR crystal and the powder sample was used to analyze the line shape of the spectra. The dielectric properties of the samples were related to those of pure fluorapatite using an effective medium approach, based on Maxwell–Garnett and Bruggeman models. The Bruggeman effective medium model leads to a very good agreement with the experimental data recorded on the synthetic fluorapatite sample. The poorer agreement observed on the natural sample suggests a more significant heterogeneity of the sample at a characteristic length scale larger than the mid-infrared characteristic wavelength, i.e., about 10 micrometers. The results demonstrate the prominent role of macroscopic electrostatic effects over fine details of the microscopic structure in determining the line shape of strong ATR bands.
Published: 2016

25. Rapid and reliable diagnosis of Wilson disease using X‐ray fluorescence

Author: Jean-Charles Duclos-Vallée, Françoise Schmitt, Catherine Guettier, Slavka Kascakova, Tuan Huy Nguyen, Andrea Somogyi, Cameron M. Kewish, Christophe Sandt, Didier Samuel, Joël Poupon, Emmanuel Jacquemin, Dominique Bazin, Bruno Francou, François Le Naour, Stéphan Rouzière, Rodolphe Sobesky, Anne Dubart-Kupperschmitt, Physiopathologie et traitement des maladies du foie, Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Hepatinov (DHU), Université Paris-Sud - Paris 11 (UP11)-Centre Hépato-Biliaire Paul Brousse, Ligne de lumière NANOSCOPIUM, Synchrotron SOLEIL, Laboratoire de Physique des Solides (LPS), Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11), Centre de Recherche en Transplantation et Immunologie (U1064 Inserm - CRTI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Hémodynamique, Interaction Fibrose et Invasivité tumorales Hépatiques (HIFIH), Université d'Angers (UA), Centre hépato-biliaire (CHB), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de Référence pour la maladie de Wilson (CNR wilson), CNR Wilson, Service de Neurologie, Hôpital Lariboisière, Laboratoire de toxicologie biologique [AP-HP], Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Ligne de lumière SMIS, Service de Génétique Moléculaire Pharmacogénétique et Hormonologie, Hôpital Bicêtre, Service d’Hépatologie et de Transplantation Hépatique Pédiatriques, AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Spectroscopie, Modélisation, Interfaces pour L'Environnement et la Santé (SMiLES), Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC), Service d’Anatomo-Pathologie [AP-HP], Hôpital Paul Brousse, d'Eggis, Gilles, Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), and Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Subjects: 0301 basic medicine, [SDV.MHEP.AHA] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Pathology, medicine.medical_specialty, Cirrhosis, diagnosis, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, chemistry.chemical_element, X-ray fluorescence, Zinc, X‐ray fluorescence spectroscopy, Pathology and Forensic Medicine, 03 medical and health sciences, 0302 clinical medicine, Cholestasis, [SDV.MHEP.AHA]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], medicine, Wilson disease, [SDV.IB] Life Sciences [q-bio]/Bioengineering, Elemental composition, [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, Original Articles, Long evans, medicine.disease, Copper, [SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, Paraffin embedded, 3. Good health, X-ray fluorescence spectroscopy, 030104 developmental biology, chemistry, copper, Original Article, [SDV.IB]Life Sciences [q-bio]/Bioengineering, 030217 neurology & neurosurgery
Abstract: International audience; Wilson's disease (WD) is a rare autosomal recessive disease due to mutations of the gene encoding the copper-transporter ATP7B. The diagnosis is hampered by the variability of symptoms induced by copper accumulation , the inconstancy of the pathognomonic signs and the absence of a reliable diagnostic test. We investigated the diagnostic potential of X-ray fluorescence (XRF) that allows quantitative analysis of multiple elements. Studies were performed on animal models using Wistar rats (n = 10) and Long Evans Cinnamon (LEC) rats (n = 11), and on human samples including normal livers (n = 10), alcohol cirrhosis (n = 8), haemo-chromatosis (n = 10), cholestasis (n = 6) and WD (n = 22). XRF experiments were first performed using synchrotron radiation to address the elemental composition at the cellular level. High-resolution mapping of tissue sections allowed measurement of the intensity and the distribution of copper, iron and zinc while preserving the morphology. Investigations were further conducted using a laboratory X-ray source for irradiating whole pieces of tissue. The sensitivity of XRF was highlighted by the discrimination of LEC rats from wild type even under a regimen using copper deficient food. XRF on whole formalin-fixed paraffin embedded needle biopsies allowed profiling of the elements in a few minutes. The intensity of copper related to iron and zinc significantly discriminated WD from other genetic or chronic liver diseases with 97.6% specificity and 100% sensitivity. This study established a definite diagnosis of Wilson's disease based on XRF. This rapid and versatile method can be easily implemented in a clinical setting.
Published: 2016

26. Degradation and Crystallization of Cellulose in Hydrogen Chloride Vapor for High-Yield Isolation of Cellulose Nanocrystals

Author: Paavo A. Penttilä, Ritva Serimaa, Janne Ruokolainen, Jani-Markus Malho, Anne Meriluoto, Thomas Rosenau, Eero Kontturi, Niki Baccile, Janne Laine, Herbert Sixta, Antje Potthast, Aalto University, Imperial College London, UPM-Kymmene Corporation, University of Helsinki, Spectroscopie, Modélisation, Interfaces pour L'Environnement et la Santé (SMiLES), Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC), University of Natural Resources and Life Sciences [Wien] (BOKU), Université médicale de Vienne, Autriche, Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and Universität für Bodenkultur Wien = University of Natural Resources and Life [Vienne, Autriche] (BOKU)
Subjects: Materials science, Inorganic chemistry, ta221, 02 engineering and technology, Cellobiose, 010402 general chemistry, 01 natural sciences, Catalysis, Nanomaterials, law.invention, chemistry.chemical_compound, Crystallinity, Adsorption, law, Polysaccharides, [CHIM]Chemical Sciences, Biomass, Cellulose, Crystallization, Hydrogen chloride, Hydrolysis, General Chemistry, Interfacial reactions, 021001 nanoscience & nanotechnology, 0104 chemical sciences, chemistry, Acid hydrolysis, 0210 nano-technology
Abstract: International audience; Despite the structural, load-bearing role of cellulose in the plant kingdom, countless efforts have been devoted to degrading this recalcitrant polysaccharide, particularly in the context of biofuels and renewable nanomaterials. Herein, we show how the exposure of plant-based fibers to HCl vapor results in rapid degradation with simultaneous crystallization. Because of the unchanged sample texture and the lack of mass transfer out of the substrate in the gas/solid system, the changes in the crystallinity could be reliably monitored. Furthermore, we describe the preparation of cellulose nanocrystals in high yields and with minimal water consumption. The study serves as a starting point for the solid-state tuning of the supramolecular properties of morphologically heterogeneous biological materials.
Published: 2016

27. Silica core–shell particles for the dual delivery of gentamicin and rifamycin antibiotics

Author: Andrea Mathilde Mebert, Martín F. Desimone, Sabrina Flor, Silvia Edith Lucangioli, Carole Aimé, Yupeng Shi, Gisela Solange Alvarez, Thibaud Coradin, Instituto de Química y Metabolismo del Fármaco [Buenos Aires] (IQUIMEFA), Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] (CONICET)-Facultad de Farmacia y Bioquímica [Buenos Aires] (FFYB), Universidad de Buenos Aires [Buenos Aires] (UBA)-Universidad de Buenos Aires [Buenos Aires] (UBA), Universidad de Buenos Aires [Buenos Aires] (UBA), Matériaux et Biologie (MATBIO), Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] (CONICET), and Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)
Subjects: Materials science, Biomedical Engineering, Nanotechnology, 02 engineering and technology, engineering.material, 010402 general chemistry, 01 natural sciences, Hydrophobic effect, Coating, medicine, General Materials Science, Rifamycin, Sorption, [CHIM.MATE]Chemical Sciences/Material chemistry, General Chemistry, General Medicine, 021001 nanoscience & nanotechnology, 0104 chemical sciences, [SDV.SP.PG]Life Sciences [q-bio]/Pharmaceutical sciences/Galenic pharmacology, Chemical engineering, Drug delivery, engineering, Surface modification, Gentamicin, 0210 nano-technology, Antibacterial activity, medicine.drug
Abstract: International audience; Increasing bacterial resistance calls for the simultaneous delivery of multiple antibiotics. One strategy is to design a unique pharmaceutical carrier that is able to incorporate several drugs with different physico-chemical properties. This is highly challenging as it may require the development of compartmentalization approaches. Here we have prepared core–shell silica particles allowing for the dual delivery of gentamicin and rifamycin. The effect of silica particle surface functionalization on antibiotic sorption was first studied, enlightening the role of electrostatic and hydrophobic interactions. This in turn dictates the chemical conditions for shell deposition and further sorption of these antibiotics. In particular, the silica shell deposition was favored by the positively charged layer of gentamicin coating on the core particle surface. Shell modification by thiol groups finally allowed for rifamycin sorption. The antibacterial activity of the core–shell particles against Staphylococcus aureus and Pseudomonas aeruginosa demonstrated the dual release and action of the two antibiotics.
Published: 2016

28. Hydration in silica based mesoporous materials: a DFT model

Author: Ivan Petit, Jarosław Handzlik, Frederik Tielens, Maciej Gierada, Chemistry, Faculty of Chemical Engineering and Technology, Cracow University of Technology, Spectroscopie, Modélisation, Interfaces pour L'Environnement et la Santé (SMiLES), Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC), Labex Matisse, ANR-11-IDEX-0004,SUPER,Sorbonne Universités à Paris pour l'Enseignement et la Recherche(2011), and Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Work (thermodynamics), Materials science, Computation, Ab initio, General Physics and Astronomy, [CHIM.MATE]Chemical Sciences/Material chemistry, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, 0104 chemical sciences, [CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry, Adsorption, Computational chemistry, Chemical physics, Molecule, Physical and Theoretical Chemistry, 0210 nano-technology, Mesoporous material
Abstract: International audience; The MCM-41 material is very commonly used as a support for catalysts. However, theoretical investigations are significantly limited due to the lack of appropriate models that well and accurately describe the real material and enable effective computation at the same time. In this work, our aim is to obtain calculable models at the DFT level of MCM-41 which are as close as possible to the real material. In particular the hydration degree has been investigated, and we present and characterize here for the first time a model for the MCM-41 unit cell filled with explicit solvent water molecules. This is particularly important, because the models developed here are aimed to be further applied in theoretical ab initio/DFT studies of adsorption or as a support for modelling active sites in catalysts.
Published: 2016

29. Applications: general discussion

Author: Christian Kuttner, Martin Mayer, Lucia Pasquato, Estefania Gonzalez Solveyra, M. Arturo López-Quintela, Richard A. L. Jones, Irene Yarovsky, Molly M. Stevens, Axel Mueller, David Portehault, Roland Faller, Luis M. Liz-Marzán, Marcin P. Grzelczak, Younan Xia, Euan Kay, Matthew Penna, Luciano Tadiello, Calum J. Drummond, Anna Roig, David French, Hedi Mattoussi, Antoine Thill, Heiko Wolf, Javier Reguera, Alberto Striolo, Guillermo González, Benjamin Abécassis, Leonardo Scarabelli, David Buceta, Yu Zhou, Mathias Brust, François Sicard, Catherine J. Murphy, Matériaux Hybrides et Nanomatériaux (MHN), Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC), Striolo, Alberto, Sicard, Francoi, Liz-Marzán, Lui, Murphy, Catherine, Roig, Anna, Mueller, Axel, Reguera, Javier, Zhou, Yu, Brust, Mathia, Scarabelli, Leonardo, Tadiello, Luciano, Thill, Antoine, Yarovsky, Irene, Mayer, Martin, López-Quintela, M. Arturo, Kuttner, Christian, Gonzalez Solveyra, Estefania, Wolf, Heiko, Kay, Euan, Pasquato, Lucia, Buceta, David, Portehault, David, Mattoussi, Hedi, González, Guillermo, Faller, Roland, French, David, Abécassis, Benjamin, Stevens, Molly, Xia, Younan, Jones, Richard, Grzelczak, Marcin, Penna, Matthew, Drummond, Calum, and Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Subjects: metallic nanocrystals, nanosized metal boride, lanthanide-based nanocluster, Mechanical engineering, nanosized metal borides, multiscale simulations, lanthanide-based nanoclusters, mixed-hydrogenated/fluorinated monolayers, lipid nanoparticles, multiscale simulation, Force field (chemistry), metallic nanocrystal, Molecular dynamics, [CHIM]Chemical Sciences, Physical and Theoretical Chemistry, mixed-hydrogenated/fluorinated monolayer
Abstract: International audience; Pas de résumé
Published: 2016

30. The interplay between calcite, amorphous calcium carbonate and intra-crystalline organics in sea urchin skeletal elements

Author: Mathieu Bennet, Emil Zolotoyabko, Marie Albéric, Luca Bertinetti, Nadine Nassif, Widad Ajili, Peter Fratzl, Yael Politi, El'ad N. Caspi, Thierry Azaïs, Alex Berner, Max Planck Institute of Colloids and Interfaces, Max-Planck-Gesellschaft, Spectroscopie, Modélisation, Interfaces pour L'Environnement et la Santé (SMiLES), Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Matériaux Hybrides et Nanomatériaux (MHN), Technion - Israel Institute of Technology [Haifa], and Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)
Subjects: 02 engineering and technology, Test (biology), 010402 general chemistry, 01 natural sciences, Paracentrotus lividus, law.invention, chemistry.chemical_compound, law, biology.animal, General Materials Science, Crystallization, Sea urchin, Calcite, biology, Chemistry, General Chemistry, [CHIM.MATE]Chemical Sciences/Material chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, biology.organism_classification, Amorphous calcium carbonate, 0104 chemical sciences, Chemical engineering, Anhydrous, 0210 nano-technology, Biomineralization
Abstract: International audience; Biomineralization processes in living organisms result in the formation of skeletal elements with complex ultrastructures. Although the formation pathways in sea urchin larvae are known, the interrelation between calcite, amorphous calcium carbonate (ACC), and intra-crystalline organics in adult sea urchin biominerals is less clear. Here, we study this interplay in the spines and test 2 plates of the Paracentrotus lividus sea urchins whose skeletal elements have optimized function-properties relationships. Thermogravimetric analysis coupled with differential scanning calorimetry or mass spectrometry measurements, nuclear magnetic resonance technique and high-resolution powder X-ray diffraction show that pristine spines and test plates are composed of Mg-rich calcite and comprise about 10 wt. % of anhydrous ACC, 1.2 to 1.6 wt. % of organics, and less than 0.2 wt. % of water. Anhydrous ACC originates from incomplete crystallization of a precursor ACC phase during biomineralization and is associated with intra-crystalline organics at the molecular level. Molecular interactions at organic/inorganic interfaces cause significant calcite lattice distortions of the tensile type. The latter are amplified during ACC crystallization and finally disappear after heat-assisted destruction of organic molecules. Converting the measured lattice distortions (strains) into internal stress components, we follow stress evolution upon annealing and find that complete crystallization of ACC leads to the isotropy of residual stresses in all investigated skeletal parts. These results allow us to speculate that organic macromolecules are preferentially attached to different crystallographic planes in the pristine test and spine samples.
Published: 2018

31. Implication of Water Molecules at the Silica – Ibuprofen Interface in Silica-Based Drug Delivery Systems Obtained through Incipient Wetness Impregnation

Author: Flavien Guenneau, Jean-Marie Devoisselle, Corine Tourné-Péteilh, Guillaume Laurent, Andrei Nossov, Kuldeep Panesar, Florence Babonneau, Cristina Sanfeliu Cano, Thierry Azaïs, Spectroscopie, Modélisation, Interfaces pour L'Environnement et la Santé (SMiLES), Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), and Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)
Subjects: Ibuprofen, 02 engineering and technology, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, 010402 general chemistry, 01 natural sciences, Fast release, chemistry.chemical_compound, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, medicine, Organic chemistry, Molecule, Physical and Theoretical Chemistry, Incipient wetness impregnation, Benzoic acid, solid state NMR, organic chemicals, Chemical exchange, Mesoporous silica, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Drug delivery systems, General Energy, [SDV.SP.PG]Life Sciences [q-bio]/Pharmaceutical sciences/Galenic pharmacology, chemistry, Chemical engineering, Drug delivery, Encapsulation, 0210 nano-technology, medicine.drug
Abstract: International audience; The dynamical behavior of ibuprofen or benzoic acid (model molecule of ibuprofen) encapsulated in mesoporous silica is very specific as a very high mobility is evidenced at ambient temperature due to the existence of confinement effect. In this contribution, we demonstrate through variable temperature 1H MAS NMR experiments that this specific dynamical behavior is also related to a fast chemical exchange that takes place between protons of the COOH group of the organic molecule and protons from water molecules at the surface of the silica for materials obtained through incipient wetness impregnation. This phenomenon implies a weak interaction between the guest molecule and the silica surface that is related to the fast release profile of encapsulated ibuprofen observed in vitro.
Published: 2017

32. Complex dewetting scenarios of ultrathin silicon films for large-scale nanoarchitectures

Author: Thomas David, Thomas Bottein, Ibtissem Fraj, Luc Favre, Marco Salvalaglio, Antoine Ronda, Monica Bollani, Isabelle Berbezier, David Grosso, Meher Naffouti, Rainer Backofen, Axel Voigt, Abdelmalek Benkouider, Mario Lodari, Marco Abbarchi, Institut des Matériaux, de Microélectronique et des Nanosciences de Provence (IM2NP), Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Micro-optoélectronique et Nanostructures [Monastir], Faculté des Sciences de Monastir (FSM), Université de Monastir - University of Monastir (UM)-Université de Monastir - University of Monastir (UM), Institute of Scientific Computing, Department of Mathematics, Technische Universität Dresden = Dresden University of Technology (TU Dresden), CNR Istituto di Fotonica e Nanotecnologie [Padova] (IFN), National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), Dipartimento di Fisica [Politecnico Milano] (POLIMI), Politecnico di Milano [Milan] (POLIMI), Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Consiglio Nazionale delle Ricerche [Roma] (CNR), Matériaux Hybrides et Nanomatériaux (MHN), Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Dipartimento di Fisica [Politecnico Milano], and Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)
Subjects: EBL, Materials science, Silicon, Materials Science, Microfluidics, chemistry.chemical_element, Nanotechnology, 02 engineering and technology, 01 natural sciences, UT-SOI, Monocrystalline silicon, Surface tension, 0103 physical sciences, Dewetting, [SPI.NANO]Engineering Sciences [physics]/Micro and nanotechnologies/Microelectronics, Thin film, 010306 general physics, Research Articles, Surface diffusion, patterning, Multidisciplinary, business.industry, SciAdv r-articles, 021001 nanoscience & nanotechnology, Semiconductor, chemistry, dewetting, 0210 nano-technology, business, Research Article
Abstract: Si-based nanoarchitectures are formed with unprecedented precision and reproducibility via templated dewetting of thin SOI., Dewetting is a ubiquitous phenomenon in nature; many different thin films of organic and inorganic substances (such as liquids, polymers, metals, and semiconductors) share this shape instability driven by surface tension and mass transport. Via templated solid-state dewetting, we frame complex nanoarchitectures of monocrystalline silicon on insulator with unprecedented precision and reproducibility over large scales. Phase-field simulations reveal the dominant role of surface diffusion as a driving force for dewetting and provide a predictive tool to further engineer this hybrid top-down/bottom-up self-assembly method. Our results demonstrate that patches of thin monocrystalline films of metals and semiconductors share the same dewetting dynamics. We also prove the potential of our method by fabricating nanotransfer molding of metal oxide xerogels on silicon and glass substrates. This method allows the novel possibility of transferring these Si-based patterns on different materials, which do not usually undergo dewetting, offering great potential also for microfluidic or sensing applications.
Published: 2017

33. Impact of Polyethylenimine Conjugation Mode on the Cell Transfection Efficiency of Silica Nanovectors

Author: Thibaud Coradin, Guillaume Laurent, Xiaolin Wang, Sylvie Masse, Christophe Hélary, Matériaux et Biologie (MATBIO), Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC), Spectroscopie, Modélisation, Interfaces pour L'Environnement et la Santé (SMiLES), China Scholarship Council, and Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Silicon dioxide, Genetic Vectors, Nanotechnology, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, macromolecular substances, 02 engineering and technology, Gene delivery, Transfection, 010402 general chemistry, 01 natural sciences, Mice, chemistry.chemical_compound, Electrochemistry, Animals, Humans, Polyethyleneimine, General Materials Science, Cytotoxicity, Cells, Cultured, Spectroscopy, Electrophoresis, Agar Gel, Polyethylenimine, technology, industry, and agriculture, 3T3 Cells, [CHIM.MATE]Chemical Sciences/Material chemistry, Surfaces and Interfaces, Silicon Dioxide, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 0104 chemical sciences, Sulfonate, Microscopy, Fluorescence, chemistry, Biophysics, Particle, Surface modification, 0210 nano-technology
Abstract: International audience; The conjugation of polyethylenimine (PEI) to silica nanoparticles has emerged as a useful strategy in gene delivery. Here we investigate the influence of the PEI conjugation mode on the transfection ability of plain silica nanoparticles. Surface functionalization with sulfonate- and chloride-bearing silanes modulates the amount and conformation of PEI and therefore the particles' affinity for the plasmid, without impacting on cytotoxicity. transfection efficiency in both immortalized and primary cells is more directly correlated to the nature and strength of the particle PEI interactions. It suggests that PEI detachment from the particle surface at the stage of endosomal escape is a key event in the plasmid delivery process. These data should provide fruitful guidelines for the fine tuning of colloidal surfaces intended for intracellular delivery of bioactive molecules.
Published: 2015

34. Recent Advances in Biomaterials for Tissue Engineering and Controlled Drug Delivery

Author: Christophe Hélary, Martín F. Desimone, Matériaux et Biologie (MATBIO), Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)
Subjects: medicine.medical_specialty, CIENCIAS MÉDICAS Y DE LA SALUD, Skin wound, Pharmaceutical Science, Biocompatible Materials, Gene delivery, Bioinformatics, Biomateriales, Biotecnología de la Salud, Biomaterials, Drug Delivery Systems, Tissue engineering, Antibiotics, Animals, Humans, Regeneration, Medicine, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Controlled drug delivery, Wound Healing, Cell phenotype, Tissue Engineering, business.industry, Regeneration (biology), Gene Transfer Techniques, [CHIM.MATE]Chemical Sciences/Material chemistry, 3. Good health, Surgery, Drug delivery, Intercellular Signaling Peptides and Proteins, MEDICATED DRESSINGS, Growth factors, business, Wound healing, Biotechnology
Abstract: In this review, recent advances in biomaterials developed to favor tissue repair are presented. The focus is particularly on devices used to promote bone repair, skin wound healing and nerve regeneration. In each case, the specifications for an ideal substitute and the recent advances in the field of these biomaterials are presented. Alternatively, drug delivery systems associated with biomaterials have been developed over the recent decades to stimulate wound healing without any side effects. For this purpose, the overview presents recent advances in medicated dressings for controlled release of antibiotic to prevent infections, growth factors to promote tissue regeneration and gene delivery to modulate cell phenotype. Fil: Hélary, Christophe. Universite de Paris Vi; Francia. Centre National de la Recherche Scientifique; Francia Fil: Desimone, Martín Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Published: 2015

35. Sol-gel Encapsulation of Biomolecules and Cells for Medicinal Applications

Author: Martín F. Desimone, Xiaolin Wang, María Victoria Tuttolomondo, Christophe Hélary, Nada Ben Ahmed, Gisela Solange Alvarez, Thibaud Coradin, Matériaux et Biologie (MATBIO), Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC), CNRS, Chinese Scientific Council, Argentina-France MINCYT-ECOS-Sud [A12S01], CONICET-CNRS programs, and Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Chemistry, Pharmaceutical, Drug Compounding, Nanotechnology, Biosensing Techniques, INGENIERÍAS Y TECNOLOGÍAS, Phase Transition, Biotecnología Industrial, Bioreactors, Tissue engineering, Sol gel, Drug Discovery, Animals, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Sol-gel, chemistry.chemical_classification, Drug Carriers, Bioproductos, Biomateriales, Bioplásticos, Biocombustibles, Bioderivados, etc, Biomolecule, [CHIM.MATE]Chemical Sciences/Material chemistry, General Medicine, Cells, Immobilized, Silicon Dioxide, Anti-Bacterial Agents, Encapsulation (networking), Immobilized Proteins, Biosensors, chemistry, Delayed-Action Preparations, Nucleic acid, Nanoparticles, Encapsulation, Drug, Hybrid material, Gels, Delivery, Biosensor
Abstract: The sol-gel process provides a robust and versatile technology for the immobilization of biologicals. A wide range of inorganic, composites and hybrid materials can be prepared to encapsulate molecular drugs, proteins, antibodies/antigens, enzymes, nucleic acids, prokaryotic and eukaryotic cells into bulk gels, particles and films. This review describes the applications of sol-gel encapsulation relevant to medicinal chemistry focusing on the recent development of biosensors as well as systems for production, screening and delivery of bioactive compounds and biomaterials. Fil: Wang, Xiaolin. Universite de Paris VI; Francia. Centre National de la Recherche Scientifique; Francia Fil: Ahmed, Nada Ben. Université Paris Diderot - Paris 7; Francia. Centre National de la Recherche Scientifique; Francia Fil: Alvarez, Gisela Solange. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina Fil: Tuttolomondo, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina Fil: Hélary, Christophe. Université Paris Diderot - Paris 7; Francia. Universite de Paris VI; Francia Fil: Desimone, Martín Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina Fil: Coradin, Thibaud. Universite de Paris VI; Francia. Centre National de la Recherche Scientifique; Francia
Published: 2015

36. From Tendon Injury to Collagen-based Tendon Regeneration: Overview and Recent Advances

Author: Clément Rieu, Lise Picaut, Léa Trichet, Gervaise Mosser, Matériaux et Biologie (MATBIO), Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Mécanique multi-échelles des solides faibles (INSP-E7), Institut des Nanosciences de Paris (INSP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), and Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)
Subjects: collagen, musculoskeletal diseases, Scaffold, medicine.medical_specialty, tendon, injury, 02 engineering and technology, scaffold, 010402 general chemistry, 01 natural sciences, Tendons, Biomimetics, Tendon Injuries, Drug Discovery, Animals, Humans, Regeneration, Medicine, [SDV.IB.BIO]Life Sciences [q-bio]/Bioengineering/Biomaterials, Pharmacology, Tissue Scaffolds, business.industry, Regeneration (biology), biomaterial, musculoskeletal system, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Tendon, Surgery, medicine.anatomical_structure, [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, repair, graft, Printing, Three-Dimensional, 0210 nano-technology, business, Biomedical engineering
Abstract: International audience; Tendon injury is a clinical, societal and economical issue. Moreover, tendon repair represents an important clinical challenge, partly due to the mechanical constraints that occur at the junctions with muscle and bone. Several strategies have been developed for tendon repair. In this review, we first assess the importance of tendon injuries from different sites and their causes. After a short overview of tendon three-dimensional organization, the complexity of the perfect repair quest is presented ranging from current clinical procedures to new engineering scaffolds. We then sum up tendon engineering requirements and focus on new collagen-based scaffolds, which raise promising prospects to mimic and repair tendon. In particular, we survey quantitatively a large panel of techniques to produce these scaffolds, detailing their principle and recent improvements.
Published: 2017

37. Oil shale powders and their interactions with ciprofloxacin, ofloxacin, and oxytetracycline antibiotics

Author: Abdelaziz Laghzizil, Sanaa Saoiabi, A. Rami, Guillaume Laurent, Miloud El Karbane, Asmae Gouza, Sylvie Masse, A. Saoiabi, Thibaud Coradin, Laboratoire de Chimie physique Générale, Université Mohammed V de Rabat [Agdal] (UM5), Laboratoire National de Contrôle des Médicaments, Rabat, Morocco, Matériaux et Biologie (MATBIO), Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Spectroscopie, Modélisation, Interfaces pour L'Environnement et la Santé (SMiLES), APATENV project of the PICS program., Université Mohammed V de Rabat [Agdal], and Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)
Subjects: Ofloxacin, Mineral sorbents, Health, Toxicology and Mutagenesis, Iron oxide, Oxytetracycline, 02 engineering and technology, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, 010501 environmental sciences, 01 natural sciences, Hydrophobic effect, chemistry.chemical_compound, Ciprofloxacin, Antibiotics, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, Specific surface area, medicine, Soil Pollutants, Environmental Chemistry, Organic matter, Quartz, Environmental Restoration and Remediation, 0105 earth and related environmental sciences, Solid state NMR, chemistry.chemical_classification, Oil shale, Minerals, Chromatography, Chemistry, Sorption, General Medicine, [CHIM.MATE]Chemical Sciences/Material chemistry, 021001 nanoscience & nanotechnology, Pollution, Anti-Bacterial Agents, Morocco, Retention, 13. Climate action, Environmental chemistry, Adsorption, Powders, 0210 nano-technology, Hydrophobic and Hydrophilic Interactions, medicine.drug
Abstract: International audience; The interaction of oil shale, as a widespread sedimentary rock, with common antibiotics ofloxacine, oxytetracycline, and ciprofloxacine was studied. The selected Moroccan deposit and its thermally treated forms were fully characterized from a chemical and structural point of view, indicating the prevalence of quartz as a mineral component together with aluminum- and iron-rich phase that are converted into Al-doped iron oxide phases upon heating. The presence of 4 wt% organics was also detected, which was removed at 550 °C without significant loss of specific surface area. The pseudo-second-order kinetic model and Langmuir equation were found the most adequate to reproduce the kinetics and isothermal sorption experiments. These analyses enlighten the contribution of the organic matter on antibiotic retention as well as the key role of hydrophobic interactions on the molecule-mineral surface interactions. Our results emphasize the possible contribution of raw oil shale in the accumulation of antibiotics in soils and suggest that thermally treated oil shell powders can constitute cheap mineral sorbents for environmental cleaning.
Published: 2017

38. Hydroxyapatites: Key Structural Questions and Answers from Dynamic Nuclear Polarization

Author: Christian Bonhomme, César Leroy, Cristina Coelho-Diogo, Satoshi Hayakawa, Akiyoshi Osaka, Laure Bonhomme-Coury, Florence Babonneau, Fabien Aussenac, Spectroscopie, Modélisation, Interfaces pour L'Environnement et la Santé (SMiLES), Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Bruker Biospin SA, Wissembourg, Okayama University of Science, Institut des matériaux de Paris-Centre (IMPC), Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), and Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)
Subjects: Questions and answers, Chemistry, Resolution (electron density), Nanoparticle, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, Polarization (waves), 01 natural sciences, 0104 chemical sciences, Analytical Chemistry, Crystallography, Orders of magnitude (time), Chemical physics, Spin diffusion, [CHIM]Chemical Sciences, Hydroxyapatites, 0210 nano-technology, Line (formation)
Abstract: International audience; We demonstrate that NMR/DNP (Dynamic Nuclear Polarization) allows an unprecedented description of carbonate substituted hydroxyapatite (CHAp). Key structural questions related to order/disorder and clustering of carbonates are tackled by using distance sensitive DNP experiments using 13 C-13 C recoupling. Such experiments are easily implemented due to unprecedented DNP gain (orders of magnitude). DNP is efficiently mediated by quasi one-dimensional spin diffusion through the hy-droxyl columns present in the CHAp structure (thought as "highways" for spin diffusion). For spherical nanoparti-cles and ∅ < 100 nm, it is numerically shown that spin diffusion allows their study as a whole. Most importantly, we demonstrate also that the DNP study at 100 K leads to data which are comparable to data obtained at room temperature (in terms of spin dynamics and lineshape resolution). Finally, all 2D DNP experiments can be interpreted in terms of domains exhibiting well identified types of substitution: local order and carbonate clustering are clearly favored.
Published: 2017

39. Hydrophobic Coatings by Thiol-Ene Click Functionalization of Silsesquioxanes with Tunable Architecture

Author: Sandra Dirè, Emanuela Callone, Devid Maniglio, François Ribot, Isabelle Génois, Davide Bottone, Dipartimento di Ingegneria Industriale, Università degli Studi di Trento (UNITN), Matériaux Hybrides et Nanomatériaux (MHN), Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC), and Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Materials science, Kinetics, thiol-ene click reaction, wettability, 02 engineering and technology, engineering.material, 010402 general chemistry, lcsh:Technology, 01 natural sciences, Article, cotton fabric, Coating, hydrophobic coatings, Organic chemistry, General Materials Science, lcsh:Microscopy, Ene reaction, Alkyl, lcsh:QC120-168.85, chemistry.chemical_classification, lcsh:QH201-278.5, lcsh:T, paper, [CHIM.MATE]Chemical Sciences/Material chemistry, in situ water production, silsesquioxanes, NMR, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Chemical engineering, chemistry, lcsh:TA1-2040, Yield (chemistry), Click chemistry, engineering, Surface modification, lcsh:Descriptive and experimental mechanics, lcsh:Electrical engineering. Electronics. Nuclear engineering, Wetting, lcsh:Engineering (General). Civil engineering (General), 0210 nano-technology, lcsh:TK1-9971
Abstract: International audience; The hydrolysis-condensation of trialkoxysilanes under strictly controlled conditions allows the production of silsesquioxanes (SSQs) with tunable size and architecture ranging from ladder to cage-like structures. These nano-objects can serve as building blocks for the preparation of hybrid organic/inorganic materials with selected properties. The SSQs growth can be tuned by simply controlling the reaction duration in the in situ water production route (ISWP), where the kinetics of the esterification reaction between carboxylic acids and alcohols rules out the extent of organosilane hydrolysis-condensation. Tunable SSQs with thiol functionalities (SH-NBBs) are suitable for further modification by exploiting the simple thiol-ene click reaction, thus allowing for modifying the wettability properties of derived coatings. In this paper, coatings were prepared from SH-NBBs with different architecture onto cotton fabrics and paper, and further functionalized with long alkyl chains by means of initiator-free UV-induced thiol-ene coupling with 1-decene (C10) and 1-tetradecene (C14). The coatings appeared to homogeneously cover the natural fibers and imparted a multi-scale roughness that was not affected by the click functionalization step. The two-step functionalization of cotton and paper warrants a stable highly hydrophobic character to the surface of natural materials that, in perspective, suggests a possible application in filtration devices for oil-water separation. Furthermore, the purification of SH-NBBs from ISWP by-products was possible during the coating process, and this step allowed for the fast, initiator-free, click-coupling of purified NBBs with C10 and C14 in solution with a nearly quantitative yield. Therefore, this approach is an alternative route to get sol-gel-derived, ladder-like, and cage-like SSQs functionalized with long alkyl chains.
Published: 2017

40. NMR safeguarding plan in case of major flooding of the Seine river

Author: Laurent, Guillaume, Babonneau, Florence, Spectroscopie, Modélisation, Interfaces pour L'Environnement et la Santé (SMiLES), Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)
Subjects: Major flooding, Safeguarding plan, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, Nuclear Magnetic Resonance, [SDE.ES]Environmental Sciences/Environmental and Society
Abstract: International audience; Jussieu site is located in Paris on the banks of the Seine river. 14 NMR spectrometers are ranging from 300 MHz to 700 MHz. 9 NMR are on the ground floor, 5 NMR are on higher floors. Their total cost is 7 M€. A quench will cost 40 k€ per spectrometer. Flooding of electronics is estimated to 200 k€ per spectrometer.Major flooding of the Seine river is a highly probable risk. The NMR platform could be strongly affected. The electronic cabinets need to be evacuated to higher floors. A good coordination is needed between NMR technical staff, campus cryogenics staff and campus technical staff. NMR staff comings and goings will get considerably more complicated.; Le site de Jussieu de Sorbonne Universités – Université Pierre et Marie Curie se situe en bordure de la Seine et risque d’être fortement impacté en cas de crue majeure du fleuve. Quatorze spectromètres de Résonance Magnétique Nucléaire (RMN) se trouvent dans cette faculté, pour un coût total de 7 M€. Deux éléments sont à protéger: l’électronique et le cryoaimant. En effet, la noyade de l’électronique entraînera sa destruction et l’absence de fourniture en fluides cryogéniques engendrerait un coût de 40 k€ par appareil.En Juin 2016, la Seine a connu une crue suffisante pour entrainer des perturbations dans les transports en commun de Paris. Toutefois il ne s’agissait que d’une crue mineure. Comment protéger le matériel en cas de crue majeure ?Dans cette communication, nous verrons l’historique des crues, leur mesure, leurs effets sur les RMN et les mesures préventives à mettre en œuvre, en lien avec le service technique et le service des basses températures de l’université.
Published: 2017

41. Surface-Induced Frustration in Solid State Polymorphic Transition of Native Cellulose Nanocrystals

Author: Niki Baccile, Reeta Salminen, Mehedi Reza, Eero Kontturi, Aalto University, Spectroscopie, Modélisation, Interfaces pour L'Environnement et la Santé (SMiLES), Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Department of Applied Physics, and Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)
Subjects: Polymers and Plastics, media_common.quotation_subject, Crystallization of polymers, Frustration, Bioengineering, 02 engineering and technology, 010402 general chemistry, Microscopy, Atomic Force, 01 natural sciences, Biomaterials, Crystal, chemistry.chemical_compound, symbols.namesake, image analysis, Polymer chemistry, Materials Chemistry, Cellulose, ta216, cellulose nanocrystals, media_common, polymorphic transition, Hydrogen Bonding, [CHIM.MATE]Chemical Sciences/Material chemistry, 021001 nanoscience & nanotechnology, Ethylenediamines, Silicon Dioxide, Exfoliation joint, 0104 chemical sciences, Cellulose nanocrystals, Chemical engineering, chemistry, symbols, host-guest system, Nanoparticles, Adsorption, van der Waals force, surface immobilization, 0210 nano-technology, Dispersion (chemistry)
Abstract: International audience; The presence of an interface generally influences crystallization of polymers from melt or from solution. Here, by contrast, we explore the effect of surface immobilization in a direct solid state polymorphic transition on individual cellulose nanocrystals (CNCs), extracted from a plant-based origin. The conversion from native cellulose I to cellulose III crystal occurred via a host-guest inclusion of ethylene diamine inside the crystal. 60% reduction in CNC width (height) in atomic force microscopy images suggested that when immobilized on a flat modified silica surface, the stresses caused by the inclusion or the subsequent regeneration resulted in exfoliation, hypothetically between the van der Waals bonded sheets within the crystal. Virtually no changes in dimensions were visible when the polymorphic transition was performed to non-immobilized CNCs in bulk dispersion. With reservations and by acknowledging the obvious dissimilarities, the exfoliation of cellulose crystal sheets can be viewed as analogous to exfoliation of 2D structures like graphene from a van der Waals stacked solid. Here, the detachment is triggered by an inclusion of a guest molecule inside a host cellulose crystal and the stresses caused by the firm attachment of the CNC on a solid substrate, leading to detachment of molecular sheets or stacks of sheets.
Published: 2017

42. Water/ice phase transition: The role of zirconium acetate, a compound with ice-shaping properties

Author: Francisco Fernandes, Sylvain Deville, Dmytro Dedovets, Moreno Marcellini, Laboratoire de Synthèse et Fonctionnalisation de Céramiques (LSFC), Saint Gobain-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Matériaux et Biologie (MATBIO), Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Saint-Gobain-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)
Subjects: Phase transition, Materials science, Base (chemistry), FOS: Physical sciences, General Physics and Astronomy, chemistry.chemical_element, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Differential scanning calorimetry, Colligative properties, Molecule, Physical and Theoretical Chemistry, chemistry.chemical_classification, Condensed Matter - Materials Science, Zirconium, Ice crystals, Materials Science (cond-mat.mtrl-sci), 021001 nanoscience & nanotechnology, 0104 chemical sciences, 3. Good health, [CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry, Temperature gradient, chemistry, Chemical engineering, 0210 nano-technology
Abstract: Few compounds feature ice-shaping properties. The only compound reported to have ice-shaping properties similar to that of ice-shaping proteins, encountered in many organisms living at low temperature, is Zirconium Acetate. When a Zirconium Acetate solution is frozen, oriented and perfectly hexagonal ice crystals can be formed and their growth follows the temperature gradient. To shed light on the water/ice phase transition while freezing Zirconium Acetate solution we carried out differential scanning calorimetry measurements. From our results, we estimate how many water molecules do not freeze because of their interaction with Zr cations. We estimate the colligative properties of the Zr concentration on the apparent critical temperature. We further show the phase transition is unaffected by the nature of the base which is used to adjust the pH. Our results provide thus new hints on the ice-shaping mechanism of Zirconium Acetate., Comment: 12 pages, 5 figures
Published: 2017

43. Sulfonic Acid Functionalized Chitosan as a Sustainable Component for Proton Conductivity Management in PEMs

Author: Mustapha Raihane, Ozlem Sel, Hubert Perrot, Mohammed Lahcini, Natacha Krins, Ibtissam Ressam, Mohamed Selmane, Christel Laberty-Robert, Abdelkrim El Kadib, Laboratoire Interfaces et Systèmes Electrochimiques (LISE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Université Cadi Ayyad [Marrakech] (UCA), Matériaux Hybrides et Nanomatériaux (MHN), Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC), Euromed Research Center. Engineering Division [Fès], Université Euro Méditerranéenne de Fès (UEMF), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Subjects: chemistry.chemical_classification, Materials science, Proton, 02 engineering and technology, General Chemistry, Polymer, Activation energy, Sulfonic acid, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, 0104 chemical sciences, Chitosan, chemistry.chemical_compound, Membrane, chemistry, Chemical engineering, Proton transport, Nafion, Polymer chemistry, [CHIM]Chemical Sciences, 0210 nano-technology
Abstract: International audience; One of the most fundamental assets of natural polysaccharides is their water storage capacity. Analogically, materials able to regulate water hydration in energetic systems (e.x.: fuel-cells) are of paramount interest. In light of this key characteristic, chitosan, an aminocarbohydrate derived from shellfish waste, was structurally conjugated using sulfosuccinic acid to afford CS-SO3H. The resulting polymeric material appears well suitable for enhancing proton conduction and tuning the hydrophilic-hydrophobic balance of the proton exchange membranes (PEM). Consequently, Nafion membrane modified with CS-SO3H presented σH+ values almost 2 times higher than that of pristine Nafion at every % RH level exposed (30 °C - 80 °C and 30% - 90%). The σH+ enhancement is in agreement with the lower activation energy indicating that the proton transport is facilitated in the presence of -SO3H modified chitosan. We have found indications that –SO3H modified chitosan polymer, as a sustainable additive to Nafion is able to control the proton conduction mechanism and keep the activation energy for proton conduction at lower values as compared to pristine Nafion.
Published: 2017

44. Benefit of Rare-Earth 'Smart Doping' and Material Nanostructuring for the Next Generation of Er-Doped Fibers

Author: Bruno Capoen, Laurent Bigot, Alain Pastouret, Corinne Chanéac, Cedric Gonnet, Ekaterina Burova, Hicham El-Hamzaoui, Inna Savelii, Mohamed Bouazaoui, Laboratoire de Physique des Lasers, Atomes et Molécules - UMR 8523 (PhLAM), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Prysmian Group, Matériaux Hybrides et Nanomatériaux (MHN), Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Saint-Gobain Recherche (SGR), Saint-Gobain, ANR-12-RMNP-0019,NANOFIBER,NANOstructuration de matériaux destinés à la réalisation d'une nouvelle génération de FIBres optiques amplificatrices dopées Erbium and Erbium/Ytterbium (NANOFIBER)(2012), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC), and SAINT-GOBAIN
Subjects: Oxide nanoparticles, Optical fiber, Materials science, Fabrication, chemistry.chemical_element, Nanotechnology, Context (language use), 02 engineering and technology, 01 natural sciences, law.invention, 010309 optics, Erbium, Materials Science(all), law, 0103 physical sciences, Erbium-doped optical fiber amplifier, General Materials Science, Fiber, Photoluminescence, Quenching, Optical amplifier, [PHYS]Physics [physics], Nano Express, Doping, Material nanostructuring, 021001 nanoscience & nanotechnology, Condensed Matter Physics, chemistry, 0210 nano-technology
Abstract: International audience; Erbium-doped fiber amplifiers (EDFAs) for harsh environments require to develop specific fabrication methods of Er 3+-doped fibers (EDFs) so as to limit the impact of radiation-induced absorption. In this context, a compromise has to be found between the concentration of Erbium and the glass composition. On the one hand, high concentration of Er 3+ ions helps to reduce the length of the EDF and hence the cumulated attenuation but generally leads to luminescence quenching mechanisms that limit the performances. On the other hand, so as to avoid such quenching effect, glass modifiers like Al 3+ or P 5+ ions are used in the fabrication of commercial EDFs but are not suitable for applications in harsh environment because these glass modifiers are precursors of radiation-induced structural defects and consequently of optical losses. In this work, we investigate the concept of smart doping via material nanostructuring as a way to fabricate more efficient optical devices. This approach aims at optimizing the glass composition of the fiber core in order to use the minimal content of glass modifiers needed to reach the suited level of performances for EDFA. Er 3+-doped alumina nanoparticles (NPs), as precursor of Er 3+ ions in the preform fabrication process, were used to control the environment of rare-earth ions and their optical properties. Structural and optical characterizations of NP-doped preforms and optical fibers drawn from such preforms demonstrate the interest of this approach for small concentrations of aluminum in comparison to similar glass compositions obtained by a conventional technique.
Published: 2017

45. Development of a Cradle-to-Grave Approach for Acetylated Acidic Sophorolipid Biosurfactants

Author: Christopher A. Mitchell, Bernd Everaert, Wim Soetaert, Katarzyna Ciesielska, Bart Devreese, Lasse Six, Georgia Eleni Tsotsou, Florence Babonneau, Helen Lydon, Anne-Sophie Cuvier, Brecht Vanlerberghe, Inge N. A. Van Bogaert, Roger Marchant, Sophie Roelants, Georgios Tsatsos, Niki Baccile, Elke Theeuwes, Ibrahim M. Banat, Spectroscopie, Modélisation, Interfaces pour L'Environnement et la Santé (SMiLES), Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), University of Ulster, Laboratory for Protein Biochemistry and Biomolecular Engineering, Department of Biochemistry, Physiology and Microbiology, Universiteit Gent = Ghent University [Belgium] (UGENT), Bio Base Europe Pilot Plant, Faculty of Bioscience Engineering, Ghent University, Organic Waste Systems (OWS), Ecover Co-ordination Center NV, COSMETIC SP, Universiteit Gent = Ghent University (UGENT), and Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)
Subjects: 0301 basic medicine, General Chemical Engineering, Biology, 01 natural sciences, 03 medical and health sciences, Environmental Chemistry, [CHIM]Chemical Sciences, Low toxicity, 010405 organic chemistry, Renewable Energy, Sustainability and the Environment, business.industry, Sophorolipid, Starmerella bombicola, General Chemistry, Self-assembly, Biodegradation, Pulp and paper industry, 6. Clean water, Cradle to grave, 0104 chemical sciences, Biotechnology, 030104 developmental biology, Solubilization, Genetic engineering, Fermentation, Antimicrobial, Glycolipids, business, Life cycle analysis
Abstract: International audience; Microbial production of biosurfactants represents one of the most interesting alternatives to classical petrol-based compounds due to their low toxicity, high biodegradability, and biological production processes from renewable bioresources. However, some of the main drawbacks generally encountered are the low productivities and the small number of chemical structures available, which limit widespread application of biosurfactants. Although chemical derivatization of (microbial) biosurfactants offers opportunities to broaden the panel of available molecules, direct microbial synthesis is still the preferred option and the use of engineered strains is becoming a valid alternative. In this multidisciplinary work we show the entire process of conception, upscaling of fermentation (150 L) and sustainable purification (filtration), application (foaming, solubilization, antibacterial), and life cycle analysis of acetylated acidic sophorolipids, directly produced by the Starmerella bombicola esterase knock out yeast strain, rather than purified using chromatography from the classical, but complex, mixture of acidic and lactonic sophorolipids.
Published: 2017

46. A novel PAN/silazane hybrid polymer for processing of carbon-based fibres with extraordinary oxidation resistance

Author: Christel Gervais, Ricardo Antonio Francisco Machado, Olivier Flores, Rhett Kempe, Günter Motz, P. Furtat, Luiz Fernando Belchior Ribeiro, Universität Bayreuth, Spectroscopie, Modélisation, Interfaces pour L'Environnement et la Santé (SMiLES), Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC), CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior), DAAD (Deutscher Akademischer Austauschdienst) [PROBRAL 366/11], DFG (Deutsche Forschungsgemeinschaft) [MO851/10], and Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Thermogravimetric analysis, Materials science, chemistry.chemical_element, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Polysilazane, chemistry.chemical_compound, Organic chemistry, General Materials Science, Ceramic, Nanocomposite, Renewable Energy, Sustainability and the Environment, Polyacrylonitrile, General Chemistry, [CHIM.MATE]Chemical Sciences/Material chemistry, 021001 nanoscience & nanotechnology, 0104 chemical sciences, chemistry, Chemical engineering, visual_art, visual_art.visual_art_medium, Acrylonitrile, 0210 nano-technology, Carbon, Pyrolysis
Abstract: International audience; A novel hybrid polymer made up of acrylonitrile (AN) and a commercial available oligosilazane (ML33) was developed as a precursor for the processing of carbon-based fibres with extraordinary intrinsic oxidation stability up to 800 degrees C. While polyacrylonitrile is used as the typical precursor for carbon fibres, a polysilazane derived SiCN ceramic phase should lead to improved oxidation resistance. Thermogravimetric analysis demonstrated that depending on the AN/ML33 ratio the weight loss during pyrolysis is drastically reduced up to 63% due to crosslinking reactions between both components, confirmed by NMR spectroscopy investigations. Unexpectedly, with increasing AN content in the starting composition the thermal treatment up to 1500 degrees C leads to a change from amorphous C/SiCN to C/Si3N4 nanocomposites confirmed by NMR, XRD and TEM measurements. The homogeneously distributed ceramic phase within the carbon matrix is responsible for the extraordinary intrinsic oxidation stability of this new type of carbon-based fibre.
Published: 2017

47. Influence of Ionic Additives on Triclinic Calcium Pyrophosphate Dihydrate Precipitation

Author: Christian Bonhomme, Christèle Combes, Kemie Ley-Ngardigal, Christian Rey, Cristina Coelho-Diogo, Béatrice Biscans, Sébastien Teychené, Pierre Gras, Laboratoire de génie chimique [ancien site de Basso-Cambo] (LGC), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées, Centre interuniversitaire de recherche et d'ingenierie des matériaux (CIRIMAT), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC), Spectroscopie, Modélisation, Interfaces pour L'Environnement et la Santé (SMiLES), Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC), Institut des matériaux de Paris-Centre (IMPC), Université Pierre et Marie Curie - Paris 6 (UPMC)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Agence Nationale de la Recherche (CAPYROSIS project ) [ANR-12-BS08-0022-01], Laboratoire de Génie Chimique (LGC), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique - CNRS (FRANCE), Collège de France (FRANCE), Ecole Nationale Supérieure de Chimie de Paris - ENSCP (FRANCE), Ecole Supérieure de Physique et de Chimie Industrielles - ESPCI (FRANCE), Institut National Polytechnique de Toulouse - INPT (FRANCE), Université Pierre et Marie Curie, Paris 6 - UPMC (FRANCE), Université Toulouse III - Paul Sabatier - UT3 (FRANCE), and Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Subjects: musculoskeletal diseases, inorganic chemicals, Calcium pyrophosphate, Matériaux, Ionic bonding, Context (language use), 02 engineering and technology, Precipitation, Triclinic crystal system, 010402 general chemistry, 01 natural sciences, law.invention, chemistry.chemical_compound, [CHIM.GENI]Chemical Sciences/Chemical engineering, law, Phase (matter), General Materials Science, Crystallization, Solid state NMR, Precipitation (chemistry), Chemistry, Ionic additives, General Chemistry, [CHIM.MATE]Chemical Sciences/Material chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 0104 chemical sciences, Crystallography, Pseudogout, 0210 nano-technology, Nuclear chemistry
Abstract: International audience; Triclinic Calcium pyrophosphate dihydrate (t-CPPD) crystals are one of the two polymorphs of micro crystals that have been found in the joints of patients suffering from pseudogout. Howeyer, there is currently no treatment for inhibiting the formation of these crystals, which present a high inflammatory potential. In this context we studied in vitro the precipitation of t-CPPD in a stirred reactor under pH- and temperature-controlled conditions and determined the effect of selected biologically relevant ionic additives Mg2+, Cu2+, Fe3+, Zn2+, S2O32-) on its formation. The results showed that 1 mM Fe3+, Zn2+, Or Cu2+ induced the most significant Changes by partly inhibiting, the crystallization of t-CPPD and favoring the formation of an amorphous-CPP phase (98 Wt %) in the presence of Fe3+ or a monoclinic-CPPD phase (78 or 71 wt %, respectively) in the presence of Zn2+ or CO2. Correlations between P-31 solid-state NMR, XRD, and elemental analyses showed that the additive cations are inserted into the monoclinic-CPPD and/or amorphous-CPP phases. This study, which combines structural, morphological, and elemental analyses, paves the way toward a deeper comprehension of the role of ionic additives in preventing the formation of CPPD crystalline phases, and is a key step in long-term development of an effective therapeutic treatment.
Published: 2017

48. Molecular Picture of the Adsorption of Ibuprofen and Benzoic Acid on Hydrated Amorphous Silica through DFT-D Calculations Combined with Solid-State NMR Experiments

Author: Louis Bondaz, Christel Gervais, Frederik Tielens, Slavica Etemovic, Florence Babonneau, Nicolas Folliet, Thierry Azaïs, Spectroscopie, Modélisation, Interfaces pour L'Environnement et la Santé (SMiLES), Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC), Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and Chemistry
Subjects: Inorganic chemistry, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, MOLECULES, chemistry.chemical_compound, Adsorption, Monolayer, medicine, Molecule, Surface interactions, Physical and Theoretical Chemistry, Benzoic acid, Chemistry, 021001 nanoscience & nanotechnology, Ibuprofen, 0104 chemical sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, [CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry, General Energy, Solid-state nuclear magnetic resonance, silica, FUNCTIONALIZATION, Physical chemistry, Amorphous silica, 0210 nano-technology, Mesoporous material, medicine.drug
Abstract: International audience; The presented research work is devoted to the investigation of the adsorption properties of biologically active molecules in mesoporous silicas. In particular, the interaction of ibuprofen with unique hydrated and functionalized silica carriers is unraveled by means of DFT-D calculations and experimental NMR experiments. The effects of temperature, degree of hydration, and adsorption site have been analyzed in detail to provide a molecular scale description of the adsorption and vectorization of a well-known drug, ibuprofen, on functionalized silicas. We conclude that the hydrated state, by the presence of a monolayer of water surface molecules on silica, plays the starring role.
Published: 2017

49. 1,2,3-Benzotriazole derivatives adsorption on Cu(1 1 1) surface: A DFT study

Author: Frederik Tielens, Carlos Escobar, Fernanda Ocayo, Mario Saavedra-Torres, Juan C. Santos, Departamento de Ciencias Químicas, Universidad Andrés Bello [Santiago] (UNAB), Spectroscopie, Modélisation, Interfaces pour L'Environnement et la Santé (SMiLES), Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Chemistry, General Chemistry, and Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)
Subjects: Passivation, Inorganic chemistry, Substituent, General Physics and Astronomy, chemistry.chemical_element, Context (language use), 02 engineering and technology, Physics and Astronomy(all), 010402 general chemistry, 01 natural sciences, DFT, chemistry.chemical_compound, Adsorption, Dibenzyl Disulfide, Physical and Theoretical Chemistry, Benzotriazole, 021001 nanoscience & nanotechnology, Copper, 0104 chemical sciences, Corrosion, [CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry, chemistry, Erosion corrosion of copper water tubes, Solvent effects, 0210 nano-technology
Abstract: International audience; In the context of copper corrosion passivation, the adsorption of benzotriazole (BTAH) and its derivatives: 5-Methyl, 5-Amine, 1-Amine, 1-Methyl on a Cu(111) surface was investigated using periodic density functional (DFT) calculations. The results were contrasted with experimental ASTM protocols. Adsorption of BTAH and radical (BTA●) forms, as well as solvent effect were evaluated. The Cu-N interaction provides stable complexes with adsorption over top sites. Radical forms yielded more stable complex. Their adsorption energies correlate with the substituent position and electronic features. And finally, a strong interaction was obtained when the charge transfer goes from surface to adsorbate.
Published: 2017

50. Nanostructured Y 2 O 3 ceramics elaborated by Spark Plasma Sintering of nanopowder synthesized by PEG assisted combustion method: The influence of precursor morphological characteristics

Author: B. Viana, Damien Bregiroux, Radenka Krsmanović Whiffen, Vinča Institute of Nuclear Sciences, University of Belgrade [Belgrade], Institut de Recherche de Chimie Paris (IRCP), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Ministère de la Culture (MC), Matériaux Hybrides et Nanomatériaux (MHN), Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Ministère de la Culture (MC), and Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Institut de Chimie du CNRS (INC)
Subjects: Materials science, Annealing (metallurgy), Sintering, Spark plasma sintering, 02 engineering and technology, 01 natural sciences, 0103 physical sciences, Materials Chemistry, Ceramic, Composite material, Yttria-stabilized zirconia, A. Grain growth, 010302 applied physics, B. Electron microscopy, Process Chemistry and Technology, [CHIM.MATE]Chemical Sciences/Material chemistry, Atmospheric temperature range, 021001 nanoscience & nanotechnology, Microstructure, A. Sintering, Grain size, D. Y2O3, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, visual_art, Ceramics and Composites, visual_art.visual_art_medium, 0210 nano-technology
Abstract: Dense yttria ceramics were prepared by Spark Plasma Sintering of a nanopowder synthesized using a PEG assisted combustion method. Densification occurs between 800 degrees C and 900 degrees C without any additive. This corresponds to one of the lowest sintering temperature found in the literature for Y2O3. Because of a significant release of organic species, the Y2O3 precursors obtained by this synthesis route contains macropores that have a negative impact on the final microstructure. We show that the emergence of these macropores can be minimized by decreasing the annealing temperature used for the precursor powder (in a temperature range of 300-650 degrees C) as opposed to the usual 800 degrees C. Finally, a precursor annealed at 650 degrees C allows us to obtain fully dense ceramics, with a very fine and homogeneous microstructure (and a grain size around 300 nm). Vickers microhardness and fracture toughness were measured and discussed in relation to the microstructure of the ceramics.
Published: 2017

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