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1,649 results on '"V. White"'

3. Pancreatic nitric oxide and oxygen free radicals in the early stages of streptozotocin-induced diabetes mellitus in the rat

Author

E. González, J. Roselló-Catafau, A. Jawerbaum, D. Sinner, C. Pustovrh, J. Vela, V. White, C. Xaus, C. Peralta, and M. Gimeno

Subjects
streptozotocin diabetes, pancreas, oxidative stress, nitric oxide, Medicine (General), R5-920, Biology (General), QH301-705.5
Abstract

The objective of the present study was to explore the regulatory mechanisms of free radicals during streptozotocin (STZ)-induced pancreatic damage, which may involve nitric oxide (NO) production as a modulator of cellular oxidative stress. Removal of oxygen species by incubating pancreatic tissues in the presence of polyethylene glycol-conjugated superoxide dismutase (PEG-SOD) (1 U/ml) produced a decrease in nitrite levels (42%) and NO synthase (NOS) activity (50%) in diabetic but not in control samples. When NO production was blocked by N G-monomethyl-L-arginine (L-NMMA) (600 µM), SOD activity increased (15.21 ± 1.23 vs 24.40 ± 2.01 U/mg dry weight). The increase was abolished when the NO donor, spermine nonoate, was added to the incubating medium (13.2 ± 1.32). Lipid peroxidation was lower in diabetic tissues when PEG-SOD was added (0.40 ± 0.02 vs 0.20 ± 0.03 nmol/mg protein), and when L-NMMA blocked NOS activity in the incubating medium (0.28 ± 0.05); spermine nonoate (100 µM) abolished the decrease in lipoperoxide level (0.70 ± 0.02). We conclude that removal of oxygen species produces a decrease in pancreatic NO and NOS levels in STZ-treated rats. Moreover, inhibition of NOS activity produces an increase in SOD activity and a decrease in lipoperoxidation in diabetic pancreatic tissues. Oxidative stress and NO pathway are related and seem to modulate each other in acute STZ-induced diabetic pancreas in the rat.

Published
2000
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7. Practical, Multigram Preparation of Synthetically Useful, Enantiomerically Pure Building-Blocks from Quinic Acid

Author

Shen Tan, Ping Lan, Martin G. Banwell, and Lorenzo V. White

Subjects
1,2-addition, α,β-annulation, cross-coupling, cyclohexenone, enantiomerically pure, α-iodination, quinic acid, Chemistry, QD1-999
Abstract

The naturally abundant, enantiomerically pure cyclitol quinic acid has been converted into a synthetically useful enone in nearly quantitative yield using the operationally straightforward and reproducible protocols reported herein. The latter compound, which was obtained in multigram quantities, engages in a diastereoselective 1,2-addition reaction with a hydrazone-based nucleophile. Furthermore, a readily derived α-iodoenone participates in both cross-coupling and α,β-annulation reactions. The results reported here emphasize that the now practically accessible cyclohexenones are useful, enantiomerically pure building blocks for organic synthesis.

Published
2022
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8. VEGF-A, PDGF-BB and HB-EGF engineered for promiscuous super affinity to the extracellular matrix improve wound healing in a model of type 1 diabetes

Author

Michael J. V. White, Priscilla S. Briquez, David A. V. White, and Jeffrey A. Hubbell

Subjects
Medicine
Abstract

Abstract Chronic non-healing wounds, frequently caused by diabetes, lead to lower quality of life, infection, and amputation. These wounds have limited treatment options. We have previously engineered growth factors to bind to exposed extracellular matrix (ECM) in the wound environment using the heparin-binding domain of placental growth factor-2 (PlGF-2123–144), which binds promiscuously to ECM proteins. Here, in the type 1 diabetic (T1D) NOD mouse model, engineered growth factors (eGFs) improved both re-epithelialization and granulation tissue formation. eGFs were even more potent in combination, and the “triple therapy” of vascular endothelial growth factor-A (VEGF-PlGF-2123–144), platelet-derived growth factor-BB (PDGF-BB-PlGF-2123–144), and heparin-binding epidermal growth factor (HB-EGF-PlGF-2123–144) both improved wound healing and remained at the site of administration for significantly longer than wild-type growth factors. In addition, we also found that changes in the cellular milieu of a wound, including changing amounts of M1 macrophages, M2 macrophages and effector T cells, are most predictive of wound-healing success in the NOD mouse model. These results suggest that the triple therapy of VEGF-PlGF-2123–144, PDGF-BB-PlGF-2123–144, and HB-EGF-PlGF-2123–144 may be an effective therapy for chronic non-healing wounds in that occur as a complication of diabetes.

Published
2021
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10. Therapeutic use of α2-antiplasmin as an antifibrinolytic and hemostatic agent in surgery and regenerative medicine

Author

Jialu Liu, Ani Solanki, Michael J. V. White, Jeffrey A. Hubbell, and Priscilla S. Briquez

Subjects
Medicine
Abstract

Abstract The biomaterial fibrin is widely used as a clinical tissue sealant in surgery. In preclinical research, fibrin is also extensively studied as a carrier material for growth factor delivery. In these applications, premature fibrin degradation leads to recurrent bleeding, tissue dehiscence and limited regenerative efficacy. Therefore, fibrinolysis inhibitors have been added to clinical fibrin formulations, for example the bovine-derived serine protease inhibitor aprotinin. Aprotinin is additionally used as a hemostatic agent to prevent excessive bleeding during surgery, in this case protecting endogenous fibrin clots. Nevertheless, aprotinin use has been associated with serious safety issues. Here, we explore the use the human physiological fibrinolysis inhibitor α2-antiplasmin (α2PI) as a substitute for aprotinin. We evaluate the efficacy of α2PI in the three main applications of aprotinin. We first showed that recombinant α2PI can successfully prolong the durability of fibrin biomaterials as compared to aprotinin in a model of subcutaneous implantation in mice mimicking application as a tissue sealant. We then used α2PI to enhance the delivery of engineered vascular endothelial growth factor (VEGF)-A and platelet-derived growth factor (PDGF)-BB in fibrin in promoting diabetic wound healing, which lead to improved wound closure, granulation tissue formation and angiogenesis. Lastly, we demonstrated that α2PI can be as effective as aprotinin as an intravenous hemostatic agent to prevent blood loss, using a tail-vein bleeding model in mice. Therefore, we believe that engineering fibrin biomaterials or endogenous fibrin with α2PI can have a strong impact in surgery and regenerative medicine by providing a competitive substitute to aprotinin that is of human origin.

Published
2022
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11. Thoracobifemoral bypass for infrarenal aortic occlusion caused by retroperitoneal fibrosis

Author

Kathy K. Wang, MD, Rym El Khoury, MD, Axel Joob, MD, Chad E. Jacobs, MD, John V. White, MD, and Lewis B. Schwartz, MD

Subjects
Thoracobifemoral bypass, Aortic occlusion, Retroperitoneal fibrosis, Surgery, RD1-811, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Retroperitoneal fibrosis (RPF) is an uncommon fibrotic disorder that can cause pain, ureteral obstruction, deep venous thrombosis, hydrocele, and, rarely, aortic occlusion. Herein is described a 65-year-old man with aortic occlusion from idiopathic RPF who was treated with axillobifemoral bypass grafting, which failed in the intermediate term. On representation with critical claudication, he underwent thoracobifemoral bypass grafting via a lateral retroperitoneal tunnel created through a midline, infraumbilical counterincision. He was discharged home on postoperative day 5. This illustrates the successful use of thoracic aortic inflow to treat the aortoiliac occlusive complication of RPF.

Published
2022
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12. Transposition of left subclavian artery with reimplantation of isolated left vertebral artery before thoracic endovascular aneurysm repair for type B aortic dissection

Author

Michael Chaney, BS, Victor Martinez-Zavala, MD, Rym El Khoury, MD, Gaurang Joshi, MD, Chad E. Jacobs, MD, John V. White, MD, and Lewis B. Schwartz, MD

Subjects
Aberrant anatomy, Aortic dissection, TEVAR, Transposition, Surgery, RD1-811, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Understanding and recognizing anatomic anomalies of the aortic arch is important when planning extra-anatomic debranching before thoracic endovascular aortic repair. A rare anomaly is the left vertebral artery aberrantly arising from the aortic arch; found in ∼5% of adults. When present, the artery courses through the carotid sheath at a variable length before entering the third or fourth cervical transverse foramen. In the present report, we have described the case of a 49-year-old man with a symptomatic, enlarging type B aortic dissection with an aberrant left vertebral artery and the novel methods used to surgically correct his pathology.

Published
2022
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13. Preconception hemoglobin A1c concentration in healthy women is not associated with fecundability or pregnancy loss

Author

Jessica R. Zolton, D.O., Lindsey A. Sjaarda, Ph.D., Sunni L. Mumford, Ph.D., Tiffany L. Holland, B.A., Keewan Kim, Ph.D., Kerry S. Flannagan, Ph.D., Samrawit F. Yisahak, Ph.D., Stefanie N. Hinkle, Ph.D., Matthew T. Connell, D.O., Mark V. White, M.D., Neil J. Perkins, Ph.D., Robert M. Silver, M.D., Micah J. Hill, D.O., Alan H. DeCherney, M.D., and Enrique F. Schisterman, Ph.D.

Subjects
hemoglobin A1c, fecundability, pregnancy loss, preconception care, Diseases of the genitourinary system. Urology, RC870-923, Gynecology and obstetrics, RG1-991
Abstract

Objective: To examine the relationship of preconception hemoglobin A1c, a marker of cumulative exposure to glucose over the preceding 2–3 months, with time to pregnancy, pregnancy loss, and live birth among fecund women without diagnosed diabetes or other medical diseases. Design: A secondary analysis of a prospective cohort of women participating in the Effects of Aspirin in Gestation and Reproduction (EAGeR) trial. Setting: Four US academic medical centers. Patient(s): A total of 1,194 healthy women aged 18–40 years with a history of one or two pregnancy losses attempting spontaneous conception were observed for up to six cycles while attempting pregnancy and throughout pregnancy if they conceived. Intervention(s): Not applicable. Main Outcome Measure(s): Time to pregnancy, human chorionic gonadotropin pregnancy, clinical pregnancy, pregnancy loss, and live birth. Result(s): Although increasing preconception A1c level was associated with reduced fecundability (fecundability odds ratio [FOR] per unit increase in A1c 0.74; 95% confidence interval [CI] 0.57, 0.96) in unadjusted models and models adjusted for age, race, smoking and treatment arm (FOR 0.79; 95% CI 0.60, 1.04), results were attenuated after further adjustment for body mass index (FOR 0.91; 95% CI 0.68, 1.21). Preconception A1c levels among women without diagnosed diabetes were not associated with live birth or pregnancy loss. Conclusions(s): Among healthy women without diagnosed diabetes, we observed no association of A1c with live birth or pregnancy loss. The association between A1c and fecundability was influenced by body mass index, a strong risk factor for both diabetes and infertility. These data support current recommendations that preconception A1c screening should be reserved for patients with risk factors for diabetes. Clinical Trial Registration Number: ClinicalTrials.gov: NCT00467363.

Published
2022
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14. Lysoptosis is an evolutionarily conserved cell death pathway moderated by intracellular serpins

Author

Cliff J. Luke, Stephanie Markovina, Misty Good, Ira E. Wight, Brian J. Thomas, John M. Linneman, Wyatt E. Lanik, Olga Koroleva, Maggie R. Coffman, Mark T. Miedel, Qingqing Gong, Arlise Andress, Marlene Campos Guerrero, Songyan Wang, LiYun Chen, Wandy L. Beatty, Kelsey N. Hausmann, Frances V. White, James A. J. Fitzpatrick, Anthony Orvedahl, Stephen C. Pak, and Gary A. Silverman

Subjects
Biology (General), QH301-705.5
Abstract

Cliff Luke et al. report that lysoptosis is a eukaryotic stand-alone regulated cell death pathway. They identify that this new cell death modality predominates in the absence of neutralizing endogenous inhibitors.

Published
2022
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15. A simplified surgical approach for left ovarian vein transposition for the treatment of pelvic venous disease from nutcracker syndrome

Author

John V. White, MD and Connie Ryjewski, APN

Subjects
Nutcracker syndrome, Chronic pelvic pain, Ovarian vein, Surgery, RD1-811, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Nutcracker syndrome is becoming increasingly recognized as a cause of chronic pelvic pain. Several treatment options have been used, including renal vein or ovarian vein transposition to the more distal inferior vena cava and renal vein stenting. Concerned about the major scope of the surgical procedures as well as the implantation of a foreign body that must function for six to seven decades, we undertook to develop an all autogenous simpler surgical solution for the treatment of nutcracker syndrome. In 2013, we began performing left ovarian vein transposition to the left iliac vein. In our initial report, we used a minimally invasive robotic approach. For the past several years, we have used a simplified open approach to left ovarian vein transposition that takes advantage of the fact that the left ovarian vein naturally courses over the iliac vein. We have found this surgical treatment of nutcracker syndrome provides excellent relief from the associated symptoms.

Published
2021
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16. The ASKAP-EMU Early Science Project: 888 MHz radio continuum survey of the Large Magellanic Cloud

Author

Clara M Pennock, Jacco Th van Loon, Miroslav D Filipović, Heinz Andernach, Frank Haberl, Roland Kothes, Emil Lenc, Lawrence Rudnick, Sarah V White, Claudia Agliozzo, Sonia Antón, Ivan Bojičić, Dominik J Bomans, Jordan D Collier, Evan J Crawford, Andrew M Hopkins, Kanapathippillai Jeganathan, Patrick J Kavanagh, Bärbel S Koribalski, Denis Leahy, Pierre Maggi, Chandreyee Maitra, Josh Marvil, Michał J Michałowski, Ray P Norris, Joana M Oliveira, Jeffrey L Payne, Hidetoshi Sano, Manami Sasaki, Lister Staveley-Smith, and Eleni Vardoulaki

Published
2021
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18. #Springwatch #WildMorningswithChris: Engaging With Nature via Social Media and Wellbeing During the COVID-19 Lockdown

Author

Shi Xu, George Murrell, Sarah E. Golding, Beth F. T. Brockett, Birgitta Gatersleben, Caroline Scarles, Emma V. White, Cheryl Willis, and Kayleigh J. Wyles

Subjects
COVID-19, natural world, wellbeing, online engagement, Facebook, thematic analysis, Psychology, BF1-990
Abstract

It is widely understood that nature engagement benefits human wellbeing. Such benefits have been found for real as well as virtual engagements. However, little is known about the role of nature-based videos in social media on wellbeing. With COVID-19 restrictions limiting people’s direct engagement with natural environments, this study critically examined people’s reactions to nature videos posted on Facebook during the first UK COVID-19 lockdown in 2020. Data consisted of comments on videos containing highlights from the British Broadcasting Corporation’s (BBC) Springwatch 2020 television series, and from a UK television presenter and naturalist’s (Chris Packham) livestream videos, posted on Facebook from March to July, 2020. Looking at the quantitative profile of a range of videos (i.e. views, likes and shares) and a detailed analysis of the 143,265 comments using thematic analysis, three major themes were generated as: (1) engaging with nature via social media is emotionally complicated, (2) cognitive and reflective reactions are generated from social media nature engagement and (3) engagement with nature-based social media as a mechanism for coping with stress during COVID-19. These findings inform understanding of how nature-related social media content and associated commentary have supported wellbeing throughout the ongoing pandemic and their importance as a means of continued support for wellbeing.‘We feel that the injection of wildlife into people’s homes, particularly at this point, would be really valuable and uplifting’.— Chris Packham, 2020

Published
2021
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23. Rheumatic heart disease in pregnancy and neonatal outcomes: A systematic review and meta-analysis.

Author

Joshua Liaw, Betrice Walker, Leanne Hall, Susan Gorton, Andrew V White, and Clare Heal

Subjects
Medicine, Science
Abstract

PurposeAssociations between rheumatic heart disease (RHD) in pregnancy and fetal outcomes are relatively unknown. This study aimed to review rates and predictors of major adverse fetal outcomes of RHD in pregnancy.MethodsMedline (Ovid), Pubmed, EMcare, Scopus, CINAHL, Informit, and WHOICTRP databases were searched for studies that reported rates of adverse perinatal events in women with RHD during pregnancy. Outcomes included preterm birth, intra-uterine growth restriction (IUGR), low-birth weight (LBW), perinatal death and percutaneous balloon mitral valvuloplasty intervention. Meta-analysis of fetal events by the New-York Heart Association (NYHA) heart failure classification, and the Mitral-valve Area (MVA) severity score was performed with unadjusted random effects models and heterogeneity of risk ratios (RR) was assessed with the I2 statistic. Quality of evidence was evaluated using the GRADE approach. The study was registered in PROSPERO (CRD42020161529).FindingsThe search identified 5949 non-duplicate records of which 136 full-text articles were assessed for eligibility and 22 studies included, 11 studies were eligible for meta-analyses. In 3928 pregnancies, high rates of preterm birth (9.35%-42.97%), LBW (12.98%-39.70%), IUGR (6.76%-22.40%) and perinatal death (0.00%-9.41%) were reported. NYHA III/IV pre-pregnancy was associated with higher rates of preterm birth (5 studies, RR 2.86, 95%CI 1.54-5.33), and perinatal death (6 studies, RR 3.23, 1.92-5.44). Moderate /severe mitral stenosis (MS) was associated with higher rates of preterm birth (3 studies, RR 2.05, 95%CI 1.02-4.11) and IUGR (3 studies, RR 2.46, 95%CI 1.02-5.95).InterpretationRHD during pregnancy is associated with adverse fetal outcomes. Maternal NYHA III/IV and moderate/severe MS in particular may predict poor prognosis.

Published
2021
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25. Assessing Insecticide Resistance in Adult Mosquitoes: Perspectives on Current Methods

Author

Stephanie L Richards, Brian D Byrd, Michael H Reiskind, and Avian V White

Subjects
Environmental sciences, GE1-350, Public aspects of medicine, RA1-1270
Abstract

Mosquito insecticide resistance (IR) is a growing global issue that must be addressed to protect public health. Vector control programs (VCPs) should regularly monitor local mosquito populations for IR and plan control measures accordingly. In some cases, state/federal resources financially support this testing with expertise and/or training programs. Standardization of methods (eg, Centers for Disease Control and Prevention bottle bioassay, World Health Organization tube testing, dose-mortality bioassay) for monitoring IR must be prioritized. One solution is regional hubs of IR monitoring at the state or other level. Training programs on methodology and interpretation of results should be developed and routinely offered to local VCPs conducting IR testing in mosquitoes. Here, current methods for assessing mosquito IR are discussed and insights into a variety of questions from VCPs are considered. It is critical that methods for IR monitoring and data interpretation are standardized through routine training, with the goal of evidence-driven decision making to improve control of mosquitoes and mosquito-borne disease.

Published
2020
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26. GWTC-2: Compact Binary Coalescences Observed by LIGO and Virgo During the First Half of the Third Observing Run

Author

R Abbott, T D Abbott, S Abraham, F Acernese, K Ackley, A Adams, C Adams, R X Adhikari, V B Adya, C Aeldt, M Agathos, K Agatsuma, N Aggarwal, O D Aguiar, L Aiello, A Ain, P Ajith, S Akcay, G Allen, A Allocca, P A Altin, A Amato, S Anand, A Ananyeva, S B Anderson, W G Anderson, S V Angelova, S Ansoldi, J M Antelis, K Arai, M Arene, S Antier, J S Areeda, S Appert, M C Araya, N Arnaud, S M Aronson, K G Arun, Y Asali, S Ascenzi, G Ashton, S M Aston, P Astone, F Aubin, P Aufmuth, K AultONeal, C Austin, V Avendano, S Babak, F Badaracco, M K M Bader, S Bae, A M Baer, S Bagnasco, J Baird, M Ball, G Ballardin, S W Ballmer, A Bals, A Balsamo, G Baltus, S Banagiri, D Bankar, R S Bankar, J C Barayoga, C Barbieri, B C Barish, D Barker, P Barneo, S Barnum, F Barone, B Barr, L Barsotti, M Barsuglia, D Barta, J Bartlett, I Bartos, R Bassiri, A Basti, M Bawaj, J C Bayley, M Bazzan, B R Becher, B Becsy, V M Bedakihale, M Bejger, I Belahcene, D Beniwal, M G Benjamin, T F Bennett, J D Bentley, F Bergamin, B K Berger, G Bergmann, S Bernuzzi, C P L Berry, D Bersanetti, A Bertolini, J Betzwieser, R Bhandare, A V Bhandari, D Bhattacharjee, J Bidler, I A Bilenko, G Billingsley, R Birney, O Birnholtz, S Biscans, M Bischi, S Biscoveanu, A Bisht, M Bitossi, M -A Bizouard, J K Blackburn, J Blackman, C D Blair, D G Blair, R M Blair, O Blanch, F Bobba, N Bode, M Boer, Y Boetzel, G Bogaert, M Boldrini, F Bondu, E Bonilla, R Bonnand, P Booker, B A Boom, R Bork, V Boschi, S Bose, V Bossilkov, V Boudart, Y Bouanais, A Bozzi, C Bradaschia, P R Brady, A Bramley, M Branchesi, J E Brau, M Breschi, T Briant, J H Briggs, F Brighenti, A Brillet, M Brinkmann, P Brockill, A F Brooks, J Brooks, D D Brown, S Brunett, G Bruno, R Bruntz, A Buikema, T Bulik, H J Bulten, A Buonanno, R Buscicchio, D Buskulic, R L Byer, M Cabero, L Cadonati, M Caesar, G Cagnoli, C Cahillane, J Calderon Bustillo, J D Callaghan, T A Callister, E Calloni, J B Camp, M Canepa, K C Cannon, H Cao, J Cao, G Carapella, F Carbognani, M F Carney, M Carpinelli, G Carullo, T L Carver, J Casanueva Diaz, C Casentini, S Caudill, M Cavaglia, F Cavalier, R Cavalieri, G Cella, P Cerda Duran, E Cesarini, W Chaibi, K Chakravarti, C -L Chan, C Chan, K Chandra, P Chanial, S Chao, P Charlton, E A Chase, E Chassande Mottin, D Chatterjee, D Chattopadhyay, M Chaturvedi, K Chatziioannou, A Chen, H Y Chen, X Chen, Y Chen, H -P Cheng, C K Cheong, H Y Chia, F Chiadini, R Chierici, A Chincarini, A Chiummo, G Cho, H S Cho, M Cho, S Choate, N Christensen, Q Chu, S Chua, K W Chung, S Chung, G Ciani, P Ciecielag, M Cieslar, M Cifaldi, A A Ciobanu, R Ciolfi, F Cipriano, A Cirone, F Clara, E N Clark, J A Clark, L Clarke, P Clearwater, S Clesse, F Cleva, E Coccia, P -F Cohadon, D E Cohen, M Colleoni, C G Collette, C Collins, M Colpi, M Constancio Jr, L Conti, S J Cooper, P Corban, T R Corbitt, I Cordero Carrion, S Corezzi, K R Corley, N Cornish, D Corre, A Corsi, S Cortese, C A Costa, R Cotesta, M W Coughlin, S B Coughlin, J -P Coulon, S T Countryman, B Cousins, P Couvares, P B Covas, D M Coward, M J Cowart, D C Coyne, R Coyne, J D E Creighton, T D Creighton, M Croquette, S G Crowder, J R Cudell, T J Cullen, A Cumming, R Cummings, L Cunningham, E Cuoco, M Curylo, T Dal Canton, G Dalya, A Dana, L M DaneshgaranBajastani, B DAngelo, B Danila, S L Danilishin, S DAntonio, K Danzmann, C DarsowFromm, A Dasgupta, L E H Datrier, V Dattilo, I Dave, M Davier, G S Davies, D Davis, E J Daw, R Dean, D DeBra, M Deenadayalan, J Degallaix, M De Laurentis, S Deleglise, V Del Favero, F De Lillo, N De Lillo, W Del Pozzo, L M DeMarchi, F De Matteis, V DEmilio, N Demos, T Denker, T Dent, A Depasse, R De Pietri, R De Rosa, C De Rossi, R DeSalvo, O de Varona, S Dhurandhar, M C Diaz, M Diaz Ortiz Jr, N A Didio, T Dietrich, L Di Fiore, C DiFronzo, C Di Giorgio, F Di Giovanni, M Di Giovanni, T Di Girolamo, A Di Lieto, B Ding, S Di Pace, I Di Palma, F Di Renzo, A K Divakarla, A Dmitriev, Z Doctor, L DOnofrio, F Donovan, K L Dooley, S Doravari, I Dorrington, T P Downes, M Drago, J C Driggers, Z Du, J -G Ducoin, P Dupej, O Durante, D DUrso, P -A Duverne, S E Dwyer, P J Easter, G Eddolls, B Edelman, T B Edo, O Edy, A Effler, J Eichholz, S S Eikenberry, M Eisenmann, R A Eisenstein, A Ejlli, L Errico, R C Essick, H Estelles, D Estevez, Z B Etienne, T Etzel, M Evans, T M Evans, B E Ewing, V Fafone, H Fair, S Fairhurst, X Fan, A M Farah, S Farinon, B Farr, W M Farr, E J Fauchon Jones, M Favata, M Fays, M Fazio, J Feicht, M M Fejer, F Feng, E Fenyvesi, D L Ferguson, A Fernandez Galiana, I Ferrante, T A Ferreira, F Fidecaro, P Figura, I Fiori, D Fiorucci, M Fishbach, R P Fisher, J M Fishner, R Fittipaldi, M Fitz Axen, V Fiumara, R Flaminio, E Floden, E Flynn, H Fong, J A Font, P W F Forsyth, J -D Fournier, S Frasca, F Frasconi, Z Frei, A Freise, R Frey, V Frey, P Fritschel, V V Frolov, G G Fronze, P Fulda, M Fyffe, H A Gabbard, B U Gadre, S M Gaebel, J R Gair, J Gais, S Galaudage, R Gamba, D Ganapathy, A Ganguly, S G Gaonkar, B Garaventa, C Garcia Quiros, F Garufi, B Gateley, S Gaudio, V Gayathri, G Gemme, A Gennai, D George, J George, R N George, L Gergely, S Ghonge, Abhirup Ghosh, Archisman Ghosh, S Ghosh, B Giacomazzo, L Giacoppo, J A Giaime, K D Giardina, D R Gibson, C Gier, K Gill, P Giri, J Glanzer, A E Gleckl, P Godwin, E Goetz, R Goetz, N Gohlke, B Goncharov, G Gonzalez, A Gopakumar, S E Gossan, M Gosselin, R Gouaty, B Grace, A Grado, M Granata, V Granata, A Grant, S Gras, P Grassia, C Gray, R Gray, G Greco, A C Green, R Green, E M Gretarsson, H L Griggs, G Grignani, A Grimaldi, E Grimes, S J Grimm, H Grote, S Grunewald, P Gruning, J G Guerrero, G M Guidi, A R Guimaraes, G Guixe, H K Gulati, Y Guo, Anchal Gupta, Anuradha Gupta, P Gupta, E K Gustafson, R Gustafson, F Guzman, L Haegel, O Halim, E D Hall, E Z Hamilton, G Hammond, M Haney, M M Hanke, J Hanks, C Hanna, M D Hannam, O A Hannuksela, O Hannuksela, H Hansen, T J Hansen, J Hanson, T Harder, T Hardwick, K Haris, J Harms, G M Harry, I W Harry, D Hartwig, R K Hasskew, C -J Haster, K Haughian, F J Hayes, J Healy, A Heidmann, M C Heintze, J Heinze, J Heinzel, H Heitmann, F Hellman, P Hello, A F Helmling Cornell, G Hemming, M Hendry, I S Heng, E Hennes, J Hennig, M H Hennig, F Hernandez Vivanco, M Heurs, S Hild, P Hill, A S Hines, S Hochheim, E Hofgard, D Hofman, J N Hohmann, A M Holgado, N A Holland, I J Hollows, Z J Holmes, K Holt, D E Holz, P Hopkins, C Horst, J Hough, E J Howell, C G Hoy, D Hoyland, Y Huang, M T Hubner, A D Huddart, E A Huerta, B Hughey, V Hui, S Husa, S H Huttner, B M Hutzler, R Huxford, T Huynh-Dinh, B Idzkowski, A Iess, S Imperato, H Inchauspe, C Ingram, G Intini, M Isi, B R Iyer, V JaberianHamedan, T Jacqmin, S J Jadhav, S P Jadhav, A L James, K Jani, K Janssens, N N Janthalur, P Jaranowski, D Jariwala, R Jaume, A C Jenkins, M Jeunon, J Jiang, G R Johns, N K Johnson McDaniel, A W Jones, D I Jones, J D Jones, P Jones, R Jones, R J G Jonker, L Ju, J Junker, C V Kalaghatgi, V Kalogera, B Kamai, S Kandhasamy, G Kang, J B Kanner, S J Kapadia, D P Kapasi, C Karathanasis, S Karki, R Kashyap, M Kasprzack, W Kastaun, S Katsanevas, E Katsavounidis, W Katzman, K Kawabe, F Kefelian, D Keitel, J S Key, S Khadka, F Y Khalili, I Khan, S Khan, E A Khazanov, N Khetan, M Khursheed, N Kijbunchoo, C Kim, G J Kim, J C Kim, K Kim, W S Kim, Y -M Kim, C Kimball, P J King, M Kinley Hanlon, R Kirchho, J S Kissel, L Kleybolte, S Klimenko, T D Knowles, E Knyazev, P Koch, S M Koehlenbeck, G Koekoek, S Koley, M Kolstein, K Komori, V Kondrashov, A Kontos, N Koper, M Korobko, W Z Korth, M Kovalam, D B Kozak, C Kramer, V Kringel, N V Krishnendu, A Krolak, G Kuehn, A Kumar, P Kumar, Rahul Kumar, Rakesh Kumar, K Kuns, S Kwang, B D Lackey, D Laghi, E Lalande, T L Lam, A Lamberts, M Landry, B B Lane, R N Lang, J Lange, B Lantz, R K Lanza, I La Rosa, A Lartaux Vollard, P D Lasky, M Laxen, A Lazzarini, C Lazzaro, P Leaci, S Leavey, Y K Lecoeuche, H M Lee, H W Lee, J Lee, K Lee, J Lehmann, E Leon, N Leroy, N Letendre, Y Levin, A Li, J Li, K J L Li, T G F Li, X Li, F Linde, S D Linker, J N Linley, T B Littenberg, J Liu, X Liu, M Llorens Monteagudo, R K L Lo, A Lockwood, L T London, A Longo, M Lorenzini, V Loriette, M Lormand, G Losurdo, J D Lough, C O Lousto, G Lovelace, H Luck, D Lumaca, A P Lundgren, Y Ma, R Macas, M MacInnis, D M Macleod, I A O MacMillan, A Macquet, I Magana Hernandez, F Magana Sandoval, C Magazzu, R M Magee, E Majorana, I Maksimovic, S Maliakal, A Malik, N Man, V Mandic, V Mangano, G L Mansell, M Manske, M Mantovani, M Mapelli, F Marchesoni, F Marion, S Marka, Z Marka, C Markakis, A S Markosyan, A Markowitz, E Maros, A Marquina, S Marsat, F Martelli, I W Martin, R M Martin, M Martinez, V Martinez, D V Martynov, H Masalehdan, K Mason, E Massera, A Masserot, T J Massinger, M Masso Reid, S Mastrogiovanni, A Matas, M Mateu Lucena, F Matichard, M Matiushechkina, N Mavalvala, E Maynard, J J McCann, R McCarthy, D E McClelland, S McCormick, L McCuller, S C McGuire, C McIsaac, J McIver, D J McManus, T McRae, S T McWilliams, D Meacher, G D Meadors, M Mehmet, A K Mehta, A Melatos, D A Melchor, G Mendell, A Menendez Vazquez, R A Mercer, L Mereni, K Merfeld, E L Merilh, J D Merritt, M Merzougui, S Meshkov, C Messenger, C Messick, R Metzdor, P M Meyers, F Meylahn, A Mhaske, A Miani, H Miao, I Michaloliakos, C Michel, H Middleton, L Milano, A L Miller, M Millhouse, J C Mills, E Milotti, M C Milovich Go, O Minazzoli, Y Minenkov, Ll M Mir, A Mishkin, C Mishra, T Mistry, S Mitra, V P Mitrofanov, G Mitselmakher, R Mittleman, G Mo, K Mogushi, S R P Mohapatra, S R Mohite, I Molina, M Molina Ruiz, M Mondin, M Montani, C J Moore, D Moraru, F Morawski, G Moreno, S Morisaki, B Mours, C M Mow Lowry, S Mozzon, F Muciaccia, Arunava Mukherjee, D Mukherjee, Soma Mukherjee, Subroto Mukherjee, N Mukund, A Mullavey, J Munch, E A Muniz, P G Murray, S L Nadji, A Nagar, I Nardecchia, L Naticchioni, R K Nayak, B F Neil, J Neilson, G Nelemans, T J N Nelson, M Nery, A Neunzert, A H Nitz, K Y Ng, S Ng, C Nguyen, P Nguyen, T Nguyen, S A Nichols, S Nissanke, F Nocera, M Noh, C North, D Nothard, L K Nuttall, J Oberling, B D O Brien, J O Dell, G Oganesyan, G H Ogin, J J Oh, S H Oh, F Ohme, H Ohta, M A Okada, C Olivetto, P Oppermann, R J Oram, B O Reilly, R G Ormiston, L F Ortega, R O Shaughnessy, S Ossokine, C Osthelder, D J Ottaway, H Overmier, B J Owen, A E Pace, G Pagano, M A Page, G Pagliaroli, A Pai, S A Pai, J R Palamos, O Palashov, C Palomba, H Pan, P K Panda, T H Pang, C Pankow, F Pannarale, B C Pant, F Paoletti, A Paoli, A Paolone, W Parker, D Pascucci, A Pasqualetti, R Passaquieti, D Passuello, M Patel, B Patricelli, E Payne, T C Pechsiri, M Pedraza, M Pegoraro, A Pele, S Penn, A Perego, C J Perez, C Perigois, A Perreca, S Perries, J Petermann, D Petterson, H P Pfeiffer, K A Pham, K S Phukon, O J Piccinni, M Pichot, M Piendibene, F Piergiovanni, L Pierini, V Pierro, G Pillant, F Pilo, L Pinard, I M Pinto, K Piotrzkowski, M Pirello, M Pitkin, E Placidi, W Plastino, C Pluchar, R Poggiani, E Polini, D Y T Pong, S Ponrathnam, P Popolizio, E K Porter, A Poverman, J Powell, M Pracchia, K Prasai, R Prasanna, G Pratten, T Prestegard, M Principe, G A Prodi, L Prokhorov, P Prosposito, L Prudenzi, A Puecher, M Punturo, F Puosi, P Puppo, M Purrer, H Qi, V Quetschke, P J Quinonez, R Quitzow James, F J Raab, G Raaijmakers, H Radkins, N Radulesco, P Raffai, H Rafferty, S X Rail, S Raja, C Rajan, B Rajbhandari, M Rakhmanov, K E Ramirez, T D Ramirez, A Ramos Buades, J Rana, K Rao, P Rapagnani, U D Rapol, B Ratto, V Raymond, M Razzano, J Read, T Regimbau, L Rei, S Reid, D H Reitze, P Rettegno, F Ricci, C J Richardson, J W Richardson, L Richardson, P M Ricker, G Riemenschneider, K Riles, M Rizzo, N A Robertson, A Rocchi, J A Rocha, S Rodriguez, R D Rodriguez Soto, L Rolland, J G Rollins, V J Roma, M Romanelli, F Robinet, R Romano, C L Romel, A Romero, I M Romero Shaw, J H Romie, S Ronchini, C A Rose, D Rose, K Rose, M J B Rosell, D Rosinska, S G Rosofsky, M P Ross, S Rowan, S J Rowlinson, Santosh Roy, Soumen Roy, P Ruggi, K Ryan, S Sachdev, T Sadecki, J Sadiq, M Sakellariadou, O S Salafia, L Salconi, M Saleem, A Samajdar, E J Sanchez, J H Sanchez, L E Sanchez, N Sanchis Gual, J R Sanders, L Sandles, K A Santiago, E Santos, T R Saravanan, N Sarin, B Sassolas, B S Sathyaprakash, O Sauter, R L Savage, V Savant, D Sawant, S Sayah, D Schaetzl, P Schale, M Scheel, J Scheuer, A Schindler Tyka, P Schmidt, R Schnabel, R M S Schofield, A Schonbeck, E Schreiber, B W Schulte, B F Schutz, O Schwarm, E Schwartz, J Scott, S M Scott, M Seglar Arroyo, E Seidel, D Sellers, A S Sengupta, N Sennett, D Sentenac, V Sequino, A Sergeev, Y Setyawati, T Shaffer, M S Shahriar, S Shariffi, A Sharma, P Sharma, P Shawhan, H Shen, M Shikauchi, R Shink, D H Shoemaker, D M Shoemaker, K Shukla, S ShyamSundar, M Sieniawska, D Sigg, L P Singer, D Singh, N Singh, A Singha, A Singhal, A M Sintes, V Sipala, V Skliris, B J J Slagmolen, T J Slaven Blair, J Smetana, J R Smith, R J E Smith, S N Somala, E J Son, K Soni, S Soni, B Sorazu, V Sordini, F Sorrentino, N Sorrentino, R Soulard, T Souradeep, E Sowell, A P Spencer, M Spera, A K Srivastava, V Srivastava, K Staats, C Stachie, D A Steer, J Steinho, M Steinke, J Steinlechner, S Steinlechner, D Steinmeyer, S P Stevenson, G Stolle McAllister, D J Stops, M Stover, K A Strain, G Stratta, A Strunk, R Sturani, A L Stuver, J Sudbeck, S Sudhagar, V Sudhir, H G Suh, T Z Summerscales, H Sun, L Sun, S Sunil, A Sur, J Suresh, P J Sutton, B L Swinkels, M J Szczepanczyk, M Tacca, S C Tait, C Talbot, A J Tanasijczuk, D B Tanner, D Tao, A Tapia, E N Tapia San Martin, J D Tasson, R Taylor, R Tenorio, L Terkowski, M P Thirugnanasambandam, L M Thomas, M Thomas, P Thomas, J E Thompson, S R Thondapu, K A Thorne, E Thrane, Shubhanshu Tiwari, Srishti Tiwari, V Tiwari, K Toland, A E Tolley, M Tonelli, Z Tornasi, A Torres Forne, C I Torrie, I Tosta e Melo, D Toyra, A T Tran, A Trapananti, F Travasso, G Traylor, M C Tringali, A Tripathee, A Trovato, R J Trudeau, D S Tsai, K W Tsang, M Tse, R Tso, L Tsukada, D Tsuna, T Tsutsui, M Turconi, A S Ubhi, R P Udall, K Ueno, D Ugolini, C S Unnikrishnan, A L Urban, S A Usman, A C Utina, H Vahlbruch, G Vajente, A Vajpeyi, G Valdes, M Valentini, V Valsan, N van Bakel, M van Beuzekom, J F J van den Brand, C Van Den Broeck, D C Vander Hyde, L van der Schaaf, J V van Heijningen, M Vardaro, A F Vargas, V Varma, S Vass, M Vasuth, A Vecchio, G Vedovato, J Veitch, P J Veitch, K Venkateswara, J Venneberg, G Venugopalan, D Verkindt, Y Verma, D Veske, F Vetrano, A Vicere, A D Viets, A Vijaykumar, V Villa Ortega, J -Y Vinet, S Vitale, T Vo, H Vocca, C Vorvick, S P Vyatchanin, A R Wade, L E Wade, M Wade, R C Walet, M Walker, G S Wallace, L Wallace, S Walsh, J Z Wang, S Wang, W H Wang, Y F Wang, R L Ward, J Warner, M Was, N Y Washington, J Watchi, B Weaver, L Wei, M Weinert, A J Weinstein, R Weiss, F Wellmann, L Wen, P Wessels, J W Westhouse, K Wette, J T Whelan, D D White, L V White, B F Whiting, C Whittle, D M Wilken, D Williams, M J Williams, A R Williamson, J L Willis, B Willke, D J Wilson, M H Wimmer, W Winkler, C C Wipf, G Woan, J Woehler, J K Wofford, I C F Wong, J Wrangel, J L Wright, D S Wu, D M Wysocki, L Xiao, H Yamamoto, L Yang, Y Yang, Z Yang, M J Yap, D W Yeeles, A Yoon, Hang Yu, Haocun Yu, S H R Yuen, A Zadrozny, M Zanolin, T Zelenova, J -P Zendri, M Zevin, J Zhang, L Zhang, R Zhang, T Zhang, C Zhao, G Zhao, Y Zheng, M Zhou, Z Zhou, X J Zhu, A B Zimmerman, Y Zlochower, M E Zucker, and J Zweizig

Subjects
Astronomy
Abstract

We report on gravitational wave discoveries from compact binary coalescences detected by Advanced LIGO and Advanced Virgo in the first half of the third observing run (O3a) between 1 April 2019 15:00 UTC and 1 October 2019 15:00 UTC. By imposing a false-alarm-rate threshold of two per year in each of the four search pipelines that constitute our search, we present 39 candidate gravitational wave events. At this threshold, we expect a contamination fraction of less than 10%. Of these, 26 candidate events were reported previously in near real-time through GCN Notices and Circulars; 13 are reported here for the first time. The catalog contains events whose sources are black hole binary mergers up to a redshift of ~ 0.8, as well as events whose components could not be unambiguously identified as black holes or neutron stars. For the latter group, we are unable to determine the nature based on estimates of the component masses and spins from gravitational wave data alone. The range of candidate event masses which are unambiguously identified as binary black holes (both objects ≥ 3 M⨀) is increased compared to GWTC-1, with total masses from ∼ 14M⨀ for GW190924 021846 to ∼ 150M⨀ for GW190521. For the first time, this catalog includes binary systems with significantly asymmetric mass ratios, which had not been observed in data taken before April 2019. We also find that 11 of the 39 events detected since April 2019 have positive effective inspiral spins under our default prior (at 90% credibility), while none exhibit negative effective inspiral spin. Given the increased sensitivity of Advanced LIGO and Advanced Virgo, the detection of 39 candidate events in ∼26 weeks of data (∼1.5 per week) is consistent with GWTC-1.

Published
2021
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27. Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing

Author

Jun Ishihara, Ako Ishihara, Kazuto Fukunaga, Koichi Sasaki, Michael J. V. White, Priscilla S. Briquez, and Jeffrey A. Hubbell

Subjects
Science
Abstract

Laminins are important regulators of epidermal wound healing. Here, the authors show that laminins bind to multiple growth factors via their heparin-binding domains, and that incorporation of these domains into fibrin matrices increases growth factor retention, promoting wound healing in type 2 diabetic mouse models.

Published
2018
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28. Six-step total syntheses of (−)-galanthamine and (−)

Author

Nan Hu, Yu-Tao He, Ping Lan, Martin G. Banwell, and Lorenzo V. White

Subjects
General Chemistry
Abstract

The Amaryllidaceae alkaloid (−)-galanthamine (1) is a reversible, competitive acetylcholinesterase inhibitor deployed clinically to treat the dementia associated with Alzheimer’s disease. Here, we describe a six-step synthesis of this natural product from simple, readily accessible starting materials. Enantioselective 1,2-reduction, Mitsunobu coupling, Heck cyclization and diastereoselective allylic oxidation reactions are used in our approach, which provides the shortest synthetic route to compound 1 reported to date. A simple modification to the closing stages of the sequence allows equally facile access to (−)-N-norgalanthamine (2), a compound with a range of distinctive biological properties. The concise and operationally simple synthetic protocols reported here could obviate the need to manipulate naturally sourced galanthamine in the pursuit of analogues required for pharmacological studies.

Published
2022
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31. Viewing Classical Radio Galaxies with the Upgraded GMRT and MeerKAT—A Progress Report

Author

Dharam V. Lal, Portia Legodi, Bernie Fanaroff, Tiziana Venturi, Oleg M. Smirnov, Marco Bondi, Kshitij Thorat, Landman H. Bester, Gyula I. G. Józsa, Dane Kleiner, Francesca Loi, Sphesihle Makhathini, and Sarah V. White

Subjects
galaxies, active–galaxies, jets–galaxies, nuclei–galaxies, polarisation–galaxies, structure–radio continuum, Astronomy, QB1-991
Abstract

We present a progress report of a study of FR I and FR II radio galaxies. Several new morphological features in the radio emission are now revealed using the high (μJy) sensitivity reached in the range 550–1712 MHz, more than a factor of three, at the high (∼4″−7″) angular resolution with the upgraded Giant Metrewave Radio Telescope (uGMRT) and MeerKAT. Therefore, the aim of this study is to understand if we need to revise our current classification scheme for classical radio galaxies. In order to address our goals, we have carefully constructed a sample of 14 (6 FR I, 6 FR II and 2 FR 0) radio galaxies. The uGMRT and MeerKAT images of our four target sources revealed a wealth of morphological details, e.g., filamentary structure in the emission from the lobes, misalignments, radio emission beyond the hot-spots in three sources, etc.; see Fanaroff et al. (2021). Here, we present preliminary results for two more radio galaxies from our sample using uGMRT, in the light of the local environment. Finally, we are awaiting uGMRT and MeerKAT observations of remaining sample sources. Our results show that for the radio galaxies in this study, the morphological classification scheme for the classical FR I/FR II radio galaxies still holds, even with the improved imaging capabilities of the uGMRT and MeerKAT. Furthermore, we need to be cautious when using automated procedures for classification schemes, e.g., in surveys (with poorer sensitivities and angular resolutions) because of the rich morphological details that are shown in our uGMRT and MeerKAT images.

Published
2021
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33. Practical, Multigram Preparation of Synthetically Useful, Enantiomerically Pure Building-Blocks from Quinic Acid

Author

Lorenzo V. White, Martin G. Banwell, Shen Tan, and Ping Lan

Subjects
Biomaterials, Materials Science (miscellaneous), Organic Chemistry, Catalysis
Abstract

The naturally abundant, enantiomerically pure cyclitol quinic acid has been converted into a synthetically useful enone in nearly quantitative yield using the operationally straightforward and reproducible protocols reported herein. The latter compound, which was obtained in multigram quantities, engages in a diastereoselective 1,2-addition reaction with a hydrazone-based nucleophile. Furthermore, a readily derived α-iodoenone participates in both cross-coupling and α,β-annulation reactions. The results reported here emphasize that the now practically accessible cyclohexenones are useful, enantiomerically pure building blocks for organic synthesis.

Published
2022
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34. A Seven-Step Total Synthesis of (–)-Thebaine

Author

Lorenzo V. White, Martin G. Banwell, Shen Tan, Yu-Tao He, and Ping Lan

Subjects
Organic Chemistry, Catalysis
Abstract

The morphinan alkaloid (–)-thebaine is an industrially important chemical intermediate deployed in the semi-synthesis of various opioid medicines. Here, a seven-step total synthesis of this natural product is reported from simple, commercially available starting materials. The pivotal aryl allyl ether substrate, which is obtained through successive Suzuki-Miyaura cross-coupling and Mitsunobu substitution reactions, was engaged in a double-Heck cyclization sequence. The tetracyclic product of these processes was subjected to a photochemical hydroamination reaction that generated a N-Boc piperidine derivative embodying the full pentacyclic morphinan framework. Over a further three simple steps, this last compound was converted into (–)-thebaine.

Published
2022
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36. Thermostat wars? The roles of gender and thermal comfort negotiations in household energy use behavior.

Author

Nicole D Sintov, Lee V White, and Hugh Walpole

Subjects
Medicine, Science
Abstract

Although advanced thermostat technologies offer energy efficiency potential, these devices alone do not guarantee savings. Household occupants often deviate from thermostat programs, perhaps due to differing thermal comfort preferences, which are strong drivers of residential energy use and vary across genders. This study aims to develop an initial typology of interpersonal interactions around thermal comfort, explore the role of gender in such interactions, and examine the impacts of interactions on thermostat adjustments. Using n = 1568 diary observations collected from 112 participants, we identify three interaction types: conflicts, compromises, and agreements. Fixed effects analyses find that women are marginally more likely to report engaging in conflicts, whereas men are significantly more likely to report engaging in agreements and compromises, both of which are associated with greater likelihood of adjusting thermostats within a given day. This work represents an early step in investigating the multiply determined nature of household energy decisions.

Published
2019
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37. Clonally expanded alpha-chain T-cell receptor (TCR) transcripts are present in aneurysmal lesions of patients with Abdominal Aortic Aneurysm (AAA).

Author

Song Lu, John V White, Raquel I Judy, Lisa L Merritt, Wan Lu Lin, Xiaoying Zhang, Charalambos Solomides, Ifeyinwa Nwaneshiudu, John Gaughan, Dimitri S Monos, Emilia L Oleszak, and Chris D Platsoucas

Subjects
Medicine, Science
Abstract

Abdominal aortic aneurysm (AAA) is a life-threatening immunological disease responsible for 1 to 2% of all deaths in 65 year old or older individuals. Although mononuclear cell infiltrates have been demonstrated in AAA lesions and autoimmunity may be responsible for the initiation and account for the propagation of the disease, the information available about the pathogenesis of AAA is limited. To examine whether AAA lesions from patients with AAA contain clonally expanded α-chain TCR transcripts, we amplified by the non-palindromic adaptor-PCR (NPA-PCR)/Vα-specific PCR and/or the Vα-specific PCR these α-chain TCR transcripts. The amplified transcripts were cloned and sequenced. Substantial proportions of identical α-chain TCR transcripts were identified in AAA lesions of 4 of 5 patients, demonstrating that clonally expanded T cells are present in these AAA lesions. These results were statistically significant by the bimodal distribution. Three of 5 of these patients were typed by DNA-based HLA-typing and all three expressed DRB1 alleles containing the DRβGln70 amino acid residue that has been demonstrated to be associated with AAA. All three patients exhibited clonally expanded T cells in AAA lesions. Four of the 5 patients with AAA who exhibited clonal expansions of α-chain TCR transcripts, also exhibited clonal expansions of β-chain TCR transcripts in AAA lesions, as we have demonstrated previously (J Immunol 192:4897, 2014). αβ TCR-expressing T cells infiltrating AAA lesions contain T-cell clones which have undergone proliferation and clonal expansion in vivo in response to as yet unidentified specific antigens that may be self or nonself. These results provide additional evidence supporting the hypothesis that AAA is a specific antigen-driven T-cell autoimmune disease.

Published
2019
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38. Mid-upper arm circumference predicts death in adult patients admitted to a TB ward in the Philippines: A prospective cohort study.

Author

Nathaniel Lee, Laura V White, Flora P Marin, Naomi R Saludar, Marietta B Solante, Rosario J C Tactacan-Abrenica, Rugaiya W Calapis, Motoi Suzuki, Nobuo Saito, Koya Ariyoshi, Christopher M Parry, Tansy Edwards, and Sharon E Cox

Subjects
Medicine, Science
Abstract

BackgroundThe Philippines is ranked 3rd globally for tuberculosis incidence (554/100,000 population). The tuberculosis ward at San Lazaro Hospital, Manila receives 1,800-2,000 admissions of acutely unwell patients per year with high mortality. Objectives of this prospective cohort study were to quantify the association of under-nutrition (primary) and diabetes (secondary) with inpatient mortality occurring between 3-28 days of hospital admission in patients with suspected or previously diagnosed TB.Methods and resultsWe enrolled 360 adults (≥18 years); 348 were eligible for the primary analysis (alive on day 3). Clinical, laboratory, anthropometric and enhanced tuberculosis diagnostic data were collected at admission with telephone tracing for mortality up to 6 months post-discharge. In the primary analysis population (mean age 45 years, SD = 15.0 years, 70% male), 58 (16.7%) deaths occurred between day 3-28 of admission; 70 (20.1%) between day 3 and discharge and documented total post-day 3 mortality including follow-up was 96 (27.6%). In those in whom it could be assessed, body mass index (BMI) ranged from 11.2-30.6 kg/m2 and 141/303 (46.5%) had moderate/severe undernutrition (BMIConclusionThis research supports the use of mid-upper arm circumference for triaging acutely unwell patients and the design and testing of nutrition-based interventions to improve patient outcomes.

Published
2019
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39. Performance of alternative measures to body mass index in the assessment of moderate and severe under-nutrition among acutely unwell patients hospitalized in a TB ward in the Philippines: A cross-sectional study.

Author

Laura V White, Nathaniel Lee, Flora P Marin, Naomi R Saludar, Tansy Edwards, and Sharon E Cox

Subjects
Medicine, Science
Abstract

Body mass index (BMI) kg/m2 is a key screening tool for under-nutrition in adults, but difficult to obtain in immobile or unwell patients, particuarly in low resource settings, due to inability to accurately measure both weight and height. Mid-upper arm circumference (MUAC) is used to assess under-nutrition in children under 5 years but no standardised cut-off values exist for adults. In a cohort of adult Filipino patients admitted to a tuberculosis ward we assessed (i) cut-offs for MUAC to predict moderate under-nutrition (BMI

Published
2019
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40. What Impact Does Participation in a Communication Skills Training Program Have on Health Professionals’ Communication Behaviors: Findings from a Qualitative Study

Author

V. White, M. Chiswell, E. Webber, P. Martin, and A. Piper

Subjects
Oncology, Public Health, Environmental and Occupational Health
Abstract

Communication skills training can enhance health professionals’ knowledge and repertoire of effective communication practices. This paper describes the conceptual model underlying a 3-day retreat communication skills training program, methods used for training, and participant perception of outcomes from the training using qualitative interviews. Repeated qualitative telephone interviews (approximately 6 months apart) with participants of a 3-day Clinical Consultation Skills Retreat. Fourteen participants (70% response, 57% doctors) took part at Time 1, with 12 participating at Time 2. Semi-structured interviews were recorded and transcribed, and directional content analysis was conducted to assess themes in areas of key learnings, implementation of skills, and barriers. The training was received very positively with participants valuing the small group learning, role play, and facilitator skills. Key learnings were grouped into two themes: (i) tips and strategies to use in clinical practice and (ii) communication frameworks/methods, with the second theme reflecting an awareness of different communication styles. Most participants had tried to implement their new skills, with implementation reported as a more deliberate activity at T1 than at T2. Those implementing the new skills noted more open conversations with patients. Practical barriers of lack of time and expectations of others were mentioned more often at T2. A 3-day retreat-based communication training program was positively received and had a positive impact on the use of new communication skills. While further work is needed to determine whether effects of training are evidenced in objective clinical behaviors, the positive longer-term benefits found suggest this work would be worthwhile.

Published
2023
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44. The Chemical Synthesis of the Crinine and Haemanthamine Alkaloids: Biologically Active and Enantiomerically-Related Systems that Serve as Vehicles for Showcasing New Methodologies for Molecular Assembly

Author

Nan Hu, Lorenzo V. White, Ping Lan, and Martin G. Banwell

Subjects
alkaloid, crinine, haemanthamine, Organic chemistry, QD241-441
Abstract

The title alkaloids, often referred to collectively as crinines, are a prominent group of structurally distinct natural products with additional members being reported on a regular basis. As such, and because of their often notable biological properties, they have attracted attention as synthetic targets since the mid-1950s. Such efforts continue unabated and more recent studies on these alkaloids have focused on using them as vehicles for showcasing the utility of new synthetic methods. This review provides a comprehensive survey of the nearly seventy-year history of these synthetic endeavors.

Published
2021
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45. Powerful radio sources in the southern sky: I. optical identifications

Author

F. Massaro, S. V. White, A. García-Pérez, A. Jimenez-Gallardo, A. Capetti, C. C. Cheung, W. R. Forman, C. Mazzucchelli, A. Paggi, N. P. H. Nesvadba, J. P. Madrid, I. Andruchow, S. Cellone, H. A. Peña-Herazo, R. Grossová, B. Balmaverde, E. Sani, V. Chavushyan, R. P. Kraft, V. Reynaldi, and C. Leto

Subjects
Ciencias Astronómicas, Extragalactic radio sources, Space and Planetary Science, Astronomy and Astrophysics
Abstract

Since the early sixties, our view of radio galaxies and quasars has been drastically shaped by discoveries made thanks to observations of radio sources listed in the Third Cambridge Catalog and its revised version (3CR). However, the largest fraction of data collected to date on 3CR sources was performed with relatively old instruments, rarely repeated and/or updated. Importantly, the 3CR contains only objects located in the Northern Hemisphere, thus having limited access to new and innovative astronomical facilities. To mitigate these limitations, we present a new catalog of powerful radio sources visible from the Southern Hemisphere, extracted from the GLEAM 4 Jy (G4Jy) catalog and based on equivalent selection criteria as the 3CR. This new catalog, named G4Jy- 3CRE, where the E stands for “equivalent,” lists a total of 264 sources at decl. below −5° and with 9 Jy limiting sensitivity at ∼178 MHz. We explored archival radio maps obtained with different surveys and compared them with optical images available in the Pan-STARRS, DES, and DSS databases to search for optical counterparts of their radio cores. We compared mid-infrared counterparts, originally associated in the G4Jy, with the optical ones identified here, and we present results of a vast literature search carried out to collect redshift estimates for all G4Jy-3CRE sources resulting in a total of 145 reliable z measurements., Instituto Argentino de Radioastronomía, Instituto de Astrofísica de La Plata

Published
2023

49. Assessment of barrier treatments impacting Aedes albopictus (diptera: culicidae) using lambda-cyhalothrin and pyriproxyfen in a suburban neighborhood in Eastern North Carolina, 2018

Author

Avian V. White, Heidi Knecht, and Stephanie L. Richards

Subjects
Health, Toxicology and Mutagenesis, Public Health, Environmental and Occupational Health, General Medicine, Pollution
Abstract

Pyrethroids are commonly used in barrier treatments but less is known about how mosquitoes are affected by the simultaneous application of an insect growth regulator (i.e., pyriproxyfen) used in barrier treatments. This field study, conducted from May 14 – October 16, 2018, evaluated the effect of lambda-cyhalothrin (pyrethroid adulticide) and pyriproxyfen on the reproduction (measured by fecundity and adult emergence) and abundance of Aedes albopictus. Nine properties were treated with Demand®CS 0.06% + Archer® 0.010% (every 60 days) and three control properties received no treatment (N=12 total properties). No significant (P>0.05) differences were observed between abundance of Ae. albopictus in treatment compared to control groups. However, significant differences were observed in abundance of Ae. albopictus adults between weeks at both control (P = 0.003) and treatment (P < 0.0001) properties. Results from our research show that continued studies are needed to determine the efficacy of barrier treatments for this species.

Published
2023
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50. GWTC-1: A Gravitational-Wave Transient Catalog of Compact Binary Mergers Observedby LIGO and Virgo During the First and Second Observing Runs

Author

Jordan B Camp, B. P. Abbott, R. Abbott, T. D. Abbott, S. Abraham, F. Acernese, K. Ackley, C. Adams, R. X. Adhikari, V. B. Adya, C. Affeldt, M. Agathos, K. Agatsuma, N. Aggarwal, O. D. Aguiar, L. Aiello, A. Ain, P. Ajith, G. Allen, A. Allocca, M. A. Aloy, P. A. Altin, A. Amato, A. Ananyeva, S. B. Anderson, W. G. Anderson, S. V. Angelova, S. Antier, S. Appert, K. Arai, M. C. Araya, J. S. Areeda, M. Arene, N. Arnaud, K. G. Arun, S. Ascenzi, G. Ashton, S. M. Aston, P. Astone, F. Aubin, P. Aufmuth, K. AultONeal, C. Austin, V. Avendano, A. Avila-Alvarez, S. Babak, P. Bacon, F. Badaracco, M. K. M. Bader, S. Bae, P. T. Baker, F. Baldaccini, G. Ballardin, S. W. Ballmer, S. Banagiri, J. C. Barayoga, S. E. Barclay, B. C. Barish, D. Barker, K. Barkett, S. Barnum, F. Barone, B. Barr, L. Barsotti, M. Barsuglia, D. Barta, J. Bartlett, I. Bartos, R. Bassiri, A. Basti, M. Bawaj, J. C. Bayley, M. Bazzan, B. Becsy53M. Bejger, I. Belahcene, A. S. Bell, D. Beniwal, B. K. Berger, G. Bergmann, S. Bernuzzi, J. J. Bero, C. P. L. Berry, D. Bersanetti, A. Bertolini, J. Betzwieser, R. Bhandare, J. Bidler, I. A. Bilenko, S. A. Bilgili, G. Billingsley, J. Birch, R. Birney, O. Birnholtz, S. Biscans, S. Biscoveanu, A. Bisht, M. Bitossi, M. A. Bizouard, J. K. Blackburn, J. Blackman, C. D. Blair, D. G. Blair, R. M. Blair, S. Bloemen, N. Bode, M. Boer, Y. Boetzel, G. Bogaert, F. Bondu, E. Bonilla, R. Bonnand, P. Booker, B. A. Boom, C. D. Booth, R. Bork, V. Boschi, S. Bose, K. Bossie, V. Bossilkov, J. Bosveld, Y. Bouffanais, A. Bozzi, C. Bradaschia, P. R. Brady, A. Bramley, M. Branchesi, J. E. Brau, T. Briant, J. H. Briggs, F. Brighenti, A. Brillet, M. Brinkmann, V. Brisson, P. Brockill, A. F. Brooks, D. D. Brown, S. Brunett, A. Buikema, T. Bulik, H. J. Bulten, A. Buonanno, D. Buskulic, M. J. Bustamante Rosell, C. Buy, R. L. Byer, M. Cabero, L. Cadonati, G. Cagnoli, C. Cahillane, J. Calderón Bustillo, T. A. Callister, E. Calloni, J. B. Camp, W. A. Campbell, M. Canepa, K. C. Cannon, H. Cao, J. Cao, E. Capocasa, F. Carbognani, S. Caride, M. F. Carney, G. Carullo, J. Casanueva Diaz, C. Casentini, S. Caudill, M. Cavaglia, F. Cavalier, R. Cavalieri, G. Cella, P. Cerdá-Durán, G. Cerretani, E. Cesarini, O. Chaibi, K. Chakravarti, S. J. Chamberlin, M. Chan, S. Chao, P. Charlton, E. A. Chase, E. Chassande-Mottin, D. Chatterjee, M. Chaturvedi, K. Chatziioannou, B. D. Cheeseboro, H. Y. Chen, X. Chen, Y. Chen, H.-P. Cheng, C. K. Cheong, H. Y. Chia, A. Chincarini, A. Chiummo, G. Cho, H. S. Cho, M. Cho, N. Christensen, Q. Chu, S. Chua, K. W. Chung, S. Chung, G. Ciani, A. A. Ciobanu, R. Ciolfi, F. Cipriano, A. Cirone, F. Clara, J. A. Clark, P. Clearwater, F. Cleva, C. Cocchieri, E. Coccia, P.-F. Cohadon, D. Cohen, R. Colgan, M. Colleoni, C. G. Collette, C. Collins, L. R. Cominsky, M. Constancio Jr, L. Conti, S. J. Cooper, P. Corban, T. R. Corbitt, I. Cordero-Carrión, K. R. Corley, N. Cornish, A. Corsi, S. Cortese, C. A. Costa, R. Cotesta, M. W. Coughlin, S. B. Coughlin, J.-P. Coulon, S. T. Countryman, P. Couvares, P. B. Covas, E. E. Cowan, D. M. Coward, M. J. Cowart, D. C. Coyne, R. Coyne, J. D. E. Creighton, T. D. Creighton, J. Cripe, M. Croquette, S. G. Crowder, A. Cumming, L. Cunningham, E. Cuoco, T. Dal Canton, G. Dálya, S. L. Danilishin, S. D’Antonio, K. Danzmann, A. Dasgupta, C. F. Da Silva Costa, L. E. H. Datrier, V. Dattilo, I. Dave, M. Davier, D. Davis, E. J. Daw, D. DeBra, M. Deenadayalan, J. Degallaix, M. De Laurentis, S. Deleglise, W. Del Pozzo, L. M. DeMarchi, N. Demos, T. Dent, R. De Pietri, J. Derby, R. De Rosa, C. De Rossi, R. DeSalvo, O. de Varona, S. Dhurandhar, M. C. Díaz, T. Dietrich, L. Di Fiore, M. Di Giovanni, T. Di Girolamo, A. Di Lieto, B. Ding, S. Di Pace, I. Di Palma, F. Di Renzo, A. Dmitriev, Z. Doctor, F. Donovan, K. L. Dooley, S. Doravari, I. Dorrington, T. P. Downes, M. Drago, J. C. Driggers, Z. Du, J.-G. Ducoin, P. Dupej, S. E. Dwyer, P. J. Easter, T. B. Edo, M. C. Edwards, A. Effler, P. Ehrens, J. Eichholz, S. S. Eikenberry, M. Eisenmann, R. A. Eisenstein, R. C. Essick, H. Estelles, D. Estevez, Z. B. Etienne, T. Etzel, M. Evans, T. M. Evans, V. Fafone, H. Fair, S. Fairhurst, X. Fan, S. Farinon, B. Farr, W. M. Farr, E. J. Fauchon-Jones, M. Favata, M. Fays, M. Fazio, C. Fee, J. Feicht, M. M. Fejer, F. Feng, A. Fernandez-Galiana, I. Ferrante, E. C. Ferreira, T. A. Ferreira, F. Ferrini, F. Fidecaro, I. Fiori, D. Fiorucci, M. Fishbach, R. P. Fisher, J. M. Fishner, M. Fitz-Axen, R. Flaminio, M. Fletcher, E. Flynn, H. Fong, J. A. Font, P. W. F. Forsyth, J.-D. Fournier, S. Frasca, F. Frasconi, Z. Frei, A. Freise, R. Frey, V. Frey, P. Fritschel, V. V. Frolov, P. Fulda, M. Fyffe, H. A. Gabbard, B. U. Gadre, S. M. Gaebel, J. R. Gair, L. Gammaitoni, M. R. Ganija, S. G. Gaonkar, A. Garcia, C. García-Quirós, F. Garufi, B. Gateley, S. Gaudio, G. Gaur, V. Gayathri, G. Gemme, E. Genin, A. Gennai, D. George, J. George, L. Gergely, V. Germain, S. Ghonge, Abhirup Ghosh, Archisman Ghosh, S. Ghosh, B. Giacomazzo, J. A. Giaime, K. D. Giardina, A. Giazotto, K. Gill, G. Giordano, L. Glover, P. Godwin, E. Goetz, R. Goetz, B. Goncharov, G. González, J. M. Gonzalez Castro, A. Gopakumar, M. L. Gorodetsky, S. E. Gossan, M. Gosselin, R. Gouaty, A. Grado, C. Graef, M. Granata, A. Grant, S. Gras, P. Grassia, C. Gray, R. Gray, G. Greco, A. C. Green, R. Green, E. M. Gretarsson, P. Groot, H. Grote, S. Grunewald, P. Gruning, G. M. Guidi, H. K. Gulati, Y. Guo, A. Gupta, M. K. Gupta, E. K. Gustafson, R. Gustafson, L. Haegel, O. Halim, B. R. Hall, E. D. Hall, E. Z. Hamilton, G. Hammond, M. Haney, M. M. Hanke, J. Hanks, C. Hanna, M. D. Hannam, O. A. Hannuksela, J. Hanson, T. Hardwick, K. Haris, J. Harms, G. M. Harry, I. W. Harry, C.-J. Haster, K. Haughian, F. J. Hayes, J. Healy, A. Heidmann, M. C. Heintze, H. Heitmann, P. Hello, G. Hemming, M. Hendry, I. S. Heng, J. Hennig, A. W. Heptonstall, Francisco Hernandez Vivanco, M. Heurs, S. Hild, T. Hinderer, D. Hoak, S. Hochheim, D. Hofman, A. M. Holgado, N. A. Holland, K. Holt, D. E. Holz, P. Hopkins, C. Horst, J. Hough, E. J. Howell, C. G. Hoy, A. Hreibi, Y. Huang, E. A. Huerta, D. Huet, B. Hughey, M. Hulko, S. Husa, S. H. Huttner, T. Huynh-Dinh, B. Idzkowski, A. Iess, C. Ingram, R. Inta, G. Intini, B. Irwin, H. N. Isa, J.-M. Isac, M. Isi, B. R. Iyer, K. Izumi, T. Jacqmin, S. J. Jadhav, K. Jani, N. N. Janthalur, P. Jaranowski, A. C. Jenkins, J. Jiang, D. S. Johnson, N. K. Johnson-McDaniel, A. W. Jones, D. I. Jones, R. J. G. Jonker, L. Ju, J. Junker, C. V. Kalaghatgi, V. Kalogera, B. Kamai, S. Kandhasamy, G. Kang, J. B. Kanner, S. J. Kapadia, K. S. Karvinen, R. Kashyap, M. Kasprzack, S. Katsanevas, E. Katsavounidis, W. Katzman, S. Kaufer, K. Kawabe, N. V. Keerthana, F. Kefelian, R. Kennedy, J. S. Key, F. Y. Khalili, H. Khan, I. Khan, S. Khan, Z. Khan10, E. A. Khazanov, M. Khursheed, N. Kijbunchoo, Chunglee Kim, J. C. Kim, K. Kim, C. Kimball, P. J. King, M. Kinley-Hanlon, R. Kirchhoff, J. S. Kissel, L. Kleybolte, J. H. Klika, S. Klimenko, T. D. Knowles, P. Koch, S. M. Koehlenbeck, G. Koekoek, S. Koley, V. Kondrashov, A. Kontos, N. Koper, M. Korobko, W. Z. Korth, I. Kowalska, D. B. Kozak, V. Kringel, N. Krishnendu, A. Królak, G. Kuehn, A. Kumar, P. Kumar, R. Kumar, S. Kumar, L. Kuo, A. Kutynia, S. Kwang, B. D. Lackey, K. H. Lai, T. L. Lam, M. Landry, B. B. Lane, R. N. Lang, J. Lange, B. Lantz, R. K. Lanza, A. Lartaux-Vollard, P. D. Lasky, M. Laxen, A. Lazzarini, C. Lazzaro, P. Leaci, S. Leavey, Y. K. Lecoeuche, C. H. Lee, H. K. Lee, H. M. Lee, H. W. Lee, J. Lee, K. Lee, J. Lehmann, A. Lenon, N. Leroy, N. Letendre, Y. Levin, J. Li, K. J. L. Li, T. G. F. Li, X. Li, F. Lin, F. Linde, S. D. Linker, T. B. Littenberg, J. Liu, X. Liu, R. K. L. Lo, L. A. Lockerbie, L. T. London, A. Longo, M. Lorenzini, V. Loriette, M. Lormand, G. Losurdo, J. D. Lough, C. O. Lousto, G. Lovelace, M. E. Lower, H. Lück, D. Lumaca, A. P. Lundgren, R. Lynch, Y. Ma, R. Macas, S. Macfoy, M. MacInnis, D. M. Macleod, A. Macquet, F. Magaña-Sandoval, L. Magaña Zertuche, R. M. Magee, E. Majorana, I. Maksimovic, A. Malik, N. Man, V. Mandic, V. Mangano, G. L. Mansell, M. Manske, M. Mantovani, F. Marchesoni, F. Marion, S. Márka, Z. Márka, C. Markakis, A. S. Markosyan, A. Markowitz, E. Maros, A. Marquina, S. Marsat, F. Martelli, I. W. Martin, R. M. Martin, D. V. Martynov, K. Mason, E. Massera, A. Masserot, T. J. Massinger, M. Masso-Reid, S. Mastrogiovanni, A. Matas, F. Matichard, L. Matone, N. Mavalvala, N. Mazumder, J. J. McCann, R. McCarthy, D. E. McClelland, S. McCormick, L. McCuller, S. C. McGuire, J. McIver, D. J. McManus, T. McRae, S. T. McWilliams, D. Meacher, G. D. Meadors, M. Mehmet, A. K. Mehta, J. Meidam, A. Melatos, G. Mendell, R. A. Mercer, L. Mereni, E. L. Merilh, M. Merzougui, S. Meshkov, C. Messenger, C. Messick, R. Metzdorff, P. M. Meyers, H. Miao, C. Michel, H. Middleton, E. E. Mikhailov, L. Milano, A. L. Miller, A. Miller, M. Millhouse, J. C. Mills, M. C. Milovich-Goff, O. Minazzoli, Y. Minenkov, A. Mishkin, C. Mishra, T. Mistry, S. Mitra, V. P. Mitrofanov, G. Mitselmakher, R. Mittleman, G. Mo, D. Moffa, K. Mogushi, S. R. P. Mohapatra, M. Montani, C. J. Moore, D. Moraru, G. Moreno, S. Morisaki, B. Mours, C. M. Mow-Lowry, Arunava Mukherjee, D. Mukherjee, S. Mukherjee, N. Mukund, A. Mullavey, J. Munch, E. A. Muñiz, M. Muratore, P. G. Murray, A. Nagar, I. Nardecchia, L. Naticchioni, R. K. Nayak, J. Neilson, G. Nelemans, T. J. N. Nelson, M. Nery, A. Neunzert, K. Y. Ng, S. Ng, P. Nguyen, D. Nichols, A. B. Nielsen, S. Nissanke, A. Nitz, F. Nocera, C. North, L. K. Nuttall, M. Obergaulinger, J. Oberling, B. D. O’Brien, G. D. O’Dea, G. H. Ogin, J. J. Oh, S. H. Oh, F. Ohme, H. Ohta, M. A. Okada, M. Oliver, P. Oppermann, Richard J. Oram, B. O’Reilly, R. G. Ormiston, L. F. Ortega, R. O’Shaughnessy, S. Ossokine, D. J. Ottaway, H. Overmier, B. J. Owen, A. E. Pace, G. Pagano, M. A. Page, A. Pai, S. A. Pai, J. R. Palamos, O. Palashov, C. Palomba, A. Pal-Singh, Huang-Wei Pan, B. Pang, P. T. H. Pang, C. Pankow, F. Pannarale, B. C. Pant, F. Paoletti, A. Paoli, M. A. Papa, A. Parida, ascucci, A. Pasqualetti, R. Passaquieti, D. Passuello, M. Patil, B. Patricelli, B. L. Pearlstone, C. Pedersen, M. Pedraza, R. Pedurand, A. Pele, S. Penn, A. Perego, C. J. Perez, A. Perreca, H. P. Pfeiffer, M. Phelps, K. S. Phukon, O. J. Piccinni, M. Pichot, F. Piergiovanni, G. Pillant, L. Pinard, M. Pirello, M. Pitkin, R. Poggiani, D. Y. T. Pong, S. Ponrathnam, P. Popolizio, E. K. Porter, J. Powell, A. K. Prajapati, J. Prasad, K. Prasai, R. Prasanna, G. Pratten, T. Prestegard, S. Privitera, G. A. Prodi, L. G. Prokhorov, O. Puncken, M. Punturo, P. Puppo, M. Pürrer, H. Qi, V. Quetschke, P. J. Quinonez, E. A. Quintero, R. Quitzow-James, F. J. Raab, H. Radkins, N. Radulescu, P. Raffai, S. Raja, C. Rajan, B. Rajbhandari, M. Rakhmanov, K. E. Ramirez, A. Ramos-Buades, Javed Rana, K. Rao, P. Rapagnani, V. Raymond, M. Razzano, J. Read, T. Regimbau, L. Rei, S. Reid, D. H. Reitze, W. Ren, F. Ricci, C. J. Richardson, J. W. Richardson, P M Ricker, G. M. Riemenschneider, K. Riles, M. Rizzo, N. A. Robertson, R. Robie, F. Robinet, A. Rocchi, L. Rolland, J. G. Rollins, V. J. Roma, M. Romanelli, R. Romano, C. L. Romel, J. H. Romie, K. Rose, D. Rosińska, S. G. Rosofsky, M. P. Ross, S. Rowan, A. Rüdiger, P. Ruggi, G. Rutins, K. Ryan, S. Sachdev, T. Sadecki, M. Sakellariadou, O. Salafia, L. Salconi, M. Saleem, F. Salemi, A. Samajdar, L. Sammut, E. J. Sanchez, L. E. Sanchez, N. Sanchis-Gual, V. Sandberg, J. R. Sanders, K. A. Santiago, N. Sarin, B. Sassolas, B. S. Sathyaprakash, P. R. Saulson, O. Sauter, R. L. Savage, P. Schale, M. Scheel, J. Scheuer, P. Schmidt, R. Schnabel, R. M. S. Schofield, A. Schönbeck, E. Schreiber, B. W. Schulte, B. F. Schutz, S. G. Schwalbe, J. Scott, S. M. Scott, E. Seidel, D. Sellers, A. S. Sengupta, N. Sennett, D. Sentenac, V. Sequino, A. Sergeev, Y. Setyawati, D. A. Shaddock, T. Shaffer, M. S. Shahriar, M. B. Shaner, L. Shao, P. Sharma, P. Shawhan, H. Shen, R. Shink, D. H. Shoemaker, D. M. Shoemaker, S. ShyamSundar, K. Siellez, M. Sieniawska, D. Sigg, A. D. Silva, L. P. Singer, N. Singh, A. Singhal, A. M. Sintes, S. Sitmukhambetov, V. Skliris, B. J. J. Slagmolen, T. J. Slaven-Blair, J. R. Smith, R. J. E. Smith, S. Somala, E. J. Son, B. Sorazu, F. Sorrentino, T. Souradeep, E. Sowell, A. P. Spencer, A. K. Srivastava, V. Srivastava, K. Staats, C. Stachie, M. Standke, D. A. Steer, M. Steinke, J. Steinlechner, S. Steinlechner, D. Steinmeyer, S. P. Stevenson, D. Stocks, R. Stone, D. J. Stops, K. A. Strain, G. Stratta, S. E. Strigin, A. Strunk, R. Sturani, A. L. Stuver, V. Sudhir, T. Z. Summerscales, L. Sun, S. Sunil, J. Suresh, P. J. Sutton, B. L. Swinkels, M. J. Szczepańczyk, M. Tacca, S. C. Tait, C. Talbot, D. Talukder, D. B. Tanner, M. Tápai, A. Taracchini, J. D. Tasson, R. Taylor, F. Thies, M. Thomas, P. Thomas, S. R. Thondapu, K. A. Thorne, E. Thrane, Shubhanshu Tiwari, Srishti Tiwari, V. Tiwari, K. Toland, M. Tonelli, Z. Tornasi, A. Torres-Forne, C. I. Torrie, D. Töyrä, F. Travasso, G. Traylor, M. C. Tringali, A. Trovato, L. Trozzo, R. Trudeau, K. W. Tsang, M. Tse, R. Tso, L. Tsukada, D. Tsuna, D. Tuyenbayev, K. Ueno, D. Ugolini, C. S. Unnikrishnan, A. L. Urban, S. A. Usman, H. Vahlbruch, G. Vajente, G. Valdes, N. van Bakel, M. van Beuzekom, J. F. J. van den Brand, C. Van Den Broeck, D. C. Vander-Hyde, J. V. van Heijningen, L. van der Schaaf, A. A. van Veggel, M. Vardaro, V. Varma, S. Vass, M. Vasúth, A. Vecchio, G. Vedovato, J. Veitch, P. J. Veitch, K. Venkateswara, G. Venugopalan, D. Verkindt, F. Vetrano, A. Vicere, A. D. Viets, D. J. Vine, J.-Y. Vinet, S. Vitale, T. Vo, H. Vocca, C. Vorvick, S. P. Vyatchanin, A. R. Wade, L. E. Wade, M. Wade, R. Walet, M. Walker, L. Wallace, S. Walsh, G. Wang, H. Wang, J. Z. Wang, W. H. Wang, Y. F. Wang, R. L. Ward, Z. A. Warden, J. Warner, M. Was, J. Watchi, B. Weaver, L.-W. Wei, M. Weinert, A. J. Weinstein, R. Weiss, F. Wellmann, L. Wen, E. K. Wessel, P. Weßels, J. W. Westhouse, K. Wette, J. T. Whelan, L. V. White, B. F. Whiting, C. Whittle, D. M. Wilken, D. Williams, A. R. Williamson, J. L. Willis, B. Willke, M. H. Wimmer, W. Winkler, C. C. Wipf, H. Wittel, G. Woan, J. Woehler, J. K. Wofford, J. Worden, J. L. Wright, D. S. Wu, D. M. Wysocki, L. Xiao, H. Yamamoto, C. C. Yancey, L. Yang, M. J. Yap, M. Yazback, D. W. Yeeles, Hang Yu, Haocun Yu, S. H. R. Yuen, M. Yvert, A. K. Zadrożny, M. Zanolin, F. Zappa, T. Zelenova, J.-P. Zendri, M. Zevin, J. Zhang, L. Zhang, T. Zhang, C. Zhao, M. Zhou, Z. Zhou, X. J. Zhu, A. B. Zimmerman, Y. Zlochower, M. E. Zucker, and J. Zweizig

Subjects
Astrophysics
Abstract

We present the results from three gravitational-wave searches for coalescing compact binaries with component masses above1M during the first and second observing runs of the advanced gravitational-wave detector network. During the first observing run (O1), from September 12, 2015 to January 19, 2016, gravitational waves from three binary black hole mergers were detected. The second observing run (O2), which ran from November 30, 2016 to August 25, 2017, saw the first detection of gravitational waves from a binary neutron star in spiral, in addition to the observation of gravitational waves from a total of seven binary black hole mergers, four of which we report here for the first time: GW170729, GW170809, GW170818, and GW170823. For all significant gravitational-wave events, we provide estimates of the source properties. The detected binary black holes have total masses between18.6þ3.2−0.7M and 84.4þ15.8−11.1M and range in distance between 320þ120−110 and 2840þ1400−1360Mpc. No neutron star–black hole mergers were detected. In addition to highly significant gravitational-wave events, we also provide a list of marginal event candidates with an estimated false-alarm rate less than 1 per 30 days. From these results over the first two observing runs, which include approximately one gravitational-wave detection per 15 days of data searched, we infer merger rates at the 90% confidence intervals of 110−3840Gpc−3y−1 for binary neutron stars and 9.7−101Gpc−3y−1 for binary black holes assuming fixed population distributions and determine a neutron star–black hole merger rate 90% upper limit of 610Gpc−3y−1.

Published
2019
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