988 results on '"Verhagen H"'
Search Results
2. The Sac Evolution Imaging Follow-Up after EVAR: an international expert opinion-based Delphi consensus study
- Author
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Tinelli, G, D’Oria, M, Sica, S, Mani, K, Rancic, Z, Resh, T, Beccia, F, Azizzadeh, A, Da Volta Ferreira, M, Gargiulo, M, Lepidi, S, Tshomba, Y, Oderich, G, Haulon, S, Beck, A, Hertault, A, Savlania, A, Froio, A, Giaquinta, A, Zimmermann, A, Psyllas, A, Wanhainen, A, Marchetti, A, Queiroz, A, Kahlberg, A, Reyes-Valdivia, A, Schanzer, A, Edinburgh Vascular, A, Freyrie, A, Lorido, A, Millon, A, Ippoliti, A, Abai, B, Mees, B, Reutersberg, B, Maurel, B, Michel, B, Wahlgren, C, Cavazzini, C, Setacci, C, Lee, C, Ferrer, C, Bicknell, C, Raphaël, C, Clair, D, Dawson, D, Arnaoutakis, D, Böckler, D, Kotelis, D, Mujagic, E, Chisci, E, Cieri, E, Gallitto, E, Marone, E, Ducasse, E, Verzini, F, Pecoraro, F, Serracino-Inglott, F, Benedetto, F, Speziale, F, Stilo, F, Álvarez-Marcos, F, Pagliariccio, G, Piffaretti, G, Lanza, G, Philipp, G, Geenberg, G, Jung, G, Melissano, G, Veraldi, G, Parlani, G, Faggioli, G, de Donato, G, Simonte, G, Colacchio, G, De Caridi, G, Pratesi, G, Spinella, G, Torsello, G, Leong Tan, G, Magee, G, Verhagen, H, Andrew, H, Koleilat, I, Ohman, J, de Vries, J, Budtz-Lilly, J, Black, J, Eldrup-Jorgensen, J, Hockley, J, Bath, J, Sobocinski, J, van Herwaarden, J, Reinhard, K, Orion, K, Amankwah, K, Bertoglio, L, di Marzo, L, Garriboli, L, Rizzo, L, Hakimi, M, Sheahan, M, Khashram, M, Schermerhorn, M, Lescan, M, Conrad, M, Davies, M, Czerny, M, Orrico, M, Eagleton, M, Smeds, M, Taurino, M, Wohlauer, M, Sharafuddin, M, Anna-Leonie, M, Reijnen, M, Antonello, M, Piazza, M, Settembre, N, Mouawad, N, Tsilimparis, N, Dias, N, Martinelli, O, Frigatti, P, Sirignano, P, Chong, P, Bevis, P, Dimuzio, P, Henke, P, Düppers, P, Holt, P, Helmiö, P, Vriens, P, Pulli, R, Bellosta, R, Micheli, R, Veeraswamy, R, Cuff, R, Chiappa, R, Gattuso, R, Pini, R, Dalman, R, Milner, R, Scali, S, Bahia, S, Laukontaus, S, Trimarchi, S, Fernandez-Alonso, S, Deglise, S, Bellmunt-Montoya, S, Hofer, S, Yusuf, S, Ronchey, S, Bartoli, S, Bonvini, S, Camparini, S, Fazzini, S, Pirrelli, S, Hörer, T, Bisdas, T, Vasudevan, T, Lattmann, T, Wyss, T, Maldonado, T, Pfammatter, T, Kölbel, T, Jakimowicz, T, Donati, T, Tracci, M, Bracale, U, Tolva, V, Riambau, V, Palazzo, V, Makaloski, V, Regula S, V, Dorigo, W, Mansour, W, Van den Eynde, W, Tinelli, Giovanni, D’Oria, Mario, Sica, Simona, Mani, Kevin, Rancic, Zoran, Resh, Timothy Andrew, Beccia, Flavia, Azizzadeh, Ali, Da Volta Ferreira, Marcelo Martins, Gargiulo, Mauro, Lepidi, Sandro, Tshomba, Yamume, Oderich, Gustavo S., Haulon, Stephan, Beck, Adam W., Hertault, Adrien, Savlania, Ajay, Froio, Alberto, Giaquinta, Alessia, Zimmermann, Alexander, Psyllas, Anastasios, Wanhainen, Anders, Marchetti, Andrea Ascoli, Queiroz, Andre Brito, Kahlberg, Andrea, Reyes-Valdivia, Andrés, Schanzer, Andres, Edinburgh Vascular, Andrew Tambyraja, Freyrie, Antonio, Lorido, Antonio, Millon, Antoine, Ippoliti, Arnaldo, Abai, Babak, Mees, Barend, Reutersberg, Benedikt, Maurel, Blandine, Michel, Bosiers, Wahlgren, Carl Magnus, Cavazzini, Carlo, Setacci, Carlo, Lee, Cheong Jun, Ferrer, Ciro, Bicknell, Colin, Raphaël, Coscas, Clair, Daniel, Dawson, David L., Arnaoutakis, Dean J., Böckler, Dittmar, Kotelis, Drosos, Mujagic, Edin, Chisci, Emiliano, Cieri, Enrico, Gallitto, Enrico, Marone, Enrico Maria, Ducasse, Eric, Verzini, Fabio, Pecoraro, Felice, Serracino-Inglott, Ferdinand, Benedetto, Filippo, Speziale, Francesco, Stilo, Francesco, Álvarez-Marcos, Francisco, Pagliariccio, Gabriele, Piffaretti, Gabriele, Lanza, Gaetano, Philipp, Geisbüsch, Geenberg, George, Jung, Georg, Melissano, Germano, Veraldi, Gian Franco, Parlani, Gianbattista, Faggioli, Gianluca, de Donato, Gianmarco, Simonte, Gioele, Colacchio, Giovanni, De Caridi, Giovanni, Pratesi, Giovanni, Spinella, Giovanni, Torsello, Giovanni, Leong Tan, Glenn Wei, Magee, Gregory A., Verhagen, Hence, Andrew, Holden, Koleilat, Issam, Ohman, J Westley, de Vries, J. P. P. M., Budtz-Lilly, Jacob, Black, James, Eldrup-Jorgensen, Jens, Hockley, Joe, Bath, Jonathan, Sobocinski, Jonathan, van Herwaarden, Joost A., Reinhard, Kopp, Orion, Kristine C., Amankwah, Kwame, Bertoglio, Luca, di Marzo, Luca, Garriboli, Luca, Rizzo, Luigi, Hakimi, Maani, Sheahan, Malachi, Khashram, Manar, Schermerhorn, Marc, Lescan, Mario, Conrad, Mark, Davies, Mark G., Czerny, Martin, Orrico, Matteo, Eagleton, Matthew J., Smeds, Matthew R., Taurino, Maurizio, Wohlauer, Max, Sharafuddin, Mel J., Anna-Leonie, Menges, Reijnen, Michel, Antonello, Michele, Piazza, Michele, Settembre, Nicla, Mouawad, Nicolas J., Tsilimparis, Nikolaos, Dias, Nuno, Martinelli, Ombretta, Frigatti, Paolo, Sirignano, Pasqualino, Chong, Patrick, Bevis, Paul, DiMuzio, Paul, Henke, Peter, Düppers, Philip, Holt, Peter, Helmiö, Päivi, Vriens, Patrick, Pulli, Raffaele, Bellosta, Raffaello, Micheli, Raimondo, Veeraswamy, Ravi, Cuff, Robert, Chiappa, Roberto, Gattuso, Roberto, Pini, Rodolfo, Dalman, Ronald L., Milner, Ross, Scali, Salvatore T., Bahia, Sandeep, Laukontaus, Sani, Trimarchi, Santi, Fernandez-Alonso, Sebastian, Deglise, Sebastien, Bellmunt-Montoya, Sergi, Hofer, Simone, Yusuf, Syed W., Ronchey, Sonia, Bartoli, Stefano, Bonvini, Stefano, Camparini, Stefano, Fazzini, Stefano, Pirrelli, Stefano, Hörer, Tal, Bisdas, Theodosios, Vasudevan, Thodur, Lattmann, Thomas, Wyss, Thomas Rudolf, Maldonado, Thomas, Pfammatter, Thomas, Kölbel, Tilo, Jakimowicz, Tomasz, Donati, Tommaso, Tracci, Margaret, Bracale, Umberto Marcello, Tolva, Valerio Stefano, Riambau, Vincent, Palazzo, Vincenzo, Makaloski, Vladimir, Regula S, Von Allmen, Dorigo, Walter, Mansour, Wassim, Van den Eynde, Wouter, Tinelli, G, D’Oria, M, Sica, S, Mani, K, Rancic, Z, Resh, T, Beccia, F, Azizzadeh, A, Da Volta Ferreira, M, Gargiulo, M, Lepidi, S, Tshomba, Y, Oderich, G, Haulon, S, Beck, A, Hertault, A, Savlania, A, Froio, A, Giaquinta, A, Zimmermann, A, Psyllas, A, Wanhainen, A, Marchetti, A, Queiroz, A, Kahlberg, A, Reyes-Valdivia, A, Schanzer, A, Edinburgh Vascular, A, Freyrie, A, Lorido, A, Millon, A, Ippoliti, A, Abai, B, Mees, B, Reutersberg, B, Maurel, B, Michel, B, Wahlgren, C, Cavazzini, C, Setacci, C, Lee, C, Ferrer, C, Bicknell, C, Raphaël, C, Clair, D, Dawson, D, Arnaoutakis, D, Böckler, D, Kotelis, D, Mujagic, E, Chisci, E, Cieri, E, Gallitto, E, Marone, E, Ducasse, E, Verzini, F, Pecoraro, F, Serracino-Inglott, F, Benedetto, F, Speziale, F, Stilo, F, Álvarez-Marcos, F, Pagliariccio, G, Piffaretti, G, Lanza, G, Philipp, G, Geenberg, G, Jung, G, Melissano, G, Veraldi, G, Parlani, G, Faggioli, G, de Donato, G, Simonte, G, Colacchio, G, De Caridi, G, Pratesi, G, Spinella, G, Torsello, G, Leong Tan, G, Magee, G, Verhagen, H, Andrew, H, Koleilat, I, Ohman, J, de Vries, J, Budtz-Lilly, J, Black, J, Eldrup-Jorgensen, J, Hockley, J, Bath, J, Sobocinski, J, van Herwaarden, J, Reinhard, K, Orion, K, Amankwah, K, Bertoglio, L, di Marzo, L, Garriboli, L, Rizzo, L, Hakimi, M, Sheahan, M, Khashram, M, Schermerhorn, M, Lescan, M, Conrad, M, Davies, M, Czerny, M, Orrico, M, Eagleton, M, Smeds, M, Taurino, M, Wohlauer, M, Sharafuddin, M, Anna-Leonie, M, Reijnen, M, Antonello, M, Piazza, M, Settembre, N, Mouawad, N, Tsilimparis, N, Dias, N, Martinelli, O, Frigatti, P, Sirignano, P, Chong, P, Bevis, P, Dimuzio, P, Henke, P, Düppers, P, Holt, P, Helmiö, P, Vriens, P, Pulli, R, Bellosta, R, Micheli, R, Veeraswamy, R, Cuff, R, Chiappa, R, Gattuso, R, Pini, R, Dalman, R, Milner, R, Scali, S, Bahia, S, Laukontaus, S, Trimarchi, S, Fernandez-Alonso, S, Deglise, S, Bellmunt-Montoya, S, Hofer, S, Yusuf, S, Ronchey, S, Bartoli, S, Bonvini, S, Camparini, S, Fazzini, S, Pirrelli, S, Hörer, T, Bisdas, T, Vasudevan, T, Lattmann, T, Wyss, T, Maldonado, T, Pfammatter, T, Kölbel, T, Jakimowicz, T, Donati, T, Tracci, M, Bracale, U, Tolva, V, Riambau, V, Palazzo, V, Makaloski, V, Regula S, V, Dorigo, W, Mansour, W, Van den Eynde, W, Tinelli, Giovanni, D’Oria, Mario, Sica, Simona, Mani, Kevin, Rancic, Zoran, Resh, Timothy Andrew, Beccia, Flavia, Azizzadeh, Ali, Da Volta Ferreira, Marcelo Martins, Gargiulo, Mauro, Lepidi, Sandro, Tshomba, Yamume, Oderich, Gustavo S., Haulon, Stephan, Beck, Adam W., Hertault, Adrien, Savlania, Ajay, Froio, Alberto, Giaquinta, Alessia, Zimmermann, Alexander, Psyllas, Anastasios, Wanhainen, Anders, Marchetti, Andrea Ascoli, Queiroz, Andre Brito, Kahlberg, Andrea, Reyes-Valdivia, Andrés, Schanzer, Andres, Edinburgh Vascular, Andrew Tambyraja, Freyrie, Antonio, Lorido, Antonio, Millon, Antoine, Ippoliti, Arnaldo, Abai, Babak, Mees, Barend, Reutersberg, Benedikt, Maurel, Blandine, Michel, Bosiers, Wahlgren, Carl Magnus, Cavazzini, Carlo, Setacci, Carlo, Lee, Cheong Jun, Ferrer, Ciro, Bicknell, Colin, Raphaël, Coscas, Clair, Daniel, Dawson, David L., Arnaoutakis, Dean J., Böckler, Dittmar, Kotelis, Drosos, Mujagic, Edin, Chisci, Emiliano, Cieri, Enrico, Gallitto, Enrico, Marone, Enrico Maria, Ducasse, Eric, Verzini, Fabio, Pecoraro, Felice, Serracino-Inglott, Ferdinand, Benedetto, Filippo, Speziale, Francesco, Stilo, Francesco, Álvarez-Marcos, Francisco, Pagliariccio, Gabriele, Piffaretti, Gabriele, Lanza, Gaetano, Philipp, Geisbüsch, Geenberg, George, Jung, Georg, Melissano, Germano, Veraldi, Gian Franco, Parlani, Gianbattista, Faggioli, Gianluca, de Donato, Gianmarco, Simonte, Gioele, Colacchio, Giovanni, De Caridi, Giovanni, Pratesi, Giovanni, Spinella, Giovanni, Torsello, Giovanni, Leong Tan, Glenn Wei, Magee, Gregory A., Verhagen, Hence, Andrew, Holden, Koleilat, Issam, Ohman, J Westley, de Vries, J. P. P. M., Budtz-Lilly, Jacob, Black, James, Eldrup-Jorgensen, Jens, Hockley, Joe, Bath, Jonathan, Sobocinski, Jonathan, van Herwaarden, Joost A., Reinhard, Kopp, Orion, Kristine C., Amankwah, Kwame, Bertoglio, Luca, di Marzo, Luca, Garriboli, Luca, Rizzo, Luigi, Hakimi, Maani, Sheahan, Malachi, Khashram, Manar, Schermerhorn, Marc, Lescan, Mario, Conrad, Mark, Davies, Mark G., Czerny, Martin, Orrico, Matteo, Eagleton, Matthew J., Smeds, Matthew R., Taurino, Maurizio, Wohlauer, Max, Sharafuddin, Mel J., Anna-Leonie, Menges, Reijnen, Michel, Antonello, Michele, Piazza, Michele, Settembre, Nicla, Mouawad, Nicolas J., Tsilimparis, Nikolaos, Dias, Nuno, Martinelli, Ombretta, Frigatti, Paolo, Sirignano, Pasqualino, Chong, Patrick, Bevis, Paul, DiMuzio, Paul, Henke, Peter, Düppers, Philip, Holt, Peter, Helmiö, Päivi, Vriens, Patrick, Pulli, Raffaele, Bellosta, Raffaello, Micheli, Raimondo, Veeraswamy, Ravi, Cuff, Robert, Chiappa, Roberto, Gattuso, Roberto, Pini, Rodolfo, Dalman, Ronald L., Milner, Ross, Scali, Salvatore T., Bahia, Sandeep, Laukontaus, Sani, Trimarchi, Santi, Fernandez-Alonso, Sebastian, Deglise, Sebastien, Bellmunt-Montoya, Sergi, Hofer, Simone, Yusuf, Syed W., Ronchey, Sonia, Bartoli, Stefano, Bonvini, Stefano, Camparini, Stefano, Fazzini, Stefano, Pirrelli, Stefano, Hörer, Tal, Bisdas, Theodosios, Vasudevan, Thodur, Lattmann, Thomas, Wyss, Thomas Rudolf, Maldonado, Thomas, Pfammatter, Thomas, Kölbel, Tilo, Jakimowicz, Tomasz, Donati, Tommaso, Tracci, Margaret, Bracale, Umberto Marcello, Tolva, Valerio Stefano, Riambau, Vincent, Palazzo, Vincenzo, Makaloski, Vladimir, Regula S, Von Allmen, Dorigo, Walter, Mansour, Wassim, and Van den Eynde, Wouter
- Abstract
Objective: Management of follow-up protocols after endovascular aortic repair (EVAR), vary significantly between centres and is not standardized according to the sac regression. By designing an international expert-based Delphi consensus, the study aimed to create recommendations on follow-up after EVAR according to sac evolution. Methods: Eight facilitators created appropriate statements regarding the study topic that were voted, using a 4-point Likert scale, by a selected panel of international experts using a three-round modified Delphi consensus process. Based on the experts' responses, only those statements reaching a Grade A (full agreement ≥75%) or B (overall agreement ≥80% and full disagreement <5%) were included in the final document. Results: One-hundred and seventy-four participants were included in the final analysis, and each voted the initial 29 statements related to the definition of sac regression (Q1-Q9), EVAR follow-up (Q10-Q14), and the assessment and role of sac regression during follow-up (Q15-Q29). At the end of the process, 2 statements (6.9%) were rejected, 9 statements (31%) received a grade B consensus strength, and 18 (62.1%) reached a grade A consensus strength. Out of twenty-seven final statements, fifteen statements (55.6%) were classified as grade I, while twelve (44.4%) were classified as grade II. Experts agreed that sac regression should be considered an important indicator of EVAR success and always be assessed during follow-up after EVAR. Conclusions: Based on the elevated strength and high consistency of this international expert-based Delphi consensus, most of the statements might guide current clinical management of follow-up after EVAR according to the sac regression. Future studies are needed to clarify debated issues.
- Published
- 2024
3. Imaging of inflammatory cellular protagonists in human atherosclerosis: a dual-isotope SPECT approach
- Author
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Barrett, Hilary E., Meester, Eric J., van Gaalen, Kim, van der Heiden, Kim, Krenning, Boudewijn J., Beekman, Freek J., de Blois, Erik, de Swart, Jan, Verhagen, H J, Maina, Theodosia, Nock, Berthold A., Norenberg, Jeffrey P., de Jong, Marion, Gijsen, Frank J. H., and Bernsen, Monique R.
- Published
- 2020
- Full Text
- View/download PDF
4. In Patients with Aortic Graft Infections, Does EVAR Improve Long Term Survival Compared to Open Graft Resection?
- Author
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van Rijn, M. J. E., Rouwet, E. V., ten Raa, S., Hendriks, J. M., Verhagen, H. J. M., Ferguson, Mark K, Series editor, Skelly, Christopher L., editor, and Milner, Ross, editor
- Published
- 2017
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5. Assessment of Competence in EVAR Procedures: A Novel Rating Scale Developed by the Delphi Technique
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Aho, P., Back, M., Bicknell, C., Björses, K., Brunkwall, J., Dake, M., Dias, N., Dorenberg, E., Duvnjak, S., Falkenberg, M., Formgren, J., Holst, J., Kristmundsson, T., Langfeldt, S., Lindgren, H., Mafi, H., Malina, M., Mani, K., Modarai, B., Morgan, R., Nyman, N., Pärsson, H., Rasmussen, J., Resch, T., Shames, M., Van Den Berg, J.C., Van Herzeele, I., Verhagen, H., Verhoeven, E., Venermo, M., Vermassen, F., Wanhainen, A., Strøm, M., Lönn, L., Bech, B., Schroeder, T.V., and Konge, L.
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- 2017
- Full Text
- View/download PDF
6. Particle number concentration near road traffic in Amsterdam (the Netherlands): Comparison of standard and real-world emission factors
- Author
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Keuken, M.P., Moerman, M., Voogt, M., Zandveld, P., Verhagen, H., Stelwagen, U., and Jonge de, D.
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- 2016
- Full Text
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7. Association of Hospital Volume with Perioperative Mortality of Endovascular Repair of Complex Aortic Aneurysms: A Nationwide Cohort Study
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Alberga, Anna J., von Meijenfeldt, Gerdine C. I., Rastogi, Vinamr, de Bruin, Jorg L., Wever, Jan J., van Herwaarden, Joost A., Hamming, Jaap F., Hazenberg, Constantijn E. V. B., van Schaik, Jan, Mees, Barend M. E., van der Laan, Maarten J., Zeebregts, Clark J., Schurink, Geert W. H., Verhagen, Hence J. M., van den Akker, P. J., Akkersdijk, G. P., Akkersdijk, W. L., van Andringa de Kempenaer, M. G., Arts, C. H. P., Avontuur, A. M., Bakker, O. J., Balm, R., Barendregt, W. B., Bekken, J. A., Bender, M. H. M., Bendermacher, B. L. W., van den Berg, M., Beuk, R. J., Blankensteijn, J. D., Bode, A. S., Bodegom, M. E., van der Bogt, K. E. A., Boll, A. P. M., Booster, M. H., Borger van der Burg, B. L. S., de Borst, G. J., Bos-van Rossum, W. T. G. J., Bosma, J., Botman, J. M. J., Bouwman, L. H., Brehm, V., de Bruijn, M. T., de Bruin, J. L., Brummel, P., van Brussel, J. P., Buijk, S. E., Buimer, M. G., Buscher, H. C. J. L., Cancrinus, E., Castenmiller, P. H., Cazander, G., Cuypers, P. W. M., Daemen, J. H. C., Dawson, I., Dierikx, J. E., Dijkstra, M. L., Diks, J., Dinkelman, M. K., Dirven, M., Dolmans, D. E. J. G. J., van Dortmont, L. M. C., Drouven, J. W., van der Eb, M. M., Eefting, D., van Eijck, G. J. W. M., Elshof, J. W. M., Elsman, A. H. P., van der Elst, A., van Engeland, M. I. A., van Eps, G. S., Faber, M. J., de Fijter, W. M., Fioole, B., Fritschy, W. M., Fung Kon Jin, P. H. P., Geelkerken, R. H., van Gent, W. B., Glade, G. J., Govaert, B., Groenendijk, R. P. R., de Groot, H. G. W., van den Haak, R. F. F., de Haan, E. F. A., Hajer, G. F., Hamming, J. F., van Hattum, E. S., Hazenberg, C. E. V. B., Hedeman Joosten, P. P. A., Helleman, J. N., van der Hem, L. G., Hendriks, J. M., van Herwaarden, J. A., Heyligers, J. M. M., Hinnen, J. W., Hissink, R. J., Ho, G. H., den Hoed, P. T., Hoedt, M. T. C., van Hoek, F., Hoencamp, R., Hoffmann, W. H., Hoksbergen, A. W. J., Hollander, E. J. F., Huisman, L. C., Hulsebos, R. G., Huntjens, K. M. B., Idu, M. M., Jacobs, M. J. H. M., van der Jagt, M. F. P., Jansbeken, J. R. H., Janssen, R. J. L., Jiang, H. H. L., de Jong, S. C., Jongbloed-Winkel, T. A., Jongkind, V., Kapma, M. R., Keller, B. P. J. A., Jahrome, A. Khodadade, Kievit, J. K., Klemm, P. L., Klinkert, P., Koedam, N. A., Koelemaij, M. J. W., Kolkert, J. L. P., Koning, G. G., Koning, O. H. J., Konings, R., Krasznai, A. G., Kropman, R. H. J., Kruse, R. R., van der Laan, L., van der Laan, M. J., van Laanen, J. H. H., van Lammeren, G. W., Lamprou, D. A. A., Lardenoije, J. H. P., Lauret, G. J., Leenders, B. J. M., Legemate, D. A., Leij-Dekkers, V. J., Lemson, M. S., Lensvelt, M. M. A., Lijkwan, M. A., van der Linden, F. T. P. M., Lung, P. F. L., Loos, M. J. A., Loubert, M. C., van de Luijtgaarden, K. M., Mahmoud, D. E. A. K., Manshanden, C. G., Mat-Tens, E. C. J. L., Meerwaldt, R., Mees, B. M. E., Menting, T. P., Metz, R., de Mol van Otterloo, J. C. A., Molegraaf, M. J., Montauban van Swijn-Dregt, Y. C. A., Morak, M. J. M., van de Mortel, R. H. W., Mulder, W., Nagesser, S. K., Naves, C. C. L. M., Nederhoed, J. H., Nevenzel, A. M., de Nie, A. J., Nieuwenhuis, D. H., van Nieuwenhuizen, R. C., Nieuwenhui-Zen, J., Nio, D., Oomen, A. P. A., Oranen, B. I., Oskam, J., Palamba, H. W., Peppelenbosch, A. G., van Petersen, A. S., Petri, B. J., Pierie, M. E. N., Ploeg, A. J., Pol, R. A., Ponfoort, E. D., Poyck, P. P. C., Prent, A., ten Raa, S., Raymakers, J. T. F. J., Reichmann, B. L., Reijnen, M. M. P. J., de Ridder, J. A. M., Rijbroek, A., van Rijn, M. J. E., de Roo, R. A., Rouwet, E. V., Saleem, B. R., van Sambeek, M. R. H. M., Samyn, M. G., van't Sant, H. P., van Schaik, J., van Schaik, P. M., Scharn, D. M., Scheltinga, M. R. M., Schepers, A., Schlejen, P. M., Schlösser, F. J. V., Schol, F. P. G., Scholtes, V. P. W., Schouten, O., Schreve, M. A., Schurink, G. W. H., Sikkink, C. J. J. M., te Slaa, A., Smeets, H. J., Smeets, L., Smeets, R. R., de Smet, A. A. E. A., Smit, P. C., Smits, T. M., Snoeijs, M. G. J., Sondakh, A. O., Speijers, M. J., van der Steenhoven, T. J., van Sterkenburg, S. M. M., Stigter, D. A. A., Stokmans, R. A., Strating, R. P., Stultiëns, G. N. M., Sybrandy, J. E. M., Teijink, J. A. W., Telgenkamp, B. J., Testroote, M. J. G., Tha-in, T., The, R. M., Thijsse, W. J., Thomassen, I., Tielliu, I. F. J., van Tongeren, R. B. M., Toorop, R. J., Tournoij, E., Truijers, M., Türkcan, K., Nolthenius, R. P. Tutein, Ünlü, C., Vaes, R. H. D., Vahl, A. C., Veen, E. J., Veger, H. T. C., Veldman, M. G., Verhagen, H. J. M., Verhoeven, B. A. N., Vermeulen, C. F. W., Vermeulen, E. G. J., Vierhout, B. P., van der Vijver-Coppen, R. J., Visser, M. J. T., van der Vliet, J. A., van Vlijmen-van Keulen, C. J., van der Vorst, J. R., Vos, A. W. F., Vos, C. G., Vos, G. A., de Vos, B., Voûte, M. T., Vriens, B. H. R., Vriens, P. W. H. E., de Vries, D. K., de Vries, J. P. P. M., de Vries, M., de Vries, A. C., van der Waal, C., Waasdorp, E. J., de Vries, B. M. Wallis, van Walraven, L. A., van Wanroi, J. L., Warlé, M. C., van Weel, V., van Well, A. M. E., Welten, G. M. J. M., Wever, J. J., Wiersema, A. M., Wikkeling, O. R. M., Willaert, W. I. M., Wille, J., Willems, M. C. M., Willigendael, E. M., Wilschut, E. D., Wisselink, W., Witte, M. E., Wittens, C. H. A., Wong, C. Y., Yazar, O., Yeung, K. K., Zeebregts, C. J. A. M., van Zeeland, M. L. P., Physiology, ACS - Pulmonary hypertension & thrombosis, Surgery, ACS - Atherosclerosis & ischemic syndromes, ACS - Microcirculation, VU University medical center, AII - Inflammatory diseases, APH - Digital Health, Medical Biochemistry, ACS - Diabetes & metabolism, AII - Infectious diseases, and AGEM - Amsterdam Gastroenterology Endocrinology Metabolism
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volume-outcome ,complex AAA ,endovascular ,mortality - Abstract
Objective: We evaluate nationwide perioperative outcomes of complex EVAR and assess the volume-outcome association of complex EVAR. Summary of Background Data: Endovascular treatment with fenestrated (FEVAR) or branched (BEVAR) endografts is progressively used for excluding complex aortic aneurysms (complex AAs). It is unclear if a volumeoutcome association exists in endovascular treatment of complex AAs (complex EVAR). Methods: All patients prospectively registered in the Dutch Surgical Aneurysm Audit who underwent complex EVAR (FEVAR or BEVAR) between January 2016 and January 2020 were included. The effect of annual hospital volume on perioperative mortality was examined using multivariable logistic regression analyses. Patients were stratified into quartiles based on annual hospital volume to determine hospital volume categories. Results: We included 694 patients (539 FEVAR patients, 155 BEVAR patients). Perioperative mortality following FEVAR was 4.5% and 5.2% following BEVAR. Postoperative complication rates were 30.1% and 48.7%, respectively. The first quartile hospitals performed
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- 2023
8. Damage to grass dikes due to wave overtopping
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Le, Hai Trung, Verhagen, H. J., and Vrijling, J. K.
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- 2017
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9. Perioperative Complications are Associated With Adverse Long-Term Prognosis and Affect the Cause of Death After General Surgery
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Tjeertes, Elke K.M., Ultee, K. H. J., Stolker, R. J., Verhagen, H. J. M., Bastos Gonçalves, F. M., Hoofwijk, A. G. M., and Hoeks, S. E.
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- 2016
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10. Male-female differences in acute type B aortic dissection: the DisSEXion study
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Meccanici, F, primary, Thijssen, C G E, additional, Gokalp, A L, additional, De Bruin, J L, additional, Bekkers, J A, additional, Van Kimmenade, R R J, additional, Geuzebroek, G S C, additional, Poyck, P, additional, Ter Woorst, F J, additional, Post, M C, additional, Heijmen, R H, additional, Mokhles, M M, additional, Takkenberg, J J M, additional, Roos-Hesselink, J W, additional, and Verhagen, H J M, additional
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- 2022
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11. Real-world Performance of the New C3 Gore Excluder Stent-Graft: 1-year Results from the European C3 Module of the Global Registry for Endovascular Aortic Treatment (GREAT)
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Verhoeven, E.L.G., Katsargyris, A., Bachoo, P., Larzon, T., Fisher, R., Ettles, D., Boyle, J.R., Brunkwall, J., Böckler, D., Florek, H.-J., Stella, A., Kasprzak, P., Verhagen, H., and Riambau, V.
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- 2014
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12. Abstract 16384: Molecular Genetics of Familial Abdominal Aortic Aneurysms; a Focus on SLC2A10
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Burger, J, IJpma, A, Heijsman, D, Liu, H, van Heijningen, P, ten Hagen, T, Wessels, M, Bruggenwirth, H, Verhagen, H, Kanaar, R, Majoor-Krakauer, D, van der Pluijm, I, and Essers, J
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- 2017
13. Validation of biomarkers of food intake—critical assessment of candidate biomarkers
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Dragsted, L. O., Gao, Q., Scalbert, A., Vergères, G., Kolehmainen, M., Manach, C., Brennan, L., Afman, L. A., Wishart, D. S., Andres Lacueva, C., Garcia-Aloy, M., Verhagen, H., Feskens, E. J. M., and Praticò, G.
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- 2018
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14. MicroRNA-551b is highly expressed in hematopoietic stem cells and a biomarker for relapse and poor prognosis in acute myeloid leukemia
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de Leeuw, D C, Verhagen, H J M P, Denkers, F, Kavelaars, F G, Valk, P J M, Schuurhuis, G J, Ossenkoppele, G J, and Smit, L
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- 2016
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15. Endoluminal Treatment of Infrarenal Abdominal Aortic Aneurysm
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Verhagen, H., White, G. H., Perdikides, T., Geroulakos, George, editor, van Urk, Hero, editor, Hobson, Robert W., II, editor, and Calligaro, Keith D., editor
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- 2003
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16. Post-operative Surveillance and Long Term Outcome after Endovascular Aortic Aneurysm Repair in Patients with an Initial Post-operative Computed Tomography Angiogram Without Abnormalities: the Multicentre Retrospective ODYSSEUS Study
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Geraedts, Anna C.M., Mulay, Sana, Vahl, A. C., Verhagen, H. J.M., Wisselink, Willem, de Mik, Sylvana M.L., van Dieren, Susan, Koelemay, M. J.W., Balm, Ron, Balm, R., Elshof, J. W., Elsman, B. H.P., Hamming, J. F., Kropman, R. H.J., Poyck, P. P., Schurink, G. W.H., de Smet, A. A.E.A., van Sterkenburg, S. M., Ünlü, C., Vriens, P. W.H.E., de Vries, J. P.P.M., Wever, J. J., Wisselink, W., Zeebregts, C. J., Robotics and image-guided minimally-invasive surgery (ROBOTICS), Man, Biomaterials and Microbes (MBM), Surgery, ACS - Microcirculation, ACS - Atherosclerosis & ischemic syndromes, Epidemiology and Data Science, ACS - Diabetes & metabolism, ACS - Heart failure & arrhythmias, APH - Health Behaviors & Chronic Diseases, Graduate School, Amsterdam Gastroenterology Endocrinology Metabolism, APH - Methodology, Cell biology, Erasmus School of Law, Neurology, and Child and Adolescent Psychiatry / Psychology
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Endoleak ,Angiography ,Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10] ,Blood Vessel Prosthesis Implantation ,Treatment Outcome ,Risk Factors ,Endovascular procedures ,Vascular surgical procedures ,Humans ,Abdominal aortic aneurysm ,Surgery ,Prospective Studies ,Cardiology and Cardiovascular Medicine ,Tomography, X-Ray Computed ,Aortic Aneurysm, Abdominal ,Retrospective Studies - Abstract
Contains fulltext : 252341.pdf (Publisher’s version ) (Closed access) OBJECTIVE: Lifelong imaging surveillance is recommended following endovascular aneurysm repair (EVAR). This study aimed to examine the association between adherence to post-operative surveillance and survival and secondary interventions in patients with an initial post-operative computed tomography angiogram (CTA) without abnormalities. METHODS: All consecutive patients undergoing EVAR for intact abdominal aortic aneurysm (AAA) in 16 hospitals between 2007 and 2012 were identified retrospectively, with follow up until December 2018. Patients were included if the initial post-operative CTA showed no types I - III endoleak, kinking, infection, or limb occlusion. Discontinued follow up was defined as at least one 16 month period in which no imaging surveillance was performed. Primary outcomes were aneurysm related mortality and secondary interventions, and secondary outcome all cause mortality. Kaplan-Meier analysis was used to estimate survival, and Cox regression analyses to identify the association between independent variables and outcome. Sensitivity analyses were performed by varying the definition of continued yearly follow up. The study protocol was published (bmjopen-2019-033584). RESULTS: 1 596 patients (552 continued, 1 044 discontinued follow up) were included with a median (interquartile range) follow up of 89.1 months (52.6). Cumulative aneurysm related, overall, and intervention free survival was 99.4/94.8/96.1%, 98.5/72.9/85.9%, and 96.3/45.4/71.1% at 1, 5, and 10 years, respectively. American Society of Anesthesiologists (ASA) classification (ASA IV hazard ratio [HR] 3.810, 95% confidence interval [CI] 1.296 - 11.198), increase in AAA diameter (HR 3.299, 95% CI 1.408 - 7.729), and continued follow up (HR 3.611, 95% CI 1.780 - 7.323) were independently associated with aneurysm related mortality. The same variables and age (HR 1.063 per year, 95% CI 1.052 - 1.074) were significantly associated with all cause mortality. No difference in secondary interventions was observed between patients with continued vs. discontinued follow up (89/552; 16% vs. 136/1044; 13%; p = .091). Sensitivity analyses showed worse aneurysm related and overall survival in patients with continued follow up. CONCLUSION: Discontinued follow up is not associated with poor outcomes. Future prospective studies are indicated to determine in which patients imaging follow up can be safely reduced.
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- 2022
17. Treatment Outcome Trends for Non-Ruptured Abdominal Aortic Aneurysms: A Nationwide Prospective Cohort Study
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Alberga, Anna J., Karthaus, Eleonora G., Wilschut, Janneke A., de Bruin, Jorg L., Akkersdijk, George P., Geelkerken, Robert H., Hamming, Jaap F., Wever, Jan J., Verhagen, Hence J. M., van den Akker, P. J., Akkersdijk, G. P., Akkersdijk, W. L., van Andringa de Kempenaer, M. G., Arts, C. H. P., Avontuur, A. M., Bakker, O. J., Balm, R., Barendregt, W. B., Bekken, J. A., Bender, M. H. M., Bendermacher, B. L. W., van den Berg, M., Beuk, R. J., Blankensteijn, J. D., Bode, A. S., Bodegom, M. E., van der Bogt, K. E. A., Boll, A. P. M., Booster, M. H., Borger van der Burg, B. L. S., de Borst, G. J., Bos-van Rossum, W. T. G. J., Bosma, J., Botman, J. M. J., Bouwman, L. H., Brehm, V., de Bruijn, M. T., de Bruin, J. L., Brummel, P., van Brussel, J. P., Buijk, S. E., Buimer, M. G., Buscher, H. C. J. L., Cancrinus, E., Castenmiller, P. H., Cazander, G., Cuypers, P. H. W. M., Daemen, J. H. C., Dawson, I., Dierikx, J. E., Dijkstra, M. L., Diks, J., Dinkelman, M. K., Dirven, M., Dolmans, D. E. J. G. J., van Dortmont, L. M. C., Drouven, J. W., van der Eb, M. M., Eefting, D., van Eijck, G. J. W. M., Elshof, J. W. M., Elsman, B. H. P., van der Elst, A., van Engeland, M. I. A., van Eps, G. S., Faber, M. J., de Fijter, W. M., Fioole, B., Fritschy, W. M., Jin, P. H. P. F. K., Geelkerken, R. H., van Gent, W. B., Glade, G. J., Govaert, B., Groenendijk, R. P. R., de Groot, H. G. W., van den Haak, R. F. F., de Haan, E. F. A., Hajer, G. F., Hamming, J. F., van Hattum, E. S., Hazenberg, C. E. V. B., Hedeman Joosten, P. P. H. A., Helleman, J. N., van der Hem, L. G., Hendriks, J. M., van Herwaarden, J. A., Heyligers, J. M. M., Hinnen, J. W., Hissink, R. J., Ho, G. H., den Hoed, P. T., Hoedt, M. T. C., van Hoek, F., Hoencamp, R., Hoffmann, W. H., Hoksbergen, A. W. J., Hollander, E. J. F., Huisman, L. C., Hulsebos, R. G., Huntjens, K. M. B., Idu, M. M., Jacobs, M. J. H. M., van der Jagt, M. F. P., Jansbeken, J. R. H., Janssen, R. J. L., Jiang, H. H. L., de Jong, S. C., Jongbloed-Winkel, T. A., Jongkind, V., Kapma, M. R., Keller, B. P. J. A., Jahrome, A. K., Kievit, J. K., Klemm, P. L., Klinkert, P., Koedam, N. A., Koelemaij, M. J. W., Kolkert, J. L. P., Koning, G. G., Koning, O. H. J., Konings, R., Krasznai, A. G., Kropman, R. H. J., Kruse, R. R., van der Laan, L., van der Laan, M. J., van Laanen, J. H. H., van Lammeren, G. W., Lamprou, D. A. A., Lardenoije, J. H. P., Lauret, G. J., Leenders, B. J. M., Legemate, D. A., Leijdekkers, V. J., Lemson, M. S., Lensvelt, M. M. A., Lijkwan, M. A., van der Linden, F. T. H. P. M., Lung, P. F. Liqui, Loos, M. J. A., Loubert, M. C., van de Luijtgaarden, K. M., Mahmoud, D. E. A. K., Manshanden, C. G., Mattens, E. C. J. L., Meerwaldt, R., Mees, B. M. E., Menting, T. P., Metz, R., de Mol van Otterloo, J. C. A., Molegraaf, M. J., Montauban van Swijndregt, Y. C. A., Morak, M. J. M., van de Mortel, R. H. W., Mulder, W., Nagesser, S. K., Naves, C. C. L. M., Nederhoed, J. H., Nevenzel, A. M., de Nie, A. J., Nieuwenhuis, D. H., van Nieuwenhuizen, R. C., Nieuwenhuizen, J., Nio, D., Oomen, A. P. A., Oranen, B. I., Oskam, J., Palamba, H. W., Peppelenbosch, A. G., van Petersen, A. S., Petri, B. J., Pierie, M. E. N., Ploeg, A. J., Pol, R. A., Ponfoort, E. D., Poyck, P. P. C., Prent, A., Raa, S. ten, Raymakers, J. T. F. J., Reichmann, B. L., Reijnen, M. M. P. J., de Ridder, J. A. M., Rijbroek, A., van Rijn, M. J. E., de Roo, R. A., Rouwet, E. V., Saleem, B. R., van Sambeek, M. R. H. M., Samyn, M. G., van ’t Sant, H. P., van Schaik, J., van Schaik, P. M., Scharn, D. M., Scheltinga, M. R. M., Schepers, A., Schlejen, P. M., Schlösser, F. J. V., Schol, F. P. G., Scholtes, V. P. W., Schouten, O., Schreve, M. A., Schurink, G. W. H., Sikkink, C. J. J. M., Slaa, A. te, Smeets, H. J., Smeets, L., Smeets, R. R., de Smet, A. A. E. A., Smit, P. C., Smits, T. M., Snoeijs, M. G. J., Sondakh, A. O., Speijers, M. J., van der Steenhoven, T. J., van Sterkenburg, S. M. M., Stigter, D. A. A., Stokmans, R. A., Strating, R. P., Stultiëns, G. N. M., Sybrandy, J. E. M., Teijink, J. A. W., Telgenkamp, B. J., Testroote, M. J. G., Tha-in, T., The, R. M., Thijsse, W. J., Thomassen, I., Tielliu, I. F. J., van Tongeren, R. B. M., Toorop, R. J., Tournoij, E., Truijers, M., Türkcan, K., Tutein Nolthenius, R. P., Ünlü, C., Vaes, R. H. D., Vahl, A. C., Veen, E. J., Veger, H. T. C., Veldman, M. G., Verhagen, H. J. M., Verhoeven, B. A. N., Vermeulen, C. F. W., Vermeulen, E. G. J., Vierhout, B. P., van der Vijver-Coppen, R. J., Visser, M. J. T., van der Vliet, J. A., van Vlijmen - van Keulen, C. J., van der Vorst, J. R., Vos, A. W. F., Vos, C. G., Vos, G. A., de Vos, B., Voûte, M. T., Vriens, B. H. R., Vriens, P. W. H. E., de Vries, D. K., de Vries, J. P. P. M., de Vries, M., de Vries, A. C., van der Waal, C., Waasdorp, E. J., Wallis de Vries, B. M., van Walraven, L. A., van Wanroi, J. L., Warlé, M. C., van Weel, V., van Well, A. M. E., Welten, G. M. J. M., Wever, J. J., Wiersema, A. M., Wikkeling, O. R. M., Willaert, W. I. M., Wille, J., Willems, M. C. M., Willigendael, E. M., Wilschut, E. D., Wisselink, W., Witte, M. E., Wittens, C. H. A., Wong, C. Y., Yazar, O., Yeung, K. K., Zeebregts, C. J. A. M., van Zeeland, M. L. P., ACS - Microcirculation, Anesthesiology, Physiology, ACS - Pulmonary hypertension & thrombosis, Surgery, ACS - Atherosclerosis & ischemic syndromes, VU University medical center, ACS - Diabetes & metabolism, TechMed Centre, Multi-Modality Medical Imaging, Medical Biochemistry, and AGEM - Amsterdam Gastroenterology Endocrinology Metabolism
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Male ,Time Factors ,Operative procedure ,Vascular damage Radboud Institute for Health Sciences [Radboudumc 16] ,Risk Assessment ,Blood Vessel Prosthesis Implantation ,Postoperative Complications ,Risk Factors ,Humans ,Hospital Mortality ,Prospective Studies ,Registries ,Treatment outcome ,Aged ,Netherlands ,Retrospective Studies ,Aged, 80 and over ,Endovascular Procedures ,Quality of care ,Middle Aged ,Endovascular procedure ,Abdominal aortic aneurysm ,Surgery ,Female ,Trends ,Cardiology and Cardiovascular Medicine ,Aortic Aneurysm, Abdominal - Abstract
Contains fulltext : 251573.pdf (Publisher’s version ) (Open Access) OBJECTIVE: The Dutch Surgical Aneurysm Audit (DSAA) initiative was established in 2013 to monitor and improve nationwide outcomes of aortic aneurysm surgery. The objective of this study was to examine whether outcomes of surgery for intact abdominal aortic aneurysms (iAAA) have improved over time. METHODS: Patients who underwent primary repair of an iAAA by standard endovascular (EVAR) or open surgical repair (OSR) between 2014 and 2019 were selected from the DSAA for inclusion. The primary outcome was peri-operative mortality trend per year, stratified by OSR and EVAR. Secondary outcomes were trends per year in major complications, textbook outcome (TbO), and characteristics of treated patients. The trends per year were evaluated and reported in odds ratios per year. RESULTS: In this study, 11 624 patients (74.8%) underwent EVAR and 3 908 patients (25.2%) underwent OSR. For EVAR, after adjustment for confounding factors, there was no improvement in peri-operative mortality (aOR [adjusted odds ratio] 1.06, 95% CI 0.94 - 1.20), while major complications decreased (2014: 10.1%, 2019: 7.0%; aOR 0.91, 95% CI 0.88 - 0.95) and the TbO rate increased (2014: 68.1%, 2019: 80.9%; aOR 1.13, 95% CI 1.10 - 1.16). For OSR, the peri-operative mortality decreased (2014: 6.1%, 2019: 4.6%; aOR 0.89, 95% CI 0.82 - 0.98), as well as major complications (2014: 28.6%, 2019: 23.3%; aOR 0.95, 95% CI 0.91 - 0.99). Furthermore, the proportion of TbO increased (2014: 49.1%, 2019: 58.3%; aOR 1.05, 95% CI 1.01 - 1.10). In both the EVAR and OSR group, the proportion of patients with cardiac comorbidity increased. CONCLUSION: Since the establishment of this nationwide quality improvement initiative (DSAA), all outcomes of iAAA repair following EVAR and OSR have improved, except for peri-operative mortality following EVAR which remained unchanged.
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- 2022
18. The Correlation Between Wall Shear Stress and Plaque Composition in Advanced Human Carotid Atherosclerosis
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Moerman, A. M. (author), Korteland, S. (author), Dilba, K. (author), van Gaalen, K. (author), Poot, D. H.J. (author), van Der Lugt, A. (author), Verhagen, H. J.M. (author), Wentzel, J. J. (author), van Der Steen, A. F.W. (author), Gijsen, F.J.H. (author), Van der Heiden, K. (author), Moerman, A. M. (author), Korteland, S. (author), Dilba, K. (author), van Gaalen, K. (author), Poot, D. H.J. (author), van Der Lugt, A. (author), Verhagen, H. J.M. (author), Wentzel, J. J. (author), van Der Steen, A. F.W. (author), Gijsen, F.J.H. (author), and Van der Heiden, K. (author)
- Abstract
The role of wall shear stress (WSS) in atherosclerotic plaque development is evident, but the relation between WSS and plaque composition in advanced atherosclerosis, potentially resulting in plaque destabilization, is a topic of discussion. Using our previously developed image registration pipeline, we investigated the relation between two WSS metrics, time-averaged WSS (TAWSS) and the oscillatory shear index (OSI), and the local histologically determined plaque composition in a set of advanced human carotid plaques. Our dataset of 11 carotid endarterectomy samples yielded 87 histological cross-sections, which yielded 511 radial bins for analysis. Both TAWSS and OSI values were subdivided into patient-specific low, mid, and high tertiles. This cross-sectional study shows that necrotic core (NC) size and macrophage area are significantly larger in areas exposed to high TAWSS or low OSI. Local TAWSS and OSI tertile values were generally inversely related, as described in the literature, but other combinations were also found. Investigating the relation between plaque vulnerability features and different combinations of TAWSS and OSI tertile values revealed a significantly larger cap thickness in areas exposed to both low TAWSS and low OSI. In conclusion, our study confirmed previous findings, correlating high TAWSS to larger macrophage areas and necrotic core sizes. In addition, our study demonstrated new relations, correlating low OSI to larger macrophage areas, and a combination of low TAWSS and low OSI to larger cap thickness., Medical Instruments & Bio-Inspired Technology
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- 2022
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19. Patient-Reported Outcomes of Yearly Imaging Surveillance in Patients Following Endovascular Aortic Aneurysm Repair
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Geraedts, A. C.M., Mulay, S., Terwee, C. B., Vahl, A. C., Verhagen, H. J.M., Ünlü, Ubbink, D. T., Koelemay, M. J.W., Balm, R., Geraedts, A. C.M., Mulay, S., Terwee, C. B., Vahl, A. C., Verhagen, H. J.M., Ünlü, Ubbink, D. T., Koelemay, M. J.W., and Balm, R.
- Abstract
Little is known about the impact of standardized imaging surveillance on anxiety levels and well-being of patients after endovascular aortic aneurysm repair (EVAR). We hypothesize that patient anxiety levels increase just before receiving the imaging results compared with standard anxiety levels. Methods: Prospective cohort study from November 2018 to May 2020 including post-EVAR patients visiting the outpatient clinics of 4 Dutch hospitals for imaging follow-up. The Patient-Reported Outcomes Measurement Information System (PROMIS) was used. Patients completed the PROMIS Anxiety v1.0 Short Form (SF) 4a, PROMIS-Global Health Scale v1.2, and PROMIS-Physical Function v1.2 SF8b at 2 time points: prior to the result of the imaging study (T1: pre-visit) and 6–8 months later (T2: reference measurement). Mean T-scores at T1 were compared to T2, and T2 to the general 65+ Dutch population. Results: Altogether 342 invited patients were eligible, 214 completed the first questionnaire, 189 returned 2 completed questionnaires and 128 patients did not participate. Out of 214 respondents, 195 were male (91.1%) and the mean (standard deviation) age was 75.2 (7.0) years. There were no significant differences between T1 and T2 in anxiety levels (0.48; 95% confidence interval[CI] -0.42–1.38), global mental health (0.27; 95% CI -0.79–0.84), global physical health (0.10; 95% CI -0.38–1.18) and physical function (0.53; 95% CI -0.26–1.32). Compared with the 65+ Dutch population, at T2 patients experienced more anxiety (3.8; 95% CI 2.96–5.54), had worse global physical health (-3.2; 95% CI -4.38 – -2.02) and physical function (-2.4; 95% CI -4.00 – -0.80). Global mental health was similar (-1.0; 95% CI -2.21 – 0.21). Conclusions: Post-EVAR patients do not experience more anxiety just before receiving surveillance imaging results than outside this period, but do suffer from more anxiety and worse physical outcomes than the 65+ Dutch population.
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- 2022
20. The Correlation Between Wall Shear Stress and Plaque Composition in Advanced Human Carotid Atherosclerosis
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Moerman, A. M., Korteland, S., Dilba, K., van Gaalen, K., Poot, D. H.J., van Der Lugt, A., Verhagen, H. J.M., Wentzel, J. J., van Der Steen, A. F.W., Gijsen, F. J.H., Van der Heiden, K., Moerman, A. M., Korteland, S., Dilba, K., van Gaalen, K., Poot, D. H.J., van Der Lugt, A., Verhagen, H. J.M., Wentzel, J. J., van Der Steen, A. F.W., Gijsen, F. J.H., and Van der Heiden, K.
- Abstract
The role of wall shear stress (WSS) in atherosclerotic plaque development is evident, but the relation between WSS and plaque composition in advanced atherosclerosis, potentially resulting in plaque destabilization, is a topic of discussion. Using our previously developed image registration pipeline, we investigated the relation between two WSS metrics, time-averaged WSS (TAWSS) and the oscillatory shear index (OSI), and the local histologically determined plaque composition in a set of advanced human carotid plaques. Our dataset of 11 carotid endarterectomy samples yielded 87 histological cross-sections, which yielded 511 radial bins for analysis. Both TAWSS and OSI values were subdivided into patient-specific low, mid, and high tertiles. This cross-sectional study shows that necrotic core (NC) size and macrophage area are significantly larger in areas exposed to high TAWSS or low OSI. Local TAWSS and OSI tertile values were generally inversely related, as described in the literature, but other combinations were also found. Investigating the relation between plaque vulnerability features and different combinations of TAWSS and OSI tertile values revealed a significantly larger cap thickness in areas exposed to both low TAWSS and low OSI. In conclusion, our study confirmed previous findings, correlating high TAWSS to larger macrophage areas and necrotic core sizes. In addition, our study demonstrated new relations, correlating low OSI to larger macrophage areas, and a combination of low TAWSS and low OSI to larger cap thickness.
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- 2022
21. Biomarkers in epidemiological and toxicological nutrition research
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van Poppel, G., Verhagen, H., Heinzow, B., and Tennant, David R., editor
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- 1997
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22. Dietary chemoprevention in toxicological perspective
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Verhagen, H., Rompelberg, C. J. M., Strube, M., van Poppel, G., van Bladeren, P. J., and Tennant, David R., editor
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- 1997
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23. The Correlation Between Wall Shear Stress and Plaque Composition in Advanced Human Carotid Atherosclerosis
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Moerman, A. M., primary, Korteland, S., additional, Dilba, K., additional, van Gaalen, K., additional, Poot, D. H. J., additional, van Der Lugt, A., additional, Verhagen, H. J. M., additional, Wentzel, J. J., additional, van Der Steen, A. F. W., additional, Gijsen, F. J. H., additional, and Van der Heiden, K., additional
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- 2022
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24. Nuclear Characterisation of the Hfr Petten Bnct Facility
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Watkins, P., Harker, Y., Amaro, C., Voorbraak, W., Stecher-Rasmussen, F., Verhagen, H., Perks, C., Delafield, H., Constantine, G., Moss, R. L., Soloway, Albert H., editor, Barth, Rolf F., editor, and Carpenter, David E., editor
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- 1993
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25. Endovascular Salvage of a False Aneurysm of the Posterior Tibial Artery Caused by a Stab From a Stingray
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van Helden, E. J., Eefting, D., Florie, J., Verhagen, H. J. M., and Moelker, A.
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- 2015
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26. Delphi Study to Reach International Consensus Among Vascular Surgeons on Major Arterial Vascular Surgical Complications
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de Mik, S. M. L., Stubenrouch, F. E., Legemate, D. A., Balm, R., Ubbink, D. T., Becquemin, J. P., Blankensteijn, J. D., de Borst, G. J., Capoccia, L., Clair, D. G., Cronenwett, J. L., Davies, A. H., Elsman, B. H. P., Farber, M. A., Forbes, T. L., Goverde, P. C. J. M., van Herzeele, I., Hinchliffe, R. J., Jacobs, D. L., Jongkind, V., Liapis, C. D., Lönn, L., Montero-Baker, M., Moore, W. S., Naylor, A. R., Overbeck, K., Resch, T. A., Ronchey, S., Sakalihasan, N., Sarac, T. P., Setacci, C., Sillesen, H., Veith, F. J., Verhagen, H. J., Verzini, F., Wiersema, A. M., Department of Strategic Management and Entrepreneurship, Immunology, Surgery, ACS - Microcirculation, ACS - Diabetes & metabolism, ACS - Atherosclerosis & ischemic syndromes, Graduate School, APH - Personalized Medicine, and APH - Quality of Care
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Postoperative Complications/epidemiology ,Carotid Artery Diseases ,Male ,medicine.medical_specialty ,Consensus ,Delphi Technique ,Peripheral Arterial Disease/surgery ,SOCIETY ,Aged ,Aortic Aneurysm, Abdominal ,Female ,Humans ,Middle Aged ,Peripheral Arterial Disease ,Postoperative Complications ,Vascular Surgical Procedures ,03 medical and health sciences ,0302 clinical medicine ,Informed consent ,Carotid artery disease ,Medicine and Health Sciences ,medicine ,Abdominal ,Aortic Aneurysm, Abdominal/surgery ,cardiovascular diseases ,Carotid Artery Diseases/surgery ,Stroke ,business.industry ,General surgery ,Vascular surgery ,medicine.disease ,Abdominal aortic aneurysm ,Aortic Aneurysm ,Cardiac surgery ,Cardiothoracic surgery ,030220 oncology & carcinogenesis ,Vascular Surgical Procedures/adverse effects ,REPORTING STANDARDS ,030211 gastroenterology & hepatology ,Surgery ,business ,Abdominal surgery - Abstract
BACKGROUND: The complications discussed with patients by surgeons prior to surgery vary, because no consensus on major complications exists. Such consensus may improve informed consent and shared decision-making. This study aimed to achieve consensus among vascular surgeons on which complications are considered 'major' and which 'minor,' following surgery for abdominal aortic aneurysm (AAA), carotid artery disease (CAD) and peripheral artery disease (PAD).METHODS: Complications following vascular surgery were extracted from Cochrane reviews, national guidelines, and reporting standards. Vascular surgeons from Europe and North America rated complications as major or minor on five-point Likert scales via an electronic Delphi method. Consensus was reached if ≥ 80% of participants scored 1 or 2 (minor) or 4 or 5 (major).RESULTS: Participants reached consensus on 9-12 major and 6-10 minor complications per disease. Myocardial infarction, stroke, renal failure and allergic reactions were considered to be major complications of all three diseases. All other major complications were treatment specific or dependent on disease severity, e.g., spinal cord ischemia, rupture following AAA repair, stroke for CAD or deep wound infection for PAD.CONCLUSION: Vascular surgeons reached international consensus on major and minor complications following AAA, CAD and PAD treatment. This consensus may be helpful in harmonizing the information patients receive and improving standardization of the informed consent procedure. Since major complications differed between diseases, consensus on disease-specific complications to be discussed with patients is necessary.
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- 2019
27. Analysis of Outcomes After Endovascular Abdominal Aortic Aneurysm Repair in Patients With Abnormal Findings on the First Postoperative Computed Tomography Angiography
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Geraedts, Anna C. M., primary, Mulay, Sana, additional, van Dieren, Susan, additional, Koelemay, Mark J. W., additional, Balm, Ron, additional, Balm, R., additional, Elshof, J. W., additional, Elsman, B. H. P., additional, Hamming, J. F., additional, Koelemay, M. J. W., additional, Kropman, R. H. J., additional, Poyck, P. P., additional, Schurink, G. W. H., additional, de Smet, A. A. E. A, additional, van Sterkenburg, S. M., additional, Ünlü, C., additional, Vahl, A. C., additional, Verhagen, H. J. M., additional, Vriens, P. W. H. E., additional, de Vries, J. P. P. M., additional, Wever, J. J., additional, Wisselink, W., additional, and Zeebregts, C. J., additional
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- 2021
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28. SPECT/CT imaging of inflammation and calcification in human carotid atherosclerosis to identify the plaque at risk of rupture
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Van der Heiden, K., primary, Barrett, H. E., additional, Meester, E. J., additional, van Gaalen, K., additional, Krenning, B. J., additional, Beekman, F. J., additional, de Blois, E., additional, de Swart, J., additional, Verhagen, H. J. M., additional, van der Lugt, A., additional, Norenberg, J. P., additional, de Jong, M., additional, Bernsen, M. R., additional, and Gijsen, F. J. H., additional
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- 2021
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29. Human health risk–benefit assessment of fish and other seafood: a scoping review
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Thomsen, S.T. Assunção, R. Afonso, C. Boué, G. Cardoso, C. Cubadda, F. Garre, A. Kruisselbrink, J.W. Mantovani, A. Pitter, J.G. Poulsen, M. Verhagen, H. Ververis, E. Voet, H.V.D. Watzl, B. Pires, S.M.
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integumentary system ,food and beverages - Abstract
Fish and other seafood are important sources of nutrients, but they are also sources of chemical contaminants that may cause adverse health effects. This article aimed to identify existing risk–benefit assessments (RBA) of fish, shellfish, and other seafood, compare methodologies, discuss differences and commonalities in findings, and identify limitations and ways forward for future studies. We conducted a scoping review of the scientific literature of studies in all languages published from 2000 through April 2019. We identified 106 RBA of fish and other seafood across Europe, Asia, North America, Africa, and at the global level. Studies were heterogeneous in terms of types of fish and other seafood considered, beneficial and adverse compounds assessed, and overall methodology. Collected data showed that a diet consisting of a variety of lean and fatty fish and other seafood is recommended for the overall population and that women of childbearing age and children should limit the consumption of fish and other seafood types that have a high likelihood of contamination. Our review emphasizes the need for evidence-based, up-to-date, and harmonized approaches in RBA in general. © 2021 Taylor & Francis Group, LLC.
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- 2021
30. SPECT/CT imaging of inflammation and calcification in human carotid atherosclerosis to identify the plaque at risk of rupture
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Van der Heiden, K. (author), Barrett, H. E. (author), van Gaalen, K.C. (author), Krenning, B. J. (author), Beekman, F.J. (author), Verhagen, H. J.M. (author), Norenberg, J. P. (author), de Jong, M. (author), Gijsen, F.J.H. (author), Van der Heiden, K. (author), Barrett, H. E. (author), van Gaalen, K.C. (author), Krenning, B. J. (author), Beekman, F.J. (author), Verhagen, H. J.M. (author), Norenberg, J. P. (author), de Jong, M. (author), and Gijsen, F.J.H. (author)
- Abstract
Background: Calcification and inflammation are atherosclerotic plaque compositional biomarkers that have both been linked to stroke risk. The aim of this study was to evaluate their co-existing prevalence in human carotid plaques with respect to plaque phenotype to determine the value of hybrid imaging for the detection of these biomarkers. Methods: Human carotid plaque segments, obtained from endarterectomy, were incubated in [111In]In-DOTA-butylamino-NorBIRT ([111In]In-Danbirt), targeting Leukocyte Function-associated Antigen-1 (LFA-1) on leukocytes. By performing SPECT/CT, both inflammation from DANBIRT uptake and calcification from CT imaging were assessed. Plaque phenotype was classified using histology. Results: On a total plaque level, comparable levels of calcification volume existed with different degrees of inflammation and vice versa. On a segment level, an inverse relationship between calcification volume and inflammation was evident in highly calcified segments, which classify as fibrocalcific, stable plaque segments. In contrast, segments with little or no calcification presented with a moderate to high degree of inflammation, often coinciding with the more dangerous fibrous cap atheroma phenotype. Conclusion: Calcification imaging alone can only accurately identify highly calcified, stable, fibrocalcific plaques. To identify high-risk plaques, with little or no calcification, hybrid imaging of calcification and inflammation could provide diagnostic benefit., RST/Biomedical Imaging
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- 2021
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31. Analysis of Outcomes After Endovascular Abdominal Aortic Aneurysm Repair in Patients With Abnormal Findings on the First Postoperative Computed Tomography Angiography
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Geraedts, Anna C.M., Mulay, Sana, van Dieren, Susan, Koelemay, M. J.W., Balm, R., Elshof, J. W., Elsman, B. H.P., Hamming, J. F., Kropman, R. H.J., Poyck, P. P., Schurink, G. W.H., de Smet, A. A.E.A., van Sterkenburg, S. M., Ünlü, C., Vahl, A. C., Verhagen, H. J.M., Vriens, P. W.H.E., de Vries, J. P.P.M., Wever, J. J., Wisselink, W., Zeebregts, C. J., Geraedts, Anna C.M., Mulay, Sana, van Dieren, Susan, Koelemay, M. J.W., Balm, R., Elshof, J. W., Elsman, B. H.P., Hamming, J. F., Kropman, R. H.J., Poyck, P. P., Schurink, G. W.H., de Smet, A. A.E.A., van Sterkenburg, S. M., Ünlü, C., Vahl, A. C., Verhagen, H. J.M., Vriens, P. W.H.E., de Vries, J. P.P.M., Wever, J. J., Wisselink, W., and Zeebregts, C. J.
- Abstract
Purpose: Lifelong follow-up after endovascular abdominal aortic aneurysm repair (EVAR) is recommended due to a continued risk of complications, especially if the first postoperative imaging shows abnormal findings. We studied the long-term outcomes in patients with abnormalities on the first postoperative computed tomography angiography (CTA) following EVAR. Materials and Methods: This is a retrospective study of all consecutive patients who underwent elective EVAR for nonruptured abdominal aortic aneurysm (AAA) between January 2007 and January 2012 in 16 Dutch hospitals with follow-up until December 2018. Patients were included if the first postoperative CTA showed one of the following abnormal findings: endoleak type I–IV, endograft kinking, infection, or limb occlusion. AAA diameter, complications, and secondary interventions during follow-up were registered. Primary endpoint was overall survival, and other endpoints were secondary interventions and intervention-free survival. Kaplan-Meier analyses were used to estimate overall and intervention-free survival. Cox regression analyses were used to identify the association of independent determinants with survival and secondary interventions. Results: A total of 502 patients had abnormal findings on the first postoperative CTA after EVAR and had a median follow-up (interquartile range IQR) of 83.0 months (59.0). The estimated overall survival rate at 1, 5, and 10 years was 84.7%, 51.0%, and 30.8%, respectively. Age [hazard ratio (HR) 1.06, 95% confidence interval (CI) 1.05 to 1.10] and American Society of Anesthesiologists (ASA) classification (ASA IV HR 3.20, 95% CI 1.99 to 5.15) were significantly associated with all-cause mortality. Overall, 167 of the 502 patients (33.3%) underwent 238 secondary interventions in total. Fifty-eight patients (12%) underwent an intervention based on a finding on the first postoperative CTA. Overall survival was 38.4% for patients with secondary interventions and 44.5% for patien
- Published
- 2021
32. SPECT/CT imaging of inflammation and calcification in human carotid atherosclerosis to identify the plaque at risk of rupture
- Author
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Van der Heiden, K., Barrett, H. E., Meester, E. J., van Gaalen, K., Krenning, B. J., Beekman, F. J., de Blois, E., de Swart, J., Verhagen, H. J.M., van der Lugt, A., Norenberg, J. P., de Jong, M., Bernsen, M. R., Gijsen, F. J.H., Van der Heiden, K., Barrett, H. E., Meester, E. J., van Gaalen, K., Krenning, B. J., Beekman, F. J., de Blois, E., de Swart, J., Verhagen, H. J.M., van der Lugt, A., Norenberg, J. P., de Jong, M., Bernsen, M. R., and Gijsen, F. J.H.
- Abstract
Background: Calcification and inflammation are atherosclerotic plaque compositional biomarkers that have both been linked to stroke risk. The aim of this study was to evaluate their co-existing prevalence in human carotid plaques with respect to plaque phenotype to determine the value of hybrid imaging for the detection of these biomarkers. Methods: Human carotid plaque segments, obtained from endarterectomy, were incubated in [111In]In-DOTA-butylamino-NorBIRT ([111In]In-Danbirt), targeting Leukocyte Function-associated Antigen-1 (LFA-1) on leukocytes. By performing SPECT/CT, both inflammation from DANBIRT uptake and calcification from CT imaging were assessed. Plaque phenotype was classified using histology. Results: On a total plaque level, comparable levels of calcification volume existed with different degrees of inflammation and vice versa. On a segment level, an inverse relationship between calcification volume and inflammation was evident in highly calcified segments, which classify as fibrocalcific, stable plaque segments. In contrast, segments with little or no calcification presented with a moderate to high degree of inflammation, often coinciding with the more dangerous fibrous cap atheroma phenotype. Conclusion: Calcification imaging alone can only accurately identify highly calcified, stable, fibrocalcific plaques. To identify high-risk plaques, with little or no calcification, hybrid imaging of calcification and inflammation could provide diagnostic benefit.
- Published
- 2021
33. Risk-benefit in food safety and nutrition – Outcome of the 2019 Parma Summer School
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Verhagen, H., Alonso-Andicoberry, C., Assuncao, R., Cavaliere, F., Eneroth, H., Hoekstra, J., Koulouris, S., Kouroumalis, A., Lorenzetti, S., Mantovani, A., Menozzi, D., Nauta, M., Poulsen, M., Rubert, J., Siani, A., Sirot, V., Spaggiari, G., Thomsen, S. T., Trevisan, Marco, Cozzini, P., Trevisan M. (ORCID:0000-0002-4002-9946), Verhagen, H., Alonso-Andicoberry, C., Assuncao, R., Cavaliere, F., Eneroth, H., Hoekstra, J., Koulouris, S., Kouroumalis, A., Lorenzetti, S., Mantovani, A., Menozzi, D., Nauta, M., Poulsen, M., Rubert, J., Siani, A., Sirot, V., Spaggiari, G., Thomsen, S. T., Trevisan, Marco, Cozzini, P., and Trevisan M. (ORCID:0000-0002-4002-9946)
- Abstract
Risk-benefit assessment is the comparison of the risk of a situation to its related benefits, i.e. a comparison of scenarios estimating the overall health impact. The risk–benefit analysis paradigm mirrors the classical risk analysis one: risk–benefit assessment goes hand-in-hand with risk–benefit management and risk–benefit communication. The various health effects associated with food consumption, together with the increasing demand for advice on healthy and safe diets, have led to the development of different research disciplines in food safety and nutrition. In this sense, there is a clear need for a holistic approach, including and comparing all of the relevant health risks and benefits. The risk–benefit assessment of foods is a valuable approach to estimate the overall impact of food on health. It aims to assess together the negative and positive health effects associated with food intake by integrating chemical and microbiological risk assessment with risk and benefit assessment in food safety and nutrition. The 2019 Parma Summer School on risk–benefit in food safety and nutrition had the objective was to provide an opportunity to learn from experts in the field of risk–benefit approach in food safety and nutrition, including theory, case studies, and communication of risk–benefit assessments plus identify challenges for the future. It was evident that whereas tools and approaches have been developed, more and more case studies have been performed which can form an inherent validation of the risk–benefit approach. Executed risk–benefit assessment case studies apply the steps and characteristics developed: a problem formulation (with at least 2 scenarios), a tiered approach until a decision can be made, one common currency to describe both beneficial and adverse effects (DALYs in most instances). It was concluded that risk–benefit assessment in food safety and nutrition is gaining more and more momentum, while also many challenges remain for the future. Risk-b
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- 2021
34. Short-term outcomes of open surgical abdominal aortic aneurysm repair from the Dutch Surgical Aneurysm Audit
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Geraedts, A.C.M., Alberga, A. J., Koelemay, M. J.W., Verhagen, H. J.M., Vahl, A. C., Balm, R., Geraedts, A.C.M., Alberga, A. J., Koelemay, M. J.W., Verhagen, H. J.M., Vahl, A. C., and Balm, R.
- Abstract
BACKGROUND: The sharp decrease in open surgical repair (OSR) for abdominal aortic aneurysm (AAA) has raised concerns about contemporary postoperative outcomes. The study was designed to analyse the impact of complications on clinical outcomes within 30 days following OSR. METHODS: Patients who underwent OSR for intact AAA registered prospectively between 2016 and 2019 in the Dutch Surgical Aneurysm Audit were included. Complications and outcomes (death, secondary interventions, prolonged hospitalization) were evaluated. The adjusted relative risk (aRr) and 95 per cent confidence intervals were computed using Poisson regression. Subsequently, the population-attributable fraction (PAF) was calculated. The PAF reflects the expected percentage reduction of an outcome if a complication were to be completely prevented. RESULTS: A total of 1657 patients were analysed. Bowel ischaemia and renal complications had the largest impact on death (aRr 12·44 (95 per cent c.i. 7·95 to 19·84) at PAF 20 (95 per cent c.i. 8·4 to 31·5) per cent and aRr 5·07 (95 per cent c.i. 3·18 to 8.07) at PAF 14 (95 per cent c.i. 0·7 to 27·0) per cent, respectively). Arterial occlusion had the greatest impact on secondary interventions (aRr 11·28 (95 per cent c.i. 8·90 to 14·30) at PAF 21 (95 per cent c.i. 14·7 to 28·1) per cent), and pneumonia (aRr 2·52 (95 per cent c.i. 2·04 to 3·10) at PAF 13 (95 per cent c.i. 8·3 to 17·8) per cent) on prolonged hospitalization. Small effects were observed on outcomes for other complications. CONCLUSION: The greatest clinical impact following OSR can be made by focusing on measures to reduce the occurrence of bowel ischaemia, arterial occlusion and pneumonia.
- Published
- 2021
35. Consuming a diet complying with front-of-pack label criteria may reduce cholesterol levels: a modeling study
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Vyth, E L, Hendriksen, M A H, Roodenburg, A J C, Steenhuis, I H M, van Raaij, J M A, Verhagen, H, Brug, J, and Seidell, J C
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- 2012
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36. Early sac shrinkage predicts a low risk of late complications after endovascular aortic aneurysm repair
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Bastos Gonçalves, F., Baderkhan, H., Verhagen, H. J. M., Wanhainen, A., Björck, M., Stolker, R. J., Hoeks, S. E., and Mani, K.
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- 2014
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37. Type II endoleak after endovascular aneurysm repair (Br J Surg 2013; 100: 1262–1270
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Gonçalves, Bastos F., Oliveira, N. F., and Verhagen, H. J. M.
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- 2014
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38. Dietary intake of the water-soluble vitamins B1, B2, B6, B12 and C in 10 countries in the European Prospective Investigation into Cancer and Nutrition
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Olsen, A., Halkjaer, J., van Gils, C.H., Buijsse, B., Verhagen, H., Jenab, M., Boutron-Ruault, M.C., Ericson, U., Ocke, M.C., Peeters, P.H.M., Touvier, M., Niravong, M., Waaseth, M., Skeie, G., Khaw, K.T., Travis, R., Ferrari, P., Sanchez, M.J., Agudo, A., Overvad, K., Linseisen, J., Weikert, C., Sacerdote, C., Evangelista, A., Zylis, D., Tsiotas, K., Manjer, J., van Guelpen, B., Riboli, E., Slimani, N., and Bingham, S.
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Oncology, Experimental -- Health aspects ,Vitamin C -- Health aspects -- Research ,Vitamin B -- Health aspects -- Research ,Cancer -- Research ,Vitamin B in human nutrition -- Research -- Health aspects ,Vitamin B complex -- Health aspects -- Research ,Recommended daily allowances -- Research -- Health aspects ,Food/cooking/nutrition ,Health - Abstract
Objectives: To describe the intake of vitamins thiamine (B1), riboflavin (B2), B6 (pyridoxine), B12 (cobalamine) and C (ascorbic acid) and their food sources among 27 centres in 10 countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Methods: Between 1995 and 2000, 36 034 persons aged between 35 and 74 years were administered a standardized 24-h dietary recall using a computerized interview software programme (EPIC-SOFT). Intakes of the four B vitamins and vitamin C were estimated using the standardized EPIC Nutrient Database (ENDB). Mean intakes were adjusted for age and weighted by season and day of recall. Results: Intake of B vitamins did not vary considerably between centres, except in the UK health-conscious cohort, in which substantially higher intakes of thiamine and lower intakes of vitamin B12 were reported compared with other centres. Overall, meat was the most important contributor to the B vitamins in all centres except in the UK health-conscious group. Vitamin C showed a clear geographical gradient, with higher intakes in the southern centres as compared with the northern ones; this was more pronounced in men than in women. Vegetables and fruits were major contributors to vitamin C in all centres, but juices and potatoes were also important sources in the northern centres. Conclusions: This study showed no major differences across centres in the mean intakes of B vitamins (thiamine, riboflavin, B6, B12), whereas a tendency towards a north-south gradient was observed for vitamin C. doi: 10.1038/ejcn.2009.78 Keywords: water-soluble vitamins; 24-h dietary recall; standardization; ENDB; EPIC; Europe, Introduction The B vitamins, together with vitamin C, constitute the water-soluble group of vitamins. Classic syndromes caused by a deficiency of water-soluble vitamins, such as scurvy (vitamin C) and beriberi [...]
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- 2009
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39. Biomonitoring as an Underused Exposure Assessment Tool in Occupational Safety and Health Context-Challenges and Way Forward
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Viegas, S., Zare Jeddi, M., Hopf, N.B., Bessems, J., Palmen, N., S Galea, K., Jones, K., Kujath, P., Duca, R.C., Verhagen, H., Santonen, T., and Pasanen-Kase, R.
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Biological Monitoring ,Environmental Exposure/analysis ,Environmental Monitoring ,Humans ,Occupational Exposure/analysis ,Occupational Health ,Risk Assessment ,Risk Management ,biological guidance value ,biological limit value ,biological monitoring ,exposure assessment ,occupational health ,risk assessment - Abstract
Recent advances in analytical chemistry have allowed a greater possibility of using quantitative approaches for measuring human exposure to chemicals. One of these approaches is biomonitoring (BM), which provides unequivocal evidence that both exposure and uptake of a chemical have taken place. BM has been a longstanding practice in occupational health for several reasons. BM integrates exposure from all routes. It can help identify unintentional and unexpected exposures and assess the effectiveness of existing risk-management measures. BM also provides relevant information to support policy development by delivering better evidence of workers' exposure to chemical substances, even within the framework of the present regulations. Thus, BM can allow for both the evaluation of the impact of regulation and identification of further needs for new or improved regulation. However, despite all these well-recognized advantages, BM is currently an underused exposure assessment tool. This paper provides an overview of the key aspects to be considered when using BM in the context of occupational health interventions. Additionally, this paper describes the potential of BM as an exposure assessment tool, distinguishing the role of BM in exposure assessment and health surveillance and clarifies ethical and communication aspects to guarantee that general data protection regulations are followed. In addition, actions and research needs are identified (particularly with reference to the European situation), which aim to encourage the increased use of BM as an exposure assessment tool.
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- 2020
40. Alterações Morfológicas e Consequências Clínicas do Tratamento de Colos Proximais Largos Requerendo Endopróteses com 34-36mm de Diâmetro
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Oliveira-Pinto, J, Soares Ferreira, R, Oliveira, N, Bastos Gonçalves, F, Hoeks, S, Rijn, MJ, Raa, S, Mansilha, A, and Verhagen, H
- Subjects
Aneurisma da Aorta Abdominal ,Tratamento ,HSM CIR VASC ,Colo - Abstract
Introdução: O tratamento endovascular representa o método de eleição para o tratamento de Aneurismas da Aorta Abdominal (AAA). Existem endopróteses disponíveis com diâmetros do colo proximal até 36mm, que permitem o tratamento de colos proximais até 32 mm. Contudo, a existência de colos largos representa um conhecido preditor de complicações. O objetivo deste estudo é avaliar os resultados a médio-prazo de doentes que requereram endopróteses de 34-36mm. Métodos: Foi realizada uma análise retrospetiva de uma base de dados prospetiva, incluindo todos os pacientes submetidos a EVAR por AAA degenerativo numa instituição terciária na Holanda. Todas as medições foram realizadas em reconstruções center-lumen line em software dedicado. Os pacientes foram classificados como “diâmetro largo” (LD), se a endoprótese implantada tivesse diâmetro superior a 32 mm.. Os restantes pacientes foram classificados como diâmetro normal (ND). O endpoint primário foi complicações relacionadas com o colo (combinação de endoleak tipo IA, migração>5mm ou qualquer intervenção no colo proximal). Alterações morfológicas no colo e sobrevida foram também analisadas. Diferenças entre grupos foram ajustadas por regressão multivariável. Resultados: O estudo incluiu 502 pacientes (90 no grupo LD e 412 no grupo ND). O follow-up mediano foi de 3.5 anos IQR (1.5–6.2) e 4.5 anos IQR (2.1–7.3) para os grupos LD e ND, respetivamente, P=.008. Relativamente às características basais, os doentes no grupo LD, apresentavam maior incidência de hipertensão arterial (83% vs 69.7%, P=.012) e tabagismo (86% vs 84.1%, P=.018). Além de colos mais largos (colo Proximal Ø > 28 mm: 75% vs 3.3%, P45º: 21% vs 9%, P=.002), cónicos (39.8% vs 20.3%, P25%: 42% vs 32.3%, P5 mm ocorreu similarmente entre grupos (7.8% vs 5.1%, P=.32). Reintervenções relacionadas com colo o foram também mais frequentes no grupo LD (13.3% vs 8.7%, P=.027). info:eu-repo/semantics/publishedVersion
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- 2020
41. Selecting the Right Game Concept for Social Simulation of Real-World Systems
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Verhagen, H., Borit, M., Bravo, G., Wijermans, N., Bekius, F.A., Meijer, S., Verhagen, H., Borit, M., Bravo, G., Wijermans, N., Bekius, F.A., and Meijer, S.
- Abstract
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- Published
- 2020
42. Computational models that matter during a global pandemic outbreak: A call to action
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Squazzoni, F, Polhill, JG, Edmonds, B, Ahrweiler, P, Antosz, P, Scholz, G, Chappin, E, Borit, M, Verhagen, H, Giardini, F, Gilbert, N, Squazzoni, F, Polhill, JG, Edmonds, B, Ahrweiler, P, Antosz, P, Scholz, G, Chappin, E, Borit, M, Verhagen, H, Giardini, F, and Gilbert, N
- Abstract
The COVID-19 pandemic is causing a dramatic loss of lives worldwide, challenging the sustainability of our health care systems, threatening economic meltdown, and putting pressure on the mental health of individuals (due to social distancing and lock-down measures). The pandemic is also posing severe challenges to the scientific community, with scholars under pressure to respond to policymakers’ demands for advice despite the absence of adequate, trusted data. Understanding the pandemic requires fine-grained data representing specific local conditions and the social reactions of individuals. While experts have built simulation models to estimate disease trajectories that may be enough to guide decision-makers to formulate policy measures to limit the epidemic, they do not cover the full behavioural and social complexity of societies under pandemic crisis. Modelling that has such a large potential impact upon people’s lives is a great responsibility. This paper calls on the scientific community to improve the transparency, access, and rigour of their models. It also calls on stakeholders to improve the rapidity with which data from trusted sources are released to the community (in a fully responsible manner). Responding to the pandemic is a stress test of our collaborative capacity and the social/economic value of research.
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- 2020
43. Imaging of inflammatory cellular protagonists in human atherosclerosis: a dual-isotope SPECT approach
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Barrett, Hilary E. (author), Meester, Eric J. (author), van Gaalen, Kim (author), van der Heiden, Kim (author), Krenning, Boudewijn J. (author), Beekman, F.J. (author), Verhagen, H. J. (author), de Jong, M. (author), Gijsen, F.J.H. (author), Barrett, Hilary E. (author), Meester, Eric J. (author), van Gaalen, Kim (author), van der Heiden, Kim (author), Krenning, Boudewijn J. (author), Beekman, F.J. (author), Verhagen, H. J. (author), de Jong, M. (author), and Gijsen, F.J.H. (author)
- Abstract
Purpose: Atherosclerotic plaque development and progression signifies a complex inflammatory disease mediated by a multitude of proinflammatory leukocyte subsets. Using single photon emission computed tomography (SPECT) coupled with computed tomography (CT), this study tested a new dual-isotope acquisition protocol to assess each radiotracer’s capability to identify plaque phenotype and inflammation levels pertaining to leukocytes expressing leukocyte function-associated antigen-1 (LFA-1) and the leukocyte subset of proinflammatory macrophages expressing somatostatin receptor subtype-2 (SST2). Individual radiotracer uptake was quantified and the presence of corresponding immunohistological cell markers was assessed. Methods: Human symptomatic carotid plaque segments were obtained from endarterectomy. Segments were incubated in dual-isotope radiotracers [111In]In-DOTA-butylamino-NorBIRT ([111In]In-Danbirt) and [99mTc]Tc-[N0–1 4,Asp0,Tyr3]-octreotate ([99mTc]Tc-Demotate 2) before scanning with SPECT/CT. Plaque phenotype was classified as pathological intimal thickening, fibrous cap atheroma or fibrocalcific using histology sections based on distinct morphological characteristics. Plaque segments were subsequently immuno-stained with LFA-1 and SST2 and quantified in terms of positive area fraction and compared against the corresponding SPECT images. Results: Focal uptake of co-localising dual-radiotracers identified the heterogeneous distribution of inflamed regions in the plaques which co-localised with positive immuno-stained regions of LFA-1 and SST2. [111In]In-Danbirt and [99mTc]Tc-Demotate 2 uptake demonstrated a significant positive correlation (r = 0.651; p = 0.001). Fibrous cap atheroma plaque phenotype correlated with the highest [111In]In-Danbirt and [99mTc]Tc-Demotate 2 uptake compared with fi, RST/Biomedical Imaging
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- 2020
- Full Text
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44. New technologies for the good of whom? Whose values win?
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Kinnula, A. (Atte), Kinnula, M. (Marianne), Verhagen, H. (Harko), Kinnula, A. (Atte), Kinnula, M. (Marianne), and Verhagen, H. (Harko)
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- 2020
45. Imaging of inflammatory cellular protagonists in human atherosclerosis:a dual-isotope SPECT approach
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Barrett, Hilary E., Meester, Eric J., van Gaalen, Kim, van der Heiden, Kim, Krenning, Boudewijn J., Beekman, Freek J., de Blois, Erik, de Swart, Jan, Verhagen, H. J., Maina, Theodosia, Nock, Berthold A., Norenberg, Jeffrey P., de Jong, Marion, Gijsen, Frank J.H., Bernsen, Monique R., Barrett, Hilary E., Meester, Eric J., van Gaalen, Kim, van der Heiden, Kim, Krenning, Boudewijn J., Beekman, Freek J., de Blois, Erik, de Swart, Jan, Verhagen, H. J., Maina, Theodosia, Nock, Berthold A., Norenberg, Jeffrey P., de Jong, Marion, Gijsen, Frank J.H., and Bernsen, Monique R.
- Abstract
Purpose: Atherosclerotic plaque development and progression signifies a complex inflammatory disease mediated by a multitude of proinflammatory leukocyte subsets. Using single photon emission computed tomography (SPECT) coupled with computed tomography (CT), this study tested a new dual-isotope acquisition protocol to assess each radiotracer’s capability to identify plaque phenotype and inflammation levels pertaining to leukocytes expressing leukocyte function-associated antigen-1 (LFA-1) and the leukocyte subset of proinflammatory macrophages expressing somatostatin receptor subtype-2 (SST2). Individual radiotracer uptake was quantified and the presence of corresponding immunohistological cell markers was assessed. Methods: Human symptomatic carotid plaque segments were obtained from endarterectomy. Segments were incubated in dual-isotope radiotracers [111In]In-DOTA-butylamino-NorBIRT ([111In]In-Danbirt) and [99mTc]Tc-[N0–14,Asp0,Tyr3]-octreotate ([99mTc]Tc-Demotate 2) before scanning with SPECT/CT. Plaque phenotype was classified as pathological intimal thickening, fibrous cap atheroma or fibrocalcific using histology sections based on distinct morphological characteristics. Plaque segments were subsequently immuno-stained with LFA-1 and SST2 and quantified in terms of positive area fraction and compared against the corresponding SPECT images. Results: Focal uptake of co-localising dual-radiotracers identified the heterogeneous distribution of inflamed regions in the plaques which co-localised with positive immuno-stained regions of LFA-1 and SST2. [111In]In-Danbirt and [99mTc]Tc-Demotate 2 uptake demonstrated a significant positive correlation (r = 0.651; p = 0.001). Fibrous cap atheroma plaque phenotype correlated with the highest [111In]In-Danbirt and [99mTc]Tc-Demotate 2 uptake compared with fib
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- 2020
46. Kinetics of biomarkers: biological and technical validity of isoprostanes in plasma
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Coolen, S. A. J., van Buuren, B., Duchateau, G., Upritchard, J., and Verhagen, H.
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- 2005
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47. EFSA’s OpenFoodTox: An open source toxicological database on chemicals in food and feed and its future developments
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Dorne, J.L.C.M., primary, Richardson, J., additional, Livaniou, A., additional, Carnesecchi, E., additional, Ceriani, L., additional, Baldin, R., additional, Kovarich, S., additional, Pavan, M., additional, Saouter, E., additional, Biganzoli, F., additional, Pasinato, L., additional, Zare Jeddi, M., additional, Robinson, T.P., additional, Kass, G.E.N., additional, Liem, A.K.D., additional, Toropov, A.A., additional, Toropova, A.P., additional, Yang, C., additional, Tarkhov, A., additional, Georgiadis, N., additional, Di Nicola, M.R., additional, Mostrag, A., additional, Verhagen, H., additional, Roncaglioni, A., additional, Benfenati, E., additional, and Bassan, A., additional
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- 2021
- Full Text
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48. Information resources for professionals in the area of (functional) food, dietary supplements and medicines
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van Kranen, H. J., Toxopeus, I. B., Buurma, E., Vroom, F., Verhagen, H., and Rompelberg, C. J.M.
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- 2011
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49. Health benefits and costs of functional foods with phytosterols/-stanols in addition to statins in the prevention of cardiovascular disease
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Eussen, S. R.B.M., Feenstra, T. L., Toxopeus, I. B., Hoekstra, J., Verhagen, H., and Rompelberg, C. J.M.
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- 2011
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50. Integrated benefit–risk assessment of food and pharma
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Verhagen, H., Luteijn, J. M., White, B. C., Eussen, S. R.B.M., Rompelberg, C. J.M., Hoekstra, J., and Tijhuis, M.
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- 2011
- Full Text
- View/download PDF
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